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Tsuneji Nagai

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Shinji Hidaka; Tadakazu Tokumura; Kazuo Tomono; Toyofumi Suzuki; Haruhisa Ueda; Tsuneji Nagai; Masashi Nagaoka; Rieko Nakane; Yoshiharu Machida
Effect of beta-cyclodextrin on the degradation rate of amoxicillin in acidic solution.
Yuan Li; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.
Hui Li Ma; Yu Feng Xu; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.

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2010: Shinji Hidaka; Tadakazu Tokumura; Kazuo Tomono; Toyofumi Suzuki; Haruhisa Ueda; Tsuneji Nagai; Masashi Nagaoka; Rieko Nakane; Yoshiharu Machida
Effect of beta-cyclodextrin on the degradation rate of amoxicillin in acidic solution.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(6):889-93.
2009: Yuan Li; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.
Nanotechnology 2009;20(5):055106.
2008: Hui Li Ma; Yu Feng Xu; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.
International journal of pharmaceutics 2008;354(1-2):217-26.
2008: Hui-Li Ma; Xian-rong Qi; Wu-Xiao Ding; Yoshie Maitani; Tsuneji Nagai
Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles.
Journal of biomedical materials research. Part A 2008;84(3):598-606.
2007: Hui-li Ma; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate.
International journal of pharmaceutics 2007;333(1-2):177-86.
2007: Yuan Zhang; Xian Rong Qi; Yan Gao; Lai Wei; Yoshie Maitani; Tsuneji Nagai
Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(2):281-90.
2006: Li Feng; Xian-rong Qi; Xing Jun Zhou; Yoshie Maitani; Shi Cong Wang; Yang Jiang; Tsuneji Nagai
Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):35-42.
2006: Tsuneji Nagai
Future DDS by qualified science of science for hybrid, hi-quality and husbandry.
Journal of drug targeting 2006;14(7):446-7.
2005: Jing Shi; Wen-Wei Yan; Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide.
Drug delivery 2005;12(6):349-56.
2005: Xiao-Bing Xiong; Yue Huang; Wan-Liang Lu; Xuan Zhang; Hua Zhang; Tsuneji Nagai; Qiang Zhang
Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):262-75.
2005: Wu-Xiao Ding; Xian-rong Qi; Ping Li; Yoshie Maitani; Tsuneji Nagai
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
International journal of pharmaceutics 2005;300(1-2):38-47.
2005: Kent G Lau; Yoshiyuki Hattori; Sunil Chopra; Edel A O'Toole; Alan Storey; Tsuneji Nagai; Yoshie Maitani
Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.
International journal of pharmaceutics 2005;300(1-2):4-12.
2005: Xiao-Bing Xiong; Yue Huang; Wan-Liang Lu; Xuan Zhang; Hua Zhang; Tsuneji Nagai; Qiang Zhang
Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: in vitro and in vivo.
Journal of pharmaceutical sciences 2005;94(8):1782-93.
2005: Ying Xie; Liya Ye; Xiaobin Zhang; Wei Cui; Jinning Lou; Tsuneji Nagai; Xinpu Hou
Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studies.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(1-2):106-19.
2004: Jundong Dai; Tsuneji Nagai; Xueqing Wang; Tao Zhang; Meng Meng; Qiang Zhang
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A.
International journal of pharmaceutics 2004;280(1-2):229-40.
2004: Xue-Qing Wang; Jun-dong Dai; Zhen Chen; Tao Zhang; Gui-min Xia; Tsuneji Nagai; Qiang Zhang
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(3):421-9.
2004: Chaoju Xiao; Xianrong Qi; Yoshie Maitani; Tsuneji Nagai
Sustained release of cisplatin from multivesicular liposomes: potentiation of antitumor efficacy against S180 murine carcinoma.
Journal of pharmaceutical sciences 2004;93(7):1718-24.
2004: Kozo Takayama; Yasuko Obata; Mariko Morishita; Tsuneji Nagai
Multivariate spline interpolation as a novel method to optimize pharmaceutical formulations.
Die Pharmazie 2004;59(5):392-5.
2004: Mariko Morishita; Yoshinobu Aoki; Masahiro Sakagami; Tsuneji Nagai; Kozo Takayama
In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers.
