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Tomas Mustelin

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Stephanie M Stanford; Heather A Arnett; Beatrix Bartok; David L Boyle; Amanda M Campbell; Gary S Firestein; William B Kiosses; Michael F Maestre; Tomas Mustelin; Nunzio Bottini
Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 Domain-Containing Phosphatase 2 as a Modulator of Invasion and Survival.
Torkel Vang; Marte K Viken; Johannes Landskron; Tomas Mustelin; Nikolaus Oberprieler; Robert C Rickert; Kjetil Tasken; Lutz Tautz; Knut Martin Torgersen; Benedicte A Lie
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Torkel Vang; Stefan Vasile; Shuangding Wu; Li Yang; Michel L Tremblay; Russell Dahl; Laurence Delacroix; Dana Francis; Johannes Landskron; Benedicte A Lie; Wallace H Liu; Tomas Mustelin; Lucia Musumeci; Rebecca Page; Souad Rahmouni; Robert C Rickert; Kjetil Tasken; Lutz Tautz
LYP inhibits T-cell activation when dissociated from CSK.

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2013: Stephanie M Stanford; Heather A Arnett; Beatrix Bartok; David L Boyle; Amanda M Campbell; Gary S Firestein; William B Kiosses; Michael F Maestre; Tomas Mustelin; Nunzio Bottini
Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 Domain-Containing Phosphatase 2 as a Modulator of Invasion and Survival.
Arthritis and rheumatism 2013;65(5):1171-80.
2013: Torkel Vang; Marte K Viken; Johannes Landskron; Tomas Mustelin; Nikolaus Oberprieler; Robert C Rickert; Kjetil Tasken; Lutz Tautz; Knut Martin Torgersen; Benedicte A Lie
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Human immunology 2013;74(5):574-85.
2012: Torkel Vang; Stefan Vasile; Shuangding Wu; Li Yang; Michel L Tremblay; Russell Dahl; Laurence Delacroix; Dana Francis; Johannes Landskron; Benedicte A Lie; Wallace H Liu; Tomas Mustelin; Lucia Musumeci; Rebecca Page; Souad Rahmouni; Robert C Rickert; Kjetil Tasken; Lutz Tautz
LYP inhibits T-cell activation when dissociated from CSK.
Nature chemical biology 2012;8(5):437-46.
2012: Eduard Sergienko; Shyama Sidique; Ying Su; Stefan Vasile; Jian Xu; Li Yang; Hongbin Yuan; Ekaterina V Bobkova; Brock T Brown; Xochella Chan; Thomas D Y Chung; Sharon Colayco; Nicholas D P Cosford; David A Critton; Russell Dahl; Wallace H Liu; Paul J Lombroso; Tomas Mustelin; Rebecca Page; Justin Rascon; Lutz Tautz
Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.
ACS chemical biology 2012;7(2):367-77.
2012: Jian Huang; Xin Liu; Tomas Mustelin; Ting Shi; Yanli Wang; Jie Yan; Cheng Chen; Guoqiang Chen; Jinke Cheng; Gen-Sheng Feng; Jian Zhang; Changhong Zhu; Shiguo Zhu; Jianxiu Yu
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.
Nature communications 2012;3():911.
2011: Kimberly A Lee; Tomas Mustelin; Jeffrey C Silva; Matthew P Stokes; Paul S Andrews; Roy A Black; Lisa P Hammerle; John R Doedens
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
The Journal of biological chemistry 2011;286(48):41530-8.
2011: Torkel Vang; Yuli Xie; Wallace H Liu; Dusica Vidović; Yidong Liu; Shuangding Wu; Deborah H. Smith; Alison Rinderspacher; Caty Chung; Gangli Gong; Tomas Mustelin; Donald W Landry; Robert C Rickert; Stephen Schuerer; Shi-Xian Deng; Lutz Tautz
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Journal of medicinal chemistry 2011;54(2):562-71.
2010: Lucia G Delogu; Stephanie M Stanford; Eugenio Santelli; Andrea Magrini; Antonio Bergamaschi; Khatereh Motamedchaboki; Nicola Rosato; Tomas Mustelin; Nunzio Bottini; Massimo Bottini
Carbon nanotube-based nanocarriers: the importance of keeping it clean.
Journal of nanoscience and nanotechnology 2010;10(8):5293-301.
2009: Shuangding Wu; Sofie Vossius; Souad Rahmouni; Ana V Miletic; Torkel Vang; Jesus Vazquez-Rodriguez; Fabio Cerignoli; Yutaka Arimura; Scott Williams; Tikva Hayes; Michel Moutschen; Stefan Vasile; Surya De; Tomas Mustelin; Lutz Tautz
Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
Journal of medicinal chemistry 2009;52(21):6716-23.
2009: Shuangding Wu; Massimo Bottini; Robert C Rickert; Tomas Mustelin; Lutz Tautz
In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation.
ChemMedChem 2009;4(3):440-4.
2009: Jianxiu Yu; Sharon S Zhang; Kan Saito; Scott Williams; Yutaka Arimura; Yuliang Ma; Yuehai Ke; Véronique Baron; Dan Mercola; Gen-Sheng Feng; Eileen D Adamson; Tomas Mustelin
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
The EMBO journal 2009;28(1):21-33.
2009: Dongmei Wu; Yuhong Pang; Yuehai Ke; Jianxiu Yu; Zhao He; Lutz Tautz; Tomas Mustelin; Sheng Ding; Ziwei Huang; Gen-Sheng Feng
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
PloS one 2009;4(3):e4914.
