Ernst Mutschler

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Knauf H; Bailey M A; Hasenfuss G; Mutschler E
The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects.
Knauf Heinrich; Mutschler Ernst
[Sequential nephron blockade]
Knauf Heinrich; Mutschler Ernst
[Pharmacology of diuretics]

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All Publications

2006: Knauf H; Bailey M A; Hasenfuss G; Mutschler E
The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects.
European journal of clinical pharmacology 2006;62(11):885-92.
2006: Knauf Heinrich; Mutschler Ernst
[Sequential nephron blockade]
Pharmazie in unserer Zeit 2006;35(4):334-40.
2006: Knauf Heinrich; Mutschler Ernst
[Pharmacology of diuretics]
Pharmazie in unserer Zeit 2006;35(4):302-9.
2005: Fuhr U; Kober S; Zaigler M; Mutschler E; Spahn-Langguth H
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
International journal of clinical pharmacology and therapeutics 2005;43(7):327-34.
2005: Knauf Heinrich; Mutschler Ernst
[Mechanism of action of xipamide and its classification as a "low ceiling diuretic". Pharmacodynamic-pharmacokinetic studies in healthy volunteers and in kidney and liver patients]
Arzneimittel-Forschung 2005;55(1):1-14.
2003: Böhme Thomas M; Keim Christine; Kreutzmann Kai; Linder Matthias; Dingermann Theo; Dannhardt Gerd; Mutschler Ernst; Lambrecht Günter
Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.
Journal of medicinal chemistry 2003;46(5):856-67.
2002: Belz Gustav G; Butzer Raunhild; Kober Susan; Mutschler Ernst
Pharmacodynamic studies on the angiotensin II type 1 antagonists irbesartan and candesartan based on angiotensin II dose response in humans.
Journal of cardiovascular pharmacology 2002;39(4):561-8.
2002: Horstkötter Christian; Kober Susan; Spahn-Langguth Hildegard; Mutschler Ernst; Blaschke Gottfried
Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;769(1):107-17.
2001: Böhme T M; Keim C; Dannhardt G; Mutschler E; Lambrecht G
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.
Bioorganic & medicinal chemistry letters 2001;11(9):1241-3.
2000: Fuchs B; Breithaupt-Grögler K; Belz G G; Roll S; Malerczyk C; Herrmann V; Spahn-Langguth H; Mutschler E
Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man.
The Journal of pharmacy and pharmacology 2000;52(9):1075-83.
2000: Lambrecht G; Ganso M; Bäumert H G; Spatz-Kümbel G; Hildebrandt C; Braun K; Mutschler E
The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y(1) receptor-mediated responses.
Journal of the autonomic nervous system 2000;81(1-3):171-7.
2000: Hermening A; Gräfe A K; Baktir G; Mutschler E; Spahn-Langguth H
Gemfibrozil and its oxidative metabolites: quantification of aglycones, acyl glucuronides, and covalent adducts in samples from preclinical and clinical kinetic studies.
Journal of chromatography. B, Biomedical sciences and applications 2000;741(2):129-44.
2000: Soldner A; Benet L Z; Mutschler E; Christians U
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
British journal of pharmacology 2000;129(6):1235-43.
2000: Tumiatti V; Wehrle J; Hildebrandt C; Moser U; Dannhardt G; Mutschler E; Lambrecht G
Muscarinic properties of compounds related to arecaidine propargyl ester.
Arzneimittel-Forschung 2000;50(1):11-5.
2000: Lambrecht G; Rettinger J; Bäumert H G; Czeche S; Damer S; Ganso M; Hildebrandt C; Niebel B; Spatz-Kümbel G; Schmalzing G; Mutschler E
The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X(1) receptors.
European journal of pharmacology 2000;387(3):R19-21.
1999: Belz G G; Butzer R; Kober S; Mang C; Mutschler E
Time course and extent of angiotensin II antagonism after irbesartan, losartan, and valsartan in humans assessed by angiotensin II dose response and radioligand receptor assay.
Clinical pharmacology and therapeutics 1999;66(4):367-73.
1999: Nicke A; Rettinger J; Mutschler E; Schmalzing G
Blue native PAGE as a useful method for the analysis of the assembly of distinct combinations of nicotinic acetylcholine receptor subunits.
Journal of receptor and signal transduction research 1999;19(1-4):493-507.
1999: Lambrecht G; Damer S; Niebel B; Czeche S; Nickel P; Rettinger J; Schmalzing G; Mutschler E
Novel ligands for P2 receptor subtypes in innervated tissues.
Progress in brain research 1999;120():107-17.
1999: Mutschler E; Knauf H
Current status of sustained release formulations in the treatment of hypertension. An overview.
Clinical pharmacokinetics 1999;37 Suppl 1():1-6.
1999: Lambrecht G; Gross J; Mutschler E
Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle.
Life sciences 1999;64(6-7):403-10.
