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Yukio Nagasaki

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Thangavel Lakshmipriya; Koichi Awazu; Makoto Fujimaki; Subash C B Gopinath; Yukichi Horiguchi; Yukio Nagasaki
A high-performance waveguide-mode biosensor for detection of factor IX using PEG-based blocking agents to suppress non-specific binding and improve sensitivity.
Babita Shashni; Yukio Nagasaki; Kishore Sakharkar; Meena Kishore Sakharkar
Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology.
Md Amran Hossain; Yutaka Ikeda; Toru Hara; Yukio Nagasaki
Novel biocompatible nanoreactor for silica/gold hybrid nanoparticles preparation.

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2013: Thangavel Lakshmipriya; Koichi Awazu; Makoto Fujimaki; Subash C B Gopinath; Yukichi Horiguchi; Yukio Nagasaki
A high-performance waveguide-mode biosensor for detection of factor IX using PEG-based blocking agents to suppress non-specific binding and improve sensitivity.
The Analyst 2013;138(10):2863-70.
2013: Babita Shashni; Yukio Nagasaki; Kishore Sakharkar; Meena Kishore Sakharkar
Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology.
Journal of drug targeting 2013;21(2):161-74.
2013: Md Amran Hossain; Yutaka Ikeda; Toru Hara; Yukio Nagasaki
Novel biocompatible nanoreactor for silica/gold hybrid nanoparticles preparation.
Colloids and surfaces. B, Biointerfaces 2013;102():778-82.
2012: Toru Yoshitomi; Yukio Nagasaki
Design and preparation of a nanoprobe for imaging inflammation sites.
Biointerphases 2012;7(1-4):7.
2012: Xiaofei Yuan; Keitaro Yoshimoto; Dolça Fabregat; Yukio Nagasaki
Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism.
Colloids and surfaces. B, Biointerfaces 2012;99():45-52.
2012: Long Binh Vong; Toru Yoshitomi; Hirofumi Matsui; Tsutomu Tomita; Yukio Nagasaki
An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice.
Gastroenterology 2012;143(4):1027-36.e3.
2012: Shunsuke Tomita; Yukio Nagasaki; Kentaro Shiraki
Different mechanisms of action of poly(ethylene glycol) and arginine on thermal inactivation of lysozyme and ribonuclease A.
Biotechnology and bioengineering 2012;109(10):2543-52.
2012: Yutaka Ikeda; Takeshi Ikeya; Tomoko Jomura; Junko Saeki; Keitaro Yoshimoto; Umeko Horiuchi; Yukio Nagasaki
Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array.
Colloids and surfaces. B, Biointerfaces 2012;97():97-100.
2012: Pennapa Chonpathompikunlert; Ching-Hsiang Fan; Yuki Ozaki; Chih-Kuang Yeh; Toru Yoshitomi; Yukio Nagasaki
Redox nanoparticle treatment protects against neurological deficit in focused ultrasound-induced intracerebral hemorrhage.
Nanomedicine (London, England) 2012;7(7):1029-43.
2012: Masao Kamimura; JONG OH KIM; Tatiana K Bronich; Alexander V Kabanov; Yukio Nagasaki
Block ionomer complexes of PEG-block-poly(4-vinylbenzylphosphonate) and cationic surfactants as highly stable, pH responsive drug delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(3):486-94.
2012: Shogo Sumitani; Minoru Suzuki; Tatsuya Yaguchi; Hironobu Yanagie; Yukichi Horiguchi; Hiroki Murotani; Motoi Oishi; Koji Ono; Yukio Nagasaki
Pharmacokinetics of core-polymerized, boron-conjugated micelles designed for boron neutron capture therapy for cancer.
Biomaterials 2012;33(13):3568-77.
2012: Xiaofei Yuan; Keitaro Yoshimoto; Dolça Fabregat; Yukio Nagasaki
High PEGylation efficiency of pentaethylenehexamine-end poly(ethylene glycol) (mPEG-N6) for active-ester surface.
Colloids and surfaces. B, Biointerfaces 2012;92():25-9.
