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Toshiharu Nagatsu

Research Profile

Chemicals & Drugs

Disorders

Parkinson's Disease

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TOP 3
Akira Nakashima; Akira Ota; Yoko S Kaneko; Keiji Mori; Hiroshi Nagasaki; Toshiharu Nagatsu
A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.
Akira Ota; Takeshi Takayanagi; Mitsuyasu Itoh; Yoko S Kaneko; Kazunao Kondo; Keiji Mori; Hiroshi Nagasaki; Toshiharu Nagatsu; Akira Nakashima; Miyuki Ota
Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells.
K Imamura; N Okayasu; Toshiharu Nagatsu
Cerebral blood flow and freezing of gait in Parkinson's disease.

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2013: Akira Nakashima; Akira Ota; Yoko S Kaneko; Keiji Mori; Hiroshi Nagasaki; Toshiharu Nagatsu
A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.
Journal of neural transmission (Vienna, Austria : 1996) 2013;120(1):49-54.
2012: Akira Ota; Takeshi Takayanagi; Mitsuyasu Itoh; Yoko S Kaneko; Kazunao Kondo; Keiji Mori; Hiroshi Nagasaki; Toshiharu Nagatsu; Akira Nakashima; Miyuki Ota
Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells.
Journal of neural transmission (Vienna, Austria : 1996) 2012;119(11):1327-42.
2012: K Imamura; N Okayasu; Toshiharu Nagatsu
Cerebral blood flow and freezing of gait in Parkinson's disease.
Acta neurologica Scandinavica 2012;126(3):210-8.
2012: Yoko S Kaneko; Keiji Mori; Ikuko Nagatsu; Akira Nakashima; Akira Ota; Toshiharu Nagatsu
Regulation of oxidative stress in long-lived lipopolysaccharide-activated microglia.
Clinical and experimental pharmacology & physiology 2012;39(7):599-607.
2012: Keiji Mori; Hiroshi Nagasaki; Ikuko Nagatsu; Toshiharu Nagatsu; Akira Nakashima; Yoko S Kaneko; Akira Ota
Subventricular zone under the neuroinflammatory stress and Parkinson's disease.
Cellular and molecular neurobiology 2012;32(5):777-85.
2012: Yoko S Kaneko; Keiji Mori; Ikuko Nagatsu; Toshiharu Nagatsu; Akira Nakashima; Akira Ota
Microglial activation in neuroinflammation: implications for the etiology of neurodegeneration.
Neuro-degenerative diseases 2012;10(1-4):100-3.
2011: K Imamura; N Okayasu; Toshiharu Nagatsu
The relationship between depression and regional cerebral blood flow in Parkinson's disease and the effect of selegiline treatment.
Acta neurologica Scandinavica 2011;124(1):28-39.
2011: Akira Nakashima; Keiji Mori; Yoko S Kaneko; Nobuhiro Hayashi; Toshiharu Nagatsu; Akira Ota
Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.
Biochemical and biophysical research communications 2011;407(2):343-7.
2010: Goro Takami; Miyuki Ota; Akira Nakashima; Yoko S Kaneko; Keiji Mori; Toshiharu Nagatsu; Akira Ota
Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase.
Journal of neural transmission (Vienna, Austria : 1996) 2010;117(10):1139-53.
2010: Keiji Mori; Yoko S Kaneko; Akira Nakashima; Toshiharu Nagatsu; Ikuko Nagatsu; Akira Ota
Peripherally injected lipopolysaccharide induces apoptosis in the subventricular zone of young adult mice.
Neuroscience letters 2010;481(2):126-30.
2009: A Nakashima; N Hayashi; Yoko S Kaneko; K Mori; Esther L Sabban; Toshiharu Nagatsu; A Ota
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(11):1355-62.
2009: Yoko S Kaneko; Akira Nakashima; Keiji Mori; Toshiharu Nagatsu; Ikuko Nagatsu; Akira Ota
Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia.
