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Hiroshi Naganawa

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Masayuki Igarashi; Yoshiaki Takahashi; Tetsuo Shitara; Hikaru Nakamura; Hiroshi Naganawa; Toshiaki Miyake; Yuzuru Akamatsu
Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins.
Tetsuya Someno; Setsuko Kunimoto; Hikaru Nakamura; Hiroshi Naganawa; Daishiro Ikeda
Absolute configuration of kigamicins A, C and D.
Tetsuya Someno; Hiroyuki Kumagai; Shun-ichi Ohba; Masahide Amemiya; Hiroshi Naganawa; Masaaki Ishizuka; Daishiro Ikeda
ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. II. Physico-chemical properties and structure elucidation.

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2005: Masayuki Igarashi; Yoshiaki Takahashi; Tetsuo Shitara; Hikaru Nakamura; Hiroshi Naganawa; Toshiaki Miyake; Yuzuru Akamatsu
Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins.
The Journal of antibiotics 2005;58(5):327-37.
2005: Tetsuya Someno; Setsuko Kunimoto; Hikaru Nakamura; Hiroshi Naganawa; Daishiro Ikeda
Absolute configuration of kigamicins A, C and D.
The Journal of antibiotics 2005;58(1):56-60.
2004: Tetsuya Someno; Hiroyuki Kumagai; Shun-ichi Ohba; Masahide Amemiya; Hiroshi Naganawa; Masaaki Ishizuka; Daishiro Ikeda
ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. II. Physico-chemical properties and structure elucidation.
The Journal of antibiotics 2004;57(2):104-9.
2004: Hideki Hashizume; Sehei Hirosawa; Ryuichi Sawa; Yasuhiko Muraoka; Daishiro Ikeda; Hiroshi Naganawa; Masayuki Igarashi
Tripropeptins, novel antimicrobial agents produced by Lysobacter sp.
The Journal of antibiotics 2004;57(1):52-8.
2003: Setsuko Kunimoto; Tetsuya Someno; Yohko Yamazaki; Jie Lu; Hiroyasu Esumi; Hiroshi Naganawa
Kigamicins, novel antitumor antibiotics. II. Structure determination.
The Journal of antibiotics 2003;56(12):1012-7.
2002: Ryuichi Sekizawa; Souichi Ikeno; Hikaru Nakamura; Hiroshi Naganawa; Susumu Matsui; Hironobu Iinuma; Tomio Takeuchi
Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme.
Journal of natural products 2002;65(10):1491-3.
2001: Isao Momose; Ryuichi Sekizawa; Sehei Hirosawa; Daishiro Ikeda; Hiroshi Naganawa; Hironobu Iinuma; Tomio Takeuchi
Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2. II. Structure determination and synthesis.
The Journal of antibiotics 2001;54(12):1004-12.
2001: Ryuichi Sekizawa; Isao Momose; Naoko Kinoshita; Hiroshi Naganawa; M Hamada; Yasuhiko Muraoka; Hironobu Iinuma; Tomio Takeuchi
Isolation and structural determination of phepropeptins A, B, C, and D, new proteasome inhibitors, produced by Streptomyces sp.
The Journal of antibiotics 2001;54(11):874-81.
2001: Tetsuo Akiyama; Masatoshi Abe; Shigeko Harada; Fukiko Kojima; Ryuichi Sawa; Y Takahashi; Hiroshi Naganawa; Y Homma; M Hamada; A Yamaguchi; T Aoyagi; Yasuhiko Muraoka; Tomio Takeuchi
Sulphostin, a potent inhibitor for dipeptidyl peptidase IV from Streptomyces sp. MK251-43F3.
The Journal of antibiotics 2001;54(9):744-6.
2000: M Iijima; Tetsuya Someno; Masahide Amemiya; Masaaki Ishizuka; Hiroshi Naganawa; Tomio Takeuchi
Biosynthesis of IC202C, a new siderophore with immunosuppressive activity.
The Journal of antibiotics 2000;53(12):1411-5.
