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Kazuya Nagano

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K Yamashita; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; H Aoshima; M Aoyama; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; T Nagano; T Ogura; H Pan; M Taira; Shin-ichi Tsunoda; Yasuo Tsutsumi
Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration.
T Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Toshiro Hirai; Haruhiko Kamada; Sayuri Kondoh; Keigo Matsuyama; Hiromi Nabeshi; Kazuya Nagano; Yasutaro Nakazato; Saeko Tochigi; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells.
T Nagano; Shin-ichi Tsunoda; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; K Hata; K Higashisaka; Haruhiko Kamada; A Kunieda; Hiromi Nabeshi; Kazuya Nagano; Yasuo Tsutsumi
Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure.

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All Publications

2013: K Yamashita; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; H Aoshima; M Aoyama; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; T Nagano; T Ogura; H Pan; M Taira; Shin-ichi Tsunoda; Yasuo Tsutsumi
Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration.
Die Pharmazie 2013;68(1):54-7.
2012: T Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Toshiro Hirai; Haruhiko Kamada; Sayuri Kondoh; Keigo Matsuyama; Hiromi Nabeshi; Kazuya Nagano; Yasutaro Nakazato; Saeko Tochigi; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells.
Biochemical and biophysical research communications 2012;427(4):748-52.
2012: T Nagano; Shin-ichi Tsunoda; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; K Hata; K Higashisaka; Haruhiko Kamada; A Kunieda; Hiromi Nabeshi; Kazuya Nagano; Yasuo Tsutsumi
Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure.
Die Pharmazie 2012;67(11):958-9.
2012: Toshiro Hirai; Ko-ichi Ichihashi; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; Hideki Takahashi; Saeko Tochigi; Shin-ichi Tsunoda; T Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Yasuo Tsutsumi
Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells.
Biochemical and biophysical research communications 2012;427(3):553-6.
2012: Takuya Yamashita; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuo Tsutsumi; Yasuhiro Abe; Takeshi Furuya; Masaki Inoue; Norio Itoh; Haruhiko Kamada; So-ichiro Kanasaki; Yuka Maeda; Hiromi Nabeshi; Kazuya Nagano; Shin-ichi Tsunoda
Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells.
Biochemical and biophysical research communications 2012;421(1):140-4.
2012: Yuki Morishita; Hiromi Nabeshi; Kazuya Nagano; Nao Nojiri; Hiroyoshi Satoh; Shin-ichi Tsunoda; Yasuhiro Abe; Haruhiko Kamada; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuo Tsutsumi
Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice.
Biochemical and biophysical research communications 2012;420(2):297-301.
2012: Toshihide Yamashita; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuo Tsutsumi; Yasuhiro Abe; S Imai; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; T Okamura; Shin-ichi Tsunoda
Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.
Die Pharmazie 2012;67(3):253-5.
2012: Kazuma Higashisaka; Haruhiko Kamada; Akiyoshi Kunieda; Yuki Morishita; Hiromi Nabeshi; Kazuya Nagano; Takashi Nagano; Toshinobu Ogura; Huiyan Pan; Shin-Ichi Tsunoda; Kohei Yamashita; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Yasuo Tsutsumi
Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles.
Nanoscale research letters 2012;7(1):555.
2012: Toshiro Hirai; Ko-ichi Ichihashi; Norio Itoh; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; Saeko Tochigi; Shin-ichi Tsunoda; Miyuki Uji; Tokuyuki Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Takanori Akase; Yasuo Tsutsumi
Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection.
Particle and fibre toxicology 2012;9():3.
2011: T Hirai; K Ichihashi; Norio Itoh; Haruhiko Kamada; Hiromi Nabeshi; Kazuya Nagano; S Tochigi; Shin-ichi Tsunoda; M Uji; K Yamashita; T Yamashita; T Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; T Akase; Yasuo Tsutsumi
Size-dependent immune-modulating effect of amorphous nanosilica particles.
Die Pharmazie 2011;66(9):727-8.
