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Leena Mykkänen

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Auni M Juutilainen; Erkki T Voutilainen; Leena Mykkänen; Leo Niskanen
Plasma aldosterone to renin ratio predicts treatment response in primary aldosteronism: is volume loading needed?
Steven M Haffner; Ralph D'Agostino; Andreas Festa; Richard N Bergman; Leena Mykkänen; Andrew J Karter; Mohammed F Saad; Lynne E Wagenknecht
Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
Johanna Kuusisto; P Lempiäinen; Leena Mykkänen; Markku Laakso
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.

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All Publications

2005: Auni M Juutilainen; Erkki T Voutilainen; Leena Mykkänen; Leo Niskanen
Plasma aldosterone to renin ratio predicts treatment response in primary aldosteronism: is volume loading needed?
Blood pressure 2005;14(4):245-50.
2003: Steven M Haffner; Ralph D'Agostino; Andreas Festa; Richard N Bergman; Leena Mykkänen; Andrew J Karter; Mohammed F Saad; Lynne E Wagenknecht
Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
Diabetes care 2003;26(10):2796-803.
2001: Johanna Kuusisto; P Lempiäinen; Leena Mykkänen; Markku Laakso
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.
Diabetes care 2001;24(9):1629-33.
2001: H Wang; J Rissanen; Raija Miettinen; Päivi Kärkkäinen; Päivi Kekäläinen; Johanna Kuusisto; Leena Mykkänen; Pauli Karhapää; Markku Laakso
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes 2001;50(8):1949-51.
2001: Matti Vanhanen; Miia Kivipelto; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; Kari Kervinen; Y Antero Kesäniemi; Mikko P Laakso; Hilkka Soininen; Markku Laakso
APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
Neurology 2001;56(5):655-9.
2000: Andreas Festa; R D'Agostino; P Rautaharju; Leena Mykkänen; Steven M Haffner
Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects.
The American journal of cardiology 2000;86(10):1117-22.
2000: Anne Maria Koivisto; P Lempiäinen; Keijo Koivisto; Eeva-Liisa Helkala; Leena Mykkänen; Johanna Kuusisto; Kari Kervinen; Y Antero Kesäniemi; Markku Laakso; Hilkka Soininen
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
Neuroepidemiology 2000;19(6):327-32.
2000: Leena Mykkänen
Prevention of coronary heart disease in type 2 diabetes.
International journal of clinical practice. Supplement 2000;(113):40-5.
2000: J Rissanen; H Wang; Raija Miettinen; Päivi Kärkkäinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Pauli Karhapää; Leo Niskanen; Matti Uusitupa; Markku Laakso
Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes care 2000;23(10):1533-8.
2000: Andreas Festa; R D'Agostino; George Howard; Leena Mykkänen; R P Tracy; Steven M Haffner
Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study.
Kidney international 2000;58(4):1703-10.
2000: Jussi Pihlajamäki; Raija Miettinen; RH Valve; L Karjalainen; Leena Mykkänen; Johanna Kuusisto; Samir S Deeb; Johan Auwerx; Markku Laakso
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.
Atherosclerosis 2000;151(2):567-74.
2000: Ilkka Vauhkonen; Leo Niskanen; Leena Mykkänen; Steven M Haffner; M I J Uusitupa; Markku Laakso
Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(2):251-60.
2000: Andreas Festa; Ralph D'Agostino; George Howard; Leena Mykkänen; Russell P Tracy; Steven M Haffner
Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).
Circulation 2000;102(1):42-7.
2000: Steven M Haffner; R D Agostino; Mohammed F Saad; Daniel H O'Leary; Peter J Savage; Marian Rewers; Joseph Selby; Richard N Bergman; Leena Mykkänen
Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study).
The American journal of cardiology 2000;85(12):1395-400.
2000: Andreas Festa; Ralph D'Agostino; CN Hales; Leena Mykkänen; Steven M Haffner
Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects.
Diabetes care 2000;23(5):624-8.
2000: Steven M Haffner; Leena Mykkänen; Andreas Festa; J P Burke; Michael P Stern
Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state.
Circulation 2000;101(9):975-80.
