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Tsuneji Nagai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

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Pharmaceutical Chemistry

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Co-Publications
Name
75
Takayama, Kozo
50
Maitani, Yoshie
33
Machida, Yoshiharu
13
Qi, Xian-rong
12
Morishita, Mariko
11
Isowa, Koichi
11
Obata, Yasuko
11
Onishi, Hiraku
11
Ueda, Haruhisa
7
Higashiyama, Kimio
6
Chiba, Yoshiyuki
6
Tokiwa, Shinji
6
Zhang, Qiang
5
Shimizu, Kazuyuki
4
Takayama, Kozo

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Publications

TOP 3
Li Yuan; Qi Xian Rong; Maitani Yoshie; Nagai Tsuneji
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.
Ma Hui Li; Xu Yu Feng; Qi Xian Rong; Maitani Yoshie; Nagai Tsuneji
Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.
Ma Hui-Li; Qi Xian-Rong; Ding Wu-Xiao; Maitani Yoshie; Nagai Tsuneji
Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles.

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All Publications

2009: Li Yuan; Qi Xian Rong; Maitani Yoshie; Nagai Tsuneji
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.
Nanotechnology 2009;20(5):55106.
2008: Ma Hui Li; Xu Yu Feng; Qi Xian Rong; Maitani Yoshie; Nagai Tsuneji
Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.
International journal of pharmaceutics 2008;354(1-2):217-26.
2008: Ma Hui-Li; Qi Xian-Rong; Ding Wu-Xiao; Maitani Yoshie; Nagai Tsuneji
Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles.
Journal of biomedical materials research. Part A 2008;84(3):598-606.
2007: Ma Hui-li; Qi Xian-rong; Maitani Yoshie; Nagai Tsuneji
Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate.
International journal of pharmaceutics 2007;333(1-2):177-86.
2007: Zhang Yuan; Rong Qi Xian; Gao Yan; Wei Lai; Maitani Yoshie; Nagai Tsuneji
Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(2):281-90.
2006: Feng Li; Qi Xian Rong; Zhou Xing Jun; Maitani Yoshie; Wang Shi Cong; Jiang Yang; Nagai Tsuneji
Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):35-42.
2006: Nagai Tsuneji
Future DDS by qualified science of science for hybrid, hi-quality and husbandry.
Journal of drug targeting 2006;14(7):446-7.
2005: Shi Jing; Yan Wen-Wei; Qi Xian-Rong; Maitani Yoshie; Nagai Tsuneji
Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide.
Drug delivery 2005;12(6):349-56.
2005: Xiong Xiao-Bing; Huang Yue; Lu Wan-Liang; Zhang Xuan; Zhang Hua; Nagai Tsuneji; Zhang Qiang
Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):262-75.
2005: Xiong Xiao-Bing; Huang Yue; Lu Wan-Liang; Zhang Xuan; Zhang Hua; Nagai Tsuneji; Zhang Qiang
Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: in vitro and in vivo.
Journal of pharmaceutical sciences 2005;94(8):1782-93.
2005: Ding Wu-Xiao; Qi Xian-Rong; Li Ping; Maitani Yoshie; Nagai Tsuneji
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
International journal of pharmaceutics 2005;300(1-2):38-47.
2005: Lau Kent G; Hattori Yoshiyuki; Chopra Sunil; O'Toole Edel A; Storey Alan; Nagai Tsuneji; Maitani Yoshie
Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.
International journal of pharmaceutics 2005;300(1-2):4-12.
2005: Xie Ying; Ye Liya; Zhang Xiaobin; Cui Wei; Lou Jinning; Nagai Tsuneji; Hou Xinpu
Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studies.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(1-2):106-19.
2004: Dai Jundong; Nagai Tsuneji; Wang Xueqing; Zhang Tao; Meng Meng; Zhang Qiang
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A.
International journal of pharmaceutics 2004;280(1-2):229-40.
2004: Wang Xue-Qing; Dai Jun-Dong; Chen Zhen; Zhang Tao; Xia Gui-Min; Nagai T; Zhang Qiang
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(3):421-9.
2004: Xiao Chaoju; Qi Xianrong; Maitani Yoshie; Nagai Tsuneji
Sustained release of cisplatin from multivesicular liposomes: potentiation of antitumor efficacy against S180 murine carcinoma.
