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Kiran Musunuru

Research Profile

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Publications

TOP 3
Qiurong Ding; Leoníe A Oostrom; Stephanie N Regan; Yulei Xia; Chad A Cowan; Kiran Musunuru
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs.
Kiran Musunuru
Enduring mystery of the chromosome 9p21.3 locus.
Qiurong Ding; Emmanuel Figueroa; Max Friesen; Rajat M Gupta; William T Hendriks; Kevin Kim; Nicolas Kuperwasser; Youn-Kyoung Lee; Torsten B Meissner; Annie Moisan; Daniel L Motola; Kiran Musunuru; Lee F Peng; Derek T Peters; Lee L Rubin; Esperance A K Schaefer; Robert T Schinzel; Alexander Tang; Marta Trevisan; Adrian Veres; Amy Wann; Fang Xia; Yulei Xia; Feng Zhang; Tim Ahfeldt; Eric Banks; Raymond T Chung; Laurence Daheron; Chad A Cowan
A TALEN genome-editing system for generating human stem cell-based disease models.

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All Publications

2013: Qiurong Ding; Leoníe A Oostrom; Stephanie N Regan; Yulei Xia; Chad A Cowan; Kiran Musunuru
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs.
Cell stem cell 2013;12(4):393-4.
2013: Kiran Musunuru
Enduring mystery of the chromosome 9p21.3 locus.
Circulation. Cardiovascular genetics 2013;6(2):224-5.
2013: Qiurong Ding; Emmanuel Figueroa; Max Friesen; Rajat M Gupta; William T Hendriks; Kevin Kim; Nicolas Kuperwasser; Youn-Kyoung Lee; Torsten B Meissner; Annie Moisan; Daniel L Motola; Kiran Musunuru; Lee F Peng; Derek T Peters; Lee L Rubin; Esperance A K Schaefer; Robert T Schinzel; Alexander Tang; Marta Trevisan; Adrian Veres; Amy Wann; Fang Xia; Yulei Xia; Feng Zhang; Tim Ahfeldt; Eric Banks; Raymond T Chung; Laurence Daheron; Chad A Cowan
A TALEN genome-editing system for generating human stem cell-based disease models.
Cell stem cell 2013;12(2):238-51.
2013: John J Ryan; Kiran Musunuru; Siddharth K Prakash
Top advances in functional genomics and translational biology for 2012.
Circulation. Cardiovascular genetics 2013;6(1):132-4.
2012: Derek T Peters; Kiran Musunuru
Functional evaluation of genetic variation in complex human traits.
Human molecular genetics 2012;21(R1):R18-23.
2012: Kiran Musunuru
Transforming growth factor β2 mutations and familial thoracic aortic aneurysms.
Circulation. Cardiovascular genetics 2012;5(5):593-4.
2012: Valentin Fuster; Dominick J Angiolillo; Eric R Bates; Deepak L Bhatt; Robert M Califf; David J Cohen; Barry S Coller; Bruce Furie; W Keith Hoots; Jean-Sebastien Hulot; Kenneth G Mann; Jessica L Mega; Alan D Michelson; Kiran Musunuru; Christopher J O'Donnell; Matthew J Price; Yves D Rosenberg; Marc S Sabatine; David J Schneider; Daniel I Simon; Jeffrey I Weitz; Marlene S Williams; Ahmed A K Hasan
Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group.
Circulation 2012;126(13):1645-62.
2012: Kiran Musunuru
Induction of cardiomyocytes from cardiac fibroblasts.
Circulation. Cardiovascular genetics 2012;5(4):481-2.
2012: Alanna Strong; Alan R Tall; Margaret Ye Wang; Katherine V Sachs; Ding Ai; Eric T Alexander; Qiurong Ding; Andrew C Edmondson; Edward A Fisher; Liang Guo; Sekar Kathiresan; Arthi Kumaravel; Xiaoyu Li; Sissel Lund-Katz; John S Millar; Carlos R Morales; Kiran Musunuru; David Nguyen; Michael C Phillips; Daniel J Rader
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
The Journal of clinical investigation 2012;122(8):2807-16.