2009: María Luisa de la Puerta Turrillas; Antonio G Trinidad; María del Carmen Rodríguez; Jori Bogetz; Mariano Sánchez Crespo; Tomas Mustelin; Andrés Alonso; Yolanda Bayón
Characterization of new substrates targeted by Yersinia tyrosine phosphatase YopH.
PloS one 2009;4(2):e4431.
2008: Marie Fridberg; Sofia Kjellström; Lola Anagnostaki; Ingela Skogvall; Tomas Mustelin; Thomas Wiebe; Jenny L Persson; Michael Dictor; Anette Gjörloff Wingren
Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.
Pediatric hematology and oncology 2008;25(6):528-40.
2008: Yolanda Bayón; Antonio G Trinidad; María Luisa de la Puerta Turrillas; María Del Carmen Rodríguez; Jori Bogetz; Ana Rojas; José M De Pereda; Souad Rahmouni; Scott Williams; Shu-Ichi Matsuzawa; John C Reed; Mariano Sánchez Crespo; Tomas Mustelin; Andrés Alonso
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
The FEBS journal 2008;275(15):3900-10.
2008: Yutaka Arimura; Torkel Vang; Lutz Tautz; Scott Williams; Tomas Mustelin
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Molecular immunology 2008;45(11):3074-84.
2008: Matthew H Cato; Federica D'Annibale; David M Mills; Fabio Cerignoli; Marcia I Dawson; Enrico Bergamaschi; Nunzio Bottini; Andrea Magrini; Antonio Bergamaschi; Nicola Rosato; Robert C Rickert; Tomas Mustelin; Massimo Bottini
Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies.
Journal of nanoscience and nanotechnology 2008;8(5):2259-69.
2008: Rachel Henkens; Philippe Delvenne; Mohammad Arafa; Michel Moutschen; Mustapha Zeddou; Lutz Tautz; Jacques Boniver; Tomas Mustelin; Souad Rahmouni
Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.
BMC cancer 2008;8():147.
2008: Torkel Vang; Ana V Miletic; Yutaka Arimura; Lutz Tautz; Robert C Rickert; Tomas Mustelin
Protein tyrosine phosphatases in autoimmunity.
Annual review of immunology 2008;26():29-55.
2008: Karena A Kosco; Fabio Cerignoli; Scott Williams; Robert T Abraham; Tomas Mustelin
SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.
Molecular immunology 2008;45(2):510-22.
2007: Konstantina Nika; Lutz Tautz; Yutaka Arimura; Torkel Vang; Scott Williams; Tomas Mustelin
A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.
The Journal of biological chemistry 2007;282(49):36000-9.
2007: Marie Fridberg; Anna Servin; Lola Anagnostaki; Johan Linderoth; Mattias Berglund; Ola Söderberg; Gunilla Enblad; Anders Rosén; Tomas Mustelin; Mats Jerkeman; Jenny L Persson; Anette Gjörloff Wingren
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Leukemia & lymphoma 2007;48(11):2221-32.
2007: Massimo Bottini; Tomas Mustelin
Carbon materials: Nanosynthesis by candlelight.
Nature nanotechnology 2007;2(10):599-600.
2007: Richard Hoyt; Wei Zhu; Fabio Cerignoli; Andres Alonso; Tomas Mustelin; Michael David
Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3402-6.
2007: Torkel Vang; Ana V Miletic; Nunzio Bottini; Tomas Mustelin
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Autoimmunity 2007;40(6):453-61.
2007: Sergey A Shiryaev; Albert G Remacle; Boris I Ratnikov; Nicholas A Nelson; Alexei Y Savinov; Ge Wei; Massimo Bottini; Michele F Rega; Amelie Parent; Roxane Desjardins; Martin Fugere; Robert Day; Mojgan Sabet; Maurizio Pellecchia; Robert C Liddington; Jeffrey W Smith; Tomas Mustelin; Donald G Guiney; Michal Lebl; Alex Y Strongin
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
The Journal of biological chemistry 2007;282(29):20847-53.
2007: Irwan T Makagiansar; Scott Williams; Tomas Mustelin; William B Stallcup
Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration.
The Journal of cell biology 2007;178(1):155-65.
2007: Amanda M Opaluch; Pedro Aza-Blanc; Torkel Vang; Scott Williams; Lutz Tautz; Loribelle Milan; Tomas Mustelin
PTPome-wide functional RNA interference screening methods.
Methods (San Diego, Calif.) 2007;42(3):306-12.
2007: Lutz Tautz; Tomas Mustelin
Strategies for developing protein tyrosine phosphatase inhibitors.
Methods (San Diego, Calif.) 2007;42(3):250-60.
2007: Massimo Bottini; Fabio Cerignoli; David M Mills; Federica D'Annibale; Marilisa Leone; Nicola Rosato; Andrea Magrini; Surya De; Antonio Bergamaschi; Tomas Mustelin
Luminescent silica nanobeads: characterization and evaluation as efficient cytoplasmatic transporters for T-lymphocytes.
Journal of the American Chemical Society 2007;129(25):7814-23.
2007: Kan Saito; Lutz Tautz; Tomas Mustelin
The lipid-binding SEC14 domain.
Biochimica et biophysica acta 2007;1771(6):719-26.