Journal of pharmaceutical sciences 2004;93(7):1718-24.
2004: Takayama K; Obata Y; Morishita M; Nagai T
Multivariate spline interpolation as a novel method to optimize pharmaceutical formulations.
Die Pharmazie 2004;59(5):392-5.
2004: Morishita Mariko; Aoki Yoshinobu; Sakagami Masahiro; Nagai Tsuneji; Takayama Kozo
In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers.
Pharmaceutical research 2004;21(2):309-16.
2004: Shiraki Masataka; Fukuchi Masayuki; Kiriyama Takeshi; Okamoto Sumiaki; Ueno Takehisa; Sakamoto Hiroshi; Nagai Tsuneji
Alfacalcidol reduces accelerated bone turnover in elderly women with osteoporosis.
Journal of bone and mineral metabolism 2004;22(4):352-9.
2003: Miyazaki Yasunori; Ogihara Kanako; Yakou Shigeru; Nagai Tsuneji; Takayama Kozo
Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.
Biological & pharmaceutical bulletin 2003;26(12):1744-7.
2003: Hendradi Esti; Obata Yasuko; Isowa Koichi; Nagai Tsuneji; Takayama Kozo
Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac.
Biological & pharmaceutical bulletin 2003;26(12):1739-43.
2003: Miyazaki Yasunori; Yakou Shigeru; Nagai Tsuneji; Takayama Kozo
The effect of polyion complex formation on in vitro/in vivo correlation of hydrophilic matrix tablets.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(3):315-26.
2003: Miyazaki Yasunori; Yakou Shigeru; Nagai Tsuneji; Takayama Kozo
Release profiles of theophylline from microspheres consisting of dextran derivatives and cellulose acetate butyrate: effect of polyion complex formation.
Drug development and industrial pharmacy 2003;29(7):795-804.
2003: Katayama Ken; Kato Yoshinori; Onishi Hiraku; Nagai Tsuneji; Machida Yoshiharu
Double liposomes: hypoglycemic effects of liposomal insulin on normal rats.
Drug development and industrial pharmacy 2003;29(7):725-31.
2003: Surini Silvia; Akiyama Hidero; Morishita Mariko; Nagai Tsuneji; Takayama Kozo
Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate.
Journal of controlled release : official journal of the Controlled Release Society 2003;90(3):291-301.
2003: Li Chao Jie; Obata Yasuko; Higashiyama Kimio; Nagai Tsuneji; Takayama Kozo
Effect of 1-O-ethyl-3-butylcyclohexanol on the skin permeation of drugs with different physicochemical characteristics.
International journal of pharmaceutics 2003;259(1-2):193-8.
2003: Miyazaki Yasunori; Ogihara Kanako; Yakou Shigeru; Nagai Tsuneji; Takayama Kozo
In vitro and in vivo evaluation of mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.
International journal of pharmaceutics 2003;258(1-2):21-9.
2003: Yoshino Tomoaki; Machida Yoshiharu; Onishi Hiraku; Nagai Tsuneji
Preparation and characterization of chitosan microspheres containing doxifluridine.
Drug development and industrial pharmacy 2003;29(4):417-27.
2003: Nagai Tsuneji
[Pharmacy, pharmacists and society--pharmaceutical science and practice with philosophy]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2003;123(3):143-50.
2003: Kawano Kumi; Takayama Kozo; Nagai Tsuneji; Maitani Yoshie
Preparation and pharmacokinetics of pirarubicin loaded dehydration-rehydration vesicles.
International journal of pharmaceutics 2003;252(1-2):73-9.
2003: Nakamura Koji; Takayama Kozo; Nagai Tsuneji; Maitani Yoshie
Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats.
Journal of pharmaceutical sciences 2003;92(2):311-8.
2003: Junping Wang; Takayama Kozo; Nagai Tsuneji; Maitani Yoshie
Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol.
International journal of pharmaceutics 2003;251(1-2):13-21.
2002: Ishikawa Osamu; Kato Yoshinori; Onishi Hiraku; Nagai Tsuneji; Machida Yoshiharu
Enhancement of transdermal absorption by switching iontophoresis.
