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M Nagao

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Naoko Watanabe; Eriko Okochi; Y Hirayama; Y Shimada; K Yanagihara; M C Yoshida; S Takahashi; M Mochizuki; Takashi Sugimura; M Nagao; Toshikazu Ushijima
Single nucleotide instability without microsatellite instability in rat mammary carcinomas.
T Kuramoto; K Kitada; T Inui; Y Sasaki; K Ito; T Hase; S Kawagachi; Y Ogawa; K Nakao; G S Barsh; M Nagao; Toshikazu Ushijima; T Serikawa
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.
GR Stuart; E Thorleifson; Eriko Okochi; Johan G de Boer; Toshikazu Ushijima; M Nagao; Barry W Glickman
Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue rats.

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All Publications

2001: Naoko Watanabe; Eriko Okochi; Y Hirayama; Y Shimada; K Yanagihara; M C Yoshida; S Takahashi; M Mochizuki; Takashi Sugimura; M Nagao; Toshikazu Ushijima
Single nucleotide instability without microsatellite instability in rat mammary carcinomas.
Cancer research 2001;61(6):2632-40.
2001: T Kuramoto; K Kitada; T Inui; Y Sasaki; K Ito; T Hase; S Kawagachi; Y Ogawa; K Nakao; G S Barsh; M Nagao; Toshikazu Ushijima; T Serikawa
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):559-64.
2000: GR Stuart; E Thorleifson; Eriko Okochi; Johan G de Boer; Toshikazu Ushijima; M Nagao; Barry W Glickman
Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue rats.
Mutation research 2000;452(1):101-21.
2000: Toshikazu Ushijima; M Yamamoto; M Suzui; Takashi Kuramoto; Y Yoshida; Tomoko Nomoto; Masae Tatematsu; Takashi Sugimura; M Nagao
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer research 2000;60(4):1092-6.
1999: Eriko Okochi; Naoko Watanabe; Y Shimada; S Takahashi; Kuniko Wakazono; T Shirai; Takashi Sugimura; M Nagao; Toshikazu Ushijima
Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine.
Carcinogenesis 1999;20(10):1933-8.
1999: Yoshikazu Hirayama; Kuniko Wakazono; M Yamamoto; M Kitano; Masae Tatematsu; M Nagao; Takashi Sugimura; Toshikazu Ushijima
Rare mutations of p53, Ki-ras, and beta-catenin genes and absence of K-sam and c-erbB-2 amplification in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach cancers.
Molecular carcinogenesis 1999;25(1):42-7.
1999: M Suzui; Toshikazu Ushijima; R H Dashwood; N Yoshimi; Takashi Sugimura; H Mori; M Nagao
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.
Molecular carcinogenesis 1999;24(3):232-7.
1999: Y Yoshida; Toshikazu Ushijima; S Yamashita; Kohzoh Imai; Takashi Sugimura; M Nagao
Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):610-5.
1999: Yoshikazu Hirayama; Toshikazu Ushijima; Takashi Kuramoto; M Kitano; Takashi Sugimura; M Nagao
Linkage mapping of the rat Msh2 DNA mismatch repair gene on chromosome 6.
Experimental animals / Japanese Association for Laboratory Animal Science 1999;48(1):63-4.
1998: Toshikazu Ushijima; Tomoko Nomoto; Takashi Sugimura; D E Housman; M Nagao
Isolation of 48 genetic markers appropriate for high throughput genotyping of inbred rat strains by B1 repetitive sequence-representational difference analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(12):1008-12.
1998: S Yamada; H Shima; M Toyota; Toshikazu Ushijima; Takashi Kuramoto; T Serikawa; K Okada; K Sato; Takashi Sugimura; M Nagao; H Nakagama
Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes.
Japanese journal of cancer research : Gann 1998;89(10):1014-9.
1998: M Nagao; M Ochiai; Toshikazu Ushijima; M Watanabe; Takashi Sugimura; H Nakagama
Genetic determinant and environmental carcinogens.
Mutation research 1998;402(1-2):85-91.