1998: Malerczyk C; Fuchs B; Belz G G; Roll S; Butzer R; Breithaupt-Grögler K; Herrmann V; Magin S G; Högemann A; Voith B; Mutschler E
Angiotensin II antagonism and plasma radioreceptor-kinetics of candesartan in man.
British journal of clinical pharmacology 1998;45(6):567-73.
1998: Nicke A; Bäumert H G; Rettinger J; Eichele A; Lambrecht G; Mutschler E; Schmalzing G
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.
The EMBO journal 1998;17(11):3016-28.
1998: Damer S; Niebel B; Czeche S; Nickel P; Ardanuy U; Schmalzing G; Rettinger J; Mutschler E; Lambrecht G
NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
European journal of pharmacology 1998;350(1):R5-6.
1998: Soldner A; Spahn-Langguth H; Palm D; Mutschler E
A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites.
Journal of pharmaceutical and biomedical analysis 1998;17(1):111-24.
1998: Soldner A; Spahn-Langguth H; Mutschler E
HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats.
Journal of pharmaceutical and biomedical analysis 1998;16(5):863-73.
1998: Knauf H; Mutschler E
Clinical pharmacokinetics and pharmacodynamics of torasemide.
Clinical pharmacokinetics 1998;34(1):1-24.
1997: Weiser M; Mutschler E; Lambrecht G
Characterization of postjunctional muscarinic receptors mediating contraction in rat anococcygeus muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(5):671-7.
1997: Möhrke W; Knauf H; Mutschler E
Pharmacokinetics and pharmacodynamics of triamterene and hydrochlorothiazide and their combination in healthy volunteers.
International journal of clinical pharmacology and therapeutics 1997;35(10):447-52.
1997: Gross J; Mutschler E; Lambrecht G
Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(4):505-16.
1997: Belz G G; Fuchs B; Malerczyk C; Magin S G; Roll S; Mutschler E
Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers.
Journal of human hypertension 1997;11 Suppl 2():S45-7.
1997: Langer K; Lambrecht G; Moser U; Mutschler E; Kreuter J
Quantitative colorimetric and gas chromatographic determination of arecaidine propargyl ester.
Journal of chromatography. B, Biomedical sciences and applications 1997;692(2):345-50.
1997: Ziyal R; Ziganshin A U; Nickel P; Ardanuy U; Mutschler E; Lambrecht G; Burnstock G
Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery.
British journal of pharmacology 1997;120(5):954-60.
1997: Knauf H; Mutschler E
Sequential nephron blockade breaks resistance to diuretics in edematous states.
Journal of cardiovascular pharmacology 1997;29(3):367-72.
1996: Waelbroeck M; Lazareno S; Pfaff O; Friebe T; Tastenoy M; Mutschler E; Lambrecht G
Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes.
British journal of pharmacology 1996;119(7):1319-30.
1996: Soldner A; Spahn-Langguth H; Mutschler E
The renin-angiotensin-aldosterone system: focus on its distinct role in arterial hypertension and its various inhibitors as a therapeutic strategy to effectively lower blood pressure.
Die Pharmazie 1996;51(11):783-99.
1996: Büschges R; Devant R; Mutschler E; Spahn-Langguth H
4-(6-methoxy-2-naphthyl)-2-butyl chloroformate enantiomers: new reagents for the enantiospecific analysis of amino compounds in biogenic matrices.
Journal of pharmaceutical and biomedical analysis 1996;15(2):201-20.
1996: Olbrich H G; Grabisch P; Grossmann A; Rinne T; Klepzig H; Mutschler E
Protective action of hydroxyethyl rutosides on singlet oxygen challenged cardiomyocytes.
British journal of pharmacology 1996;119(4):671-6.
1996: Waelbroeck M; Hou X; Wehrle J; Mutschler E; Van Tilburg E; Menge W; Timmerman H; Lambrecht G
Stereoselective interaction of uncharged esters at four muscarinic receptor subtypes.
European journal of pharmacology 1996;303(3):221-6.
1996: Wetterich U; Spahn-Langguth H; Mutschler E; Terhaag B; Rösch W; Langguth P
Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.
Pharmaceutical research 1996;13(4):514-22.
1996: Priewer H; Ullrich F; Mutschler E
Potassium and magnesium retaining potency and efficacy of triamterene and analogues in conscious saline-loaded rats.
Magnesium research : official organ of the International Society for the Development of Research on Magnesium 1996;9(1):33-40.
1996: Hanses A; Spahn-Langguth H; Meiss F; Mutschler E
Pharmacokinetics and drug input characteristics for a diclofenac-codeine phosphate combination following oral and rectal administration.
Arzneimittel-Forschung 1996;46(1):57-63.
1995: de Mey C; Schroeter V; Butzer R; Jahn P; Weisser K; Wetterich U; Terhaag B; Mutschler E; Spahn-Langguth H; Palm D
Dose-effect and kinetic-dynamic relationships of the beta-adrenoceptor blocking properties of various doses of talinolol in healthy humans.