2000: M Igarashi; Hikaru Nakamura; Hiroshi Naganawa; Tomio Takeuchi
Tubelactomicin A, a novel 16-membered lactone antibiotic, from Nocardia sp. II. Structure elucidation.
The Journal of antibiotics 2000;53(10):1102-7.
2000: N Hosokawa; Hiroshi Naganawa; M Hamada; Hironobu Iinuma; Tomio Takeuchi; KS Tsuchiya; M Hori
New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin.
The Journal of antibiotics 2000;53(9):886-94.
2000: N Hosokawa; Isao Momose; Ryuichi Sekizawa; Hiroshi Naganawa; Hironobu Iinuma; Tomio Takeuchi; Susumu Matsui
New strobilurins O and P from a mushroom.
The Journal of antibiotics 2000;53(3):297-300.
2000: Isao Momose; Ryuichi Sekizawa; N Hosokawa; Hironobu Iinuma; Susumu Matsui; Hikaru Nakamura; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Melleolides K, L and M, new melleolides from Armillariella mellea.
The Journal of antibiotics 2000;53(2):137-43.
1999: M Igarashi; T Shida; Y Sasaki; Naoko Kinoshita; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Vinylamycin, a new depsipeptide antibiotic, from Streptomyces sp.
The Journal of antibiotics 1999;52(10):873-9.
1999: Isao Momose; Sehei Hirosawa; Hikaru Nakamura; Hiroshi Naganawa; Hironobu Iinuma; Daishiro Ikeda; Tomio Takeuchi
Decatromicins A and B, new antibiotics produced by Actinomadura sp. MK73-NF4. II. Structure determination.
The Journal of antibiotics 1999;52(9):787-96.
1999: M Iijima; Tetsuya Someno; Masaaki Ishizuka; R Sawa; Hiroshi Naganawa; Tomio Takeuchi
IC202B and C, new siderophores with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19.
The Journal of antibiotics 1999;52(9):775-80.
1999: N Hosokawa; Hiroshi Naganawa; T Kasahara; S Hattori; M Hamada; Tomio Takeuchi; S Yamamoto; KS Tsuchiya; M Hori
Futalosine and its derivatives, new nucleoside analogs.
Chemical & pharmaceutical bulletin 1999;47(7):1032-4.
1999: N Matsumoto; T Tsuchida; Hikaru Nakamura; Ryuichi Sawa; Y Takahashi; Hiroshi Naganawa; Hironobu Iinuma; T Sawa; Tomio Takeuchi; M Shiro
Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. II. Structure determination.
The Journal of antibiotics 1999;52(3):276-80.
1999: M Iijima; Tetsuya Someno; Masahide Amemiya; R Sawa; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi
IC202A, a new siderophore with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19. II. Physico-chemical properties and structure elucidation.
The Journal of antibiotics 1999;52(1):25-8.
1998: Tetsuo Akiyama; K T Nakamura; Y Takahashi; Hiroshi Naganawa; Yasuhiko Muraoka; T Aoyagi; Tomio Takeuchi
Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391. II. Structure determination.
The Journal of antibiotics 1998;51(6):586-8.
1998: Tetsuo Akiyama; Ryuichi Sawa; Hiroshi Naganawa; Yasuhiko Muraoka; T Aoyagi; Tomio Takeuchi
Epostatin, new inhibitor of dipeptidyl peptidase II, produced by streptomyces sp. MJ995-OF5 II. Structure elucidation.
The Journal of antibiotics 1998;51(3):372-3.
1998: Isao Momose; Naoko Kinoshita; Ryuichi Sawa; Hiroshi Naganawa; Hironobu Iinuma; M Hamada; Tomio Takeuchi
Nothramicin, a new anthracycline antibiotic from Nocardia sp. MJ896-43F17.
The Journal of antibiotics 1998;51(2):130-5.
1998: M Igarashi; T Tsuchida; Naoko Kinoshita; M Kamijima; Ryuichi Sawa; T Sawa; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; K Yamazaki; M Ishizuka
Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp.
The Journal of antibiotics 1998;51(2):123-9.