1998: M Nagao; H Fujita; M Ochiai; K Wakabayashi; T Sofuni; T Matsushima; Takashi Sugimura; Toshikazu Ushijima
No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice.
Mutation research 1998;400(1-2):251-7.
1998: R H Dashwood; M Suzui; H Nakagama; Takashi Sugimura; M Nagao
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.
Cancer research 1998;58(6):1127-9.
1997: H Okonogi; GR Stuart; Eriko Okochi; Toshikazu Ushijima; Takashi Sugimura; Barry W Glickman; M Nagao
Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.
Mutation research 1997;395(2-3):93-9.
1997: M Suzui; Toshikazu Ushijima; N Yoshimi; H Nakagama; A Hara; Takashi Sugimura; M Nagao; H Mori
No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate.
Molecular carcinogenesis 1997;20(4):389-93.
1997: Toshikazu Ushijima; M Nagao
[Representational difference analysis: its principle and versatile applications].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(11):1828-39.
1997: S Yamada; H Nakagama; M Toyota; Toshikazu Ushijima; K Sato; Takashi Sugimura; M Nagao
Linkage mapping of rat Rb1 gene on chromosome 15.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(6):454-5.
1997: M Nagao; Toshikazu Ushijima; M Toyota; R Inoue; T Sugimura
Genetic changes induced by heterocyclic amines.
Mutation research 1997;376(1-2):161-7.
1997: H Okonogi; Toshikazu Ushijima; X B Zhang; John A Heddle; T Suzuki; T Sofuni; J S Felton; James Tucker; Takashi Sugimura; M Nagao
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.
Carcinogenesis 1997;18(4):745-8.
1997: Toshikazu Ushijima; Keiichirou Morimura; Y Hosoya; H Okonogi; Masae Tatematsu; Takashi Sugimura; M Nagao
Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2284-9.
1997: S Yamada; H Nakagama; M Toyota; Toshikazu Ushijima; K Okada; K Sato; Takashi Sugimura; M Nagao
Cloning of rat Brca2 and linkage mapping to chromosome 12.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(11):850-1.
1997: H Okonogi; Toshikazu Ushijima; H Shimizu; Takashi Sugimura; M Nagao
Induction of aberrant crypt foci in C57BL/6N mice by 2-amino-9H-pyrido[2,3-b]indole (A alphaC) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Cancer letters 1997;111(1-2):105-9.
1996: Y Osawa; H Nakagama; H Shima; T Sugimura; M Nagao
Identification and characterization of three isotypes of protein phosphatase inhibitor-2 and their expression profiles during testis maturation in rats.
European journal of biochemistry / FEBS 1996;242(3):793-8.
1996: M Ochiai; H Nakagama; M Watanabe; Y Ishiguro; T Sugimura; M Nagao
Efficient method for rapid induction of aberrant crypt foci in rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Japanese journal of cancer research : Gann 1996;87(10):1029-33.
1996: F Canzian; Toshikazu Ushijima; M Toyota; T Sugimura; M Nagao
Linkage mapping of the rat Tp53 gene on chromosome 10.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(8):630.
1996: F Canzian; Toshikazu Ushijima; M Toyota; Y Hosoya; T Sugimura; M Nagao
Identification of 29 rat genetic markers by arbitrarily primed polymerase chain reaction.
Japanese journal of cancer research : Gann 1996;87(7):669-75.
1996: R Inoue; Toshikazu Ushijima; M Katami; H Kushida; Keiji Wakabayashi; H Sato; M Asamoto; M Katsuki; T Sugimura; M Nagao
Rare activation of the human c-Ha-ras transgene of mice in hemangioendothelial sarcomas and liver tumors induced by Glu-P-1.
Japanese journal of cancer research : Gann 1996;87(6):583-8.
1996: M Nagao; Keiji Wakabayashi; Toshikazu Ushijima; M Toyota; Y Totsuka; T Sugimura
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
Environmental health perspectives 1996;104 Suppl 3():497-501.
1996: T Sugimura; M Nagao; K Wakabayashi
Carcinogenicity of food mutagens.