Pharmaceutical research 2004;21(2):309-16.
2004: Masataka Shiraki; Masayuki Fukuchi; Takeshi Kiriyama; Sumiaki Okamoto; Takehisa Ueno; Hiroshi Sakamoto; Tsuneji Nagai
Alfacalcidol reduces accelerated bone turnover in elderly women with osteoporosis.
Journal of bone and mineral metabolism 2004;22(4):352-9.
2003: Yasunori Miyazaki; Kanako Ogihara; Shigeru Yakou; Tsuneji Nagai; Kozo Takayama
Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.
Biological & pharmaceutical bulletin 2003;26(12):1744-7.
2003: Esti Hendradi; Yasuko Obata; Koichi Isowa; Tsuneji Nagai; Kozo Takayama
Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac.
Biological & pharmaceutical bulletin 2003;26(12):1739-43.
2003: Yasunori Miyazaki; Shigeru Yakou; Tsuneji Nagai; Kozo Takayama
The effect of polyion complex formation on in vitro/in vivo correlation of hydrophilic matrix tablets.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(3):315-26.
2003: Yasunori Miyazaki; Shigeru Yakou; Tsuneji Nagai; Kozo Takayama
Release profiles of theophylline from microspheres consisting of dextran derivatives and cellulose acetate butyrate: effect of polyion complex formation.
Drug development and industrial pharmacy 2003;29(7):795-804.
2003: Ken Katayama; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Double liposomes: hypoglycemic effects of liposomal insulin on normal rats.
Drug development and industrial pharmacy 2003;29(7):725-31.
2003: Silvia Surini; Hidero Akiyama; Mariko Morishita; Tsuneji Nagai; Kozo Takayama
Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate.
Journal of controlled release : official journal of the Controlled Release Society 2003;90(3):291-301.
2003: Chao Jie Li; Yasuko Obata; Kimio Higashiyama; Tsuneji Nagai; Kozo Takayama
Effect of 1-O-ethyl-3-butylcyclohexanol on the skin permeation of drugs with different physicochemical characteristics.
International journal of pharmaceutics 2003;259(1-2):193-8.
2003: Yasunori Miyazaki; Kanako Ogihara; Shigeru Yakou; Tsuneji Nagai; Kozo Takayama
In vitro and in vivo evaluation of mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.
International journal of pharmaceutics 2003;258(1-2):21-9.
2003: Tomoaki Yoshino; Yoshiharu Machida; Hiraku Onishi; Tsuneji Nagai
Preparation and characterization of chitosan microspheres containing doxifluridine.
Drug development and industrial pharmacy 2003;29(4):417-27.
2003: Tsuneji Nagai
[Pharmacy, pharmacists and society--pharmaceutical science and practice with philosophy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2003;123(3):143-50.
2003: Kumi Kawano; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Preparation and pharmacokinetics of pirarubicin loaded dehydration-rehydration vesicles.
International journal of pharmaceutics 2003;252(1-2):73-9.
2003: Koji Nakamura; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats.
Journal of pharmaceutical sciences 2003;92(2):311-8.
2003: Wang Junping; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol.
International journal of pharmaceutics 2003;251(1-2):13-21.
2002: Osamu Ishikawa; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Enhancement of transdermal absorption by switching iontophoresis.
International journal of pharmaceutics 2002;249(1-2):81-8.
2002: Ken Katayama; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Preparation of novel double liposomes using the glass-filter method.
International journal of pharmaceutics 2002;248(1-2):93-9.
2002: Kazunori Asai; Mariko Morishita; Hideo Katsuta; Shoji Hosoda; Katsuhiko Shinomiya; Masahiro Noro; Tsuneji Nagai; Kozo Takayama
The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa.
International journal of pharmaceutics 2002;246(1-2):25-35.
2002: Kumi Kawano; Kouji Nakamura; Kyoko Hayashi; Tsuneji Nagai; Kozo Takayama; Yoshie Maitani
Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells.
Biological & pharmaceutical bulletin 2002;25(6):766-70.
2002: Mariko Morishita; Anthony Lowman; Kozo Takayama; Tsuneji Nagai; Nicholas A Peppas
Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):25-32.