1998: Isao Momose; W Chen; Hikaru Nakamura; Hiroshi Naganawa; Hironobu Iinuma; Tomio Takeuchi
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination.
The Journal of antibiotics 1998;51(1):26-32.
1997: M Igarashi; Hikaru Nakamura; Hiroshi Naganawa; Tomio Takeuchi
Resormycin, a novel herbicidal and antifungal antibiotic produced by a strain of Streptomyces platensis. II. Structure elucidation of resormycin.
The Journal of antibiotics 1997;50(12):1026-31.
1997: M Igarashi; Hikaru Nakamura; Hiroshi Naganawa; Tomio Takeuchi
Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. II. Structure elucidation of formamicin.
The Journal of antibiotics 1997;50(11):932-6.
1997: N Matsumoto; T Tsuchida; Ryuichi Sawa; Hironobu Iinuma; Hikaru Nakamura; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. III. Physico-chemical properties and structure determination.
The Journal of antibiotics 1997;50(11):912-5.
1997: M Chino; K Nishikawa; Ryuichi Sawa; M Hamada; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2. III. Biosynthesis.
The Journal of antibiotics 1997;50(9):781-4.
1997: S Kondo; Hikaru Nakamura; Y Ikeda; Hiroshi Naganawa; K Maeda; Tomio Takeuchi
Structures of two remarkable dimerization products of sarkomycin.
The Journal of antibiotics 1997;50(4):363-5.
1997: N Kawamura; Hikaru Nakamura; Ryuichi Sawa; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Pyralomicins, novel antibiotics from Microtetraspora spiralis. IV. Absolute configuration.
The Journal of antibiotics 1997;50(2):147-9.
1997: M Chino; K Nishikawa; T Tsuchida; Ryuichi Sawa; Hikaru Nakamura; K T Nakamura; Yasuhiko Muraoka; Daishiro Ikeda; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin.
The Journal of antibiotics 1997;50(2):143-6.
1997: M Nagai; Fukiko Kojima; Hiroshi Naganawa; M Hamada; T Aoyagi; Tomio Takeuchi
Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3.
The Journal of antibiotics 1997;50(1):82-4.
1996: S Murakami; S Harada; Y Takahashi; Hiroshi Naganawa; Tomio Takeuchi; T Aoyagi
Piperastatin B: a new selective serine carboxypeptidase inhibitor from Streptomyces lavendofoliae MJ908-WF13.
Journal of enzyme inhibition 1996;11(1):51-66.
1996: N Kawamura; Naoko Kinoshita; Ryuichi Sawa; Y Takahashi; T Sawa; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Pyralomicins, novel antibiotics from Microtetraspora spiralis. I. Taxonomy and production.
The Journal of antibiotics 1996;49(7):706-9.
1996: N Kawamura; Ryuichi Sawa; Y Takahashi; K Isshiki; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Pyralomicins, novel antibiotics from Microtetraspora spiralis. II. Structure determination.
The Journal of antibiotics 1996;49(7):651-6.
1996: N Kawamura; Ryuichi Sawa; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Pyralomicins, novel antibiotics from Microtetraspora spiralis. III. Biosynthesis of pyralomicin 1a.
The Journal of antibiotics 1996;49(7):657-60.
1996: N Hosokawa; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; Souichi Ikeno; Makoto Hori
Hydroxymycotrienins A and B, new ansamycin group antibiotics.
The Journal of antibiotics 1996;49(5):425-31.
1996: T Tsuchida; M Umekita; Naoko Kinoshita; Hironobu Iinuma; H Nakamura; K Nakamura; Hiroshi Naganawa; T Sawa; M Hamada; Tomio Takeuchi
Epoxyquinomicins A and B, new antibiotics from Amycolatopsis.
The Journal of antibiotics 1996;49(3):326-8.
1996: S Murakami; Y Takahashi; Hiroshi Naganawa; Tomio Takeuchi; T Aoyagi
Piperastatin A, a new selective serine carboxypeptidase inhibitor produced by actinomycete. II. Physico-chemical properties and structure determination.