2011: Kohei Yamashita; Yasuo Yoshioka; Kazuma Higashisaka; Kazuya Mimura; Yuki Morishita; Masatoshi Nozaki; Tokuyuki Yoshida; Toshinobu Ogura; Hiromi Nabeshi; Kazuya Nagano; Yasuhiro Abe; Haruhiko Kamada; Youko Monobe; Takayoshi Imazawa; Hisae Aoshima; Kiyoshi Shishido; Yuichi Kawai; Tadanori Mayumi; Shin-Ichi Tsunoda; Norio Itoh; Tomoaki Yoshikawa; Itaru Yanagihara; Shigeru Saito; Yasuo Tsutsumi
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice.
Nature nanotechnology 2011;6(5):321-8.
2011: Hiromi Nabeshi; Tomoaki Yoshikawa; Keigo Matsuyama; Yasutaro Nakazato; Kazuhiko Matsuo; Akihiro Arimori; Masaaki Isobe; Saeko Tochigi; Sayuri Kondoh; Toshiro Hirai; Takanori Akase; Takuya Yamashita; Kohei Yamashita; Tokuyuki Yoshida; Kazuya Nagano; Yasuhiro Abe; Yasuo Yoshioka; Haruhiko Kamada; Takayoshi Imazawa; Norio Itoh; Shinsaku Nakagawa; Tadanori Mayumi; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application.
Biomaterials 2011;32(11):2713-24.
2011: Tetsuya Nomura; Yasuhiro Abe; Haruhiko Kamada; Hiroko Shibata; Hiroyuki Kayamuro; Masaki Inoue; Tomoyuki Kawara; Shuhei Arita; Takeshi Furuya; Takuya Yamashita; Kazuya Nagano; Tomoaki Yoshikawa; Yasuo Yoshioka; Yohei Mukai; Shinsaku Nakagawa; Madoka Taniai; Tsunetaka Ohta; Satoshi Serada; Tetsuji Naka; Shin-ichi Tsunoda; Yasuo Tsutsumi
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.
Journal of controlled release : official journal of the Controlled Release Society 2011;149(1):8-14.
2011: Hiromi Nabeshi; Kazuya Nagano; Saeko Tochigi; Shin-Ichi Tsunoda; Miyuki Uji; Takuya Yamashita; Tokuyuki Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuhiro Abe; Takanori Akase; Kazuma Higashisaka; Toshiro Hirai; Ko-Ichi Ichihashi; Norio Itoh; Haruhiko Kamada; Yuki Morishita; Yasuo Tsutsumi
Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages.
Nanoscale research letters 2011;6(1):464.
2011: Tokuyuki Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Kohei Yamashita; Yasuhiro Abe; Maho Fujimura; Kazuma Higashisaka; Norio Itoh; Haruhiko Kamada; Hiroyuki Kayamuro; Yuki Morishita; Hiromi Nabeshi; Kazuya Nagano; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice.
Nanoscale research letters 2011;6(1):195.
2011: Hiromi Nabeshi; Kazuya Nagano; Saeko Tochigi; Shin-Ichi Tsunoda; Yasuhiro Abe; Takanori Akase; Akihiro Arimori; Toshiro Hirai; Norio Itoh; Haruhiko Kamada; Tokuyuki Yoshida; Tomoaki Yoshikawa; Yasuo Yoshioka; Yasuo Tsutsumi
Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages.
Nanoscale research letters 2011;6(1):93.
2011: Hiromi Nabeshi; Tomoaki Yoshikawa; Keigo Matsuyama; Yasutaro Nakazato; Saeko Tochigi; Sayuri Kondoh; Toshiro Hirai; Takanori Akase; Kazuya Nagano; Yasuhiro Abe; Yasuo Yoshioka; Haruhiko Kamada; Norio Itoh; Shin-ichi Tsunoda; Yasuo Tsutsumi
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.
Particle and fibre toxicology 2011;8():1.
2011: Kazuma Higashisaka; Yasuo Yoshioka; Kohei Yamashita; Yuki Morishita; Maho Fujimura; Hiromi Nabeshi; Kazuya Nagano; Yasuhiro Abe; Haruhiko Kamada; Shin-ichi Tsunoda; Tomoaki Yoshikawa; Norio Itoh; Yasuo Tsutsumi
Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials.