2007: Marcia I Dawson; Zebin Xia; Gang Liu; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik B Patel; Sankari Arumugarajah; Mohammad Bhuiyan; Xiao-kun Zhang; Young-Hoon Han; William B Stallcup; Jun-ichi Fukushi; Tomas Mustelin; Lutz Tautz; Ying Su; Danni L Harris; Nahid Waleh; Peter D Hobbs; Ling Jong; Wan-Ru Chao; Leonard J Schiff; Brahma P Sani
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Journal of medicinal chemistry 2007;50(11):2622-39.
2007: Iddo Friedberg; Konstantina Nika; Lutz Tautz; Kan Saito; Fabio Cerignoli; Iddo Friedberg; Adam Godzik; Tomas Mustelin
Identification and characterization of DUSP27, a novel dual-specific protein phosphatase.
FEBS letters 2007;581(13):2527-33.
2007: Kan Saito; Scott Williams; Anna Bulankina; Stefan Höning; Tomas Mustelin
Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins.
The Journal of biological chemistry 2007;282(20):15170-8.
2007: Jesus Vazquez; Lutz Tautz; Jennifer J Ryan; Kristiina Vuori; Tomas Mustelin; Surya De
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.
Journal of medicinal chemistry 2007;50(9):2137-43.
2007: Timothy J Bauler; Elizabeth D Hughes; Yutaka Arimura; Tomas Mustelin; Thomas L Saunders; Philip D King
Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3680-7.
2007: Kazuhiro Sugihara; Daijiro Sugiyama; James Byrne; Don P Wolf; Kevin P Lowitz; Yoichi Kobayashi; Maryam Kabir-Salmani; Daita Nadano; Daisuke Aoki; Shiro Nozawa; Jun Nakayama; Tomas Mustelin; Erkki Ruoslahti; Naoto Yamaguchi; Michiko N Fukuda
Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3799-804.
2007: J Yu; Véronique Baron; Dan Mercola; Tomas Mustelin; Eileen D Adamson
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells.
Cell death and differentiation 2007;14(3):436-46.
2007: Annat F Ikin; Mirsada Causevic; Steve Pedrini; Lyndsey S Benson; Joseph Buxbaum; Toshiharu Suzuki; Simon Lovestone; Shigeki Higashiyama; Tomas Mustelin; Robert D Burgoyne; Sam Gandy
Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.
Molecular neurodegeneration 2007;2():23.
2007: Massimo Bottini; Federica D'Annibale; Andrea Magrini; Fabio Cerignoli; Yutaka Arimura; Marcia I Dawson; Enrico Bergamaschi; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes.
International journal of nanomedicine 2007;2(2):227-33.
2007: Tomas Mustelin
A brief introduction to the protein phosphatase families.
Methods in molecular biology (Clifton, N.J.) 2007;365():9-22.
2006: Tomas Mustelin
Challenges and optimism for nanoengineering.
Nanomedicine (London, England) 2006;1(4):383-5.
2006: Massimo Bottini; Fabio Cerignoli; Lutz Tautz; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Adsorption of streptavidin onto single-walled carbon nanotubes: application in fluorescent supramolecular nanoassemblies.
Journal of nanoscience and nanotechnology 2006;6(12):3693-8.
2006: Ashwani Khurana; Koh Nakayama; Scott Williams; Roger J Davis; Tomas Mustelin; Ze'ev Ronai
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
The Journal of biological chemistry 2006;281(46):35316-26.
2006: Fabio Cerignoli; Souad Rahmouni; Ze'ev Ronai; Tomas Mustelin
Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation.
Cell cycle (Georgetown, Tex.) 2006;5(19):2210-5.
2006: Tomas Mustelin
Immunology. Restless T cells sniff and go.
Science (New York, N.Y.) 2006;313(5795):1902-3.
2006: Massimo Bottini; Fabio Cerignoli; Marcia I Dawson; Andrea Magrini; Nicola Rosato; Tomas Mustelin
Full-length single-walled carbon nanotubes decorated with streptavidin-conjugated quantum dots as multivalent intracellular fluorescent nanoprobes.
Biomacromolecules 2006;7(8):2259-63.
2006: Nunzio Bottini; Torkel Vang; Francesco Cucca; Tomas Mustelin
Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
Seminars in immunology 2006;18(4):207-13.
2006: Tomas Mustelin
Are other protein tyrosine phosphatases than PTPN22 associated with autoimmunity?
Seminars in immunology 2006;18(4):254-60.
2006: Massimo Bottini; Andrea Magrini; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Dispersion of pristine single-walled carbon nanotubes in water by a thiolated organosilane: application in supramolecular nanoassemblies.
The journal of physical chemistry. B 2006;110(28):13685-8.
2006: Massimo Bottini; Andrea Magrini; Almerinda Di Venere; Stefano Bellucci; Marcia I Dawson; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Synthesis and characterization of supramolecular nanostructures of carbon nanotubes and ruthenium-complex Luminophores.
Journal of nanoscience and nanotechnology 2006;6(5):1381-6.
2006: Souad Rahmouni; Fabio Cerignoli; Andres Alonso; Toshiya Tsutji; Rachel Henkens; Changjun Zhu; Christine Louis-Dit-Sully; Michel Moutschen; Wei Jiang; Tomas Mustelin
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence.
Nature cell biology 2006;8(5):524-31.
2006: Konstantina Nika; Céline Charvet; Scott Williams; Lutz Tautz; Shane Bruckner; Souad Rahmouni; Nunzio Bottini; Stephen P Schoenberger; Gottfried Baier; Amnon Altman; Tomas Mustelin
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Molecular and cellular biology 2006;26(5):1806-16.