Journal of enzyme inhibition 1996;10(2):105-14.
1995: M Igarashi; W Chen; T Tsuchida; M Umekita; T Sawa; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
4'-Deacetyl-(-)-griseusins A and B, new naphthoquinone antibiotics from an actinomycete.
The Journal of antibiotics 1995;48(12):1502-5.
1995: T Tsuchida; Ryuichi Sawa; Y Takahashi; Hironobu Iinuma; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Azicemicins A and B, new antimicrobial agents produced by Amycolatopsis. II. Structure determination.
The Journal of antibiotics 1995;48(10):1148-52.
1995: T Tsuchida; Hironobu Iinuma; Ryuichi Sawa; Y Takahashi; Hikaru Nakamura; K T Nakamura; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Tetrodecamycin and dihydrotetrodecamycin, new antimicrobial antibiotics against Pasteurella piscicida produced by Streptomyces nashvillensis MJ885-mF8. II. Structure determination.
The Journal of antibiotics 1995;48(10):1110-4.
1995: N Hosokawa; Hiroshi Naganawa; H Inuma; M Hamada; Tomio Takeuchi; T Kanbe; Makoto Hori
Thiazinotrienomycins, new ansamycin group antibiotics.
The Journal of antibiotics 1995;48(6):471-8.
1995: M Igarashi; C Sasao; A Yoshida; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Ochracenomicins A, B and C, new benz[a]anthraquinone antibiotics from Amicolatopsis sp.
The Journal of antibiotics 1995;48(4):335-7.
1995: S Murakami; Y Takahashi; Hiroshi Naganawa; Tomio Takeuchi; T Aoyagi
Belactins A and B, new serine carboxypeptidase inhibitors produced by Actinomycete. II. Physico-chemical properties, structure determinations and enzymatic inhibitory activities compared with other beta-lactone containing inhibitors.
Journal of enzyme inhibition 1995;9(4):277-84.
1995: T Aoyama; Fukiko Kojima; Chiaki Imada; Yasuhiko Muraoka; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi; T Aoyagi
Pyrostatins A and B, new inhibitors of N-acetyl-beta-D-glucosaminidase, produced by Streptomyces sp. SA-3501.
Journal of enzyme inhibition 1995;8(4):223-32.
1994: Ryuichi Sawa; Y Takahashi; Hikaru Nakamura; K T Nakamura; Hiroshi Naganawa; Tomio Takeuchi
Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. III. Determination of absolute configuration.
The Journal of antibiotics 1994;47(11):1280-3.
1994: Ryuichi Sawa; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. II. Structure elucidation by NMR studies.
The Journal of antibiotics 1994;47(11):1273-9.
1994: Ryuichi Sawa; Y Takahashi; S Itoh; K Shimanaka; Naoko Kinoshita; Y Homma; M Hamada; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1994;47(11):1266-72.
1994: K Shimanaka; Y Takahashi; Hironobu Iinuma; Hiroshi Naganawa; Tomio Takeuchi
Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C.
The Journal of antibiotics 1994;47(10):1153-9.
1994: K Shimanaka; Y Takahashi; Hironobu Iinuma; Hiroshi Naganawa; Tomio Takeuchi
Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D.
The Journal of antibiotics 1994;47(10):1145-52.
1994: M Amemiya; Tetsuya Someno; R Sawa; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination.
The Journal of antibiotics 1994;47(5):541-4.
1993: M Ueno; M Amemiya; Tetsuya Someno; T Masuda; H Iinuma; Hiroshi Naganawa; M Hamada; Masaaki Ishizuka; Tomio Takeuchi
IC101, extracellular matrix antagonist produced by Streptomyces sp. MJ202-72F3. Production, isolation, structure determination and biological activity.
The Journal of antibiotics 1993;46(11):1658-65.
1993: T Aoyama; W Zhao; Fukiko Kojima; Yasuhiko Muraoka; Hiroshi Naganawa; Tomio Takeuchi; T Aoyagi
Cysfluoretin, a new inhibitor of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12.
The Journal of antibiotics 1993;46(9):1471-4.
