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Ryozo Nagai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Living Beings

Anatomy

Chemicals & Drugs

Physiology

Gene Expression Regulation

Disorders

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Japan

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Immunohistochemistry

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Publications

TOP 3
Sekiya Motohiro; Osuga Jun-Ichi; Nagashima Shuichi; Ohshiro Taichi; Igarashi Masaki; Okazaki Hiroaki; Takahashi Manabu; Tazoe Fumiko; Wada Taeko; Ohta Keisuke; Takanashi Mikio; Kumagai Masayoshi; Nishi Makiko; Takase Satoru; Yahagi Naoya; Yagyu Hiroaki; Ohashi Ken; Nagai Ryozo; Kadowaki Takashi; Furukawa Yusuke; Ishibashi Shun
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Sekiya Motohiro; Yahagi Naoya; Tamura Yoshiaki; Okazaki Hiroaki; Igarashi Masaki; Ohta Keisuke; Takanashi Mikio; Kumagai Masayoshi; Takase Satoru; Nishi Makiko; Takeuchi Yoshinori; Izumida Yoshihiko; Kubota Midori; Ohashi Ken; Iizuka Yoko; Yagyu Hiroaki; Gotoda Takanari; Nagai Ryozo; Shimano Hitoshi; Yamada Nobuhiro; Kadowaki Takashi; Ishibashi Shun; Osuga Jun-ichi
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Nishimura Satoshi; Manabe Ichiro; Nagai Ryozo
Adipose tissue inflammation in obesity and metabolic syndrome.

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All Publications

2009: Sekiya Motohiro; Osuga Jun-Ichi; Nagashima Shuichi; Ohshiro Taichi; Igarashi Masaki; Okazaki Hiroaki; Takahashi Manabu; Tazoe Fumiko; Wada Taeko; Ohta Keisuke; Takanashi Mikio; Kumagai Masayoshi; Nishi Makiko; Takase Satoru; Yahagi Naoya; Yagyu Hiroaki; Ohashi Ken; Nagai Ryozo; Kadowaki Takashi; Furukawa Yusuke; Ishibashi Shun
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Cell metabolism 2009;10(3):219-28.
2009: Sekiya Motohiro; Yahagi Naoya; Tamura Yoshiaki; Okazaki Hiroaki; Igarashi Masaki; Ohta Keisuke; Takanashi Mikio; Kumagai Masayoshi; Takase Satoru; Nishi Makiko; Takeuchi Yoshinori; Izumida Yoshihiko; Kubota Midori; Ohashi Ken; Iizuka Yoko; Yagyu Hiroaki; Gotoda Takanari; Nagai Ryozo; Shimano Hitoshi; Yamada Nobuhiro; Kadowaki Takashi; Ishibashi Shun; Osuga Jun-ichi
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Biochemical and biophysical research communications 2009;387(3):511-5.
2009: Nishimura Satoshi; Manabe Ichiro; Nagai Ryozo
Adipose tissue inflammation in obesity and metabolic syndrome.
Discovery medicine 2009;8(41):55-60.
2009: Yagi Nobuhiro; Manabe Ichiro; Tottori Tsuneaki; Ishihara Atsushi; Ogata Fusa; Kim Jong Heon; Nishimura Satoshi; Fujiu Katsuhito; Oishi Yumiko; Itaka Keiji; Kato Yasuki; Yamauchi Masahiro; Nagai Ryozo
A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo.
Cancer research 2009;69(16):6531-8.
2009: Nishimura Satoshi; Manabe Ichiro; Nagasaki Mika; Eto Koji; Yamashita Hiroshi; Ohsugi Mitsuru; Otsu Makoto; Hara Kazuo; Ueki Kohjiro; Sugiura Seiryo; Yoshimura Kotaro; Kadowaki Takashi; Nagai Ryozo
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
Nature medicine 2009;15(8):914-20.
2009: Iwata Hiroshi; Nakamura Kazuto; Sumi Makoto; Ninomiya Mikio; Sakai Yoshiki; Hirata Yoichiro; Akaike Masahi; Igarashi Takashi; Takamoto Shinichi; Nagai Ryozo; Sata Masataka
Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model.
Life sciences 2009;85(5-6):255-61.
2009: Morita Hiroyuki; Nagai Ryozo
[Genomic research in hypertension and cardiovascular diseases]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(6):1095-102.
2009: Ogawa Masahito; Suzuki Jun-ichi; Kosuge Hisanori; Takayama Kiyoshi; Nagai Ryozo; Isobe Mitsuaki
The mechanism of anti-inflammatory effects of prostaglandin E2 receptor 4 activation in murine cardiac transplantation.
Transplantation 2009;87(11):1645-53.
2009: Fukuda Daiju; Enomoto Soichiro; Shirakawa Ibuki; Nagai Ryozo; Sata Masataka
Fluvastatin accelerates re-endothelialization impaired by local sirolimus treatment.
European journal of pharmacology 2009;612(1-3):87-92.
2009: Ishizaka Nobukazu; Ishizaka Yuko; Yamakado Minoru; Toda Eiichi; Koike Kazuhiko; Nagai Ryozo
Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test.
Atherosclerosis 2009;204(2):619-23.
2009: Ogawa Masahito; Suzuki Jun-Ichi; Hirata Yasunobu; Nagai Ryozo; Isobe Mitsuaki
A critical role of COX-2 in the progression of neointimal formation after wire injury in mice.
Expert opinion on therapeutic targets 2009;13(5):505-11.
2009: Awazawa Motoharu; Ueki Kohjiro; Inabe Kazunori; Yamauchi Toshimasa; Kaneko Kazuma; Okazaki Yukiko; Bardeesy Nabeel; Ohnishi Shin; Nagai Ryozo; Kadowaki Takashi
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.
Biochemical and biophysical research communications 2009;382(1):51-6.
2009: Suzuki Toru; Sawaki Daigo; Aizawa Kenichi; Munemasa Yoshiko; Matsumura Takayoshi; Ishida Junichi; Nagai Ryozo
Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis.
The Journal of biological chemistry 2009;284(14):9549-57.
2009: Uno Kansei; Takenaka Katsu; Ebihara Aya; Nawata Kan; Hayashi Naoto; Nagasaki Mika; Sonoda Makoto; Takayuki Ohno; Ono Minoru; Kyo Shunei; Nagai Ryozo; Takamoto Shinichi
Value of live 3D transoesophageal echocardiography in the diagnosis of mitral valve lesions.
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 2009;10(2):350-1.
2009: Atsuta Hiroyuki; Uchiyama Tsuyoshi; Kanai Hiroyoshi; Iso Tatsuya; Tanaka Toru; Suga Tatsuo; Maeno Toshitaka; Arai Masashi; Nagai Ryozo; Kurabayashi Masahiko
Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells.
International journal of cardiology 2009;132(3):411-8.
2009: Nagata Daisuke; Kiyosue Arihiro; Takahashi Masao; Satonaka Hiroshi; Tanaka Kimie; Sata Masataka; Nagano Tetsuo; Nagai Ryozo; Hirata Yasunobu
A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(2):133-9.
2009: Masuzawa Akihiro; Ohno Takayuki; Takamoto Shinichi; Motomura Noboru; Ono Minoru; Fujita Hideo; Ando Jiro; Morita Toshihiro; Hirata Yasunobu; Nagai Ryozo; Hirose Akira; Shigeeda Takashi; Kato Satoshi; Araie Makoto
In early-stage diabetic retinopathy, risk of cardiac events after implantation of sirolimus-eluting stent is higher than after coronary artery bypass surgery.
Journal of cardiology 2009;53(1):86-93.
2009: Hongo Makiko; Ishizaka Nobukazu; Furuta Kyoko; Yahagi Naoya; Saito Kan; Sakurai Ryota; Matsuzaki Gen; Koike Kazuhiko; Nagai Ryozo
Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart.
European journal of pharmacology 2009;604(1-3):87-92.
2009: Watanabe Taku; Kubota Naoto; Ohsugi Mitsuru; Kubota Tetsuya; Takamoto Iseki; Iwabu Masato; Awazawa Motoharu; Katsuyama Hisayuki; Hasegawa Chiaki; Tokuyama Kumpei; Moroi Masao; Sugi Kaoru; Yamauchi Toshimasa; Noda Tetsuo; Nagai Ryozo; Terauchi Yasuo; Tobe Kazuyuki; Ueki Kohjiro; Kadowaki Takashi
Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
The Journal of biological chemistry 2009;284(3):1803-12.
2009: Enomoto Soichiro; Sata Masataka; Fukuda Daiju; Nakamura Kazuto; Nagai Ryozo
Rosuvastatin prevents endothelial cell death and reduces atherosclerotic lesion formation in ApoE-deficient mice.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2009;63(1):19-26.
2009: Suzuki Jun-ichi; Isobe Mitsuaki; Morishita Ryuichi; Nagai Ryozo
Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.
Mediators of inflammation 2009;2009():494928.
2009: Sugiyama Hiroaki; Sahara Makoto; Imai Yasushi; Ono Minoru; Okamoto Koh; Kikuchi Ken; Nagai Ryozo
Infective endocarditis by bartonellaquintana masquerading as antineutrophil cytoplasmic antibody-associated small vessel vasculitis.
Cardiology 2009;114(3):208-11.
2009: Ishizaka Yuko; Ishizaka Nobukazu; Tani Mizuki; Toda Akiko; Toda Ei-Ichi; Koike Kazuhiko; Nagai Ryozo; Yamakado Minoru
Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals.
Kidney & blood pressure research 2009;32(2):141-9.
2008: Okazaki Hiroaki; Igarashi Masaki; Nishi Makiko; Sekiya Motohiro; Tajima Makiko; Takase Satoru; Takanashi Mikio; Ohta Keisuke; Tamura Yoshiaki; Okazaki Sachiko; Yahagi Naoya; Ohashi Ken; Amemiya-Kudo Michiyo; Nakagawa Yoshimi; Nagai Ryozo; Kadowaki Takashi; Osuga Jun-ichi; Ishibashi Shun
Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
The Journal of biological chemistry 2008;283(48):33357-64.
2008: Nakamura Kazuto; Koibuchi Nobutaka; Nishimatsu Hiroaki; Higashikuni Yasutomi; Hirata Yasunobu; Kugiyama Kiyotaka; Nagai Ryozo; Sata Masataka
Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(10):1953-61.
2008: Higashikuni Yasutomi; Nagashima Tamon; Ishizaka Nobukazu; Kinugawa Koichiro; Hirata Yasunobu; Nagai Ryozo
Right aortic arch with mirror image branching and vascular ring.
International journal of cardiology 2008;130(1):e53-5.
2008: Iwata Hiroshi; Ako Junya; Nagai Ryozo
Recurrence of late-acquired incomplete stent apposition following sirolimus-eluting stent implantation.
The Journal of invasive cardiology 2008;20(9):E265-8.
2008: Kohro Takahide; Hayashi Doubun; Okada Yoshihiro; Yamazaki Tsutomu; Nagai Ryozo;
Demographics and changes in medical/interventional treatment of coronary artery disease patients over a 3.5-year period in Japan: the Japanese Coronary Artery Disease Study: trend examination.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(9):1397-402.
2008: Shinoda Yusuke; Ogata Naoshi; Higashikawa Akiro; Manabe Ichiro; Shindo Takayuki; Yamada Takashi; Kugimiya Fumitaka; Ikeda Toshiyuki; Kawamura Naohiro; Kawasaki Yosuke; Tsushima Kensuke; Takeda Norifumi; Nagai Ryozo; Hoshi Kazuto; Nakamura Kozo; Chung Ung-il; Kawaguchi Hiroshi
Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.
The Journal of biological chemistry 2008;283(36):24682-9.
2008: Kamijima Yukari; Ooba Nobuhiro; Yagame Mitsunori; Samizo Kazuo; Shimodozono Yoshihiro; Kageyama Shigeru; Horiguchi Shingo; Nagai Ryozo; Kusunoki Tadashi; Kubota Kiyoshi
Hypertension management in diabetic patients: prescribing trends from 1999 to 2005 in three Japanese university hospitals.
Pharmacoepidemiology and drug safety 2008;17(9):904-11.
2008: Kariya Taro; Imai Yasushi; Murakami Arata; Minegishi Sachito; Katori Tatsuo; Kato Hitoshi; Ajiki Kohsuke; Hirata Yasunobu; Nagai Ryozo
Images in cardiovascular medicine. Markedly dilated right heart 17 years after initial treatment repaired by total right ventricular exclusion and total cavopulmonary connection.
Circulation 2008;118(9):e133-5.
2008: Sekiya Motohiro; Osuga Jun-Ichi; Yahagi Naoya; Okazaki Hiroaki; Tamura Yoshiaki; Igarashi Masaki; Takase Satoru; Harada Kenji; Okazaki Sachiko; Iizuka Yoko; Ohashi Ken; Yagyu Hiroaki; Okazaki Mitsuyo; Gotoda Takanari; Nagai Ryozo; Kadowaki Takashi; Shimano Hitoshi; Yamada Nobuhiro; Ishibashi Shun
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
Journal of lipid research 2008;49(8):1829-38.
2008: Ishizaka Nobukazu; Ishizaka Yuko; Seki George; Nagai Ryozo; Yamakado Minoru; Koike Kazuhiko
Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(8):775-83.
2008: Kubota Naoto; Kubota Tetsuya; Itoh Shinsuke; Kumagai Hiroki; Kozono Hideki; Takamoto Iseki; Mineyama Tomoka; Ogata Hitomi; Tokuyama Kumpei; Ohsugi Mitsuru; Sasako Takayoshi; Moroi Masao; Sugi Kaoru; Kakuta Shigeru; Iwakura Yoichiro; Noda Tetsuo; Ohnishi Shin; Nagai Ryozo; Tobe Kazuyuki; Terauchi Yasuo; Ueki Kohjiro; Kadowaki Takashi
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Cell metabolism 2008;8(1):49-64.
2008: Suzuki Toru; Nagai Ryozo
Molecular markers for cardiovascular disease: cardiovascular biomarkers to proteomic discovery.
Nature clinical practice. Cardiovascular medicine 2008;5(6):295.
2008: Oishi Yumiko; Manabe Ichiro; Tobe Kazuyuki; Ohsugi Mitsuru; Kubota Tetsuya; Fujiu Katsuhito; Maemura Koji; Kubota Naoto; Kadowaki Takashi; Nagai Ryozo
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Nature medicine 2008;14(6):656-66.
2008: Nishimura Satoshi; Seo Kinya; Nagasaki Mika; Hosoya Yumiko; Yamashita Hiroshi; Fujita Hideo; Nagai Ryozo; Sugiura Seiryo
Responses of single-ventricular myocytes to dynamic axial stretching.
Progress in biophysics and molecular biology 2008;97(2-3):282-97.
2008: Matsuzaki Gen; Ishizaka Nobukazu; Furuta Kyoko; Hongo Makiko; Saito Kan; Sakurai Ryota; Koike Kazuhiko; Nagai Ryozo
Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome.
European journal of pharmacology 2008;587(1-3):237-42.
2008: Takeda Ryo; Suzuki Etsu; Takahashi Masao; Oba Shigeyoshi; Nishimatsu Hiroaki; Kimura Kenjiro; Nagano Tetsuo; Nagai Ryozo; Hirata Yasunobu
Calcineurin is critical for sodium-induced neointimal formation in normotensive and hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2871-8.
2008: Takahashi Masao; Suzuki Etsu; Takeda Ryo; Oba Shigeyoshi; Nishimatsu Hiroaki; Kimura Kenjiro; Nagano Tetsuo; Nagai Ryozo; Hirata Yasunobu
Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2879-88.
2008: Wang Guoqin; Watanabe Masafumi; Imai Yasushi; Hara Kazuo; Manabe Ichiro; Maemura Koji; Horikoshi Momoko; Kohro Takahide; Amiya Eisuke; Sugiyama Takao; Fujita Takeshi; Kadowaki Takashi; Yamazaki Tsutomu; Nagai Ryozo
Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population.
International heart journal 2008;49(3):313-27.
2008: Kada Nanae; Suzuki Toru; Aizawa Kenichi; Munemasa Yoshiko; Matsumura Takayoshi; Sawaki Daigo; Nagai Ryozo
Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha.
FEBS letters 2008;582(12):1755-60.
2008: Monzen Koshiro; Ito Yuzuru; Naito Atsuhiko T; Kasai Hiroki; Hiroi Yukio; Hayashi Doubun; Shiojima Ichiro; Yamazaki Tsutomu; Miyazono Kohei; Asashima Makoto; Nagai Ryozo; Komuro Issei
A crucial role of a high mobility group protein HMGA2 in cardiogenesis.
Nature cell biology 2008;10(5):567-74.
2008: Okamoto M; Ohara-Imaizumi M; Kubota N; Hashimoto S; Eto K; Kanno T; Kubota T; Wakui M; Nagai R; Noda M; Nagamatsu S; Kadowaki T
Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration.
Diabetologia 2008;51(5):827-35.
2008: Fujimoto Hajime; Taguchi Jun-Ichi; Imai Yasushi; Ayabe Seiji; Hashimoto Hideki; Kobayashi Hisae; Ogasawara Ken; Aizawa Tadanori; Yamakado Minoru; Nagai Ryozo; Ohno Minoru
Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease.
European heart journal 2008;29(10):1267-74.
2008: Nagai Ryozo; Izumi Tohru; Kurabayashi Masahiko; Daida Hiroyuki; Tojo Taiki; Hasegawa Akira; Miyauchi Katsumi; Hayashi Dobun; Kohro Takahide; Okada Yoshihiro; Yamazaki Tsutomu;
Rationale and design of a study to examine lower targets for low-density lipoprotein-cholesterol and blood pressure in coronary artery disease patients.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(4):515-20.
2008: Matsumoto Miwa; Sata Masataka; Fukuda Daiju; Tanaka Kimie; Soma Masaaki; Hirata Yasunobu; Nagai Ryozo
Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice.
Atherosclerosis 2008;197(2):524-33.
2008: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-ichi; Shimomura Hiroji; Koike Kazuhiko; Seki George; Nagai Ryozo; Yamakado Minoru
Association between cigarette smoking and chronic kidney disease in Japanese men.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(3):485-92.
2008: Kohro Takahide; Furui Yuji; Mitsutake Naohiro; Fujii Ryo; Morita Hiroyuki; Oku Shinya; Ohe Kazuhiko; Nagai Ryozo
The Japanese national health screening and intervention program aimed at preventing worsening of the metabolic syndrome.
International heart journal 2008;49(2):193-203.
2008: Sonoda Makoto; Takenaka Katsu; Uno Kansei; Ebihara Aya; Nagai Ryozo
A larger aortic annulus causes aortic regurgitation and a smaller aortic annulus causes aortic stenosis in bicuspid aortic valve.
Echocardiography (Mount Kisco, N.Y.) 2008;25(3):242-8.
2008: Takeda Norifumi; Seko Yoshinori; Oriuchi Noboru; Nagai Ryozo
Gamma-delta T-cell-mediated dilated cardiomyopathy.
International journal of cardiology 2008;125(1):130-2.
2008: Higashikuni Yasutomi; Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Relationship between blood pressure and chronic kidney disease in the Japanese population: the lower the better even in individuals without hypertension?
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(2):213-9.
2008: Nishimura Satoshi; Manabe Ichiro; Nagasaki Mika; Seo Kinya; Yamashita Hiroshi; Hosoya Yumiko; Ohsugi Mitsuru; Tobe Kazuyuki; Kadowaki Takashi; Nagai Ryozo; Sugiura Seiryo
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.
The Journal of clinical investigation 2008;118(2):710-21.
2008: Munemasa Yoshiko; Suzuki Toru; Aizawa Kenichi; Miyamoto Saku; Imai Yasushi; Matsumura Takayoshi; Horikoshi Masami; Nagai Ryozo
Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.
Molecular and cellular biology 2008;28(3):1171-81.
2008: Tanaka Kimie; Sata Masataka; Natori Takeshi; Kim-Kaneyama Joo-Ri; Nose Kiyoshi; Shibanuma Motoko; Hirata Yasunobu; Nagai Ryozo
Circulating progenitor cells contribute to neointimal formation in nonirradiated chimeric mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):428-36.
2008: Sonoda Makoto; Aoyagi Teruhiko; Takenaka Katsu; Uno Kansei; Nagai Ryozo
A one-year study of the antiatherosclerotic effect of the angiotensin-II receptor blocker losartan in hypertensive patients. A comparison with angiotension-converting enzyme inhibitors.
International heart journal 2008;49(1):95-103.
2008: Ichikawa-Shindo Yuka; Sakurai Takayuki; Kamiyoshi Akiko; Kawate Hisaka; Iinuma Nobuyoshi; Yoshizawa Takahiro; Koyama Teruhide; Fukuchi Junichi; Iimuro Satoshi; Moriyama Nobuo; Kawakami Hayato; Murata Toshinori; Kangawa Kenji; Nagai Ryozo; Shindo Takayuki
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
The Journal of clinical investigation 2008;118(1):29-39.
2008: Tanaka Yo; Sato Kae; Shimizu Tatsuya; Yamato Masayuki; Okano Teruo; Manabe Ichiro; Nagai Ryozo; Kitamori Takehiko
Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars.
Lab on a chip 2008;8(1):58-61.
2008: Fukuda Daiju; Sata Masataka; Ishizaka Nobukazu; Nagai Ryozo
Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(1):90-6.
2008: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-ichi; Koike Kazuhiko; Yamakado Minoru; Nagai Ryozo
Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men?
Arteriosclerosis, thrombosis, and vascular biology 2008;28(1):160-5.
2008: Huang Po-Hsun; Sata Masataka; Nishimatsu Hiroaki; Sumi Makoto; Hirata Yasunobu; Nagai Ryozo
Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2008;62(1):46-52.
2007: Saito Kan; Ito Takafumi; Asashima Nobuko; Ohno Minoru; Nagai Ryozo; Fujita Hiromi; Koizumi Nobuo; Takano Ai; Watanabe Haruo; Kawabata Hiroki
Case report: Borrelia valaisiana infection in a Japanese man associated with traveling to foreign countries.
The American journal of tropical medicine and hygiene 2007;77(6):1124-7.
2007: Fujita Masatoshi; Yamazaki Tsutomu; Hayashi Dobun; Kohro Takahide; Okada Yoshihiro; Nagai Ryozo;
Comparison of cardiovascular events in patients with angiographically documented coronary narrowing with combined renin-angiotensin system inhibitor plus statin versus renin-angiotensin system inhibitor alone versus statin alone (from the Japanese Coronary Artery Disease Study).
The American journal of cardiology 2007;100(12):1750-3.
2007: Kohro Takahide; Hayashi Dobun; Okada Yoshihiro; Yamazaki Tsutomu; Nagai Ryozo;
Effects of medication on cardiovascular events in the Japanese coronary artery disease (JCAD) study.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(12):1835-40.
2007: Horikoshi M; Hara K; Ito C; Shojima N; Nagai R; Ueki K; Froguel P; Kadowaki T
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(12):2461-6.
2007: Ishizaka Nobukazu; Nagai Ryozo; Ishizaka Yuko; Toda Ei-Ichi; Yamakado Minoru; Hashimoto Hideki
Comparison of several metabolic syndrome definitions with relation to early carotid atherosclerosis in Japanese men.
Atherosclerosis 2007;195(2):e216-7; author reply e218-9.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Koike Kazuhiko; Seki George; Nagai Ryozo; Yamakado Minoru
Association between obesity and chronic kidney disease in Japanese: differences in gender and hypertensive status?
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(11):1059-64.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Koike Kazuhiko; Seki George; Nagai Ryozo; Yamakado Minoru
Association between chronic kidney disease and carotid intima-media thickening in individuals with hypertension and impaired glucose metabolism.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(11):1035-41.
2007: Yamazaki Tadashi; Suzuki Jun-Ichi; Shimamoto Ryoichi; Tsuji Taeko; Ohmoto-Sekine Yuki; Ohtomo Kuni; Nagai Ryozo
A new therapeutic strategy for hypertrophic nonobstructive cardiomyopathy in humans. A randomized and prospective study with an Angiotensin II receptor blocker.
International heart journal 2007;48(6):715-24.
2007: Ohno Takayuki; Takamoto Shinichi; Motomura Noboru; Ono Minoru; Ando Jiro; Morita Toshihiro; Fujita Hideo; Hirata Yasunobu; Nagai Ryozo; Shigeeda Takashi; Hirose Akira
Coronary artery bypass grafting versus coronary implantation of sirolimus-eluting stents in patients with diabetic retinopathy.
The Annals of thoracic surgery 2007;84(5):1474-8.