2002: Keiko Tsutsumi; Yasuko Obata; Tsuneji Nagai; Thorsteinn Loftsson; Kozo Takayama
Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs.
International journal of pharmaceutics 2002;238(1-2):161-70.
2001: Chao Jie Li; Kimio Higashiyama; Yoshihiro Yoshimura; Tsuneji Nagai; Kozo Takayama; Yasuko Obata
Promoting mechanism of menthol derivative, 1-O-ethyl-3-buthylcyclohexanol, on the percutaneous absorption of ketoprofen.
Biological & pharmaceutical bulletin 2001;24(9):1044-8.
2001: Yoshie Maitani; Kumi Kawano; K Yamada; Tsuneji Nagai; Kozo Takayama
Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):381-9.
2001: Qiang Zhang; Z Shen; Tsuneji Nagai
Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats.
International journal of pharmaceutics 2001;218(1-2):75-80.
2001: Mariko Morishita; JM Barichello; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin.
International journal of pharmaceutics 2001;212(2):289-93.
2001: Yasuko Obata; Chao Jie Li; Mikito Fujikawa; Kozo Takayama; H Sato; Kimio Higashiyama; Koichi Isowa; Tsuneji Nagai
Evaluation and structure-activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network.
International journal of pharmaceutics 2001;212(2):223-31.
2000: Xian-rong Qi; Yoshie Maitani; Xin-pu Hou; Qiang Zhang; Shu-li Wei; Tsuneji Nagai
[Interactions of insulin with dipalmitoylphosphatidylcholine liposomes].
Yao xue xue bao = Acta pharmaceutica Sinica 2000;35(12):924-8.
2000: M Kajita; Mariko Morishita; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid.
Journal of pharmaceutical sciences 2000;89(10):1243-52.
2000: W Junping; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome.
International journal of pharmaceutics 2000;203(1-2):61-9.
2000: Kozo Takayama; A Morva; Mikito Fujikawa; Yoshiyuki Hattori; Yasuko Obata; Tsuneji Nagai
Formula optimization of theophylline controlled-release tablet based on artificial neural networks.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(2):175-86.
2000: J P Wang; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Pharmacokinetics and antitumor effect of doxorubicin carried by stealth and remote loading proliposome.
Pharmaceutical research 2000;17(7):782-7.
2000: Hiroaki Iwase; Jun-Ichi Sudo; J Terui; Katsuhiko Kakuno; T Watanabe; Kozo Takayama; Tsuneji Nagai
Transdermal absorption of L-dopa from a new system composed of two separate layers of L-dopa and hydrogel in rats.
Drug development and industrial pharmacy 2000;26(7):755-9.
2000: Mariko Morishita; M Kajita; A Suzuki; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA.
International journal of pharmaceutics 2000;201(2):175-85.
2000: K Muramatsu; T Masumizu; Yoshie Maitani; SH Hwang; M Kohno; Kozo Takayama; Tsuneji Nagai
Electron spin resonance studies of dipalmitoylphosphatidylcholine liposomes containing soybean-derived sterylglucoside.
Chemical & pharmaceutical bulletin 2000;48(5):610-3.
2000: Yoshie Maitani; Kouji Nakamura; Hiroshi Suenaga; Katsuo Kamata; Kozo Takayama; Tsuneji Nagai
The enhancing effect of soybean-derived sterylglucoside and beta-sitosterol beta-D-glucoside on nasal absorption in rabbits.
International journal of pharmaceutics 2000;200(1):17-26.
2000: Yasuko Obata; H Sato; Chao Jie Li; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai; Koichi Isowa
Effect of synthesized cyclohexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen.
International journal of pharmaceutics 2000;198(2):191-200.
2000: Yoshinori Onuki; Mariko Morishita; Kozo Takayama; Shinji Tokiwa; Yoshiyuki Chiba; Koichi Isowa; Tsuneji Nagai
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
International journal of pharmaceutics 2000;198(2):147-56.
2000: Yasuko Obata; T Sesumi; Kozo Takayama; Koichi Isowa; S Grosh; S Wick; R Sitz; Tsuneji Nagai
Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis.
Journal of pharmaceutical sciences 2000;89(4):556-61.
