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Reuven Agami

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Kumsal Ayse Tekirdag; Reuven Agami; Gozde Korkmaz; Deniz Gulfem Ozturk; Devrim Gozuacik
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5.
Carlos A Melo; Sónia A Melo; Joachim A F Oude Vrielink; Harmen van de Werken; Patrick J Wijchers; Wouter de Laat; Elzo de Wit; Jarno Drost; Ran Elkon; Raghu Kalluri; Nicolas Léveillé; Reuven Agami
eRNAs are required for p53-dependent enhancer activity and gene transcription.
Saskia M Wilting; Wina Verlaat; Reuven Agami; Annelieke Jaspers; Nour A Makazaji; Chris J L M Meijer; Peter J F Snijders; Renske D M Steenbergen
Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis.

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All Publications

2013: Kumsal Ayse Tekirdag; Reuven Agami; Gozde Korkmaz; Deniz Gulfem Ozturk; Devrim Gozuacik
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5.
Autophagy 2013;9(3):374-85.
2013: Carlos A Melo; Sónia A Melo; Joachim A F Oude Vrielink; Harmen van de Werken; Patrick J Wijchers; Wouter de Laat; Elzo de Wit; Jarno Drost; Ran Elkon; Raghu Kalluri; Nicolas Léveillé; Reuven Agami
eRNAs are required for p53-dependent enhancer activity and gene transcription.
Molecular cell 2013;49(3):524-35.
2013: Saskia M Wilting; Wina Verlaat; Reuven Agami; Annelieke Jaspers; Nour A Makazaji; Chris J L M Meijer; Peter J F Snijders; Renske D M Steenbergen
Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis.
Epigenetics : official journal of the DNA Methylation Society 2013;8(2):220-8.
2013: Saskia M Wilting; Y Yi; Mark A van de Wiel; Wessel N van Wieringen; W Verlaat; Reuven Agami; A Jaspers; G G Kenter; Carlos le Sage; C J L M Meijer; Gerrit A Meijer; P J F Snijders; Renske D M Steenbergen
Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis.
Oncogene 2013;32(1):106-16.
2012: Adam R Morris; Koos Rooijers; Anne S Bolijn; Arnold Bos; Beatriz Carvalho; Begoña Diosdado; Ran Elkon; Gerrit A Meijer; Reuven Agami
Alternative cleavage and polyadenylation during colorectal cancer development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(19):5256-66.
2012: Mathias Jenal; Uwe Kühn; Fabricio Loayza-Puch; Fiona M Menzies; Koos Rooijers; David C Rubinsztein; Gijs van Haaften; Joachim A F Oude Vrielink; Arnold J Bos; Jarno Drost; Ran Elkon; Reuven Agami
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.
Cell 2012;149(3):538-53.
2012: Gozde Korkmaz; Carlos le Sage; Kumsal Ayse Tekirdag; Reuven Agami; Devrim Gozuacik
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.
Autophagy 2012;8(2):165-76.
2011: Marieke van Kouwenhove; Martijn Kedde; Reuven Agami
MicroRNA regulation by RNA-binding proteins and its implications for cancer.
Nature reviews. Cancer 2011;11(9):644-56.
2011: Mikael Lerner; Josefin Lundgren; Hwee-Fang Ng; Joachim A F Oude Vrielink; Reuven Agami; Shahab Akhoondi; Monique L Den Boer; Dan Grandér; Angelina Jahn; Farhad Akbari Moqadam; Olle Sangfelt
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression.
Cell cycle (Georgetown, Tex.) 2011;10(13):2172-83.
2011: Andrea Caporali; Marco Meloni; Christine Völlenkle; Desiree Bonci; Graciela B Sala-Newby; Roberta Addis; Gaia Spinetti; Sergio Losa; Rachel Masson; Andrew H Baker; Reuven Agami; Carlos le Sage; Gianluigi Condorelli; Paolo Madeddu; Fabio Martelli; Costanza Emanueli
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia.
