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Seiho Nagafuchi

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Mitsuru Watanabe; Hajime Arahata; Tomohito Matsuo; Seiho Nagafuchi; Hirofumi Ochi; Yasumasa Ohyagi; Jun-Ichi Kira
Myopathy in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Naoko Wada; Koji Nishifuji; Taketo Yamada; Jun Kudoh; Nobuyoshi Shimizu; Mitsuru Matsumoto; Leena Peltonen; Seiho Nagafuchi; Masayuki Amagai
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
Seiho Nagafuchi
The role of B cells in regulating the magnitude of immune response.

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2012: Mitsuru Watanabe; Hajime Arahata; Tomohito Matsuo; Seiho Nagafuchi; Hirofumi Ochi; Yasumasa Ohyagi; Jun-Ichi Kira
Myopathy in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Muscle & nerve 2012;45(6):904-8.
2011: Naoko Wada; Koji Nishifuji; Taketo Yamada; Jun Kudoh; Nobuyoshi Shimizu; Mitsuru Matsumoto; Leena Peltonen; Seiho Nagafuchi; Masayuki Amagai
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
The Journal of investigative dermatology 2011;131(2):410-7.
2010: Seiho Nagafuchi
The role of B cells in regulating the magnitude of immune response.
Microbiology and immunology 2010;54(8):487-90.
2010: Seiho Nagafuchi; Hitoshi Katsuta; Keizo Anzai
Rituximab, B-lymphocyte depletion, and beta-cell function.
The New England journal of medicine 2010;362(8):761; author reply 761.
2008: Etsushi Kounoue; Ken-ichi Izumi; Shuichiro Ogawa; S Kondo; Hitoshi Katsuta; Tomoyuki Akashi; Yoshiyuki Niho; Mine Harada; Sadafumi Tamiya; Hironori Kurisaki; Seiho Nagafuchi
The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus-induced diabetes in mice.
Archives of virology 2008;153(7):1223-31.
2007: Seiho Nagafuchi; Kenichi Umene; F Yamanaka; Seiji Oohashi; M Shindo; Hironori Kurisaki; Jun Kudoh; Nobuyoshi Shimizu; Toshiro Hara; Mine Harada
Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations.
Journal of internal medicine 2007;261(6):605-10.
2006: Yumiko Sakai; Toru Maruyama; Hitoshi Katsuta; Kazuhiko Kogawa; Tomoyuki Akashi; Ken-Ichi Izumi; Hiroyuki Tominaga; Suminori Kono; Seiho Nagafuchi; Mine Harada
Patients with dilated cardiomyopathy possess insulin resistance independently of cardiac dysfunction or serum tumor necrosis factor-alpha.
International heart journal 2006;47(6):877-87.
2006: Seiho Nagafuchi; Hitoshi Katsuta; Rimiko Koyanagi-Katsuta; Satoshi Yamasaki; Yasushi Inoue; Kazuya Shimoda; Yukari Ikeda; Mieko Shindo; Eiko Yoshida; Tomohito Matsuo; Yuju Ohno; Kazuhiko Kogawa; Keizo Anzai; Hironori Kurisaki; Jun Kudoh; Mine Harada; Nobuyoshi Shimizu
Autoimmune regulator (AIRE) gene is expressed in human activated CD4+ T-cells and regulated by mitogen-activated protein kinase pathway.
Microbiology and immunology 2006;50(12):979-87.
2005: Shuro Yoshida; Fumihiko Ishikawa; Noriaki Kawano; Kazuya Shimoda; Seiho Nagafuchi; Shinji Shimoda; Masaki Yasukawa; Takaaki Kanemaru; Hiromi Ishibashi; Leonard D Shultz; Mine Harada
Human cord blood--derived cells generate insulin-producing cells in vivo.
Stem cells (Dayton, Ohio) 2005;23(9):1409-16.
2005: Tomoe Tanigawa; Akihiro Hayashida; Mieko Kamou; Eiko Kohno-Yoshida; Hitoshi Katsuta; Yoshikazu Kaji; Seiho Nagafuchi; Mine Harada
[A case of metabolic syndrome with coronary artery disease advanced over 13 years. Case report].