International journal of pharmaceutics 2002;249(1-2):81-8.
2002: Katayama Ken; Kato Yoshinori; Onishi Hiraku; Nagai Tsuneji; Machida Yoshiharu
Preparation of novel double liposomes using the glass-filter method.
International journal of pharmaceutics 2002;248(1-2):93-9.
2002: Asai Kazunori; Morishita Mariko; Katsuta Hideo; Hosoda Shoji; Shinomiya Katsuhiko; Noro Masahiro; Nagai Tsuneji; Takayama Kozo
The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa.
International journal of pharmaceutics 2002;246(1-2):25-35.
2002: Kawano Kumi; Nakamura Kouji; Hayashi Kyoko; Nagai Tsuneji; Takayama Kozo; Maitani Yoshie
Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells.
Biological & pharmaceutical bulletin 2002;25(6):766-70.
2002: Tsutsumi Keiko; Obata Yasuko; Nagai Tsuneji; Loftsson Thorsteinn; Takayama Kozo
Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs.
International journal of pharmaceutics 2002;238(1-2):161-70.
2002: Morishita Mariko; Lowman Anthony M; Takayama Kozo; Nagai Tsuneji; Peppas Nicholas A
Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):25-32.
2001: Li C J; Higashiyama K; Yoshimura Y; Nagai T; Takayama K; Obata Y
Promoting mechanism of menthol derivative, 1-O-ethyl-3-buthylcyclohexanol, on the percutaneous absorption of ketoprofen.
Biological & pharmaceutical bulletin 2001;24(9):1044-8.
2001: Maitani Y; Kawano K; Yamada K; Nagai T; Takayama K
Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):381-9.
2001: Zhang Q; Shen Z; Nagai T
Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats.
International journal of pharmaceutics 2001;218(1-2):75-80.
2001: Morishita M; Barichello J M; Takayama K; Chiba Y; Tokiwa S; Nagai T
Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin.
International journal of pharmaceutics 2001;212(2):289-93.
2001: Obata Y; Li C J; Fujikawa M; Takayama K; Sato H; Higashiyama K; Isowa K; Nagai T
Evaluation and structure-activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network.
International journal of pharmaceutics 2001;212(2):223-31.
2000: Qi X R; Maitani Y; Hou X P; Zhang Q; Wei S L; Nagai T
[Interactions of insulin with dipalmitoylphosphatidylcholine liposomes]
Yao xue xue bao = Acta pharmaceutica Sinica 2000;35(12):924-8.
2000: Kajita M; Morishita M; Takayama K; Chiba Y; Tokiwa S; Nagai T
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid.
Journal of pharmaceutical sciences 2000;89(10):1243-52.
2000: Junping W; Maitani Y; Takayama K; Nagai T
In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome.
International journal of pharmaceutics 2000;203(1-2):61-9.
2000: Takayama K; Morva A; Fujikawa M; Hattori Y; Obata Y; Nagai T
Formula optimization of theophylline controlled-release tablet based on artificial neural networks.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(2):175-86.
2000: Wang J P; Maitani Y; Takayama K; Nagai T
Pharmacokinetics and antitumor effect of doxorubicin carried by stealth and remote loading proliposome.
Pharmaceutical research 2000;17(7):782-7.
2000: Iwase H; Sudo J; Terui J; Kakuno K; Watanabe T; Takayama K; Nagai T
Transdermal absorption of L-dopa from a new system composed of two separate layers of L-dopa and hydrogel in rats.
Drug development and industrial pharmacy 2000;26(7):755-9.
2000: Morishita M; Kajita M; Suzuki A; Takayama K; Chiba Y; Tokiwa S; Nagai T
The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA.
International journal of pharmaceutics 2000;201(2):175-85.
2000: Muramatsu K; Masumizu T; Maitani Y; Hwang S H; Kohno M; Takayama K; Nagai T
Electron spin resonance studies of dipalmitoylphosphatidylcholine liposomes containing soybean-derived sterylglucoside.
Chemical & pharmaceutical bulletin 2000;48(5):610-3.