2007: Takeuchi Yoshinori; Yahagi Naoya; Nakagawa Yoshimi; Matsuzaka Takashi; Shimizu Ritsuko; Sekiya Motohiro; Iizuka Yoko; Ohashi Ken; Gotoda Takanari; Yamamoto Masayuki; Nagai Ryozo; Kadowaki Takashi; Yamada Nobuhiro; Osuga Jun-Ichi; Shimano Hitoshi
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.
Biochemical and biophysical research communications 2007;363(2):329-35.
2007: Takeda Norihiko; Maemura Koji; Horie Shuichi; Oishi Katsutaka; Imai Yasushi; Harada Tomohiro; Saito Tetsuya; Shiga Taro; Amiya Eisuke; Manabe Ichiro; Ishida Norio; Nagai Ryozo
Thrombomodulin is a clock-controlled gene in vascular endothelial cells.
The Journal of biological chemistry 2007;282(45):32561-7.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Koike Kazuhiko; Hashimoto Hideki; Yamakado Minoru
Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women.
Diabetes research and clinical practice 2007;78(1):72-6.
2007: Ohmoto-Sekine Yuki; Suzuki Jun-ichi; Shimamoto Ryoichi; Yamazaki Tadashi; Tsuji Taeko; Nagai Ryozo; Ohtomo Kuni
Gender-specific clinical characteristics of deep Q waves in hypertrophic cardiomyopathy.
Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University 2007;4(3):274-83.
2007: Tsuji Taeko; Suzuki Jun-ichi; Shimamoto Ryoichi; Yamazaki Tadashi; Ohomoto Yuki; Iwasawa Kuniaki; Nagai Ryozo
Morbidity prevalence rate of kawasaki disease assessed by single cross-sectional history-taking.
International heart journal 2007;48(5):615-21.
2007: Takimoto Yoshiyuki; Maeda Shoichi; Slingsby Brian Taylor; Harada Kenji; Nagase Takahide; Nagawa Hirokazu; Nagai Ryozo; Akabayashi Akira
A template for informed consent forms in medical examination and treatment: an intervention study.
Medical science monitor : international medical journal of experimental and clinical research 2007;13(8):PH15-8.
2007: Suzuki Toru; Nagai Ryozo
Cardiovascular proteomic analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;855(1):28-34.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Nagai Ryozo; Toda Ei-Ichi; Hashimoto Hideki; Yamakado Minoru
Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals.
Atherosclerosis 2007;193(2):373-9.
2007: Kubota Naoto; Yano Wataru; Kubota Tetsuya; Yamauchi Toshimasa; Itoh Shinsuke; Kumagai Hiroki; Kozono Hideki; Takamoto Iseki; Okamoto Shiki; Shiuchi Tetsuya; Suzuki Ryo; Satoh Hidemi; Tsuchida Atsushi; Moroi Masao; Sugi Kaoru; Noda Tetsuo; Ebinuma Hiroyuki; Ueta Yoichi; Kondo Tatsuya; Araki Eiichi; Ezaki Osamu; Nagai Ryozo; Tobe Kazuyuki; Terauchi Yasuo; Ueki Kohjiro; Minokoshi Yasuhiko; Kadowaki Takashi
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Cell metabolism 2007;6(1):55-68.
2007: Yamazaki Tsutomu; Goto Shinya; Shigematsu Hiroshi; Shimada Kazuyuki; Uchiyama Shinichiro; Nagai Ryozo; Yamada Nobuhiro; Matsumoto Masayasu; Origasa Hideki; Bhatt Deepak L; Steg P Gabriel; Ikeda Yasuo;
Prevalence, awareness and treatment of cardiovascular risk factors in patients at high risk of atherothrombosis in Japan.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(7):995-1003.
2007: Kada Nanae; Suzuki Toru; Aizawa Kenichi; Matsumura Takayoshi; Ishibashi Naoto; Suzuki Naomi; Takeda Norifumi; Munemasa Yoshiko; Sawaki Daigo; Ishikawa Takashi; Nagai Ryozo
Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1535-41.
2007: Sekiya Motohiro; Yahagi Naoya; Matsuzaka Takashi; Takeuchi Yoshinori; Nakagawa Yoshimi; Takahashi Haruka; Okazaki Hiroaki; Iizuka Yoko; Ohashi Ken; Gotoda Takanari; Ishibashi Shun; Nagai Ryozo; Yamazaki Tsutomu; Kadowaki Takashi; Yamada Nobuhiro; Osuga Jun-ichi; Shimano Hitoshi
SREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Journal of lipid research 2007;48(7):1581-91.
2007: Seko Yoshinori; Yagita Hideo; Okumura Ko; Azuma Miyuki; Nagai Ryozo
Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.
Cardiovascular research 2007;75(1):158-67.
2007: Nishimura Satoshi; Manabe Ichiro; Nagasaki Mika; Hosoya Yumiko; Yamashita Hiroshi; Fujita Hideo; Ohsugi Mitsuru; Tobe Kazuyuki; Kadowaki Takashi; Nagai Ryozo; Sugiura Seiryo
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.
Diabetes 2007;56(6):1517-26.
2007: Nakamura Kazuto; Sata Masataka; Iwata Hiroshi; Sakai Yoshiki; Hirata Yasunobu; Kugiyama Kiyotaka; Nagai Ryozo
A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart.
Clinical science (London, England : 1979) 2007;112(12):607-16.
2007: Seko Yoshinori; Matsumoto Akihiro; Fukuda Taira; Imai Yasushi; Fujimura Tsutomu; Taka Hikari; Mineki Reiko; Murayama Kimie; Hirata Yasunobu; Nagai Ryozo
A case of neonatal lupus erythematosus presenting delayed dilated cardiomyopathy with circulating autoantibody to annexin A6.
International heart journal 2007;48(3):407-15.
2007: Sumi Makoto; Sata Masataka; Hashimoto Ayako; Imaizumi Takashi; Yanaga Katsuhiko; Ohki Takao; Mori Toyoki; Nagai Ryozo
OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2007;61(4):209-15.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals.
Atherosclerosis 2007;192(1):131-7.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Is metabolic syndrome a risk factor for carotid atherosclerosis in normotensive and prehypertensive individuals?
Journal of atherosclerosis and thrombosis 2007;14(2):72-7.
2007: Ohno Takayuki; Takamoto Shinichi; Ando Jiro; Morita Toshihiro; Fujita Hideo; Hirata Yasunobu; Shigeeda Takashi; Hirose Akira; Nagai Ryozo
Diabetic retinopathy and coronary implantation of sirolimus-eluting stents.
Journal of interventional cardiology 2007;20(2):122-31.
2007: Sumi Makoto; Sata Masataka; Miura Shin-ichiro; Rye Kerry-Anne; Toya Naoki; Kanaoka Yuji; Yanaga Katsuhiko; Ohki Takao; Saku Keijiro; Nagai Ryozo
Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):813-8.
2007: Horikoshi M; Hara K; Ito C; Nagai R; Froguel P; Kadowaki T
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(4):747-51.
2007: Hara Kazuo; Yamauchi Toshimasa; Imai Yasushi; Manabe Ichiro; Nagai Ryozo; Kadowaki Takashi
Reduced adiponectin level is associated with severity of coronary artery disease.
International heart journal 2007;48(2):149-53.
2007: Suzuki Toru; Nishi Toshiya; Nagino Tomoko; Sasaki Kana; Aizawa Kenichi; Kada Nanae; Sawaki Daigo; Munemasa Yoshiko; Matsumura Takayoshi; Muto Shinsuke; Sata Masataka; Miyagawa Kiyoshi; Horikoshi Masami; Nagai Ryozo
Functional interaction between the transcription factor Krüppel-like factor 5 and poly(ADP-ribose) polymerase-1 in cardiovascular apoptosis.
The Journal of biological chemistry 2007;282(13):9895-901.
2007: Yamauchi Toshimasa; Nio Yasunori; Maki Toshiyuki; Kobayashi Masaki; Takazawa Takeshi; Iwabu Masato; Okada-Iwabu Miki; Kawamoto Sachiko; Kubota Naoto; Kubota Tetsuya; Ito Yusuke; Kamon Junji; Tsuchida Atsushi; Kumagai Katsuyoshi; Kozono Hideki; Hada Yusuke; Ogata Hitomi; Tokuyama Kumpei; Tsunoda Masaki; Ide Tomohiro; Murakami Kouji; Awazawa Motoharu; Takamoto Iseki; Froguel Philippe; Hara Kazuo; Tobe Kazuyuki; Nagai Ryozo; Ueki Kohjiro; Kadowaki Takashi
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Nature medicine 2007;13(3):332-9.
2007: Ishizaka Nobukazu; Saito Kan; Furuta Kyoko; Matsuzaki Gen; Koike Kazuhiko; Noiri Eisei; Nagai Ryozo
Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(2):195-202.
2007: Maemura Koji; Takeda Norihiko; Nagai Ryozo
Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases.
Journal of pharmacological sciences 2007;103(2):134-8.
2007: Shirakawa Ibuki; Sata Masataka; Saiura Akio; Kaneda Yukari; Yashiro Hisako; Hirata Yasunobu; Makuuchi Masatoshi; Nagai Ryozo
Atorvastatin attenuates transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2007;61(2-3):154-9.
2007: Uchiyama Tsuyoshi; Atsuta Hiroyuki; Utsugi Toshihiro; Oguri Masato; Hasegawa Akira; Nakamura Tetsuya; Nakai Akira; Nakata Masanori; Maruyama Ikuro; Tomura Hideaki; Okajima Fumikazu; Tomono Shoichi; Kawazu Shoji; Nagai Ryozo; Kurabayashi Masahiko
HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function).
Atherosclerosis 2007;190(2):321-9.
2007: Sahara Makoto; Sata Masataka; Morita Toshihiro; Nakamura Kazuto; Hirata Yasunobu; Nagai Ryozo
Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.
Circulation 2007;115(4):509-17.
2007: Terauchi Yasuo; Takamoto Iseki; Kubota Naoto; Matsui Junji; Suzuki Ryo; Komeda Kajuro; Hara Akemi; Toyoda Yukiyasu; Miwa Ichitomo; Aizawa Shinichi; Tsutsumi Shuichi; Tsubamoto Yoshiharu; Hashimoto Shinji; Eto Kazuhiro; Nakamura Akinobu; Noda Mitsuhiko; Tobe Kazuyuki; Aburatani Hiroyuki; Nagai Ryozo; Kadowaki Takashi
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
The Journal of clinical investigation 2007;117(1):246-57.
2007: Sumi Makoto; Sata Masataka; Toya Naoki; Yanaga Katsuhiko; Ohki Takao; Nagai Ryozo
Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis.
Life sciences 2007;80(6):559-65.
2007: Asada Kazuo; Hatano Masaru; Takeda Norihiko; Higashikuni Yasutomi; Saito Kan; Ishizaka Nobukazu; Hirata Yasunobu; Nagai Ryozo
Giant left coronary artery aneurysm in a patient with mixed connective tissue disease.
Internal medicine (Tokyo, Japan) 2007;46(15):1267-8.
2007: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Association between cigarette smoking, white blood cell count, and metabolic syndrome as defined by the Japanese criteria.
Internal medicine (Tokyo, Japan) 2007;46(15):1167-70.
2007: Nishihira Kensaku; Imamura Takuroh; Hatakeyama Kinta; Yamashita Atsushi; Shibata Yoshisato; Date Haruhiko; Manabe Ichiro; Nagai Ryozo; Kitamura Kazuo; Asada Yujiro
Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina.
Thrombosis research 2007;121(2):275-9.
2006: Oishi Yumiko; Manabe Ichiro; Nagai Ryozo
[Krüppel-like transcription factor 5 (KLF5)]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():254-8.
2006: Matsumura Takayoshi; Suzuki Toru; Kada Nanae; Aizawa Kenichi; Munemasa Yoshiko; Nagai Ryozo
Differential serum proteomic analysis in a model of metabolic disease.
Biochemical and biophysical research communications 2006;351(4):965-71.
2006: Nishimura Satoshi; Kawai Yasuo; Nakajima Toshiaki; Hosoya Yumiko; Fujita Hideo; Katoh Masayoshi; Yamashita Hiroshi; Nagai Ryozo; Sugiura Seiryo
Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners.
Cardiovascular research 2006;72(3):403-11.
2006: Ishizaka Nobukazu; Matsuzaki Gen; Saito Kan; Noiri Eisei; Mori Ichiro; Nagai Ryozo
Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat.
Laboratory investigation; a journal of technical methods and pathology 2006;86(12):1285-92.
2006: Hanajiri Kazuyuki; Maruyama Toshiyuki; Kaneko Yukio; Mitsui Hiroshi; Watanabe Shunsuke; Sata Masataka; Nagai Ryozo; Kashima Takeshi; Shibahara Junji; Omata Masao; Matsumoto Yoichiro
Microbubble-induced increase in ablation of liver tumors by high-intensity focused ultrasound.
Hepatology research : the official journal of the Japan Society of Hepatology 2006;36(4):308-14.
2006: Abe Minami; Sata Masataka; Suzuki Etsu; Takeda Ryo; Takahashi Masao; Nishimatsu Hiroaki; Nagata Daisuke; Kangawa Kenji; Matsuo Hisayuki; Nagai Ryozo; Hirata Yasunobu
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells.
Clinical science (London, England : 1979) 2006;111(6):381-7.
2006: Uno Kansei; Takenaka Katsu; Asada Kenichi; Ebihara Aya; Sasaki Kazuno; Komuro Takako; Nagai Ryozo; Motomura Noboru; Ono Minoru; Takamoto Shinichi
Diagnosis of subacute cardiac rupture by contrast echocardiography.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2006;19(11):1401.e9-1401.e11.
2006: Sahara Makoto; Takahashi Toshiyuki; Imai Yasushi; Nakajima Toshiaki; Yao Atsushi; Morita Toshihiro; Hirata Yasunobu; Nagai Ryozo
New insights in the treatment strategy for pulmonary arterial hypertension.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(5):377-86.
2006: Uchiyama Tsuyoshi; Atsuta Hiroyuki; Utsugi Toshihiro; Ohyama Yoshio; Nakamura Tetsuya; Nakai Akira; Nakata Masanori; Maruyama Ikuro; Tomura Hideaki; Okajima Fumikazu; Tomono Shoichi; Kawazu Shoji; Nagai Ryozo; Kurarbayashi Masahiko
Simvastatin induces heat shock factor 1 in vascular endothelial cells.
Atherosclerosis 2006;188(2):265-73.
2006: Usui Shin-ichi; Yao Atsushi; Hatano Masaru; Kohmoto Osami; Takahashi Toshiyuki; Nagai Ryozo; Kinugawa Koichiro
Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(9):1208-15.
2006: Ishizaka Nobukazu; Ishizaka Yuko; Hashimoto Hideki; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Metabolic syndrome may not associate with carotid plaque in subjects with optimal, normal, or high-normal blood pressure.
Hypertension 2006;48(3):411-7.
2006: Doi Hiroshi; Iso Tatsuya; Sato Hiroko; Yamazaki Miki; Matsui Hiroki; Tanaka Toru; Manabe Ichiro; Arai Masashi; Nagai Ryozo; Kurabayashi Masahiko
Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway.
The Journal of biological chemistry 2006;281(39):28555-64.
2006: Kamei Nozomu; Tobe Kazuyuki; Suzuki Ryo; Ohsugi Mitsuru; Watanabe Taku; Kubota Naoto; Ohtsuka-Kowatari Norie; Kumagai Katsuyoshi; Sakamoto Kentaro; Kobayashi Masatoshi; Yamauchi Toshimasa; Ueki Kohjiro; Oishi Yumiko; Nishimura Satoshi; Manabe Ichiro; Hashimoto Haruo; Ohnishi Yasuyuki; Ogata Hitomi; Tokuyama Kumpei; Tsunoda Masaki; Ide Tomohiro; Murakami Koji; Nagai Ryozo; Kadowaki Takashi
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
The Journal of biological chemistry 2006;281(36):26602-14.
2006: Sakamoto Aiko; Okamoto Koji; Ishizaka Nobukazu; Tejima Kazuaki; Hirata Yasunobu; Nagai Ryozo
18F-fluorodeoxyglucose positron emission tomography in a case of retroperitoneal fibrosis.
International heart journal 2006;47(4):645-50.
2006: Saito Yuichiro; Kurabayashi Masahiko; Nakamura Tetsuya; Nagai Ryozo
[Klotho gene]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():403-6.
2006: Nishimura Go; Manabe Ichiro; Tsushima Kensuke; Fujiu Katsuhito; Oishi Yumiko; Imai Yasushi; Maemura Koji; Miyagishi Makoto; Higashi Yujiro; Kondoh Hisato; Nagai Ryozo
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.
Developmental cell 2006;11(1):93-104.
2006: Hara Kazuo; Horikoshi Momoko; Yamauchi Toshimasa; Yago Hirokazu; Miyazaki Osamu; Ebinuma Hiroyuki; Imai Yasushi; Nagai Ryozo; Kadowaki Takashi
Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.
Diabetes care 2006;29(6):1357-62.
2006: Nishimura Satoshi; Nagai Shinya; Sata Masataka; Katoh Masayoshi; Yamashita Hiroshi; Saeki Yasutake; Nagai Ryozo; Sugiura Seiryo
Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.
Molecular and cellular biochemistry 2006;286(1-2):59-65.
2006: Yokoyama Ikuo; Inoue Yusuke; Moritan Toshiyuki; Ohtomo Kuni; Nagai Ryozo
Myocardial glucose utilisation in type II diabetes mellitus patients treated with sulphonylurea drugs.
European journal of nuclear medicine and molecular imaging 2006;33(6):703-8.
2006: Saito Yuichiro; Kurabayashi Masahiko; Nakamura Tetsuya; Nagai Ryozo
[Klotho gene and endothelial function]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2006;43(3):342-4.
2006: Matsumura Takayoshi; Matsumoto Akihiro; Ohno Minoru; Suzuki Shinya; Ohta Miki; Suzuki Etsu; Takenaka Katsu; Hirata Yasunobu; Fujita Toshiro; Nagai Ryozo
A case of cholesterol embolism confirmed by skin biopsy and successfully treated with statins and steroids.
The American journal of the medical sciences 2006;331(5):280-3.
2006: Hara Kazuo; Horikoshi Momoko; Kitazato Hiroji; Ito Chikako; Noda Mitsuhiko; Ohashi Jun; Froguel Philippe; Tokunaga Katsushi; Tobe Kazuyuki; Nagai Ryozo; Kadowaki Takashi
Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.
Diabetes 2006;55(5):1260-4.
2006: Takeda Norifumi; Manabe Ichiro; Shindo Takayuki; Iwata Hiroshi; Iimuro Satoshi; Kagechika Hiroyuki; Shudo Koichi; Nagai Ryozo
Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1177-83.
2006: Horikoshi Momoko; Hara Kazuo; Ohashi Jun; Miyake Kazuaki; Tokunaga Katsushi; Ito Chikako; Kasuga Masato; Nagai Ryozo; Kadowaki Takashi
A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.
Diabetes 2006;55(4):919-23.
2006: Yamazaki Tadashi; Suzuki Jun-ichi; Shimamoto Ryoichi; Tsuji Taeko; Ohmoto Yuki; Toyo-oka Teruhiko; Omata Masao; Ohtomo Kuni; Nagai Ryozo
Focalized contractile impairment at hypertrophied myocardium proven in consideration of wall stress in patients with hypertrophic cardiomyopathy.
International heart journal 2006;47(2):247-58.
2006: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Association between smoking, hematological parameters, and metabolic syndrome in Japanese men.
Diabetes care 2006;29(3):741.
2006: Kubota Naoto; Terauchi Yasuo; Kubota Tetsuya; Kumagai Hiroki; Itoh Shinsuke; Satoh Hidemi; Yano Wataru; Ogata Hitomi; Tokuyama Kumpei; Takamoto Iseki; Mineyama Tomoka; Ishikawa Michiro; Moroi Masao; Sugi Kaoru; Yamauchi Toshimasa; Ueki Kohjiro; Tobe Kazuyuki; Noda Tetsuo; Nagai Ryozo; Kadowaki Takashi
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
The Journal of biological chemistry 2006;281(13):8748-55.
2006: Kawanami Daiji; Maemura Koji; Takeda Norihiko; Harada Tomohiro; Nojiri Takefumi; Saito Tetsuya; Manabe Ichiro; Imai Yasushi; Nagai Ryozo
C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells.
Atherosclerosis 2006;185(1):39-46.
2006: Ma Ji; Kishida Shinya; Wang Guo Qin; Meguro Kentarou; Imuta Hiroyuki; Oonuma Hitoshi; Iida Haruko; Jo Taisuke; Takano Haruhito; Morita Toshihiro; Nagai Ryozo; Nakajima Toshiaki
Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells.
Journal of cardiovascular pharmacology 2006;47(2):314-21.
2006: Kishida Shinya; Nakajima Toshiaki; Ma Ji; Jo Taisuke; Imuta Hiroyuki; Oonuma Hitoshi; Iida Haruko; Takano Haruhito; Morita Toshihiro; Nagai Ryozo
Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells.
International heart journal 2006;47(1):85-93.
2006: Nishimura Satoshi; Nagai Shinya; Katoh Masayoshi; Yamashita Hiroshi; Saeki Yasutake; Okada Jun-ichi; Hisada Toshiaki; Nagai Ryozo; Sugiura Seiryo
Microtubules modulate the stiffness of cardiomyocytes against shear stress.
Circulation research 2006;98(1):81-7.
2006: Takeda Ryo; Nishimatsu Hiroaki; Suzuki Etsu; Satonaka Hiroshi; Nagata Daisuke; Oba Shigeyoshi; Sata Masataka; Takahashi Masao; Yamamoto Yuji; Terauchi Yasuo; Kadowaki Takashi; Kangawa Kenji; Kitamura Tadaichi; Nagai Ryozo; Hirata Yasunobu
Ghrelin improves renal function in mice with ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN 2006;17(1):113-21.
2006: Shimizu Tsutomu; Takeda Norifumi; Takahashi Masao; Imai Yasushi; Ishizaka Nobukazu; Hirata Yasunobu; Nagai Ryozo
Subarachnoid hemorrhage from mycotic aneurysms.
Internal medicine (Tokyo, Japan) 2006;45(20):1189-90.
2006: Sahara Makoto; Takahashi Toshiyuki; Morita Toshihiro; Yao Atsushi; Nagashima Yu; Hirata Yasunobu; Nagai Ryozo
Three-vessel coronary artery disease complicated with congestive heart failure in a highly aged patient with tetralogy of Fallot having undergone palliative surgeries.
Internal medicine (Tokyo, Japan) 2006;45(20):1147-51.
2006: Kawakami Koji; Nakajima Oumi; Morishita Ryuichi; Nagai Ryozo
Targeted anticancer immunotoxins and cytotoxic agents with direct killing moieties.
TheScientificWorldJournal 2006;6():781-90.
2005: Fujiu Katsuhito; Manabe Ichiro; Ishihara Atsushi; Oishi Yumiko; Iwata Hiroshi; Nishimura Go; Shindo Takayuki; Maemura Koji; Kagechika Hiroyuki; Shudo Koichi; Nagai Ryozo
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.
Circulation research 2005;97(11):1132-41.
2005: Saito Kan; Ishizaka Nobukazu; Hara Masumi; Matsuzaki Gen; Sata Masataka; Mori Ichiro; Ohno Minoru; Nagai Ryozo
Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II.
Hypertension 2005;46(5):1180-5.
2005: Monzen Koshiro; Hosoda Toru; Hayashi Doubun; Imai Yasushi; Okawa Yasuhiro; Kohro Takahide; Uozaki Hiroshi; Nishiyama Tomoki; Fukayama Masashi; Nagai Ryozo
The use of a supercooling refrigerator improves the preservation of organ grafts.
Biochemical and biophysical research communications 2005;337(2):534-9.
2005: Ishizaka Nobukazu; Saito Kan; Mori Ichiro; Matsuzaki Gen; Ohno Minoru; Nagai Ryozo
Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2282-8.
2005: Takano Haruhito; Morita Toshihiro; Iida Haruko; Asada Ken-ichi; Kato Masayoshi; Uno Kansei; Hirose Ken; Matsumoto Akihiro; Takenaka Katsu; Hirata Yasunobu; Eto Fumio; Nagai Ryozo; Sato Yoshiaki; Nakajima Toshiaki
Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow.
European journal of applied physiology 2005;95(1):65-73.
2005: Iida Haruko; Jo Taisuke; Iwasawa Kuniaki; Morita Toshihiro; Hikiji Hisako; Takato Tsuyoshi; Toyo-Oka Teruhiko; Nagai Ryozo; Nakajima Toshiaki
Molecular and pharmacological characteristics of transient voltage-dependent K+ currents in cultured human pulmonary arterial smooth muscle cells.