2012: Hongmei Mou; Kiran Musunuru; Tim Ahfeldt; Chad Cowan; Konstantin Izvolsky; Allen Lapey; Richard Sherwood; Leonard Sicilian; John Wain; Rui Zhao; Jayaraj Rajagopal
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs.
Cell stem cell 2012;10(4):385-97.
2012: Kiran Musunuru; Christopher Newton-Cheh; Dina N Paltoo; Dan M Roden; Yves Rosenberg; Jay G Wohlgemuth; Issam Zineh; Robin Boineau; Michael R Bristow; Timothy A McCaffrey; Ahmed A K Hasan
Cardiovascular pharmacogenomics: current status and future directions-report of a national heart, lung, and blood institute working group.
Journal of the American Heart Association 2012;1(2):e000554.
2012: Kiran Musunuru
Exome sequencing to identify novel genes in hypertension.
Circulation. Cardiovascular genetics 2012;5(2):267-8.
2012: Laurie H Glimcher; Olle Lindvall; Kiran Musunuru; Suzanne Topalian; Vince Aguirre; Anthony S Fauci
Translating research into therapies.
Cell 2012;148(6):1077-8.
2012: Andreas S Barth; Jane Francisca Ferguson; Kiran Musunuru
Top advances in functional genomics and translational biology for 2011.
Circulation. Cardiovascular genetics 2012;5(1):143-5.
2012: Tim Ahfeldt; Heba Al-Siddiqi; Raymond Camahort; Clary B Clish; Alicia Cowley; Rahul C Deo; Robert E Gerszten; David Hendrickson; Adam Kaplan; Frank H Lau; Youn-Kyoung Lee; David H Lum; Greg Mowrer; Kiran Musunuru; Matthias Nahrendorf; Eugene P Rhee; John L Rinn; Robert T Schinzel; Jennifer Shay; Tony Shen; Fang Xia; Chad A Cowan
Programming human pluripotent stem cells into white and brown adipocytes.
Nature cell biology 2012;14(2):209-19.
2012: Kiran Musunuru; Jose M Ordovas; George J Papanicolaou; Bruce M Psaty; Christie M Ballantyne; Eric Boerwinkle; Sarah Buxbaum; L Adrienne Cupples; Myriam Fornage; Stacey B Gabriel; Nicole L Glazer; Sekar Kathiresan; Ronald M Krauss; Guillaume Lettre; Kiang Liu; Susan Redline; Stephen S Rich; Simon P R Romaine; Jerome I Rotter; Pamela J Schreiner; Herman A Taylor; Michael Y Tsai; Kelly A Volcik; James G Wilson; Daniel J Rader
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.
PloS one 2012;7(5):e36473.
2011: Kiran Musunuru
Lack of association of KIF6 genotype with vascular disease and statin response.
Circulation. Cardiovascular genetics 2011;4(4):467-8.
2011: Kiran Musunuru
Current role of pharmacogenomics in cardiovascular medicine.
Current treatment options in cardiovascular medicine 2011;13(4):302-12.
2011: Marianna Teplova; Jikui Song; Alexei Teplov; Ruben Abagyan; Stephen K Burley; Jennifer C Darnell; Robert B Darnell; Min Lu; Lucy Malinina; Kiran Musunuru; Dinshaw J Patel
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure (London, England : 1993) 2011;19(7):930-44.
2011: Kiran Musunuru
Regulatory elements in noncoding DNA in the chromosome 9p21 locus.
Circulation. Cardiovascular genetics 2011;4(3):330-1.
2010: Kiran Musunuru; James P Pirruccello; Ron Do; Gina M Peloso; Candace Guiducci; Carrie Sougnez; Kiran V Garimella; Sheila Fisher; Justin Abreu; Andrew J Barry; Tim Fennell; Eric Banks; Lauren Ambrogio; Kristian Cibulskis; Andrew Kernytsky; Elena Gonzalez; Nicholas Rudzicz; James C Engert; Mark A DePristo; Mark J Daly; Jonathan C Cohen; Helen H Hobbs; David Altshuler; Gustav Schonfeld; Stacey B Gabriel; Pin Yue; Sekar Kathiresan
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.
The New England journal of medicine 2010;363(23):2220-7.
