Lieve Naesens

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Pintér Gábor; Batta Gyula; Kéki Sándor; Mándi Attila; Komáromi István; Takács-Novák Krisztina; Sztaricskai Ferenc; Röth Erzsébet; Ostorházi Eszter; Rozgonyi Ferenc; Naesens Lieve; Herczegh Pál
Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.
Duque María D; Camps Pelayo; Profire Lenuta; Montaner Silvia; Vázquez Santiago; Sureda Francesc X; Mallol Jordi; López-Querol Marta; Naesens Lieve; De Clercq Erik; Prathalingam S Radhika; Kelly John M
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
Naesens Lieve; Vanderlinden Evelien; Roth Erzsébet; Jeko József; Andrei Graciela; Snoeck Robert; Pannecouque Christophe; Illyés Eszter; Batta Gyula; Herczegh Pál; Sztaricskai Ferenc
Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.

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2009: Pintér Gábor; Batta Gyula; Kéki Sándor; Mándi Attila; Komáromi István; Takács-Novák Krisztina; Sztaricskai Ferenc; Röth Erzsébet; Ostorházi Eszter; Rozgonyi Ferenc; Naesens Lieve; Herczegh Pál
Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.
Journal of medicinal chemistry 2009;52(19):6053-61.
2009: Duque María D; Camps Pelayo; Profire Lenuta; Montaner Silvia; Vázquez Santiago; Sureda Francesc X; Mallol Jordi; López-Querol Marta; Naesens Lieve; De Clercq Erik; Prathalingam S Radhika; Kelly John M
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
Bioorganic & medicinal chemistry 2009;17(8):3198-206.
2009: Naesens Lieve; Vanderlinden Evelien; Roth Erzsébet; Jeko József; Andrei Graciela; Snoeck Robert; Pannecouque Christophe; Illyés Eszter; Batta Gyula; Herczegh Pál; Sztaricskai Ferenc
Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.
Antiviral research 2009;82(1):89-94.
2009: Rajic Zrinka; Butula Ivan; Zorc Branka; Kraljevic Pavelic Sandra; Hock Karlo; Pavelic Kresimir; Naesens Lieve; De Clercq Erik; Balzarini Jan; Przyborowska Monika; Ossowski Tadeusz; Mintas Mladen
Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs.
Chemical biology & drug design 2009;73(3):328-38.
2009: Zoidis Grigoris; Kolocouris Nicolas; Naesens Lieve; De Clercq Erik
Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity.
Bioorganic & medicinal chemistry 2009;17(4):1534-41.
2009: Lenaerts Liesbeth; McVey John H; Baker Andrew H; Denby Laura; Nicklin Stuart; Verbeken Erik; Naesens Lieve
Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting.
The journal of gene medicine 2009;11(2):119-27.
2008: Camps Pelayo; Duque María D; Vázquez Santiago; Naesens Lieve; De Clercq Erik; Sureda Francesc X; López-Querol Marta; Camins Antoni; Pallàs Mercè; Prathalingam S Radhika; Kelly John M; Romero Vanessa; Ivorra Dolores; Cortés Diego
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Bioorganic & medicinal chemistry 2008;16(23):9925-36.
2008: Lenaerts Liesbeth; De Clercq Erik; Naesens Lieve
Clinical features and treatment of adenovirus infections.
Reviews in medical virology 2008;18(6):357-74.
2008: Naesens Lieve; Andrei Graciela; Votruba Ivan; Krecmerová Marcela; Holý Antonín; Neyts Johan; De Clercq Erik; Snoeck Robert
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
2008: Gawin Rafal; De Clercq Erik; Naesens Lieve; Koszytkowska-Stawinska Mariola
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
Bioorganic & medicinal chemistry 2008;16(18):8379-89.
2008: de Castro Sonia; Peromingo M Teresa; Naesens Lieve; Andrei Graciela; Snoeck Robert; Balzarini Jan; Velázquez Sonsoles; Camarasa María-José
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action.
Journal of medicinal chemistry 2008;51(18):5823-32.
2008: Zoidis Grigoris; Tsotinis Andrew; Kolocouris Nicolas; Kelly John M; Prathalingam S Radhika; Naesens Lieve; De Clercq Erik
Design and synthesis of bioactive 1,2-annulated adamantane derivatives.
Organic & biomolecular chemistry 2008;6(17):3177-85.