2000: J Rissanen; Ari Markkanen; Päivi Kärkkäinen; Jussi Pihlajamäki; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Pauli Karhapää; Leo Niskanen; Markku Laakso
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.
Diabetes care 2000;23(1):70-3.
1999: Leena Mykkänen; J Kuusisto; Steven M Haffner; M Laakso; M A Austin
LDL size and risk of coronary heart disease in elderly men and women.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2742-8.
1999: Andreas Festa; Ralph D'Agostino; Leena Mykkänen; Russell P Tracy; CN Hales; B V Howard; Steven M Haffner
LDL particle size in relation to insulin, proinsulin, and insulin sensitivity. The Insulin Resistance Atherosclerosis Study.
Diabetes care 1999;22(10):1688-93.
1999: Steven M Haffner; Ralph D'Agostino; D Goff; B Howard; Andreas Festa; Mohammed F Saad; Leena Mykkänen
LDL size in African Americans, Hispanics, and non-Hispanic whites : the insulin resistance atherosclerosis study.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2234-40.
1999: Leena Mykkänen; Daniel J Zaccaro; CN Hales; Andreas Festa; Steven M Haffner
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study.
Diabetologia 1999;42(9):1060-6.
1999: Matti Vanhanen; J Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; PJ Riekkinen; Hilkka Soininen; M Laakso
Type-2 diabetes and cognitive function in a non-demented population.
Acta neurologica Scandinavica 1999;100(2):97-101.
1999: Andreas Festa; Ralph D'Agostino; P Rautaharju; Daniel H O'Leary; Marian Rewers; Leena Mykkänen; Steven M Haffner
Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS).
Stroke; a journal of cerebral circulation 1999;30(8):1566-71.
1999: P Lempiäinen; Leena Mykkänen; Kalevi Pyörälä; Markku Laakso; Johanna Kuusisto
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.
Circulation 1999;100(2):123-8.
1999: Steven M Haffner; Ralph D'Agostino; Leena Mykkänen; Russell Tracy; B Howard; Marian Rewers; Joseph Selby; Peter J Savage; Mohammed F Saad
Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study.
Diabetes care 1999;22(4):562-8.
1999: Steven M Haffner; Leena Mykkänen; David L Rainwater; Pauli Karhapää; M Laakso
Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?
Obesity research 1999;7(2):164-9.
1999: Andreas Festa; Ralph D'Agostino; Leena Mykkänen; Russell Tracy; B V Howard; Steven M Haffner
Low-density lipoprotein particle size is inversely related to plasminogen activator inhibitor-1 levels. The Insulin Resistance Atherosclerosis Study.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):605-10.
1999: Andreas Festa; Ralph D'Agostino; Leena Mykkänen; Russell P Tracy; Daniel J Zaccaro; CN Hales; Steven M Haffner
Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS).
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):562-8.
1999: Leena Mykkänen
[Treatment of hypertension in patients with adult-onset diabetes].
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1147-53.
1998: Samir S Deeb; Lluis Fajas; M Nemoto; J Pihlajamäki; Leena Mykkänen; J Kuusisto; M Laakso; W Fujimoto; J Auwerx
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.
Nature genetics 1998;20(3):284-7.
1998: Steven M Haffner; H Miettinen; Leena Mykkänen; Michael P Stern
Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non-diabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(9):899-905.
1998: Steven M Haffner; Ralph D'Agostino; Leena Mykkänen; CN Hales; Peter J Savage; Richard N Bergman; D O'Leary; Marian Rewers; Joseph Selby; Russell Tracy; Mohammed F Saad
Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study.
Stroke; a journal of cerebral circulation 1998;29(8):1498-503.
1998: Steven M Haffner; Leena Mykkänen; C C Gonzalez; Michael P Stern
Leptin concentrations do not predict weight gain: the Mexico City Diabetes Study.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(7):695-9.
1998: J Rissanen; L Saarinen; Sami Heikkinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Samir S Deeb; Markku Laakso
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
Diabetes care 1998;21(7):1194-7.
1998: Leena Mykkänen; Daniel J Zaccaro; Lynne E Wagenknecht; David C Robbins; M Gabriel; Steven M Haffner
Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study.