British journal of pharmacology 2005;146(1):49-59.
2005: Sato Hiroko; Sato Mahito; Kanai Hiroyoshi; Uchiyama Tsuyoshi; Iso Tatsuya; Ohyama Yoshio; Sakamoto Hironosuke; Tamura Junichi; Nagai Ryozo; Kurabayashi Masahiko
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.
Cardiovascular research 2005;67(4):714-22.
2005: Nagai R; Suzuki T; Aizawa K; Shindo T; Manabe I
Significance of the transcription factor KLF5 in cardiovascular remodeling.
Journal of thrombosis and haemostasis : JTH 2005;3(8):1569-76.
2005: Imai Yasushi; Taketani Tsuyoshi; Maemura Koji; Takeda Norihiko; Harada Tomohiro; Nojiri Takefumi; Kawanami Daiji; Monzen Koshiro; Hayashi Dobun; Murakawa Yuji; Ohno Minoru; Hirata Yoshinobu; Yamazaki Tsutomu; Takamoto Shinichi; Nagai Ryozo
Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(8):994-5.
2005: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Association between cigarette smoking, metabolic syndrome, and carotid arteriosclerosis in Japanese individuals.
Atherosclerosis 2005;181(2):381-8.
2005: Sahara Makoto; Sata Masataka; Matsuzaki Yumi; Tanaka Kimie; Morita Toshihiro; Hirata Yasunobu; Okano Hideyuki; Nagai Ryozo
Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury.
Stem cells (Dayton, Ohio) 2005;23(7):874-8.
2005: Nishimura Satoshi; Yamashita Hiroshi; Katoh Masayoshi; Yamada Kelly P; Sunagawa Kenji; Saeki Yasutake; Ohnuki Yosiki; Nagai Ryozo; Sugiura Seiryo
Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.
Journal of molecular and cellular cardiology 2005;39(2):231-9.
2005: Najima Yuho; Yahagi Naoya; Takeuchi Yoshinori; Matsuzaka Takashi; Sekiya Motohiro; Nakagawa Yoshimi; Amemiya-Kudo Michiyo; Okazaki Hiroaki; Okazaki Sachiko; Tamura Yoshiaki; Iizuka Yoko; Ohashi Ken; Harada Kenji; Gotoda Takanari; Nagai Ryozo; Kadowaki Takashi; Ishibashi Shun; Yamada Nobuhiro; Osuga Jun-ichi; Shimano Hitoshi
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
The Journal of biological chemistry 2005;280(30):27523-32.
2005: Harada Tomohiro; Nagai Ryozo
[The genetic disorders responsible for sudden cardiac death]
Nippon rinsho. Japanese journal of clinical medicine 2005;63(7):1273-83.
2005: Tanaka Kimie; Sata Masataka; Fukuda Daiju; Suematsu Yoshihiro; Motomura Noboru; Takamoto Shinichi; Hirata Yasunobu; Nagai Ryozo
Age-associated aortic stenosis in apolipoprotein E-deficient mice.
Journal of the American College of Cardiology 2005;46(1):134-41.
2005: Ishikawa Takashi; Fukushima Yasushi; Shiobara Yujiro; Kishimoto Tsuyoshi; Tanno Sakiko; Shoji Ikuo; Suzuki Tetsuro; Matsui Tamano; Shimada Yasushi; Ohyama Takaaki; Nagai Ryozo; Miyamura Tatsuo
Outbreak of hepatitis C virus infection in an outpatient clinic.
Journal of gastroenterology and hepatology 2005;20(7):1087-93.
2005: Hara K; Horikoshi M; Kitazato H; Yamauchi T; Ito C; Noda M; Ohashi J; Froguel P; Tokunaga K; Nagai R; Kadowaki T
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Diabetologia 2005;48(7):1307-14.
2005: Matsumoto Sahohime; Miyagishi Makoto; Akashi Hideo; Nagai Ryozo; Taira Kazunari
Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library.
The Journal of biological chemistry 2005;280(27):25687-96.
2005: Amiya Eisuke; Ishizaka Nobukazu; Watanabe Airi; Endo Yoko; Itou Rei; Yoshida Shigetaka; Nangaku Masahumi; Nagai Ryozo
Retroperitoneal fibrosis with periaortic and pericardial involvement.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(6):760-2.
2005: Jo Taisuke; Iida Haruko; Kishida Shinya; Imuta Hiroyuki; Oonuma Hitoshi; Nagata Taiji; Hara Hajime; Iwasawa Kuniaki; Soma Masaaki; Sato Yoshiaki; Nagase Takahide; Nagai Ryozo; Nakajima Toshiaki
Acute and chronic effects of eicosapentaenoic acid on voltage-gated sodium channel expressed in cultured human bronchial smooth muscle cells.
Biochemical and biophysical research communications 2005;331(4):1452-9.
2005: Yahagi Naoya; Shimano Hitoshi; Hasegawa Kiyoshi; Ohashi Kenichi; Matsuzaka Takashi; Najima Yuho; Sekiya Motohiro; Tomita Sachiko; Okazaki Hiroaki; Tamura Yoshiaki; Iizuka Yoko; Ohashi Ken; Nagai Ryozo; Ishibashi Shun; Kadowaki Takashi; Makuuchi Masatoshi; Ohnishi Shin; Osuga Jun-ichi; Yamada Nobuhiro
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2005;41(9):1316-22.
2005: Suzuki Toru; Aizawa Kenichi; Matsumura Takayoshi; Nagai Ryozo
Vascular implications of the Krüppel-like family of transcription factors.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(6):1135-41.
2005: Suzuki Toru; Matsumura Takayoshi; Nagai Ryozo
Transcriptional regulation at the chromatin level in the cardiovasculature through protein-protein interactions and chemical modifications.
Trends in cardiovascular medicine 2005;15(4):125-9.
2005: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Nagai Ryozo; Yamakado Minoru
Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):1038-44.
2005: Morita Hiroyuki; Saito Yuichiro; Ohashi Noriko; Yoshikawa Masayoshi; Katoh Makoto; Ashida Terunao; Kurihara Hiroki; Nakamura Tetsuya; Kurabayashi Masahiko; Nagai Ryozo
Fluvastatin ameliorates the hyperhomocysteinemia-induced endothelial dysfunction: the antioxidative properties of fluvastatin.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(4):475-80.
2005: Matsumura Takayoshi; Suzuki Toru; Aizawa Kenichi; Munemasa Yoshiko; Muto Shinsuke; Horikoshi Masami; Nagai Ryozo
The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.
The Journal of biological chemistry 2005;280(13):12123-9.
2005: Ishizaka Nobukazu; Saito Kan; Noiri Eisei; Sata Masataka; Ikeda Hitoshi; Ohno Akihiko; Ando Jiro; Mori Ichiro; Ohno Minoru; Nagai Ryozo
Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(4):R1063-70.
2005: Saito Kan; Ishizaka Nobukazu; Aizawa Toru; Sata Masataka; Iso-o Naoyuki; Noiri Eisei; Mori Ichiro; Ohno Minoru; Nagai Ryozo
Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1836-43.
2005: Nishimatsu Hiroaki; Suzuki Etsu; Satonaka Hiroshi; Takeda Ryo; Omata Masao; Fujita Toshiro; Nagai Ryozo; Kitamura Tadaichi; Hirata Yasunobu
Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1770-6.
2005: Taketani Tsuyoshi; Imai Yasushi; Morota Tetsuro; Maemura Koji; Morita Hiroyuki; Hayashi Dobun; Yamazaki Tsutomu; Nagai Ryozo; Takamoto Shinichi
Altered patterns of gene expression specific to thoracic aortic aneurysms: microarray analysis of surgically resected specimens.
International heart journal 2005;46(2):265-77.
2005: Takeda Norifumi; Takahashi Toshiyuki; Seko Yoshinori; Maemura Koji; Nakasone Hideki; Sakamoto Kei; Hirata Yasunobu; Nagai Ryozo
Takayasu myocarditis mediated by cytotoxic T lymphocytes.
Internal medicine (Tokyo, Japan) 2005;44(3):256-60.
2005: Takeda Ryo; Suzuki Etsu; Satonaka Hiroshi; Oba Shigeyoshi; Nishimatsu Hiroaki; Omata Masao; Fujita Toshiro; Nagai Ryozo; Hirata Yasunobu
Blockade of endogenous cytokines mitigates neointimal formation in obese Zucker rats.
Circulation 2005;111(11):1398-406.
2005: Koitabashi Norimichi; Arai Masashi; Tomaru Koichi; Takizawa Takako; Watanabe Atai; Niwano Kazuo; Yokoyama Tomoyuki; Wuytack Frank; Periasamy Muthu; Nagai Ryozo; Kurabayashi Masahiko
Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding.
Biochemical and biophysical research communications 2005;328(1):116-24.
2005: Higashikuni Yasutomi; Sata Masataka; Nagai Ryozo
Reversible left ventricular hypertrophy after tako-tsubo-like cardiomyopathy.
Acta cardiologica 2005;60(1):77-9.
2005: Fukuda Daiju; Sata Masataka; Tanaka Kimie; Nagai Ryozo
Potent inhibitory effect of sirolimus on circulating vascular progenitor cells.
Circulation 2005;111(7):926-31.
2005: Sato Mahito; Kawai-Kowase Keiko; Sato Hiroko; Oyama Yuko; Kanai Hiroyoshi; Ohyama Yoshio; Suga Tatsuo; Maeno Toshitaka; Aoki Yasuhiro; Tamura Junichi; Sakamoto Hironosuke; Nagai Ryozo; Kurabayashi Masahiko
c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):341-7.
2005: Oishi Yumiko; Manabe Ichiro; Tobe Kazuyuki; Tsushima Kensuke; Shindo Takayuki; Fujiu Katsuhito; Nishimura Go; Maemura Koji; Yamauchi Toshimasa; Kubota Naoto; Suzuki Ryo; Kitamura Toshio; Akira Shizuo; Kadowaki Takashi; Nagai Ryozo
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism 2005;1(1):27-39.
2005: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-Ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(1):27-34.
2005: Natori Takeshi; Sata Masataka; Nagai Ryozo; Makuuchi Masatoshi
Cimetidine inhibits angiogenesis and suppresses tumor growth.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59(1-2):56-60.
2005: Yokoyama Ikuo; Inoue Yusuke; Moritan Toshiyuki; Ohtomo Kuni; Nagai Ryozo
Measurement of skeletal muscle glucose utilization by dynamic 18F-FDG PET without arterial blood sampling.
Nuclear medicine communications 2005;26(1):31-7.
2004: Ma Ji; Iida Haruko; Jo Taisuke; Takano Haruhito; Oonuma Hitoshi; Morita Toshihiro; Toyo-Oka Teruhiko; Omata Masao; Nagai Ryozo; Okuda Yukichi; Yamada Nobuhiro; Nakajima Toshiaki
Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells.
European journal of pharmacology 2004;505(1-3):67-74.
2004: Sakurai Susumu; Takenaka Katsu; Shiojima Ichiro; Sonoda Makoto; Uno Kansei; Nakahara Kazuhiko; Nagai Ryozo
Close physical contact of the heart with diaphragm causes pseudo-asynergy of left ventricular inferior wall in normal subjects.
Echocardiography (Mount Kisco, N.Y.) 2004;21(7):573-9.
2004: Fukushima Yasushi; Matsui Toshimitsu; Saitoh Toshihito; Ichinose Masao; Tateishi Keisuke; Shindo Takayuki; Fujishiro Midori; Sakoda Hideyuki; Shojima Nobuhiro; Kushiyama Akifumi; Fukuda Satoru; Anai Motonobu; Ono Hiraku; Oka Masashi; Shimizu Yasuhito; Kurihara Hiroki; Nagai Ryozo; Ishikawa Takashi; Asano Tomoichiro; Omata Masao
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
European journal of pharmacology 2004;502(3):243-52.
2004: Kubota Naoto; Terauchi Yasuo; Tobe Kazuyuki; Yano Wataru; Suzuki Ryo; Ueki Kohjiro; Takamoto Iseki; Satoh Hidemi; Maki Toshiyuki; Kubota Tetsuya; Moroi Masao; Okada-Iwabu Miki; Ezaki Osamu; Nagai Ryozo; Ueta Yoichi; Kadowaki Takashi; Noda Tetsuo
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
The Journal of clinical investigation 2004;114(7):917-27.
2004: Fujimoto Hajime; Ohno Minoru; Ayabe Seiji; Kobayashi Hisae; Ishizaka Nobukazu; Kimura Hiroko; Yoshida Ken-ichi; Nagai Ryozo
Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1848-53.
2004: Saiura Akio; Sata Masataka; Hiasa Ken-ichi; Kitamoto Shiro; Washida Miwa; Egashira Kensuke; Nagai Ryozo; Makuuchi Masatoshi
Antimonocyte chemoattractant protein-1 gene therapy attenuates graft vasculopathy.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1886-90.
2004: Kato Masayoshi; Matsumoto Akihiro; Nakajima Toshiaki; Hirose Ken; Iwasawa Kuniaki; Takenaka Katsu; Yamashita Hiroshi; Sugiura Seiryo; Hirata Yasunobu; Nagai Ryozo
Amlodipine increases nitric oxide production in exhaled air during exercise in patients with essential hypertension.
American journal of hypertension 2004;17(9):729-33.
2004: Hayashi Doubun; Kudoh Sumiyo; Shiojima Ichiro; Zou Yunzeng; Harada Koichiro; Shimoyama Masaki; Imai Yasushi; Monzen Koshiro; Yamazaki Tsutomu; Yazaki Yoshio; Nagai Ryozo; Komuro Issei
Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.
Biochemical and biophysical research communications 2004;322(1):310-9.
2004: Oyama Yuko; Kawai-Kowase Keiko; Sekiguchi Kenichi; Sato Mahito; Sato Hiroko; Yamazaki Miki; Ohyama Yoshio; Aihara Yasushi; Iso Tatsuya; Okamaoto Eichi; Nagai Ryozo; Kurabayashi Masahiko
Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1602-7.
2004: Saito Kan; Ishizaka Nobukazu; Aizawa Toru; Sata Masataka; Iso-O Naoyuki; Noiri Eisei; Ohno Minoru; Nagai Ryozo
Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(8):599-607.
2004: Iimuro Satoshi; Shindo Takayuki; Moriyama Nobuo; Amaki Toshihiro; Niu Pei; Takeda Norifumi; Iwata Hiroshi; Zhang Yuelan; Ebihara Aya; Nagai Ryozo
Angiogenic effects of adrenomedullin in ischemia and tumor growth.
Circulation research 2004;95(4):415-23.
2004: Morita Hiroyuki; Yokoyama Ikuo; Yamada Namie; Uno Kansei; Nagai Ryozo
Usefulness of 18FDG/13N-ammonia PET imaging for evaluation of the cardiac damage in Churg-Strauss syndrome.
European journal of nuclear medicine and molecular imaging 2004;31(8):1218.
2004: Yamashita Tokuyuki; Eto Kazuhiro; Okazaki Yukiko; Yamashita Shigeo; Yamauchi Toshimasa; Sekine Nobuo; Nagai Ryozo; Noda Mitsuhiko; Kadowaki Takashi
Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.
Endocrinology 2004;145(8):3566-77.
2004: Sato Mahito; Tanaka Toru; Maemura Koji; Uchiyama Tsuyoshi; Sato Hiroko; Maeno Toshitaka; Suga Tatsuo; Iso Tatsuya; Ohyama Yoshio; Arai Masashi; Tamura Junichi; Sakamoto Hironosuke; Nagai Ryozo; Kurabayashi Masahiko
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.
American journal of respiratory cell and molecular biology 2004;31(2):209-15.
2004: Ikeda Yuichi; Imai Yasushi; Kumagai Hidetoshi; Nosaka Tetsuya; Morikawa Yoshihiro; Hisaoka Tomoko; Manabe Ichiro; Maemura Koji; Nakaoka Takashi; Imamura Takeshi; Miyazono Kohei; Komuro Issei; Nagai Ryozo; Kitamura Toshio
Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10732-7.
2004: Takeda Norihiko; Maemura Koji; Imai Yasushi; Harada Tomohiro; Kawanami Daiji; Nojiri Takefumi; Manabe Ichiro; Nagai Ryozo
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.
Circulation research 2004;95(2):146-53.
2004: Ishizaka Nobukazu; Ishizaka Yuko; Toda Ei-ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Association between white blood cell count and carotid arteriosclerosis in Japanese smokers.
Atherosclerosis 2004;175(1):95-100.
2004: Suzuki Etsu; Satonaka Hiroshi; Nishimatsu Hiroaki; Oba Shigeyoshi; Takeda Ryo; Omata Masao; Fujita Toshiro; Nagai Ryozo; Hirata Yasunobu
Myocyte enhancer factor 2 mediates vascular inflammation via the p38-dependent pathway.
Circulation research 2004;95(1):42-9.
2004: Tsuchida Atsushi; Yamauchi Toshimasa; Ito Yusuke; Hada Yusuke; Maki Toshiyuki; Takekawa Sato; Kamon Junji; Kobayashi Masaki; Suzuki Ryo; Hara Kazuo; Kubota Naoto; Terauchi Yasuo; Froguel Philippe; Nakae Jun; Kasuga Masato; Accili Domenico; Tobe Kazuyuki; Ueki Kohjiro; Nagai Ryozo; Kadowaki Takashi
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
The Journal of biological chemistry 2004;279(29):30817-22.
2004: Nishimura Satoshi; Yasuda So-ichiro; Katoh Masayoshi; Yamada Kelly P; Yamashita Hiroshi; Saeki Yasutake; Sunagawa Kenji; Nagai Ryozo; Hisada Toshiaki; Sugiura Seiryo
Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H196-202.
2004: Jo Taisuke; Nagata Taiji; Iida Haruko; Imuta Hiroyuki; Iwasawa Kuniaki; Ma Ji; Hara Kei; Omata Masao; Nagai Ryozo; Takizawa Hajime; Nagase Takahide; Nakajima Toshiaki
Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A.
FEBS letters 2004;567(2-3):339-43.
2004: Sata Masataka; Nishimatsu Hiroaki; Osuga Jun-ichi; Tanaka Kimie; Ishizaka Nobukazu; Ishibashi Shun; Hirata Yasunobu; Nagai Ryozo
Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis.
Hypertension 2004;43(6):1214-20.
2004: Suzuki Ryo; Tobe Kazuyuki; Aoyama Masashi; Inoue Atsushi; Sakamoto Kentaro; Yamauchi Toshimasa; Kamon Junji; Kubota Naoto; Terauchi Yasuo; Yoshimatsu Hironobu; Matsuhisa Munehide; Nagasaka Shoichiro; Ogata Hitomi; Tokuyama Kumpei; Nagai Ryozo; Kadowaki Takashi
Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
The Journal of biological chemistry 2004;279(24):25039-49.
2004: Sakamoto Hironosuke; Sakamaki Tetsuo; Kanda Tsugiyasu; Tsuchiya Yoko; Sato Mahito; Sato Hiroko; Oyama Yuko; Sawada Yoshie; Tamura Jun-ichi; Nagai Ryozo; Kurabayashi Masahiko
Vascular endothelial growth factor is an autocrine growth factor for cardiac myxoma cells.
Circulation journal : official journal of the Japanese Circulation Society 2004;68(5):488-93.
2004: Yahagi Naoya; Shimano Hitoshi; Matsuzaka Takashi; Sekiya Motohiro; Najima Yuho; Okazaki Sachiko; Okazaki Hiroaki; Tamura Yoshiaki; Iizuka Yoko; Inoue Noriyuki; Nakagawa Yoshimi; Takeuchi Yoshinori; Ohashi Ken; Harada Kenji; Gotoda Takanari; Nagai Ryozo; Kadowaki Takashi; Ishibashi Shun; Osuga Jun-ichi; Yamada Nobuhiro
p53 involvement in the pathogenesis of fatty liver disease.
The Journal of biological chemistry 2004;279(20):20571-5.
2004: Seko Yoshinori; Fukuda Shuichi; Nagai Ryozo
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy.
Clinical science (London, England : 1979) 2004;106(5):439-42.
2004: Yokoyama Ikuo; Inoue Yusuke; Moritan Toshiyuki; Ohtomo Kuni; Nagai Ryozo
Impaired myocardial vasodilatation during hyperaemic stress is improved by simvastatin but not by pravastatin in patients with hypercholesterolaemia.
European heart journal 2004;25(8):671-9.
2004: Seko Yoshinori; Fujimura Tsutomu; Taka Hikari; Mineki Reiko; Murayama Kimie; Nagai Ryozo
Hypoxia followed by reoxygenation induces secretion of cyclophilin A from cultured rat cardiac myocytes.
Biochemical and biophysical research communications 2004;317(1):162-8.
2004: Niu Pei; Shindo Takayuki; Iwata Hiroshi; Iimuro Satoshi; Takeda Norifumi; Zhang Yuelan; Ebihara Aya; Suematsu Yoshihiro; Kangawa Kenji; Hirata Yasunobu; Nagai Ryozo
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.
Circulation 2004;109(14):1789-94.
2004: Sekiya Motohiro; Osuga Jun-ichi; Okazaki Hiroaki; Yahagi Naoya; Harada Kenji; Shen Wen-Jun; Tamura Yoshiaki; Tomita Sachiko; Iizuka Yoko; Ohashi Ken; Okazaki Mitsuyo; Sata Masataka; Nagai Ryozo; Fujita Toshiro; Shimano Hitoshi; Kraemer Fredric B; Yamada Nobuhiro; Ishibashi Shun
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
The Journal of biological chemistry 2004;279(15):15084-90.
2004: Saito Yuichiro; Kurabayashi Masahiko; Nakamura Tetsuya; Morita Hiroyuki; Nagai Ryozo
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():211-5.
2004: Saito Yuichiro; Nakamura Tetsuya; Nagai Ryozo
[Klotho gene and hypertension]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():112-5.
2004: Hayashi Doubun; Imai Yasushi; Morita Hiroyuki; Fujita Hideo; Monzen Koshiro; Harada Tomohiro; Nojiri Takefumi; Yamazaki Tadashi; Yamazaki Tsutomu; Nagai Ryozo
Development of a pioneering clinical support system utilizing information technology.
Japanese heart journal 2004;45(2):315-24.
2004: Satonaka Hiroshi; Suzuki Etsu; Nishimatsu Hiroaki; Oba Shigeyoshi; Takeda Ryo; Goto Atsuo; Omata Masao; Fujita Toshiro; Nagai Ryozo; Hirata Yasunobu
Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation.
Circulation research 2004;94(5):693-700.
2004: Sonoda Makoto; Yonekura Katsunori; Yokoyama Ikuo; Takenaka Katsu; Nagai Ryozo; Aoyagi Teruhiko
Common carotid intima-media thickness is correlated with myocardial flow reserve in patients with coronary artery disease: a useful non-invasive indicator of coronary atherosclerosis.
International journal of cardiology 2004;93(2-3):131-6.
2004: Kasai Hiroki; Yao Atsushi; Oyama Tomomi; Hasegawa Hiroshi; Akazawa Hiroshi; Toko Haruhiro; Nagai Toshio; Kinugawa Koichiro; Kohmoto Osami; Maruyama Kei; Takahashi Toshiyuki; Nagai Ryozo; Miyawaki Atsushi; Komuro Issei
Direct measurement of Ca2+ concentration in the SR of living cardiac myocytes.
Biochemical and biophysical research communications 2004;314(4):1014-20.
2004: Kawanami Daiji; Maemura Koji; Takeda Norihiko; Harada Tomohiro; Nojiri Takefumi; Imai Yasushi; Manabe Ichiro; Utsunomiya Kazunori; Nagai Ryozo
Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions.
Biochemical and biophysical research communications 2004;314(2):415-9.
2004: Hiroi Yukio; Fujiu Katsuhito; Komatsu Shuhei; Sonoda Makoto; Sakomura Yasunari; Imai Yasushi; Oishi Yumi; Nakamura Fumitaka; Ajiki Kohsuke; Hayami Noriyuki; Murakawa Yuji; Ohno Minoru; Hirata Yasunobu; Ohtomo Kuni; Nagai Ryozo
Carvedilol therapy improved left ventricular function in a patient with arrhythmogenic right ventricular cardiomyopathy.
Japanese heart journal 2004;45(1):169-77.
2004: Seko Yoshinori; Sugishita Kazuyuki; Sato Osamu; Takagi Atsuhiko; Tada Yusuke; Matsuo Hiroshi; Yagita Hideo; Okumura Ko; Nagai Ryozo
Expression of costimulatory molecules (4-1BBL and Fas) and major histocompatibility class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis.