2000: Maitani Y; Nakamura K; Suenaga H; Kamata K; Takayama K; Nagai T
The enhancing effect of soybean-derived sterylglucoside and beta-sitosterol beta-D-glucoside on nasal absorption in rabbits.
International journal of pharmaceutics 2000;200(1):17-26.
2000: Obata Y; Sato H; Li C J; Takayama K; Higashiyama K; Nagai T; Isowa K
Effect of synthesized cyclohexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen.
International journal of pharmaceutics 2000;198(2):191-200.
2000: Onuki Y; Morishita M; Takayama K; Tokiwa S; Chiba Y; Isowa K; Nagai T
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
International journal of pharmaceutics 2000;198(2):147-56.
2000: Obata Y; Sesumi T; Takayama K; Isowa K; Grosh S; Wick S; Sitz R; Nagai T
Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis.
Journal of pharmaceutical sciences 2000;89(4):556-61.
2000: Hwang S H; Maitani Y; Takayama K; Nagai T
High entrapment of insulin and bovine serum albumin into neutral and positively-charged liposomes by the remote loading method.
Chemical & pharmaceutical bulletin 2000;48(3):325-9.
1999: Takayama K; Takahara J; Fujikawa M; Ichikawa H; Nagai T
Formula optimization based on artificial neural networks in transdermal drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):161-70.
1999: Muramatsu K; Maitani Y; Takayama K; Nagai T
The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits.
Drug development and industrial pharmacy 1999;25(10):1099-105.
1999: Nakamura K; Maitani Y; Lowman A M; Takayama K; Peppas N A; Nagai T
Uptake and release of budesonide from mucoadhesive, pH-sensitive copolymers and their application to nasal delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(3):329-35.
1999: Ueda H; Wakamiya A; Endo T; Nagase H; Tomono K; Nagai T
Interaction of cyclomaltononaose (delta-CD) with several drugs.
Drug development and industrial pharmacy 1999;25(8):951-4.
1999: Maitani Y; Moriya H; Shimoda N; Takayama K; Nagai T
Distribution characteristics of entrapped recombinant human erythropoietin in liposomes and its intestinal absorption in rats.
International journal of pharmaceutics 1999;185(1):13-22.
1999: Barichello J M; Morishita M; Takayama K; Nagai T
Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats.
International journal of pharmaceutics 1999;184(2):189-98.
1999: Barichello J M; Morishita M; Takayama K; Chiba Y; Tokiwa S; Nagai T
Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids.
International journal of pharmaceutics 1999;183(2):125-32.
1999: Barichello J M; Morishita M; Takayama K; Nagai T
Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method.
Drug development and industrial pharmacy 1999;25(4):471-6.
1999: Hwang S H; Maitani Y; Qi X R; Takayama K; Nagai T
Remote loading of diclofenac, insulin and fluorescein isothiocyanate labeled insulin into liposomes by pH and acetate gradient methods.
International journal of pharmaceutics 1999;179(1):85-95.
1999: Tsutsumi K; Obata Y; Takayama K; Isowa K; Nagai T
Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch.
International journal of pharmaceutics 1999;177(1):7-14.
1999: Takanashi Y; Higashiyama K; Komiya H; Takayama K; Nagai T
Thiomenthol derivatives as novel percutaneous absorption enhancers.
Drug development and industrial pharmacy 1999;25(1):89-94.
1999: Takayama K; Fujikawa M; Nagai T
Artificial neural network as a novel method to optimize pharmaceutical formulations.
Pharmaceutical research 1999;16(1):1-6.
1998: Sudo J; Iwase H; Terui J; Kakuno K; Soyama M; Takayama K; Nagai T
Transdermal absorption of L-dopa from hydrogel in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;7(1):67-71.
1998: Suzuki A; Morishita M; Kajita M; Takayama K; Isowa K; Chiba Y; Tokiwa S; Nagai T
Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid.
Journal of pharmaceutical sciences 1998;87(10):1196-202.
1998: Ueda H; Ou D; Endo T; Nagase H; Tomono K; Nagai T
Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs.
Drug development and industrial pharmacy 1998;24(9):863-7.
1998: Tsutsumi K; Obata Y; Takayama K; Loftsson T; Nagai T
Effect of cod-liver oil extract on the buccal permeation of ergotamine tartrate.