2006: Lutz Tautz; Surya De; Tomas Mustelin
Targeting the PTPome in human disease.
Expert opinion on therapeutic targets 2006;10(1):157-77.
2006: Massimo Bottini; Chidambara Balasubramanian; Marcia I Dawson; Antonio Bergamaschi; Stefano Bellucci; Tomas Mustelin
Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes.
The journal of physical chemistry. B 2006;110(2):831-6.
2006: Massimo Bottini; Shane Bruckner; Konstantina Nika; Nunzio Bottini; Stefano Bellucci; Andrea Magrini; Antonio Bergamaschi; Tomas Mustelin
Multi-walled carbon nanotubes induce T lymphocyte apoptosis.
Toxicology letters 2006;160(2):121-6.
2006: Tomas Mustelin
Protein tyrosine phosphatases in human disease.
Advances in experimental medicine and biology 2006;584():53-72.
2005: Yingchun Wang; Eric Vachon; Jinyi Zhang; Vera Cherepanov; Joshua Kruger; Jun Li; Kan Saito; Patrick Shannon; Nunzio Bottini; Huong Huynh; Heyu Ni; Hong Yang; Colin McKerlie; Sue Quaggin; Zhizhuang Joe Zhao; Philip A Marsden; Tomas Mustelin; Katherine A Siminovitch; Gregory P Downey
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.
The Journal of experimental medicine 2005;202(11):1587-97.
2005: Torkel Vang; Mauro Congia; Maria Doloretta Macis; Lucia Musumeci; Valeria Orrú; Patrizia Zavattari; Konstantina Nika; Lutz Tautz; Kjetil Taskén; Francesco Cucca; Tomas Mustelin; Nunzio Bottini
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Nature genetics 2005;37(12):1317-9.
2005: Tomas Mustelin; Lutz Tautz; Rebecca Page
Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
Journal of molecular biology 2005;354(1):150-63.
2005: Maria Merkulova; Huong Huynh; Vitaly Radchenko; Kan Saito; Valery Lipkin; Tatiana Shuvaeva; Tomas Mustelin
Secretion of the mammalian Sec14p-like phosphoinositide-binding p45 protein.
The FEBS journal 2005;272(21):5595-605.
2005: Anna Maria Al-Khouri; Yuliang Ma; Summanuna H Togo; Scott Williams; Tomas Mustelin
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
The Journal of biological chemistry 2005;280(42):35195-202.
2005: Lucia Musumeci; Cristina Bongiorni; Lutz Tautz; Robert A Edwards; Andrei Osterman; Marta Perego; Tomas Mustelin; Nunzio Bottini
Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis.
Journal of bacteriology 2005;187(14):4945-56.
2005: Armando V Mena-Duran; Summanuna H Togo; Lyudmila Bazhenova; José Cervera; Kelly Bethel; Maria L Senent; Jorge Nieva; Guillermo F Sanz; Miguel A Sanz; Alan Saven; Tomas Mustelin
SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor.
British journal of haematology 2005;129(6):791-4.
2005: Eileen D Adamson; Jianxiu Yu; Tomas Mustelin
Co-factors p300 and CBP catch Egr1 in their network.
The Prostate 2005;63(4):407-10.
2005: Ivan Mijakovic; Lucia Musumeci; Lutz Tautz; Dina Petranovic; Robert A Edwards; Peter R Jensen; Tomas Mustelin; Josef Deutscher; Nunzio Bottini
In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE.
Journal of bacteriology 2005;187(10):3384-90.
2005: Vibeke Sundvold-Gjerstad; Stine Granum; Tomas Mustelin; Thorny C B Andersen; Tone Berge; Michael J Shapiro; Virginia S Shapiro; Anne Spurkland; Tor Lea
The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity.
European journal of immunology 2005;35(5):1612-20.
2005: Shane Bruckner; Souad Rhamouni; Lutz Tautz; Jean-Bernard Denault; Andres Alonso; Barbara Becattini; Guy S Salvesen; Tomas Mustelin
Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells.
The Journal of biological chemistry 2005;280(11):10388-94.
2005: Lutz Tautz; Shane Bruckner; Sina Sareth; Andres Alonso; Jori Bogetz; Nunzio Bottini; Surya De; Tomas Mustelin
Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds.
The Journal of biological chemistry 2005;280(10):9400-8.
2005: Souad Rahmouni; Torkel Vang; Andres Alonso; Scott Williams; Marianne J B van Stipdonk; Chiara Soncini; Michel Moutschen; Stephen P Schoenberger; Tomas Mustelin
Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.
Molecular and cellular biology 2005;25(6):2227-41.
2005: Massimo Bottini; Lutz Tautz; Huong Huynh; Edward Monosov; Nunzio Bottini; Marcia I Dawson; Stefano Bellucci; Tomas Mustelin
Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles.
Chemical communications (Cambridge, England) 2005;(6):758-60.
2005: Fariborz Nasertorabi; Andres Alonso; Scott W Rogers; Tomas Mustelin; Kristiina Vuori; Lars Liljas; Kathryn R Ely
Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):174-7.
2005: Tomas Mustelin; Torkel Vang; Nunzio Bottini
Protein tyrosine phosphatases and the immune response.
Nature reviews. Immunology 2005;5(1):43-57.