2000: SH Hwang; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
High entrapment of insulin and bovine serum albumin into neutral and positively-charged liposomes by the remote loading method.
Chemical & pharmaceutical bulletin 2000;48(3):325-9.
1999: Kozo Takayama; J Takahara; Mikito Fujikawa; H Ichikawa; Tsuneji Nagai
Formula optimization based on artificial neural networks in transdermal drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):161-70.
1999: K Muramatsu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits.
Drug development and industrial pharmacy 1999;25(10):1099-105.
1999: Kouji Nakamura; Yoshie Maitani; Anthony Lowman; Kozo Takayama; Nicholas A Peppas; Tsuneji Nagai
Uptake and release of budesonide from mucoadhesive, pH-sensitive copolymers and their application to nasal delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(3):329-35.
1999: Yoshie Maitani; H Moriya; N Shimoda; Kozo Takayama; Tsuneji Nagai
Distribution characteristics of entrapped recombinant human erythropoietin in liposomes and its intestinal absorption in rats.
International journal of pharmaceutics 1999;185(1):13-22.
1999: Haruhisa Ueda; A Wakamiya; Tomohiro Endo; Hiromasa Nagase; K Tomono; Tsuneji Nagai
Interaction of cyclomaltononaose (delta-CD) with several drugs.
Drug development and industrial pharmacy 1999;25(8):951-4.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Tsuneji Nagai
Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats.
International journal of pharmaceutics 1999;184(2):189-98.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids.
International journal of pharmaceutics 1999;183(2):125-32.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Tsuneji Nagai
Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method.
Drug development and industrial pharmacy 1999;25(4):471-6.
1999: SH Hwang; Yoshie Maitani; Xian-rong Qi; Kozo Takayama; Tsuneji Nagai
Remote loading of diclofenac, insulin and fluorescein isothiocyanate labeled insulin into liposomes by pH and acetate gradient methods.
International journal of pharmaceutics 1999;179(1):85-95.
1999: Keiko Tsutsumi; Yasuko Obata; Kozo Takayama; Koichi Isowa; Tsuneji Nagai
Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch.
International journal of pharmaceutics 1999;177(1):7-14.
1999: Y Takanashi; Kimio Higashiyama; H Komiya; Kozo Takayama; Tsuneji Nagai
Thiomenthol derivatives as novel percutaneous absorption enhancers.
Drug development and industrial pharmacy 1999;25(1):89-94.
1999: Kozo Takayama; Mikito Fujikawa; Tsuneji Nagai
Artificial neural network as a novel method to optimize pharmaceutical formulations.
Pharmaceutical research 1999;16(1):1-6.
1998: Jun-Ichi Sudo; Hiroaki Iwase; J Terui; Katsuhiko Kakuno; M Soyama; Kozo Takayama; Tsuneji Nagai
Transdermal absorption of L-dopa from hydrogel in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;7(1):67-71.
1998: A Suzuki; Mariko Morishita; M Kajita; Kozo Takayama; Koichi Isowa; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid.
Journal of pharmaceutical sciences 1998;87(10):1196-202.
1998: Haruhisa Ueda; D Ou; Tomohiro Endo; Hiromasa Nagase; K Tomono; Tsuneji Nagai
Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs.
Drug development and industrial pharmacy 1998;24(9):863-7.
1998: Keiko Tsutsumi; Yasuko Obata; Kozo Takayama; Thorsteinn Loftsson; Tsuneji Nagai
Effect of cod-liver oil extract on the buccal permeation of ergotamine tartrate.
Drug development and industrial pharmacy 1998;24(8):757-62.
1998: T Yamamoto; Yoshie Maitani; T Ando; Koichi Isowa; Kozo Takayama; Tsuneji Nagai
High absorbency and subchronic morphologic effects on the nasal epithelium of a nasal insulin powder dosage form with a soybean-derived sterylglucoside mixture in rabbits.
Biological & pharmaceutical bulletin 1998;21(8):866-70.
1998: T Ando; Yoshie Maitani; T Yamamoto; Kozo Takayama; Tsuneji Nagai
Nasal insulin delivery in rabbits using soybean-derived sterylglucoside and sterol mixtures as novel enhancers in suspension dosage forms.