Fukuoka igaku zasshi = Hukuoka acta medica 2005;96(9):346-50.
2005: Seiho Nagafuchi; Hitoshi Katsuta; Yuju Ohno; Yasushi Inoue; Kazuya Shimoda; Kazuhiko Kogawa; Yukari Ikeda; Rimiko Koyanagi-Katsuta; Satoshi Yamasaki; Hiroyuki Tominaga; Sadafumi Tamiya; Tsukuru Umemura; Takeshi Otsuka; Toshihiro Miyamoto; Teruhisa Otsuka; Mine Harada; Jun Kudoh; Nobuyoshi Shimizu
Mitogen-activated protein kinase pathway controls autoimmune regulator (AIRE) gene expression in granulo-monocyte colony stimulating factor (GM-CSF)-stimulated myelomonocytic leukemia OTC-4 cells.
Immunology letters 2005;99(1):130-5.
2005: Shiori Kondo; Tomoyuki Akashi; Hitoshi Katsuta; Ryuichi Iwakiri; Keizo Anzai; Seiho Nagafuchi; Yoshiyuki Niho; Mine Harada
[B cells as key contributors in determining the level of immune responses -B-cell-targeted therapy in patients with autoimmune diseases].
Fukuoka igaku zasshi = Hukuoka acta medica 2005;96(4):86-92.
2005: Hitoshi Katsuta; Rimiko Koyanagi-Katsuta; Masafumi Shiiba; Keizo Anzai; Tarou Irie; Tadateru Aida; Yuko Akehi; Masahiko Nakano; Yohichi Yasunami; Mine Harada; Seiho Nagafuchi; Junko Ono; Tetsuhiko Tachikawa
cDNA microarray analysis after laser microdissection in proliferating islets of partially pancreatectomized mice.
Medical molecular morphology 2005;38(1):30-5.
2005: Patrizia Cavadini; William Vermi; Fabio Facchetti; Stefania Fontana; Seiho Nagafuchi; Evelina Mazzolari; Anna Sediva; Veronica Marrella; Anna Villa; Alain Fischer; Luigi D Notarangelo; Raffaele Badolato
AIRE deficiency in thymus of 2 patients with Omenn syndrome.
The Journal of clinical investigation 2005;115(3):728-32.
2004: Seiho Nagafuchi; Seizaburo Kashiwagi; Jun Hayashi; Hitoshi Katsuta; Hideyuki Ikematsu; Mine Harada
A delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) and intradermal hepatitis B vaccination.
Fukuoka igaku zasshi = Hukuoka acta medica 2004;95(12):305-13.
2004: Yuka Sasaki; Kenji Ihara; Nobuo Matsuura; Hitoshi Kohno; Seiho Nagafuchi; Ryuichi Kuromaru; Koichi Kusuhara; Ryu Takeya; Timothy Hoey; Hideki Sumimoto; Toshiro Hara
Identification of a novel type 1 diabetes susceptibility gene, T-bet.
Human genetics 2004;115(3):177-84.
2004: Satoko Arai; Christina Minjares; Seiho Nagafuchi; Toru Miyazaki
Improved experimental procedures for achieving efficient germ line transmission of nonobese diabetic (NOD)-derived embryonic stem cells.
Experimental diabesity research 2004;5(3):219-26.
2003: Kenichi Aoki; Kazuya Shimoda; Kenji Oritani; Tadashi Matsuda; Kenjirou Kamezaki; Ryuta Muromoto; Akihiko Numata; Sadafumi Tamiya; Takashi Haro; Fumihiko Ishikawa; Ken Takase; Tetsuya Yamamoto; Taro Yumioka; Toshihiro Miyamoto; Koji Nagafuji; Hisashi Gondo; Seiho Nagafuchi; Kei-Ichi Nakayama; Mine Harada
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Experimental hematology 2003;31(12):1317-22.
2002: Kazuya Shimoda; Kenjirou Kamesaki; Akihiko Numata; Kenichi Aoki; Tadashi Matsuda; Kenji Oritani; Sadafumi Tamiya; Kouji Kato; Ken Takase; Rie Imamura; Tetsuya Yamamoto; Toshihiro Miyamoto; Koji Nagafuji; Hisashi Gondo; Seiho Nagafuchi; Kei-Ichi Nakayama; Mine Harada
Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):4707-11.
