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Hideaki Nagase

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Physiology

Enzyme Activation

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Elisa Nuti; Elisabetta Orlandini; Silvia Salerno; Salvatore Santamaria; Sabrina Taliani; Kazuhiro Yamamoto; Francesca Casalini; Federico Da Settimo; Valeria La Pietra; Luciana Marinelli; Anna Maria Marini; Hideaki Nagase; Susanna Nencetti; Ettore Novellino; Armando Rossello
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Kazuhiro Yamamoto; Christopher L Murphy; Michele Pelosi; Simone D Scilabra; Dudley K Strickland; Linda Troeberg; Hideaki Nagase
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
Simone D Scilabra; Dudley K Strickland; Ida Thøgersen; Linda Troeberg; Kazuhiro Yamamoto; Hervé EMONARD; Jan J Enghild; Hideaki Nagase
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.

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All Publications

2013: Elisa Nuti; Elisabetta Orlandini; Silvia Salerno; Salvatore Santamaria; Sabrina Taliani; Kazuhiro Yamamoto; Francesca Casalini; Federico Da Settimo; Valeria La Pietra; Luciana Marinelli; Anna Maria Marini; Hideaki Nagase; Susanna Nencetti; Ettore Novellino; Armando Rossello
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
European journal of medicinal chemistry 2013;62():379-94.
2013: Kazuhiro Yamamoto; Christopher L Murphy; Michele Pelosi; Simone D Scilabra; Dudley K Strickland; Linda Troeberg; Hideaki Nagase
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(2):511-21.
2013: Simone D Scilabra; Dudley K Strickland; Ida Thøgersen; Linda Troeberg; Kazuhiro Yamamoto; Hervé EMONARD; Jan J Enghild; Hideaki Nagase
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
The Journal of biological chemistry 2013;288(1):332-42.
2012: Szymon W Manka; Gillian Murphy; Nicolas Raynal; Robert Visse; Dominique Bihan; Federico Carafoli; Jan J Enghild; Richard W Farndale; Erhard Hohenester; Hideaki Nagase
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12461-6.
2012: Zhuoxin Yu; Masayori Inouye; Hideaki Nagase; Robert Visse; Barbara Brodsky
Defining requirements for collagenase cleavage in collagen type III using a bacterial collagen system.
The Journal of biological chemistry 2012;287(27):22988-97.
2012: Alessandra Lo Cicero; Iwona Majkowska; Hideaki Nagase; Italia Di Liegro; Linda Troeberg
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Matrix biology : journal of the International Society for Matrix Biology 2012;31(4):229-33.
2012: Linda Troeberg; Peter Ghosh; Meng-Huee Lee; Barbara Mulloy; Gillian Murphy; Hideaki Nagase
Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
The Biochemical journal 2012;443(1):307-15.
2012: Valeria La Pietra; Concettina La Motta; Luciana Marinelli; Matteo Morelli; Hideaki Nagase; Francesca Casalini; Sandro Cosconati; Federico Da Settimo; Francesco Saverio Di Leva; Elisa Nuti; Isabella Pugliesi; Armando Rossello; Salvatore Santamaria; Sabrina Taliani; Robert Visse; Ettore Novellino
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
European journal of medicinal chemistry 2012;47(1):143-52.
2012: Linda Troeberg; Hideaki Nagase
Proteases involved in cartilage matrix degradation in osteoarthritis.
Biochimica et biophysica acta 2012;1824(1):133-45.
2011: Yoshifumi Itoh; Atsushi Miyawaki; Hideaki Nagase; Ralf Palmisano; Narayanapanicker Anilkumar; Motoharu Seiki
Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.
The Biochemical journal 2011;440(3):319-26.
2011: Anna Tochowicz; Peter Goettig; Richard Evans; Robert Visse; Yasuyuki Shitomi; Ralf Palmisano; Noriko Ito; Klaus Richter; Klaus Maskos; Daniel Franke; Dmitri I Svergun; Hideaki Nagase; Wolfram Bode; Yoshifumi Itoh
The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.
