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Bernardo Nadal-Ginard

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Georgina M Ellison; Bernardo Nadal-Ginard; Daniele Torella
Optimizing cardiac repair and regeneration through activation of the endogenous cardiac stem cell compartment.
Vien Khach Lai; José Linares-Palomino; Bernardo Nadal-Ginard; Muhammad Saeed; Achim Treumann; Manuel Galiñanes
The effect of diabetes and poor left ventricular function on bone marrow cell-induced myocardial protection.
Georgina M Ellison; Felipe Fernandez-Vazquez; Manuel Galiñanes; Valentina Galuppo; Jose Manuel Gonzalo-Orden; Claudio Iaconetti; Ciro Indolfi; Armando Pérez de Prado; Claudia Perez-Martinez; Saranya Purushothaman; Andrew Smith; Daniele Torella; Michele Torella; Carla Vicinanza; Cheryl D Waring; Valter Agosti; Carlos Cuellas Ramon; Santo Dellegrottaglie; Bernardo Nadal-Ginard
Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.

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All Publications

2012: Georgina M Ellison; Bernardo Nadal-Ginard; Daniele Torella
Optimizing cardiac repair and regeneration through activation of the endogenous cardiac stem cell compartment.
Journal of cardiovascular translational research 2012;5(5):667-77.
2012: Vien Khach Lai; José Linares-Palomino; Bernardo Nadal-Ginard; Muhammad Saeed; Achim Treumann; Manuel Galiñanes
The effect of diabetes and poor left ventricular function on bone marrow cell-induced myocardial protection.
The Journal of surgical research 2012;174(1):e1-e10.
2011: Georgina M Ellison; Felipe Fernandez-Vazquez; Manuel Galiñanes; Valentina Galuppo; Jose Manuel Gonzalo-Orden; Claudio Iaconetti; Ciro Indolfi; Armando Pérez de Prado; Claudia Perez-Martinez; Saranya Purushothaman; Andrew Smith; Daniele Torella; Michele Torella; Carla Vicinanza; Cheryl D Waring; Valter Agosti; Carlos Cuellas Ramon; Santo Dellegrottaglie; Bernardo Nadal-Ginard
Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.
Journal of the American College of Cardiology 2011;58(9):977-86.
2009: Vien Khach Lai; José Linares-Palomino; Bernardo Nadal-Ginard; Manuel Galiñanes
Bone marrow cell-induced protection of the human myocardium: characterization and mechanism of action.
The Journal of thoracic and cardiovascular surgery 2009;138(6):1400-08.e1.
2007: Georgina M Ellison; Daniele Torella; Ioannis Karakikes; Saranya Purushothaman; Antonio Curcio; Cosimo Gasparri; Ciro Indolfi; N Tim Cable; David F Goldspink; Bernardo Nadal-Ginard
Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.
The Journal of biological chemistry 2007;282(15):11397-409.
2007: Daniele Torella; Georgina M Ellison; Ioannis Karakikes; Bernardo Nadal-Ginard
Resident cardiac stem cells.
Cellular and molecular life sciences : CMLS 2007;64(6):661-73.
2007: Georgina M Ellison; Daniele Torella; Ioannis Karakikes; Bernardo Nadal-Ginard
Myocyte death and renewal: modern concepts of cardiac cellular homeostasis.
Nature clinical practice. Cardiovascular medicine 2007;4 Suppl 1():S52-9.
2007: Daniele Torella; Georgina M Ellison; Ioannis Karakikes; Bernardo Nadal-Ginard
Growth-factor-mediated cardiac stem cell activation in myocardial regeneration.
Nature clinical practice. Cardiovascular medicine 2007;4 Suppl 1():S46-51.
2007: Bernardo Nadal-Ginard; Valentin Fuster
Myocardial cell therapy at the crossroads.
Nature clinical practice. Cardiovascular medicine 2007;4(1):1.
2006: Bernardo Nadal-Ginard; Daniele Torella; Georgina Ellison
[Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's].
Revista española de cardiología 2006;59(11):1175-89.
2006: Chandrashekhar Kubal; Kamlesh Sheth; Bernardo Nadal-Ginard; Manuel Galiñanes
Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans.