2002: Seiho Nagafuchi
Epstein-Barr virus survival: expression and release of Fas ligand.
Internal medicine (Tokyo, Japan) 2002;41(8):603-4.
2002: Tomoyuki Akashi; Hiroko Minagawa; Hitoshi Katsuta; Mine Harada; Seiho Nagafuchi
Retrograde intrafamilial transmission of primary herpes simplex virus type 1 infection.
The American journal of medicine 2002;113(1):79-80.
2002: Kazuhiko Kogawa; Jun Kudoh; Seiho Nagafuchi; Shouichi Ohga; Hitoshi Katsuta; Hiromi Ishibashi; Mine Harada; Toshiro Hara; Nobuyoshi Shimizu
Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations.
Clinical immunology (Orlando, Fla.) 2002;103(3 Pt 1):277-83.
2002: Saifuddin Ahmed; Kenji Ihara; Wafaa M Bassuny; Ryuichi Kuromaru; Hitoshi Kohno; Kenichi Miyako; Nobuo Matsuura; I Iwata; Seiho Nagafuchi; Toshiro Hara
Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population.
Genes and immunity 2002;3(2):96-101.
2002: Kazuhiko Kogawa; Seiho Nagafuchi; Hitoshi Katsuta; Jun Kudoh; Sadafumi Tamiya; Yumiko Sakai; Nobuyoshi Shimizu; Mine Harada
Expression of AIRE gene in peripheral monocyte/dendritic cell lineage.
Immunology letters 2002;80(3):195-8.
2001: Kenji Ihara; Saifuddin Ahmed; Futoshi Nakao; N Kinukawa; Ryuichi Kuromaru; Nobuo Matsuura; I Iwata; Seiho Nagafuchi; Hitoshi Kohno; Kenichi Miyako; Toshiro Hara
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population.
Immunogenetics 2001;53(6):447-54.
2000: S Kondo; I Iwata; Keizo Anzai; Tomoyuki Akashi; S Wakana; K Ohkubo; Hitoshi Katsuta; Junko Ono; Tomomi Watanabe; Yoshiyuki Niho; Seiho Nagafuchi
Suppression of insulitis and diabetes in B cell-deficient mice treated with streptozocin: B cells are essential for the TCR clonotype spreading of islet-infiltrating T cells.
International immunology 2000;12(7):1075-83.
1999: Seiho Nagafuchi; Hitoshi Katsuta; Kazuhiko Kogawa; Tomoyuki Akashi; S Kondo; Yumiko Sakai; T Tsukiyama; Daisuke Kitamura; Yoshiyuki Niho; Tomomi Watanabe
Establishment of an embryonic stem (ES) cell line derived from a non-obese diabetic (NOD) mouse: in vivo differentiation into lymphocytes and potential for germ line transmission.
FEBS letters 1999;455(1-2):101-4.
1999: I Iwata; Seiho Nagafuchi; H Nakashima; S Kondo; T Koga; Y Yokogawa; Tomoyuki Akashi; T Shibuya; Y Umeno; T Okeda; S Shibata; S Kono; M Yasunami; Hiroaki Ohkubo; Yoshiyuki Niho
Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese.
Diabetes 1999;48(2):416-9.
1999: Koichi Ohshima; Junji Suzumiya; M Sugihara; Seiho Nagafuchi; Shouichi Ohga; Masahiro Kikuchi
CD95 (Fas) ligand expression of Epstein-Barr virus (EBV)-infected lymphocytes: a possible mechanism of immune evasion in chronic active EBV infection.
Pathology international 1999;49(1):9-13.
1999: K Kashiwagi; Seiho Nagafuchi; N Sekiguchi; A Yamagata; I Iwata; Hirokazu Furuya; M Kato; Yoshiyuki Niho
Troglitazone not only reduced insulin resistance but also improved myotonia in a patient with myotonic dystrophy.
European neurology 1999;41(3):171-2.
1998: Koichi Ohshima; Junji Suzumiya; M Sugihara; Seiho Nagafuchi; Shouichi Ohga; Masahiro Kikuchi
Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome.
Pathology international 1998;48(12):934-43.