Environmental health perspectives 1996;104 Suppl 3():429-33.
1996: M Toyota; F Canzian; Toshikazu Ushijima; Y Hosoya; Takashi Kuramoto; T Serikawa; K Imai; T Sugimura; M Nagao
A rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3914-9.
1996: M Toyota; Toshikazu Ushijima; Hideki Kakiuchi; F Canzian; M Watanabe; K Imai; T Sugimura; M Nagao
Genetic alterations in rat colon tumors induced by heterocyclic amines.
Cancer 1996;77(8 Suppl):1593-7.
1996: K Sone; M Maeda; Keiji Wakabayashi; N Takeichi; M Mori; T Sugimura; M Nagao
Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride.
Hepatology (Baltimore, Md.) 1996;23(4):764-70.
1996: H Fukuda; H Shima; R F Vesonder; H Tokuda; H Nishino; S Katoh; S Tamura; T Sugimura; M Nagao
Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin.
Biochemical and biophysical research communications 1996;220(1):160-5.
1996: M Toyota; Toshikazu Ushijima; J H Weisburger; Y Hosoya; F Canzian; A Rivenson; K Imai; T Sugimura; M Nagao
Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Molecular carcinogenesis 1996;15(3):176-82.
1996: M Ochiai; M Watanabe; H Kushida; Keiji Wakabayashi; T Sugimura; M Nagao
DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis.
Carcinogenesis 1996;17(1):95-8.
1995: M Nagao; H Shima; M Nakayasu; T Sugimura
Protein serine/threonine phosphatases as binding proteins for okadaic acid.
Mutation research 1995;333(1-2):173-9.
1995: M Toyota; Toshikazu Ushijima; Hideki Kakiuchi; M Watanabe; K Imai; A Yachi; T Sugimura; M Nagao
cDNA cloning of the rat APC gene and assignment to chromosome 18.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(10):746-8.
1995: S Kaneko; H Shima; T Amagasa; M Takagi; T Sugimura; M Nagao
Analysis by in vitro mutagenesis of PP2A alpha okadaic acid responsive sequences.
Biochemical and biophysical research communications 1995;214(2):518-23.
1995: R Inoue; T Fukutomi; Toshikazu Ushijima; Y Matsumoto; T Sugimura; M Nagao
Germline mutation of BRCA1 in Japanese breast cancer families.
Cancer research 1995;55(16):3521-4.
1995: Toshikazu Ushijima; Y Hosoya; T Suzuki; T Sofuni; T Sugimura; M Nagao
A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity.
Mutation research 1995;334(3):283-92.
1995: F Canzian; Toshikazu Ushijima; M Nagao; I Matera; Giovanni Romeo; Isabella Ceccherini
Genetic mapping of the RET protooncogene on rat chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(6):433-5.
1995: M Hirose; Keiji Wakabayashi; M Ochiai; H Kushida; H Sato; T Sugimura; M Nagao
Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Japanese journal of cancer research : Gann 1995;86(6):516-22.
1995: N Akiyama; H Shima; Y Hatano; Y Osawa; T Sugimura; M Nagao
cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase.
European journal of biochemistry / FEBS 1995;230(2):766-72.
1995: F Canzian; Toshikazu Ushijima; R Pascale; T Sugimura; Tommaso A Dragani; M Nagao
Construction of a phylogenetic tree for inbred strains of rat by arbitrarily primed polymerase chain reaction (AP-PCR).
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(4):231-5.
1995: Hideki Kakiuchi; M Watanabe; Toshikazu Ushijima; M Toyota; K Imai; J H Weisburger; T Sugimura; M Nagao
Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):910-4.
1995: Toshikazu Ushijima; H Makino; Hideki Kakiuchi; R Inoue; T Sugimura; M Nagao
Genetic alterations in HCA-induced tumors.
Princess Takamatsu symposia 1995;23():281-91.
1995: Toshikazu Ushijima; H Makino; H Okonogi; Y Hosoya; T Sugimura; M Nagao
Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline.
Molecular carcinogenesis 1995;12(1):23-30.