The Journal of biological chemistry 2011;286(9):7587-600.
2011: Hideaki Nagase; Nikos Karamanos
Metalloproteinases in health and disease: challenges and the future prospects.
The FEBS journal 2011;278(1):1.
2010: Ngee H Lim; Masahide Kashiwagi; Robert Visse; Jonathan Jones; Jan J Enghild; Keith Brew; Hideaki Nagase
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
The Biochemical journal 2010;431(1):113-22.
2010: Marie Kveiborg; Jonas Jacobsen; Meng-Huee Lee; Hideaki Nagase; Ulla M Wewer; Gillian Murphy
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
The Biochemical journal 2010;430(1):79-86.
2010: Sejin Han; Elena Makareeva; Natalia V Kuznetsova; Angela M DeRidder; Mary Beth Sutter; Wolfgang Losert; Charlotte L Phillips; Robert Visse; Hideaki Nagase; Sergey Leikin
Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.
The Journal of biological chemistry 2010;285(29):22276-81.
2010: Elena Makareeva; Sejin Han; Juan Carlos Vera; Dan L Sackett; Kenn Holmbeck; Charlotte L Phillips; Robert Visse; Hideaki Nagase; Sergey Leikin
Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.
Cancer research 2010;70(11):4366-74.
2010: Keith Brew; Hideaki Nagase
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
Biochimica et biophysica acta 2010;1803(1):55-71.
2009: Linda Troeberg; Kazunari Fushimi; Simone D Scilabra; Hiroyuki Nakamura; Vincent Dive; Ida B Thøgersen; Jan J Enghild; Hideaki Nagase
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(8):463-9.
2009: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Giovanni Cercignani; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; Elisabetta Orlandini; Susanna Nencetti; Tiziano Tuccinardi; Adriano Martinelli; Ngee-Han Lim; Robert Visse; Hideaki Nagase; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Journal of medicinal chemistry 2009;52(15):4757-73.
2009: Mary-Clare Miller; Hugh B Manning; Abhilash Jain; Linda Troeberg; Jayesh Dudhia; David Essex; Ann Sandison; Motoharu Seiki; Jagdeep Nanchahal; Hideaki Nagase; Yoshifumi Itoh
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis.
Arthritis and rheumatism 2009;60(3):686-97.
2008: Linda Troeberg; Kazunari Fushimi; Rama Khokha; Hervé EMONARD; Peter Ghosh; Hideaki Nagase
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3515-24.
2008: Yoshifumi Itoh; Noriko Ito; Hideaki Nagase; Motoharu Seiki
The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.
The Journal of biological chemistry 2008;283(19):13053-62.
2008: Kazunari Fushimi; Linda Troeberg; Hiroyuki Nakamura; Ngee Han Lim; Hideaki Nagase
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
The Journal of biological chemistry 2008;283(11):6706-16.
2008: Janelle L Lauer-Fields; Timothy P Spicer; Peter S Chase; Mare Cudic; Gayle D Burstein; Hideaki Nagase; Peter Hodder; Gregg Fields
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
Analytical biochemistry 2008;373(1):43-51.
2008: Jonas Jacobsen; Robert Visse; Hans Peter Sørensen; Jan J Enghild; Keith Brew; Ulla M Wewer; Hideaki Nagase
Catalytic properties of ADAM12 and its domain deletion mutants.
Biochemistry 2008;47(2):537-47.
2008: Hideaki Nagase; Kazunari Fushimi
Elucidating the function of non catalytic domains of collagenases and aggrecanases.
Connective tissue research 2008;49(3):169-74.
2007: Christi Gendron; Masahide Kashiwagi; Ngee Han Lim; Jan J Enghild; Ida B Thøgersen; Clare Hughes; Bruce Caterson; Hideaki Nagase
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
The Journal of biological chemistry 2007;282(25):18294-306.
2007: Janelle L Lauer-Fields; Dmitriy Minond; Thilaka Sritharan; Masahide Kashiwagi; Hideaki Nagase; Gregg Fields
Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.