Biomaterials 2011;32(1):3-9.
2010: Tokuyuki Yoshida; Yasuo Yoshioka; Maho Fujimura; Kohei Yamashita; Kazuma Higashisaka; Ryosuke Nakanishi; Yuki Morishita; Hiroyuki Kayamuro; Hiromi Nabeshi; Kazuya Nagano; Yasuhiro Abe; Haruhiko Kamada; Shinichi Tsunoda; Tomoaki Yoshikawa; Norio Itoh; Yasuo Tsutsumi
Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.
Toxicology letters 2010;199(3):383-8.
2010: Hiromi Nabeshi; Tomoaki Yoshikawa; Haruhiko Kamada; Hiroko Shibata; Toshiki Sugita; Yasuhiro Abe; Kazuya Nagano; Tetsuya Nomura; K Minowa; Shin-ichi Tsunoda; Yasuo Tsutsumi
Arsenic trioxide induces down-regulation of gp46 via protein oxidation: proteomics analysis of oxidative modified proteins in As2O3-treated HTLV-1-infected cells.
Die Pharmazie 2010;65(9):702-7.
2010: Kohei Yamashita; Yasuo Yoshioka; Kazuma Higashisaka; Yuki Morishita; Tokuyuki Yoshida; Maho Fujimura; Hiroyuki Kayamuro; Hiromi Nabeshi; Takuya Yamashita; Kazuya Nagano; Yasuhiro Abe; Haruhiko Kamada; Yuichi Kawai; Tadanori Mayumi; Tomoaki Yoshikawa; Norio Itoh; Shin-ichi Tsunoda; Yasuo Tsutsumi
Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape.
Inflammation 2010;33(4):276-80.
2010: H Kayamuro; Yasuhiro Abe; Yasuo Yoshioka; Kazufumi Katayama; T Yoshida; K Yamashita; Tomoaki Yoshikawa; Y Kawai; Tadanori Mayumi; Takachika Hiroi; Norio Itoh; Kazuya Nagano; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi
Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV.
Die Pharmazie 2010;65(4):254-6.
2010: Kazuya Nagano; Hiromi Nabeshi; Shin-Ichi Tsunoda
[Forefront researches of drug innovation technology in the post-genomic era--studies of biomarker discovery for drug development].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(4):463-4.
2010: Hiromi Nabeshi; Tomoaki Yoshikawa; K Matsuyama; Y Nakazato; A Arimori; M Isobe; S Tochigi; S Kondoh; T Hirai; T Akase; T Yamashita; K Yamashita; T Yoshida; Kazuya Nagano; Yasuhiro Abe; Yasuo Yoshioka; Haruhiko Kamada; T Imazawa; Norio Itoh; Shin-ichi Tsunoda; Yasuo Tsutsumi
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells.
Die Pharmazie 2010;65(3):199-201.
2010: Tokuyuki Yoshida; Yasuo Yoshioka; Maho Fujimura; Hiroyuki Kayamuro; Kohei Yamashita; Kazuma Higashisaka; Ryosuke Nakanishi; Yuki Morishita; Hiromi Nabeshi; Takuya Yamashita; Masashi Muroi; Kenichi Tanamoto; Kazuya Nagano; Yasuhiro Abe; Haruhiko Kamada; Yuichi Kawai; Tadanori Mayumi; Norio Itoh; Tomoaki Yoshikawa; Shinichi Tsunoda; Yasuo Tsutsumi
Urban aerosols induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo.
Biological & pharmaceutical bulletin 2010;33(5):780-3.
2009: Hiroyuki Kayamuro; Yasuhiro Abe; Yasuo Yoshioka; Kazufumi Katayama; Tetsuya Nomura; Tokuyuki Yoshida; Kohei Yamashita; Tomoaki Yoshikawa; Yuichi Kawai; Tadanori Mayumi; Takachika Hiroi; Norio Itoh; Kazuya Nagano; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses.
Biomaterials 2009;30(29):5869-76.