2008: Camps Pelayo; Gómez Tània; Muñoz-Torrero Diego; Rull Jordi; Sánchez Laura; Boschi Francesca; Comes-Franchini Mauro; Ricci Alfredo; Calvet Teresa; Font-Bardia Mercè; Clercq Erik De; Naesens Lieve
Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent.
The Journal of organic chemistry 2008;73(17):6657-65.
2008: Gazivoda Tatjana; Raic-Malic Silvana; Kristafor Vedran; Makuc Damjan; Plavec Janez; Bratulic Sinisa; Kraljevic-Pavelic Sandra; Pavelic Kresimir; Naesens Lieve; Andrei Graciela; Snoeck Robert; Balzarini Jan; Mintas Mladen
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.
Bioorganic & medicinal chemistry 2008;16(10):5624-34.
2008: Lenaerts L; Kelchtermans H; Geboes L; Matthys P; Verbeken E; De Clercq E; Naesens L
Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection.
Antimicrobial agents and chemotherapy 2008;52(4):1462-71.
2008: Bonnafous Pascale; Boutolleau David; Naesens Lieve; Deback Claire; Gautheret-Dejean Agnès; Agut Henri
Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection.
Antiviral research 2008;77(3):237-40.
2008: Carrouée-Durantel Sandra; Durantel David; Werle-Lapostolle Bettina; Pichoud Christian; Naesens Lieve; Neyts Johan; Trépo Christian; Zoulim Fabien
Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.
Antiviral therapy 2008;13(3):381-8.
2007: McGuigan Christopher; Pathirana Ranjith N; Migliore Marco; Adak Rina; Luoni Giovanna; Jones Arwyn T; Díez-Torrubia Alberto; Camarasa Maria-Jose; Velázquez Sonsoles; Henson Geoffrey; Verbeken Erik; Sienaert Rebecca; Naesens Lieve; Snoeck Robert; Andrei Graciela; Balzarini Jan
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.
The Journal of antimicrobial chemotherapy 2007;60(6):1316-30.
2007: Krecmerová Marcela; Holý Antonín; Pohl Radek; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Journal of medicinal chemistry 2007;50(23):5765-72.
2007: Kolocouris Nicolas; Zoidis Grigoris; Foscolos George B; Fytas George; Prathalingham S Radhika; Kelly John M; Naesens Lieve; De Clercq Erik
Design and synthesis of bioactive adamantane spiro heterocycles.
Bioorganic & medicinal chemistry letters 2007;17(15):4358-62.
2007: Krecmerová Marcela; Holý Antonín; Pískala Alois; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Journal of medicinal chemistry 2007;50(5):1069-77.
2007: Bonnafous Pascale; Naesens Lieve; Petrella Stéphanie; Gautheret-Dejean Agnès; Boutolleau David; Sougakoff Wladimir; Agut Henri
Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet.
Antiviral therapy 2007;12(6):877-88.
2006: De Clercq Erik; Naesens Lieve
In search of effective anti-HHV-6 agents.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006;37 Suppl 1():S82-6.
2006: Naesens Lieve; Bonnafous Pascale; Agut Henri; De Clercq Erik
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006;37 Suppl 1():S69-75.
2006: Naesens Lieve; Stephens Chad E; Andrei Graciela; Loregian Arianna; De Bolle Leen; Snoeck Robert; Sowell J Walter; De Clercq Erik
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses.
Antiviral research 2006;72(1):60-7.
2006: Lenaerts L; Naesens L
Antiviral therapy for adenovirus infections.
Antiviral research 2006;71(2-3):172-80.
2006: Lenaerts L; Daelemans D; Geukens N; De Clercq E; Naesens L
Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor.
FEBS letters 2006;580(16):3937-42.
2006: Zoidis Grigoris; Fytas Christos; Papanastasiou Ioannis; Foscolos George B; Fytas George; Padalko Elizaveta; De Clercq Erik; Naesens Lieve; Neyts Johan; Kolocouris Nicolas
Heterocyclic rimantadine analogues with antiviral activity.
Bioorganic & medicinal chemistry 2006;14(10):3341-8.
2006: Stittelaar Koert J; Neyts Johan; Naesens Lieve; van Amerongen Geert; van Lavieren Rob F; Holý Antonin; De Clercq Erik; Niesters Hubert G M; Fries Edwin; Maas Chantal; Mulder Paul G H; van der Zeijst Ben A M; Osterhaus Albert D M E
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.