Diabetes 1998;47(5):793-800.
1998: Matti Vanhanen; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; PJ Riekkinen; Hilkka Soininen; Markku Laakso
Cognitive function in an elderly population with persistent impaired glucose tolerance.
Diabetes care 1998;21(3):398-402.
1997: Leena Mykkänen; Steven M Haffner; CN Hales; T Rönnemaa; M Laakso
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects.
Diabetes 1997;46(12):1990-5.
1997: J Rissanen; Jussi Pihlajamäki; Sami Heikkinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; A Kolle; Markku Laakso
New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.
Diabetologia 1997;40(11):1313-9.
1997: Johanna Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Matti Vanhanen; Tuomo Hänninen; Kari Kervinen; Y Antero Kesäniemi; PJ Riekkinen; Markku Laakso
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.
BMJ (Clinical research ed.) 1997;315(7115):1045-9.
1997: Steven M Haffner; Leena Mykkänen; Michael P Stern
Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy.
American journal of epidemiology 1997;146(7):581-5.
1997: Leena Mykkänen; Daniel J Zaccaro; Daniel H O'Leary; George Howard; David C Robbins; Steven M Haffner
Microalbuminuria and carotid artery intima-media thickness in nondiabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS).
Stroke; a journal of cerebral circulation 1997;28(9):1710-6.
1997: Leena Mykkänen; Steven M Haffner; Tapani Rönnemaa; R N Bergman; Markku Laakso
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.
American journal of epidemiology 1997;146(4):315-21.
1997: Leena Mykkänen; Steven M Haffner; David L Rainwater; Pauli Karhapää; H Miettinen; M Laakso
Relationship of LDL size to insulin sensitivity in normoglycemic men.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1447-53.
1997: Steven M Haffner; C Gonzalez; Leena Mykkänen; Michael P Stern
Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: the Mexico City Diabetes Study.
Diabetologia 1997;40(7):830-7.
1997: Steven M Haffner; H Miettinen; Pauli Karhapää; Leena Mykkänen; M Laakso
Leptin concentrations, sex hormones, and cortisol in nondiabetic men.
The Journal of clinical endocrinology and metabolism 1997;82(6):1807-9.
1997: Steven M Haffner; H Miettinen; Leena Mykkänen; Pauli Karhapää; David L Rainwater; M Laakso
Leptin concentrations and insulin sensitivity in normoglycemic men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(5):393-9.
1997: Steven M Haffner; George Howard; Elizabeth J Mayer-Davis; Richard N Bergman; Peter J Savage; Marian Rewers; Leena Mykkänen; Andrew J Karter; Richard Hamman; Mohammed F Saad
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study.
Diabetes 1997;46(1):63-9.
1996: Steven M Haffner; M Laakso; H Miettinen; Leena Mykkänen; Pauli Karhapää; David L Rainwater
Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men.
The Journal of clinical endocrinology and metabolism 1996;81(10):3697-701.
1996: Steven M Haffner; Ralph D'Agostino; Mohammed F Saad; Marian Rewers; Leena Mykkänen; Joseph Selby; George Howard; Peter J Savage; Richard Hamman; L E Wagenknecht
Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites. The Insulin Resistance Atherosclerosis Study.
Diabetes 1996;45(6):742-8.
1995: Steven M Haffner; Leena Mykkänen; D Robbins; R Valdez; H Miettinen; B V Howard; Michael P Stern; R Bowsher
A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects.
Diabetologia 1995;38(11):1328-36.
1995: Leena Mykkänen; Steven M Haffner; Johanna Kuusisto; Kalevi Pyörälä; C N Hales; Markku Laakso
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects.
Diabetologia 1995;38(10):1176-82.
1995: Johanna Kuusisto; Leena Mykkänen; K Kervinen; Y A Kesäniemi; Markku Laakso
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(9):1280-6.
1995: Eeva-Liisa Helkala; Keijo Koivisto; Tuomo Hänninen; Matti Vanhanen; K Kervinen; Johanna Kuusisto; Leena Mykkänen; Y A Kesäniemi; Markku Laakso; PJ Riekkinen
The association of apolipoprotein E polymorphism with memory: a population based study.