2012: Takaaki Kurinomaru; Yukio Nagasaki; Sumon Ganguli; Shinpei Kudo; Shunsuke Tomita; Kentaro Shiraki
Improved complementary polymer pair system: switching for enzyme activity by PEGylated polymers.
Langmuir : the ACS journal of surfaces and colloids 2012;28(9):4334-8.
2012: Toru Yoshitomi; Yu Yamaguchi; Akihiko Kikuchi; Yukio Nagasaki
Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity.
Acta biomaterialia 2012;8(3):1323-9.
2012: Yukio Nagasaki
Nitroxide radicals and nanoparticles: a partnership for nanomedicine radical delivery.
Therapeutic delivery 2012;3(2):165-79.
2011: Kodai Ujiie; Keiichi Yamada; Masayuki Yamaguchi; Hideto Yanagihara; Tatsuya Oda; Yusuke Ohara; Nobuhiro Ohkohchi; Yoshimasa Akashi; Kei Asai; Hirofumi Fujii; Shinji Hashimoto; Naoki Kanayama; Mikio Kishimoto; Eiji Kita; Yukio Nagasaki
Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles Multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly.
Colloids and surfaces. B, Biointerfaces 2011;88(2):771-8.
2011: Pennapa Chonpathompikunlert; Junkyu Han; Hiroko Isoda; Toru Yoshitomi; Yukio Nagasaki
The use of nitroxide radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress.
Biomaterials 2011;32(33):8605-12.
2011: Toru Yoshitomi; Aki Hirayama; Yukio Nagasaki
The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles.
Biomaterials 2011;32(31):8021-8.
2011: Masao Kamimura; Naoki Kanayama; Kohei Soga; Kimikazu Tokuzen; Yukio Nagasaki
Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate).
Nanoscale 2011;3(9):3705-13.
2011: Pennapa Chonpathompikunlert; Junkyu Han; Hiroko Isoda; Kazuko Toh; Toru Yoshitomi; Yukio Nagasaki
Chemical nanotherapy: nitroxyl radical-containing nanoparticle protects neuroblastoma SH-SY5Y cells from Abeta-induced oxidative stress.
Therapeutic delivery 2011;2(5):585-97.
2011: Toru Yoshitomi; Yukio Nagasaki
Nitroxyl radical-containing nanoparticles for novel nanomedicine against oxidative stress injury.
Nanomedicine (London, England) 2011;6(3):509-18.
2011: Yutaka Ikeda; Rie Suzuki; Toru Yoshitomi; Yukio Nagasaki
Novel oligonucleotide carrier as scavenger for reactive oxygen species.
Macromolecular bioscience 2011;11(3):344-51.
2011: Pennapa Chonpathompikunlert; Junkyu Han; Kazuko Toh; Hiroko Isoda; Yukio Nagasaki
TEMPOL protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell toxicity.
European journal of pharmacology 2011;650(2-3):544-9.
2010: Atsushi Tamura; Motoi Oishi; Yukio Nagasaki
Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(3):378-87.
2010: Atsushi Tamura; Yukio Nagasaki
Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles.
Nanomedicine (London, England) 2010;5(7):1089-102.
2010: Sumon Ganguli; Keitaro Yoshimoto; Shunsuke Tomita; Hiroshi Sakuma; Tsuneyoshi Matsuoka; Kentaro Shiraki; Yukio Nagasaki
Improving the heat resistance of ribonuclease A by the addition of poly(N,N-diethylaminoethyl methacrylate)-graft-poly(ethylene glycol) (PEAMA-g-PEG).
Macromolecular bioscience 2010;10(8):853-9.
2010: Keitaro Yoshimoto; Motohiko Nishio; Hiroaki Sugasawa; Yukio Nagasaki
Direct observation of adsorption-induced inactivation of antibody fragments surrounded by mixed-PEG layer on a gold surface.
Journal of the American Chemical Society 2010;132(23):7982-9.
2010: Takahito Nakamura; Atsushi Tamura; Hiroki Murotani; Motoi Oishi; Yuta Jinji; Kiyoto Matsuishi; Yukio Nagasaki
Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy.
Nanoscale 2010;2(5):739-46.