Journal of cardiovascular pharmacology 1995;26(6):879-8.
1995: Pfaff O; Hildebrandt C; Waelbroeck M; Hou X; Moser U; Mutschler E; Lambrecht G
The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist.
European journal of pharmacology 1995;286(3):229-40.
1995: Voith B; Spahn-Langguth H; Mutschler E
New specific and sensitive HPLC-assays for ethacrynic acid and its main metabolite--the cysteine conjugate--in biological material.
Journal of pharmaceutical and biomedical analysis 1995;13(11):1373-82.
1995: Windscheif U; Radziwon P; Breddin H K; Bäumert H G; Lambrecht G; Mutschler E
Two different inhibitory effects of pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid on adenosine diphosphate-induced human platelet aggregation.
Arzneimittel-Forschung 1995;45(9):994-7.
1995: Windscheif U; Pfaff O; Ziganshin A U; Hoyle C H; Bäumert H G; Mutschler E; Burnstock G; Lambrecht G
Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum.
British journal of pharmacology 1995;115(8):1509-17.
1995: Priewer H; Wolf E; Ullrich F; Netzer T; Vollmer G; Mutschler E
Investigations on the acute toxicity of acidic and basic triamterene derivatives.
Die Pharmazie 1995;50(6):419-21.
1995: Jahn P; Eckrich B; Schneidrowski B; Volz-Zang C; Schulte B; Mutschler E; Palm D
Beta 1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man. Investigations using tricresylphosphate as red blood cell carboxylesterase inhibitor.
Arzneimittel-Forschung 1995;45(5):536-41.
1995: Hanses A; Spahn-Langguth H; Mutschler E
A new rapid and sensitive high-performance liquid chromatographic assay for diclofenac in human plasma.
Archiv der Pharmazie 1995;328(3):257-60.
1995: Mutschler E; Moser U; Wess J; Lambrecht G
Muscarinic receptor subtypes--pharmacological, molecular biological and therapeutical aspects.
Pharmaceutica acta Helvetiae 1995;69(4):243-58.
1995: Wetterich U; Mutschler E
Quality of cefotaxime sodium preparations.
Arzneimittel-Forschung 1995;45(1):74-80.
1994: Windscheif U; Ralevic V; Bäumert H G; Mutschler E; Lambrecht G; Burnstock G
Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x-purinoceptors.
British journal of pharmacology 1994;113(3):1015-21.
1994: Zimmer A; Mutschler E; Lambrecht G; Mayer D; Kreuter J
Pharmacokinetic and pharmacodynamic aspects of an ophthalmic pilocarpine nanoparticle-delivery-system.
Pharmaceutical research 1994;11(10):1435-42.
1994: Grimm U; Moser U; Mutschler E; Lambrecht G
Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists.
Die Pharmazie 1994;49(10):711-26.
1994: Waelbroeck M; Camus J; Tastenoy M; Feifel R; Mutschler E; Tacke R; Strohmann C; Rafeiner K; Rodrigues de Miranda J F; Lambrecht G
Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes.
British journal of pharmacology 1994;112(2):505-14.
1994: Gido C; Langguth P; Mutschler E
Predictions of in vivo plasma concentrations from in vitro release kinetics: application to doxepin parenteral (i.m.) suspensions in lipophilic vehicles in dogs.
Pharmaceutical research 1994;11(6):800-8.
1994: Neubeck M; Henke D; Spahn-Langguth H; Mutschler E
Simultaneous determination of (R)- and (S)-brefanolol in human plasma: high-performance liquid chromatographic assay on a chiral stationary phase.
Archiv der Pharmazie 1994;327(3):193-6.
1994: Ziganshin A U; Hoyle C H; Lambrecht G; Mutschler E; Bümert H G; Burnstock G
Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels.
British journal of pharmacology 1994;111(3):923-9.
1994: Grimm U; Fuder H; Moser U; Bümert H G; Mutschler E; Lambrecht G
Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(1):1-10.
1994: Neubeck M; Fliser D; Pritsch M; Weisser K; Fliser M; Nussberger J; Ritz E; Mutschler E
Pharmacokinetics and pharmacodynamics of lisinopril in advanced renal failure. Consequence of dose adjustment.
European journal of clinical pharmacology 1994;46(6):537-43.
1994: Ding R W; Port R E; Ortmann K; Liebmann B; Spahn-Langguth H; Mutschler E; Weber E
The effect of ciclotropium on human heart rate.
European journal of clinical pharmacology 1994;46(5):455-9.
1993: Ziganshin A U; Hoyle C H; Bo X; Lambrecht G; Mutschler E; Bäumert H G; Burnstock G
PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder.
British journal of pharmacology 1993;110(4):1491-5.