The Journal of biological chemistry 2007;282(1):142-50.
2007: Linda Troeberg; Hideaki Nagase
Analysis of TIMP expression and activity.
Methods in molecular medicine 2007;135():251-67.
2006: Dmitriy Minond; Janelle L Lauer-Fields; Mare Cudic; Christopher M Overall; Duanqing Pei; Keith Brew; Robert Visse; Hideaki Nagase; Gregg Fields
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.
The Journal of biological chemistry 2006;281(50):38302-13.
2006: Yoshifumi Itoh; Noriko Ito; Hideaki Nagase; Richard D Evans; Sarah A Bird; Motoharu Seiki
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.
Molecular biology of the cell 2006;17(12):5390-9.
2006: Shalini Iyer; Robert Visse; Hideaki Nagase; K Ravi Acharya
Crystal structure of an active form of human MMP-1.
Journal of molecular biology 2006;362(1):78-88.
2006: Hideaki Nagase; Robert Visse; Gillian Murphy
Structure and function of matrix metalloproteinases and TIMPs.
Cardiovascular research 2006;69(3):562-73.
2005: Shuo Wei; Masahide Kashiwagi; Smitha Kota; Zhihong Xie; Hideaki Nagase; Keith Brew
Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
The Journal of biological chemistry 2005;280(38):32877-82.
2005: Narayanapanicker Anilkumar; Takamasa Uekita; John R Couchman; Hideaki Nagase; Motoharu Seiki; Yoshifumi Itoh
Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1326-8.
2005: Shan Bai; Ryan Thummel; Alan R Godwin; Hideaki Nagase; Yoshifumi Itoh; Li Li; Richard Evans; Jeff McDermott; Motoharu Seiki; Michael P Sarras
Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(4):247-60.
2005: Daniela Jozic; Gleb P Bourenkov; Ngee-Han Lim; Robert Visse; Hideaki Nagase; Wolfram Bode; Klaus Maskos
X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
The Journal of biological chemistry 2005;280(10):9578-85.
2004: Hervé EMONARD; Georges Bellon; Linda Troeberg; Alix Berton; Arnaud Robinet; Patrick Henriet; Etienne Marbaix; Kirstine Kirkegaard; László Patthy; Yves Eeckhout; Hideaki Nagase; William Hornebeck; Pierre J Courtoy
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
The Journal of biological chemistry 2004;279(52):54944-51.
2004: Janelle L Lauer-Fields; Hideaki Nagase; Gregg Fields
Development of a solid-phase assay for analysis of matrix metalloproteinase activity.
Journal of biomolecular techniques : JBT 2004;15(4):305-16.
2004: Linda Troeberg; Hideaki Nagase
Monitoring metalloproteinase activity using synthetic fluorogenic substrates.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 21():Unit 21.16.
2004: Linda Troeberg; Hideaki Nagase
Zymography of metalloproteinases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 21():Unit 21.15.
2004: Dmitriy Minond; Janelle L Lauer-Fields; Hideaki Nagase; Gregg Fields
Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability.
Biochemistry 2004;43(36):11474-81.
2004: Linda Chung; Deendayal Dinakarpandian; Naoto Yoshida; Janelle L Lauer-Fields; Gregg Fields; Robert Visse; Hideaki Nagase
Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.
The EMBO journal 2004;23(15):3020-30.
2004: Sabena Sultan; Martin Gosling; Hideaki Nagase; Janet T Powell
Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium.
FEBS letters 2004;564(1-2):161-5.
2004: Masahide Kashiwagi; Jan J Enghild; Christi Gendron; Clare Hughes; Bruce Caterson; Yoshifumi Itoh; Hideaki Nagase
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
The Journal of biological chemistry 2004;279(11):10109-19.
2004: Jeremy Saklatvala; Hideaki Nagase
Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004.
Arthritis research & therapy 2004;6(5):203-7.
2003: Christi Gendron; Masahide Kashiwagi; Clare Hughes; Bruce Caterson; Hideaki Nagase
TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.