Biological & pharmaceutical bulletin 1998;21(8):862-5.
1998: Kazuyuki Shimizu; Yoshie Maitani; Noriko Takahashi; Kozo Takayama; Tsuneji Nagai
Association of liposomes containing a soybean-derived sterylglucoside mixture with rat primary cultured hepatocytes.
Biological & pharmaceutical bulletin 1998;21(8):818-22.
1998: Kazuyuki Shimizu; Xian-rong Qi; Yoshie Maitani; M Yoshii; Kumi Kawano; Kozo Takayama; Tsuneji Nagai
Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mouse models.
Biological & pharmaceutical bulletin 1998;21(7):741-6.
1998: S Yamane; Kozo Takayama; Tsuneji Nagai
Effect of fractal dimension on drug permeation through porous ethylcellulose films.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):103-9.
1997: H Moriya; Yoshie Maitani; N Shimoda; Kozo Takayama; Tsuneji Nagai
Pharmacokinetic and pharmacological profiles of free and liposomal recombinant human erythropoietin after intravenous and subcutaneous administrations in rats.
Pharmaceutical research 1997;14(11):1621-8.
1997: Tsuneji Nagai
[New drug development by innovative drug administration--"change" in pharmaceutical field].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(10-11):963-71.
1997: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Formulation of liposomes with a soybean-derived sterylglucoside mixture and cholesterol for liver targeting.
Biological & pharmaceutical bulletin 1997;20(8):881-6.
1996: M Sato; Hiraku Onishi; J Takahara; Yoshiharu Machida; Tsuneji Nagai
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(9):1170-7.
1996: K Muramatsu; Yoshie Maitani; Tsuneji Nagai
Dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols and cholesterol as a carrier for the oral administration of insulin in rats.
Biological & pharmaceutical bulletin 1996;19(8):1055-8.
1996: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Characterization of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture by differential scanning calorimetry, Fourier transform infrared spectroscopy, and enzymatic assay.
Journal of pharmaceutical sciences 1996;85(7):741-4.
1996: Yoshie Maitani; M Hazama; Y Tojo; N Shimoda; Tsuneji Nagai
Oral administration of recombinant human erythropoietin in liposomes in rats: influence of lipid composition and size of liposomes on bioavailability.
Journal of pharmaceutical sciences 1996;85(4):440-5.
1996: Yoshie Maitani; K Shimada; Tsuneji Nagai
l-Menthol, oleic acid and lauricidin in absorption enhancement of free and sodium salt of diclofenac using ethanol treated silicone membrane as model for skin.
Chemical & pharmaceutical bulletin 1996;44(2):403-8.
1996: M Sato; Hiraku Onishi; M Kitano; Yoshiharu Machida; Tsuneji Nagai
Preparation and drug release characteristics of the conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(2):241-5.
1996: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Evaluation of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture for liver targeting.
Journal of drug targeting 1996;4(4):245-53.
1995: A Matsuzawa; M Morishita; Kozo Takayama; Tsuneji Nagai
Absorption of insulin using water-in-oil-in-water emulsion from an enteral loop in rats.
Biological & pharmaceutical bulletin 1995;18(12):1718-23.
1995: Yoshie Maitani; M Hazama; H Tojo; Xian-rong Qi; Tsuneji Nagai
Effects of orally administered liposomes with soybean-derived sterols and their glucosides on rat body weight.
Biological & pharmaceutical bulletin 1995;18(11):1551-5.
1995: T Yamamoto; Yoshie Maitani; Koichi Isowa; Tsuneji Nagai
Morphologic examination of rabbit nasal mucosa after the nasal administration of insulin peanut oil suspension and a powder dosage form with soybean-derived sterylglucoside.
Biological & pharmaceutical bulletin 1995;18(6):887-90.
1995: N Shimoda; Yoshie Maitani; Y Machida; Tsuneji Nagai
Effects of dose, pH and osmolarity on intranasal absorption of recombinant human erythropoietin in rats.
Biological & pharmaceutical bulletin 1995;18(5):734-9.
1995: N Ohara; Kozo Takayama; Tsuneji Nagai
Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs.