1995: T Sugimura; R Inoue; H Ohgaki; Toshikazu Ushijima; F Canzian; M Nagao
Genetic polymorphisms and susceptibility to cancer development.
Pharmacogenetics 1995;5 Spec No():S161-5.
1994: F Canzian; Toshikazu Ushijima; T Serikawa; Keiji Wakabayashi; T Sugimura; M Nagao
Instability of microsatellites in rat colon tumors induced by heterocyclic amines.
Cancer research 1994;54(24):6315-7.
1994: Toshikazu Ushijima; Y Hosoya; M Ochiai; H Kushida; Keiji Wakabayashi; T Suzuki; M Hayashi; T Sofuni; T Sugimura; M Nagao
Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice.
Carcinogenesis 1994;15(12):2805-9.
1994: R Inoue; T Fukutomi; Toshikazu Ushijima; Y Matsumoto; T Sugimura; M Nagao
Linkage analysis of BRCA1 in Japanese breast cancer families.
Japanese journal of cancer research : Gann 1994;85(12):1233-9.
1994: H Shima; H Tohda; S Aonuma; M Nakayasu; A A DePaoli-Roach; T Sugimura; M Nagao
Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9267-71.
1994: H Tohda; A Yasui; T Yasumoto; M Nakayasu; H Shima; M Nagao; T Sugimura
Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.
Biochemical and biophysical research communications 1994;203(2):1210-6.
1994: M Watanabe; Toshikazu Ushijima; Hideki Kakiuchi; T Shiraishi; R Yatani; J Shimazaki; T Kotake; T Sugimura; M Nagao
p53 gene mutations in human prostate cancers in Japan: different mutation spectra between Japan and western countries.
Japanese journal of cancer research : Gann 1994;85(9):904-10.
1994: H Kushida; Keiji Wakabayashi; H Sato; M Katami; R Kurosaka; M Nagao
Dose-response study of MeIQx carcinogenicity in F344 male rats.
Cancer letters 1994;83(1-2):31-5.
1994: M Nagao; Toshikazu Ushijima; K Wakabayashi; M Ochiai; H Kushida; T Sugimura; R Hasegawa; T Shirai; N Ito
Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods.
Cancer 1994;74(3 Suppl):1063-9.
1994: A Tada; M Ochiai; Keiji Wakabayashi; Haruo Nukaya; T Sugimura; M Nagao
Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo.
Carcinogenesis 1994;15(6):1275-8.
1994: Toshikazu Ushijima; Hideki Kakiuchi; H Makino; R Hasegawa; Y Ishizaka; H Hirai; Y Yazaki; N Ito; T Sugimura; M Nagao
Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Molecular carcinogenesis 1994;10(1):38-44.
1994: H Makino; Toshikazu Ushijima; Hideki Kakiuchi; M Onda; N Ito; T Sugimura; M Nagao
Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine.
Japanese journal of cancer research : Gann 1994;85(5):510-4.
1994: Toshikazu Ushijima; H Makino; M Nakayasu; S Aonuma; M Takeuchi; K Segawa; T Sugimura; M Nagao
Presence of p53 mutations in 3Y1-B clone 1-6: a rat cell line widely used as a normal immortalized fibroblast.
Japanese journal of cancer research : Gann 1994;85(5):455-8.
1994: Y S Chun; H Shima; K Nagasaki; T Sugimura; M Nagao
PP1 gamma 2, a testis-specific protein-serine/threonine-phosphatase type 1 catalytic subunit, is associated with a protein having high sequence homology with the 78-kDa glucose-regulated protein, a member of the 70-kDa heat shock protein family.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3319-23.
1994: K Fukutome; M Ochiai; Keiji Wakabayashi; S Watanabe; T Sugimura; M Nagao
Detection of guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adduct as a single spot on thin-layer chromatography by modification of the 32P-postlabeling method.
Japanese journal of cancer research : Gann 1994;85(2):113-7.
1993: M Nagao; T Sugimura
Carcinogenic factors in food with relevance to colon cancer development.
Mutation research 1993;290(1):43-51.