FEBS letters 2003;555(3):431-6.
2003: Janelle L Lauer-Fields; Péter Kele; Guodong Sui; Hideaki Nagase; Roger M Leblanc; Gregg Fields
Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.
Analytical biochemistry 2003;321(1):105-15.
2003: Jinsong Zhang; Shan Bai; Xiaoming Zhang; Hideaki Nagase; Michael P Sarras
The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos.
Development genes and evolution 2003;213(9):456-63.
2003: Jinsong Zhang; Shan Bai; Carmen Tanase; Hideaki Nagase; Michael P Sarras
The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.
Development genes and evolution 2003;213(8):382-9.
2003: Janelle L Lauer-Fields; Thilaka Sritharan; M Sharon Stack; Hideaki Nagase; Gregg Fields
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.
The Journal of biological chemistry 2003;278(20):18140-5.
2003: Robert Visse; Hideaki Nagase
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
Circulation research 2003;92(8):827-39.
2003: Jinsong Zhang; Shan Bai; Xiaoming Zhang; Hideaki Nagase; Michael P Sarras
The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(3):279-93.
2003: Shuo Wei; Ying Chen; Linda Chung; Hideaki Nagase; Keith Brew
Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.
The Journal of biological chemistry 2003;278(11):9831-4.
2003: Hideaki Nagase; Keith Brew
Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
Biochemical Society symposium 2003;(70):201-12.
2003: Linda Troeberg; Hideaki Nagase
Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.
Methods in molecular biology (Clifton, N.J.) 2003;225():77-87.
2003: Hideaki Nagase; Masahide Kashiwagi
Aggrecanases and cartilage matrix degradation.
Arthritis research & therapy 2003;5(2):94-103.
2002: Linda Troeberg; Mitsuo Tanaka; Robin Wait; Yuenian Shi; Keith Brew; Hideaki Nagase
E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A).
Biochemistry 2002;41(50):15025-35.
2002: Hideaki Nagase; Keith Brew
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
Arthritis research 2002;4 Suppl 3():S51-61.
2001: Hideaki Nagase
Metalloproteases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 21():Unit 21.4.
2001: Janelle L Lauer-Fields; T Broder; Thilaka Sritharan; Linda Chung; Hideaki Nagase; Gregg Fields
Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates.
Biochemistry 2001;40(19):5795-803.
2001: M Kashiwagi; M Tortorella; Hideaki Nagase; Keith Brew
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
The Journal of biological chemistry 2001;276(16):12501-4.
2001: K Shimokawa; Hideaki Nagase
Purification of MMPs and TIMPs.
Methods in molecular biology (Clifton, N.J.) 2001;151():275-304.
2000: Linda Chung; K Shimokawa; Deendayal Dinakarpandian; F Grams; Gregg Fields; Hideaki Nagase
Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity.
The Journal of biological chemistry 2000;275(38):29610-7.
2000: Janelle L Lauer-Fields; K A Tuzinski; K i Shimokawa; Hideaki Nagase; Gregg Fields
Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.
The Journal of biological chemistry 2000;275(18):13282-90.
2000: Keith Brew; Deendayal Dinakarpandian; Hideaki Nagase
Tissue inhibitors of metalloproteinases: evolution, structure and function.
Biochimica et biophysica acta 2000;1477(1-2):267-83.
2000: J Ottl; D Gabriel; G Murphy; Vera Knäuper; Y Tominaga; Hideaki Nagase; M Kröger; Harald Tschesche; Wolfram Bode; Luis Moroder
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.
Chemistry & biology 2000;7(2):119-32.
1999: Hideaki Nagase; J Fred Woessner
Matrix metalloproteinases.
The Journal of biological chemistry 1999;274(31):21491-4.
1999: Wolfram Bode; Carlos Fernandez-Catalan; Frank Grams; FX Gomis-Rüth; Hideaki Nagase; Harald Tschesche; Klaus Maskos
Insights into MMP-TIMP interactions.