Nature 2006;439(7077):745-8.
2005: Lenaerts L; Verbeken E; De Clercq E; Naesens L
Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections.
Antimicrobial agents and chemotherapy 2005;49(11):4689-99.
2005: Kuypers Dirk R J; Vandooren Ann-Karolien; Lerut Evelyne; Evenepoel Pieter; Claes Kathleen; Snoeck Robert; Naesens Lieve; Vanrenterghem Yves
Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(8):1997-2004.
2005: Naesens L; Lenaerts L; Andrei G; Snoeck R; Van Beers D; Holy Antonin; Balzarini Jan; De Clercq Erik
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Antimicrobial agents and chemotherapy 2005;49(3):1010-6.
2005: de Bilderling Georges; Bodart Eddy; Lawson Georges; Tuerlinckx David; Remacle Marc; Naesens Lieve; De Clercq Erik; Snoeck Robert
Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.
Journal of medical virology 2005;75(2):332-5.
2005: De Bolle Leen; Naesens Lieve; De Clercq Erik
Update on human herpesvirus 6 biology, clinical features, and therapy.
Clinical microbiology reviews 2005;18(1):217-45.
2005: De Bolle L; Van Loon J; De Clercq E; Naesens Lieve
Quantitative analysis of human herpesvirus 6 cell tropism.
Journal of medical virology 2005;75(1):76-85.
2005: De Clercq Erik; Andrei G; Balzarini J; Leyssen P; Naesens L; Neyts J; Pannecouque C; Snoeck R; Ying C; Hocková D; Holý A
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2004: Balzarini J; Pannecouque C; Naesens L; Andrei G; Snoeck R; De Clercq E; Hocková D; Holý A
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: De Bolle Leen; Manichanh Chaysavanh; Agut Henri; De Clercq Erik; Naesens Lieve
Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance.
Antiviral research 2004;64(1):17-25.
2004: De Bolle Leen; Hatse Sigrid; Verbeken Erik; De Clercq Erik; Naesens Lieve
Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle.
FEBS letters 2004;560(1-3):25-9.
2004: De Bolle Leen; Andrei Graciela; Snoeck Robert; Zhang Ying; Van Lommel Alfons; Otto Michael; Bousseau Anne; Roy Christine; De Clercq Erik; Naesens Lieve
Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.
Biochemical pharmacology 2004;67(2):325-36.
2003: De Bolle L; Balzarini J; De Clercq E; Naesens L
Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):999-1001.
2003: Sienaert R; Naesens L; Brancale A; Carangio A; Andrei G; Snoeck R; Van Kuilenburg A; De Clercq E; McGuigan C; Balzarini J
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):995-7.
2003: Muus U; De Clercq E; Balzarini J; Naesens L; Meier C
Study of different substituted cyclic and acyclic benzylpronucleotides of d4T relative to their hydrolytic stability and antiviral activity.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):791-5.
2002: Snoeck Robert; Andrei Graciela; Bodaghi Bahram; Lagneaux Laurence; Daelemans Dirk; de Clercq Erik; Neyts Johan; Schols Dominique; Naesens Lieve; Michelson Susan; Bron Dominique; Otto Michael J; Bousseau Anne; Nemecek Conception; Roy Christine
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.
Antiviral research 2002;55(3):413-24.
2002: De Bolle Leen; Michel Detlef; Mertens Thomas; Manichanh Chaysavanh; Agut Henri; De Clercq Erik; Naesens Lieve
Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir.
Molecular pharmacology 2002;62(3):714-21.
2002: van Gelder J; Deferme S; Naesens L; De Clercq E; van den Mooter G; Kinget R; Augustijns P
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(8):924-30.
2002: Holý Antonín; Votruba Ivan; Masojídková Milena; Andrei Graciela; Snoeck Robert; Naesens Lieve; De Clercq Erik; Balzarini Jan
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
Journal of medicinal chemistry 2002;45(9):1918-29.
2002: Ducho Christian; Balzarini Jan; Naesens Lieve; De Clercq Erik; Meier Chris
Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity.
Antiviral chemistry & chemotherapy 2002;13(2):129-41.
2002: Meier Chris; Muus Ulrike; Renze Jürgen; Naesens Lieve; De Clercq Erik; Balzarini Jan
Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity.
Antiviral chemistry & chemotherapy 2002;13(2):101-14.