1993: Weber-Grandke H; Hahn G; Mutschler E; Möhrke W; Langguth P; Spahn-Langguth H
The pharmacokinetics of tranylcypromine enantiomers in healthy subjects after oral administration of racemic drug and the single enantiomers.
British journal of clinical pharmacology 1993;36(4):363-5.
1993: Spahn-Langguth H; Möhrke W; Mutschler E; Platt D
[Pharmacokinetics and -dynamics of calcium antagonists in the elderly]
Fortschritte der Medizin 1993;111(28):441-5.
1993: Gido C; Langguth P; Kreuter J; Winter G; Woog H; Mutschler E
Conventional versus novel conditions for the in vitro dissolution testing of parenteral slow release formulations: application to doxepin parenteral dosage forms.
Die Pharmazie 1993;48(10):764-9.
1993: Neubeck M; Becker C; Henke D; Rösch W; Spahn-Langguth H; Mutschler E
Pharmacokinetics of dilevalol and its conjugates in man. Assay method for plasma, blood, urine and bile samples and preliminary pharmacokinetic studies.
Arzneimittel-Forschung 1993;43(9):953-7.
1993: Stahl E; Mutschler E; Baumgartner U; Spahn-Langguth H
Carvedilol stereopharmacokinetics in rats: affinities to blood constituents and tissues.
Archiv der Pharmazie 1993;326(9):529-33.
1993: Witte K; Weisser K; Neubeck M; Mutschler E; Lehmann K; Hopf R; Lemmer B
Cardiovascular effects, pharmacokinetics, and converting enzyme inhibition of enalapril after morning versus evening administration.
Clinical pharmacology and therapeutics 1993;54(2):177-86.
1993: Eltze M; Ullrich B; Mutschler E; Moser U; Bungardt E; Friebe T; Gubitz C; Tacke R; Lambrecht G
Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney.
European journal of pharmacology 1993;238(2-3):343-55.
1993: Waelbroeck M; Camus J; Tastenoy M; Lambrecht G; Mutschler E; Kropfgans M; Sperlich J; Wiesenberger F; Tacke R; Christophe J
Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type.
British journal of pharmacology 1993;109(2):360-70.
1993: Stahl E; Henke D; Mutschler E; Spahn-Langguth H
Saturable enantioselective first-pass effect for carvedilol after high oral racemate doses in rats.
Archiv der Pharmazie 1993;326(3):123-5.
1993: Mayer S; Spahn-Langguth H; Gikalov I; Mutschler E
Pharmacokinetics of beclobric acid enantiomers and their conjugates after single and multiple oral dosage of racemic beclobrate.
Arzneimittel-Forschung 1993;43(1):40-3.
1993: Kofahl B; Henke D; Hettenbach A; Mutschler E
Studies on placental transfer of celiprolol.
European journal of clinical pharmacology 1993;44(4):381-2.
1993: Kofahl B; Henke D; Mutschler E
Direct enantiospecific HPLC bioanalysis of (R,S)-atenolol on a chiral stationary phase.
Chirality 1993;5(6):479-82.
1993: Mayer S; Mutschler E; Benet L Z; Sphahn-Langguth H
In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers.
Chirality 1993;5(3):120-5.
1993: Stahl E; Baumgartner U; Henke D; Schölmerich J; Mutschler E; Spahn-Langguth H
Rats with portacaval shunt as a potential experimental pharmacokinetic model for liver cirrhosis: application to carvedilol stereopharmacokinetics.
Chirality 1993;5(1):1-7.
1993: Lambrecht G; Moser U; Grimm U; Pfaff O; Hermanni U; Hildebrandt C; Waelbroeck M; Christophe J; Mutschler E
New functionally selective muscarinic agonists.
Life sciences 1993;52(5-6):481-8.
1992: Russ T; Ried W; Ullrich F; Mutschler E
Preparation and diuretic properties of novel amiloride analogues.
Archiv der Pharmazie 1992;325(12):761-7.
1992: Netzer T; Knauf H; Mutschler E
Modulation of electrolyte excretion by potassium retaining diuretics.
European heart journal 1992;13 Suppl G():22-7.
1992: Rauwald H W; Kober M; Mutschler E; Lambrecht G
Cryptolepis sanguinolenta: antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors.
Planta medica 1992;58(6):486-8.
1992: Spahn-Langguth H; Hahn G; Mutschler E; Möhrke W; Langguth P
Enantiospecific high-performance liquid chromatographic assay with fluorescence detection for the monoamine oxidase inhibitor tranylcypromine and its applicability in pharmacokinetic studies.
Journal of chromatography 1992;584(2):229-37.
1992: Liebmann B; Mayer S; Mutschler E; Spahn-Langguth H
Studies on the metabolic clearance of ciclotropium to alpha-phenylciclopentylacetic acid using a new enantiospecific metabolite assay.
Arzneimittel-Forschung 1992;42(11):1354-8.