Annals of the New York Academy of Sciences 1999;878():73-91.
1999: Hideaki Nagase; Qing Meng; VA Malinovskii; Wei Huang; Linda Chung; Wolfram Bode; Klaus Maskos; Keith Brew
Engineering of selective TIMPs.
Annals of the New York Academy of Sciences 1999;878():1-11.
1999: Qing Meng; VA Malinovskii; Wei Huang; Y Hu; Linda Chung; Hideaki Nagase; Wolfram Bode; Klaus Maskos; Keith Brew
Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate.
The Journal of biological chemistry 1999;274(15):10184-9.
1999: Wolfram Bode; Carlos Fernandez-Catalan; Harald Tschesche; Frank Grams; Hideaki Nagase; Klaus Maskos
Structural properties of matrix metalloproteinases.
Cellular and molecular life sciences : CMLS 1999;55(4):639-52.
1999: Wolfram Bode; Carlos Fernandez-Catalan; Hideaki Nagase; Klaus Maskos
Endoproteinase-protein inhibitor interactions.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):3-10.
1998: Yoshifumi Itoh; Akira Ito; K Iwata; K Tanzawa; Y Mori; Hideaki Nagase
Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface.
The Journal of biological chemistry 1998;273(38):24360-7.
1998: Hideaki Nagase
Cell surface activation of progelatinase A (proMMP-2) and cell migration.
Cell research 1998;8(3):179-86.
1998: Kazushi Suzuki; CC Kan; Wesley Hung; MR Gehring; Keith Brew; Hideaki Nagase
Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1).
Biological chemistry 1998;379(2):185-91.
1997: J C Müller; E G von Roedern; Frank Grams; Hideaki Nagase; Luis Moroder
Non-peptidic cysteine derivatives as inhibitors of matrix metalloproteinases.
Biological chemistry 1997;378(12):1475-80.
1997: J D Mott; Raja Khalifah; Hideaki Nagase; Charles F Shield; J K Hudson; Billy G Hudson
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility.
Kidney international 1997;52(5):1302-12.
1997: FX Gomis-Rüth; Klaus Maskos; M Betz; Albrecht Bergner; Robert Huber; K Suzuki; N Yoshida; Hideaki Nagase; Keith Brew; Gleb P Bourenkov; Hans D Bartunik; Wolfram Bode
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature 1997;389(6646):77-81.
1997: Wei Huang; Qing Meng; Kazushi Suzuki; Hideaki Nagase; Keith Brew
Mutational study of the amino-terminal domain of human tissue inhibitor of metalloproteinases 1 (TIMP-1) locates an inhibitory region for matrix metalloproteinases.
The Journal of biological chemistry 1997;272(35):22086-91.
1997: Hideaki Nagase; Kazushi Suzuki; T E Cawston; Keith Brew
Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1).
The Biochemical journal 1997;325 ( Pt 1)():163-7.
1997: Hideaki Nagase
Activation mechanisms of matrix metalloproteinases.
Biological chemistry 1997;378(3-4):151-60.
1997: E Korzus; Hideaki Nagase; R Rydell; James Travis
The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression.
The Journal of biological chemistry 1997;272(2):1188-96.
1997: S K Das; S Yano; J Wang; D R Edwards; Hideaki Nagase; Sudhansu K Dey
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period.
Developmental genetics 1997;21(1):44-54.
1996: C A Rankin; Kazushi Suzuki; Yoshifumi Itoh; D M Ziemer; Jared J Grantham; James P Calvet; Hideaki Nagase
Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules.
Kidney international 1996;50(3):835-44.
1996: U Benbow; G Butticè; Hideaki Nagase; Markku T Kurkinen
Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83.
The Journal of biological chemistry 1996;271(18):10715-22.
1996: Wei Huang; Kazushi Suzuki; Hideaki Nagase; S Arumugam; Steven R Van Doren; Keith Brew
Folding and characterization of the amino-terminal domain of human tissue inhibitor of metalloproteinases-1 (TIMP-1) expressed at high yield in E. coli.