2010: R Gupta; K Ejebe; Javed Butler; G Lettre; H Lyon; C Guiducci; R Wilks; F Bennett; T Forrester; B Tayo; Kiran Musunuru; Joel N Hirschhorn; Sekar Kathiresan; R S Cooper; C A McKenzie
Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.
Human genetics 2010;128(5):557-61.
2010: Kiran Musunuru; Wendy S Post; WILLIAM HERZOG; Haiqing Shen; Jeffrey R O'Connell; Patrick F McArdle; Kathleen A Ryan; Quince Gibson; Yu-Ching Cheng; Elizabeth Clearfield; Andrew D Johnson; Geoffrey Tofler; Qiong Yang; Christopher J O'Donnell; Diane M Becker; Lisa R Yanek; Lewis C Becker; Nauder Faraday; Lawrence F Bielak; Patricia A Peyser; Alan R Shuldiner; Braxton D Mitchell
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.
Circulation. Cardiovascular genetics 2010;3(5):445-53.
2010: Kiran Musunuru
Atherogenic dyslipidemia: cardiovascular risk and dietary intervention.
Lipids 2010;45(10):907-14.
2010: Kiran Musunuru; Sekar Kathiresan
Genetics of coronary artery disease.
Annual review of genomics and human genetics 2010;11():91-108.
2010: Kiran Musunuru; Alanna Strong; Maria Frank-Kamenetsky; Noemi E Lee; Tim Ahfeldt; Katherine V Sachs; Xiaoyu Li; Hui Li; Nicolas Kuperwasser; Vera M Ruda; James P Pirruccello; Brian Muchmore; Ludmila Prokunina-Olsson; Jennifer L Hall; Eric E Schadt; Carlos R Morales; Sissel Lund-Katz; Michael C Phillips; Jamie Wong; William Cantley; Timothy Racie; Kenechi G Ejebe; Marju Orho-Melander; Olle Melander; Victor Koteliansky; Kevin Fitzgerald; Ronald M Krauss; Chad A Cowan; Sekar Kathiresan; Daniel J Rader
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.
Nature 2010;466(7307):714-9.
2010: Kim A Eagle; Geoffrey S Ginsburg; Kiran Musunuru; William C Aird; Robert S Balaban; Susan K Bennett; Roger S Blumenthal; Shaun R Coughlin; Karina W Davidson; Edward D Frohlich; Philip Greenland; Gail P Jarvik; Peter Libby; Carl J Pepine; Jeremy N Ruskin; Arthur E Stillman; Jennifer E Van Eyk; H Eser Tolunay; Cheryl L McDonald; Sidney C Smith
Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group.
Circulation 2010;121(12):1447-54.
2010: Kiran Musunuru; Ibrahim J Domian; Kenneth R Chien
Stem cell models of cardiac development and disease.
Annual review of cell and developmental biology 2010;26():667-87.
2009: Julie B Zang; Elena D Nosyreva; Corinne M Spencer; Lenora J Volk; Kiran Musunuru; Ru Zhong; Elizabeth F Stone; Lisa A Yuva-Paylor; Kimberly M Huber; Richard Paylor; Jennifer C Darnell; Robert B Darnell
A mouse model of the human Fragile X syndrome I304N mutation.
PLoS genetics 2009;5(12):e1000758.
2009: Kiran Musunuru; Marju Orho-Melander; Michael P Caulfield; Shuguang Li; Wael A Salameh; Richard E Reitz; Göran Berglund; Bo Hedblad; Gunnar Engström; Paul T Williams; Sekar Kathiresan; Olle Melander; Ronald M Krauss
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1975-80.
2009: Kavita Sharma; Michael J Blaha; Roger S Blumenthal; Kiran Musunuru
Clinical and research applications of carotid intima-media thickness.
The American journal of cardiology 2009;103(9):1316-20.
2009: Samia Mora; Kiran Musunuru; Roger S Blumenthal
The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelines.
Clinical chemistry 2009;55(2):219-28.
2008: Kiran Musunuru; Santosh kesari
Paraneoplastic opsoclonus-myoclonus ataxia associated with non-small-cell lung carcinoma.
Journal of neuro-oncology 2008;90(2):213-6.
2008: Kiran Musunuru; Sekar Kathiresan
HapMap and mapping genes for cardiovascular disease.