Drug development and industrial pharmacy 1998;24(8):757-62.
1998: Yamamoto T; Maitani Y; Ando T; Isowa K; Takayama K; Nagai T
High absorbency and subchronic morphologic effects on the nasal epithelium of a nasal insulin powder dosage form with a soybean-derived sterylglucoside mixture in rabbits.
Biological & pharmaceutical bulletin 1998;21(8):866-70.
1998: Ando T; Maitani Y; Yamamoto T; Takayama K; Nagai T
Nasal insulin delivery in rabbits using soybean-derived sterylglucoside and sterol mixtures as novel enhancers in suspension dosage forms.
Biological & pharmaceutical bulletin 1998;21(8):862-5.
1998: Shimizu K; Maitani Y; Takahashi N; Takayama K; Nagai T
Association of liposomes containing a soybean-derived sterylglucoside mixture with rat primary cultured hepatocytes.
Biological & pharmaceutical bulletin 1998;21(8):818-22.
1998: Shimizu K; Qi X R; Maitani Y; Yoshii M; Kawano K; Takayama K; Nagai T
Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mouse models.
Biological & pharmaceutical bulletin 1998;21(7):741-6.
1998: Yamane S; Takayama K; Nagai T
Effect of fractal dimension on drug permeation through porous ethylcellulose films.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):103-9.
1997: Moriya H; Maitani Y; Shimoda N; Takayama K; Nagai T
Pharmacokinetic and pharmacological profiles of free and liposomal recombinant human erythropoietin after intravenous and subcutaneous administrations in rats.
Pharmaceutical research 1997;14(11):1621-8.
1997: Nagai T
[New drug development by innovative drug administration--"change" in pharmaceutical field]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(10-11):963-71.
1997: Shimizu K; Maitani Y; Takayama K; Nagai T
Formulation of liposomes with a soybean-derived sterylglucoside mixture and cholesterol for liver targeting.
Biological & pharmaceutical bulletin 1997;20(8):881-6.
1996: Sato M; Onishi H; Takahara J; Machida Y; Nagai T
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(9):1170-7.
1996: Muramatsu K; Maitani Y; Nagai T
Dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols and cholesterol as a carrier for the oral administration of insulin in rats.
Biological & pharmaceutical bulletin 1996;19(8):1055-8.
1996: Shimizu K; Maitani Y; Takayama K; Nagai T
Characterization of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture by differential scanning calorimetry, Fourier transform infrared spectroscopy, and enzymatic assay.
Journal of pharmaceutical sciences 1996;85(7):741-4.
1996: Maitani Y; Hazama M; Tojo Y; Shimoda N; Nagai T
Oral administration of recombinant human erythropoietin in liposomes in rats: influence of lipid composition and size of liposomes on bioavailability.
Journal of pharmaceutical sciences 1996;85(4):440-5.
1996: Maitani Y; Shimada K; Nagai T
l-Menthol, oleic acid and lauricidin in absorption enhancement of free and sodium salt of diclofenac using ethanol treated silicone membrane as model for skin.
Chemical & pharmaceutical bulletin 1996;44(2):403-8.
1996: Sato M; Onishi H; Kitano M; Machida Y; Nagai T
Preparation and drug release characteristics of the conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(2):241-5.
1996: Shimizu K; Maitani Y; Takayama K; Nagai T
Evaluation of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture for liver targeting.
Journal of drug targeting 1996;4(4):245-53.
1995: Matsuzawa A; Morishita M; Takayama K; Nagai T
Absorption of insulin using water-in-oil-in-water emulsion from an enteral loop in rats.
Biological & pharmaceutical bulletin 1995;18(12):1718-23.
1995: Maitani Y; Hazama M; Tojo H; Qi X R; Nagai T
Effects of orally administered liposomes with soybean-derived sterols and their glucosides on rat body weight.
Biological & pharmaceutical bulletin 1995;18(11):1551-5.
1995: Yamamoto T; Maitani Y; Isowa K; Nagai T
Morphologic examination of rabbit nasal mucosa after the nasal administration of insulin peanut oil suspension and a powder dosage form with soybean-derived sterylglucoside.
Biological & pharmaceutical bulletin 1995;18(6):887-90.