Biological & pharmaceutical bulletin 1995;18(3):439-42.
1995: Xian-rong Qi; Yoshie Maitani; N Shimoda; K Sakaguchi; Tsuneji Nagai
Evaluation of liposomal erythropoietin prepared with reverse-phase evaporation vesicle method by subcutaneous administration in rats.
Chemical & pharmaceutical bulletin 1995;43(2):295-9.
1995: Xian-rong Qi; Yoshie Maitani; Tsuneji Nagai
Rates of systemic degradation and reticuloendothelial system uptake of calcein in the dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols in mice.
Pharmaceutical research 1995;12(1):49-52.
1994: K K Levison; Kozo Takayama; Koichi Isowa; K Okabe; Tsuneji Nagai
Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers.
Journal of pharmaceutical sciences 1994;83(9):1367-72.
1993: Yoshie Maitani; M Kugo; M Nakagaki; Tsuneji Nagai
Ionic size and behavior of diclofenac salts in water and ethanol/water mixtures by conductivity at 25 degrees C.
Journal of pharmaceutical sciences 1993;82(12):1245-9.
1993: M Kitahara; F Ishiguro; Kozo Takayama; Koichi Isowa; Tsuneji Nagai
Evaluation of skin damage of cyclic monoterpenes, percutaneous absorption enhancers, by using culture human skin cells.
Biological & pharmaceutical bulletin 1993;16(9):912-6.
1993: Yoshie Maitani; A Coutel-Egros; Y Obata; Tsuneji Nagai
Prediction of skin permeabilities of diclofenac and propranolol from theoretical partition coefficients determined from cohesion parameters.
Journal of pharmaceutical sciences 1993;82(4):416-20.
1993: Y Obata; Kozo Takayama; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat.
Biological & pharmaceutical bulletin 1993;16(3):312-4.
1993: Y Song; Hiraku Onishi; Tsuneji Nagai
Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate.
Biological & pharmaceutical bulletin 1993;16(1):48-54.
1993: H Ichikawa; Hiraku Onishi; T Takahata; Yoshiharu Machida; Tsuneji Nagai
Evaluation of the conjugate between N4-(4-carboxybutyryl)-1-beta-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-beta-D-arabinofuranosylcytosine.
Drug design and discovery 1993;10(4):343-53.
1993: M Morishita; I Morishita; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin.
Biological & pharmaceutical bulletin 1993;16(1):68-72.
1992: K Kikuchi; Kozo Takayama; Tsuneji Nagai
Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin.
Chemical & pharmaceutical bulletin 1992;40(11):3108-9.
1992: Y Song; Hiraku Onishi; Tsuneji Nagai
Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin.
Chemical & pharmaceutical bulletin 1992;40(10):2822-5.
1992: Yoshie Maitani; S Asano; S Takahashi; M Nakagaki; Tsuneji Nagai
Permeability of insulin entrapped in liposome through the nasal mucosa of rabbits.
Chemical & pharmaceutical bulletin 1992;40(6):1569-72.
1992: J Príborský; Kozo Takayama; Z Príborská; E Mühlbachová; Tsuneji Nagai
The influence of detergents on skin barrier properties.
Pharmacology & toxicology 1992;70(5 Pt 1):344-6.
1992: M Hirata; Kozo Takayama; Tsuneji Nagai
Formulation optimization of sustained-release tablet of chlorpheniramine maleate by means of extreme vertices design and simultaneous optimization technique.
Chemical & pharmaceutical bulletin 1992;40(3):741-6.
1992: J Priborský; Kozo Takayama; Y Obata; Z Príborská; Tsuneji Nagai
Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.
Arzneimittel-Forschung 1992;42(2):116-9.
1991: Y Obata; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
Drug design and discovery 1991;8(2):137-44.
1991: K Imasaka; M Yoshida; H Fukuzaki; M Asano; M Kumakura; T Mashimo; H Yamanaka; Tsuneji Nagai
Evaluation of new pasty-type implantable devices consisting of poly(epsilon-caprolactone/delta-valerolactone) and Estracyt or estramustine.
Chemical & pharmaceutical bulletin 1991;39(8):2096-9.
