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Ram Nagaraj

Research Profile

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TOP 3
Rooban B Nahomi; Cibin T Raghavan; Puttur Santhoshkumar; Oliver H Voss; Benlian Wang; Andrea I Doseff; Ram H Nagaraj
Chaperone Peptides of α-Crystallin Inhibit Epithelial Cell Apoptosis, Protein Insolubilization, and Opacification in Experimental Cataracts.
Rooban B Nahomi; Tomoko Oya-Ito; Ram H Nagaraj
The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.
Ram H Nagaraj; Mikhail Linetsky; Alan W Stitt
The pathogenic role of Maillard reaction in the aging eye.

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All Publications

2013: Rooban B Nahomi; Cibin T Raghavan; Puttur Santhoshkumar; Oliver H Voss; Benlian Wang; Andrea I Doseff; Ram H Nagaraj
Chaperone Peptides of α-Crystallin Inhibit Epithelial Cell Apoptosis, Protein Insolubilization, and Opacification in Experimental Cataracts.
The Journal of biological chemistry 2013;288(18):13022-35.
2013: Rooban B Nahomi; Tomoko Oya-Ito; Ram H Nagaraj
The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.
Biochimica et biophysica acta 2013;1832(1):195-203.
2012: Ram H Nagaraj; Mikhail Linetsky; Alan W Stitt
The pathogenic role of Maillard reaction in the aging eye.
Amino acids 2012;42(4):1205-20.
2012: Ram H Nagaraj; Alok Kumar Panda; NagaRekha Pasupuleti; Puttur Santhoshkumar; Shilpa Shanthakumar; Benlian Wang; Ashis Biswas
Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics.
PloS one 2012;7(1):e30257.
2011: Mikhail Linetsky; Jasmin Meltretter; S R Kaid Johar; Smitha Padmanabha; Trilok Parmar; Monika Pischetsrieder; Abhay R Vasavada; Ram H Nagaraj
Determination of dideoxyosone precursors of AGEs in human lens proteins.
Archives of biochemistry and biophysics 2011;514(1-2):16-26.
2010: Maneesh Mailankot; Ram H Nagaraj
Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine.
The international journal of biochemistry & cell biology 2010;42(9):1446-54.
2010: Maneesh Mailankot; Scott Howell; Ram H Nagaraj
Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.
Biochimica et biophysica acta 2010;1802(7-8):609-20.
2010: Nagarekha Pasupuleti; Mahesha Gangadhariah; Smitha Padmanabha; Puttur Santhoshkumar; Ram H Nagaraj
The role of the cysteine residue in the chaperone and anti-apoptotic functions of human Hsp27.
Journal of cellular biochemistry 2010;110(2):408-19.
2010: Mahesha H Gangadhariah; Benlian Wang; Mikhail Linetsky; Christian Henning; Robert Spanneberg; MA Glomb; Ram H Nagaraj
Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.
Biochimica et biophysica acta 2010;1802(4):432-41.
2010: Ram H Nagaraj; Smitha Padmanabha; Maneesh Mailankot; Magdalena Staniszewska; Liew Jun Mun; MA Glomb; Mikhail D Linetsky
Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins.
Biochimica et biophysica acta 2010;1804(4):829-38.
2010: N Pasupuleti; S Matsuyama; O Voss; A I Doseff; K Song; D Danielpour; Ram H Nagaraj
The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity.
Cell death & disease 2010;1():e31.
2010: Mahesha Gangadhariah; Maneesh Mailankot; Lixing W Reneker; Ram H Nagaraj
Inhibition of methylglyoxal-mediated protein modification in glyoxalase I overexpressing mouse lenses.
Journal of ophthalmology 2010;2010():274317.
2010: David J Bonda; Maneesh Mailankot; Jeremy G Stone; Matthew R Garrett; Magdalena Staniszewska; Rudy J Castellani; Sandra L Siedlak; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Ram H Nagaraj; Mark A. Smith
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.
Redox report : communications in free radical research 2010;15(4):161-8.
2009: Maneesh Mailankot; Smitha Padmanabha; NagaRekha Pasupuleti; Denice Major; Scott Howell; Ram H Nagaraj
Glyoxalase I activity and immunoreactivity in the aging human lens.
Biogerontology 2009;10(6):711-20.