Circulation 2011;123(3):282-91.
2011: Nicolas Léveillé; Vijayalaxmi Manoharan; Carlos A Melo; Andres Ramos; Jernej Ule; Jelle Wesseling; Joachim Oude Vrielink; Veronica Davalos; Ran Elkon; Manel Esteller; Dave Hollingworth; Hugo M Horlings; Carlos le Sage; Reuven Agami
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.
Nature communications 2011;2():513.
2011: Maria Gomez-Benito; Fabricio Loayza-Puch; Maria D Odero; Joachim Oude Vrielink; Joachim A F Oude Vrielink; Reuven Agami
3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene.
PloS one 2011;6(10):e25449.
2010: Martijn Kedde; Marieke van Kouwenhove; Wilbert Zwart; Joachim A F Oude Vrielink; Ran Elkon; Reuven Agami
A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.
Nature cell biology 2010;12(10):1014-20.
2010: Mati Mann; Omer Barad; Reuven Agami; Benjamin Geiger; Eran Hornstein
miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15804-9.
2010: Fiamma Mantovani; Jarno Drost; P Mathijs Voorhoeve; Giannino Del Sal; Reuven Agami
Gene regulation and tumor suppression by the bromodomain-containing protein BRD7.
Cell cycle (Georgetown, Tex.) 2010;9(14):2777-81.
2010: Aneta M Schaap-Oziemlak; Reinier A P Raymakers; Saskia M Bergevoet; Christian Gilissen; Bastiaan Jan Herman Jansen; Gosse J Adema; Gesine Kögler; Carlos le Sage; Reuven Agami; Bert A van der Reijden; Joop H Jansen
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells.
Stem cells and development 2010;19(6):877-85.
2010: Reuven Agami
microRNAs, RNA binding proteins and cancer.
European journal of clinical investigation 2010;40(4):370-4.
2010: Jarno Drost; Fiamma Mantovani; Francesca Tocco; Ran Elkon; Anna Comel; Henne Holstege; Ron Kerkhoven; Jos Jonkers; P Mathijs Voorhoeve; Reuven Agami; Giannino Del Sal
BRD7 is a candidate tumour suppressor gene required for p53 function.
Nature cell biology 2010;12(4):380-9.
2010: Saskia M Wilting; Robert A A van Boerdonk; Florianne E Henken; Chris J L M Meijer; Begona Diosdado; Gerrit A Meijer; Carlos le Sage; Reuven Agami; Peter J F Snijders; Renske D M Steenbergen
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.
Molecular cancer 2010;9():167.
2010: Ran Elkon; Eitan Zlotorynski; Karen I Zeller; Reuven Agami
Major role for mRNA stability in shaping the kinetics of gene induction.
BMC genomics 2010;11():259.
2010: Gijs van Haaften; Reuven Agami
Tumorigenicity of the miR-17-92 cluster distilled.
Genes & development 2010;24(1):1-4.
2009: Jarno Drost; Reuven Agami
Transformation locked in a loop.
Cell 2009;139(4):654-6.
2009: Remco Nagel; Linda Clijsters; Reuven Agami
The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.
The FEBS journal 2009;276(19):5447-55.
2009: Jason Huse; Cameron Brennan; Dolares Hambardzumyan; Boyoung Wee; John Pena; Sara H Rouhanifard; Cherin Sohn-Lee; Carlos le Sage; Reuven Agami; Thomas Tuschl; Eric C Holland
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
Genes & development 2009;23(11):1327-37.
2009: Andreas Hans Joachim Scheel; Ulrike Beyer; Reuven Agami; Matthias Dobbelstein
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression.
Cell cycle (Georgetown, Tex.) 2009;8(9):1426-32.
2009: Rubén A Bartolomé; Sergio Ferreiro; María E Miquilena-Colina; Lorena Martínez-Prats; María L Soto-Montenegro; David García-Bernal; Juan José Vaquero; Reuven Agami; Rafael Delgado; Manuel Desco; Paloma Sánchez-Mateos; Joaquin Teixidó
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The American journal of pathology 2009;174(2):602-12.