The Journal of thoracic and cardiovascular surgery 2006;132(5):1112-8.
2006: Simón Méndez-Ferrer; Georgina M Ellison; Daniele Torella; Bernardo Nadal-Ginard
Resident progenitors and bone marrow stem cells in myocardial renewal and repair.
Nature clinical practice. Cardiovascular medicine 2006;3 Suppl 1():S83-9.
2006: Daniele Torella; Georgina M Ellison; Simón Méndez-Ferrer; Borja Ibanez; Bernardo Nadal-Ginard
Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration.
Nature clinical practice. Cardiovascular medicine 2006;3 Suppl 1():S8-13.
2005: Daniele Torella; Georgina M Ellison; Bernardo Nadal-Ginard; Ciro Indolfi
Cardiac stem and progenitor cell biology for regenerative medicine.
Trends in cardiovascular medicine 2005;15(6):229-36.
2005: Jan Kajstura; Marcello Rota; Brian Whang; Stefano Cascapera; Toru Hosoda; Claudia Bearzi; Daria Nurzynska; Hideko Kasahara; Elias Zias; Massimiliano Bonafé; Bernardo Nadal-Ginard; Daniele Torella; Angelo Nascimbene; Federico Quaini; Konrad Urbanek; Annarosa Leri; Piero Anversa
Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion.
Circulation research 2005;96(1):127-37.
2005: Bernardo Nadal-Ginard; Piero Anversa; Jan Kajstura; Annarosa Leri
Cardiac stem cells and myocardial regeneration.
Novartis Foundation symposium 2005;265():142-54; discussion 155-7, 204-11.
2004: Daniele Torella; Marcello Rota; Daria Nurzynska; Ezio Musso; Alyssa Monsen; Isao Shiraishi; Elias Zias; Kenneth Walsh; Anthony Rosenzweig; Mark A Sussman; Konrad Urbanek; Bernardo Nadal-Ginard; Jan Kajstura; Piero Anversa; Annarosa Leri
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression.
Circulation research 2004;94(4):514-24.
2004: Annarosa Leri; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Some like it plastic.
Circulation research 2004;94(2):132-4.
2004: Jan Kajstura; Annarosa Leri; Clotilde Castaldo; Bernardo Nadal-Ginard; Piero Anversa
Myocyte growth in the failing heart.
The Surgical clinics of North America 2004;84(1):161-77.
2003: Cristina Chimenti; Jan Kajstura; Daniele Torella; Konrad Urbanek; Hubert Heleniak; Claudia Colussi; Franca Di Meglio; Bernardo Nadal-Ginard; Andrea Frustaci; Annarosa Leri; Attilio Maseri; Piero Anversa
Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure.
Circulation research 2003;93(7):604-13.
2003: Antonio P Beltrami; Laura Barlucchi; Daniele Torella; Mathue Baker; Federica Limana; Stefano Chimenti; Hideko Kasahara; Marcello Rota; Ezio Musso; Konrad Urbanek; Annarosa Leri; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Adult cardiac stem cells are multipotent and support myocardial regeneration.
Cell 2003;114(6):763-76.
2003: Konrad Urbanek; Federico Quaini; Giordano Tasca; Daniele Torella; Clotilde Castaldo; Bernardo Nadal-Ginard; Annarosa Leri; Jan Kajstura; Eugenio Quaini; Piero Anversa
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10440-5.
2003: Bernardo Nadal-Ginard; Jan Kajstura; Piero Anversa; Annarosa Leri
A matter of life and death: cardiac myocyte apoptosis and regeneration.
The Journal of clinical investigation 2003;111(10):1457-9.
2003: Piero Anversa; Jan Kajstura; Bernardo Nadal-Ginard; Annarosa Leri
Primitive cells and tissue regeneration.
Circulation research 2003;92(6):579-82.
2003: Bernardo Nadal-Ginard; Jan Kajstura; Annarosa Leri; Piero Anversa
Myocyte death, growth, and regeneration in cardiac hypertrophy and failure.
Circulation research 2003;92(2):139-50.