1993: M Ochiai; H Nagaoka; Keiji Wakabayashi; Y Tanaka; S B Kim; A Tada; Haruo Nukaya; T Sugimura; M Nagao
Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx.
Carcinogenesis 1993;14(10):2165-70.
1993: H Sone; Keiji Wakabayashi; H Kushida; M Ochiai; T Sugimura; M Nagao
Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet.
Japanese journal of cancer research : Gann 1993;84(8):859-64.
1993: H Shima; T Haneji; Y Hatano; I Kasugai; T Sugimura; M Nagao
Protein phosphatase 1 gamma 2 is associated with nuclei of meiotic cells in rat testis.
Biochemical and biophysical research communications 1993;194(2):930-7.
1993: H Shima; Y Hatano; Y S Chun; T Sugimura; Zhongjian Zhang; E Y Lee; M Nagao
Identification of PP1 catalytic subunit isotypes PP1 gamma 1, PP1 delta and PP1 alpha in various rat tissues.
Biochemical and biophysical research communications 1993;192(3):1289-96.
1993: S E Shephard; Keiji Wakabayashi; M Nagao
Mutagenic activity of peptides and the artificial sweetener aspartame after nitrosation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(5):323-9.
1993: Keiji Wakabayashi; H Ushiyama; M Takahashi; Haruo Nukaya; S B Kim; M Hirose; M Ochiai; T Sugimura; M Nagao
Exposure to heterocyclic amines.
Environmental health perspectives 1993;99():129-34.
1993: Hideki Kakiuchi; Toshikazu Ushijima; M Ochiai; K Imai; N Ito; A Yachi; T Sugimura; M Nagao
Rare frequency of activation of the Ki-ras gene in rat colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis.
Molecular carcinogenesis 1993;8(1):44-8.
1993: M Nagao; H Shima; K Sasaki; Y Ishizaka; M Nakayasu; T Sugimura
cDNA cloning of serine/threonine phosphatase catalytic subunits and reversion of the malignant phenotype to the normal phenotype by okadaic acid, a protein phosphatase inhibitor.
Basic life sciences 1993;61():309-16.
1992: H Nagaoka; Keiji Wakabayashi; S B Kim; I S Kim; Y Tanaka; M Ochiai; A Tada; Haruo Nukaya; T Sugimura; M Nagao
Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.
Japanese journal of cancer research : Gann 1992;83(10):1025-9.
1992: R Kurosaka; Keiji Wakabayashi; H Ushiyama; Haruo Nukaya; N Arakawa; T Sugimura; M Nagao
Detection of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4,5-b]pyridine in broiled beef.
Japanese journal of cancer research : Gann 1992;83(9):919-22.
1992: Y Ishizaka; H Shima; T Sugimura; M Nagao
Detection of phosphorylated retTPC oncogene product in cytoplasm.
Oncogene 1992;7(7):1441-4.
1992: H Makino; Y Ishizaka; A Tsujimoto; T Nakamura; M Onda; T Sugimura; M Nagao
Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4850-4.
1992: F Itoh; Y Ishizaka; T Tahira; M Yamamoto; A Miya; K Imai; A Yachi; Shin-ichiro Takai; T Sugimura; M Nagao
Identification and analysis of the ret proto-oncogene promoter region in neuroblastoma cell lines and medullary thyroid carcinomas from MEN2A patients.
Oncogene 1992;7(6):1201-6.
1992: H Kushida; Keiji Wakabayashi; M Suzuki; S Takahashi; K Imaida; T Sugimura; M Nagao
Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611).
Carcinogenesis 1992;13(6):913-5.
1992: H Sone; Keiji Wakabayashi; H Kushida; T Sugimura; M Nagao
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
Carcinogenesis 1992;13(5):793-7.
1992: K Wakabayashi; M Nagao; H Esumi; T Sugimura
Food-derived mutagens and carcinogens.
Cancer research 1992;52(7 Suppl):2092s-2098s.
1992: H Makino; M Ochiai; Anne Caignard; Y Ishizaka; M Onda; T Sugimura; M Nagao
Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors.