1998: T Akashi; Seiho Nagafuchi; K Anzai; Daisuke Kitamura; J Wang; I Taniuchi; Y Niho; T Watanabe
Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice.
Immunology 1998;93(2):238-48.
1998: K Anzai; Seiho Nagafuchi; Y Niho; M Kikuchi; J Ono
Beta2-glycoprotein I-dependent and -independent anticardiolipin antibody in non-obese diabetic (NOD) mice.
Clinical and experimental immunology 1998;111(1):173-80.
1997: Tomoyuki Akashi; Seiho Nagafuchi; Keizo Anzai; S Kondo; Daisuke Kitamura; S Wakana; Junko Ono; M Kikuchi; Yoshiyuki Niho; Tomomi Watanabe
Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice.
International immunology 1997;9(8):1159-64.
1997: Koichi Ohshima; S Kobari; S Kuroiwa; K Nakanishi; Tunefumi Shibuya; Seiho Nagafuchi; Junji Suzumiya; Morishige Takeshita; Masahiro Kikuchi
Heterogeneity of systemic extra-nodal Epstein-Barr virus-associated lympho-histiocytic tumor--ten autopsy cases of human immunodeficiency virus-negative Japanese.
Pathology, research and practice 1997;193(4):257-65.
1997: Seiho Nagafuchi; T Fujisaki; K Ohshima; K Anzai; T Otsuka; H Kikuchi; M Nasu; M Kikuchi; Y Sawae; Y Niho
[Immunodeficiency and carcinogenesis in patients with chronic active Epstein-Barr virus infection].
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases 1997;71(1):56-64.
1993: K Anzai; M Nakamura; Seiho Nagafuchi; R Iwakiri; I Ichinose; K Mitsugi; M Kuroki; Shuji Nakano; Y Niho
Production of anti-cardiolipin antibody in AKR/J mice with streptozocin-induced insulitis and diabetes.
Diabetes research and clinical practice 1993;20(1):29-37.
1992: N Shimono; T Ishimaru; K Takaki; K Okada; Seiho Nagafuchi; K Takemori; T Tsutsui; Y Sawae
Clinical features of patients suffering from Streptococcus milleri infections--a retrospective analysis.
Fukuoka igaku zasshi = Hukuoka acta medica 1992;83(12):420-5.
1992: M Kuroki; M Nakamura; Yasuto Itoyama; Yoshitsugu Tanaka; Hiroshi Shiraki; Eishi Baba; T Esaki; T Tatsumoto; Seiho Nagafuchi; Shuji Nakano
Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):940-8.
1992: M Nakamura; Yasuto Itoyama; M Kuroki; Shuji Nakano; S Kondoh; Seiho Nagafuchi; Jun-ichi Kira; I Ichinose; K Mitsugi; K Anzai
Increase of peripheral B lymphocytes committed to the production of monoreactive and high affinity antibodies to HTLV-1 in patients with HAM/TSP.
Journal of neuroimmunology 1992;37(1-2):35-45.
1992: Tohru Fukai; Hiromi Ishibashi; T Noda; Kazufumi Dohmen; J Kudo; Seiho Nagafuchi; K Sueishi; T Yamasaki; H Sameshima
Nodular regenerative hyperplasia of the liver with portal vein thrombosis and hyperplasia of the adrenal gland.
Gastroenterologia Japonica 1992;27(1):108-14.
1992: M Kuroki; Shuji Nakano; K Mitsugi; I Ichinose; K Anzai; M Nakamura; Seiho Nagafuchi; Y Niho
In vivo comparative therapeutic study of optimal administration of 5-fluorouracil and cisplatin using a newly established HST-1 human squamous-carcinoma cell line.
Cancer chemotherapy and pharmacology 1992;29(4):273-6.
1992: R Iwakiri; T Nakano; M Harada; Seiho Nagafuchi; T Teshima; N Ono; Y Yamamoto; Y Niho
A familial case of hyper-IgM immunodeficiency.
Acta haematologica 1992;88(1):50-4.
1991: M Nakamura; M Kuroki; Jun-ichi Kira; Yasuto Itoyama; Hiroshi Shiraki; N Kuroda; Y Washitani; Shuji Nakano; Seiho Nagafuchi; K Anzai
Elevated antibodies to synthetic peptides of HTLV-1 envelope transmembrane glycoproteins in patients with HAM/TSP.