2009: Keitaro Yoshimoto; Takumi Hirase; Jeppe Madsen; Steven P Armes; Yukio Nagasaki
Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the 'Grafting to' Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces.
Macromolecular rapid communications 2009;30(24):2136-40.
2009: Xiaofei Yuan; Dolça Fabregat; Keitaro Yoshimoto; Yukio Nagasaki
Efficient inhibition of interfacial nonspecific interaction to create practically utilizable high ferritin-response immunolatex.
Analytical chemistry 2009;81(24):10097-105.
2009: Atsushi Tamura; Motoi Oishi; Yukio Nagasaki
Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure.
Biomacromolecules 2009;10(7):1818-27.
2009: Toru Yoshitomi; Daisuke Miyamoto; Yukio Nagasaki
Design of core--shell-type nanoparticles carrying stable radicals in the core.
Biomacromolecules 2009;10(3):596-601.
2007: Motoi Oishi; Yukio Nagasaki; Nobuhiro Nishiyama; Keiji Itaka; Motoki Takagi; Akira Shimamoto; Yasuhiro Furuichi; Kazunori Kataoka
Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes.
ChemMedChem 2007;2(9):1290-7.
2007: Seiji Takae; Yoshitsugu Akiyama; Yuichi Yamasaki; Yukio Nagasaki; Kazunori Kataoka
Colloidal Au replacement assay for highly sensitive quantification of low molecular weight analytes by surface plasmon resonance.
Bioconjugate chemistry 2007;18(4):1241-5.
2007: Yukio Nagasaki; Hiroshi Kobayashi; Yoshinori Katsuyama; Tomoko Jomura; Takeshi Sakura
Enhanced immunoresponse of antibody/mixed-PEG co-immobilized surface construction of high-performance immunomagnetic ELISA system.
Journal of colloid and interface science 2007;309(2):524-30.
2007: Keitaro Yoshimoto; Hiroshi Atsumi; Shingo Saito; Moriya Okuma; Mizuo Maeda; Yukio Nagasaki
Fluorescence-based affinity labeling of nucleobase by hydrogen-bond forming metal complex.
Nucleic acids symposium series (2004) 2007;(51):303-4.
2006: Md Monsur Ali; Motoi Oishi; Fumi Nagatsugi; Kenya Mori; Yukio Nagasaki; Kazunori Kataoka; Shigeki Sasaki
Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide.
Angewandte Chemie (International ed. in English) 2006;45(19):3136-40.
2006: Motoi Oishi; Kazunori Kataoka; Yukio Nagasaki
pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector.
Bioconjugate chemistry 2006;17(3):677-88.
2005: Motoi Oishi; Tetsuya Hayama; Yoshitsugu Akiyama; Seiji Takae; Atsushi Harada; Yuichi Yamasaki; Fumi Nagatsugi; Shigeki Sasaki; Yukio Nagasaki; Kazunori Kataoka
Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate.
Biomacromolecules 2005;6(5):2449-54.
2005: Motoi Oishi; Fumi Nagatsugi; Shigeki Sasaki; Yukio Nagasaki; Kazunori Kataoka
Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages.
Chembiochem : a European journal of chemical biology 2005;6(4):718-25.
2005: Seiji Takae; Yoshitsugu Akiyama; Hidenori Otsuka; Teisaku Nakamura; Yukio Nagasaki; Kazunori Kataoka
Ligand density effect on biorecognition by PEGylated gold nanoparticles: regulated interaction of RCA120 lectin with lactose installed to the distal end of tethered PEG strands on gold surface.
Biomacromolecules 2005;6(2):818-24.
2005: Motoi Oishi; Yukio Nagasaki; Keiji Itaka; Nobuhiro Nishiyama; Kazunori Kataoka
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.
Journal of the American Chemical Society 2005;127(6):1624-5.
2005: Kazunori Kataoka; Keiji Itaka; Nobuhiro Nishiyama; Yuichi Yamasaki; Motoi Oishi; Yukio Nagasaki
Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery.
Nucleic acids symposium series (2004) 2005;(49):17-8.
2004: Hidenori Otsuka; Yukio Nagasaki; Kazunori Kataoka
Characterization of aldehyde-PEG tethered surfaces: influence of PEG chain length on the specific biorecognition.