Cancer letters 1992;62(2):115-21.
1991: T Tahira; Y Ishizaka; F Itoh; M Nakayasu; T Sugimura; M Nagao
Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid.
Oncogene 1991;6(12):2333-8.
1991: Y Ishizaka; M Takahashi; Toshikazu Ushijima; T Sugimura; M Nagao
A high phosphorylation state and increased activity of the TRE motif in the NIH3T3 cell transformant induced by retTPC.
Biochemical and biophysical research communications 1991;179(3):1331-6.
1991: Y Ishizaka; S Kobayashi; Toshikazu Ushijima; S Hirohashi; T Sugimura; M Nagao
Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method.
Oncogene 1991;6(9):1667-72.
1991: S Aonuma; Toshikazu Ushijima; M Nakayasu; H Shima; T Sugimura; M Nagao
Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium.
Mutation research 1991;250(1-2):375-81.
1991: Toshikazu Ushijima; M Tsutsumi; R Sakai; Y Ishizaka; F Takaku; Y Konishi; M Takahashi; T Sugimura; M Nagao
Ki-ras activation in pancreatic carcinomas of Syrian hamsters induced by N-nitrosobis(2-hydroxypropyl)amine.
Japanese journal of cancer research : Gann 1991;82(9):965-8.
1991: M Nagao; M Nakayasu; S Aonuma; Keiji Wakabayashi; M Hirose; T Sugimura
Mutagenic properties of 2-amino-N6-hydroxyadenine in Salmonella and in Chinese hamster lung cells in culture.
Mutation research 1991;253(1):97-102.
1991: Y Kitagawa; H Shima; K Sasaki; M Nagao
Identification of the promoter region of the rat protein phosphatase 2A alpha gene.
Biochimica et biophysica acta 1991;1089(3):339-44.
1991: M Nagao; M Nakayasu; S Aonuma; H Shima; T Sugimura
Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors.
Environmental health perspectives 1991;93():169-74.
1991: Y Ishizaka; T Tahira; Toshikazu Ushijima; F Ito; M Nagao
[Involvement of proto-ret and activated ret in human malignancy].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(7):1391-9.
1991: T Kaneko; H Shima; H Esumi; M Ochiai; S Nagase; T Sugimura; M Nagao
Marked increases of two kinds of two-exon-skipped albumin mRNAs with aging and their further increase by treatment with 3'-methyl-4-dimethylaminoazobenzene in Nagase analbuminemic rats.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2707-11.
1991: M Suzuki; K Wakabayashi; H Sone; H Kushida; K Sugiyama; T Kakizoe; M Nagao; T Sugimura
Inhibitory effect of 2-O-octadecylascorbic acid in agglutination assay with concanavalin A; short-term examination of rat urinary bladder carcinogenesis.
Japanese journal of cancer research : Gann 1991;82(4):386-9.
1991: M Ochiai; K Ogawa; Keiji Wakabayashi; T Sugimura; S Nagase; H Esumi; M Nagao
Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.
Japanese journal of cancer research : Gann 1991;82(4):363-6.
1991: E Overvik; M Ochiai; M Hirose; T Sugimura; M Nagao
The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines.
Mutation research 1991;256(1):37-43.
1991: Y Fujimoto; Y Ishizaka; T Tahira; H Sone; H Takahashi; K Enomoto; M Mori; T Sugimura; M Nagao
Possible involvement of c-myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats.
Molecular carcinogenesis 1991;4(4):269-74.
1990: T Tahira; M Shiraishi; Y Ishizaka; I Ikeda; R Sakai; T Sugimura; M Nagao
A TaqI RFLP in the human ret proto-oncogene.
Nucleic acids research 1990;18(24):7472.
1990: K Sasaki; H Shima; Y Kitagawa; S Irino; T Sugimura; M Nagao
Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas.
Japanese journal of cancer research : Gann 1990;81(12):1272-80.
1990: I Ikeda; Y Ishizaka; T Tahira; T Suzuki; M Onda; T Sugimura; M Nagao
Specific expression of the ret proto-oncogene in human neuroblastoma cell lines.