1991: Hiraku Onishi; Y Seno; P Pithayanukul; Tsuneji Nagai
Conjugate of N4-(4-carboxybutyryl)-ara-C and ethylenediamine-introduced dextran. Drug release profiles and further in vivo study of its antitumor effects.
Drug design and delivery 1991;7(2):139-45.
1990: M Umemura; Haruhisa Ueda; K Tomono; Tsuneji Nagai
Effect of diethyl-beta-cyclodextrin on the release of nitroglycerin from formulations.
Drug design and delivery 1990;6(4):297-310.
1990: Y Obata; Kozo Takayama; H Okabe; Tsuneji Nagai
Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium).
Drug design and delivery 1990;6(4):319-28.
1990: Hiraku Onishi; P Pithayanukul; Tsuneji Nagai
Antitumor characteristics of the conjugate of N4-(4-carboxybutyryl)-ara-C with ethylenediamine-introduced dextran and its resistance to cytidine deaminase.
Drug design and delivery 1990;6(4):273-80.
1990: H Okabe; Y Obata; Kozo Takayama; Tsuneji Nagai
Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes.
Drug design and delivery 1990;6(3):229-38.
1990: Kozo Takayama; M Hirata; Yoshiharu Machida; T Masada; T Sannan; Tsuneji Nagai
Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.
Chemical & pharmaceutical bulletin 1990;38(7):1993-7.
1990: D Y Quan; R I Higuchi; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai
Enhancing effect of piperidone derivatives on the percutaneous absorption of indomethacin.
Drug design and delivery 1990;6(1):61-71.
1990: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Intranasal administration of human fibroblast interferon in mice, rats, rabbits and dogs.
Chemical & pharmaceutical bulletin 1990;38(2):549-51.
1989: K Imasaka; Haruhisa Ueda; T Azuma; Tsuneji Nagai
Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur).
Drug design and delivery 1989;5(2):159-65.
1989: D Quan; R I Higuchi; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai
Promoting effect of 2-n-alkylcyclohexanones on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;5(2):149-57.
1989: Q Danyi; Kozo Takayama; Tsuneji Nagai
Effect of cyclohexanone derivatives on in vitro percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):323-30.
1989: H Okabe; Kozo Takayama; A Ogura; Tsuneji Nagai
Effect of limonene and related compounds on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):313-21.
1989: K Imasaka; Haruhisa Ueda; T Azuma; T Kawaguchi; Tsuneji Nagai
Application of new silicone gel to sustained release dosage form of antitumor drug.
Drug design and delivery 1989;4(3):237-46.
1989: Yoshiharu Machida; K Inouye; T Tokumura; M Iwata; Tsuneji Nagai
Preparation and evaluation of intragastric buoyant preparations.
Drug design and delivery 1989;4(2):155-61.
1989: Yoshie Maitani; T Igawa; Yoshiharu Machida; Tsuneji Nagai
Plasma levels following intranasal and intravenous administration of human interferon-beta to rabbits.
Drug design and delivery 1989;4(2):109-19.
1989: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits.
Chemical & pharmaceutical bulletin 1989;37(2):418-21.
1989: K Inouye; Yoshiharu Machida; T Sannan; Tsuneji Nagai
Buoyant sustained release granules based on chitosan.
Drug design and delivery 1989;4(1):55-67.
1989: Haruhisa Ueda; J H Perrin; Tsuneji Nagai
A microcalorimetric investigation of the binding of cinnarizine to cyclodextrins.
Journal of pharmaceutical and biomedical analysis 1989;7(5):639-42.
1988: J Príborský; M Takayama; J Elis; Tsuneji Nagai
[The effect of pharmaceutic adjuvants on the transdermal absorption of insulin in vitro].
Casopís lékar̆ů c̆eských 1988;127(52):1617-20.
1988: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis; Y Makino; Y Suzuki
Comparison of penetration-enhancing ability of laurocapram, N-methyl-2-pyrrolidone and dodecyl-L-pyroglutamate.
Pharmaceutisch weekblad. Scientific edition 1988;10(5):189-92.
1988: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Enzyme immunoassay of human fibroblast interferon after intranasal administration with several excipients in rabbits.
Chemical & pharmaceutical bulletin 1988;36(8):3055-9.