1992: Bungardt E; Buschauer A; Moser U; Schunack W; Lambrecht G; Mutschler E
Histamine H1 receptors mediate vasodilation in guinea-pig ileum resistance vessels: characterization with computer-assisted videomicroscopy and new selective agonists.
European journal of pharmacology 1992;221(1):91-8.
1992: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Schjelderup L; Aasen A; Lambrecht G; Christophe J
Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology 1992;227(1):33-42.
1992: Horne C; Stenzhorn G; Blume H; Knauf H; Mutschler E
Bioavailability study of two different verapamil formulations.
Archiv der Pharmazie 1992;325(8):531-6.
1992: Lambrecht G; Friebe T; Grimm U; Windscheif U; Bungardt E; Hildebrandt C; Bäumert H G; Spatz-Kümbel G; Mutschler E
PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.
European journal of pharmacology 1992;217(2-3):217-9.
1992: Schuchmann H W; Rösch W; Koch U; Maurer H H; Stengl U; Mutschler E
Pharmacokinetics of azosemide in patients with T-drain after cholecystectomy.
Arzneimittel-Forschung 1992;42(6):812-4.
1992: Netzer T; Ullrich F; Majewski M; Mutschler E
Synthesis, natriuretic, antikaliuretic and antimagnesiuretic properties of an acidic triamterene derivative.
Arzneimittel-Forschung 1992;42(6):807-11.
1992: Netzer T; Ullrich F; Priewer H; Majewski M; Mutschler E
Effects of a new pteridine derivative on urinary sodium, potassium and magnesium excretion in conscious saline-loaded rats.
British journal of pharmacology 1992;106(1):222-6.
1992: Bungardt E; Vockert E; Feifel R; Moser U; Tacke R; Mutschler E; Lambrecht G; Surprenant A
Characterization of muscarinic receptors mediating vasodilation in guinea-pig ileum submucosal arterioles by the use of computer-assisted videomicroscopy.
European journal of pharmacology 1992;213(1):53-61.
1992: Olbrich H G; Boeker J F; Rachor S; Ketelsen U P; Wieland H; Kober G; Schmidt A; Mutschler E
Effect of magnesium pyridoxal 5-phosphate glutamate on the hamster cardiomyopathy.
Arzneimittel-Forschung 1992;42(3):292-6.
1992: Eltze M; Mutschler E; Lambrecht G
Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3.
European journal of pharmacology 1992;211(3):283-93.
1992: Weisser K; Schloos J; Jakob S; Mühlberg W; Platt D; Mutschler E
The influence of hydrochlorothiazide on the pharmacokinetics of enalapril in elderly patients.
European journal of clinical pharmacology 1992;43(2):173-7.
1991: Liebmann B; Henke D; Spahn-Langguth H; Mutschler E
Determination of the quaternary compound ciclotropium in human biological material after hydrolysis and derivatization with the fluorophor flunoxaprofen chloride.
Journal of chromatography 1991;572(1-2):181-93.
1991: Busch A E; Ullrich F; Mutschler E
Antiarrhythmic properties of triamterene derivatives in the coronary artery ligated rat model.
Archiv der Pharmazie 1991;324(11):895-8.
1991: Spahn-Langguth H; Podkowik B; Stahl E; Martin E; Mutschler E
Improved enantiospecific RP-HPLC assays for propranolol in plasma and urine with pronethalol as internal standard.
Journal of analytical toxicology 1991;15(6):327-31.
1991: Schulte B; Volz-Zang C; Mutschler E; Horne C; Palm D; Wellstein A; Pitschner H F
AF-DX 116, a cardioselective muscarinic antagonist in humans: pharmacodynamic and pharmacokinetic properties.
Clinical pharmacology and therapeutics 1991;50(4):372-8.
1991: Dörje F; Rettenmayr N M; Mutschler E; Lambrecht G
Effect of extracellular calcium concentration on potency of muscarinic agonists at M1 and M2 receptors in rabbit vas deferens.
European journal of pharmacology 1991;203(3):417-20.
1991: Spahn-Langguth H; Hahn G; Mutschler E
Rapid assay for the quantification of piretanide in biological fluids.
Archiv der Pharmazie 1991;324(7):445-7.
1991: Spahn-Langguth H; Podkowik B; Stahl E; Martin E; Mutschler E
Improved enantiospecific RP-HPLC assays for propranolol in plasma and urine with pronethalol as internal standard.
Journal of analytical toxicology 1991;15(4):209-13.
1991: Feifel R; Rodrigues de Miranda J F; Strohmann C; Tacke R; Aasen A J; Mutschler E; Lambrecht G
Selective labelling of muscarinic M1 receptors in calf superior cervical ganglia by [3H](+/-)-telenzepine.
European journal of pharmacology 1991;195(1):115-23.
1991: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects.
European journal of pharmacology 1991;206(2):95-103.