2004: Irwan T Makagiansar; Scott Williams; Kimberlee Dahlin-Huppe; Jun-ichi Fukushi; Tomas Mustelin; William B Stallcup
Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.
The Journal of biological chemistry 2004;279(53):55262-70.
2004: Surya De; Barbara Becattini; Kevin J Crowell; Roberto Fattorusso; Martino Forino; Marco Fragai; Dawoon Jung; Tomas Mustelin; Lutz Tautz
NMR-based techniques in the hit identification and optimisation processes.
Expert opinion on therapeutic targets 2004;8(6):597-611.
2004: Hilde Abrahamsen; George S Baillie; Jacob Ngai; Torkel Vang; Konstantina Nika; Anja Ruppelt; Tomas Mustelin; Manuela Zaccolo; Miles D Houslay; Kjetil Taskén
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4847-58.
2004: Huong Huynh; Nunzio Bottini; Scott Williams; Vera Cherepanov; Lucia Musumeci; Kan Saito; Shane Bruckner; Eric Vachon; Xiaodong Wang; Joshua Kruger; Chung-Wai Chow; Surya De; Edward Monosov; Peter A Greer; William Trimble; Gregory P Downey; Tomas Mustelin
Control of vesicle fusion by a tyrosine phosphatase.
Nature cell biology 2004;6(9):831-9.
2004: Andres Alonso; Stephen Burkhalter; Joanna Sasin; Lutz Tautz; Jori Bogetz; Huong Huynh; Meire C D Bremer; Leslie J Holsinger; Adam Godzik; Tomas Mustelin
The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.
The Journal of biological chemistry 2004;279(34):35768-74.
2004: Torkel Vang; Hilde Abrahamsen; Sondre Myklebust; Jorrit Enserink; Hans Prydz; Tomas Mustelin; Mohammed Amarzguioui; Kjetil Tasken
Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells.
European journal of immunology 2004;34(8):2191-9.
2004: Andres Alonso; Sonoko Narisawa; Jori Bogetz; Lutz Tautz; Radinka Hadzic; Huong Huynh; Scott Williams; Anette Gjörloff-Wingren; Meire C D Bremer; Leslie J Holsinger; José Luis Millan; Tomas Mustelin
VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
The Journal of biological chemistry 2004;279(31):32586-91.
2004: Tomas Mustelin; Andres Alonso; Nunzio Bottini; Huong Huynh; Souad Rahmouni; Konstantina Nika; Christine Louis-Dit-Sully; Lutz Tautz; Summanuna H Togo; Shane Bruckner; Armando V Mena-Duran; Anna Maria Al-Khouri
Protein tyrosine phosphatases in T cell physiology.
Molecular immunology 2004;41(6-7):687-700.
2004: Andres Alonso; Joanna Sasin; Nunzio Bottini; Iddo Friedberg; Iddo Friedberg; Andrei Osterman; Adam Godzik; Tony Hunter; Jack Dixon; Tomas Mustelin
Protein tyrosine phosphatases in the human genome.
Cell 2004;117(6):699-711.
2004: Nunzio Bottini; Lucia Musumeci; Andres Alonso; Souad Rahmouni; Konstantina Nika; Masoud Rostamkhani; James MacMurray; Gian Franco Meloni; Paola Lucarelli; Surya De; George S Eisenbarth; David E Comings; Tomas Mustelin
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Nature genetics 2004;36(4):337-8.
2004: Konstantina Nika; Huong Hyunh; Scott Williams; Surojit Paul; Nunzio Bottini; Kjetil Taskén; Paul J Lombroso; Tomas Mustelin
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location.
The Biochemical journal 2004;378(Pt 2):335-42.
2004: Andres Alonso; Nunzio Bottini; Shane Bruckner; Souad Rahmouni; Scott Williams; Stephen P Schoenberger; Tomas Mustelin
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
The Journal of biological chemistry 2004;279(6):4922-8.
2003: Huong Huynh; Xiaodong Wang; Weizhong Li; Nunzio Bottini; Scott Williams; Konstantina Nika; Hisamitsu Ishihara; Adam Godzik; Tomas Mustelin
Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6661-71.
2003: Yaoming Yang; Patricia Villain; Tomas Mustelin; Clément Couture
Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells.
Molecular and cellular biology 2003;23(21):7667-77.
2003: Fubo Liang; Zhonghui Huang; Seung-Yub Lee; Jiao Liang; Maya I Ivanov; Andres Alonso; James B Bliska; David S Lawrence; Tomas Mustelin; Zhong-Yin Zhang
Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.
The Journal of biological chemistry 2003;278(43):41734-41.
2003: Sheraz Yaqub; Hilde Abrahamsen; Bastian Zimmermann; Natalya Kholod; Knut Martin Torgersen; Tomas Mustelin; Friedrich W Herberg; Kjetil Taskén; Torkel Vang
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain.
The Biochemical journal 2003;372(Pt 1):271-8.
2003: Tomas Mustelin; Kjetil Taskén
Positive and negative regulation of T-cell activation through kinases and phosphatases.
The Biochemical journal 2003;371(Pt 1):15-27.
2003: Tomas Mustelin; Souad Rahmouni; Nunzio Bottini; Andres Alonso
Role of protein tyrosine phosphatases in T cell activation.
Immunological reviews 2003;191():139-47.
2003: Andres Alonso; Souad Rahmouni; Scott Williams; Marianne J B van Stipdonk; Lukasz Jaroszewski; Adam Godzik; Robert T Abraham; Stephen P Schoenberger; Tomas Mustelin
Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
Nature immunology 2003;4(1):44-8.