2009: Maneesh Mailankot; Magdalena Staniszewska; Heather Butler; Moonkyung H Caprara; Scott Howell; Benlian Wang; Catherine Doller; Lixing W Reneker; Ram H Nagaraj
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens.
Laboratory investigation; a journal of technical methods and pathology 2009;89(5):498-512.
2009: Santosh Kanade; NagaRekha Pasupuleti; Ram H Nagaraj
Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin.
Molecular and cellular biochemistry 2009;322(1-2):185-91.
2008: Maneesh Mailankot; Dawn Smith; Scott Howell; Benlian Wang; James W Jacobberger; Tammy Stefan; Ram H Nagaraj
Cell cycle arrest by kynurenine in lens epithelial cells.
Investigative ophthalmology & visual science 2008;49(12):5466-75.
2008: Zhi-jian Guo; Hong Xin Niu; Fan-fan Hou; Lu Zhang; Ning Fu; Ryoji Nagai; Xiao Lu; Bai Hong Chen; Yue Xin Shan; Jian Wei Tian; Ram H Nagaraj; Di Xie; Xun Zhang
Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway.
Antioxidants & redox signaling 2008;10(10):1699-712.
2008: Ashis Biswas; Shawn Lewis; Benlian Wang; Masaru Miyagi; Puttur Santoshkumar; Mahesha Gangadhariah; Ram H Nagaraj
Chemical modulation of the chaperone function of human alphaA-crystallin.
Journal of biochemistry 2008;144(1):21-32.
2008: Ram H Nagaraj; Ashis Biswas; Antonia Miller; Tomoko Oya-Ito; Manjunatha Bhat
The other side of the Maillard reaction.
Annals of the New York Academy of Sciences 2008;1126():107-12.
2008: Ashis Biswas; Benlian Wang; Masaru Miyagi; Ram H Nagaraj
Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alphaA-crystallin.
The Biochemical journal 2008;409(3):771-7.
2007: Magdalena Staniszewska; Ram H Nagaraj
Detection of kynurenine modifications in proteins using a monoclonal antibody.
Journal of immunological methods 2007;324(1-2):63-73.
2007: Shivaprakash Puttaiah; Ashis Biswas; Magdalena Staniszewska; Ram H Nagaraj
Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin.
Experimental eye research 2007;84(5):914-21.
2007: Ashis Biswas; Jeffery Goshe; Antonia Miller; Puttur Santhoshkumar; Carol Luckey; Manjunatha B Bhat; Ram H Nagaraj
Paradoxical effects of substitution and deletion mutation of Arg56 on the structure and chaperone function of human alphaB-crystallin.
Biochemistry 2007;46(5):1117-27.
2006: Tomoko Oya-Ito; Bing-Fen Liu; Ram H Nagaraj
Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27.
Journal of cellular biochemistry 2006;99(1):279-91.
2006: Magdalena Staniszewska; Ram H Nagaraj
Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses.
Molecular and cellular biochemistry 2006;288(1-2):29-36.
2006: Antonia G Miller; Dawn G Smith; Manjunatha Bhat; Ram H Nagaraj
Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions.
The Journal of biological chemistry 2006;281(17):11864-71.
2006: Ashis Biswas; Antonia Miller; Tomoko Oya-Ito; Puttur Santhoshkumar; Manjunatha Bhat; Ram H Nagaraj
Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin.
Biochemistry 2006;45(14):4569-77.
2006: Shivaprakash Puttaiah; Yuming Zhang; Heather A Pilch; Christoph Pfahler; Tomoko Oya-Ito; Lawrence M Sayre; Ram H Nagaraj
Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures.
Archives of biochemistry and biophysics 2006;446(2):186-96.
2006: Simi Padival; Ram H Nagaraj
Pyridoxamine inhibits maillard reactions in diabetic rat lenses.
Ophthalmic research 2006;38(5):294-302.
2005: Magdalena Staniszewska; Ram H Nagaraj
3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.
The Journal of biological chemistry 2005;280(23):22154-64.
2005: Ram H Nagaraj; Tomoko Oya-Ito; Manjunatha Bhat; Bingfen Liu
Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.
Annals of the New York Academy of Sciences 2005;1043():158-65.
2004: Bingfen Liu; Manjunatha Bhat; Ram H Nagaraj
AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells.
Biochemical and biophysical research communications 2004;321(1):254-8.