Langmuir : the ACS journal of surfaces and colloids 2004;20(26):11285-7.
2004: Daisuke Wakebayashi; Nobuhiro Nishiyama; Keiji Itaka; Kanjiro Miyata; Yuichi Yamasaki; Atsushi Harada; Hiroyuki Koyama; Yukio Nagasaki; Kazunori Kataoka
Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy.
Biomacromolecules 2004;5(6):2128-36.
2004: Eduardo Jule; Yuji Yamamoto; Muriel Thouvenin; Yukio Nagasaki; Kazunori Kataoka
Thermal characterization of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles based on pyrene excimer formation.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(3):407-19.
2004: Hidenori Otsuka; Akihiro Hirano; Yukio Nagasaki; Teruo Okano; Yasuhiro Horiike; Kazunori Kataoka
Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface.
Chembiochem : a European journal of chemical biology 2004;5(6):850-5.
2004: Daisuke Wakebayashi; Nobuhiro Nishiyama; Yuichi Yamasaki; Keiji Itaka; Naoki Kanayama; Atsushi Harada; Yukio Nagasaki; Kazunori Kataoka
Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):653-64.
2004: Yoshitsugu Akiyama; Yukio Nagasaki; Kazunori Kataoka
Synthesis of heterotelechelic poly(ethylene glycol) derivatives having alpha-benzaldehyde and omega-pyridyl disulfide groups by ring opening polymerization of ethylene oxide using 4-(diethoxymethyl)benzyl alkoxide as a novel initiator.
Bioconjugate chemistry 2004;15(2):424-7.
2004: Ali Md Monsur; Fumi Nagatsugi; Motoi Oishi; Yukio Nagasaki; Kazunari Kataoka; Shigeki Sasaki
Synthesis and evaluation of the functional oligonucleotides-PEG conjugates.
Nucleic acids symposium series (2004) 2004;(48):61-2.
2003: Motoi Oishi; Shigeki Sasaki; Yukio Nagasaki; Kazunori Kataoka
pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation.
Biomacromolecules 2003;4(5):1426-32.
2003: Eduardo Jule; Yukio Nagasaki; Kazunori Kataoka
Lactose-installed poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study.
Bioconjugate chemistry 2003;14(1):177-86.
2002: Yuji Yamamoto; Kenji Yasugi; Atsushi Harada; Yukio Nagasaki; Kazunori Kataoka
Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles in aqueous milieu.
Journal of controlled release : official journal of the Controlled Release Society 2002;82(2-3):359-71.
2001: Yuji Yamamoto; Yukio Nagasaki; Yukio Kato; Yuichi Sugiyama; Kazunori Kataoka
Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(1-2):27-38.
2001: Hidenori Otsuka; Y Akiyama; Yukio Nagasaki; Kazunori Kataoka
Quantitative and reversible lectin-induced association of gold nanoparticles modified with alpha-lactosyl-omega-mercapto-poly(ethylene glycol).
Journal of the American Chemical Society 2001;123(34):8226-30.
2001: Kazunori Kataoka; Atsushi Harada; Yukio Nagasaki
Block copolymer micelles for drug delivery: design, characterization and biological significance.
Advanced drug delivery reviews 2001;47(1):113-31.
2001: Yukio Nagasaki; Kenji Yasugi; Yuji Yamamoto; Atsushi Harada; Kazunori Kataoka
Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules.
Biomacromolecules 2001;2(4):1067-70.
2000: Hidenori Otsuka; Yukio Nagasaki; Kazunori Kataoka
Surface characterization of functionalized polylactide through the coating with heterobifunctional poly(ethylene glycol)/polylactide block copolymers.
Biomacromolecules 2000;1(1):39-48.
1999: Kenji Yasugi; Yukio Nagasaki; M Kato; Kazunori Kataoka
Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):89-100.
1998: Tetsuya Nakamura; Yukio Nagasaki; Kazunori Kataoka
Synthesis of heterobifunctional poly(ethylene glycol) with a reducing monosaccharide residue at one end.
Bioconjugate chemistry 1998;9(2):300-3.