2002: Johannes Lundin Brockdorff; Anders Woetmann; Tomas Mustelin; Keld Kaltoft; Qian Zhang; Mariusz A Wasik; Carsten Röpke; Niels Ødum
SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells.
Cytokine 2002;20(4):141-7.
2002: Wei Zhu; Tomas Mustelin; Michael David
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.
The Journal of biological chemistry 2002;277(39):35787-90.
2002: Nunzio Bottini; Lavinia Stefanini; Scott Williams; Andres Alonso; Thomas Jascur; Robert T Abraham; Clément Couture; Tomas Mustelin
Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).
The Journal of biological chemistry 2002;277(27):24220-4.
2002: Diana Birle; Nunzio Bottini; Scott Williams; Huong Huynh; Ian deBelle; Eileen D Adamson; Tomas Mustelin
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):286-91.
2002: Randy Shen; Ying-Bin Ouyang; Cheng-Kui Qu; Andres Alonso; Lindsey Sperzel; Tomas Mustelin; Mark H Kaplan; Gen-Sheng Feng
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
Molecular and cellular biology 2002;22(10):3230-6.
2002: Xiaodong Wang; Huong Huynh; Anette Gjörloff-Wingren; Edward Monosov; Mats Stridsberg; Minoru Fukuda; Tomas Mustelin
Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4612-9.
2002: Tomas Mustelin; Robert T Abraham; Christopher E Rudd; Andres Alonso; Joseph J Merlo
Protein tyrosine phosphorylation in T cell signaling.
Frontiers in bioscience : a journal and virtual library 2002;7():d918-69.
2002: Andres Alonso; Joseph J Merlo; Songqing Na; Natalya Kholod; Lukasz Jaroszewski; Alexei Kharitonenkov; Scott Williams; Adam Godzik; James D Posada; Tomas Mustelin
Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).
The Journal of biological chemistry 2002;277(7):5524-8.
2002: Tomas Mustelin; Tony Hunter
Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha.
Science's STKE : signal transduction knowledge environment 2002;2002(115):pe3.
2002: Nunzio Bottini; Egidio Bottini; Fulvia Gloria-Bottini; Tomas Mustelin
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
Archivum immunologiae et therapiae experimentalis 2002;50(2):95-104.
2002: Tomas Mustelin
Keeping the T-cell immune response in balance: role of protein tyrosine phosphatases in autoimmunity.
Current directions in autoimmunity 2002;5():176-90.
2002: Tomas Mustelin; G S Feng; Nunzio Bottini; Andres Alonso; Natalya Kholod; Diana Birle; Joseph J Merlo; Huong Huynh
Protein tyrosine phosphatases.
Frontiers in bioscience : a journal and virtual library 2002;7():d85-142.
2001: Thierry Virolle; Eileen D Adamson; Véronique Baron; Diana Birle; Dan Mercola; Tomas Mustelin; Ian De Belle
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling.
Nature cell biology 2001;3(12):1124-8.
2001: Knut Martin Torgersen; Torkel Vang; Hilde Abrahamsen; Sheraz Yaqub; Václav Horejsí; B Schraven; Bent Rolstad; Tomas Mustelin; Kjetil Taskén
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts.
The Journal of biological chemistry 2001;276(31):29313-8.
2001: Torkel Vang; Knut Martin Torgersen; V Sundvold; M Saxena; Finn Olav Levy; Bjørn S Skålhegg; V Hansson; Tomas Mustelin; Kjetil Taskén
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.
The Journal of experimental medicine 2001;193(4):497-507.
2001: Andres Alonso; M Saxena; Scott Williams; Tomas Mustelin
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
The Journal of biological chemistry 2001;276(7):4766-71.
2001: E Parra; Tomas Mustelin; M Dohlsten; Dan Mercola
Identification of a CD28 response element in the CD40 ligand promoter.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2437-43.
2001: Johannes Brockdorff; Haihua Gu; Tomas Mustelin; Keld Kaltoft; Carsten Geisler; Carsten Röpke; Niels Ødum
Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a.
Experimental and clinical immunogenetics 2001;18(2):86-95.
2000: M Saxena; Tomas Mustelin
Extracellular signals and scores of phosphatases: all roads lead to MAP kinase.
Seminars in immunology 2000;12(4):387-96.
2000: Anette Gjörloff-Wingren; M Saxena; S Han; Xiaodong Wang; Andres Alonso; M Renedo; P Oh; Scott Williams; J Schnitzer; Tomas Mustelin
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
European journal of immunology 2000;30(8):2412-21.
2000: Johannes Brockdorff; Morten Nielsen; Keld Kaltoft; Tomas Mustelin; Carsten Röpke; A Svejaard; Carsten Geisler; Niels Odum
Lck is involved in interleukin-2 induced proliferation but not cell survival in human T cells through a MAP kinase-independent pathway.
European cytokine network 2000;11(2):225-31.
2000: S Han; Scott Williams; Tomas Mustelin
Cytoskeletal protein tyrosine phosphatase PTPH1 reduces T cell antigen receptor signaling.
European journal of immunology 2000;30(5):1318-25.
2000: Xiaodong Wang; Anette Gjörloff-Wingren; M Saxena; N Pathan; John C Reed; Tomas Mustelin
The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1934-9.