Brain research 2009;1279():9-20.
2008: Akira Ota; Keiji Mori; Yoko S Kaneko; Akira Nakashima; Ikuko Nagatsu; Toshiharu Nagatsu
Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice.
Annals of the New York Academy of Sciences 2008;1148():127-35.
2008: Hideki Miura; Norio Ozaki; Makoto Sawada; Kenichi Isobe; Tatsuro Ohta; Toshiharu Nagatsu
A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression.
Stress (Amsterdam, Netherlands) 2008;11(3):198-209.
2008: Makoto Sawada; Hirohide Sawada; Toshiharu Nagatsu
Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases.
Neuro-degenerative diseases 2008;5(3-4):254-6.
2007: Akira Nakashima; Nobuhiro Hayashi; Yoko S Kaneko; Keiji Mori; Esther L Sabban; Toshiharu Nagatsu; Akira Ota
RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.
Biochemical and biophysical research communications 2007;363(3):817-21.
2007: Hiroshi Ichinose; Toshiharu Nagatsu
[Identification of the causative gene for Segawa's disease].
Rinshō shinkeigaku = Clinical neurology 2007;47(11):735-8.
2007: Akira Ota; Yoko S Kaneko; Keiji Mori; Akira Nakashima; Ikuko Nagatsu; Toshiharu Nagatsu
Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.
Stress (Amsterdam, Netherlands) 2007;10(2):131-6.
2007: Hirohide Sawada; Ryohei Hishida; Yoko Hirata; Kenji Ono; Hiromi Suzuki; Shin-ichi Muramatsu; Imaharu Nakano; Toshiharu Nagatsu; Makoto Sawada
Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Journal of neuroscience research 2007;85(8):1752-61.
2007: Hirohide Sawada; Hiroshi Ishiguro; Kazuhiro Nishii; Kouji Yamada; Kunihiro Tsuchida; Hisahide Takahashi; Jun Goto; Ichiro Kanazawa; Toshiharu Nagatsu
Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice.
Neuroscience research 2007;57(4):559-73.
2007: Makio Mogi; Tomoyoshi Kondo; Yoshikuni Mizuno; Toshiharu Nagatsu
p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.
Neuroscience letters 2007;414(1):94-7.
2007: Toshiharu Nagatsu; M Sawada
Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects.
Journal of neural transmission. Supplementum 2007;(72):113-20.
2006: Joseph R Mazzulli; Amanda J Mishizen; Benoit I Giasson; David R Lynch; Steven A Thomas; Akira Nakashima; Toshiharu Nagatsu; Akira Ota; Harry Ischiropoulos
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):10068-78.
2006: Toshiharu Nagatsu; M Sawada
Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells.
Journal of neural transmission. Supplementum 2006;(71):53-65.
2006: M Sawada; K Imamura; Toshiharu Nagatsu
Role of cytokines in inflammatory process in Parkinson's disease.
Journal of neural transmission. Supplementum 2006;(70):373-81.
2005: Kazuto Kobayashi; Toshiharu Nagatsu
Molecular genetics of tyrosine 3-monooxygenase and inherited diseases.
Biochemical and biophysical research communications 2005;338(1):267-70.
2005: Yoko Hirata; Toshiharu Nagatsu
Rotenone and CCCP inhibit tyrosine hydroxylation in rat striatal tissue slices.
Toxicology 2005;216(1):9-14.
2005: Akira Nakashima; Nobuhiro Hayashi; Yoko S Kaneko; Keiji Mori; Hiromi Egusa; Toshiharu Nagatsu; Akira Ota
Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.
Journal of neuroscience research 2005;81(1):110-20.
2005: Kiyofumi Yamada; Hiroshi Ishiguro; N Ichino; Kazuhiro Nishii; Hirohide Sawada; T Hida; Toshiharu Nagatsu
Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding protein are controlled by withdrawal of nicotine from cultured pheochromocytoma PC12 cells.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(5):633-9.