1991: Busch A E; Netzer T; Ullrich F; Mutschler E
Antiarrhythmic properties of benzyl-triamterene derivatives in the coronary artery ligated and reperfused rat.
Arzneimittel-Forschung 1991;41(2):125-7.
1991: Dörje F; Wess J; Lambrecht G; Tacke R; Mutschler E; Brann M R
Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1991;256(2):727-33.
1991: Wess J; Lambrecht G; Mutschler E; Brann M R; Dörje F
Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations.
British journal of pharmacology 1991;102(1):246-50.
1991: Busch A E; Ullrich F; Mutschler E
In vitro testing of triamterene derivatives for antiarrhythmic activity.
Archiv der Pharmazie 1991;324(1):39-44.
1991: Mayer S; Mutschler E; Spahn-Langguth H
Pharmacokinetic studies with the lipid-regulating agent beclobrate: enantiospecific assay for beclobric acid using a new fluorescent chiral coupling component (S-FLOPA).
Chirality 1991;3(1):35-42.
1991: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors.
Chirality 1991;3(2):118-23.
1991: Weisser K; Schloos J; Lehmann K; Düsing R; Vetter H; Mutschler E
Pharmacokinetics and converting enzyme inhibition after morning and evening administration of oral enalapril to healthy subjects.
European journal of clinical pharmacology 1991;40(1):95-9.
1990: Dörje F; Friebe T; Tacke R; Mutschler E; Lambrecht G
Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(3):284-9.
1990: Waelbroeck M; Camus J; Tastenoy M; Lambrecht G; Mutschler E; Tacke R; Christophe J
Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4.
European journal of pharmacology 1990;189(2-3):135-42.
1990: Rettenmayr N M; Rodrigues de Miranda J F; Rijntjes N V; Russel F G; van Ginneken C A; Strohmann C; Tacke R; Lambrecht G; Mutschler E
Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(2):146-52.
1990: Spahn H; Henke W; Langguth P; Schloos J; Mutschler E
Measurement of carvedilol enantiomers in human plasma and urine using S-naproxen chloride for chiral derivatization.
Archiv der Pharmazie 1990;323(8):465-9.
1990: Feifel R; Wagner-Röder M; Strohmann C; Tacke R; Waelbroeck M; Christophe J; Mutschler E; Lambrecht G
Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro-difenidol and acetylenic analogues.
British journal of pharmacology 1990;99(3):455-60.
1990: Warlich R; Korting H C; Schäfer-Korting M; Mutschler E
Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers.
Antimicrobial agents and chemotherapy 1990;34(1):78-81.
1990: Gietl Y; Spahn H; Knauf H; Mutschler E
Single- and multiple-dose pharmacokinetics of R-(-)-and S-(+)-prenylamine in man.
European journal of clinical pharmacology 1990;38(6):587-93.
1990: Mutschler E; Knauf H; Möhrke W; Völger K D
[Diuretic therapy in the aged]
Verhandlungen der Deutschen Gesellschaft für Innere Medizin 1990;96():265-73.
1990: Spahn H; Knauf H; Mutschler E
Pharmacokinetics of torasemide and its metabolites in healthy controls and in chronic renal failure.
European journal of clinical pharmacology 1990;39(4):345-8.
1990: Hartmann C; Frölich M; Krauss D; Spahn-Langguth H; Knauf H; Mutschler E
Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function.
European journal of clinical pharmacology 1990;39(6):573-6.
1989: Waelbroeck M; Tastenoy M; Camus J; Feifel R; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Stereoselectivity of the interaction of muscarinic antagonists with their receptors.
Trends in pharmacological sciences 1989;Suppl():65-9.
1989: Eltze M; Lambrecht G; Mutschler E
Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes.
European journal of pharmacology 1989;173(2-3):219-22.
1989: Bräunig B; Busch A E; Mutschler E; Wess J; Oelschläger H
Antiarrhythmic activity of the local anaesthetic fomocaine and some of its analogues.
Arzneimittel-Forschung 1989;39(11):1436-9.
1989: Eltze M; Boer R; Mutschler E; Lambrecht G
Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors.
European journal of pharmacology 1989;170(3):225-34.
1989: Hartmann C; Krauss D; Spahn H; Mutschler E
Simultaneous determination of (R)- and (S)-celiprolol in human plasma and urine: high-performance liquid chromatographic assay on a chiral stationary phase with fluorimetric detection.
Journal of chromatography 1989;496(2):387-96.
1989: Waelbroeck M; Tastenoy M; Camus J; Christophe J; Strohmann C; Linoh H; Zilch H; Tacke R; Mutschler E; Lambrecht G
Binding and functional properties of antimuscarinics of the hexocyclium/sila-hexocyclium and hexahydro-diphenidol/hexahydro-sila-diphenidol type to muscarinic receptor subtypes.
British journal of pharmacology 1989;98(1):197-205.
