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Bhushan Nagar

Research Profile

Chemicals & Drugs

Procedures

X Ray Crystallography

Concepts & Ideas

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Disorders

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Co-author Network

Publications

TOP 3
Markus A Seeliger; Bhushan Nagar; Filipp Frank; Xiaoxian Cao; M Nidanie Henderson; John Kuriyan
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty.
Bhushan Nagar; Oliver Hantschel; Markus A Seeliger; Jason M Davies; William I Weis; Giulio Superti-Furga; John Kuriyan
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Holger Sondermann; Bhushan Nagar; Dafna Bar-Sagi; John Kuriyan
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.

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All Publications

2007: Markus A Seeliger; Bhushan Nagar; Filipp Frank; Xiaoxian Cao; M Nidanie Henderson; John Kuriyan
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty.
Structure (London, England : 1993) 2007;15(3):299-311.
2006: Bhushan Nagar; Oliver Hantschel; Markus A Seeliger; Jason M Davies; William I Weis; Giulio Superti-Furga; John Kuriyan
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Molecular cell 2006;21(6):787-98.
2005: Holger Sondermann; Bhushan Nagar; Dafna Bar-Sagi; John Kuriyan
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16632-7.
2005: Bhushan Nagar; John Kuriyan
SAXS and the working protein.
Structure (London, England : 1993) 2005;13(2):169-70.
2003: Bhushan Nagar; Oliver Hantschel; Matthew Adam Young; Klaus Scheffzek; Darren R Veach; William G Bornmann; Bayard Clarkson; Giulio Superti-Furga; John Kuriyan
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Cell 2003;112(6):859-71.
2003: Oliver Hantschel; Bhushan Nagar; Sebastian Guettler; Jana Kretzschmar; Karel Dorey; John Kuriyan; Giulio Superti-Furga
A myristoyl/phosphotyrosine switch regulates c-Abl.
Cell 2003;112(6):845-57.
2003: S Mariana Margarit; Holger Sondermann; Brian E Hall; Bhushan Nagar; André Hoelz; Michelle Pirruccello; Dafna Bar-Sagi; John Kuriyan
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
Cell 2003;112(5):685-95.
2002: Neil P Shah; John M Nicoll; Bhushan Nagar; Mercedes E Gorre; Ronald L Paquette; John Kuriyan; Charles L Sawyers
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia.
Cancer cell 2002;2(2):117-25.
2002: David Wisniewski; Caryl L Lambek; Chongyuan Liu; Annabel Strife; Darren R Veach; Bhushan Nagar; Matthew Adam Young; Thomas Schindler; William G Bornmann; Joseph R Bertino; John Kuriyan; Bayard Clarkson
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.
Cancer research 2002;62(15):4244-55.
2002: Bhushan Nagar; William G Bornmann; Patricia Pellicena; Thomas Schindler; Darren R Veach; W Todd Miller; Bayard Clarkson; John Kuriyan
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).
Cancer research 2002;62(15):4236-43.