Neuroscience letters 1995;191(3):141-4.
1995: Markku Laakso; Mari Malkki; Päivi Kekäläinen; Johanna Kuusisto; Leena Mykkänen; Samir S Deeb
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
Diabetes care 1995;18(3):398-400.
1994: Steven M Haffner; Leena Mykkänen; R A Valdez; Michael P Stern; D L Holloway; A Monterrosa; R R Bowsher
Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome.
The Journal of clinical endocrinology and metabolism 1994;79(6):1806-10.
1994: Steven M Haffner; R R Bowsher; Leena Mykkänen; Helen Hazuda; Braxton D Mitchell; R A Valdez; R Gingerich; A Monterossa; Michael P Stern
Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM.
Diabetes 1994;43(12):1490-3.
1994: Steven M Haffner; Leena Mykkänen; Michael P Stern; M Paidi; B V Howard
Greater effect of diabetes on LDL size in women than in men.
Diabetes care 1994;17(10):1164-71.
1994: Johanna Kuusisto; Keijo Koivisto; K Kervinen; Leena Mykkänen; Eeva-Liisa Helkala; Matti Vanhanen; Tuomo Hänninen; Kalevi Pyörälä; Y A Kesäniemi; PJ Riekkinen
Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.
BMJ (Clinical research ed.) 1994;309(6955):636-8.
1994: Steven M Haffner; Leena Mykkänen; R A Valdez; Michael P Stern
Evaluation of two insulin assays in insulin resistance syndrome (syndrome X).
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(9):1430-7.
1994: Leena Mykkänen; T Rönnemaa; J Marniemi; Steven M Haffner; R Bergman; Markku Laakso
Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1264-71.
1994: Steven M Haffner; R A Valdez; Leena Mykkänen; Michael P Stern; Michael S Katz
Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men.
Metabolism: clinical and experimental 1994;43(5):599-603.
1994: Leena Mykkänen; Johanna Kuusisto; Steven M Haffner; Kalevi Pyörälä; Markku Laakso
Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(4):518-26.
1994: Steven M Haffner; Pauli Karhapää; Leena Mykkänen; M Laakso
Insulin resistance, body fat distribution, and sex hormones in men.
Diabetes 1994;43(2):212-9.
1993: Steven M Haffner; Leena Mykkänen; R A Valdez; Michael S Katz
Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.
The Journal of clinical endocrinology and metabolism 1993;77(6):1610-5.
1993: Johanna Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Matti Vanhanen; Tuomo Hänninen; Kalevi Pyörälä; PJ Riekkinen; Markku Laakso
Essential hypertension and cognitive function. The role of hyperinsulinemia.
Hypertension 1993;22(5):771-9.
1993: Steven M Haffner; Leena Mykkänen; R A Valdez; M Paidi; Michael P Stern; B V Howard
LDL size and subclass pattern in a biethnic population.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(11):1623-30.
1993: Steven M Haffner; C Gonzales; R A Valdez; Leena Mykkänen; Helen Hazuda; Braxton D Mitchell; A Monterrosa; Michael P Stern
Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study.
Diabetologia 1993;36(10):1002-6.
1993: Steven M Haffner; Leena Mykkänen; Michael P Stern; R A Valdez; J A Heisserman; R R Bowsher
Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects.
Diabetes 1993;42(9):1297-302.
1993: Leena Mykkänen; Johanna Kuusisto; Kalevi Pyörälä; Markku Laakso
Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects.
Diabetologia 1993;36(6):553-9.
1993: Leena Mykkänen; Markku Laakso; Kalevi Pyörälä
High plasma insulin level associated with coronary heart disease in the elderly.
American journal of epidemiology 1993;137(11):1190-202.
1992: Leena Mykkänen; Markku Laakso; Kalevi Pyörälä
Asymptomatic hyperglycemia and atherosclerotic vascular disease in the elderly.
Diabetes care 1992;15(8):1020-30.
1990: Leena Mykkänen; Markku Laakso; Matti Uusitupa; Kalevi Pyörälä
Prevalence of diabetes and impaired glucose tolerance in elderly subjects and their association with obesity and family history of diabetes.
Diabetes care 1990;13(11):1099-105.