2005: Kazuhiro Imamura; Nozomi Hishikawa; Kenji Ono; Hiromi Suzuki; Makoto Sawada; Toshiharu Nagatsu; Mari Yoshida; Yoshio Hashizume
Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.
Acta neuropathologica 2005;109(2):141-50.
2005: Toshiharu Nagatsu; M Sawada
Inflammatory process in Parkinson's disease: role for cytokines.
Current pharmaceutical design 2005;11(8):999-1016.
2004: R Hashimoto; Toshiharu Nagatsu; T Ohta; M Mizutani; I Omura
Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression.
Annals of the New York Academy of Sciences 2004;1018():378-86.
2004: Toshiharu Nagatsu
Progress in monoamine oxidase (MAO) research in relation to genetic engineering.
Neurotoxicology 2004;25(1-2):11-20.
2003: Kazuhiro Imamura; Nozomi Hishikawa; Makoto Sawada; Toshiharu Nagatsu; Mari Yoshida; Yoshio Hashizume
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.
Acta neuropathologica 2003;106(6):518-26.
2003: Hiroaki Shiraishi; Taiya Kato; Koji Atsuta; Chiho Sumi-Ichinose; Masatsugu Ohtsuki; Mitsuyasu Itoh; Hitoshi Hishida; Shin Tada; Yasuhiro Udagawa; Toshiharu Nagatsu; Yasumichi Hagino; Hiroshi Ichinose; Takahide Nomura
cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.
Journal of pharmacological sciences 2003;93(3):265-71.
2003: Kohei Yuyama; Hideko Yamamoto; Kazuhiro Nakamura; Itone Nishizaki; Tohru Yamakuni; Si-Young Song; Ichiro Sora; Toshiharu Nagatsu; Toshifumi Yamamoto
Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis.
Journal of neuroscience research 2003;72(6):716-25.
2003: Shin-ichiro Ikebe; Toshiaki Harada; Takao Hashimoto; Ichiro Kanazawa; Sadako Kuno; Yoshikuni Mizuno; Eiji Mizuta; Miho Murata; Toshiharu Nagatsu; Shigenobu Nakamura; Hideki Takubo; Nobuo Yanagisawa; Hirotaro Narabayashi
Prevention and treatment of malignant syndrome in Parkinson's disease: a consensus statement of the malignant syndrome research group.
Parkinsonism & related disorders 2003;9 Suppl 1():S47-9.
2003: Hideki Takubo; Toshihide Harada; Takao Hashimoto; Yutaka Inaba; Ichiro Kanazawa; Sadako Kuno; Yoshikuni Mizuno; Eiji Mizuta; Miho Murata; Toshiharu Nagatsu; Shigenobu Nakamura; Nobuo Yanagisawa; Hirotaro Narabayashi
A collaborative study on the malignant syndrome in Parkinson's disease and related disorders.
Parkinsonism & related disorders 2003;9 Suppl 1():S31-41.
2003: Hiroshi Ichinose; Tamae Ohye; Hitoshi Shinotoh; Kimihito Arai; Shunzo Yamazaki; Eiji Mizuta; Sadako Kuno; Toshiharu Nagatsu
Biopterin metabolism in patients with malignant syndrome.
Parkinsonism & related disorders 2003;9 Suppl 1():S11-4.
2003: Yan-Yan Lu; Li-Jun Wang; Shin-ichi Muramatsu; Kunihiko Ikeguchi; Ken-ichi Fujimoto; Takashi Okada; Hiroaki Mizukami; Takashi Matsushita; Yutaka Hanazono; Akihiro Kume; Toshiharu Nagatsu; Keiya Ozawa; Imaharu Nakano
Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.
Neuroscience research 2003;45(1):33-40.
2002: Keiko Ikemoto; Takahiro Suzuki; Hiroshi Ichinose; Tamae Ohye; Akiyoshi Nishimura; Katsuji Nishi; Ikuko Nagatsu; Toshiharu Nagatsu
Localization of sepiapterin reductase in the human brain.