1993: Y Hosoya; T Kameyama; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi
Anisomycin and new congeners active against human tumor cell lines.
The Journal of antibiotics 1993;46(8):1300-2.
1993: M Ueno; Tetsuya Someno; R Sawa; H Iinuma; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi
Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.
The Journal of antibiotics 1993;46(6):979-84.
1993: M Ueno; Tetsuya Someno; R Sawa; H Iinuma; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi
Delaminomycins, novel extracellular matrix receptor antagonist. III. Physico-chemical properties and structure elucidation of delaminomycins B and C.
The Journal of antibiotics 1993;46(6):1020-3.
1993: T Aoyama; Fukiko Kojima; F Abe; Yasuhiko Muraoka; Hiroshi Naganawa; Tomio Takeuchi; T Aoyagi
Bequinostatins A and B new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
The Journal of antibiotics 1993;46(6):914-20.
1993: T Aoyama; Fukiko Kojima; T Yamazaki; T Tatee; F Abe; Yasuhiko Muraoka; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi
Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
The Journal of antibiotics 1993;46(5):712-8.
1993: N Hosokawa; Hironobu Iinuma; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; T Itoh; Makoto Hori
A new antibiotic, structurally related to leptomycin A, flattens the morphology of v-ras(ts) NRK cells.
The Journal of antibiotics 1993;46(4):676-8.
1993: H Nishioka; T Sawa; Y Takahashi; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; Kazuo Umezawa
Isolation and structure determination of novel phosphatidylinositol turnover inhibitors, piericidin B5 and B5 N-oxide, from Streptomyces sp.
The Journal of antibiotics 1993;46(4):564-8.
1992: Y Ikeda; Hiroshi Naganawa; S Kondo; Tomio Takeuchi
Preparation of 13C and 15N labeled bellenamine and its degradation products.
The Journal of antibiotics 1992;45(12):1925-9.
1992: Y Ikeda; Hiroshi Naganawa; S Kondo; Tomio Takeuchi
Biosynthesis of bellenamine by Streptomyces nashvillensis using stable isotope labeled compounds.
The Journal of antibiotics 1992;45(12):1919-24.
1992: M Ueno; M Iijima; T Masuda; N Kinoshita; H Iinuma; Hiroshi Naganawa; M Hamada; Masaaki Ishizuka; Tomio Takeuchi
Dethymicin, a novel immunosuppressant isolated from an Amycolatopsis. Fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1992;45(12):1819-26.
1992: M Hatsu; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi; Y Kodama
The structure of pyrizinostatin.
The Journal of antibiotics 1992;45(12):1961-2.
1992: T Aoyama; Hiroshi Naganawa; Yasuhiko Muraoka; T Aoyagi; Tomio Takeuchi
Biosynthesis of benastatin A.
The Journal of antibiotics 1992;45(11):1767-72.
1992: T Aoyagi; M Hatsu; Chiaki Imada; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi
Pyrizinostatin: a new inhibitor of pyroglutamyl peptidase.
The Journal of antibiotics 1992;45(11):1795-6.
1992: D Komagata; Ryuichi Sawa; Naoko Kinoshita; Chiaki Imada; T Sawa; Hiroshi Naganawa; M Hamada; Yoshiro Okami; Tomio Takeuchi
Isolation of glutathione-S-transferase inhibitors.
The Journal of antibiotics 1992;45(10):1681-3.
1992: M Iijima; T Masuda; Hikaru Nakamura; Hiroshi Naganawa; S Kurasawa; Yoshiro Okami; M Ishizuka; Tomio Takeuchi; Y Iitake
Metacytofilin, a novel immunomodulator produced by Metarhizium sp. TA2759.
The Journal of antibiotics 1992;45(9):1553-6.
1992: T Aoyama; Hiroshi Naganawa; Yasuhiko Muraoka; Hikaru Nakamura; T Aoyagi; Tomio Takeuchi; Y Iitaka
Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B.
The Journal of antibiotics 1992;45(9):1391-6.