Journal of neuroimmunology 1991;35(1-3):167-77.
1991: Seiho Nagafuchi; Seizaburo Kashiwagi; K Okada; K Anzai; M Nakamura; Y Nishimura; Takehiko Sasazuki; Y Niho
Reversal of nonresponders and postexposure prophylaxis by intradermal hepatitis B vaccination in Japanese medical personnel.
JAMA : the journal of the American Medical Association 1991;265(20):2679-83.
1991: T Takata; Seiho Nagafuchi; H Tsuda; K Uehira; S Kondo; A Ueda; H Ishii; Y Niho
Lymphocytic interstitial pneumonia associated with a marked increase in monoclonal IgM-kappa-type rheumatoid factor and serum CA19-9.
Japanese journal of medicine 1991;30(1):92-6.
1990: T Tsuru; Hiromi Ishibashi; Eijo Matsuishi; Y Hirata; R Shimamura; Seiho Nagafuchi; Y Niho; F Nanishi; H Kimura; T Kusaba
[Acute renal failure associated with acute type A hepatitis with a mild liver damage].
Fukuoka igaku zasshi = Hukuoka acta medica 1990;81(10):337-41.
1990: R Iwakiri; Seiho Nagafuchi; E Kounoue; M Nakamura; M Kikuchi; Shuji Nakano; Y Niho
Immunohistochemical study of insulitis induced by multiple low doses of streptozocin in CD-1 mice.
Diabetes research and clinical practice 1990;9(1):75-82.
1989: Shuji Nakano; M Nakayama; I Ichinose; K Mitsugi; Seiho Nagafuchi; Y Niho
Characterization of a newly established, TA-4-producing squamous carcinoma cell line derived from metastatic tongue carcinoma.
International journal of cancer. Journal international du cancer 1989;44(2):301-6.
1989: R Iwakiri; Seiho Nagafuchi
Inhibition of streptozocin-induced insulitis and diabetes with lobenzarit in CD-1 mice.
Diabetes 1989;38(5):558-61.
1989: Seiho Nagafuchi; Seizaburo Kashiwagi; Y Tsuji; Y Miyata; R Iwakiri; M Takeshita; Y Niho; M Kikuchi
Delayed-type hypersensitivity skin reaction to HBsAg and immunohistopathologic study of liver in patients with acute type B viral hepatitis.
Microbiology and immunology 1989;33(7):539-48.
1989: Seiho Nagafuchi; K Moriyama; Y Takamatsu; S Hayashi; Y Niho; A Takenaka; Hiroko Minagawa; R Mori
Treatment of disseminated herpes zoster in six severely immunocompromised patients: acyclovir and vidarabine.
Japanese journal of medicine 1989;28(1):100-4.
1988: M Nakamura; Seiho Nagafuchi; E Kounoue; T Okeda; K Yamaguchi; T Koga; Shuji Nakano; R Takaki; Y Niho
The in vivo role of experimentally produced anti-islet-cell-surface-antibodies in the development of diabetes mellitus.
Fukuoka igaku zasshi = Hukuoka acta medica 1988;79(4):300-10.
1988: Seiho Nagafuchi; T Iwahashi; K Higa; T Kusaba; K Dan; R Mori
Delayed type hypersensitivity (DTH) skin reaction to varicella-zoster virus antigen in patients with systemic lupus erythematosus (SLE).
Fukuoka igaku zasshi = Hukuoka acta medica 1988;79(4):311-3.
1987: E Kounoue; Seiho Nagafuchi; M Nakamura; Shuji Nakano; T Koga; M Nakayama; M Mituyama; Y Niho; R Takaki
Encephalomyocarditis (EMC) virus-induced diabetes mellitus prevented by Corynebacterium parvum in mice.
Experientia 1987;43(4):430-1.
1987: R Iwakiri; Seiho Nagafuchi; E Kounoue; Shuji Nakano; T Koga; M Nakayama; M Nakamura; Y Niho
Cyclosporin A enhances streptozocin-induced diabetes in CD-1 mice.
Experientia 1987;43(3):324-7.