Brain research 2002;954(2):237-46.
2002: Tohru Yamakuni; Takahiro Suzuki; Hideo Inagaki; Yasushi Ohizumi; Toshiharu Nagatsu; Hiroshi Ichinose
[V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):82P-84P.
2002: Toshiharu Nagatsu
Amine-related neurotoxins in Parkinson's disease: past, present, and future.
Neurotoxicology and teratology 2002;24(5):565-9.
2002: Li-Jun Wang; Yan-Yan Lu; Shin-ichi Muramatsu; Kunihiko Ikeguchi; Ken-ichi Fujimoto; Takashi Okada; Hiroaki Mizukami; Takashi Matsushita; Yutaka Hanazono; Akihiro Kume; Toshiharu Nagatsu; Keiya Ozawa; Imaharu Nakano
Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(16):6920-8.
2002: N Ichino; Kiyofumi Yamada; Kazuhiro Nishii; Hirohide Sawada; Toshiharu Nagatsu; Hiroshi Ishiguro
Increase of transcriptional levels of egr-1 and nur77 genes due to both nicotine treatment and withdrawal in pheochromocytoma cells.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(7-8):1015-22.
2002: Akira Nakashima; Yoko S Kaneko; Keiji Mori; Kentaro Fujiwara; Toshimitsu Tsugu; Takahiro Suzuki; Toshiharu Nagatsu; Akira Ota
The mutation of two amino acid residues in the N-terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT-20 cells.
Journal of neurochemistry 2002;82(1):202-6.
2002: Takahiro Suzuki; Hidehito Inagaki; Tohru Yamakuni; Toshiharu Nagatsu; Hiroshi Ichinose
Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells.
Biochemical and biophysical research communications 2002;293(3):962-8.
2002: Toshiharu Nagatsu
Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(5-6):731-45.
2002: Masatsugu Ohtsuki; Hiroaki Shiraishi; Taiya Kato; Risa Kuroda; Masahiro Tazawa; Chiho Sumi-Ichinose; Shin Tada; Yasutoshi Udagawa; Mitsuyasu Itoh; Hitoshi Hishida; Hiroshi Ichinose; Toshiharu Nagatsu; Yasumichi Hagino; Takahide Nomura
cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.
Life sciences 2002;70(18):2187-98.
2002: Lijun Wang; Shin-ichi Muramatsu; Y Lu; Kunihiko Ikeguchi; Ken-Ichi Fujimoto; Takashi Okada; Hiroaki Mizukami; Yutaka Hanazono; Akihiro Kume; Fumi Urano; Hiroshi Ichinose; Toshiharu Nagatsu; Imaharu Nakano; Keiya Ozawa
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease.
Gene therapy 2002;9(6):381-9.
2002: Shin-ichi Muramatsu; Ken-Ichi Fujimoto; Kunihiko Ikeguchi; Nami Shizuma; Katsuyoshi Kawasaki; Fumiko Ono; Yang Shen; Lijun Wang; Hiroaki Mizukami; Akihiro Kume; Masaru Matsumura; Ikuko Nagatsu; Fumi Urano; Hiroshi Ichinose; Toshiharu Nagatsu; Keiji Terao; Imaharu Nakano; Keiya Ozawa
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
Human gene therapy 2002;13(3):345-54.
2002: Kazuhisa Ikemoto; Takashi Sugimoto; Shizuaki Murata; Masahiro Tazawa; Takahide Nomura; Hiroshi Ichinose; Toshiharu Nagatsu
(6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin.
Biological chemistry 2002;383(2):325-30.
2002: Takahiko Kawasaki; Yoko Bekku; Fumikazu Suto; Takashi Kitsukawa; Masahiko Taniguchi; Ikuko Nagatsu; Toshiharu Nagatsu; Kazuo Itoh; Takeshi Yagi; Hajime Fujisawa
Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system.