1989: Lambrecht G; Feifel R; Wagner-Röder M; Strohmann C; Zilch H; Tacke R; Waelbroeck M; Christophe J; Boddeke H; Mutschler E
Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes.
European journal of pharmacology 1989;168(1):71-80.
1989: Gietl Y; Spahn H; Mutschler E
Enantioselective disposition of R-(-)- and S-(+)-prenylamine in the rat.
Arzneimittel-Forschung 1989;39(8):853-6.
1989: Warlich R; Krauss D; Mutschler E
Fluorimetric determination of norfloxacin in plasma and urine samples after thin-layer chromatographic separation.
Arzneimittel-Forschung 1989;39(6):656-8.
1989: Warlich R; Mutschler E
Thin-layer chromatographic separation and in situ fluorimetric determination of ofloxacin in plasma and pleural fluid.
Journal of chromatography 1989;490(2):395-403.
1989: Wolf-Pflugmann M; Lambrecht G; Wess J; Mutschler E
Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester.
Arzneimittel-Forschung 1989;39(5):539-44.
1989: Moser U; Lambrecht G; Wagner M; Wess J; Mutschler E
Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes.
British journal of pharmacology 1989;96(2):319-24.
1989: Spahn H; Wellstein A; Pflugmann G; Mutschler E; Palm D
Radioreceptor assay of metoprolol in human plasma: comparison with an enantiospecific high-performance liquid chromatographic (HPLC) procedure.
Pharmaceutical research 1989;6(2):152-5.
1989: Martin E; Quinke K; Spahn H; Mutschler E
(-)-(S)-flunoxaprofen and (-)-(S)-naproxen isocyanate: two new fluorescent chiral derivatizing agents for an enantiospecific determination of primary and secondary amines.
Chirality 1989;1(3):223-34.
1989: Lambrecht G; Feifel R; Mutschler E
Stereoselectivity at muscarinic receptor subtypes: observations with the enantiomers of phenglutarimide.
Chirality 1989;1(2):170-3.
1988: Spahn H; Spahn I; Pflugmann G; Mutschler E; Benet L Z
Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component.
Journal of chromatography 1988;433():331-8.
1988: Eltz M; Gmelin G; Wess J; Strohmann C; Tacke R; Mutschler E; Lambrecht G
Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type.
European journal of pharmacology 1988;158(3):233-42.
1988: Lambrecht G; Feifel R; Moser U; Aasen A J; Waelbroeck M; Christophe J; Mutschler E
Stereoselectivity of the enantiomers of trihexyphenidyl and its methiodide at muscarinic receptor subtypes.
European journal of pharmacology 1988;155(1-2):167-70.
1988: Krauss D; Spahn H; Mutschler E
Quantification of baclofen and its fluoro analogue in plasma and urine after fluorescent derivatisation with benoxaprofen chloride and thin-layer chromatographic separation.
Arzneimittel-Forschung 1988;38(10):1533-6.
1988: Wess J; Angeli P; Melchiorre C; Moser U; Mutschler E; Lambrecht G
Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(3):246-9.
1988: Lambrecht G; Feifel R; Forth B; Strohmann C; Tacke R; Mutschler E
p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist.
European journal of pharmacology 1988;152(1-2):193-4.
1988: Lambrecht G; Gmelin G; Rafeiner K; Strohmann C; Tacke R; Mutschler E
o-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist.
European journal of pharmacology 1988;151(1):155-6.
1988: Gietl Y; Spahn H; Mutschler E
Simultaneous determination of R- and S-prenylamine in plasma and urine by reversed-phase high-performance liquid chromatography.
Journal of chromatography 1988;426(2):304-14.
1988: Spahn H; Krauss D; Mutschler E
Enantiospecific high-performance liquid chromatographic (HPLC) determination of baclofen and its fluoro analogue in biological material.
Pharmaceutical research 1988;5(2):107-12.
1988: Simrock R; Rehders K; Spahn H; Mutschler E; Breddin H K
Plasma drug and antiplatelet profiles of the original acetylsalicylic acid preparations used in the AMIS, PARIS and German-Austrian trials for secondary prevention of myocardial infarction.
European journal of clinical pharmacology 1988;33(6):541-7.
1987: Schäfer-Korting M; Belz G G; Brauer J; Alken R G; Mutschler E
Digoxin concentrations in serum and cantharides blister fluid: correlations with cardiac response.
Clinical pharmacology and therapeutics 1987;42(6):613-20.
1987: Trenk D; Wagner F; Jähnchen E; Spahn H; Mutschler E
Pharmacokinetics and bioavailability of piretanide in healthy volunteers following intramuscular administration.
Arzneimittel-Forschung 1987;37(12):1382-5.
1987: Langguth P; Mutschler E
Lipophilisation of hydrophilic compounds. Consequences on transepidermal and intestinal transport of trospium chloride.
Arzneimittel-Forschung 1987;37(12):1362-6.
