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Lawrence Mylin

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Alan M Watson; Megan M Thompson; Lawrence M Mylin; Todd D Schell
Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells.
Angela M Tatum; Lawrence M Mylin; Susan J Bender; Matthew A Fischer; Beth A Vigliotti; M Judith Tevethia; Satvir S Tevethia; Todd D Schell
CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors.
Lawrence M Mylin; Todd D Schell; Mark J Epler; Caroline Kusuma; David Assis; Chelsea Matsko; Alexandra Smith; April Allebach; Satvir S Tevethia
Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones.

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All Publications

2012: Alan M Watson; Megan M Thompson; Lawrence M Mylin; Todd D Schell
Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(12):5549-60.
2008: Angela M Tatum; Lawrence M Mylin; Susan J Bender; Matthew A Fischer; Beth A Vigliotti; M Judith Tevethia; Satvir S Tevethia; Todd D Schell
CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4406-17.
2007: Lawrence M Mylin; Todd D Schell; Mark J Epler; Caroline Kusuma; David Assis; Chelsea Matsko; Alexandra Smith; April Allebach; Satvir S Tevethia
Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones.
Virology 2007;364(1):155-68.
2005: Pavel Otahal; Sandra C Hutchinson; Lawrence M Mylin; M Judith Tevethia; Satvir S Tevethia; Todd D Schell
Inefficient cross-presentation limits the CD8+ T cell response to a subdominant tumor antigen epitope.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):700-12.
2003: Kevin Staveley-O'Carroll; Todd D Schell; Marcela Jimenez; Lawrence M Mylin; M Judith Tevethia; Stephen P Schoenberger; Satvir S Tevethia
In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):697-707.
2002: Todd D Schell; Lawrence M Mylin; Satvir S Tevethia; Sebastian JOYCE
The assembly of functional beta(2)-microglobulin-free MHC class I molecules that interact with peptides and CD8(+) T lymphocytes.
International immunology 2002;14(7):775-82.
2001: Satvir S Tevethia; T Beachy; Todd D Schell; J Lippolis; RS Newmaster; Lawrence M Mylin; M Judith Tevethia
Role of CTL host responses and their implication for tumorigenicity testing and the use of tumour cells as vaccine substrate.
Developments in biologicals 2001;106():109-21; discussion 143-60.
2000: Lawrence M Mylin; Todd D Schell; D Roberts; Mark J Epler; Alina Boesteanu; Edward J Collins; Jeffrey Frelinger; Sebastian JOYCE; Satvir S Tevethia
Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes.
Journal of virology 2000;74(15):6922-34.
1999: Todd D Schell; Lawrence M Mylin; I Georgoff; A K Teresky; Arnold J Levine; Satvir S Tevethia
Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice.
Journal of virology 1999;73(7):5981-93.
1999: Lawrence M Mylin
Context-dependent immunogenicity of an S206G-substituted H-2Db-restricted simian virus 40 large T antigen epitope I variant.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2171-9.
1998: J E Blaney; E Nobusawa; MA Brehm; Robert H Bonneau; Lawrence M Mylin; TM Fu; Yoshihiro Kawaoka; Satvir S Tevethia
Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity.
Journal of virology 1998;72(12):9567-74.
1998: Alina Boesteanu; MA Brehm; Lawrence M Mylin; Gregory J Christianson; Satvir S Tevethia; Derry C Roopenian; Sebastian JOYCE
A molecular basis for how a single TCR interfaces multiple ligands.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4719-27.
1998: RS Newmaster; Lawrence M Mylin; TM Fu; Satvir S Tevethia
Role of a subdominant H-2Kd-restricted SV40 tumor antigen cytotoxic T lymphocyte epitope in tumor rejection.
Virology 1998;244(2):427-41.
1998: TM Fu; Lawrence M Mylin; Todd D Schell; Igor Bacik; G Russ; jon yewdell; Jack R Bennink; Satvir S Tevethia
An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope.
Journal of virology 1998;72(2):1469-81.
1998: Satvir S Tevethia; Lawrence M Mylin; RS Newmaster; Mark J Epler; John A Lednicky; Janet S Butel; M Judith Tevethia
Cytotoxic T lymphocyte recognition sequences as markers for distinguishing among tumour antigens encoded by SV40, BKV and JCV.
Developments in biological standardization 1998;94():329-39.
1997: M Judith Tevethia; Robert H Bonneau; James W Griffith; Lawrence M Mylin
A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.
Journal of virology 1997;71(11):8157-66.
1997: Lawrence M Mylin; James E Hopper
Inducible expression cassettes in yeast: GAL4.
Methods in molecular biology (Clifton, N.J.) 1997;62():131-48.
1995: Lawrence M Mylin; Robert H Bonneau; J D Lippolis; Satvir S Tevethia
Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.
Journal of virology 1995;69(11):6665-77.
1995: J D Lippolis; Lawrence M Mylin; D T Simmons; Satvir S Tevethia
Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen.
Journal of virology 1995;69(5):3134-46.
1995: Lawrence M Mylin; A M Deckhut; Robert H Bonneau; T D Kierstead; M Judith Tevethia; D T Simmons; S S Tevethi
Cytotoxic T lymphocyte escape variants, induced mutations, and synthetic peptides define a dominant H-2Kb-restricted determinant in simian virus 40 tumor antigen.
Virology 1995;208(1):159-72.
1994: Lawrence M Mylin; V L Bushman; R M Long; X Yu; C M Lebo; T E Blank; James E Hopper
SIP1 is a catabolite repression-specific negative regulator of GAL gene expression.
Genetics 1994;137(3):689-700.
1991: Lawrence M Mylin; C J Gerardot; James E Hopper; Robert C Dickson
Sequence conservation in the Saccharomyces and Kluveromyces GAL11 transcription activators suggests functional domains.
Nucleic acids research 1991;19(19):5345-50.
1991: R M Long; Lawrence M Mylin; James E Hopper
GAL11 (SPT13), a transcriptional regulator of diverse yeast genes, affects the phosphorylation state of GAL4, a highly specific transcriptional activator.
Molecular and cellular biology 1991;11(4):2311-4.
1990: Lawrence M Mylin; M Johnston; James E Hopper
Phosphorylated forms of GAL4 are correlated with ability to activate transcription.
Molecular and cellular biology 1990;10(9):4623-9.
1990: Lawrence M Mylin; K J Hofmann; Loren D Schultz; James E Hopper
Regulated GAL4 expression cassette providing controllable and high-level output from high-copy galactose promoters in yeast.
Methods in enzymology 1990;185():297-308.
1989: Lawrence M Mylin; J P Bhat; James E Hopper
Regulated phosphorylation and dephosphorylation of GAL4, a transcriptional activator.
Genes & development 1989;3(8):1157-65.
1987: Loren D Schultz; K J Hofmann; Lawrence M Mylin; Donna L Montgomery; R W Ellis; James E Hopper
Regulated overproduction of the GAL4 gene product greatly increases expression from galactose-inducible promoters on multi-copy expression vectors in yeast.
Gene 1987;61(2):123-33.