2004: Bingfen Liu; Manjunatha Bhat; Anoop K Padival; Dawn G Smith; Ram H Nagaraj
Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes.
Investigative ophthalmology & visual science 2004;45(6):1983-95.
2003: Ram H Nagaraj; Tomoko Oya-Ito; Pius S Padayatti; Radhika Kumar; Sachin Mehta; Karen West; Bruce Levison; Jian Sun; John W Crabb; Anoop K Padival
Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification.
Biochemistry 2003;42(36):10746-55.
2003: Anoop K Padival; John W Crabb; Ram H Nagaraj
Methylglyoxal modifies heat shock protein 27 in glomerular mesangial cells.
FEBS letters 2003;551(1-3):113-8.
2003: Ralf Dahm; Silvia Bramke; Jens Dawczynski; Ram H Nagaraj; Michael Kasper
Developmental aspects of galectin-3 expression in the lens.
Histochemistry and cell biology 2003;119(3):219-26.
2002: Line Kessel; Stanislav Kalinin; Ram H Nagaraj; Michael Larsen; Lennart B-A Johansson
Time-resolved and steady-state fluorescence spectroscopic studies of the human lens with comparison to argpyrimidine, pentosidine and 3-OH-kynurenine.
Photochemistry and photobiology 2002;76(5):549-54.
2002: Kenneth C Mathys; Stephen N Ponnampalam; Simi Padival; Ram H Nagaraj
Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes.
Biochemical and biophysical research communications 2002;297(4):863-9.
2002: S Swamy-Mruthinti; K Coral Miriam; S Krishna Kumar; Jyotirmay Biswas; S Ramakrishnan; Ram H Nagaraj; Konerirajapuram N Sulochana
Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.
Current eye research 2002;25(3):139-45.
2002: Ram H Nagaraj; Pratishruti Sarkar; Anirudh Mally; Klaus M Biemel; Markus O Lederer; Pius S Padayatti
Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal.
Archives of biochemistry and biophysics 2002;402(1):110-9.
2001: Pius S Padayatti; C Jiang; MA Glomb; K Uchida; Ram H Nagaraj
High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells.
Current eye research 2001;23(2):106-15.
2001: Pius S Padayatti; A S Ng; K Uchida; MA Glomb; Ram H Nagaraj
Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses.
Investigative ophthalmology & visual science 2001;42(6):1299-304.
2001: SHAWN WILKER; P Chellan; B M Arnold; Ram H Nagaraj
Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine.
Analytical biochemistry 2001;290(2):353-8.
2001: P Chellan; Ram H Nagaraj
Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation.
The Journal of biological chemistry 2001;276(6):3895-903.
2001: MA Glomb; Daniel Rösch; Ram H Nagaraj
N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer.
Journal of agricultural and food chemistry 2001;49(1):366-72.
2000: Timothy S Kern; Jie Tang; M Mizutani; Renu A Kowluru; Ram H Nagaraj; G Romeo; F Podesta; M Lorenzi
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia.
Investigative ophthalmology & visual science 2000;41(12):3972-8.
2000: C Sady; C L Jiang; P Chellan; ZT Madhun; Y Duve; MA Glomb; Ram H Nagaraj
Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins.
Biochimica et biophysica acta 2000;1481(2):255-64.
2000: FA Shamsi; E Sharkey; D Creighton; Ram H Nagaraj
Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens.
Experimental eye research 2000;70(3):369-80.
1999: FA Shamsi; Ram H Nagaraj
Immunochemical detection of dicarbonyl-derived imidazolium protein crosslinks in human lenses.
Current eye research 1999;19(3):276-84.
1999: P Chellan; Ram H Nagaraj
Protein crosslinking by the Maillard reaction: dicarbonyl-derived imidazolium crosslinks in aging and diabetes.
Archives of biochemistry and biophysics 1999;368(1):98-104.
1999: Ram H Nagaraj; FA Shamsi; B Huber; Monika Pischetsrieder
Immunochemical detection of oxalate monoalkylamide, an ascorbate-derived Maillard reaction product in the human lens.
FEBS letters 1999;453(3):327-30.
1998: FA Shamsi; K Lin; C Sady; Ram H Nagaraj
Methylglyoxal-derived modifications in lens aging and cataract formation.
Investigative ophthalmology & visual science 1998;39(12):2355-64.