2008: Eitan Zlotorynski; Reuven Agami
A PASport to cellular proliferation.
Cell 2008;134(2):208-10.
2008: Remco Nagel; Carlos le Sage; Begoña Diosdado; Maike van der Waal; Joachim A F Oude Vrielink; Anne Bolijn; Gerrit A Meijer; Reuven Agami
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.
Cancer research 2008;68(14):5795-802.
2008: Anja M Duursma; Martijn Kedde; Mariette Schrier; Carlos le Sage; Reuven Agami
miR-148 targets human DNMT3b protein coding region.
RNA (New York, N.Y.) 2008;14(5):872-7.
2008: Martijn Kedde; Reuven Agami
Interplay between microRNAs and RNA-binding proteins determines developmental processes.
Cell cycle (Georgetown, Tex.) 2008;7(7):899-903.
2008: Qihong Huang; Kiranmai Gumireddy; Mariette Schrier; Carlos le Sage; Remco Nagel; Suresh Nair; David A Egan; Anping Li; Guanghua Huang; Andres J P Klein-Szanto; Phyllis A Gimotty; Dionyssios Katsaros; George Coukos; Lin Zhang; Ellen Puré; Reuven Agami
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis.
Nature cell biology 2008;10(2):202-10.
2008: Ran Elkon; Reuven Agami
Removal of AU bias from microarray mRNA expression data enhances computational identification of active microRNAs.
PLoS computational biology 2008;4(10):e1000189.
2007: Martijn Kedde; Markus J Strasser; Bijan Boldajipour; Joachim A F Oude Vrielink; Krasimir Slanchev; Carlos le Sage; Remco Nagel; P Mathijs Voorhoeve; Josyanne van Duijse; Ulf Ørom; Anders H Lund; Anastassis Perraks; erez raz; Reuven Agami
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.
Cell 2007;131(7):1273-86.
2007: Carlos le Sage; Remco Nagel; Reuven Agami
Diverse ways to control p27Kip1 function: miRNAs come into play.
Cell cycle (Georgetown, Tex.) 2007;6(22):2742-9.
2007: Carlos le Sage; Remco Nagel; David A Egan; Mariette Schrier; Elly Mesman; Annunziato Mangiola; Corrado Anile; Giulio Maira; Neri Mercatelli; Silvia Anna Ciafrè; Maria Giulia Farace; Reuven Agami
Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.
The EMBO journal 2007;26(15):3699-708.
2007: Reuven Agami
All roads lead to IKKepsilon.
Cell 2007;129(6):1043-5.
2007: P Mathijs Voorhoeve; Reuven Agami
Classifying microRNAs in cancer: the good, the bad and the ugly.
Biochimica et biophysica acta 2007;1775(2):274-82.
2007: Yuval Sagiv; Li Bai; Datsen G Wei; Reuven Agami; Paul B Savage; Luc Teyton; Albert Bendelac
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
The Journal of experimental medicine 2007;204(4):921-8.
2007: P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; hans stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.
Advances in experimental medicine and biology 2007;604():17-46.
2006: Martijn Kedde; Carlos le Sage; Anja M Duursma; Eitan Zlotorynski; Bart van Leeuwen; Wouter Nijkamp; Roderick L Beijersbergen; Reuven Agami
Telomerase-independent regulation of ATR by human telomerase RNA.
The Journal of biological chemistry 2006;281(52):40503-14.
2006: Carlos le Sage; Reuven Agami
Immense promises for tiny molecules: uncovering miRNA functions.
Cell cycle (Georgetown, Tex.) 2006;5(13):1415-21.
2006: P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; hans stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.
Cell 2006;124(6):1169-81.
2005: Anja M Duursma; Reuven Agami
CDK-dependent stabilization of Cdc6: linking growth and stress signals to activation of DNA replication.