Journal of vascular research 2004;41(1):84-90.
2004: Saito Yuichiro; Kurabayashi Masahiko; Nagai Ryozo
[klotho gene]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(1):65-70.
2004: Aizawa Kenichi; Suzuki Toru; Kada Nanae; Ishihara Atsushi; Kawai-Kowase Keiko; Matsumura Takayoshi; Sasaki Kana; Munemasa Yoshiko; Manabe Ichiro; Kurabayashi Masahiko; Collins Tucker; Nagai Ryozo
Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.
The Journal of biological chemistry 2004;279(1):70-6.
2004: Ishizaka Nobukazu; Saito Kan; Noiri Eisei; Sata Masataka; Mori Ichiro; Ohno Minoru; Nagai Ryozo
Iron dextran causes renal iron deposition but not renal dysfunction in angiotensin II-treated and untreated rats.
Nephron. Physiology 2004;98(4):p107-13.
2003: Yamauchi Toshimasa; Hara Kazuo; Kubota Naoto; Terauchi Yasuo; Tobe Kazuyuki; Froguel Philippe; Nagai Ryozo; Kadowaki Takashi
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(4):243-54.
2003: Nojiri Takefumi; Morita Hiroyuki; Imai Yasushi; Maemura Koji; Ohno Minoru; Ogasawara Ken; Aizawa Tadanori; Saito Akira; Hayashi Doubun; Hirata Yasunobu; Sugiyama Takao; Yamazaki Tsutomu; Nagai Ryozo
Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarction in Japanese.
International journal of cardiology 2003;92(2-3):181-6.
2003: Yamashita Hiroshi; Sugiura Seiryo; Fujita Hideo; Yasuda So ichiro; Nagai Ryozo; Saeki Yasutake; Sunagawa Kenji; Sugi Haruo
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Cardiovascular research 2003;60(3):580-8.
2003: Sekiya Motohiro; Yahagi Naoya; Matsuzaka Takashi; Najima Yuho; Nakakuki Masanori; Nagai Ryozo; Ishibashi Shun; Osuga Jun-ichi; Yamada Nobuhiro; Shimano Hitoshi
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
Hepatology (Baltimore, Md.) 2003;38(6):1529-39.
2003: Miyamoto Saku; Suzuki Toru; Muto Shinsuke; Aizawa Kenichi; Kimura Akatsuki; Mizuno Yoshiko; Nagino Tomoko; Imai Yasushi; Adachi Naruhiko; Horikoshi Masami; Nagai Ryozo
Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
Molecular and cellular biology 2003;23(23):8528-41.
2003: Nakajima Toshiaki; Ma Ji; Iida Haruko; Iwasawa Kuniaki; Jo Taisuke; Omata Masao; Nagai Ryozo
Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells.
Japanese heart journal 2003;44(6):963-78.
2003: Kadowaki Takashi; Hara Kazuo; Yamauchi Toshimasa; Terauchi Yasuo; Tobe Kazuyuki; Nagai Ryozo
Molecular mechanism of insulin resistance and obesity.
Experimental biology and medicine (Maywood, N.J.) 2003;228(10):1111-7.
2003: Natori Takeshi; Sata Masataka; Washida Miwa; Hirata Yasunobu; Nagai Ryozo; Makuuchi Masatoshi
Nicotine enhances neovascularization and promotes tumor growth.
Molecules and cells 2003;16(2):143-6.
2003: Yokoyama Ikuo; Inoue Yusuke; Moritan Toshiyuki; Ohtomo Kuni; Nagai Ryozo
Simple quantification of skeletal muscle glucose utilization by static 18F-FDG PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(10):1592-8.
2003: Fukino Keiko; Sata Masataka; Seko Yoshinori; Hirata Yasunobu; Nagai Ryozo
Genetic background influences therapeutic effectiveness of VEGF.
Biochemical and biophysical research communications 2003;310(1):143-7.
2003: Hara Kazuo; Yamauchi Toshimasa; Kubota Naoto; Tobe Kazuyuki; Yamazaki Tsutomu; Nagai Ryozo; Kadowaki Takashi
[The role of PPARgamma in the onset of type 2 diabetes]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(4):317-24.
2003: Tanaka Kimie; Sata Masataka; Hirata Yasunobu; Nagai Ryozo
Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries.
Circulation research 2003;93(8):783-90.
2003: Waki Hironori; Yamauchi Toshimasa; Kamon Junji; Ito Yusuke; Uchida Shoko; Kita Shunbun; Hara Kazuo; Hada Yusuke; Vasseur Francis; Froguel Philippe; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.
The Journal of biological chemistry 2003;278(41):40352-63.
2003: Suzuki Ryo; Tobe Kazuyuki; Terauchi Yasuo; Komeda Kajuro; Kubota Naoto; Eto Kazuhiro; Yamauchi Toshimasa; Azuma Kousuke; Kaneto Hideaki; Taguchi Takashi; Koga Teiichiro; German Michael S; Watada Hirotaka; Kawamori Ryuzo; Wright Christopher V E; Kajimoto Yoshitaka; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
The Journal of biological chemistry 2003;278(44):43691-8.
2003: Niu Pei; Shindo Takayuki; Iwata Hiroshi; Ebihara Aya; Suematsu Yoshihiro; Zhang Yuelan; Takeda Norifumi; Iimuro Satoshi; Hirata Yasunobu; Nagai Ryozo
Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(9):731-6.
2003: Saito Kan; Ishizaka Nobukazu; Mitani Haruo; Ohno Minoru; Nagai Ryozo
Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat.
FEBS letters 2003;551(1-3):58-62.
2003: Sata Masataka; Tanaka Kimie; Ishizaka Nobukazu; Hirata Yasunobu; Nagai Ryozo
Absence of p53 leads to accelerated neointimal hyperplasia after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(9):1548-52.
2003: Harada Tomohiro; Nakajima Toshiaki; Kobayakawa Naoshi; Sugiura Seiryo; Nagai Ryozo
Slowly developing heart failure associated with hormonal disorder. Late-stage acromegalic cardiomyopathy.
Journal of cardiology 2003;42(2):95-8.
2003: Saiura Akio; Sata Masataka; Washida Miwa; Sugawara Yasuhiko; Hirata Yasunobu; Nagai Ryozo; Makuuchi Masatoshi
Little evidence for cell fusion between recipient and donor-derived cells.
The Journal of surgical research 2003;113(2):222-7.
2003: Suzuki Toru; Muto Shinsuke; Miyamoto Saku; Aizawa Kenichi; Horikoshi Masami; Nagai Ryozo
Functional interaction of the DNA-binding transcription factor Sp1 through its DNA-binding domain with the histone chaperone TAF-I.
The Journal of biological chemistry 2003;278(31):28758-64.
2003: Yasuda So-ichiro; Sugiura Seiryo; Yamashita Hiroshi; Nishimura Satoshi; Saeki Yasutake; Momomura Shin-ichi; Katoh Kaoru; Nagai Ryozo; Sugi Haruo
Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2003;285(2):H470-5.
2003: Harada Tomohiro; Imai Yasushi; Nojiri Takefumi; Morita Hiroyuki; Hayashi Doubun; Maemura Koji; Fukino Keiko; Kawanami Daiji; Nishimura Go; Tsushima Kensuke; Monzen Koshiro; Yamazaki Tadashi; Mitsuyama Satoshi; Shintani Takahiko; Watanabe Narimasa; Seto Kumiko; Sugiyama Takao; Nakamura Fumitaka; Ohno Minoru; Hirata Yasunobu; Yamazaki Tsutomu; Nagai Ryozo
A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene (ABCA1) alters high density lipoprotein cholesterol level in Japanese population.
Atherosclerosis 2003;169(1):105-12.
2003: Yahagi Naoya; Shimano Hitoshi; Matsuzaka Takashi; Najima Yuho; Sekiya Motohiro; Nakagawa Yoshimi; Ide Tomohiro; Tomita Sachiko; Okazaki Hiroaki; Tamura Yoshiaki; Iizuka Yoko; Ohashi Ken; Gotoda Takanari; Nagai Ryozo; Kimura Satoshi; Ishibashi Shun; Osuga Jun-Ichi; Yamada Nobuhiro
p53 Activation in adipocytes of obese mice.
The Journal of biological chemistry 2003;278(28):25395-400.
2003: Ogata Toshiro; Kurabayashi Masahiko; Maeno Toshitaka; Sekiguchi Ken-ichi; Hoshino Yo-ichi; Ishikawa Susumu; Takei Hiroyuki; Nagai Ryozo; Morishita Yasuo
Angiogenesis inhibitor TNP-470 (AGM-1470) suppresses vascular smooth muscle cell proliferation after balloon injury in rats.
The Journal of surgical research 2003;112(2):117-21.
2003: Yamauchi Toshimasa; Kamon Junji; Ito Yusuke; Tsuchida Atsushi; Yokomizo Takehiko; Kita Shunbun; Sugiyama Takuya; Miyagishi Makoto; Hara Kazuo; Tsunoda Masaki; Murakami Koji; Ohteki Toshiaki; Uchida Shoko; Takekawa Sato; Waki Hironori; Tsuno Nelson H; Shibata Yoichi; Terauchi Yasuo; Froguel Philippe; Tobe Kazuyuki; Koyasu Shigeo; Taira Kazunari; Kitamura Toshio; Shimizu Takao; Nagai Ryozo; Kadowaki Takashi
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Abe Minami; Sata Masataka; Nishimatsu Hiroaki; Nagata Daisuke; Suzuki Etsu; Terauchi Yasuo; Kadowaki Takashi; Minamino Naoto; Kangawa Kenji; Matsuo Hisayuki; Hirata Yasunobu; Nagai Ryozo
Adrenomedullin augments collateral development in response to acute ischemia.
Biochemical and biophysical research communications 2003;306(1):10-5.
2003: Nagai Toshio; Tanaka-Ishikawa Mariko; Aikawa Ryuichi; Ishihara Hisamitsu; Zhu Weidung; Yazaki Yoshio; Nagai Ryozo; Komuro Issei
Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes.
Biochemical and biophysical research communications 2003;305(4):806-10.
2003: Harada Tomohiro; Morita Hiroyuki; Imai Yasushi; Hayashi Doubun; Takeda Norihiko; Maemura Koji; Yazaki Yoshio; Nagai Ryozo
Deficiency of protein S-mediated familial venous thrombophilia--a case report.
Angiology 2003;54(3):377-81.
2003: Suzuki Toru; Nishida Masamichi; Futami Satoru; Fukino Keiko; Amaki Toshihiro; Aizawa Kenichi; Chiba Shigeru; Hirai Hisamaru; Maekawa Kazuhiko; Nagai Ryozo
Neoendothelialization after peripheral blood stem cell transplantation in humans: a case report of a Tokaimura nuclear accident victim.
Cardiovascular research 2003;58(2):487-92.
2003: Kinugawa Koichiro; Takahashi Toshiyuki; Nagai Ryozo
[Treatment for diastolic failure]
Nippon rinsho. Japanese journal of clinical medicine 2003;61(5):857-61.
2003: Fukushima Yasushi; Shindo Takayuki; Anai Motonobu; Saitoh Toshihito; Wang Yuhui; Fujishiro Midori; Ohashi Yoshio; Ogihara Takehide; Inukai Kouichi; Ono Hiraku; Sakoda Hideyuki; Kurihara Yukiko; Honda Miho; Shojima Nobuhiro; Fukushima Harumi; Haraikawa-Onishi Yukiko; Katagiri Hideki; Shimizu Yasuhito; Ichinose Masao; Ishikawa Takashi; Omata Masao; Nagai Ryozo; Kurihara Hiroki; Asano Tomoichiro
Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.
European journal of pharmacology 2003;468(1):47-58.
2003: Manabe Ichiro; Nagai Ryozo
Regulation of smooth muscle phenotype.
Current atherosclerosis reports 2003;5(3):214-22.
2003: Imai Yasushi; Nagai Ryozo
[New biochemical and genetic risk factors for coronary artery diseases]
Nippon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():775-80.
2003: Kada Nanae; Nishimura Hiroshi; Nagai Ryozo
[Biochemical diagnosis, molecular genetics method]
Nippon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():418-24.
2003: Terauchi Yasuo; Matsui Junji; Suzuki Ryo; Kubota Naoto; Komeda Kajuro; Aizawa Shinichi; Eto Kazuhiro; Kimura Satoshi; Nagai Ryozo; Tobe Kazuyuki; Lienhard Gustav E; Kadowaki Takashi
Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
The Journal of biological chemistry 2003;278(16):14284-90.
2003: Tamura Yoshiaki; Adachi Hideki; Osuga Jun-ichi; Ohashi Ken; Yahagi Naoya; Sekiya Motohiro; Okazaki Hiroaki; Tomita Sachiko; Iizuka Yoko; Shimano Hitoshi; Nagai Ryozo; Kimura Satoshi; Tsujimoto Masafumi; Ishibashi Shun
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
The Journal of biological chemistry 2003;278(15):12613-7.
2003: Nagai Ryozo
[Cardiovascular research in the era of genome medicine and EBM]
Rinsho byori. The Japanese journal of clinical pathology 2003;51(3):208-13.
2003: Ma Ji; Nakajima Toshiaki; Iida Haruko; Iwasawa Kuniaki; Terasawa Kuniko; Oonuma Hitoshi; Jo Taisuke; Morita Toshihiro; Imuta Hiroyuki; Suzuki Jun ichi; Hirose Ken; Okuda Yukichi; Yamada Nobuhiko; Nagai Ryozo; Omata Masao
Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells.
European journal of pharmacology 2003;464(2-3):79-86.
2003: Nishimatsu Hiroaki; Hirata Yasunobu; Shindo Takayuki; Kurihara Hiroki; Suzuki Etsu; Sata Masataka; Satonaka Hiroshi; Takeda Ryo; Nagata Daisuke; Kakoki Masao; Hayakawa Hiroshi; Kangawa Kenji; Matsuo Hisayuki; Kitamura Tadaichi; Nagai Ryozo
Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S79-84.
2003: Suzuki Masatoshi; Iso-o Naoyuki; Takeshita Satoshi; Tsukamoto Kazuhisa; Mori Ichiro; Sato Tomohide; Ohno Minoru; Nagai Ryozo; Ishizaka Nobukazu
Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia.
Biochemical and biophysical research communications 2003;302(1):138-43.
2003: Ishizaka Nobukazu; Ishizaka Yuko; Takahashi Eiko; Unuma Tadao; Tooda Ei-ichi; Nagai Ryozo; Togo Masako; Tsukamoto Kazuhisa; Hashimoto Hideki; Yamakado Minoru
Association between insulin resistance and carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):295-301.
2003: Hiroi Yukio; Nakao Tomoko; Tsuchiya Naoyuki; Takeda Norihiko; Maemura Koji; Nakamura Fumitaka; Ohno Minoru; Hirata Yasunobu; Nagai Ryozo
Exacerbation of Lambert-Eaton myasthenic syndrome caused by an L-type Ca2+ channel antagonist.
Japanese heart journal 2003;44(1):139-44.
2003: Murakawa Yuji; Yamashita Takeshi; Ajiki Kohsuke; Hayami Noriyuki; Omata Masao; Nagai Ryozo
Effect of cervical vagal nerve stimulation on defibrillation energy: a possible adjunct to efficient defibrillation.
Japanese heart journal 2003;44(1):91-100.
2003: Tobe Kazuyuki; Asai Shohji; Matuoka Koozi; Yamamoto Tadashi; Chida Kazuhiro; Kaburagi Yasushi; Akanuma Yasuo; Kuroki Toshio; Takenawa Tadaomi; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):29-40.
2003: Yao Atsushi; Kohmoto Osami; Oyama Tomomi; Sugishita Yasuyuki; Shimizu Tatsuya; Harada Kazumasa; Matsui Hiroshi; Komuro Issei; Nagai Ryozo; Matsuo Hiroshi; Serizawa Takashi; Maruyama Takashi; Takahashi Toshiyuki
Characteristic effects of alpha1-beta1,2-adrenergic blocking agent, carvedilol, on [Ca2+]i in ventricular myocytes compared with those of timolol and atenolol.
Circulation journal : official journal of the Japanese Circulation Society 2003;67(1):83-90.
2003: Ishizaka Yuko; Ishizaka Nobukazu; Takahashi Eiko; Unuma Tadao; Tooda Ei-ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Association between hepatitis C virus core protein and carotid atherosclerosis.
Circulation journal : official journal of the Japanese Circulation Society 2003;67(1):26-30.
2003: Yamauchi Toshimasa; Kamon Junji; Waki Hironori; Imai Yasushi; Shimozawa Nobuhiro; Hioki Kyouji; Uchida Shoko; Ito Yusuke; Takakuwa Keisuke; Matsui Junji; Takata Makoto; Eto Kazuhiro; Terauchi Yasuo; Komeda Kajuro; Tsunoda Masaki; Murakami Koji; Ohnishi Yasuyuki; Naitoh Takeshi; Yamamura Kenichi; Ueyama Yoshito; Froguel Philippe; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
The Journal of biological chemistry 2003;278(4):2461-8.
2003: Sugiura Seiryo; Yasuda So-ichiro; Yamashita Hiroshi; Kato Kaoru; Saeki Yasutake; Kaneko Hiroko; Suda Yoshihisa; Nagai Ryozo; Sugi Haruo
Measurement of force developed by a single cardiac myocyte using novel carbon fibers.
Advances in experimental medicine and biology 2003;538():381-6; discussion 386-7.
2003: Nagai Ryozo; Shindo Takayuki; Manabe Ichiro; Suzuki Toru; Kurabayashi Masahiko
KLF5/BTEB2, a Krüppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Advances in experimental medicine and biology 2003;538():57-65; discussion 66.
2003: Fukushima Yasushi; Ishikawa Takashi; Saitoh Toshihito; Tateishi Keisuke; Ogihara Takehide; Fujishiro Midori; Shojima Nobuhiro; Honda Miho; Kushiyama Akifumi; Anai Motonobu; Sakoda Hideyuki; Ono Hiraku; Onishi Yukiko; Otsuka Hiroko; Katagiri Hideki; Nagai Ryozo; Omata Masao; Asano Tomoichiro
Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells.
Digestion 2003;68(2-3):145-52.
2003: Sakamoto Hironosuke; Sakamaki Tetsuo; Kanda Tsugiyasu; Hoshino Yo-ichi; Sawada Yoshie; Sato Mahito; Sato Hiroko; Oyama Yuko; Nakano Akihiko; Takase Shin-ichi; Hasegawa Akira; Nagai Ryozo; Kurabayashi Masahiko
Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2.
Cardiology 2003;100(2):80-5.
2003: Hara Kazuo; Ohe Kazuhiko; Kadowaki Takashi; Kato Naoya; Imai Yasushi; Tokunaga Katsushi; Nagai Ryozo; Omata Masao
Establishment of a method of anonymization of DNA samples in genetic research.
Journal of human genetics 2003;48(6):327-30.
2002: Manabe Ichiro; Shindo Takayuki; Nagai Ryozo
Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy.
Circulation research 2002;91(12):1103-13.
2002: Terasawa Kuniko; Nakajima Toshiaki; Iida Haruko; Iwasawa Kuniaki; Oonuma Hitoshi; Jo Taisuke; Morita Toshihiro; Nakamura Fumitaka; Fujimori Yoshiharu; Toyo-oka Teruhiko; Nagai Ryozo
Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell: modulation by lysophosphatidylcholine.
Circulation 2002;106(24):3111-9.
2002: Monzen Koshiro; Zhu Weidong; Kasai Hiroki; Hiroi Yukio; Hosoda Toru; Akazawa Hiroshi; Zou Yunzeng; Hayashi Doubun; Yamazaki Tsutomu; Nagai Ryozo; Komuro Issei
Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes.
Biochemical and biophysical research communications 2002;298(4):493-500.
2002: Aoki-Nagase Tomoko; Nagase Takahide; Oh-Hashi Yoshio; Shindo Takayuki; Kurihara Yukiko; Yamaguchi Yasuhiro; Yamamoto Hiroshi; Tomita Tetsuji; Ohga Eijiro; Nagai Ryozo; Kurihara Hiroki; Ouchi Yasuyoshi
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L963-70.
2002: Yamauchi T; Kamon J; Minokoshi Y; Ito Y; Waki H; Uchida S; Yamashita S; Noda M; Kita S; Ueki K; Eto K; Akanuma Y; Froguel P; Foufelle F; Ferre P; Carling D; Kimura S; Nagai R; Kahn B B; Kadowaki T
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nature medicine 2002;8(11):1288-95.
2002: Ishizaka Nobukazu; Mitani Haruo; Nagai Ryozo
[Angiotensin II regulates klotho gene expression]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(10):1935-9.
2002: Kaneda Hideaki; Ohno Minoru; Taguchi Junichi; Togo Masako; Hashimoto Hideki; Ogasawara Ken; Aizawa Tadanori; Ishizaka Nobukazu; Nagai Ryozo
Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1680-5.
2002: Natori Takeshi; Sata Masataka; Washida Miwa; Hirata Yasunobu; Nagai Ryozo; Makuuchi Masatoshi
G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells.
Biochemical and biophysical research communications 2002;297(4):1058-61.
2002: Ishizaka Nobukazu; Saito Kan; Mitani Haruo; Yamazaki Ieharu; Sata Masataka; Usui Shin-ichi; Mori Ichiro; Ohno Minoru; Nagai Ryozo
Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation.
Circulation 2002;106(14):1840-6.
2002: Suzuki Etsu; Nishimatsu Hiroaki; Nagata Daisuke; Satonaka Hiroshi; Goto Atsuo; Omata Masao; Fujita Toshiro; Nagai Ryozo; Hirata Yasunobu
Constitutive activation of proto-oncogen protein p21 induces cell cycle arrest in the G1 phase in contact-inhibited vascular endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(5):773-8.
2002: Kamemori Mariko; Ohyama Yoshio; Kurabayashi Masahiko; Takahashi Katumasa; Nagai Ryozo; Furuya Nobuhiko
Expression of Klotho protein in the inner ear.
Hearing research 2002;171(1-2):103-110.
2002: Monzen Koshiro; Nagai Ryozo; Komuro Issei
A role for bone morphogenetic protein signaling in cardiomyocyte differentiation.
Trends in cardiovascular medicine 2002;12(6):263-9.
2002: Imai Yasushi; Shindo Takayuki; Maemura Koji; Sata Masataka; Saito Yuichiro; Kurihara Yukiko; Akishita Masahiro; Osuga Junichi; Ishibashi Shun; Tobe Kazuyuki; Morita Hiroyuki; Oh-hashi Yoshio; Suzuki Toru; Maekawa Hiromitsu; Kangawa Kenji; Minamino Naoto; Yazaki Yoshio; Nagai Ryozo; Kurihara Hiroki
Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1310-5.
2002: Sata Masataka; Takahashi Akihiro; Tanaka Kimie; Washida Miwa; Ishizaka Nobukazu; Ako Junya; Yoshizumi Masao; Ouchi Yasuyoshi; Taniguchi Takahiro; Hirata Yasunobu; Yokoyama Mitsuhiro; Nagai Ryozo; Walsh Kenneth
Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1305-9.
2002: Shindo Takayuki; Manabe Ichiro; Fukushima Yasushi; Tobe Kazuyuki; Aizawa Kenichi; Miyamoto Saku; Kawai-Kowase Keiko; Moriyama Nobuo; Imai Yasushi; Kawakami Hayato; Nishimatsu Hiroaki; Ishikawa Takashi; Suzuki Toru; Morita Hiroyuki; Maemura Koji; Sata Masataka; Hirata Yasunobu; Komukai Masayuki; Kagechika Hiroyuki; Kadowaki Takashi; Kurabayashi Masahiko; Nagai Ryozo
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature medicine 2002;8(8):856-63.
2002: Okazaki Hiroaki; Osuga Jun-ichi; Tsukamoto Kazuhisa; Isoo Naoyuki; Kitamine Tetsuya; Tamura Yoshiaki; Tomita Sachiko; Sekiya Motohiro; Yahagi Naoya; Iizuka Yoko; Ohashi Ken; Harada Kenji; Gotoda Takanari; Shimano Hitoshi; Kimura Satoshi; Nagai Ryozo; Yamada Nobuhiro; Ishibashi Shun
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
The Journal of biological chemistry 2002;277(35):31893-9.
2002: Sata Masataka; Hirata Yasunobu; Nagai Ryozo
Role of Fas/Fas ligand interaction in ischemia-induced collateral vessel growth.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(4):577-82.