1987: Horne C; Spahn H; Mutschler E
Fluorimetric determination of levoprotiline in human plasma after thin-layer chromatographic or high performance liquid chromatographic separation.
Arzneimittel-Forschung 1987;37(10):1179-81.
1987: Pflugmann G; Spahn H; Mutschler E
Determination of metoprolol enantiomers in plasma and urine using (S)-(-)-phenylethyl isocyanate as a chiral reagent.
Journal of chromatography 1987;421(1):161-4.
1987: Wess J; Lambrecht G; Mutschler E; Melchiorre C; Angeli P
Selective blockade in vivo of cardiac muscarinic M2 receptors by a polymethylene tetramine, BHC-9C.
European journal of pharmacology 1987;142(3):475-8.
1987: Horne C; Spahn H; Mutschler E; Knauf H
Determination of verapamil and norverapamil in human biological material. Investigation of plasma concentrations after oral administration of two different verapamil formulations.
Arzneimittel-Forschung 1987;37(8):956-9.
1987: Buhl T; Rodrigues de Miranda J F; Beld A J; Lambrecht G; Mutschler E
Binding of the S(+)- and R(-)-enantiomers of bethanechol to muscarinic receptors in jejunal smooth muscle, nasal mucosa, atrial and ventricular myocardium of the rat.
European journal of pharmacology 1987;140(2):221-6.
1987: Pflugmann G; Spahn H; Mutschler E
Rapid determination of the enantiomers of metoprolol, oxprenolol and propranolol in urine.
Journal of chromatography 1987;416(2):331-9.
1987: Priewer H; Wolf E; Kraft H; Knauf H; Mutschler E
Dissociation of the natriuretic and antikaliuretic properties of triamterene derivatives by dose-response experiments.
Pharmaceutical research 1987;4(1):66-9.
1987: Spahn H; Reuter K; Mutschler E; Gerok W; Knauf H
Pharmacokinetics of amiloride in renal and hepatic disease.
European journal of clinical pharmacology 1987;33(5):493-8.
1986: Priewer H; Kraft H; Mutschler E
Pharmacodynamics of straight-chain and branched-chain acidic triamterene derivatives.
Arzneimittel-Forschung 1986;36(2):213-5.
1985: Priewer H; Kraft H; Mutschler E
Studies with triamterene derivatives for oral application.
Arzneimittel-Forschung 1985;35(12):1819-21.
1985: Priewer H; Kraft H; Mutschler E
Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene.
Arzneimittel-Forschung 1985;35(11):1688-91.
1985: Priewer H; Kraft H; Mutschler E
Pharmacodynamics of acidic triamterene derivatives and their esters and amides.
Arzneimittel-Forschung 1985;35(10):1544-7.
1985: Knauf H; Reuter K; Mutschler E
Limitation on the use of amiloride in early renal failure.
European journal of clinical pharmacology 1985;28(1):61-6.
1985: Rehders K; Simrock R; Spahn H; Mutschler E; Breddin H K
Plasma salicylate levels and platelet function after acute and chronic administration of slow-release acetylsalicylic acid (Monobeltin).
European journal of clinical pharmacology 1985;27(6):683-7.
1983: Mutschler E; Gilfrich H J; Knauf H; Möhrke W; Völger K D
[Pharmacokinetics of triamterene in healthy subjects and patients with liver and kidney function disorders]
Klinische Wochenschrift 1983;61(18):883-91.
1983: Simrock R; Spahn H; Breddin H K; Mutschler E
[Reversible inhibition of thrombocyte stimulation by acetylsalicylic acid and its role in antithrombotic therapy]
Klinische Wochenschrift 1983;61(6):297-302.
1983: Knauf H; Möhrke W; Mutschler E
Delayed elimination of triamterene and its active metabolite in chronic renal failure.
European journal of clinical pharmacology 1983;24(4):453-6.
1983: Mutschler E; Gilfrich H J; Knauf H; Möhrke W; Völger K D
Pharmacokinetics of triamterene.
Clinical and experimental hypertension. Part A, Theory and practice 1983;5(2):249-69.
1983: Gilfrich H J; Kremer G; Möhrke W; Mutschler E; Völger K D
Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability.
European journal of clinical pharmacology 1983;25(2):237-41.
1982: Reuter K; Knauf H; Mutschler E
[Fluorimetric determination of amiloride in human plasma using thin-layer chromatography]
Journal of chromatography 1982;233():432-6.
1980: Leilich G; Knauf H; Mutschler E; Völger K D
Influence of triamterene and hydroxytriamterene sulfuric acid ester on diuresis and saluresis in rats after oral and intravenous application.
Arzneimittel-Forschung 1980;30(6):949-53.
1980: Knauf H; Möhrke W; Mutschler E; Völger K D
[On the bioavailability of hydrochlorothiazide and triamterene from commercial drugs (author's transl)]
Arzneimittel-Forschung 1980;30(6):1001-4.

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