Development (Cambridge, England) 2002;129(3):671-80.
2001: Chiho Sumi-Ichinose; F Urano; Risa Kuroda; Tamae Ohye; M Kojima; Masahiro Tazawa; Hiroaki Shiraishi; Yasumichi Hagino; Toshiharu Nagatsu; Takahide Nomura; Hiroshi Ichinose
Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice.
The Journal of biological chemistry 2001;276(44):41150-60.
2001: Tamae Ohye; Hiroshi Ichinose; T Yoshizawa; I Kanazawa; Toshiharu Nagatsu
A new splicing variant for human tyrosine hydroxylase in the adrenal medulla.
Neuroscience letters 2001;312(3):157-60.
2001: Yoko Hirata; Kazutoshi Kiuchi; Toshiharu Nagatsu
Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices.
Neuroscience letters 2001;311(1):53-6.
2001: Hiroshi Ishiguro; Hirohide Sawada; Kazuhiro Nishii; Kiyofumi Yamada; Toshiharu Nagatsu
[Huntington's disease model mouse and neuronal cell death].
Nō to shinkei = Brain and nerve 2001;53(9):829-37.
2001: Hiroshi Ishiguro; Kiyofumi Yamada; Hirohide Sawada; Kazuhiro Nishii; N Ichino; M Sawada; Yoshikazu Kurosawa; Natsuki Matsushita; Kazuto Kobayashi; Jun Goto; H Hashida; N Masuda; Ichiro Kanazawa; Toshiharu Nagatsu
Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.
Journal of neuroscience research 2001;65(4):289-97.
2001: Yoko S Kaneko; Keiji Mori; Akira Nakashima; Ikuko Nagatsu; Toshiharu Nagatsu; Akira Ota
Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection.
Brain research. Brain research protocols 2001;8(1):25-31.
2001: M Ota; A Nakashima; Keiko Ikemoto; S Nojima; M Tanaka; M Okuda; H Koga; K Mori; Y S Kaneko; K Fujiwara; H Yamamoto; Toshiharu Nagatsu; A Ota
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients.
Molecular psychiatry 2001;6(3):315-9.
2001: Makio Mogi; Akifumi Togari; T Kondo; Yoshikuni Mizuno; O Kogure; S Kuno; H Ichinose; Toshiharu Nagatsu
Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains.
Neuroscience letters 2001;300(3):179-81.
2001: Hiroshi Ichinose; T Suzuki; Hidehito Inagaki; Tamae Ohye; Toshiharu Nagatsu
DOPA-responsive dystonia. From causative gene to molecular mechanism.
Advances in neurology 2001;86():173-6.
2001: Peter Riederer; Heinz Reichmann; B Janetzky; jeswinder sian; Klaus-Peter Lesch; K W Lange; Kay L Double; Toshiharu Nagatsu; Manfred Gerlach
Neural degeneration in Parkinson's disease.
Advances in neurology 2001;86():125-36.
2000: Kiyofumi Yamada; N Ichino; Kazuhiro Nishii; Hirohide Sawada; S Higashiyama; Hiroshi Ishiguro; Toshiharu Nagatsu
Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA.
Gene 2000;255(1):15-24.
2000: Rolf J R J Janssen; Ron A Wevers; Martin Häussler; JA Luyten; Gerry C H Steenbergen-Spanjers; Georg F Hoffmann; Toshiharu Nagatsu; Lambert P van den Heuvel
A branch site mutation leading to aberrant splicing of the human tyrosine hydroxylase gene in a child with a severe extrapyramidal movement disorder.
Annals of human genetics 2000;64(Pt 5):375-82.
2000: Masahiro Tazawa; Masatsugu Ohtsuki; Chiho Sumi-Ichinose; Hiroaki Shiraishi; Risa Kuroda; Yasumichi Hagino; S Nakashima; Y Nozawa; Hiroshi Ichinose; Toshiharu Nagatsu; Takahide Nomura
GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;127(1):65-73.