2002: Suzuki Toru; Kohno Hiroaki; Hasegawa Akira; Toshima Shunichi; Amaki Toshihiro; Kurabayashi Masahiko; Nagai Ryozo; Suzuki Toru; Amaki Toshihiro; Nagai Ryozo; Hasegawa Akira; Toshima Shunichi; Kurabayashi Masa-hiko; Shimada Kazuyuki; Nakamura Haruo; Teramoto Tamio; Yamaguchi Hiroshi; Nishiyama Shin-ichiro; Takahashi Hakuo; Michishita Ichiro; Sugano Zinpei; Konoshi Keiko;
Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary artery disease.
Clinical biochemistry 2002;35(5):347-53.
2002: Suzuki Toru; Kohno Hiroaki; Hasegawa Akira; Toshima Shunichi; Amaki Toshihiro; Kurabayashi Masahiko; Nagai Ryozo; Suzuki Toru; Amaki Toshihiro; Nagai Ryozo; Hasegawa Akira; Toshima Shunichi; Kurabayashi Masa-hiko; Shimada Kazuyuki; Nakamura Haruo; Teramoto Tamio; Yamaguchi Hiroshi; Nishiyama Shin-ichiro; Takahashi Hakuo; Michishita Ichiro; Sugano Zinpei; Konoshi Keiko;
Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary artery disease.
Clinical biochemistry 2002;35(5):347-53.
2002: Inoue Koichi; Matsuda Koichi; Itoh Makoto; Kawaguchi Hiroshi; Tomoike Hitonobu; Aoyagi Teruhiko; Nagai Ryozo; Hori Masatsugu; Nakamura Yusuke; Tanaka Toshihiro
Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5.
Human molecular genetics 2002;11(15):1775-84.
2002: Muto Satoru; Aiba Atsu; Saito Yuichirou; Nakao Kazuki; Nakamura Kenji; Tomita Kyoichi; Kitamura Tadaichi; Kurabayashi Masahiko; Nagai Ryozo; Higashihara Eiji; Harris Peter C; Katsuki Motoya; Horie Shigeo
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Human molecular genetics 2002;11(15):1731-42.
2002: Kubota Naoto; Terauchi Yasuo; Yamauchi Toshimasa; Kubota Tetsuya; Moroi Masao; Matsui Junji; Eto Kazuhiro; Yamashita Tokuyuki; Kamon Junji; Satoh Hidemi; Yano Wataru; Froguel Philippe; Nagai Ryozo; Kimura Satoshi; Kadowaki Takashi; Noda Tetsuo
Disruption of adiponectin causes insulin resistance and neointimal formation.
The Journal of biological chemistry 2002;277(29):25863-6.
2002: Toko Haruhiro; Zhu Weidong; Takimoto Eiki; Shiojima Ichiro; Hiroi Yukio; Zou Yunzeng; Oka Toru; Akazawa Hiroshi; Mizukami Miho; Sakamoto Masaya; Terasaki Fumio; Kitaura Yasushi; Takano Hiroyuki; Nagai Toshio; Nagai Ryozo; Komuro Issei
Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart.
The Journal of biological chemistry 2002;277(27):24735-43.
2002: Nakamura Tetsuya; Saito Yuichiro; Ohyama Yoshio; Masuda Hiroaki; Sumino Hiroyuki; Kuro-o Makoto; Nabeshima Youichi; Nagai Ryozo; Kurabayashi Masahiko
Production of nitric oxide, but not prostacyclin, is reduced in klotho mice.
Japanese journal of pharmacology 2002;89(2):149-56.
2002: Ikeda Yuichi; Hiroi Yukio; Hosoda Toru; Utsunomiya Toshinori; Matsuo Shuzo; Ito Tsuyoshi; Inoue Jun-ichi; Sumiyoshi Tetsuya; Takano Hiroyuki; Nagai Ryozo; Komuro Issei
Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(6):561-3.
2002: Tomaru Ki Kou-ichi; Arai Masashi; Yokoyama Tomoyuki; Aihara Yasushi; Sekiguchi Ki Ken-ichi; Tanaka Toru; Nagai Ryozo; Kurabayashi Masahiko
Transcriptional activation of the BNP gene by lipopolysaccharide is mediated through GATA elements in neonatal rat cardiac myocytes.
Journal of molecular and cellular cardiology 2002;34(6):649-59.
2002: Aikawa Ryuichi; Nitta-Komatsubara Yuko; Kudoh Sumiyo; Takano Hiroyuki; Nagai Toshio; Yazaki Yoshio; Nagai Ryozo; Komuro Issei
Reactive oxygen species induce cardiomyocyte apoptosis partly through TNF-alpha.
Cytokine 2002;18(4):179-83.
2002: Seko Yoshinori; Ishiyama Shigeru; Nishikawa Toshiro; Kasajima Takeshi; Hiroe Michiaki; Suzuki Shin; Ishiwata Sugao; Kawai Sachio; Tanaka Yuetsu; Azuma Miyuki; Kobata Tetsuji; Yagita Hideo; Okumura Ko; Nagai Ryozo
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2002;11(3):166-70.
2002: Suzuki Etsu; Nishimatsu Hiroaki; Satonaka Hiroshi; Walsh Kenneth; Goto Atsuo; Omata Masao; Fujita Toshiro; Nagai Ryozo; Hirata Yasunobu
Angiotensin II induces myocyte enhancer factor 2- and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes.
Circulation research 2002;90(9):1004-11.
2002: Yahagi Naoya; Shimano Hitoshi; Hasty Alyssa H; Matsuzaka Takashi; Ide Tomohiro; Yoshikawa Tomohiro; Amemiya-Kudo Michiyo; Tomita Sachiko; Okazaki Hiroaki; Tamura Yoshiaki; Iizuka Yoko; Ohashi Ken; Osuga Jun-Ichi; Harada Kenji; Gotoda Takanari; Nagai Ryozo; Ishibashi Shun; Yamada Nobuhiro
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
The Journal of biological chemistry 2002;277(22):19353-7.
2002: Fukino Keiko; Suzuki Toru; Saito Yuichiro; Shindo Takayuki; Amaki Toshihiro; Kurabayashi Masahiko; Nagai Ryozo
Regulation of angiogenesis by the aging suppressor gene klotho.
Biochemical and biophysical research communications 2002;293(1):332-7.
2002: Murakawa Yuji; Yamashita Takeshi; Ajiki Kohsuke; Hayami Noriyuki; Fukui Ei-Ichi; Kasaoka Yuji; Omata Masao; Nagai Ryozo
Site of the arrhythmogenic focus and cardiac vulnerability to ventricular fibrillation.
Pacing and clinical electrophysiology : PACE 2002;25(4 Pt 1):446-56.
2002: Mitani Haruo; Ishizaka Nobukazu; Aizawa Toru; Ohno Minoru; Usui Shin-ichi; Suzuki Toru; Amaki Toshihiro; Mori Ichiro; Nakamura Yasushi; Sato Misako; Nangaku Masaomi; Hirata Yasunobu; Nagai Ryozo
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage.
Hypertension 2002;39(4):838-43.
2002: Mise Naobumi; Kimura Kenjiro; Kurabayashi Masahiko; Nagai Ryozo; Okuda Toshihiro; Ohba Shigeyoshi; Suzuki Naoe; Miyashita Kazuhisa; Kamijo Atsuko; Tojo Akihiro; Goto Atsuo; Omata Masao
Angiotensin II enhances glomerular expression of a nonmuscle myosin heavy chain, SMemb, with extracellular matrix accumulation.
Nephron 2002;90(4):477-83.
2002: Seko Yoshinori; Kayagaki Nobuhiko; Seino Ken-ichiro; Yagita Hideo; Okumura Ko; Nagai Ryozo
Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3.
Journal of the American College of Cardiology 2002;39(8):1399-403.
2002: Nishimatsu Hiroaki; Hirata Yasunobu; Shindo Takayuki; Kurihara Hiroki; Kakoki Masao; Nagata Daisuke; Hayakawa Hiroshi; Satonaka Hiroshi; Sata Masataka; Tojo Akihiro; Suzuki Etsu; Kangawa Kenji; Matsuo Hisayuki; Kitamura Tadaichi; Nagai Ryozo
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene.
Circulation research 2002;90(6):657-63.
2002: Sata Masataka; Saiura Akio; Kunisato Atsushi; Tojo Akihiro; Okada Seiji; Tokuhisa Takeshi; Hirai Hisamaru; Makuuchi Masatoshi; Hirata Yasunobu; Nagai Ryozo
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis.
Nature medicine 2002;8(4):403-9.
2002: Tsuji Taeko; Suzuki Jun-ichi; Shimamoto Ryoichi; Yamazaki Tadashi; Nakajima Toshiaki; Nagai Ryozo; Komatsu Shuhei; Ohtomo Kuni; Toyo-Oka Teruhiko; Omata Masao
Vector analysis of the wall shear rate at the human aortoiliac bifurcation using cine MR velocity mapping.
AJR. American journal of roentgenology 2002;178(4):995-9.
2002: Watanabe Atai; Kanai Hiroyoshi; Arai Masashi; Sekiguchi Kenichi; Uchiyama Tsuyoshi; Nagai Ryozo; Kurabayashi Masahiko
Retinoids induce the PAI-1 gene expression through tyrosine kinase-dependent pathways in vascular smooth muscle cells.
Journal of cardiovascular pharmacology 2002;39(4):503-12.
2002: Ishizaka Nobukazu; Ishizaka Yuko; Takahashi Eiko; Tooda Ei-ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Serum calcium concentration and carotid artery plaque: a population-based study.
Journal of cardiology 2002;39(3):151-7.
2002: Takeda N; Yokoyama I; Hiroi Y; Sakata M; Harada T; Nakamura F; Murakawa Y; Nagai R
Positron emission tomography predicted recovery of complete A-V nodal dysfunction in a patient with cardiac sarcoidosis.
Circulation 2002;105(9):1144-5.
2002: Ishizaka Nobukazu; Ishizaka Yuko; Takahashi Eiko; Toda Ei Ei-ichi; Hashimoto Hideki; Ohno Minoru; Nagai Ryozo; Yamakado Minoru
Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers.
Circulation 2002;105(9):1028-30.
2002: Takimoto Eiki; Yao Atsushi; Toko Haruhiro; Takano Hiroyuki; Shimoyama Masaki; Sonoda Makoto; Wakimoto Koji; Takahashi Toshiyuki; Akazawa Hiroshi; Mizukami Miho; Nagai Toshio; Nagai Ryozo; Komuro Issei
Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):373-8.
2002: Oonuma Hitoshi; Iwasawa Kuniaki; Iida Haruko; Nagata Taiji; Imuta Hiroyuki; Morita Yutaka; Yamamoto Kazuhiko; Nagai Ryozo; Omata Masao; Nakajima Toshiaki
Inward rectifier K(+) current in human bronchial smooth muscle cells: inhibition with antisense oligonucleotides targeted to Kir2.1 mRNA.
American journal of respiratory cell and molecular biology 2002;26(3):371-9.
2002: Shindo T; Kurihara H; Maemura K; Kurihara Y; Ueda O; Suzuki H; Kuwaki T; Ju K-H; Wang Y; Ebihara A; Nishimatsu H; Moriyama N; Fukuda M; Akimoto Y; Hirano H; Morita H; Kumada M; Yazaki Y; Nagai R; Kimura K
Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.
Journal of molecular medicine (Berlin, Germany) 2002;80(2):105-16.
2002: Oyama Yuko; Akuzawa Nobuhiro; Nagai Ryozo; Kurabayashi Masahiko
PPARgamma ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells.
Circulation research 2002;90(3):348-55.
2002: Aikawa Ryuichi; Nagai Toshio; Kudoh Sumiyo; Zou Yunzeng; Tanaka Mariko; Tamura Masahito; Akazawa Hiroshi; Takano Hiroyuki; Nagai Ryozo; Komuro Issei
Integrins play a critical role in mechanical stress-induced p38 MAPK activation.
Hypertension 2002;39(2):233-8.
2002: Yamauchi Toshimasa; Oike Yuichi; Kamon Junji; Waki Hironori; Komeda Kajuro; Tsuchida Atsuko; Date Yukari; Li Meng-Xian; Miki Hiroshi; Akanuma Yasuo; Nagai Ryozo; Kimura Satoshi; Saheki Takeyori; Nakazato Masamitsu; Naitoh Takeshi; Yamamura Kenichi; Kadowaki Takashi
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.
Nature genetics 2002;30(2):221-6.
2002: Hara Kazuo; Boutin Philippe; Mori Yasumichi; Tobe Kazuyuki; Dina Christian; Yasuda Kazuki; Yamauchi Toshimasa; Otabe Shuichi; Okada Terumasa; Eto Kazuhiro; Kadowaki Hiroko; Hagura Ryoko; Akanuma Yasuo; Yazaki Yoshio; Nagai Ryozo; Taniyama Matsuo; Matsubara Koichi; Yoda Madoka; Nakano Yasuko; Tomita Motowo; Kimura Satoshi; Ito Chikako; Froguel Philippe; Kadowaki Takashi
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
Diabetes 2002;51(2):536-40.
2002: Maeno Toshitaka; Tanaka Toru; Sando Yoshichika; Suga Tatsuo; Maeno Yuri; Nakagawa Junichi; Hosono Tatsuya; Sato Mahito; Akiyama Hideo; Kishi Shoji; Nagai Ryozo; Kurabayashi Masahiko
Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells.
American journal of respiratory cell and molecular biology 2002;26(2):246-53.
2002: Zou Yunzeng; Yamazaki Tsutomu; Nakagawa Keiichi; Yamada Haruyasu; Iriguchi Norio; Toko Haruhiro; Takano Hiroyuki; Akazawa Hiroshi; Nagai Ryozo; Komuro Issei
Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(1):117-24.
2002: Harada Tomohiro; Aoyagi Teruhiko; Endo Yoko; Uno Kansei; Takenaka Katsu; Nakamura Fumitaka; Sonoda Makoto; Takahashi Toshiyuki; Yamazaki Tadashi; Hiroi Yukio; Ohno Minoru; Hirata Yasunobu; Nagai Ryozo
Effusive constrictive pericarditis due to rheumatoid arthritis revealed by pericardiocentesis with simultaneous pressure recording--a case report.
Angiology 2002;53(1):105-8.
2002: Yonekura Katsunori; Yokoyama Ikuo; Ohtake Tohru; Inoue Yusuke; Aoyagi Teruhiko; Sugiura Seiryo; Momose Toshimitsu; Otomo Kuni; Nagai Ryozo
Reduced myocardial flow reserve in anatomically normal coronary arteries due to elevated baseline myocardial blood flow in men with old myocardial infarction.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2002;9(1):62-7.
2002: Sata Masataka; Hirata Yasunobu; Nagai Ryozo
[Circulating recipient cells contribute to graft coronary arteriosclerosis]
Journal of cardiology 2002;39(1):48-9.
2002: Ishizaka Nobukazu; Ishizaka Yuko; Takahashi Eiko; Tooda Ei ichi; Hashimoto Hideki; Nagai Ryozo; Yamakado Minoru
Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening.
Lancet 2002;359(9301):133-5.
2002: Aizawa Toru; Ishizaka Nobukazu; Usui Shin-Ichi; Ohashi Noriko; Ohno Minoru; Nagai Ryozo
Angiotensin II and catecholamines increase plasma levels of 8-epi-prostaglandin F(2alpha) with different pressor dependencies in rats.
Hypertension 2002;39(1):149-54.
2002: Ishizaka Nobukazu; Aizawa Toru; Ohno Minoru; Usui Si Shin-ichi; Mori Ichiro; Tang Shiow-Shih; Ingelfinger Julie R; Kimura Satoshi; Nagai Ryozo
Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II.
Hypertension 2002;39(1):122-8.
2002: Ishizaka Nobukazu; Aizawa Toru; Yamazaki Ieharu; Usui Shin-ichi; Mori Ichiro; Kurokawa Kiyoshi; Tang Shiow-Shih; Ingelfinger Julie R; Ohno Minoru; Nagai Ryozo
Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration.
Laboratory investigation; a journal of technical methods and pathology 2002;82(1):87-96.
2002: Morita Hiroyuki; Saito Yuichiro; Kurabayashi Masahiko; Nagai Ryozo
Diet-induced mild hyperhomocysteinemia and increased salt intake diminish vascular endothelial function in a synergistic manner.
Journal of hypertension 2002;20(1):55-62.
2002: Sato Mahito; Tanaka Toru; Maeno Toshitaka; Sando Yoshichika; Suga Tatsuo; Maeno Yuri; Sato Hiroko; Nagai Ryozo; Kurabayashi Masahiko
Inducible expression of endothelial PAS domain protein-1 by hypoxia in human lung adenocarcinoma A549 cells. Role of Src family kinases-dependent pathway.
American journal of respiratory cell and molecular biology 2002;26(1):127-34.
2002: Iwasa Hiroyasu; Kurabayashi Masahiko; Nagai Ryozo; Nakamura Yusuke; Tanaka Toshihiro
Twenty single-nucleotide polymorphisms in four genes encoding cardiac ion channels.
Journal of human genetics 2002;47(4):208-12.
2001: Kaji Y; Amano S; Usui T; Suzuki K; Tanaka S; Oshika T; Nagai R; Horiuchi S
Advanced glycation end products in Descemet's membrane and their effect on corneal endothelial cell.
Current eye research 2001;23(6):469-77.
2001: Nagai R; Suzuki T; Aizawa K; Miyamoto S; Amaki T; Kawai-Kowase K; Sekiguchi K I; Kurabayashi M
Phenotypic modulation of vascular smooth muscle cells: dissection of transcriptional regulatory mechanisms.
Annals of the New York Academy of Sciences 2001;947():56-66; discussion 66-7.
2001: Imai Y; Shiindo T; Maemura K; Kurihara Y; Nagai R; Kurihara H
Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.
Annals of the New York Academy of Sciences 2001;947():26-33; discussion 33-4.
2001: Saiura A; Sata M; Hirata Y; Nagai R; Makuuchi M
Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation.
European journal of pharmacology 2001;433(2-3):163-8.
2001: Seko Y; Takahashi N; Oshima H; Shimozato O; Akiba H; Takeda K; Kobata T; Yagita H; Okumura K; Azuma M; Nagai R
Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3.
The Journal of pathology 2001;195(5):593-603.
2001: Aikawa R; Nagai T; Tanaka M; Zou Y; Ishihara T; Takano H; Hasegawa H; Akazawa H; Mizukami M; Nagai R; Komuro I
Reactive oxygen species in mechanical stress-induced cardiac hypertrophy.
Biochemical and biophysical research communications 2001;289(4):901-7.
2001: Yamagishi T; Saito Y; Nakamura T; Takeda S; Kanai H; Sumino H; Kuro-o M; Nabeshima Y; Kurabayashi M; Nagai R
Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(6):705-9.
2001: Nishimatsu H; Hirata Y; Hayakawa H; Nagata D; Satonaka H; Suzuki E; Horie S; Takeuchi T; Ohta N; Homma Y; Minowada S; Nagai R; Kawabe K; Kitamura T
Effects of intracavernous administration of adrenomedullin on erectile function in rats.
Peptides 2001;22(11):1913-8.
2001: Oh-hashi Y; Shindo T; Kurihara Y; Imai T; Wang Y; Morita H; Imai Y; Kayaba Y; Nishimatsu H; Suematsu Y; Hirata Y; Yazaki Y; Nagai R; Kuwaki T; Kurihara H
Elevated sympathetic nervous activity in mice deficient in alphaCGRP.
Circulation research 2001;89(11):983-90.
2001: Zou Y; Nagai R; Yamazaki T
Urotensin II induces hypertrophic responses in cultured cardiomyocytes from neonatal rats.
FEBS letters 2001;508(1):57-60.
2001: Sata M; Sugiura S; Yoshizumi M; Ouchi Y; Hirata Y; Nagai R
Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the Fas-death pathway.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1733-7.
2001: Sata M; Nishimatsu H; Suzuki E; Sugiura S; Yoshizumi M; Ouchi Y; Hirata Y; Nagai R
Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(13):2530-2.
2001: Yamauchi T; Kamon J; Waki H; Murakami K; Motojima K; Komeda K; Ide T; Kubota N; Terauchi Y; Tobe K; Miki H; Tsuchida A; Akanuma Y; Nagai R; Kimura S; Kadowaki T
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.
The Journal of biological chemistry 2001;276(44):41245-54.
2001: Takahashi T; Sugishita Y; Kinugawa K; Shimizu T; Yao A; Harada K; Matsui H; Nagai R
Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes.
Molecular and cellular biochemistry 2001;226(1-2):57-65.
2001: Harada K; Shimizu T; Sugishita Y; Yao A; Suzuki J; Takenaka K; Hirata Y; Nagai R; Takahashi T
Hypertrophic cardiomyopathy with midventricular obstruction and apical aneurysm: a case report.
Japanese circulation journal 2001;65(10):915-9.
2001: Shindo T; Kurihara Y; Nishimatsu H; Moriyama N; Kakoki M; Wang Y; Imai Y; Ebihara A; Kuwaki T; Ju K H; Minamino N; Kangawa K; Ishikawa T; Fukuda M; Akimoto Y; Kawakami H; Imai T; Morita H; Yazaki Y; Nagai R; Hirata Y; Kurihara H
Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Circulation 2001;104(16):1964-71.
2001: Yamauchi T; Waki H; Kamon J; Murakami K; Motojima K; Komeda K; Miki H; Kubota N; Terauchi Y; Tsuchida A; Tsuboyama-Kasaoka N; Yamauchi N; Ide T; Hori W; Kato S; Fukayama M; Akanuma Y; Ezaki O; Itai A; Nagai R; Kimura S; Tobe K; Kagechika H; Shudo K; Kadowaki T
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
The Journal of clinical investigation 2001;108(7):1001-13.
2001: Tobe K; Suzuki R; Aoyama M; Yamauchi T; Kamon J; Kubota N; Terauchi Y; Matsui J; Akanuma Y; Kimura S; Tanaka J; Abe M; Ohsumi J; Nagai R; Kadowaki T
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
The Journal of biological chemistry 2001;276(42):38337-40.
2001: Hasty A H; Shimano H; Osuga J; Namatame I; Takahashi A; Yahagi N; Perrey S; Iizuka Y; Tamura Y; Amemiya-Kudo M; Yoshikawa T; Okazaki H; Ohashi K; Harada K; Matsuzaka T; Sone H; Gotoda T; Nagai R; Ishibashi S; Yamada N
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
The Journal of biological chemistry 2001;276(40):37402-8.
2001: Harada T; Nakamura F; Ikeda Y; Usui S; Tsuchiya N; Ohno M; Hirata Y; Nagai R
Successful catheter intervention for acute coronary syndrome in a patient with antiphospholipid syndrome.
Japanese heart journal 2001;42(5):627-31.
2001: Yasuda S I; Sugiura S; Kobayakawa N; Fujita H; Yamashita H; Katoh K; Saeki Y; Kaneko H; Suda Y; Nagai R; Sugi H
A novel method to study contraction characteristics of a single cardiac myocyte using carbon fibers.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1442-6.
2001: Manabe N; Kawaguchi H; Chikuda H; Miyaura C; Inada M; Nagai R; Nabeshima Y; Nakamura K; Sinclair A M; Scheuermann R H; Kuro-o M
Connection between B lymphocyte and osteoclast differentiation pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2625-31.
2001: Hosoda T; Monzen K; Hiroi Y; Oka T; Takimoto E; Yazaki Y; Nagai R; Komuro I
A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes.
The Journal of biological chemistry 2001;276(38):35978-89.
2001: Yamauchi T; Kamon J; Waki H; Terauchi Y; Kubota N; Hara K; Mori Y; Ide T; Murakami K; Tsuboyama-Kasaoka N; Ezaki O; Akanuma Y; Gavrilova O; Vinson C; Reitman M L; Kagechika H; Shudo K; Yoda M; Nakano Y; Tobe K; Nagai R; Kimura S; Tomita M; Froguel P; Kadowaki T
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nature medicine 2001;7(8):941-6.
2001: Hangaishi M; Nakajima H; Taguchi J; Igarashi R; Hoshino J; Kurokawa K; Kimura S; Nagai R; Ohno M
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo.
Biochemical and biophysical research communications 2001;285(5):1220-5.
2001: Hirata Y; Matsumoto A; Aoyagi T; Yamaoki K; Komuro I; Suzuki T; Ashida T; Sugiyama T; Hada Y; Kuwajima I; Nishinaga M; Akioka H; Nakajima O; Nagai R; Yazaki Y
Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload.
Cardiovascular research 2001;51(3):585-91.
2001: Kawamura T; Sando Y; Tajima S; Hosono T; Sato M; Maeno Y; Maeno T; Suga T; Kurabayashi M; Nagai R
Pulmonary intravascular lymphoma complicated with Pneumocystis carinii pneumonia: a case report.