FEBS letters 1996;384(2):155-61.
1996: Hideaki Nagase; Kazushi Suzuki; Yoshifumi Itoh; CC Kan; M R Gehring; Wei Huang; Keith Brew
Involvement of tissue inhibitors of metalloproteinases (TIMPS) during matrix metalloproteinase activation.
Advances in experimental medicine and biology 1996;389():23-31.
1995: Y Ogata; Yoshifumi Itoh; Hideaki Nagase
Steps involved in activation of the pro-matrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases.
The Journal of biological chemistry 1995;270(31):18506-11.
1995: Yoshifumi Itoh; Hideaki Nagase
Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase.
The Journal of biological chemistry 1995;270(28):16518-21.
1995: Yoshifumi Itoh; S Binner; Hideaki Nagase
Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.
The Biochemical journal 1995;308 ( Pt 2)():645-51.
1995: Hideaki Nagase
Human stromelysins 1 and 2.
Methods in enzymology 1995;248():449-70.
1994: Hideaki Nagase; Yoshifumi Itoh; S Binner
Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their active forms.
Annals of the New York Academy of Sciences 1994;732():294-302.
1994: Hideaki Nagase; C G Fields; Gregg Fields
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).
The Journal of biological chemistry 1994;269(33):20952-7.
1994: Hideaki Nagase
Matrix metalloproteinases. A mini-review.
Contributions to nephrology 1994;107():85-93.
1993: L C Chen; M E Noelken; Hideaki Nagase
Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1).
Biochemistry 1993;32(39):10289-95.
1992: Y Ogata; Michael A Pratta; Hideaki Nagase; Elizabeth C Arner
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) is induced in rabbit articular chondrocytes by cotreatment with interleukin 1 beta and a protein kinase C activator.
Experimental cell research 1992;201(2):245-9.
1992: T Morodomi; Y Ogata; Y Sasaguri; M Morimatsu; Hideaki Nagase
Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells.
The Biochemical journal 1992;285 ( Pt 2)():603-11.
1992: Y Ogata; Jan J Enghild; Hideaki Nagase
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.
The Journal of biological chemistry 1992;267(6):3581-4.
1992: T Morodomi; Kazushi Suzuki; Y Sasaguri; M Morimatsu; Hideaki Nagase
Comparative studies of a 92-kDa gelatinolytic metalloproteinase from U937 cells and matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts.
Matrix (Stuttgart, Germany). Supplement 1992;1():87-8.
1992: Hideaki Nagase; A J Barrett; J F Woessner
Nomenclature and glossary of the matrix metalloproteinases.
Matrix (Stuttgart, Germany). Supplement 1992;1():421-4.
1992: Hideaki Nagase; Kazushi Suzuki; T Morodomi; Jan J Enghild; G Salvesen
Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3.
Matrix (Stuttgart, Germany). Supplement 1992;1():237-44.
1991: Hideaki Nagase; Kazushi Suzuki; Jan J Enghild; G Salvesen
Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin).
Biomedica biochimica acta 1991;50(4-6):749-54.
1990: Kazushi Suzuki; Jan J Enghild; T Morodomi; G Salvesen; Hideaki Nagase
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin).
Biochemistry 1990;29(44):10261-70.
1990: Hideaki Nagase; Jan J Enghild; Kazushi Suzuki; G Salvesen
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.
Biochemistry 1990;29(24):5783-9.
1990: Kazushi Suzuki; Hideaki Nagase; A Ito; Jan J Enghild; G Salvesen
The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():305-10.
1988: Pablo A Bejarano; M E Noelken; Kazushi Suzuki; Billy G Hudson; Hideaki Nagase
Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin).
The Biochemical journal 1988;256(2):413-9.
1988: A Ito; Hideaki Nagase
Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase.
Archives of biochemistry and biophysics 1988;267(1):211-6.
1987: Hideaki Nagase; Keith Brew
Amino acid sequence of a 32-residue region around the thiol ester site in duck ovostatin.
FEBS letters 1987;222(1):83-8.