1992: D Komagata; Yasuhiko Muraoka; Ryuichi Sawa; Y Takahashi; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. II. Structure determination.
The Journal of antibiotics 1992;45(7):1122-4.
1992: M Hatsu; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi
Benarthin: a new inhibitor of pyroglutamyl peptidase. II. Physico-chemical properties and structure determination.
The Journal of antibiotics 1992;45(7):1084-7.
1992: Ryuichi Sawa; Y Takahashi; S Itoh; K Shimanaka; N Matsuda; M Hamada; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Aldecalmycin, a new antimicrobial antibiotic from Streptomyces.
The Journal of antibiotics 1992;45(1):136-9.
1991: M Nagai; K Ogawa; Yasuhiko Muraoka; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi
Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. II. Structure determination and inhibitory activities.
The Journal of antibiotics 1991;44(9):956-61.
1991: H Nishioka; T Sawa; H Nakamura; Hironobu Iinuma; Daishiro Ikeda; Ryuichi Sawa; Hiroshi Naganawa; C Hayashi; M Hamada; Tomio Takeuchi
Isolation and structure determination of novel phosphatidylinositol kinase inhibitors, echiguanines A and B, from Streptomyces sp.
Journal of natural products 1991;54(5):1321-5.
1991: S Yoshida; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi; Y Takeuchi; Y Kodama
Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin.
The Journal of antibiotics 1991;44(6):579-81.
1991: Ryuichi Sawa; N Matsuda; T Uchida; T Ikeda; T Sawa; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Dioxamycin, a new benz[a]anthraquinone antibiotic.
The Journal of antibiotics 1991;44(4):396-402.
1991: S Yoshida; T Aoyagi; Shigeko Harada; N Matsuda; T Ikeda; Hiroshi Naganawa; M Hamada; Tomio Takeuchi
Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium.
The Journal of antibiotics 1991;44(1):111-2.
1990: K Shiomi; Hironobu Iinuma; Hiroshi Naganawa; M Hamada; S Hattori; Hikaru Nakamura; Tomio Takeuchi; Y Iitaka
New antibiotic produced by Micromonospora globosa.
The Journal of antibiotics 1990;43(8):1000-5.
1990: Y Takahashi; Hikaru Nakamura; R Ogata; N Matsuda; M Hamada; Hiroshi Naganawa; T Takita; Y Iitaka; K Sato; Tomio Takeuchi
Kijimicin, a polyether antibiotic.
The Journal of antibiotics 1990;43(4):441-3.
1990: S Yoshida; Y Nakamura; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi
Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. II. Structure determination of probestin.
The Journal of antibiotics 1990;43(2):149-53.
1990: S Atsumi; Kazuo Umezawa; Hironobu Iinuma; Hiroshi Naganawa; Hikaru Nakamura; Y Iitaka; Tomio Takeuchi
Production, isolation and structure determination of a novel beta-glucosidase inhibitor, cyclophellitol, from Phellinus sp.
The Journal of antibiotics 1990;43(1):49-53.
1989: T Onoda; Hironobu Iinuma; Y Sasaki; M Hamada; K Isshiki; Hiroshi Naganawa; Tomio Takeuchi; K Tatsuta; Kazuo Umezawa
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
Journal of natural products 1989;52(6):1252-7.
1989: K Kiyoshima; M Sakamoto; H Nomura; T Yoshioka; R Okamoto; T Sawa; Hiroshi Naganawa; Tomio Takeuchi
Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes.
The Journal of antibiotics 1989;42(11):1661-72.
1989: A Takahashi; Daishiro Ikeda; Hikaru Nakamura; Hiroshi Naganawa; S Kurasawa; Yoshiro Okami; Tomio Takeuchi
Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.
The Journal of antibiotics 1989;42(11):1562-6.
1989: H Nishioka; M Imoto; T Sawa; M Hamada; Hiroshi Naganawa; Tomio Takeuchi; Kazuo Umezawa
Screening of phosphatidylinositol kinase inhibitors from Streptomyces.
The Journal of antibiotics 1989;42(5):823-5.