Japanese journal of clinical oncology 2001;31(7):333-6.
2001: Hiroi Y; Hiroi J; Kudoh S; Yazaki Y; Nagai R; Komuro I
Two distinct mechanisms of angiotensin II-induced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(4):385-94.
2001: Nakajima H; Hangaishi M; Ishizaka N; Taguchi J; Igarashi R; Mizushima Y; Nagai R; Ohno M
Lecithinized copper, zinc-superoxide dismutase ameliorates ischemia-induced myocardial damage.
Life sciences 2001;69(8):935-44.
2001: Yokoyama I; Yonekura K; Inoue Y; Ohtomo K; Nagai R
Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2001;8(4):445-51.
2001: Harada K; Sugishita Y; Shimizu T; Yao A; Matsui H; Kohmoto O; Serizawa T; Nagai R; Takahashi T
Left ventricular relaxation abnormality is detectable by analysis of the relaxation time constant in patients with atrial fibrillation.
Japanese circulation journal 2001;65(7):610-6.
2001: Yokoyama I; Yonekura K; Moritan T; Tateno M; Momose T; Ohtomo K; Inoue Y; Nagai R
Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(7):1005-10.
2001: Zou Y; Yao A; Zhu W; Kudoh S; Hiroi Y; Shimoyama M; Uozumi H; Kohmoto O; Takahashi T; Shibasaki F; Nagai R; Yazaki Y; Komuro I
Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin.
Circulation 2001;104(1):102-8.
2001: Zou Y; Hiroi Y; Uozumi H; Takimoto E; Toko H; Zhu W; Kudoh S; Mizukami M; Shimoyama M; Shibasaki F; Nagai R; Yazaki Y; Komuro I
Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy.
Circulation 2001;104(1):97-101.
2001: Hiroi Y; Kudoh S; Monzen K; Ikeda Y; Yazaki Y; Nagai R; Komuro I
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.
Nature genetics 2001;28(3):276-80.
2001: Watanabe A; Kurabayashi M; Arai M; Sekiguchi K; Nagai R
Combined effect of retinoic acid and basic FGF on PAI-1 gene expression in vascular smooth muscle cells.
Cardiovascular research 2001;51(1):151-9.
2001: Fukushima Y; Saitoh T; Anai M; Ogihara T; Inukai K; Funaki M; Sakoda H; Onishi Y; Ono H; Fujishiro M; Ishikawa T; Takata K; Nagai R; Omata M; Asano T
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.
Biochimica et biophysica acta 2001;1539(3):181-91.
2001: Arai N; Matsumoto A; Nishikawa N; Yonekura K; Eto Y; Kuwada Y; Shimamoto Ri; Sugiura S; Suzuki Ji; Takenaka K; Hirata Y; Nagai R; Aoyagi T
Beta-blocker therapy improved symptoms and exercise capacity in a patient with dynamic intra-right ventricular obstruction: an atypical Form of double-chambered right ventricle.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2001;14(6):650-3.
2001: Uozumi H; Hiroi Y; Zou Y; Takimoto E; Toko H; Niu P; Shimoyama M; Yazaki Y; Nagai R; Komuro I
gp130 plays a critical role in pressure overload-induced cardiac hypertrophy.
The Journal of biological chemistry 2001;276(25):23115-9.
2001: Chisaki K; Nakajima T; Iwasawa K; Iida H; Matsumoto A; Tada M; Komatsu Y; Hirose K; Miyamoto K; Okuda Y; Shiratori Y; Goto A; Hirata Y; Nagai R; Omata M
Enhancement of endothelial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseases.
Japanese heart journal 2001;42(3):339-53.
2001: Sakurai S; Takenaka K; Shiojima I; Watanabe F; Sonoda M; Uno K; Kuwada Y; Nakahara K; Nagai R
Traumatic tricuspid insufficiency.
Echocardiography (Mount Kisco, N.Y.) 2001;18(4):303-4.
2001: Monzen K; Hiroi Y; Kudoh S; Akazawa H; Oka T; Takimoto E; Hayashi D; Hosoda T; Kawabata M; Miyazono K; Ishii S; Yazaki Y; Nagai R; Komuro I
Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
The Journal of cell biology 2001;153(4):687-98.
2001: Tozawa R; Ishibashi S; Osuga J; Yamamoto K; Yagyu H; Ohashi K; Tamura Y; Yahagi N; Iizuka Y; Okazaki H; Harada K; Gotoda T; Shimano H; Kimura S; Nagai R; Yamada N
Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.
The Journal of biological chemistry 2001;276(16):12624-8.
2001: Miki H; Yamauchi T; Suzuki R; Komeda K; Tsuchida A; Kubota N; Terauchi Y; Kamon J; Kaburagi Y; Matsui J; Akanuma Y; Nagai R; Kimura S; Tobe K; Kadowaki T
Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Molecular and cellular biology 2001;21(7):2521-32.
2001: Aizawa K; Kaneko Y; Yamagishi T; Utsugi T; Suzuki T; Ishikawa S; Otaki A; Morishita Y; Hasegawa A; Kurabayashi M; Nagai R
Oozing from the pericardium as an etiology of cardiac tamponade associated with screw-in atrial leads.
Pacing and clinical electrophysiology : PACE 2001;24(3):381-3.
2001: Oishi Y; Sando Y; Tajima S; Maeno T; Maeno Y; Sato M; Hosono T; Suga T; Kurabayashi M; Nagai R
Indomethacin induced bulky lymphadenopathy and eosinophilic pneumonia.
Respirology (Carlton, Vic.) 2001;6(1):57-60.
2001: Takahashi T; Sugishita Y; Nojiri T; Shimizu T; Yao A; Kinugawa K; Harada K; Nagai R
Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes.
Biochemical and biophysical research communications 2001;281(4):1057-62.
2001: Chen Z; Ishibashi S; Perrey S; Osuga Ji; Gotoda T; Kitamine T; Tamura Y; Okazaki H; Yahagi N; Iizuka Y; Shionoiri F; Ohashi K; Harada K; Shimano H; Nagai R; Yamada N
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):372-7.
2001: Manita M; Kaneko Y; Taniguchi Y; Nakajima T; Ito T; Kurabayashi M; Nagai R
Typical atrial flutterlike tachycardia developing after inferior vena cava-tricuspid annulus isthmus ablation.
Pacing and clinical electrophysiology : PACE 2001;24(2):231-4.
2001: Shimoyama M; Hayashi D; Zou Y; Takimoto E; Mizukami M; Monzen K; Yazaki Y; Nagai R; Komuro I
[Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension]
Journal of cardiology 2001;37(2):114-8.
2001: Morita H; Kurihara H; Imai Y; Sugiyama T; Hamada C; Sakai E; Mori M; Nagai R
Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and myocardial infarction in Japanese. An approach entailing melting curve analysis with specific fluorescent hybridization probes.
Thrombosis and haemostasis 2001;85(2):226-30.
2001: Aizawa T; Ishizaka N; Kurokawa K; Nagai R; Nakajima H; Taguchi J; Ohno M
Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats.
Kidney international 2001;59(2):645-53.
2001: Iwasaki T; Iwasaki T; Aihara Y; Kanda T; Oriuchi N; Endo K; Katoh H; Suzuki T; Nagai R
Immunoscintigraphy of aortic dissection with 99mTc-labeled murine anti-smooth muscle myosin monoclonal antibody in rats.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(1):130-7.
2001: Sekiguchi K; Kurabayashi M; Oyama Y; Aihara Y; Tanaka T; Sakamoto H; Hoshino Y; Kanda T; Yokoyama T; Shimomura Y; Iijima H; Ohyama Y; Nagai R
Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.
Circulation research 2001;88(1):52-8.
2001: Kanai H; Tanaka T; Aihara Y; Takeda S; Kawabata M; Miyazono K; Nagai R; Kurabayashi M
Transforming growth factor-beta/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells.
Circulation research 2001;88(1):30-6.
2001: Morita H; Kurihara H; Yoshida S; Saito Y; Shindo T; Oh-Hashi Y; Kurihara Y; Yazaki Y; Nagai R
Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Circulation 2001;103(1):133-9.
2001: Fukushima Y; Saitoh T; Anai M; Tsukuda K; Onishi Y; Sakoda H; Inukai K; Ogihara T; Funaki M; Ono H; Fujishiro M; Ishikawa T; Nagai R; Omata M; Asano T
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.
The pharmacogenomics journal 2001;1(1):78-83.
2001: Iwasa H; Kurabayashi M; Nagai R; Nakamura Y; Tanaka T
Genetic variations in five genes involved in the excitement of cardiomyocytes.
Journal of human genetics 2001;46(9):549-52.
2001: Takenaka K; Kuwada Y; Sonoda M; Uno K; Asakawa M; Sakurai S; Takahashi T; Sasaki K; Matsuzaki M; Kikuchi A; Amagai R; Furudate N; Nagai R
Anthracycline-induced cardiomyopathies evaluated by tissue Doppler tracking system and strain rate imaging.
Journal of cardiology 2001;37 Suppl 1():129-32.
2001: Iwasa H; Kurabayashi M; Nagai R; Nakamura Y; Tanaka T
Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome.
Journal of human genetics 2001;46(3):158-62.
2001: Itoh T; Kikuchi K; Odagawa Y; Takata S; Yano K; Okada S; Haneda N; Ogawa S; Nakano O; Kawahara Y; Kasai H; Nakayama T; Fukutomi T; Sakurada H; Shimizu A; Yazaki Y; Nagai R; Nakamura Y; Tanaka T
Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome.
Journal of human genetics 2001;46(1):38-40.
2000: Ito T; Kaneko Y; Taniguchi Y; Nakajima T; Manita M; Suguta M; Kurabayashi M; Nagai R
Long RP tachycardia with RR alternation.
Pacing and clinical electrophysiology : PACE 2000;23(12):2128-30.
2000: Maeno Y; Sando Y; Ubukata M; Maeno T; Tajima S; Hosono T; Sato M; Tsukagoshi M; Suga T; Kurabayashi M; Nagai R
Pulmonary nocardiosis during immunosuppressive therapy for idiopathic pulmonary fibrosis.
Respirology (Carlton, Vic.) 2000;5(4):393-5.
2000: Ogata T; Kurabayashi M; Hoshino Y I; Sekiguchi K I; Kawai-Kowase K; Ishikawa S; Morishita Y; Nagai R
Inducible expression of basic transcription factor-binding protein 2 (BTEB2), a member of zinc finger family of transcription factors, in cardiac allograft vascular disease.
Transplantation 2000;70(11):1653-6.
2000: Hangaishi M; Ishizaka N; Aizawa T; Kurihara Y; Taguchi J; Nagai R; Kimura S; Ohno M
Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo.
Biochemical and biophysical research communications 2000;279(2):582-8.
2000: Sumino H; Nakamura T; Kanda T; Sato K; Sakamaki T; Takahashi T; Saito Y; Hoshino J; Kurashina T; Nagai R
Effect of enalapril on exhaled nitric oxide in normotensive and hypertensive subjects.
Hypertension 2000;36(6):934-40.
2000: Kanda T; Tanaka T; Sekiguchi K; Seta Y; Kurimoto M; Wilson McManus J E; Nagai R; Yang D; McManus B M; Kobayashi I
Effect of interleukin-18 on viral myocarditis: enhancement of interferon- gamma and natural killer cell activity.
Journal of molecular and cellular cardiology 2000;32(12):2163-71.
2000: Aikawa R; Nawano M; Gu Y; Katagiri H; Asano T; Zhu W; Nagai R; Komuro I
Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt.
Circulation 2000;102(23):2873-9.
2000: Fukui E; Yamashita T; Sezaki K; Ajiki K; Inoue M; Hayami N; Kasaoka Y; Omata M; Murakawa Y; Nagai R
Overdrive suppression of antegrade conduction over the accessory pathway.
Japanese heart journal 2000;41(6):767-72.
2000: Murakawa Y; Yamashita T; Ajiki K; Suzuki J; Hayami N; Fukui E; Kasaoka Y; Omata M; Nagai R
Is the QT interval an indicator of autonomic state?
Japanese heart journal 2000;41(6):713-21.
2000: Ogata T; Kurabayashi M; Hoshino Y; Ishikawa S; Takeyoshi I; Morishita Y; Nagai R
Inducible expression of BTEB2, a member of the zinc-finger family of transcription factors, in cardiac allograft arteriosclerosis.
Transplantation proceedings 2000;32(7):2032-3.
2000: Kubota N; Tobe K; Terauchi Y; Eto K; Yamauchi T; Suzuki R; Tsubamoto Y; Komeda K; Nakano R; Miki H; Satoh S; Sekihara H; Sciacchitano S; Lesniak M; Aizawa S; Nagai R; Kimura S; Akanuma Y; Taylor S I; Kadowaki T
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Diabetes 2000;49(11):1880-9.
2000: Hoshino Y; Kurabayashi M; Kanda T; Hasegawa A; Sakamoto H; Okamoto E; Kowase K; Watanabe N; Manabe I; Suzuki T; Nakano A; Takase S; Wilcox J N; Nagai R
Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis.
Circulation 2000;102(20):2528-34.
2000: Sata M; Maejima Y; Adachi F; Fukino K; Saiura A; Sugiura S; Aoyagi T; Imai Y; Kurihara H; Kimura K; Omata M; Makuuchi M; Hirata Y; Nagai R
A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.
Journal of molecular and cellular cardiology 2000;32(11):2097-104.
2000: Tanaka T; Kanai H; Sekiguchi K; Aihara Y; Yokoyama T; Arai M; Kanda T; Nagai R; Kurabayashi M
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
Journal of molecular and cellular cardiology 2000;32(11):1955-67.
2000: Zhu W; Shiojima I; Hiroi Y; Zou Y; Akazawa H; Mizukami M; Toko H; Yazaki Y; Nagai R; Komuro I
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.
The Journal of biological chemistry 2000;275(45):35291-6.
2000: Saito S; Hiroi Y; Zou Y; Aikawa R; Toko H; Shibasaki F; Yazaki Y; Nagai R; Komuro I
beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes.
The Journal of biological chemistry 2000;275(44):34528-33.
2000: Shimoyama M; Hayashi D; Zou Y; Takimoto E; Mizukami M; Monzen K; Kudoh S; Hiroi Y; Yazaki Y; Nagai R; Komuro I
Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension.
Circulation 2000;102(16):1996-2004.
2000: Toshima S; Hasegawa A; Kurabayashi M; Itabe H; Takano T; Sugano J; Shimamura K; Kimura J; Michishita I; Suzuki T; Nagai R
Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(10):2243-7.
2000: Yamauchi T; Yamauchi N; Ueki K; Sugiyama T; Waki H; Miki H; Tobe K; Matsuda S; Tsushima T; Yamamoto T; Fujita T; Taketani Y; Fukayama M; Kimura S; Yazaki Y; Nagai R; Kadowaki T
Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer.
The Journal of biological chemistry 2000;275(43):33937-44.
2000: Hasty A H; Shimano H; Yahagi N; Amemiya-Kudo M; Perrey S; Yoshikawa T; Osuga J; Okazaki H; Tamura Y; Iizuka Y; Shionoiri F; Ohashi K; Harada K; Gotoda T; Nagai R; Ishibashi S; Yamada N
Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
The Journal of biological chemistry 2000;275(40):31069-77.
2000: Ikeuchi H; Sando Y; Tajima S; Sato M; Hosono T; Maeno T; Maeno Y; Suga T; Kurabayashi M; Nagai R
[PL granule-induced pneumonia requiring mechanical ventilation]
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2000;38(9):682-6.
2000: Aikawa R; Komuro I; Nagai R; Yazaki Y
Rho plays an important role in angiotensin II-induced hypertrophic responses in cardiac myocytes.
Molecular and cellular biochemistry 2000;212(1-2):177-82.
2000: Saito Y; Nakamura T; Ohyama Y; Suzuki T; Iida A; Shiraki-Iida T; Kuro-o M; Nabeshima Y; Kurabayashi M; Nagai R
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome.
Biochemical and biophysical research communications 2000;276(2):767-72.
2000: Utsugi T; Ohno T; Ohyama Y; Uchiyama T; Saito Y; Matsumura Y; Aizawa H; Itoh H; Kurabayashi M; Kawazu S; Tomono S; Oka Y; Suga T; Kuro-o M; Nabeshima Y; Nagai R
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging.
Metabolism: clinical and experimental 2000;49(9):1118-23.
2000: Nakajima T; Kurabayashi M; Ohyama Y; Kaneko Y; Furukawa T; Itoh T; Taniguchi Y; Tanaka T; Nakamura Y; Hiraoka M; Nagai R
Characterization of S818L mutation in HERG C-terminus in LQT2. Modification of activation-deactivation gating properties.
FEBS letters 2000;481(2):197-203.
2000: Seko Y; Takahashi N; Tada Y; Yagita H; Okumura K; Nagai R
Restricted usage of T-cell receptor Vgamma-Vdelta genes and expression of costimulatory molecules in Takayasu's arteritis.
International journal of cardiology 2000;75 Suppl 1():S77-83; discussion S85-7.
2000: Oishi Y; Arai M; Kiraku J; Doi H; Uchiyama T; Hasegawa A; Kurabayashi M; Nagai R
Unclassified connective tissue disease presenting as cardiac tamponade: a case report.
Japanese circulation journal 2000;64(8):619-22.
2000: Ohashi K; Ishibashi S; Osuga J; Tozawa R; Harada K; Yahagi N; Shionoiri F; Iizuka Y; Tamura Y; Nagai R; Illingworth D R; Gotoda T; Yamada N
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
Journal of lipid research 2000;41(8):1199-204.
2000: Kurihara Y; Kurihara H; Morita H; Cao W H; Ling G Y; Kumada M; Kimura S; Nagai R; Yazaki Y; Kuwaki T
Role of endothelin-1 in stress response in the central nervous system.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(2):R515-21.
2000: Murata I; Sonoda M; Morita T; Nakamura F; Takenaka K; Nagai R
The clinical significance of reversed flow in the main pulmonary artery detected by doppler color flow imaging.
Chest 2000;118(2):336-41.
2000: Nakajima T; Okuda Y; Chisaki K; Shin W S; Iwasawa K; Morita T; Matsumoto A; Suzuki J I; Suzuki S; Yamada N; Toyo-Oka T; Nagai R; Omata M
Bile acids increase intracellular Ca(2+) concentration and nitric oxide production in vascular endothelial cells.
British journal of pharmacology 2000;130(7):1457-67.
2000: Ishizaka N; Aizawa T; Mori I; Taguchi J; Yazaki Y; Nagai R; Ohno M
Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H672-8.
2000: Oonuma H; Nakajima T; Nagata T; Iwasawa K; Wang Y; Hazama H; Morita Y; Yamamoto K; Nagai R; Omata M
Endothelin-1 is a potent activator of nonselective cation currents in human bronchial smooth muscle cells.
American journal of respiratory cell and molecular biology 2000;23(2):213-21.
2000: Suzuki M; Ishizaka N; Hwang W M; Tsukamoto K; Minami K; Aizawa T; Mori I; Taguchi J; Nagai R; Ohno M
Application of hydrostatic pressure facilitates ex vivo adenovirus gene transfer into rabbit aortas.
Biochemical and biophysical research communications 2000;274(2):422-6.
2000: Aihara Y; Kurabayashi M; Tanaka T; Takeda S I; Tomaru K; Sekiguchi K I; Ohyama Y; Nagai R
Doxorubicin represses CARP gene transcription through the generation of oxidative stress in neonatal rat cardiac myocytes: possible role of serine/threonine kinase-dependent pathways.
Journal of molecular and cellular cardiology 2000;32(8):1401-14.
2000: Kotajima N; Hirakata T; Kanda T; Yokoyama T; Hoshino Y; Tanaka T; Tamura J; Nagai R; Kobayasii I
Prolongation of QT interval and ventricular septal hypertrophy.
Japanese heart journal 2000;41(4):463-9.
2000: Suzuki J; Nagai R; Nishikawa J; Ohotomo K; Toyo-Oka T; Omata M
Evaluation of the heart with magnetic resonance imaging.
Japanese heart journal 2000;41(4):417-24.
2000: Nakajima H; Ishizaka N; Hangaishi M; Taguchi J; Itoh J; Igarashi R; Mizushima Y; Nagai R; Ohno M
Lecithinized copper, zinc-superoxide dismutase ameliorates prolonged hypoxia-induced injury of cardiomyocytes.
Free radical biology & medicine 2000;29(1):34-41.
2000: Aizawa K; Nakamura T; Sumino H; Saito Y; Hoshino J; Kurashina T; Kumakura H; Ichikawa S; Nagai R
Renovascular hypertension observed in a patient with antiphospholipid-antibody syndrome.
Japanese circulation journal 2000;64(7):541-3.
2000: Kasama S; Toyama T; Hoshizaki H; Oshima S; Taniguchi K; Iwasaki T; Suzuki T; Nagai R
[Prediction of cardiac sympathetic nerve activity and cardiac functional outcome after treatment in patients with dilated cardiomyopathy: examination using dobutamine gated blood pool scintigraphy]
Journal of cardiology 2000;36(1):29-35.
2000: Morita H; Kurihara H; Kuwaki T; Hamada C; Kitaoka M; Suzuki S; Yazaki Y; Nagai R
Homocysteine as a risk factor for restenosis after coronary angioplasty.
Thrombosis and haemostasis 2000;84(1):27-31.
2000: Sata M; Kakoki M; Nagata D; Nishimatsu H; Suzuki E; Aoyagi T; Sugiura S; Kojima H; Nagano T; Kangawa K; Matsuo H; Omata M; Nagai R; Hirata Y
Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism.
Hypertension 2000;36(1):83-8.
2000: Aihara Y; Kurabayashi M; Saito Y; Ohyama Y; Tanaka T; Takeda S; Tomaru K; Sekiguchi K; Arai M; Nakamura T; Nagai R
Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter.
Hypertension 2000;36(1):48-53.
2000: Hiroi Y; Chen R; Sawa H; Hosoda T; Kudoh S; Kobayashi Y; Aburatani H; Nagashima K; Nagai R; Yazaki Y; Medof M E; Komuro I
Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1.
American journal of physiology. Cell physiology 2000;279(1):C205-12.
2000: Sugishita Y; Takahashi T; Shimizu T; Yao A; Kinugawa K; Sugishita K; Harada K; Matsui H; Nagai R
Expression of genes encoding vascular endothelial growth factor and its Flk-1 receptor in the chick embryonic heart.
Journal of molecular and cellular cardiology 2000;32(6):1039-51.
2000: Utsugi T; Yoshida A; Kanda T; Kobayashi I; Kurabayashi M; Tomono S; Kawazu S; Tajima Y; Nagai R
Oral administration of branched chain amino acids improves virus-induced glucose intolerance in mice.
European journal of pharmacology 2000;398(3):409-14.
2000: Shiojima I; Oka T; Hiroi Y; Nagai R; Yazaki Y; Komuro I
Transcriptional regulation of human cardiac homeobox gene CSX1.
Biochemical and biophysical research communications 2000;272(3):749-57.
2000: Yokoyama I; Yonekura K; Ohtake T; Yang W; Shin W S; Yamada N; Ohtomo K; Nagai R
Coronary microangiopathy in type 2 diabetic patients: relation to glycemic control, sex, and microvascular angina rather than to coronary artery disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(6):978-85.
2000: Sumino H; Nakamura T; Kanda T; Sakamaki T; Sato K; Saito Y; Hoshino J; Kurashina T; Ono Z; Takahashi T; Ichikawa S; Kurabayashi M; Nagai R
Effects of antihypertensive therapy on blood pressure and left ventricular hypertrophy in patients with severe hypertension.
Japanese heart journal 2000;41(3):339-48.
2000: Sekiguchi K; Kanda T; Ono Z; Tanaka T; Yokoyama T; Aihara Y; Toyama T; Sakamaki T; Kobayashi I; Kurabayashi M; Nagai R
Augmented responses of angiotensin I and II in patients with ischemic heart disease: relation to left ventricular function.
Japanese heart journal 2000;41(3):269-78.
2000: Nagai R; Saito Y; Ohyama Y; Aizawa H; Suga T; Nakamura T; Kurabayashi M; Kuroo M
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases.
Cellular and molecular life sciences : CMLS 2000;57(5):738-46.
2000: Yokoyama I; Yonekura K; Ohtake T; Kawamura H; Matsumoto A; Inoue Y; Aoyagi T; Sugiura S; Omata M; Ohtomo K; Nagai R
Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with non-insulin-dependent diabetes mellitus.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2000;7(3):242-8.
2000: Nagai R; Kowase K; Kurabayashi M
Transcriptional regulation of smooth muscle phenotypic modulation.