1995: Shimoda N; Maitani Y; Machida Y; Nagai T
Effects of dose, pH and osmolarity on intranasal absorption of recombinant human erythropoietin in rats.
Biological & pharmaceutical bulletin 1995;18(5):734-9.
1995: Ohara N; Takayama K; Nagai T
Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs.
Biological & pharmaceutical bulletin 1995;18(3):439-42.
1995: Qi X R; Maitani Y; Shimoda N; Sakaguchi K; Nagai T
Evaluation of liposomal erythropoietin prepared with reverse-phase evaporation vesicle method by subcutaneous administration in rats.
Chemical & pharmaceutical bulletin 1995;43(2):295-9.
1995: Qi X R; Maitani Y; Nagai T
Rates of systemic degradation and reticuloendothelial system uptake of calcein in the dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols in mice.
Pharmaceutical research 1995;12(1):49-52.
1994: Levison K K; Takayama K; Isowa K; Okabe K; Nagai T
Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers.
Journal of pharmaceutical sciences 1994;83(9):1367-72.
1993: Maitani Y; Kugo M; Nakagaki M; Nagai T
Ionic size and behavior of diclofenac salts in water and ethanol/water mixtures by conductivity at 25 degrees C.
Journal of pharmaceutical sciences 1993;82(12):1245-9.
1993: Kitahara M; Ishiguro F; Takayama K; Isowa K; Nagai T
Evaluation of skin damage of cyclic monoterpenes, percutaneous absorption enhancers, by using culture human skin cells.
Biological & pharmaceutical bulletin 1993;16(9):912-6.
1993: Maitani Y; Coutel-Egros A; Obata Y; Nagai T
Prediction of skin permeabilities of diclofenac and propranolol from theoretical partition coefficients determined from cohesion parameters.
Journal of pharmaceutical sciences 1993;82(4):416-20.
1993: Obata Y; Takayama K; Maitani Y; Machida Y; Nagai T
Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat.
Biological & pharmaceutical bulletin 1993;16(3):312-4.
1993: Song Y; Onishi H; Nagai T
Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate.
Biological & pharmaceutical bulletin 1993;16(1):48-54.
1993: Morishita M; Morishita I; Takayama K; Machida Y; Nagai T
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin.
Biological & pharmaceutical bulletin 1993;16(1):68-72.
1993: Ichikawa H; Onishi H; Takahata T; Machida Y; Nagai T
Evaluation of the conjugate between N4-(4-carboxybutyryl)-1-beta-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-beta-D-arabinofuranosylcytosine.
Drug design and discovery 1993;10(4):343-53.
1992: Kikuchi K; Takayama K; Nagai T
Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin.
Chemical & pharmaceutical bulletin 1992;40(11):3108-9.
1992: Song Y; Onishi H; Nagai T
Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin.
Chemical & pharmaceutical bulletin 1992;40(10):2822-5.
1992: Maitani Y; Asano S; Takahashi S; Nakagaki M; Nagai T
Permeability of insulin entrapped in liposome through the nasal mucosa of rabbits.
Chemical & pharmaceutical bulletin 1992;40(6):1569-72.
1992: Príborský J; Takayama K; Príborská Z; Mühlbachová E; Nagai T
The influence of detergents on skin barrier properties.
Pharmacology & toxicology 1992;70(5 Pt 1):344-6.
1992: Hirata M; Takayama K; Nagai T
Formulation optimization of sustained-release tablet of chlorpheniramine maleate by means of extreme vertices design and simultaneous optimization technique.
Chemical & pharmaceutical bulletin 1992;40(3):741-6.
1992: Priborský J; Takayama K; Obata Y; Príborská Z; Nagai T
Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.
Arzneimittel-Forschung 1992;42(2):116-9.
1991: Obata Y; Takayama K; Machida Y; Nagai T
Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
Drug design and discovery 1991;8(2):137-44.
1991: Imasaka K; Yoshida M; Fukuzaki H; Asano M; Kumakura M; Mashimo T; Yamanaka H; Nagai T
Evaluation of new pasty-type implantable devices consisting of poly(epsilon-caprolactone/delta-valerolactone) and Estracyt or estramustine.