2009: Hiromi Nabeshi; Tomoaki Yoshikawa; Haruhiko Kamada; Hiroko Shibata; Toshiki Sugita; Yasuhiro Abe; Kazuya Nagano; Tetsuya Nomura; Kyoko Minowa; Takuya Yamashita; Norio Itoh; Yasuo Yoshioka; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Arsenic trioxide inhibits human t cell-lymphotropic virus-1-induced syncytiums by down-regulating gp46.
Biological & pharmaceutical bulletin 2009;32(7):1286-8.
2009: Sunao Imai; Y Yoshida; T Okamura; Kazuya Nagano; Yasuhiro Abe; Tomoaki Yoshikawa; Haruhiko Kamada; Shinsaku Nakagawa; Shin-ichi Tsunoda; Yasuo Tsutsumi
The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells.
Die Pharmazie 2009;64(3):214-6.
2008: Sunao Imai; Yohei Mukai; T Takeda; Yasuhiro Abe; Kazuya Nagano; Haruhiko Kamada; Shinsaku Nakagawa; Shin-ichi Tsunoda; Yasuo Tsutsumi
Effect of protein properties on display efficiency using the M13 phage display system.
Die Pharmazie 2008;63(10):760-4.
2008: Tomoaki Yoshikawa; Toshiki Sugita; Yohei Mukai; Natsue Yamanada; Kazuya Nagano; Hiromi Nabeshi; Yasuo Yoshioka; Shinsaku Nakagawa; Yasuhiro Abe; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi
Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.
Journal of molecular biology 2008;380(5):777-82.
2008: Toshiki Sugita; T Yoshikawa; Yohei Mukai; N Yamanada; Sunao Imai; Kazuya Nagano; Y Yoshida; Hiroko Shibata; Y Yoshioka; Shinsaku Nakagawa; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi
Comparative study on transduction and toxicity of protein transduction domains.
British journal of pharmacology 2008;153(6):1143-52.
2007: Toshiki Sugita; Tomoaki Yoshikawa; Yohei Mukai; Natsue Yamanada; Sunao Imai; Kazuya Nagano; Yasunobu Yoshida; Hiroko Shibata; Yasuo Yoshioka; Shinsaku Nakagawa; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi
Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide.
Biochemical and biophysical research communications 2007;363(4):1027-32.
2007: Haruhiko Kamada; Takayuki Okamoto; Maki Kawamura; Hiroko Shibata; Yasuhiro Abe; Akiko Ohkawa; Tetsuya Nomura; Masaki Sato; Yohei Mukai; Toshiki Sugita; Sunao Imai; Kazuya Nagano; Yasuo Tsutsumi; Shinsaku Nakagawa; Tadanori Mayumi; Shin-ichi Tsunoda
Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain.
Biological & pharmaceutical bulletin 2007;30(2):218-23.
2006: Yohei Mukai; Toshiki Sugita; Tomoko Yamato; Natsue Yamanada; Hiroko Shibata; Sunao Imai; Yasuhiro Abe; Kazuya Nagano; Tetsuya Nomura; Yasuo Tsutsumi; Haruhiko Kamada; Shinsaku Nakagawa; Shin-ichi Tsunoda
Creation of novel Protein Transduction Domain (PTD) mutants by a phage display-based high-throughput screening system.
Biological & pharmaceutical bulletin 2006;29(8):1570-4.
2006: Maki Kawamura; Hiroko Shibata; Haruhiko Kamada; Takayuki Okamoto; Yohei Mukai; Toshiki Sugita; Yasuhiro Abe; Sunao Imai; Tetsuya Nomura; Kazuya Nagano; Tadanori Mayumi; Shinsaku Nakagawa; Yasuo Tsutsumi; Shin-ich Tsunoda
A novel method for construction of gene fragment library to searching epitopes.
Biochemical and biophysical research communications 2006;346(1):198-204.
2006: Sunao Imai; Yohei Mukai; Kazuya Nagano; Hiroko Shibata; Toshiki Sugita; Yasuhiro Abe; Tetsuya Nomura; Yasuo Tsutsumi; Haruhiko Kamada; Shinsaku Nakagawa; Shin-ichi Tsunoda
Quality enhancement of the non-immune phage scFv library to isolate effective antibodies.
Biological & pharmaceutical bulletin 2006;29(7):1325-30.