Annals of the New York Academy of Sciences 2000;902():214-22; discussion 222-3.
2000: Ueki K; Yamauchi T; Tamemoto H; Tobe K; Yamamoto-Honda R; Kaburagi Y; Akanuma Y; Yazaki Y; Aizawa S; Nagai R; Kadowaki T
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
The Journal of clinical investigation 2000;105(10):1437-45.
2000: Shindo T; Kurihara H; Kuno K; Yokoyama H; Wada T; Kurihara Y; Imai T; Wang Y; Ogata M; Nishimatsu H; Moriyama N; Oh-hashi Y; Morita H; Ishikawa T; Nagai R; Yazaki Y; Matsushima K
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.
The Journal of clinical investigation 2000;105(10):1345-52.
2000: Shindo T; Kurihara H; Maemura K; Kurihara Y; Kuwaki T; Izumida T; Minamino N; Ju K H; Morita H; Oh-hashi Y; Kumada M; Kangawa K; Nagai R; Yazaki Y
Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.
Circulation 2000;101(19):2309-16.
2000: Zhu W; Zou Y; Shiojima I; Kudoh S; Aikawa R; Hayashi D; Mizukami M; Toko H; Shibasaki F; Yazaki Y; Nagai R; Komuro I
Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy.
The Journal of biological chemistry 2000;275(20):15239-45.
2000: Ogata T; Kurabayashi M; Hoshino Y i; Sekiguchi K i; Ishikawa S; Morishita Y; Nagai R
Inducible expression of basic transcription element-binding protein 2 in proliferating smooth muscle cells at the vascular anastomotic stricture.
The Journal of thoracic and cardiovascular surgery 2000;119(5):983-9.
2000: Takimoto E; Mizuno T; Terasaki F; Shimoyama M; Honda H; Shiojima I; Hiroi Y; Oka T; Hayashi D; Hirai H; Kudoh S; Toko H; Kawamura K; Nagai R; Yazaki Y; Komuro I
Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice.
Biochemical and biophysical research communications 2000;270(3):1074-9.
2000: Uchiyama T; Kurabayashi M; Ohyama Y; Utsugi T; Akuzawa N; Sato M; Tomono S; Kawazu S; Nagai R
Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):1155-61.
2000: Oka T; Shiojima I; Monzen K; Kudoh S; Hiroi Y; Shiokawa K; Asashima M; Nagai R; Yazaki Y; Komuro I
Fibroblast growth factor plays a critical role in SM22alpha expression during Xenopus embryogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):907-14.
2000: Suzuki T; Yamaoki K; Nakajima O; Yamazaki T; Yamada Y; Akioka H; Yazaki Y; Nagai R
Screening for cardiac dysfunction in asymptomatic patients by measuring B-type natriuretic peptide levels.
Japanese heart journal 2000;41(2):205-14.
2000: Suzuki M; Ishizaka N; Tsukamoto K; Minami K; Taguchi J; Nagai R; Ohno M
Pressurization facilitates adenovirus-mediated gene transfer into vein graft.
FEBS letters 2000;470(3):370-4.
2000: Maeno T; Sando Y; Tsukagoshi M; Suga T; Endo M; Seki R; Ooyama Y; Yamagishi T; Kaneko Y; Kanda T; Iwasaki T; Kurabayashi M; Nagai R
Pleural amyloidosis in a patient with intractable pleural effusion and multiple myeloma.
Respirology (Carlton, Vic.) 2000;5(1):79-80.
2000: Aizawa T; Ishizaka N; Taguchi J i; Nagai R; Mori I; Tang S S; Ingelfinger J R; Ohno M
Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection.
Hypertension 2000;35(3):800-6.
2000: Kiraku J; Sugiyama T; Ashida T; Takahashi N; Fujii J; Kuro-o M; Nagai R
Increases in intracellular calcium of arterial smooth muscle cells in transgenic mice overexpressing Na+/H+ exchanger.
Journal of cardiovascular pharmacology 2000;35(3):511-3.
2000: Maeno T; Maeno Y; Sando Y; Takahashi T; Yarita H; Tsukagoshi M; Suga T; Kurabayashi M; Nagai R
Nuclear hypersegmentation precedes the increase in blood eosinophils in acute eosinophilic pneumonia.
Internal medicine (Tokyo, Japan) 2000;39(2):157-9.
2000: Morita H; Nagai R
[Genetic diagnosis and cardiovascular diseases]
Nippon rinsho. Japanese journal of clinical medicine 2000;58(2):485-94.
2000: Kanda T; Kobayashi I; Nagai R
Cardiac interleukin-6 in ischemic myocardium.
Circulation 2000;101(8):E86.
2000: Sugishita Y; Shimizu T; Yao A; Kinugawa K i; Nojiri T; Harada K; Matsui H; Nagai R; Takahashi T
Lipopolysaccharide augments expression and secretion of vascular endothelial growth factor in rat ventricular myocytes.
Biochemical and biophysical research communications 2000;268(2):657-62.
2000: Kaji Y; Usui T; Oshika T; Matsubara M; Yamashita H; Araie M; Murata T; Ishibashi T; Nagai R; Horiuchi S; Amano S
Advanced glycation end products in diabetic corneas.
Investigative ophthalmology & visual science 2000;41(2):362-8.
2000: Tanaka T; Kurabayashi M; Aihara Y; Ohyama Y; Nagai R
Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by Sp1 in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):392-401.
2000: Akuzawa N; Kurabayashi M; Ohyama Y; Arai M; Nagai R
Zinc finger transcription factor Egr-1 activates Flt-1 gene expression in THP-1 cells on induction for macrophage differentiation.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):377-84.
2000: Morita H; Nagai R
[Heart failure]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():763-5.
2000: Takama N; Nakamura T; Nagai R
[Hypertensive hypertrophic cardiomyopathy]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():749-53.
2000: Suguta M; Nakamura T; Kurabayashi M; Nagai R
[Prognostic significance of quantification of left ventricular mass in hypertensive patients]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():740-3.
2000: Saito Y; Kuroo M; Nabeshima Y; Nagai R
[klotho gene]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():561-5.
2000: Saito Y; Nakamura T; Nagai R
[Vascular endothelium and vascular smooth muscle cells]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():335-9.
2000: Saito Y; Nakamura T; Nagai R
[Coronary microcirculation]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():317-20.
2000: Aikawa R; Komuro I; Nagai R
[Cardiac gene therapy]
Nippon rinsho. Japanese journal of clinical medicine 2000;58(1):79-85.
2000: Seta Y; Kanda T; Yokoyama T; Arai M; Sekiguchi K; Tanaka T; Kobayashi I; Kurabayashi M; Nagai R
Therapy with the nonpeptide endothelin receptor antagonist 97-139 in a murine model of congestive heart failure: reduction of cardiac mass and myofiber hypertrophy.
Japanese heart journal 2000;41(1):79-85.
2000: Kaneko K; Kanda T; Hasegawa A; Suzuki T; Kobayashi I; Nagai R
C-reactive protein as a prognostic marker in lymphocytic myocarditis.
Japanese heart journal 2000;41(1):41-7.
2000: Seko Y; Nishimura H; Takahashi N; Ashida T; Nagai R
Serum levels of vascular endothelial growth factor and transforming growth factor-beta1 in patients with atrial fibrillation undergoing defibrillation therapy.
Japanese heart journal 2000;41(1):27-32.
2000: Aizawa K; Nakamura T; Ohyama Y; Saito Y; Hoshino J; Kanda T; Sumino H; Nagai R
Renal artery stenosis associated with epidermal nevus syndrome.
Nephron 2000;84(1):67-70.
2000: Sato H; Iwasaki T; Toyama T; Kaneko Y; Inoue T; Endo K; Nagai R
Prediction of functional recovery after revascularization in coronary artery disease using (18)F-FDG and (123)I-BMIPP SPECT.
Chest 2000;117(1):65-72.
2000: Arai M; Yoguchi A; Takizawa T; Yokoyama T; Kanda T; Kurabayashi M; Nagai R
Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription.
Circulation research 2000;86(1):8-14.
2000: Terauchi Y; Kubota N; Tamemoto H; Sakura H; Nagai R; Akanuma Y; Kimura S; Kadowaki T
Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Diabetes 2000;49(1):82-6.
2000: Suga T; Kurabayashi M; Sando Y; Ohyama Y; Maeno T; Maeno Y; Aizawa H; Matsumura Y; Kuwaki T; Kuro-O M; Nabeshima Y i; Nagai R
Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.
American journal of respiratory cell and molecular biology 2000;22(1):26-33.
2000: Hamada Y; Kanda T; Ishikawa S; Imai S; Nagai R; Matsui K; Ohashi N; Morishita Y
Na+/H+ exchange inhibitor reduces vascular injury caused by ischemia-reperfusion in the rat hind limb.
Research communications in molecular pathology and pharmacology 2000;107(3-4):259-67.
2000: Oyama Y; Kurabayashi M; Akuzawa N; Nagai R
Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells.
Journal of atherosclerosis and thrombosis 2000;7(2):77-82.
2000: Iwasa H; Itoh T; Nagai R; Nakamura Y; Tanaka T
Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population.
Journal of human genetics 2000;45(3):182-3.
1999: Hamada Y; Ishikawa S; Kanda T; Imai S; Nagai R; Matsui K; Ohashi N; Morishita Y
Sodium/hydrogen ion exchange inhibitor ameliorates ischaemia-reperfusion injuries in the rat hind limb.
International angiology : a journal of the International Union of Angiology 1999;18(4):320-6.
1999: Hoshino Y; Nagai R
[Hereditary assessment of cardiovascular disease]
Nippon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():718-25.
1999: Takizawa T; Arai M; Yoguchi A; Tomaru K; Kurabayashi M; Nagai R
Transcription of the SERCA2 gene is decreased in pressure-overloaded hearts: A study using in vivo direct gene transfer into living myocardium.
Journal of molecular and cellular cardiology 1999;31(12):2167-74.
1999: Hasegawa A; Toshima S; Nakano A; Nagai R
[Oxidized LDL in patients with coronary heart disease and normal subjects]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(12):2754-8.
1999: Ishizaka N; Nakao A; Ohishi N; Suzuki M; Aizawa T; Taguchi J; Nagai R; Shimizu T; Ohno M
Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat.
FEBS letters 1999;463(1-2):155-9.
1999: Nagase T; Kurihara H; Kurihara Y; Aoki-Nagase T; Nagai R; Ouchi Y
Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(6):2020-4.
1999: Shimoyama M; Hayashi D; Takimoto E; Zou Y; Oka T; Uozumi H; Kudoh S; Shibasaki F; Yazaki Y; Nagai R; Komuro I
Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy.
Circulation 1999;100(24):2449-54.
1999: Yahagi N; Shimano H; Hasty A H; Amemiya-Kudo M; Okazaki H; Tamura Y; Iizuka Y; Shionoiri F; Ohashi K; Osuga J; Harada K; Gotoda T; Nagai R; Ishibashi S; Yamada N
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
The Journal of biological chemistry 1999;274(50):35840-4.
1999: Shiojima I; Aikawa M; Suzuki J; Yazaki Y; Nagai R
Embryonic smooth muscle myosin heavy chain SMemb is expressed in pressure-overloaded cardiac fibroblasts.
Japanese heart journal 1999;40(6):803-18.
1999: Suzuki J; Shin W S; Shimamoto R; Yamazaki T; Tsuji T; Murakawa Y; Nakajima T; Toyo-oka T; Nishikawa J; Ohotomo K; Nagai R; Omata M
Clinical implication of left precordial T wave inversions in the presence of complete right bundle branch block.
Japanese heart journal 1999;40(6):745-53.
1999: Sekiguchi K; Yokoyama T; Kurabayashi M; Okajima F; Nagai R
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.
Circulation research 1999;85(11):1000-8.
1999: Zhu W; Zou Y; Aikawa R; Harada K; Kudoh S; Uozumi H; Hayashi D; Gu Y; Yamazaki T; Nagai R; Yazaki Y; Komuro I
MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes.
Circulation 1999;100(20):2100-7.
1999: Aihara Y; Kurabayashi M; Arai M; Kedes L; Nagai R
Molecular cloning of rabbit CARP cDNA and its regulated expression in adriamycin-cardiomyopathy.
Biochimica et biophysica acta 1999;1447(2-3):318-24.
1999: Kawai-Kowase K; Kurabayashi M; Hoshino Y; Ohyama Y; Nagai R
Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells.
Circulation research 1999;85(9):787-95.
1999: Suzuki T; Katoh H; Nagai R
Biochemical diagnosis of aortic dissection: from bench to bedside.
Japanese heart journal 1999;40(5):527-34.
1999: Sakamoto H; Sakamaki T; Kanda T; Kurabayashi M; Nagai R; Fujii J
Loculated pericardial effusion due to congestive heart failure: an unusual case of vanishing tumor--a case report.
Angiology 1999;50(8):683-7.
1999: Seko Y; Takahashi N; Sabe H; Tobe K; Kadowaki T; Nagai R
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;262(1):290-6.
1999: Hiroi S; Harada H; Nishi H; Satoh M; Nagai R; Kimura A
Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese.
Biochemical and biophysical research communications 1999;261(2):332-9.
1999: Kurihara H; Kurihara Y; Nagai R; Yazaki Y
Endothelin and neural crest development.
Cellular and molecular biology (Noisy-le-Grand, France) 1999;45(5):639-51.
1999: Koitabashi N; Utsugi T; Seki R; Okamoto E; Sando Y; Kaneko Y; Nagai R
Biopsy-proven cardiomyopathy in heterozygous Fabry's disease.
Japanese circulation journal 1999;63(7):572-5.
1999: Saito S; Aikawa R; Shiojima I; Nagai R; Yazaki Y; Komuro I
Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.
FEBS letters 1999;456(1):103-7.
1999: Yoshida A; Kanda T; Sakamoto H; Masuda H; Iwasaki T; Nakajima T; Kobayashi I; Nagai R
Sudden death with malignant hemangioendothelioma originating in the pericardium--a case report.
Angiology 1999;50(7):607-11.
1999: Saito Y; Kuroo M; Nabeshima Y; Nagai R
[The protective role of Klotho gene on vascular endothelium]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(7):1514-8.
1999: Watanabe N; Kurabayashi M; Shimomura Y; Kawai-Kowase K; Hoshino Y; Manabe I; Watanabe M; Aikawa M; Kuro-o M; Suzuki T; Yazaki Y; Nagai R
BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene.
Circulation research 1999;85(2):182-91.
1999: Kiraku J; Nakamura T; Sugiyama T; Takahashi N; Kuro-o M; Fujii J; Nagai R
Dietary salt loading increases nitric oxide synthesis in transgenic mice overexpressing sodium-proton exchanger.
Japanese journal of pharmacology 1999;80(2):181-3.
1999: Ito Y; Imai S; Ui G; Nakano M; Imai K; Kamiyama H; Naganuma F; Matsui K; Ohashi N; Nagai R
A Na+-H+ exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion.
European journal of pharmacology 1999;374(3):355-66.
1999: Yokoyama T; Sekiguchi K; Tanaka T; Tomaru K; Arai M; Suzuki T; Nagai R
Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts.
The American journal of physiology 1999;276(6 Pt 2):H1968-76.
1999: Okumura W; Iwasaki T; Ueda T; Seki R; Miyajima A; Hatori T; Sato H; Toyama T; Suzuki T; Matsubara K; Otake H; Aoyagi K; Inoue T; Endo K; Nagai R
[Usefulness of 18F-FDG PET for diagnosis of cardiac sarcoidosis]
Kaku igaku. The Japanese journal of nuclear medicine 1999;36(4):341-8.
1999: Tanehata M; Adachi H; Oshima S; Taniguchi K; Itoh H; Hasegawa A; Nagai R
The time from anaerobic threshold (AT) to respiratory compensation point reflects the rate of aerobic and anaerobic metabolism after the AT in chronic heart failure patients.
Japanese circulation journal 1999;63(4):274-7.
1999: Sakamoto H; Sakamaki T; Tani T; Sugai Y; Nakamura T; Ono Z; Kanda T; Kurabayashi M; Nagai R
"White coat effect" induced by therapist's presence during speech therapy for stroke rehabilitation: a single case study.
Archives of physical medicine and rehabilitation 1999;80(4):470-2.
1999: Toyama T; Aihara Y; Iwasaki T; Hasegawa A; Suzuki T; Nagai R; Endo K; Hoshizaki H; Oshima S; Taniguchi K
Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(2):217-23.
1999: Kanda T; Koike H; Arai M; Wilson J E; Carthy C M; Yang D; McManus B M; Nagai R; Kobayashi I
Increased severity of viral myocarditis in mice lacking lymphocyte maturation.
International journal of cardiology 1999;68(1):13-22.
1999: Yokoyama T; Arai M; Sekiguchi K; Tanaka T; Kanda T; Suzuki T; Nagai R
Tumor necrosis factor-alpha decreases the phosphorylation levels of phospholamban and troponin I in spontaneously beating rat neonatal cardiac myocytes.
Journal of molecular and cellular cardiology 1999;31(1):261-73.
1999: Kaneko K; Kanda T; Yamauchi Y; Hasegawa A; Iwasaki T; Arai M; Suzuki T; Kobayashi I; Nagai R
C-Reactive protein in dilated cardiomyopathy.
Cardiology 1999;91(4):215-9.
1999: Sumino H; Kanda T; Nakamura T; Sakamaki T; Sakamoto H; Sato K; Tange S; Ichikawa S; Nagai R
Steroid therapy is effective in a young patient with an inflammatory abdominal aortic aneurysm.
Journal of medicine 1999;30(1-2):67-74.
1999: Kanda T; Nakano M; Yokoyama T; Hoshino Y; Okajima F; Tanaka T; Saito Y; Nagai R; Kobayashi I
Heat stress aggravates viral myocarditis in mice.
Life sciences 1999;64(2):93-101.
1999: Nakamura T; Igarashi R; Kurashina T; Saito Y; Hoshino J; Sumino H; Sakamoto H; Nagai R
Lecithinized superoxide dismutase induces vasodilation; evidence of direct contribution of superoxide anions to modulating vascular tone.
Life sciences 1999;64(4):PL65-70.
1998: Nakamura T; Kurashina T; Saito Y; Sumino H; Akuzawa N; Aizawa H; Sakamoto H; Ono Z; Nagai R
ET(A) receptor antagonist ameliorates nephrosclerosis and left ventricular hypertrophy induced in rat by prolonged inhibition of nitric oxide synthesis.
Hypertension research : official journal of the Japanese Society of Hypertension 1998;21(4):251-7.
1998: Hoshino J; Nakamura T; Kurashina T; Saito Y; Sumino H; Ono Z; Sakamoto H; Kowase K; Nagai R
Antagonism of ANG II type 1 receptors protects the endothelium during the early stages of renal hypertension in rats.
The American journal of physiology 1998;275(6 Pt 2):R1950-7.
1998: Tanehata M; Adachi H; Oshima S; Taniguchi K; Itoh H; Hasegawa A; Nagai R
Improved oxygen utilization during mild exercise in heart failure.
Japanese circulation journal 1998;62(10):741-4.
1998: Itoh T; Tanaka T; Nagai R; Kikuchi K; Ogawa S; Okada S; Yamagata S; Yano K; Yazaki Y; Nakamura Y
Genomic organization and mutational analysis of KVLQT1, a gene responsible for familial long QT syndrome.
Human genetics 1998;103(3):290-4.
1998: Aizawa H; Saito Y; Nakamura T; Inoue M; Imanari T; Ohyama Y; Matsumura Y; Masuda H; Oba S; Mise N; Kimura K; Hasegawa A; Kurabayashi M; Kuro-o M; Nabeshima Y; Nagai R
Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats.
Biochemical and biophysical research communications 1998;249(3):865-71.
1998: Suzuki T; Hayashi D; Yamazaki T; Mizuno T; Kanda Y; Komuro I; Kurabayashi M; Yamaoki K; Mitani K; Hirai H; Nagai R; Yazaki Y
Elevated B-type natriuretic peptide levels after anthracycline administration.
American heart journal 1998;136(2):362-3.
1998: Matsuse T; Ohga E; Teramoto S; Fukayama M; Nagai R; Horiuchi S; Ouchi Y
Immunohistochemical localisation of advanced glycation end products in pulmonary fibrosis.
Journal of clinical pathology 1998;51(7):515-9.
1998: Sakamoto H; Sakamaki T; Kanda T; Ito Y; Sumino H; Masuda H; Ohyama Y; Ono Z; Kurabayashi M; Kobayashi I; Nagai R
The somatostatin analog, octreotide, inhibits in vitro outgrowth of smooth muscle cells from canine coronary and carotid atherosclerotic plaque tissues.
Research communications in molecular pathology and pharmacology 1998;101(1):25-34.
1998: Saito Y; Yamagishi T; Nakamura T; Ohyama Y; Aizawa H; Suga T; Matsumura Y; Masuda H; Kurabayashi M; Kuro-o M; Nabeshima Y; Nagai R
Klotho protein protects against endothelial dysfunction.
Biochemical and biophysical research communications 1998;248(2):324-9.
1998: Inoue M; Kanda T; Arai M; McManus B M; Suzuki T; Kobayashi I; Nagai R
Impaired expression of atrial natriuretic peptide in diabetic rats with myocardial infarction.
Research communications in molecular pathology and pharmacology 1998;100(3):327-38.
1998: Iwami T; Nakamura T; Niwamae N; Yamagishi T; Utsugi T; Nagai R
Pre-clinical Cushing's syndrome with body weight loss and normal circadian rhythm of blood pressure.
Internal medicine (Tokyo, Japan) 1998;37(6):528-33.
1998: Hatori T; Iwasaki T; Seki R; Yamagishi T; Toyama T; Kaneko Y; Hasegawa A; Nagai R
[Technetium-99m (V) dimercaptosuccinic acid myocardial scintigraphy in a 74-year-old woman with congestive heart failure]
Journal of cardiology 1998;31(6):381-4.
1998: Akuzawa N; Nakamura T; Kurashina T; Saito Y; Hoshino J; Sakamoto H; Sumino H; Ono Z; Nagai R
Antihypertensive agents prevent nephrosclerosis and left ventricular hypertrophy induced in rats by prolonged inhibition of nitric oxide synthesis.
American journal of hypertension 1998;11(6 Pt 1):697-707.
1998: Suzuki T; Nagai R; Yazaki Y
Mechanisms of transcriptional regulation of gene expression in smooth muscle cells.
Circulation research 1998;82(12):1238-42.
1998: Matsumori A; Ohashi N; Hasegawa K; Sasayama S; Eto T; Imaizumi T; Izumi T; Kawamura K; Kawana M; Kimura A; Kitabatake A; Matsuzaki M; Nagai R; Tanaka H; Hiroe M; Hori M; Inoko H; Seko Y; Sekiguchi M; Shimotohno K; Sugishita Y; Takeda N; Takihara K; Tanaka M; Yokoyama M
Hepatitis C virus infection and heart diseases: a multicenter study in Japan.
Japanese circulation journal 1998;62(5):389-91.
1998: Takahashi T; Kanda T; Sumino H; Inoue M; Sato K; Sakamaki T; Kobayashi I; Iwamoto A; Nagai R
Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1998;197(6):319-28.
1998: Itoh T; Tanaka T; Nagai R; Kamiya T; Sawayama T; Nakayama T; Tomoike H; Sakurada H; Yazaki Y; Nakamura Y
Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.
Human genetics 1998;102(4):435-9.
1998: Nagai R; Hoshino Y
[Molecular genetics of cardiovascular diseases]
Rinsho byori. The Japanese journal of clinical pathology 1998;46(3):249-57.
1998: Iwasaki T; Iwasaki T; Oriuchi N; Endou K; Suzuki T; Katoh H; Nagai R
[Radioimmunoimaging of aortic dissection and acute bowel infarction with radiolabeled [correction of radioiodinated] murine antismooth muscle myosin antibody.
Journal of cardiology 1998;31(3):182-3.
1998: Shiraki-Iida T; Aizawa H; Matsumura Y; Sekine S; Iida A; Anazawa H; Nagai R; Kuro-o M; Nabeshima Y
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein.
FEBS letters 1998;424(1-2):6-10.
1998: Yamazaki T; Komuro I; Kudoh S; Zou Y; Nagai R; Aikawa R; Uozumi H; Yazaki Y
Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy.
Circulation research 1998;82(4):430-7.
1998: Arai M; Tomaru K; Takizawa T; Sekiguchi K; Yokoyama T; Suzuki T; Nagai R
Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits.
Journal of molecular and cellular cardiology 1998;30(2):243-54.
1998: Sumino H; Sato K; Sakamaki T; Masuda H; Nakamura T; Kanda T; Nagai R
Decreased basal production of nitric oxide in patients with heart disease.