Chemical & pharmaceutical bulletin 1991;39(8):2096-9.
1991: Onishi H; Seno Y; Pithayanukul P; Nagai T
Conjugate of N4-(4-carboxybutyryl)-ara-C and ethylenediamine-introduced dextran. Drug release profiles and further in vivo study of its antitumor effects.
Drug design and delivery 1991;7(2):139-45.
1990: Umemura M; Ueda H; Tomono K; Nagai T
Effect of diethyl-beta-cyclodextrin on the release of nitroglycerin from formulations.
Drug design and delivery 1990;6(4):297-310.
1990: Obata Y; Takayama K; Okabe H; Nagai T
Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium).
Drug design and delivery 1990;6(4):319-28.
1990: Onishi H; Pithayanukul P; Nagai T
Antitumor characteristics of the conjugate of N4-(4-carboxybutyryl)-ara-C with ethylenediamine-introduced dextran and its resistance to cytidine deaminase.
Drug design and delivery 1990;6(4):273-80.
1990: Okabe H; Obata Y; Takayama K; Nagai T
Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes.
Drug design and delivery 1990;6(3):229-38.
1990: Takayama K; Hirata M; Machida Y; Masada T; Sannan T; Nagai T
Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.
Chemical & pharmaceutical bulletin 1990;38(7):1993-7.
1990: Quan D Y; Higuchi R I; Takayama K; Higashiyama K; Nagai T
Enhancing effect of piperidone derivatives on the percutaneous absorption of indomethacin.
Drug design and delivery 1990;6(1):61-71.
1990: Igawa T; Maitani Y; Machida Y; Nagai T
Intranasal administration of human fibroblast interferon in mice, rats, rabbits and dogs.
Chemical & pharmaceutical bulletin 1990;38(2):549-51.
1989: Imasaka K; Ueda H; Azuma T; Nagai T
Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur).
Drug design and delivery 1989;5(2):159-65.
1989: Quan D; Higuchi R I; Takayama K; Higashiyama K; Nagai T
Promoting effect of 2-n-alkylcyclohexanones on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;5(2):149-57.
1989: Danyi Q; Takayama K; Nagai T
Effect of cyclohexanone derivatives on in vitro percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):323-30.
1989: Okabe H; Takayama K; Ogura A; Nagai T
Effect of limonene and related compounds on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):313-21.
1989: Imasaka K; Ueda H; Azuma T; Kawaguchi T; Nagai T
Application of new silicone gel to sustained release dosage form of antitumor drug.
Drug design and delivery 1989;4(3):237-46.
1989: Machida Y; Inouye K; Tokumura T; Iwata M; Nagai T
Preparation and evaluation of intragastric buoyant preparations.
Drug design and delivery 1989;4(2):155-61.
1989: Maitani Y; Igawa T; Machida Y; Nagai T
Plasma levels following intranasal and intravenous administration of human interferon-beta to rabbits.
Drug design and delivery 1989;4(2):109-19.
1989: Igawa T; Maitani Y; Machida Y; Nagai T
Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits.
Chemical & pharmaceutical bulletin 1989;37(2):418-21.
1989: Inouye K; Machida Y; Sannan T; Nagai T
Buoyant sustained release granules based on chitosan.
Drug design and delivery 1989;4(1):55-67.
1989: Ueda H; Perrin J H; Nagai T
A microcalorimetric investigation of the binding of cinnarizine to cyclodextrins.
Journal of pharmaceutical and biomedical analysis 1989;7(5):639-42.
1988: Príborský J; Takayama M; Elis J; Nagai T
[The effect of pharmaceutic adjuvants on the transdermal absorption of insulin in vitro]
Casopís lékar?u c?eských 1988;127(52):1617-20.
1988: Príborský J; Takayama K; Nagai T; Waitzová D; Elis J; Makino Y; Suzuki Y
Comparison of penetration-enhancing ability of laurocapram, N-methyl-2-pyrrolidone and dodecyl-L-pyroglutamate.
Pharmaceutisch weekblad. Scientific edition 1988;10(5):189-92.
1988: Igawa T; Maitani Y; Machida Y; Nagai T
Enzyme immunoassay of human fibroblast interferon after intranasal administration with several excipients in rabbits.