1998: FA Shamsi; A Partal; C Sady; MA Glomb; Ram H Nagaraj
Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.
The Journal of biological chemistry 1998;273(12):6928-36.
1997: Mark A. Smith; Ram H Nagaraj; George Perry
Protocol for quantitative analysis of paired helical filament solubilization: a method applicable to insoluble amyloids and inclusion bodies.
Brain research. Brain research protocols 1997;1(3):247-52.
1997: I N Shipanova; MA Glomb; Ram H Nagaraj
Protein modification by methylglyoxal: chemical nature and synthetic mechanism of a major fluorescent adduct.
Archives of biochemistry and biophysics 1997;344(1):29-36.
1996: Ram H Nagaraj; I N Shipanova; F M Faust
Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal.
The Journal of biological chemistry 1996;271(32):19338-45.
1996: Ram H Nagaraj; T S Kern; David R Sell; J Fogarty; RL Engerman; Vincent M Monnier
Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen.
Diabetes 1996;45(5):587-94.
1996: Mark A. Smith; Sandra L Siedlak; P L Richey; Ram H Nagaraj; A Elhammer; George Perry
Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
Brain research 1996;717(1-2):99-108.
1996: Ram H Nagaraj; C Sady
The presence of a glucose-derived Maillard reaction product in the human lens.
FEBS letters 1996;382(3):234-8.
1996: Ram H Nagaraj; Manuel Portero-Otin; Vincent M Monnier
Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes.
Archives of biochemistry and biophysics 1996;325(2):152-8.
1996: Vincent M Monnier; Ram H Nagaraj; Manuel Portero-Otin; MA Glomb; A H Elgawish; David R Sell; MA Friedlander
Structure of advanced Maillard reaction products and their pathological role.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 5():20-6.
1995: Ram H Nagaraj; Vincent M Monnier
Protein modification by the degradation products of ascorbate: formation of a novel pyrrole from the Maillard reaction of L-threose with proteins.
Biochimica et biophysica acta 1995;1253(1):75-84.
1995: C Sady; S Khosrof; Ram H Nagaraj
Advanced Maillard reaction and crosslinking of corneal collagen in diabetes.
Biochemical and biophysical research communications 1995;214(3):793-7.
1995: Manuel Portero-Otin; Ram H Nagaraj; Vincent M Monnier
Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo.
Biochimica et biophysica acta 1995;1247(1):74-80.
1994: Ram H Nagaraj; M Prabhakaram; Beryl J Ortwerth; Vincent M Monnier
Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase.
Diabetes 1994;43(4):580-6.
1994: Vincent M Monnier; David R Sell; Ram H Nagaraj
[The role of glucose in the pathogenesis of diabetes complications].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1994;():61-70.
1993: Vincent M Monnier; S Miyata; Ram H Nagaraj; David R Sell
Relevance of the early and advanced Maillard reaction in diabetic neuropathy.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():103S-106S.
1992: Vincent M Monnier; David R Sell; Ram H Nagaraj; S Miyata; S Grandhee; P Odetti; S A Ibrahim
Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia.
Diabetes 1992;41 Suppl 2():36-41.
1992: Ram H Nagaraj; Vincent M Monnier
Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose.
Biochimica et biophysica acta 1992;1116(1):34-42.
1991: David R Sell; Ram H Nagaraj; S K Grandhee; P Odetti; A Lapolla; J Fogarty; Vincent M Monnier
Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia.
Diabetes/metabolism reviews 1991;7(4):239-51.
1991: Ram H Nagaraj; David R Sell; M Prabhakaram; Beryl J Ortwerth; Vincent M Monnier
High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10257-61.
1991: Vincent M Monnier; David R Sell; Ram H Nagaraj; S Miyata
Mechanisms of protection against damage mediated by the Maillard reaction in aging.
Gerontology 1991;37(1-3):152-65.
1990: Ram H Nagaraj; Vincent M Monnier
Non-tryptophan fluorescence and high molecular weight protein formation in lens crystallins of rats with chronic galactosemia: prevention by the aldose reductase inhibitor sorbinil.
Experimental eye research 1990;51(4):411-8.
1989: F Hayase; Ram H Nagaraj; S Miyata; F G Njoroge; Vincent M Monnier
Aging of proteins: immunological detection of a glucose-derived pyrrole formed during maillard reaction in vivo.
The Journal of biological chemistry 1989;264(7):3758-64.