Chest 1998;113(2):317-22.
1998: Kanda T; Kogure S; Nara M; Tsukui S; Utsugi T; Tomono S; Kawazu S; Nagai R; Kobayashi I
Combination of OK432 and human interferon-alpha for treating viral-induced diabetes mellitus in mice.
European journal of pharmacology 1998;342(2-3):297-302.
1998: Aizawa H; Hasegawa A; Arai M; Naganuma F; Hatori M; Kanda T; Suzuki T; Murata K; Satoh Y; Ishikawa S; Morishita Y; Nagai R
Bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis.
Internal medicine (Tokyo, Japan) 1998;37(1):56-9.
1998: Matsumura Y; Aizawa H; Shiraki-Iida T; Nagai R; Kuro-o M; Nabeshima Y
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
Biochemical and biophysical research communications 1998;242(3):626-30.
1998: Yamazaki T; Komuro I; Zou Y; Kudoh S; Shiojima I; Mizuno T; Hiroi Y; Nagai R; Yazaki Y
Efficient inhibition of the development of cardiac remodeling by a long-acting calcium antagonist amlodipine.
Hypertension 1998;31(1):32-8.
1998: Tamama K; Kanda T; Osada M; Nagai R; Suzuki T; Kobayashi I
Detection of left ventricular enlargement by electrocariography.
Journal of medicine 1998;29(3-4):231-6.
1998: Takahashi T; Kanda T; Inoue M; Sumino H; Kobayashi I; Iwamoto A; Nagai R
Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Life sciences 1998;63(10):PL137-43.
1998: Kanda T; Utsugi T; Kawazu S; Wilson J E; Yang D; Suarez A; McManus B M; Nagai R; Kobayashi I
Induction of virus-induced IDDM in virus resistant mice without lymphocyte maturation.
Life sciences 1998;63(1):33-40.
1998: Mise N; Kimura K; Nagai R; Ohba S; Suzuki N; Miyashita K; Tojo A; Goto A; Omata M
Mesangial expression of a nonmuscle myosin heavy chain, SMemb, is associated with glomerular sclerosis and renal prognosis in IgA nephropathy.
Nephron 1998;78(3):284-9.
1998: Nakamura T; Alberola A M; Salazar F J; Saito Y; Kurashina T; Granger J P; Nagai R
Effects of renal perfusion pressure on renal interstitial hydrostatic pressure and Na+ excretion: role of endothelium-derived nitric oxide.
Nephron 1998;78(1):104-11.
1997: Kuro-o M; Matsumura Y; Aizawa H; Kawaguchi H; Suga T; Utsugi T; Ohyama Y; Kurabayashi M; Kaname T; Kume E; Iwasaki H; Iida A; Shiraki-Iida T; Nishikawa S; Nagai R; Nabeshima Y I
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
Nature 1997;390(6655):45-51.
1997: Kowase K; Nakamura T; Okumura W; Okamoto E; Yamaguchi E; Sato H; Arai M; Imai S; Hasegawa A; Nagai R
Novel deletion on the short arm of chromosome 17 in a patient with multiple cardiac anomalies.
Japanese circulation journal 1997;61(10):882-5.
1997: Manabe I; Kurabayashi M; Shimomura Y; Kuro-o M; Watanabe N; Watanabe M; Aikawa M; Suzuki T; Yazaki Y; Nagai R
Isolation of the embryonic form of smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and characterization of its 5'-flanking region.
Biochemical and biophysical research communications 1997;239(2):598-605.
1997: Yamada S; Nishigori H; Onda H; Utsugi T; Yanagawa T; Maruyama T; Onigata K; Nagashima K; Nagai R; Morikawa A; Takeuchi T; Takeda J
Identification of mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene in Japanese subjects with IDDM.
Diabetes 1997;46(10):1643-7.
1997: Nakamura T; Saito Y; Kato T; Sumino H; Hoshino J; Ono Z; Sakamaki T; Nagai R
Flow-mediated vasodilation of a conduit artery in relation to downstream peripheral tissue blood flow during reactive hyperemia in humans.
Japanese circulation journal 1997;61(9):772-80.
1997: Sawada Y; Suda M; Yokoyama H; Kanda T; Sakamaki T; Tanaka S; Nagai R; Abe S; Takeuchi T
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
The Journal of biological chemistry 1997;272(33):20545-54.
1997: Kimura A; Harada H; Park J E; Nishi H; Satoh M; Takahashi M; Hiroi S; Sasaoka T; Ohbuchi N; Nakamura T; Koyanagi T; Hwang T H; Choo J A; Chung K S; Hasegawa A; Nagai R; Okazaki O; Nakamura H; Matsuzaki M; Sakamoto T; Toshima H; Koga Y; Imaizumi T; Sasazuki T
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy.
Nature genetics 1997;16(4):379-82.
1997: Sakamoto H; Sakamaki T; Kanda T; Hirao Y; Ohyama Y; Ogishi K; Negishi M; Masuda H; Sumino H; Sawada Y; Ono Z; Kobayashi I; Nagai R
Immunosuppressive drugs inhibit the production of interleukin-6 and interleukin-8 in cultured cardiac myxoma cells.
Research communications in molecular pathology and pharmacology 1997;97(1):60-6.
1997: Kaneko K; Kanda T; Yokoyama T; Nakazato Y; Iwasaki T; Kobayashi I; Nagai R
Expression of interleukin-6 in the ventricles and coronary arteries of patients with myocardial infarction.
Research communications in molecular pathology and pharmacology 1997;97(1):3-12.
1997: Iso T; Arai M; Wada A; Kogure K; Suzuki T; Nagai R
Humoral factor(s) produced by pressure overload enhance cardiac hypertrophy and natriuretic peptide expression.
The American journal of physiology 1997;273(1 Pt 2):H113-8.
1997: Aikawa M; Sakomura Y; Ueda M; Kimura K; Manabe I; Ishiwata S; Komiyama N; Yamaguchi H; Yazaki Y; Nagai R
Redifferentiation of smooth muscle cells after coronary angioplasty determined via myosin heavy chain expression.
Circulation 1997;96(1):82-90.
1997: Suzuki T; Kanda T; Nagaoka H; Kubota S; Iizuka T; Nagai R; Kobayashi I
Predictive value of left ventricular response to exercise in patients with dilated cardiomyopathy--assessment by radionuclide ventriculography.
Angiology 1997;48(6):497-502.
1997: Nakamura T; Ohyama Y; Masuda H; Kurashina T; Saito Y; Kato T; Sumino H; Sato K; Sakamaki T; Sasaki A; Nagai R
Chronic blockade of nitric oxide synthesis increases urinary endothelin-1 excretion.
Journal of hypertension 1997;15(4):373-81.
1997: Akuzawa N; Nakamura T; Tanaka A; Ikeda S; Fukuda T; Sakamaki T; Nagai R
Transient hypertension due to adrenal hemorrhage in a patient with von Recklinghausen's disease.
Internal medicine (Tokyo, Japan) 1997;36(4):289-92.
1997: Sato H; Toyama T; Kaneko Y; Nagai R; Tomiyoshi K; Inoue T; Endo K; Ota N; Kanazawa N; Suzuki T
[The usefulness of 18F-FDG SPECT imaging in evaluating myocardial viability]
Kaku igaku. The Japanese journal of nuclear medicine 1997;34(3):137-43.
1997: Nagaoka H; Isobe N; Kubota S; Iizuka T; Imai S; Suzuki T; Nagai R
Comparison of adenosine, dobutamine, and exercise radionuclide ventriculography in the detection of coronary artery disease.
Cardiology 1997;88(2):180-8.
1997: Hasegawa A; Hatori M; Amano M; Iijima T; Adachi H; Yamaguchi E; Fukuda T; Murata K; Nagai R
Adequacy of pacing rate during exercise in rate responsive ventricular pacing.
Pacing and clinical electrophysiology : PACE 1997;20(2 Pt 1):307-12.
1997: Tanaka T; Nagai R; Tomoike H; Takata S; Yano K; Yabuta K; Haneda N; Nakano O; Shibata A; Sawayama T; Kasai H; Yazaki Y; Nakamura Y
Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome.
Circulation 1997;95(3):565-7.
1997: Seta Y; Kanda T; Yokoyama T; Kobayashi I; Suzuki T; Nagai R
Effect of amrinone on murine viral myocarditis.
Research communications in molecular pathology and pharmacology 1997;95(1):57-66.
1997: Ishii C; Kawazu S; Utsugi T; Ito Y; Ohno T; Kato N; Tomono S; Nagai R; Komeda K
Change of plasma 1,5-anhydro-D-glucitol levels after the onset of diabetes in spontaneous diabetes prone BB/Wor/(/)Tky rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1997;29(1):9-11.
1997: Sawada Y; Inoue M; Kanda T; Sakamaki T; Tanaka S; Minamino N; Nagai R; Takeuchi T
Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats.
FEBS letters 1997;400(2):177-82.
1997: Sumino H; Kanda T; Kobayashi I; Sakamoto H; Sato K; Sakamaki T; Fukuda T; Ichikawa S; Nagai R
Reduced serum T3 level in a patient with nodular goiter and cardiac myxoma.
Journal of medicine 1997;28(5-6):319-24.
1996: Suzuki J; Isobe M; Aikawa M; Kawauchi M; Shiojima I; Kobayashi N; Tojo A; Suzuki T; Kimura K; Nishikawa T; Sakai T; Sekiguchi M; Yazaki Y; Nagai R
Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts. A study in rat and monkey models.
Circulation 1996;94(5):1118-24.
1996: Arai M; Suzuki T; Nagai R
Sarcoplasmic reticulum genes are upregulated in mild cardiac hypertrophy but downregulated in severe cardiac hypertrophy induced by pressure overload.
Journal of molecular and cellular cardiology 1996;28(8):1583-90.
1996: Kimura K; Suzuki N; Ohba S; Nagai R; Hiroi J; Mise N; Tojo A; Nagaoka A; Hirata Y; Goto A; Yazaki Y; Omata M
Hypertensive glomerular damage as revealed by the expression of alpha-smooth muscle actin and non-muscle myosin.
Kidney international. Supplement 1996;55():S169-72.
1996: Toyama T; Hoshizaki H; Isobe N; Ohshima S; Taniguchi K; Suzuki Y; Suzuki T; Nagai R; Endo K
[The regional wall motion and the myocardial fatty acid metabolism at hibernating myocardium]
Kaku igaku. The Japanese journal of nuclear medicine 1996;33(6):607-15.
1996: Watanabe M; Sakomura Y; Kurabayashi M; Manabe I; Aikawa M; Kuro-o M; Suzuki T; Yazaki Y; Nagai R
Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene.
Circulation research 1996;78(6):978-89.
1996: Sato K; Sumino H; Sakamaki T; Sakamoto H; Nakamura T; Ono Z; Nagai R
Lack of inhibitory effect of dexamethasone on exhalation of nitric oxide by healthy humans.
Internal medicine (Tokyo, Japan) 1996;35(5):356-61.
1996: Hiroi J; Kimura K; Aikawa M; Tojo A; Suzuki Y; Nagamatsu T; Omata M; Yazaki Y; Nagai R
Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats.
Kidney international 1996;49(5):1231-41.
1996: Kanda T; McManus J E; Nagai R; Imai S; Suzuki T; Yang D; McManus B M; Kobayashi I
Modification of viral myocarditis in mice by interleukin-6.
Circulation research 1996;78(5):848-56.
1996: Nagaoka H; Kubota S; Iizuka T; Imai S; Nagai R
Relation between depressed cardiac response to exercise and autonomic nervous activity in mildly symptomatic patients with idiopathic dilated cardiomyopathy.
Chest 1996;109(4):925-32.
1996: Nakajima T; Kaneko Y; Taniguchi Y; Nagai R
[Long QT syndrome]
Nippon rinsho. Japanese journal of clinical medicine 1996;54(3):776-81.
1996: Suzuki T; Katoh H; Watanabe M; Kurabayashi M; Hiramori K; Hori S; Nobuyoshi M; Tanaka H; Kodama K; Sato H; Suzuki S; Tsuchio Y; Yazaki Y; Nagai R
Novel biochemical diagnostic method for aortic dissection. Results of a prospective study using an immunoassay of smooth muscle myosin heavy chain.
Circulation 1996;93(6):1244-9.
1996: Suzuki T; Kim H S; Kurabayashi M; Hamada H; Fujii H; Aikawa M; Watanabe M; Watanabe N; Sakomura Y; Yazaki Y; Nagai R
Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2.
Circulation research 1996;78(3):395-404.
1996: Takahashi T; Kanda T; Imai S; Suzuki T; Kobayashi I; Nagai R
Amlodipine inhibits the development of right ventricular hypertrophy and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Research communications in molecular pathology and pharmacology 1996;91(1):17-32.
1996: Suzuki T; Aikawa M; Kuro-o M; Watanabe M; Kimura K; Yazaki Y; Nagai R
Presence of contractile-type smooth muscle cells in the endocardium.
Cardiology 1996;87(1):23-7.
1996: Okamoto E; Suzuki T; Aikawa M; Imataka K; Fujii J; Kuro-o M; Nakahara K; Hasegawa A; Yazaki Y; Nagai R
Diversity of the synthetic-state smooth-muscle cells proliferating in mechanically and hemodynamically injured rabbit arteries.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):120-8.
1996: Takahashi T; Kanda T; Inoue M; Suzuki T; Kobayashi I; Kodama K; Nagai R
A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Life sciences 1996;59(23):PL 371-7.
1996: Kanda T; Sakamoto H; McManus B M; Sakamaki T; Nagai R; Suzuki T; Kobayashi I
Interleukin-6 secreted from human myxoma reduces murine viral myocarditis.
Life sciences 1996;58(20):1705-12.
1995: Sakamaki T; Sato K; Mochida M; Saito Y; Oyama Y; Nagai R; Ikeno M; Ishikawa T
Synthetic N omega-hydroxy-L-arginine causes endothelium-dependent vascular relaxation both in vitro and in vivo.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 1995;31(6):439-43.
1995: Oyama Y; Sakamaki T; Masuda H; Sumino H; Mochida M; Sakamoto K; Nakamura T; Sato K; Ono Z; Nagai R
[Effect of lipopolysaccharide on nitric oxide synthase family (neural NOS, endothelial NOS and inducible NOS)]
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 1995;31(6):435-6.
1995: Suzuki Y; Toyama T; Kanda T; Tsukagoshi J; Isobe N; Nagaoka H; Kubota S; Iizuka T; Imai S; Nagai R
[Prognostic significance of 123I-metaiodobenzylguanidine scintigraphy in dilated cardiomyopathy]
Kaku igaku. The Japanese journal of nuclear medicine 1995;32(11):1207-15.
1995: Seko Y; Azuma M; Yagita H; Okumura K; Hirai H; Nagai R; Yazaki Y
Perforin-positive leukemic cell infiltration in the heart of a patient with T-cell prolymphocytic leukemia.
Internal medicine (Tokyo, Japan) 1995;34(8):782-4.
1995: Kimura K; Nagai R; Sakai T; Aikawa M; Kuro-o M; Kobayashi N; Shirato I; Inagami T; Oshi M; Suzuki N
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isoform expression.
Kidney international 1995;48(2):372-82.
1995: Kurihara Y; Kurihara H; Oda H; Maemura K; Nagai R; Ishikawa T; Yazaki Y
Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.
The Journal of clinical investigation 1995;96(1):293-300.
1995: Komuro I; Yamazaki T; Katoh Y; Tobe K; Kadowaki T; Nagai R; Yazaki Y
Protein kinase cascade activated by mechanical stress in cardiocytes: possible involvement of angiotensin II.
European heart journal 1995;16 Suppl C():8-11.
1995: Nagai R; Kuro-o M; Aikawa M; Watanabe M; Suzuki T; Yazaki Y
[Smooth muscle myosin heavy chain expression in the arterial wall; a new viewpoint for vascular pathology]
Rinsho byori. The Japanese journal of clinical pathology 1995;43(4):337-41.
1995: Nagai R; Miyazawa K
[Molecular biology in cardiovascular medicine]
Rinsho byori. The Japanese journal of clinical pathology 1995;43(4):335-6.
1995: Kuro-o M; Hanaoka K; Hiroi Y; Noguchi T; Fujimori Y; Takewaki S; Hayasaka M; Katoh H; Miyagishi A; Nagai R
Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger.
Circulation research 1995;76(1):148-53.
1995: Aikawa M; Kim H S; Kuro-o M; Manabe I; Watanabe M; Yamaguchi H; Yazaki Y; Nagai R
Phenotypic modulation of smooth muscle cells during progression of human atherosclerosis as determined by altered expression of myosin heavy chain isoforms.
Annals of the New York Academy of Sciences 1995;748():578-85.
1995: Aikawa M; Yamaguchi H; Yazaki Y; Nagai R
Smooth muscle phenotypes in developing and atherosclerotic human arteries demonstrated by myosin expression.
Journal of atherosclerosis and thrombosis 1995;2(1):14-23.
1994: Morita T; Kurihara H; Maemura K; Yoshizumi M; Nagai R; Yazaki Y
Role of Ca2+ and protein kinase C in shear stress-induced actin depolymerization and endothelin 1 gene expression.
Circulation research 1994;75(4):630-6.
1994: Maemura K; Kurihara H; Kurihara Y; Nagai R; Yazaki Y
Isolation and characterization of vascular endothelial cells derived from mice lacking endothelin-1.
Biochemical and biophysical research communications 1994;201(2):538-45.
1994: Kurihara Y; Kurihara H; Suzuki H; Kodama T; Maemura K; Nagai R; Oda H; Kuwaki T; Cao W H; Kamada N
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.
Nature 1994;368(6473):703-10.
1994: Suzuki T; Nagai R; Yamazaki T; Shiojima I; Maemura K; Yamaoki K; Tanaka N; Machida T; Kotsuka Y; Furuse A
Rapid growth of intracranial aneurysms secondary to cardiac myxoma.
Neurology 1994;44(3 Pt 1):570-1.
1994: Suzuki T; Nagai R; Kurihara H; Kurihara Y; Yamazaki T; Ho E; Maemura K; Shiojima I; Yamaoki K; Furuse A
Stenotic bicuspid aortic valve associated with a ventricular septal defect in an adult presenting with congestive heart failure: a rare observation.
European heart journal 1994;15(3):402-3.
1994: Takewaki S; Okuzumi K; Manabe I; Tanimura M; Miyamura K; Nakahara K; Yazaki Y; Ohkubo A; Nagai R
Nucleotide sequence comparison of the mycobacterial dnaJ gene and PCR-restriction fragment length polymorphism analysis for identification of mycobacterial species.
International journal of systematic bacteriology 1994;44(1):159-66.
1993: Morita T; Yoshizumi M; Kurihara H; Maemura K; Nagai R; Yazaki Y
Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells.
Biochemical and biophysical research communications 1993;197(1):256-62.
1993: Kim H S; Aikawa M; Kimura K; Kuro-o M; Nakahara K; Suzuki T; Katoh H; Okamoto E; Yazaki Y; Nagai R
Ductus arteriosus. Advanced differentiation of smooth muscle cells demonstrated by myosin heavy chain isoform expression in rabbits.
Circulation 1993;88(4 Pt 1):1804-10.
1993: Kuro-o M; Nagai R; Yazaki Y; Hanaoka K; Nabeshima Y
[Production of transgenic mice overexpressing rabbit Na+/H+ antiporter]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(6):1524-9.
1993: Takewaki S; Nagai R
[Activation of Na(+)-H+ antiporter gene expression during vascular smooth muscle proliferation and cardiac hypertrophy]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(6):1518-23.
1993: Yamazaki T; Tobe K; Hoh E; Maemura K; Kaida T; Komuro I; Tamemoto H; Kadowaki T; Nagai R; Yazaki Y
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
The Journal of biological chemistry 1993;268(16):12069-76.
1993: Nagai R
[Molecular basis for heart failure]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(5):1217-21.
1993: Isobe M; Yamaoki K; Sugiyama T; Seko Y; Yoshizumi M; Nagai R; Yazaki Y
Right ventricular inflow obstruction due to giant hematoma formed by chronic constrictive pericarditis.
Internal medicine (Tokyo, Japan) 1993;32(4):346-9.
1993: Nagai R; Yamazaki T; Shiojima I; Yazaki Y
[Molecular basis for cardiac functions]
Rinsho byori. The Japanese journal of clinical pathology 1993;41(4):409-14.
1993: Takewaki S; Okuzumi K; Ishiko H; Nakahara K; Ohkubo A; Nagai R
Genus-specific polymerase chain reaction for the mycobacterial dnaJ gene and species-specific oligonucleotide probes.
Journal of clinical microbiology 1993;31(2):446-50.
1993: Yazaki Y; Komuro I; Yamazaki T; Tobe K; Maemura K; Kadowaki T; Nagai R
Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes.
Molecular and cellular biochemistry 1993;119(1-2):11-6.
1993: Morita T; Kurihara H; Yoshizumi M; Maemura K; Sugiyama T; Nagai R; Yazaki Y
Human polymorphonuclear leukocytes have dual effects on endothelin-1: the induction of endothelin-1 mRNA expression in vascular endothelial cells and modification of the endothelin-1 molecule.
Heart and vessels 1993;8(1):1-6.
1993: Yamazaki T; Seko Y; Nagai R; Yazaki Y
[Roles of cell-adhesion molecules in myocardial reperfusion injury]
Japanese circulation journal 1993;57 Suppl 4():1344-6.
1992: Nakahara K; Nishimura H; Kuro-o M; Takewaki S; Iwase M; Ohkubo A; Yazaki Y; Nagai R
Identification of three types of PDGF-A chain gene transcripts in rabbit vascular smooth muscle and their regulated expression during development and by angiotensin II.
Biochemical and biophysical research communications 1992;184(2):811-8.
1992: Shiojima I; Komuro I; Ieki K; Nagai R; Yazaki Y
[Molecular mechanism of diastolic dysfunction in pressure overload cardiac hypertrophy]
Japanese circulation journal 1992;56 Suppl 5():1268-72.
1991: Nagai R; Yazaki Y
[Biochemical diagnosis for acute myocardial infarction; myosin light chain]
Rinsho byori. The Japanese journal of clinical pathology 1991;39(11):1161-5.
1991: Kuro-o M; Nagai R; Nakahara K; Katoh H; Tsai R C; Tsuchimochi H; Yazaki Y; Ohkubo A; Takaku F
cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis.
The Journal of biological chemistry 1991;266(6):3768-73.
1990: Nagai R; Takewaki S; Wada A; Okuzumi K; Tobita A; Ohkubo A
[Rapid detection and identification of mycobacterial DNA by PCR]
Rinsho byori. The Japanese journal of clinical pathology 1990;38(11):1247-53.
1990: Isobe M; Nagai R; Takaku F; Yamaguchi T; Yazaki Y
[Reduction of myocardial infarct size by early intracoronary thrombolysis as assessed by serum cardiac myosin light chains and left ventricular function]
Journal of cardiology 1990;20(3):521-30.
1989: Kuro-o M; Nagai R; Tsuchimochi H; Katoh H; Yazaki Y; Ohkubo A; Takaku F
Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms.
The Journal of biological chemistry 1989;264(31):18272-5.
1989: Isobe M; Nagai R; Yamaoki K; Nakaoka H; Takaku F; Yazaki Y
Quantification of myocardial infarct size after coronary reperfusion by serum cardiac myosin light chain II in conscious dogs.
Circulation research 1989;65(3):684-94.
1989: Isobe M; Nagai R; Takaku F; Yazaki Y
Infarct sizing after reperfusion by two-dimensional echocardiography and serum cardiac myosin light chain II in conscious dogs: dissociation between early left ventricular wall motion and ultimate infarct size.
Japanese circulation journal 1989;53(9):1100-7.
1989: Kurihara H; Yamaoki K; Nagai R; Yoshizumi M; Takaku F; Satoh H; Inui J; Yazaki Y
Endothelin: a potent vasoconstrictor associated with coronary vasospasm.
Life sciences 1989;44(25):1937-43.
1989: Kurihara H; Yoshizumi M; Sugiyama T; Yamaoki K; Nagai R; Takaku F; Satoh H; Inui J; Yanagisawa M; Masaki T
The possible role of endothelin-1 in the pathogenesis of coronary vasospasm.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S132-7; discussion S142.
1987: Isobe M; Nagai R; Ueda S; Tsuchimochi H; Nakaoka H; Takaku F; Yamaguchi T; Machii K; Nobuyoshi M; Yazaki Y
Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary reperfusion in patients with acute myocardial infarction.
Circulation 1987;76(6):1251-61.

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