1989: K Kiyoshima; M Sakamoto; T Ishikura; Y Fukagawa; T Yoshioka; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.
Chemical & pharmaceutical bulletin 1989;37(4):861-5.
1989: K Dobashi; J X Yang; R Ogata; Y Takahashi; N Matsuda; M Hamada; Hiroshi Naganawa; T Takita; Tomio Takeuchi
The structure of hidamicin, a polyether antibiotic.
The Journal of antibiotics 1989;42(4):629-32.
1989: Hiroshi Naganawa; Y Kadokura; Yasuhiko Muraoka; T Nakatani; T Takita
Carbon-13 NMR assignment of peplomycin.
The Journal of antibiotics 1989;42(4):633-6.
1989: K Isshiki; T Sawa; Hiroshi Naganawa; N Matsuda; S Hattori; M Hamada; Tomio Takeuchi; M Oosono; M Ishizuka; Z Z Yang
3-O-isobutyrylkinamycin C and 4-deacetyl-4-O-isobutyrylkinamycin C, new antibiotics produced by a Saccharothrix species.
The Journal of antibiotics 1989;42(3):467-9.
1988: T Yoshioka; K Kiyoshima; M Maeda; M Sakamoto; T Ishikura; Y Fukagawa; T Sawa; M Hamada; Hiroshi Naganawa; Tomio Takeuchi
Synthesis and structure-activity studies of new 4''-O-acyltylosin derivatives of therapeutic interest.
The Journal of antibiotics 1988;41(11):1617-28.
1988: K Dobashi; Hiroshi Naganawa; Y Takahashi; T Takita; Tomio Takeuchi
Novel antifungal antibiotics octacosamicins A and B. II. The structure elucidation using various NMR spectroscopic methods.
The Journal of antibiotics 1988;41(11):1533-41.
1988: K Dobashi; N Matsuda; M Hamada; Hiroshi Naganawa; T Takita; Tomio Takeuchi
Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1988;41(11):1525-32.
1988: A Takahashi; Hikaru Nakamura; Daishiro Ikeda; Hiroshi Naganawa; T Kameyama; S Kurasawa; Yoshiro Okami; Tomio Takeuchi; Y Iitaka
Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination.
The Journal of antibiotics 1988;41(11):1568-74.
1988: Y Shigihara; Y Koizumi; T Tamamura; Y Homma; K Isshiki; K Dobashi; Hiroshi Naganawa; Tomio Takeuchi
6-Deoxy-8-O-methylrabelomycin and 8-O-methylrabelomycin from a Streptomyces species.
The Journal of antibiotics 1988;41(9):1260-4.
1988: S Yoshida; Hiroshi Naganawa; T Aoyagi; Tomio Takeuchi; H Umezawa
Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination.
The Journal of antibiotics 1988;41(8):1015-8.
1988: Tomio Takeuchi; T Hara; Hiroshi Naganawa; M Okada; M Hamada; H Umezawa; S Gomi; M Sezaki; S Kondo
New antifungal antibiotics, benanomicins A and B from an actinomycete.
The Journal of antibiotics 1988;41(6):807-11.
1988: M Imoto; T Yamashita; T Sawa; S Kurasawa; Hiroshi Naganawa; Tomio Takeuchi; Z Bao-quan; Kazuo Umezawa
Inhibition of cellular phosphatidylinositol turnover by psi-tectorigenin.
FEBS letters 1988;230(1-2):43-6.
1988: T Uchida; M Imoto; Y Takahashi; A Odagawa; T Sawa; K Tatsuta; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; H Umezawa
New potent anthracyclines, barminomycins I and II.
The Journal of antibiotics 1988;41(3):404-8.
1987: K Shiomi; Hironobu Iinuma; Hiroshi Naganawa; K Isshiki; Tomio Takeuchi; H Umezawa
Biosynthesis of napyradiomycins.
The Journal of antibiotics 1987;40(12):1740-5.
1987: A Takahashi; Hikaru Nakamura; T Kameyama; S Kurasawa; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi; H Umezawa; Y Iitaka
Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. II. Physico-chemical properties and structure determination.
