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Jorge Beleta

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Mónica Aparici; Jorge Beleta; Carla Carcasona; Julio Cortijo; Jorge De Alba; Amadeu Gavaldà; Mireia Gómez-Angelats; Jordi Gras; Esteban J Morcillo; Raquel Otal; Carles Puig; Israel Ramos; Hamish Ryder; Dolors Vilella; Marisa Viñals; Montserrat Miralpeix
Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
Amadeu Gavaldà; Jordi Gras; Jordi Aubets; Jorge Beleta; Josep Llupià; Jesús Llenas
Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
Joan Taltavull; Dolors Vilella; Hamish Ryder; Jordi Serrat; Míriam Andrés; Jorge Beleta; Elena Calama; Mònica Córdoba; Amadeu Gavaldà; Jordi Gràcia; Begoña Hernández; Montserrat Miralpeix; José Luis Montero; Lluís Pagès
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.

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All Publications

2012: Mónica Aparici; Jorge Beleta; Carla Carcasona; Julio Cortijo; Jorge De Alba; Amadeu Gavaldà; Mireia Gómez-Angelats; Jordi Gras; Esteban J Morcillo; Raquel Otal; Carles Puig; Israel Ramos; Hamish Ryder; Dolors Vilella; Marisa Viñals; Montserrat Miralpeix
Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
The Journal of pharmacology and experimental therapeutics 2012;342(2):497-509.
2012: Amadeu Gavaldà; Jordi Gras; Jordi Aubets; Jorge Beleta; Josep Llupià; Jesús Llenas
Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
Life sciences 2012;90(7-8):301-5.
2011: Joan Taltavull; Dolors Vilella; Hamish Ryder; Jordi Serrat; Míriam Andrés; Jorge Beleta; Elena Calama; Mònica Córdoba; Amadeu Gavaldà; Jordi Gràcia; Begoña Hernández; Montserrat Miralpeix; José Luis Montero; Lluís Pagès
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
European journal of medicinal chemistry 2011;46(10):4946-56.
2011: Maria Prat; María Antonia Buil; Maria Dolors Fernández; Jordi Castro; Juan Manuel Monleón; Laia Tort; Gaspar Casals; Manuel Ferrer; Josep Maria Huerta; Sònia Espinosa; Manuel López; Victor Segarra; Amadeu Gavaldà; Montserrat Miralpeix; Israel Ramos; Dolors Vilella; Marisa González; Mònica Córdoba; Alvaro Cárdenas; Francisca Antón; Jorge Beleta; Hamish Ryder
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Bioorganic & medicinal chemistry letters 2011;21(11):3457-61.
2010: Joan Taltavull; Jordi Serrat; Jordi Gràcia; Amadeu Gavaldà; Míriam Andrés; Mónica Córdoba; Montserrat Miralpeix; Dolors Vilella; Jorge Beleta; Hamish Ryder; Lluís Pagès
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
Journal of medicinal chemistry 2010;53(19):6912-22.
2010: F Mori; Silvia Pérez-Torres; R De Caro; A Porzionato; V Macchi; Jorge Beleta; A Gavaldà; José M Palacios; Guadalupe Mengod
The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.
Journal of chemical neuroanatomy 2010;40(1):36-42.
2010: Sonia Sentellas; Israel Ramos; Joan Albertí; Miquel Salvà; Francisca Antón; Montserrat Miralpeix; Jorge Beleta; Amadeu Gavaldà
Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;39(5):283-90.
2009: Amadeu Gavaldà; Montserrat Miralpeix; Israel Ramos; Raquel Otal; Cristina Carreño; Marisa Viñals; Teresa Doménech; Carla Carcasona; Blanca Reyes; Dolors Vilella; Jordi Gras; Julio Cortijo; Esteban J Morcillo; Jesús Llenas; Hamish Ryder; Jorge Beleta
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
The Journal of pharmacology and experimental therapeutics 2009;331(2):740-51.
2009: María Prat; Dolors Fernández; M Antonia Buil; María I Crespo; Gaspar Casals; Manuel Ferrer; Laia Tort; Jordi Castro; Juan M Monleón; Amadeu Gavaldà; Montserrat Miralpeix; Israel Ramos; Teresa Doménech; Dolors Vilella; Francisca Antón; Josep M Huerta; Sonia Espinosa; Manuel López; Sonia Sentellas; Marisa González; Joan Albertí; Victor Segarra; Alvaro Cárdenas; Jorge Beleta; Hamish Ryder
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
Journal of medicinal chemistry 2009;52(16):5076-92.