Oncogene 1990;5(9):1291-6.
1990: Y Kitagawa; K Sasaki; H Shima; M Shibuya; T Sugimura; M Nagao
Protein phosphatases possibly involved in rat spermatogenesis.
Biochemical and biophysical research communications 1990;171(1):230-5.
1990: T Tahira; M Nagao
[The c-raf oncogene].
Nihon rinsho. Japanese journal of clinical medicine 1990;48(8):98-103.
1990: K Sasaki; Y Kitagawa; H Shima; S Irino; T Sugimura; M Nagao
Production of shorter mRNA for protein phosphatase 2A beta by alternative poly(A) addition.
Biochemical and biophysical research communications 1990;170(1):169-75.
1990: M Hirose; Keiji Wakabayashi; S Grivas; Silvio De Flora; N Arakawa; M Nagao; T Sugimura
Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation.
Carcinogenesis 1990;11(5):869-71.
1990: P J Wirth; Y Fujimoto; H Takahashi; M Mori; M C Yoshida; T Sugimura; M Nagao
Two-dimensional electrophoretic analysis of hepatitis-associated polypeptides in liver of LEC rats developing spontaneous hepatitis.
Japanese journal of cancer research : Gann 1990;81(5):477-82.
1990: Y Ishizaka; Toshikazu Ushijima; T Sugimura; M Nagao
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line.
Biochemical and biophysical research communications 1990;168(2):402-8.
1990: M Nagao; Y Ishizaka; A Nakagawara; K Kohno; M Kuwano; T Tahira; F Itoh; I Ikeda; T Sugimura
Expression of ret proto-oncogene in human neuroblastomas.
Japanese journal of cancer research : Gann 1990;81(4):309-12.
1990: T Tahira; Y Ishizaka; F Itoh; T Sugimura; M Nagao
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.
Oncogene 1990;5(1):97-102.
1990: T Sugimura; K Wakabayashi; H Ohgaki; S Takayama; M Nagao; H Esumi
Heterocyclic amines produced in cooked food: unavoidable xenobiotics.
Princess Takamatsu symposia 1990;21():279-88.
1990: M Nagao; M Nakayasu; H Shima; S Aonuma; T Sugimura
Reversion of transformed NIH 3T3 cells to flat cells by inhibitors of poly(ADP-ribose) polymerase.
Basic life sciences 1990;52():401-5.
1989: R Sakai; I Ikeda; H Kitani; H Fujiki; F Takaku; U Rapp; T Sugimura; M Nagao
Flat reversion by okadaic acid of raf and ret-II transformants.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9946-50.
1989: Y Ishizaka; F Itoh; T Tahira; I Ikeda; T Sugimura; James Tucker; A Fertitta; A V Carrano; M Nagao
Human ret proto-oncogene mapped to chromosome 10q11.2.
Oncogene 1989;4(12):1519-21.
1989: Y Ishizaka; F Itoh; T Tahira; I Ikeda; T Ogura; T Sugimura; M Nagao
Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line.
Japanese journal of cancer research : Gann 1989;80(12):1149-52.
1989: K Takayama; K Yamashita; Keiji Wakabayashi; T Sugimura; M Nagao
DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.
Japanese journal of cancer research : Gann 1989;80(12):1145-8.
1989: H Shima; M Nakayasu; S Aonuma; T Sugimura; M Nagao
Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7442-5.
1989: Y Ishizaka; M Ochiai; T Tahira; T Sugimura; M Nagao
Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing.
Oncogene 1989;4(6):789-94.
1989: M Shioya; Keiji Wakabayashi; K Yamashita; M Nagao; T Sugimura
Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentaene-12 and -14.
Mutation research 1989;225(3):91-4.
1989: Keiji Wakabayashi; M Nagao; T Sugimura
Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite.
Cancer surveys 1989;8(2):385-99.
1989: Y Fujimoto; H Takahashi; K Dempo; M Mori; P J Wirth; M Nagao; T Sugimura
Hereditary hepatitis in LEC rats: accumulation of abnormally high ploid nuclei.