1999: Anette Gjörloff-Wingren; M Saxena; Scott Williams; D Hammi; Tomas Mustelin
Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP.
European journal of immunology 1999;29(12):3845-54.
1999: M Saxena; Scott Williams; K Taskén; Tomas Mustelin
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.
Nature cell biology 1999;1(5):305-11.
1999: Tomas Mustelin; J Brockdorff; L Rudbeck; Anette Gjörloff-Wingren; S Han; X Wang; Pankaj Tailor; M Saxena
The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling.
Cellular signalling 1999;11(9):637-50.
1999: J Brockdorff; Scott Williams; Clément Couture; Tomas Mustelin
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
European journal of immunology 1999;29(8):2539-50.
1999: Pankaj Tailor; J Gilman; Scott Williams; Tomas Mustelin
A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing.
European journal of biochemistry / FEBS 1999;262(2):277-82.
1999: M Saxena; Scott Williams; J Brockdorff; J Gilman; Tomas Mustelin
Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
The Journal of biological chemistry 1999;274(17):11693-700.
1999: S Kasibhatla; Pankaj Tailor; N Bonefoy-Berard; Tomas Mustelin; Amnon Altman; Arun Fotedar
Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1.
Molecular and cellular biology 1999;19(3):2021-31.
1998: Tomas Mustelin; J Brockdorff; Anette Gjörloff-Wingren; Pankaj Tailor; S Han; X Wang; M Saxena
Lymphocyte activation: the coming of the protein tyrosine phosphatases.
Frontiers in bioscience : a journal and virtual library 1998;3():D1060-96.
1998: M Saxena; Scott Williams; J Gilman; Tomas Mustelin
Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP).
The Journal of biological chemistry 1998;273(25):15340-4.
1998: M von Willebrand; Scott Williams; Pankaj Tailor; Tomas Mustelin
Phosphorylation of the Grb2- and phosphatidylinositol 3-kinase p85-binding p36/38 by Syk in Lck-negative T cells.
Cellular signalling 1998;10(6):407-13.
1998: M von Willebrand; Scott Williams; M Saxena; J Gilman; Pankaj Tailor; Thomas Jascur; Gustavo Amarante-Mendes; Douglas R Green; Tomas Mustelin
Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.
The Journal of biological chemistry 1998;273(7):3994-4000.
1997: Gustavo Amarante-Mendes; Thomas Jascur; W K Nishioka; Tomas Mustelin; Douglas R Green
Bcr - Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity.
Cell death and differentiation 1997;4(7):548-54.
1997: Morten Nielsen; Keld Kaltoft; M Nordahl; Carsten Röpke; Carsten Geisler; Tomas Mustelin; P Dobson; Arne Svejgaard; Niels Odum
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6764-9.
1997: D M Farschon; C Couture; Tomas Mustelin; Donald D Newmeyer
Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction.
The Journal of cell biology 1997;137(5):1117-25.
1997: Clément Couture; Scott Williams; N Gauthier; Pankaj Tailor; Tomas Mustelin
Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase.
European journal of biochemistry / FEBS 1997;246(2):447-51.
1997: Thomas Jascur; J Gilman; Tomas Mustelin
Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells.
The Journal of biological chemistry 1997;272(22):14483-8.
1997: Scott Williams; Clément Couture; J Gilman; Thomas Jascur; Marcel Deckert; Amnon Altman; Tomas Mustelin
Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk.
European journal of biochemistry / FEBS 1997;245(1):84-90.
1997: Pankaj Tailor; J Gilman; Scott Williams; Clément Couture; Tomas Mustelin
Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.
The Journal of biological chemistry 1997;272(9):5371-4.
1996: Marcel Deckert; S Tartare-Deckert; Clément Couture; Tomas Mustelin; Amnon Altman
Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.
Immunity 1996;5(6):591-604.
1996: Clément Couture; Zhou Songyang; Thomas Jascur; Scott Williams; Pankaj Tailor; L C Cantley; Tomas Mustelin
Regulation of the Lck SH2 domain by tyrosine phosphorylation.
The Journal of biological chemistry 1996;271(40):24880-4.
1996: G Zenner; T Vorherr; Tomas Mustelin; P Burn
Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain.
Journal of cellular biochemistry 1996;63(1):94-103.
1996: Clément Couture; Marcel Deckert; Scott Williams; F O Russo; Amnon Altman; Tomas Mustelin
Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck.
The Journal of biological chemistry 1996;271(39):24294-9.
1996: Pankaj Tailor; Thomas Jascur; Scott Williams; M von Willebrand; Clément Couture; Tomas Mustelin
Involvement of Src-homology-2-domain-containing protein-tyrosine phosphatase 2 in T cell activation.
European journal of biochemistry / FEBS 1996;237(3):736-42.
1996: M Von Willebrand; Thomas Jascur; N Bonnefoy-Bérard; H Yano; Amnon Altman; Y Matsuda; Tomas Mustelin
Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2.
European journal of biochemistry / FEBS 1996;235(3):828-35.
1995: G Zenner; J Dirk zur Hausen; P Burn; Tomas Mustelin
Towards unraveling the complexity of T cell signal transduction.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(11):967-75.
1995: N Bonnefoy-Bérard; Yun-Cai Liu; M von Willebrand; A Sung; Chris Elly; Tomas Mustelin; H Yoshida; KIMISHIGE ISHIZAKA; Amnon Altman
Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10142-6.
1995: Tomas Mustelin; Scott Williams; Pankaj Tailor; Clément Couture; G Zenner; P Burn; J D Ashwell; Amnon Altman
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.