The Journal of antibiotics 1987;40(12):1671-6.
1987: M Kitahara; M Asano; Hiroshi Naganawa; K Maeda; M Hamada; T Aoyagi; H Umezawa; Y Iitaka; Hikaru Nakamura
Valilactone, an inhibitor of esterase, produced by actinomycetes.
The Journal of antibiotics 1987;40(11):1647-50.
1987: K Isshiki; Y Takahashi; Hironobu Iinuma; Hiroshi Naganawa; Y Umezawa; Tomio Takeuchi; H Umezawa; S Nishimura; N Okada; K Tatsuta
Synthesis of azepinomycin and its beta-D-ribofuranoside.
The Journal of antibiotics 1987;40(10):1461-3.
1987: Tomio Takeuchi; T Sawa; Hiroshi Naganawa; M Hamada; H Umezawa; T Yoshioka; K Kiyoshima; H Iguchi; M Sakamoto; Y Shimauchi
4''-O-(4-methoxyphenyl)-acetyltylosin, a new macrolide derivative of therapeutic importance.
The Journal of antibiotics 1987;40(9):1358-60.
1987: K Shiomi; Hikaru Nakamura; Hironobu Iinuma; Hiroshi Naganawa; Tomio Takeuchi; H Umezawa; Y Iitaka
New antibiotic napyradiomycins A2 and B4 and stereochemistry of napyradiomycins.
The Journal of antibiotics 1987;40(9):1213-9.
1987: K Isshiki; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi; H Umezawa; K Tatsuta
Total synthesis of indisocin and N-methylindisocin.
The Journal of antibiotics 1987;40(8):1202-3.
1987: K Isshiki; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi; H Umezawa; K Tatsuta
One-pot preparation of 1-chlorovinylisocyanides from carbonyl compounds.
The Journal of antibiotics 1987;40(8):1199-201.
1987: K Isshiki; Y Takahashi; M Okada; T Sawa; M Hamada; Hiroshi Naganawa; T Takita; Tomio Takeuchi; H Umezawa; M Yamamoto
A new antibiotic indisocin and N-methylindisocin.
The Journal of antibiotics 1987;40(8):1195-8.
1987: K Kiyoshima; K Takada; M Yamamoto; K Kubo; R Okamoto; Y Fukagawa; T Ishikura; Hiroshi Naganawa; T Sawa; Tomio Takeuchi
New tylosin analogs produced by mutants of Streptomyces fradiae.
The Journal of antibiotics 1987;40(8):1123-30.
1986: K Isshiki; T Tamamura; T Sawa; Hiroshi Naganawa; Tomio Takeuchi; H Umezawa
Biosynthetic studies of terpentecin.
The Journal of antibiotics 1986;39(11):1634-5.
1985: K Isshiki; T Tamamura; Y Takahashi; T Sawa; Hiroshi Naganawa; Tomio Takeuchi; H Umezawa
The structure of a new antibiotic, terpentecin.
The Journal of antibiotics 1985;38(12):1819-21.
1985: T Tamamura; T Sawa; K Isshiki; T Masuda; Y Homma; H Inuma; Hiroshi Naganawa; M Hamada; Tomio Takeuchi; H Umezawa
Isolation and characterization of terpentecin, a new antitumor antibiotic.
The Journal of antibiotics 1985;38(12):1664-9.
1985: F Kanai; K Isshiki; Y Umezawa; H Morishima; Hiroshi Naganawa; T Takita; Tomio Takeuchi; H Umezawa
Vanoxonin, a new inhibitor of thymidylate synthetase. II. Structure determination and total synthesis.
The Journal of antibiotics 1985;38(1):31-8.
1982: R Okamoto; K Kiyoshima; M Yamamoto; K Takada; T Ohnuki; T Ishikura; Hiroshi Naganawa; K Tatsuta; Tomio Takeuchi; H Umezawa
New macrolide antibiotics produced by mutants from Streptomyces fradiae NRRL 2702.
The Journal of antibiotics 1982;35(7):921-4.