2008: Montserrat Buceta; Eduardo Domínguez; Marian Castro; José Brea; David Alvarez; Javier Barcala; Luis Valdés; Pedro Alvarez-Calderón; Fernando Domínguez; Bernat Vidal; Jose Luis Díaz; Montse Miralpeix; Jorge Beleta; María Isabel Cadavid; M Isabel Loza
A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.
Biochemical pharmacology 2008;76(7):912-21.
2007: Bernat Vidal; Arsenio Nueda; Cristina Esteve; Teresa Domenech; Sonia Benito; Raquel F Reinoso; Mercè Pont; Marta Calbet; Rosa López; María Isabel Cadavid; M Isabel Loza; Alvaro Cárdenas; Nuria Godessart; Jorge Beleta; Graham Warrellow; Hamish Ryder
Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
Journal of medicinal chemistry 2007;50(11):2732-6.
2006: Mercè Amat; Claudia Benjamim; L M Williams; N Prats; E Terricabras; Jorge Beleta; Steven Kunkel; Nuria Godessart
Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo.
British journal of pharmacology 2006;149(6):666-75.
2006: Cristina Esteve; Arsenio Nueda; José Luis Díaz; Jorge Beleta; Alvaro Cárdenas; Estrella Lozoya; María Isabel Cadavid; M Isabel Loza; Hamish Ryder; Bernat Vidal
New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3642-5.
2006: Arsenio Nueda; Nuria García-Roger; Teresa Domenech; Nuria Godessart; Alvaro Cárdenas; Luis F Santamaría-Babi; Jorge Beleta
Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation.
Cellular immunology 2006;242(1):31-8.
2005: Silvia Fonquerna; Montserrat Miralpeix; Lluís Pagès; Carles Puig; Arantxa Cardús; Francisca Antón; Dolors Vilella; Mónica Aparici; José Prieto; Graham Warrellow; Jorge Beleta; Hamish Ryder
Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(4):1165-7.
2004: Silvia Fonquerna; Montserrat Miralpeix; Lluís Pagès; Carles Puig; Arantxa Cardús; Francisca Antón; Alvaro Cárdenas; Dolors Vilella; Mónica Aparici; Elena Calaf; José Prieto; Jordi Gras; Josep M Huerta; Graham Warrellow; Jorge Beleta; Hamish Ryder
Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
Journal of medicinal chemistry 2004;47(25):6326-37.
2004: Francisco Caturla; Juan-Miguel Jiménez; Nuria Godessart; Mercè Amat; Alvaro Cárdenas; Lídia Soca; Jorge Beleta; Hamish Ryder; María I Crespo
Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2004;47(15):3874-86.
2002: Eva García-Ramallo; Teresa Marques; Neus Prats; Jorge Beleta; Steven Kunkel; Nuria Godessart
Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6467-73.
2002: Vittorio Dal Piaz; Maria Carla Castellana; Claudia Vergelli; Maria Paola Giovannoni; Amadeu Gavaldà; Victor Segarra; Jorge Beleta; Hamish Ryder; José M Palacios
Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents.
Journal of enzyme inhibition and medicinal chemistry 2002;17(4):227-33.
2000: J Bou; T Domènech; J Puig; A Heredia; Jordi Gras; D Fernández-Forner; Jorge Beleta; José M Palacios
Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine.
European journal of pharmacology 2000;410(1):33-41.
2000: María I Crespo; J Gràcia; Carles Puig; A Vega; J Bou; Jorge Beleta; T Doménech; Hamish Ryder; Victor Segarra; José M Palacios
Synthesis and biological evaluation of 2,5-dihydropyrazol.
Bioorganic & medicinal chemistry letters 2000;10(23):2661-4.
2000: Jordi Gras; I Cardelús; Jorge Beleta; R W Gristwood; José M Palacios; Jesús Llenas
Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative.
Arzneimittel-Forschung 2000;50(11):980-6.
2000: A Martínez; Ana Castro; Carmen Gil; Montserrat Miralpeix; Victor Segarra; T Doménech; Jorge Beleta; José M Palacios; Hamish Ryder; Xavier Miró; C Bonet; Josep M Casacuberta; Fernando Azorín; Benjamin Piña; P Puigdoménech
Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors.
Journal of medicinal chemistry 2000;43(4):683-9.
2000: Carles Puig; María I Crespo; Nuria Godessart; J Feixas; J Ibarzo; Juan-Miguel Jiménez; Lídia Soca; I Cardelús; A Heredia; Montserrat Miralpeix; J Puig; Jorge Beleta; J M Huerta; M López; Victor Segarra; Hamish Ryder; José M Palacios
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2000;43(2):214-23.