1988: Y Akasaka; Haruhisa Ueda; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Preparation and evaluation of bovine serum albumin nanospheres coated with monoclonal antibodies.
Drug design and delivery 1988;3(1):85-97.
1988: Y Akitoshi; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.
Drug design and delivery 1988;2(3):239-45.
1988: K Inouye; Yoshiharu Machida; T Sannan; Tsuneji Nagai
Buoyant sustained release tablets based on chitosan.
Drug design and delivery 1988;2(3):165-75.
1987: Y Nakagawa; Kozo Takayama; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of bovine serum albumin nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):99-107.
1987: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis
Evaluation of in vitro and in situ transdermal absorption of drugs in pig and rat skin.
Chemical & pharmaceutical bulletin 1987;35(12):4915-20.
1987: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis
Combination effect of penetration enhancers and propylene glycol on in vitro transdermal absorption of insulin.
Drug design and delivery 1987;2(2):91-7.
1987: K Arai; Kozo Takayama; Y Nambu; N Nambu; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of polylactic acid-polylipoic acid nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):109-20.
1987: J Szeman; Haruhisa Ueda; J Szejtli; E Fenyvesi; Y Watanabe; Yoshiharu Machida; Tsuneji Nagai
Enhanced percutaneous absorption of homogenized tolnaftate/beta-cyclodextrin polymer ground mixture.
Drug design and delivery 1987;1(4):325-32.
1987: K Inouye; Yoshiharu Machida; Tsuneji Nagai
Sustained release tablets based on chitosan and carboxymethylcellulose sodium.
Drug design and delivery 1987;1(4):297-305.
1987: T Ishikura; Tsuneji Nagai; Y Sakai; T Shishikura; H Ebisawa; Yoshiharu Machida
Enhanced percutaneous absorption of ionizable water-soluble drugs.
Drug design and delivery 1987;1(4):285-95.
1987: T Sekine; Yoshiharu Machida; Tsuneji Nagai
Gel ointment of verapamil for percutaneous absorption.
Drug design and delivery 1987;1(3):245-52.
1987: Yoshiharu Machida; T Tokumura; Tsuneji Nagai
Per-oral controlled release dosage form of theophylline using soybean protein.
Drug design and delivery 1987;1(3):187-92.
1987: Yoshiharu Machida; T Tokumura; Tsuneji Nagai
Use of soybean protein for controlled release of drugs administered orally.
Drug design and delivery 1987;1(3):179-86.
1987: M Iwata; Yoshiharu Machida; Tsuneji Nagai; H Masuda
Double-layered stick-type formulation of bleomycin for treatment of uterine cervical cancer.
Drug design and delivery 1987;1(3):253-60.
1987: J Szeman; Haruhisa Ueda; J Szejtli; E Fenyvesi; Yoshiharu Machida; Tsuneji Nagai
Complexation of several drugs with water-soluble cyclodextrin polymer.
Chemical & pharmaceutical bulletin 1987;35(1):282-8.
1986: T Ishikura; Tsuneji Nagai; Y Sakai; T Shishikura; H Ebisawa; Yoshiharu Machida
Comparison of the metabolism of diltiazem following percutaneous, subcutaneous, oral and intravenous administration.
Drug design and delivery 1986;1(2):151-6.
1986: Yoshiharu Machida; Tsuneji Nagai; M Abe; T Sannan
Use of chitosan and hydroxypropylchitosan in drug formulations to effect sustained release.
Drug design and delivery 1986;1(2):119-30.
1986: Yoshie Maitani; T Igawa; Yoshiharu Machida; Tsuneji Nagai
Intranasal administration of beta-interferon in rabbits.
Drug design and delivery 1986;1(1):65-70.
1984: E Fenyvesi; K Takayama; J Szejtli; Tsuneji Nagai
Evaluation of cyclodextrin polymer as an additive for furosemide tablet.
Chemical & pharmaceutical bulletin 1984;32(2):670-7.
1984: E Fenyvesi; O Shirakura; J Szejtli; Tsuneji Nagai
Properties of cyclodextrin polymer as a tabletting aid.
Chemical & pharmaceutical bulletin 1984;32(2):665-9.