European journal of immunology 1995;25(4):942-6.
1994: C Oetken; M von Willebrand; A Marie-Cardine; Tiina Pessa-Morikawa; A Ståhls; S Fisher; Tomas Mustelin
Induction of hyperphosphorylation and activation of the p56lck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor.
Molecular immunology 1994;31(17):1295-302.
1994: A Ståhls; G E Liwszyc; Clément Couture; Tomas Mustelin; Leif C Andersson
Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase.
European journal of immunology 1994;24(10):2491-6.
1994: Tomas Mustelin
T cell antigen receptor signaling: three families of tyrosine kinases and a phosphatase.
Immunity 1994;1(5):351-6.
1994: Clément Couture; Gottfried Baier; Amnon Altman; Tomas Mustelin
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5301-5.
1994: C Oetken; Clément Couture; M Bergman; N Bonnefoy-Bérard; Scott Williams; Kari Alitalo; P Burn; Tomas Mustelin
TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain.
Oncogene 1994;9(6):1625-31.
1994: M von Willebrand; Gottfried Baier; Clément Couture; P Burn; Tomas Mustelin
Activation of phosphatidylinositol-3-kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase.
European journal of immunology 1994;24(1):234-8.
1993: Tomas Mustelin; P Burn
Regulation of src family tyrosine kinases in lymphocytes.
Trends in biochemical sciences 1993;18(6):215-20.
1992: C Oetken; Tiina Pessa-Morikawa; M Autero; Leif C Andersson; Tomas Mustelin
Reduced tyrosine phosphorylation in polyamine-starved cells.
Experimental cell research 1992;202(2):370-5.
1992: C Oetken; M von Willebrand; M Autero; Tapani Ruutu; Leif C Andersson; Tomas Mustelin
Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells.
European journal of haematology 1992;49(4):208-14.
1992: M Bergman; Tomas Mustelin; C Oetken; J Partanen; N A Flint; Kurt Amrein; M Autero; P Burn; Kari Alitalo
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
The EMBO journal 1992;11(8):2919-24.
1992: Tomas Mustelin; Tiina Pessa-Morikawa; M Autero; M Gassmann; Leif C Andersson; Carl G Gahmberg; P Burn
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.
European journal of immunology 1992;22(5):1173-8.
1992: T Nordström; Tomas Mustelin; Tiina Pessa-Morikawa; Leif C Andersson
Modulation of calcium fluxes in Jurkat T cells by myristic acid. Inhibition is independent of membrane potential and intracellular pH.
The Biochemical journal 1992;283 ( Pt 1)():113-8.
1992: A Ståhls; M Heiskala; Tomas Mustelin; Leif C Andersson
Activation of natural killer cells via the Fc gamma RIII (CD16) requires initial tyrosine phosphorylation.
European journal of immunology 1992;22(2):611-4.
1991: Tiina Pessa-Morikawa; T Nordström; Tomas Mustelin; Leif C Andersson
GTP-binding membrane proteins in activated and differentiating T cells.
Biochemical and biophysical research communications 1991;178(1):138-44.
1991: T Nordström; C Lindqvist; A Ståhls; Tomas Mustelin; Leif C Andersson
Inhibition of CD3-induced Ca2+ signals in Jurkat T-cells by myristic acid.
Cell calcium 1991;12(7):449-55.
1990: T Nordström; A Ståhls; Tiina Pessa-Morikawa; Tomas Mustelin; Leif C Andersson
Phorbol 12-myristate 13-acetate (TPA) blocks CD3-mediated Ca2+ mobilization in Jurkat T cells independently of protein kinase C activation.
Biochemical and biophysical research communications 1990;173(1):396-400.
1990: A V Iivanainen; C Lindqvist; Tomas Mustelin; Leif C Andersson
Phosphotyrosine phosphatases are involved in reversion of T lymphoblastic proliferation.
European journal of immunology 1990;20(11):2509-12.
1990: Tiina Pessa-Morikawa; Tomas Mustelin; Leif C Andersson
Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2690-5.
1988: Tomas Mustelin; S P Lapinjoki; Jukka Gynther; Leif C Andersson
Contaminant found in antiserum.
Cell 1988;52(5):640.
1988: Tomas Mustelin; T Pessa; S Lapinjoki; Jukka Gynther; T Järvinen; T Eloranta; Leif C Andersson
Two phases of ornithine decarboxylase activation during lymphocyte mitogenesis.
Advances in experimental medicine and biology 1988;250():301-13.
1987: Tomas Mustelin; H Pösö; A Ståhls; T Eloranta; Leif C Andersson
Transduction of mitogenic signals in T lymphocytes. Role of inositol phospholipids for the rapid activation of ornithine decarboxylase.
Scandinavian journal of immunology 1987;26(3):287-94.
1987: Tomas Mustelin; H Pösö; S P Lapinjoki; Jukka Gynther; Leif C Andersson
Growth signal transduction: rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown.
Cell 1987;49(2):171-6.
1986: Tomas Mustelin; H Pösö; Leif C Andersson
Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes.
The EMBO journal 1986;5(12):3287-90.
1986: Tomas Mustelin; H Pösö; A Iivanainen; Leif C Andersson
myo-Inositol reverses Li+-induced inhibition of phosphoinositide turnover and ornithine decarboxylase induction during early lymphocyte activation.
European journal of immunology 1986;16(7):859-61.