Circulation. Cardiovascular genetics 2008;1(1):66-71.
2008: Kiran Musunuru; Brian G Kral; Roger S Blumenthal; Valentin Fuster; Catherine Y Campbell; Ty J Gluckman; Richard A Lange; Eric J Topol; James T Willerson; Milind Y Desai; Michael H Davidson; Samia Mora
The use of high-sensitivity assays for C-reactive protein in clinical practice.
Nature clinical practice. Cardiovascular medicine 2008;5(10):621-35.
2008: Kiran Musunuru; Khurram Nasir; Shivda Pandey; Catherine C Campbell; Jose A M Carvalho; Romeu Meneghello; Matthew J Budoff; Roger S Blumenthal; Raul Santos
A synergistic relationship of elevated low-density lipoprotein cholesterol levels and systolic blood pressure with coronary artery calcification.
Atherosclerosis 2008;200(2):368-73.
2008: Kiran Musunuru; Roger S Blumenthal
The implications of the ezetimibe and simvastatin in hypercholesterolemia enhances atherosclerosis regression trial: a return to first principles.
Clinical cardiology 2008;31(6):288-90.
2008: Sekar Kathiresan; Kiran Musunuru; Marju Orho-Melander
Defining the spectrum of alleles that contribute to blood lipid concentrations in humans.
Current opinion in lipidology 2008;19(2):122-7.
2008: Raza H Orakzai; Khurram Nasir; Sarwar H Orakzai; Nove Kalia; Ambarish Gopal; Kiran Musunuru; Roger S Blumenthal; Matthew J Budoff
Effect of patient visualization of coronary calcium by electron beam computed tomography on changes in beneficial lifestyle behaviors.
The American journal of cardiology 2008;101(7):999-1002.
2008: Navin K Kapur; Kiran Musunuru
Clinical efficacy and safety of statins in managing cardiovascular risk.
Vascular health and risk management 2008;4(2):341-53.
2007: Kiran Musunuru; Roger S Blumenthal
Biomarkers for prediction of cardiovascular events.
The New England journal of medicine 2007;356(14):1472; author reply 1474-5.
2004: Kiran Musunuru; Robert B Darnell
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains.
Nucleic acids research 2004;32(16):4852-61.
2003: Virany Huynh Hillard; Kiran Musunuru; Izhar Hasan; S Zia; Alan Hirschfeld
Long-term management of bilateral metastases of renal cell carcinoma to the choroid plexus.
Acta neurochirurgica 2003;145(9):793-7.
2003: Kiran Musunuru; Virany Huynh Hillard; Raj Murali
Widespread central nervous system cavernous malformations associated with café-au-lait skin lesions. Case report.
Journal of neurosurgery 2003;99(2):412-5.
2003: Kiran Musunuru
Cell-specific RNA-binding proteins in human disease.
Trends in cardiovascular medicine 2003;13(5):188-95.
2003: Kim L Farina; Stefan Huttelmaier; Kiran Musunuru; Robert Darnell; Robert H Singer
Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment.
The Journal of cell biology 2003;160(1):77-87.
2002: Virany Huynh Hillard; Kiran Musunuru; Chiedozie Nwagwu; Kaushik Das; Raj Murali; Bruce Zablow; Alan Hirschfeld
Treatment of an anterior communicating artery aneurysm through an anomalous anastomosis from the cavernous internal carotid artery.
Journal of neurosurgery 2002;97(6):1432-5.
2001: Kiran Musunuru; Robert B Darnell
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration.
Annual review of neuroscience 2001;24():239-62.
2000: Kirk B Jensen; Kiran Musunuru; Hal A Lewis; Stephen K Burley; Robert B Darnell
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5740-5.
2000: Hal A Lewis; Kiran Musunuru; Kirk B Jensen; C Edo; H Chen; Robert B Darnell; Stephen K Burley
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.
Cell 2000;100(3):323-32.
1999: Hal A Lewis; H Chen; C Edo; Ronald J Buckanovich; YY Yang; Kiran Musunuru; R Zhong; Robert B Darnell; Stephen K Burley
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.
Structure (London, England : 1993) 1999;7(2):191-203.