Chemical & pharmaceutical bulletin 1988;36(8):3055-9.
1988: Akasaka Y; Ueda H; Takayama K; Machida Y; Nagai T
Preparation and evaluation of bovine serum albumin nanospheres coated with monoclonal antibodies.
Drug design and delivery 1988;3(1):85-97.
1988: Akitoshi Y; Takayama K; Machida Y; Nagai T
Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.
Drug design and delivery 1988;2(3):239-45.
1988: Inouye K; Machida Y; Sannan T; Nagai T
Buoyant sustained release tablets based on chitosan.
Drug design and delivery 1988;2(3):165-75.
1987: Nakagawa Y; Takayama K; Ueda H; Machida Y; Nagai T
Preparation of bovine serum albumin nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):99-107.
1987: Príborský J; Takayama K; Nagai T; Waitzová D; Elis J
Evaluation of in vitro and in situ transdermal absorption of drugs in pig and rat skin.
Chemical & pharmaceutical bulletin 1987;35(12):4915-20.
1987: Príborský J; Takayama K; Nagai T; Waitzová D; Elis J
Combination effect of penetration enhancers and propylene glycol on in vitro transdermal absorption of insulin.
Drug design and delivery 1987;2(2):91-7.
1987: Arai K; Takayama K; Nambu Y; Nambu N; Ueda H; Machida Y; Nagai T
Preparation of polylactic acid-polylipoic acid nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):109-20.
1987: Szeman J; Ueda H; Szejtli J; Fenyvesi E; Watanabe Y; Machida Y; Nagai T
Enhanced percutaneous absorption of homogenized tolnaftate/beta-cyclodextrin polymer ground mixture.
Drug design and delivery 1987;1(4):325-32.
1987: Inouye K; Machida Y; Nagai T
Sustained release tablets based on chitosan and carboxymethylcellulose sodium.
Drug design and delivery 1987;1(4):297-305.
1987: Ishikura T; Nagai T; Sakai Y; Shishikura T; Ebisawa H; Machida Y
Enhanced percutaneous absorption of ionizable water-soluble drugs.
Drug design and delivery 1987;1(4):285-95.
1987: Sekine T; Machida Y; Nagai T
Gel ointment of verapamil for percutaneous absorption.
Drug design and delivery 1987;1(3):245-52.
1987: Machida Y; Tokumura T; Nagai T
Per-oral controlled release dosage form of theophylline using soybean protein.
Drug design and delivery 1987;1(3):187-92.
1987: Machida Y; Tokumura T; Nagai T
Use of soybean protein for controlled release of drugs administered orally.
Drug design and delivery 1987;1(3):179-86.
1987: Iwata M; Machida Y; Nagai T; Masuda H
Double-layered stick-type formulation of bleomycin for treatment of uterine cervical cancer.
Drug design and delivery 1987;1(3):253-60.
1987: Szeman J; Ueda H; Szejtli J; Fenyvesi E; Machida Y; Nagai T
Complexation of several drugs with water-soluble cyclodextrin polymer.
Chemical & pharmaceutical bulletin 1987;35(1):282-8.
1986: Ishikura T; Nagai T; Sakai Y; Shishikura T; Ebisawa H; Machida Y
Comparison of the metabolism of diltiazem following percutaneous, subcutaneous, oral and intravenous administration.
Drug design and delivery 1986;1(2):151-6.
1986: Machida Y; Nagai T; Abe M; Sannan T
Use of chitosan and hydroxypropylchitosan in drug formulations to effect sustained release.
Drug design and delivery 1986;1(2):119-30.
1986: Maitani Y; Igawa T; Machida Y; Nagai T
Intranasal administration of beta-interferon in rabbits.
Drug design and delivery 1986;1(1):65-70.
1984: Fenyvesi E; Takayama K; Szejtli J; Nagai T
Evaluation of cyclodextrin polymer as an additive for furosemide tablet.
Chemical & pharmaceutical bulletin 1984;32(2):670-7.
1984: Fenyvesi E; Shirakura O; Szejtli J; Nagai T
Properties of cyclodextrin polymer as a tabletting aid.
Chemical & pharmaceutical bulletin 1984;32(2):665-9.

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