1999: Josep Bonjoch; Faïza DIABA; G Puigbó; Daniel Solé; Victor Segarra; L Santamaría; Jorge Beleta; Hamish Ryder; José M Palacios
Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483.
Bioorganic & medicinal chemistry 1999;7(12):2891-7.
1999: Jordi Xaus; Annabel F Valledor; Marina Cardó; L Marquès; Jorge Beleta; J M Palacios; Antonio Celada
Adenosine inhibits macrophage colony-stimulating factor-dependent proliferation of macrophages through the induction of p27kip-1 expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4140-9.
1999: Julio Cortijo; V Villagrasa; R Pons; L Berto; M Martí-Cabrera; Magdalena Martinez-Losa; Teresa Domenech; Jorge Beleta; Esteban J Morcillo
Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes.
British journal of pharmacology 1999;127(7):1641-51.
1999: Luis Santamaria-Babi; Rosa Torres; A M Giménez-Arnau; J M Giménez-Camarasa; Hamish Ryder; José M Palacios; Jorge Beleta
Rolipram inhibits staphylococcal enterotoxin B-mediated induction of the human skin-homing receptor on T lymphocytes.
The Journal of investigative dermatology 1999;113(1):82-6.
1999: I Cardelús; Francisca Antón; Jorge Beleta; José M Palacios
Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle.
European journal of pharmacology 1999;374(2):249-54.
1999: Luis Santamaria-Babi; Rosa Torres; Hamish Ryder; Jorge Beleta; José M Palacios
Prostaglandin E2 inhibits SEB-mediated induction of the cutaneous lymphocyte-associated antigen.
International archives of allergy and immunology 1999;118(2-4):351-2.
1998: María I Crespo; Lluís Pagès; A Vega; Victor Segarra; M López; T Doménech; Montserrat Miralpeix; Jorge Beleta; Hamish Ryder; José M Palacios
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.
Journal of medicinal chemistry 1998;41(21):4021-35.
1998: Victor Segarra; María I Crespo; F Pujol; Jorge Beleta; T Doménech; Montserrat Miralpeix; José M Palacios; Ana Castro; Ana Martinez
Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds.
Bioorganic & medicinal chemistry letters 1998;8(5):505-10.
1998: M C Collado; Jorge Beleta; E Martinez; Montserrat Miralpeix; T Domènech; José M Palacios; J Hernández
Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor.
British journal of pharmacology 1998;123(6):1047-54.
1997: Julio Cortijo; M Martí-Cabrera; E Bernabeu; T Domènech; J Bou; Andres Fernandez; Jorge Beleta; José M Palacios; Esteban J Morcillo
Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies.
British journal of pharmacology 1997;122(7):1455-63.
1997: T Doménech; Jorge Beleta; José M Palacios
Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(3):328-34.
1997: Luis Santamaria-Babi; José M Palacios; Jorge Beleta
Inhibition of eotaxin-mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram.
British journal of pharmacology 1997;121(6):1150-4.
1997: Vittorio Dal Piaz; Maria Paola Giovannoni; C Castellana; José M Palacios; Jorge Beleta; T Doménech; Victor Segarra
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.
Journal of medicinal chemistry 1997;40(10):1417-21.
1997: Montserrat Miralpeix; Mercedes Camacho; J López-Belmonte; F Canalías; Jorge Beleta; José M Palacios; Luís Vila
Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: biochemical and pharmacological characterization.
British journal of pharmacology 1997;121(2):171-80.
1995: José M Palacios; Jorge Beleta; Victor Segarra
Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors.
Farmaco (Società chimica italiana : 1989) 1995;50(12):819-27.
1994: T Doménech; Jorge Beleta; Andres Fernandez; R W Gristwood; F Cruz Sánchez; E Tolosa; José M Palacios
Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: comparison with other mammalian species.
Brain research. Molecular brain research 1994;21(1-2):176-80.
1993: Julio Cortijo; J Bou; Jorge Beleta; I Cardelús; Jesús Llenas; Esteban J Morcillo; R W Gristwood
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
British journal of pharmacology 1993;108(2):562-8.
1992: Andres Fernandez; J Puig; Jorge Beleta; T Doménech; J Bou; P Berga; R W Gristwood; D J Roberts
Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis.
European journal of pharmacology 1992;222(2-3):257-64.
1992: R W Gristwood; Jorge Beleta; J Bou; I Cardelús; Andres Fernandez; Jesús Llenas; P Berga
Studies on the cardiac actions of flosequinan in vitro.
British journal of pharmacology 1992;105(4):985-91.