Cancer detection and prevention 1989;14(2):235-7.
1989: M Nagao; R Sakai; Y Kitagawa; I Ikeda; K Sasaki; H Shima; T Sugimura
Role of protein phosphatases in malignant transformation.
Princess Takamatsu symposia 1989;20():177-84.
1988: Y Kitagawa; R Sakai; T Tahira; H Tsuda; N Ito; T Sugimura; M Nagao
Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors.
Biochemical and biophysical research communications 1988;157(2):821-7.
1988: M Nakayasu; H Shima; S Aonuma; H Nakagama; M Nagao; T Sugimura
Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9066-70.
1988: F Ishikawa; R Sakai; M Ochiai; F Takaku; T Sugimura; M Nagao
Identification of a transforming activity suppressing sequence in the c-raf oncogene.
Oncogene 1988;3(6):653-8.
1988: Y Kitagawa; T Tahira; I Ikeda; K Kikuchi; S Tsuiki; T Sugimura; M Nagao
Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells.
Biochimica et biophysica acta 1988;951(1):123-9.
1988: K Yamashita; H Ohgaki; K Wakabayashi; M Nagao; T Sugimura
DNA adducts formed by the comutagens harman and norharman in various tissues of mice.
Cancer letters 1988;42(3):179-83.
1988: M Yano; K Wakabayashi; T Tahira; N Arakawa; M Nagao; T Sugimura
Presence of nitrosable mutagen precursors in cooked meat and fish.
Mutation research 1988;202(1):119-23.
1988: X M Zhang; K Wakabayashi; Z C Liu; T Sugimura; M Nagao
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.
Mutation research 1988;201(1):181-8.
1988: Y Ishizaka; T Tahira; M Ochiai; I Ikeda; T Sugimura; M Nagao
Molecular cloning and characterization of human ret-II oncogene.
Oncogene research 1988;3(2):193-7.
1988: T Tahira; Y Ishizaka; T Sugimura; M Nagao
Expression of proto-ret mRNA in embryonic and adult rat tissues.
Biochemical and biophysical research communications 1988;153(3):1290-5.
1988: T Tahira; H Ohgaki; Keiji Wakabayashi; M Nagao; T Sugimura
The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(6):511-6.
1988: I Ikeda; Y Ishizaka; M Ochiai; R Sakai; M Itabashi; M Onda; T Sugimura; M Nagao
No correlation between L-myc restriction fragment length polymorphism and malignancy of human colorectal cancers.
Japanese journal of cancer research : Gann 1988;79(6):674-6.
1988: F Ishikawa; R Sakai; M Ochiai; T Sugimura; M Nagao
Identification by a random linker insertion method of a region which suppresses the transforming activity of the raf oncogene.
Nucleic acids symposium series 1988;(19):39-42.
1987: Y Ishizaka; M Ochiai; F Ishikawa; S Sato; Y Miura; M Nagao; T Sugimura
Activated N-ras oncogene in a transformant derived from a rat small intestinal adenocarcinoma induced by 2-aminodipyrido[1,2-a:3',2'-d]imidazole.
Carcinogenesis 1987;8(11):1575-8.
1987: F Ishikawa; F Takaku; M Nagao; T Sugimura
The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf.
Oncogene research 1987;1(3):243-53.
1987: K Wakabayashi; M Nagao; M Ochiai; Y Fujita; T Tahira; M Nakayasu; H Ohgaki; S Takayama; T Sugimura
Recently identified nitrite-reactive compounds in food: occurrence and biological properties of the nitrosated products.
IARC scientific publications 1987;(84):287-91.
1986: K Wakabayashi; M Nagao; T Tahira; Z Yamaizumi; M Katayama; S Marumo; T Sugimura
4-Methoxyindole derivatives as nitrosable precursors of mutagens in Chinese cabbage.
Mutagenesis 1986;1(6):423-6.
1986: M Nagao; F Ishikawa; T Tahira; M Ochiai; T Sugimura
Activation of rat and human c-raf(-1) by rearrangement.
Princess Takamatsu symposia 1986;17():75-84.