Cell cycle (Georgetown, Tex.) 2005;4(12):1725-8.
2005: Michal Schwartz; Eitan Zlotorynski; Michal Goldberg; Efrat Ozeri; Ayelet Rahat; Carlos le Sage; Benjamin P C Chen; David J Chen; Reuven Agami; Batsheva Kerem
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.
Genes & development 2005;19(22):2715-26.
2005: Anja M Duursma; Reuven Agami
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.
Molecular and cellular biology 2005;25(16):6937-47.
2005: Ingrid G M Kolfschoten; Bart van Leeuwen; Katrien Berns; Jasper Mullenders; Roderick L Beijersbergen; René Bernards; P Mathijs Voorhoeve; Reuven Agami
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.
Cell 2005;121(6):849-58.
2005: Yulia Einav; Reuven Agami; Dan Canaani
shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts.
FEBS letters 2005;579(1):199-202.
2004: Sladjana Gagrica; Stefanie Hauser; Ingrid Kolfschoten; Lisa Osterloh; Reuven Agami; Stefan Gaubatz
Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein.
The EMBO journal 2004;23(23):4627-38.
2004: Xiaoyan Zhong; Yuxian Shen; Petek Ballar; Andria Apostolou; Reuven Agami; Shengyun Fang
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation.
The Journal of biological chemistry 2004;279(44):45676-84.
2004: P Mathijs Voorhoeve; Reuven Agami
Unraveling human tumor suppressor pathways: a tale of the INK4A locus.
Cell cycle (Georgetown, Tex.) 2004;3(5):616-20.
2004: Katrien Berns; E Marielle Hijmans; Jasper Mullenders; Thijn R Brummelkamp; Arno Velds; Mike Heimerikx; Ron Kerkhoven; Mandy Madiredjo; Wouter Nijkamp; Britta Weigelt; Reuven Agami; Wei Ge; Guy Cavet; Peter Linsley; Roderick L Beijersbergen; René Bernards
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Nature 2004;428(6981):431-7.
2003: P Mathijs Voorhoeve; Reuven Agami
The tumor-suppressive functions of the human INK4A locus.
Cancer cell 2003;4(4):311-9.
2003: Anja M Duursma; Reuven Agami
Ras interference as cancer therapy.
Seminars in cancer biology 2003;13(4):267-73.
2003: Susanne M A Lens; Rob M F Wolthuis; Rob Klompmaker; Jos J W Kauw; Reuven Agami; Thijn R Brummelkamp; Geert J P L Kops; René H Medema
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.
The EMBO journal 2003;22(12):2934-47.
2003: Marc van de Wetering; Irma Oving; Vanesa Muncan; Menno Tjon Pon Fong; Helen Brantjes; Dik van Leenen; Frank C P Holstege; Thijn R Brummelkamp; Reuven Agami; Hans Clevers
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
EMBO reports 2003;4(6):609-15.
2003: P Mathijs Voorhoeve; Reuven Agami
Knockdown stands up.
Trends in biotechnology 2003;21(1):2-4.
2002: Reuven Agami
RNAi and related mechanisms and their potential use for therapy.
Current opinion in chemical biology 2002;6(6):829-34.
2002: Hideo Makimura; Tooru M Mizuno; Jason W Mastaitis; Reuven Agami; Charles V Mobbs
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake.
BMC neuroscience 2002;3():18.
2002: Thijn R Brummelkamp; René Bernards; Reuven Agami
Stable suppression of tumorigenicity by virus-mediated RNA interference.
Cancer cell 2002;2(3):243-7.
2002: Thijn R Brummelkamp; René Bernards; Reuven Agami
A system for stable expression of short interfering RNAs in mammalian cells.
Science (New York, N.Y.) 2002;296(5567):550-3.
2002: Reuven Agami; René Bernards
Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle.
Cancer letters 2002;177(2):111-8.
2000: Reuven Agami; René Bernards
Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.
Cell 2000;102(1):55-66.