2003: Annarosa Leri; Sonia Franco; Antonella Zacheo; Laura Barlucchi; Stefano Chimenti; Federica Limana; Bernardo Nadal-Ginard; Jan Kajstura; Piero Anversa; María A Blasco
Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation.
The EMBO journal 2003;22(1):131-9.
2002: Piero Anversa; Bernardo Nadal-Ginard
Cardiac chimerism: methods matter.
Circulation 2002;106(18):e129-31; author reply e129-31.
2002: Bernardo Nadal-Ginard; Piero Anversa
Chimera or not chimera?
Circulation research 2002;90(9):E72.
2002: Federica Limana; Konrad Urbanek; Stefano Chimenti; Federico Quaini; Annarosa Leri; Jan Kajstura; Bernardo Nadal-Ginard; Seigo Izumo; Piero Anversa
bcl-2 overexpression promotes myocyte proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6257-62.
2002: Piero Anversa; Annarosa Leri; Jan Kajstura; Bernardo Nadal-Ginard
Myocyte growth and cardiac repair.
Journal of molecular and cellular cardiology 2002;34(2):91-105.
2002: Piero Anversa; Bernardo Nadal-Ginard
Myocyte renewal and ventricular remodelling.
Nature 2002;415(6868):240-3.
2002: Federico Quaini; Konrad Urbanek; Antonio P Beltrami; Nicoletta Finato; Carlo Alberto Beltrami; Bernardo Nadal-Ginard; Jan Kajstura; Annarosa Leri; Piero Anversa
Chimerism of the transplanted heart.
The New England journal of medicine 2002;346(1):5-15.
2001: F Fiordaliso; Annarosa Leri; Daniela Cesselli; Federica Limana; Bijan Safai; Bernardo Nadal-Ginard; Piero Anversa; Jan Kajstura
Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.
Diabetes 2001;50(10):2363-75.
2001: Donald Orlic; Jan Kajstura; Stefano Chimenti; Federica Limana; I Jakoniuk; Federico Quaini; Bernardo Nadal-Ginard; David M Bodine; Annarosa Leri; Piero Anversa
Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10344-9.
2001: Daniela Cesselli; I Jakoniuk; Laura Barlucchi; Antonio P Beltrami; Thomas H Hintze; Bernardo Nadal-Ginard; Jan Kajstura; Annarosa Leri; Piero Anversa
Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy.
Circulation research 2001;89(3):279-86.
2001: Annarosa Leri; Laura Barlucchi; Federica Limana; A Deptala; Zbigniew Darzynkiewicz; Thomas H Hintze; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8626-31.
2001: Antonio P Beltrami; Konrad Urbanek; Jan Kajstura; SM Yan; Nicoletta Finato; R Bussani; Bernardo Nadal-Ginard; F Silvestri; Annarosa Leri; Carlo Alberto Beltrami; Piero Anversa
Evidence that human cardiac myocytes divide after myocardial infarction.
The New England journal of medicine 2001;344(23):1750-7.
2001: Jan Kajstura; F Fiordaliso; A M Andreoli; Bing Li; Stefano Chimenti; Marvin S Medow; Federica Limana; Bernardo Nadal-Ginard; Annarosa Leri; Piero Anversa
IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.
Diabetes 2001;50(6):1414-24.
2001: Donald Orlic; Jan Kajstura; Stefano Chimenti; I Jakoniuk; Stacie M Anderson; B Li; J Pickel; R McKay; Bernardo Nadal-Ginard; David M Bodine; Annarosa Leri; Piero Anversa
Bone marrow cells regenerate infarcted myocardium.
Nature 2001;410(6829):701-5.
2001: Laura Barlucchi; Annarosa Leri; David Dostal; F Fiordaliso; H Tada; Thomas H Hintze; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure.
Circulation research 2001;88(3):298-304.
2000: Andrea Frustaci; Jan Kajstura; Cristina Chimenti; I Jakoniuk; Annarosa Leri; A Maseri; Bernardo Nadal-Ginard; Piero Anversa
Myocardial cell death in human diabetes.
Circulation research 2000;87(12):1123-32.