2002: Deferme S; Van Gelder J; Ingels F; Van den Mooter G; De Buck S; Balzarini J; Naesens L; De Clercq E; Kinget R; Augustijns P
Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.
International journal of pharmaceutics 2002;234(1-2):113-9.
2002: Sienaert Rebecca; Naesens Lieve; Brancale Andrea; De Clercq Erik; McGuigan Christopher; Balzarini Jan
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Molecular pharmacology 2002;61(2):249-54.
2002: Sampath J; Adachi M; Hatse S; Naesens L; Balzarini J; Flatley R M; Matherly L H; Schuetz J D
Role of MRP4 and MRP5 in biology and chemotherapy.
AAPS pharmSci 2002;4(3):E14.
2001: De Clercq E; Naesens L; De Bolle L; Schols D; Zhang Y; Neyts J
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.
Reviews in medical virology 2001;11(6):381-95.
2001: Damian F; Blaton N; Desseyn H; Clou K; Augustijns P; Naesens L; Balzarini J; Kinget R; Van den Mooter G
Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30).
The Journal of pharmacy and pharmacology 2001;53(8):1109-16.
2001: De Clercq E; Andrei G; Snoeck R; De Bolle L; Naesens L; Degrève B; Balzarini J; Zhang Y; Schols D; Leyssen P; Ying C; Neyts J
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):271-85.
2001: Naesens L; De Clercq E
Recent developments in herpesvirus therapy.
Herpes : the journal of the IHMF 2001;8(1):12-6.
2001: Neyts J; Naesens L; Ying C; De Bolle L; De Clercq E
Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.
Antiviral research 2001;49(2):115-20.
2000: Van Gelder J; Deferme S; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1394-6.
2000: Annaert P; Tukker J J; van Gelder J; Naesens L; de Clercq E; van Den Mooter G; Kinget R; Augustijns P
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Journal of pharmaceutical sciences 2000;89(8):1054-62.
2000: Damian F; Blaton N; Naesens L; Balzarini J; Kinget R; Augustijns P; Van den Mooter G
Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(4):311-22.
1999: Balzarini J; Naesens L; Aquaro S; Knispel T; Perno C; De Clercq E; Meier C
Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).
Molecular pharmacology 1999;56(6):1354-61.
1999: Saboulard D; Naesens L; Cahard D; Salgado A; Pathirana R; Velazquez S; McGuigan C; De Clercq E; Balzarini J
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
Molecular pharmacology 1999;56(4):693-704.
1999: Van Gelder J; Witvrouw M; Pannecouque C; Henson G; Bridger G; Naesens L; De Clercq E; Annaert P; Shafiee M; Van den Mooter G; Kinget R; Augustijns P
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
International journal of pharmaceutics 1999;186(2):127-36.
1999: Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Pharmaceutical research 1999;16(7):1035-40.
1999: Hatse S; Naesens L; De Clercq E; Balzarini J
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
Biochemical pharmacology 1999;58(2):311-23.
1999: De Clercq E; Andrei G; Balzarini J; Hatse S; Liekens S; Naesens L; Neyts J; Snoeck R
Antitumor potential of acyclic nucleoside phosphonates.
Nucleosides & nucleotides 1999;18(4-5):759-71.
1999: Naesens L; Hatse S; Segers C; Verbeken E; De Clercq E; Waer M; Balzarini J
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Oncology research 1999;11(4):195-203.
1998: Van den Mooter G; Stas G; Damian F; Naesens L; Balzarini J; Kinget R; Augustijns P
Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig.
Pharmaceutical research 1998;15(11):1799-802.
1998: Hatse S; Naesens L; De Clercq E; Balzarini J
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Biochemical pharmacology 1998;56(7):851-9.
1998: Annaert P; Van Gelder J; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
Pharmaceutical research 1998;15(8):1168-73.
1998: Balzarini J; Naesens L; Verbeken E; Laga M; Van Damme L; Parniak M; Van Mellaert L; Anné J; De Clercq E
Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.
AIDS (London, England) 1998;12(10):1129-38.
1998: Naesens L; Bischofberger N; Augustijns P; Annaert P; Van den Mooter G; Arimilli M N; Kim C U; De Clercq E
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
Antimicrobial agents and chemotherapy 1998;42(7):1568-73.
1998: Hatse S; Naesens L; Degrève B; Segers C; Vandeputte M; Waer M; De Clercq E; Balzarini J
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.
International journal of cancer. Journal international du cancer 1998;76(4):595-600.
1998: Balzarini J; Hatse S; Naesens L; De Clercq E
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Biochimica et biophysica acta 1998;1402(1):29-38.
1998: Snoeck R; Wellens W; Desloovere C; Van Ranst M; Naesens L; De Clercq E; Feenstra L
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].
Journal of medical virology 1998;54(3):219-25.
1998: Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach J L; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Pharmaceutical research 1998;15(2):239-45.
1998: Hartmann K; Kuffer M; Balzarini J; Naesens L; Goldberg M; Erfle V; Goebel F D; De Clercq E; Jindrich J; Holy A; Bischofberger N; Kraft W
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;17(2):120-8.
1998: Naesens L; Cahard D; Salgado A; Bidois L; De Clercq E; McGuigan C; Balzarini J
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.
Advances in experimental medicine and biology 1998;431():753-7.
1998: Hatse S; Naesens L; Degrève B; Vandeputte M; Waer M; De Clercq E; Balzarini J
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.
Advances in experimental medicine and biology 1998;431():605-9.
1997: De Groote K; Naesens L; Balzarini J; Baes M I; Declercq P E
Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes.
Biochemical pharmacology 1997;54(6):713-9.
1997: McGuigan C; Tsang H W; Cahard D; Turner K; Velazquez S; Salgado A; Bidois L; Naesens L; De Clercq E; Balzarini J
Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.
Antiviral research 1997;35(3):195-204.
1997: Balzarini J; Kruining J; Wedgwood O; Pannecouque C; Aquaro S; Perno C F; Naesens L; Witvrouw M; Heijtink R; De Clercq E; McGuigan C
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
1997: Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Pharmaceutical research 1997;14(4):492-6.
1996: Balzarini J; Karlsson A; Aquaro S; Perno C F; Cahard D; Naesens L; De Clercq E; McGuigan C
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7295-9.
1996: Naesens L; Balzarini J; Bischofberger N; De Clercq E
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Antimicrobial agents and chemotherapy 1996;40(1):22-8.
1995: Reymen D; Naesens L; Balzarini J; Holý A; Dvoráková H; De Clercq E
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
Antiviral research 1995;28(4):343-57.
1995: Naesens L; Balzarini J; De Clercq E
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
Postepy biochemii 1995;41(5 Suppl):347-51.
1993: Balzarini J; Naesens L; Bohman C; Pérez-Pérez M J; San-Félix A; Camarasa M J; De Clercq E
Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide).
Biochemical pharmacology 1993;46(1):69-77.
1993: Balzarini J; Holy A; Jindrich J; Naesens L; Snoeck R; Schols D; De Clercq E
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.
Antimicrobial agents and chemotherapy 1993;37(2):332-8.
1993: Naesens L; Neyts J; Balzarini J; Holy A; Rosenberg I; De Clercq E
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Journal of medical virology 1993;39(2):167-72.
1992: Naesens L; Balzarini J; De Clercq E
Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):747-52.
1992: Neyts J; Balzarini J; Naesens L; De Clercq E
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice.
Journal of medical virology 1992;37(1):67-71.
1992: Naesens L; Balzarini J; De Clercq E
Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection.
Clinical chemistry 1992;38(4):480-5.
1991: Naesens L; Balzarini J; De Clercq E
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
Antiviral research 1991;16(1):53-64.
1991: Balzarini J; Naesens L; Slachmuylders J; Niphuis H; Rosenberg I; Holý A; Schellekens H; De Clercq E
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.
AIDS (London, England) 1991;5(1):21-8.
1990: Balzarini J; Naesens L; De Clercq E
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
International journal of cancer. Journal international du cancer 1990;46(2):337-40.
1990: Balzarini J; Sobis H; Naesens L; Vandeputte M; De Clercq E
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
International journal of cancer. Journal international du cancer 1990;45(3):486-9.
1990: Balzarini J; Naesens L; Robins M J; De Clercq E
Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside.
Journal of acquired immune deficiency syndromes 1990;3(12):1140-7.
1989: Naesens L; Balzarini J; Rosenberg I; Holý A; De Clercq E
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1989;8(12):1043-7.
1989: Balzarini J; Naesens L; Herdewijn P; Rosenberg I; Holy A; Pauwels R; Baba M; Johns D G; De Clercq E
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):332-6.

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