2000: Hiroshi Ichinose; Hidehito Inagaki; T Suzuki; Tamae Ohye; Toshiharu Nagatsu
Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease.
Brain & development 2000;22 Suppl 1():S107-10.
2000: T Maeda; S Haeno; K Oda; D Mori; H Ichinose; Toshiharu Nagatsu; T Suzuki
Studies on the genotype-phenotype relation in the hph-1 mouse mutant deficient in guanosine triphosphate (GTP) cyclohydrolase I activity.
Brain & development 2000;22 Suppl 1():S50-3.
2000: Takayoshi Shimohata; T Nakajima; M Yamada; C Uchida; Osamu Onodera; Satoshi Naruse; T Kimura; Reiji Koide; Kenkichi Nozaki; Yasuteru Sano; H Ishiguro; Kumi Sakoe; T Ooshima; Aki Sato; Takeshi Ikeuchi; Mutsuo Oyake; T Sato; Y Aoyagi; Isao Hozumi; Toshiharu Nagatsu; Yoshihisa Takiyama; Masatoyo Nishizawa; Jun Goto; Ichiro Kanazawa; I Davidson; Naoko Tanese; Hidenobu Takahashi; Shoji Tsuji
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
Nature genetics 2000;26(1):29-36.
2000: Makio Mogi; Akifumi Togari; K Tanaka; N Ogawa; H Ichinose; Toshiharu Nagatsu
Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506.
Neuroscience letters 2000;289(3):165-8.
2000: Shuji Kaneko; Tsutomu Hikida; Dai Watanabe; H Ichinose; Toshiharu Nagatsu; R J Kreitman; Ira Pastan; Shigetada Nakanishi
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Science (New York, N.Y.) 2000;289(5479):633-7.
2000: Yang Shen; Shin-ichi Muramatsu; Kunihiko Ikeguchi; Ken-Ichi Fujimoto; DS Fan; M Ogawa; Hiroaki Mizukami; Masashi Urabe; Akihiro Kume; Ikuko Nagatsu; Fumi Urano; T Suzuki; Hiroshi Ichinose; Toshiharu Nagatsu; J Monahan; Imaharu Nakano; Keiya Ozawa
Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.
Human gene therapy 2000;11(11):1509-19.
2000: Jiro Usukura; Y Nishizawa; A Shimomura; K Kobayashi; Toshiharu Nagatsu; Masatoshi Hagiwara
Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(6):515-22.
2000: N Nakano; Shigeki Higashiyama; K Kajihara; T Endo; H Ishiguro; Kiyofumi Yamada; Toshiharu Nagatsu; Naoyuki Taniguchi
NTAKalpha and beta isoforms stimulate breast tumor cell growth by means of different receptor combinations.
Journal of biochemistry 2000;127(5):925-30.
2000: M Hibiya; H Ichinose; N Ozaki; K Fujita; T Nishimoto; T Yoshikawa; Y Asano; Toshiharu Nagatsu
Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;740(1):35-42.
2000: Kazuto Kobayashi; Y Noda; Natsuki Matsushita; K Nishii; H Sawada; Toshiharu Nagatsu; D Nakahara; R Fukabori; Yasunobu Yasoshima; T Yamamoto; M Miura; M Kano; T Mamiya; Y Miyamoto; T Nabeshima
Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(6):2418-26.
2000: A Nakashima; N Hayashi; K Mori; Y S Kaneko; Toshiharu Nagatsu; A Ota
Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1.
FEBS letters 2000;465(1):59-63.
2000: Toshiharu Nagatsu; M Mogi; Hiroshi Ichinose; A Togari
Changes in cytokines and neurotrophins in Parkinson's disease.
Journal of neural transmission. Supplementum 2000;(60):277-90.
2000: Toshiharu Nagatsu; M Mogi; Hiroshi Ichinose; A Togari
Cytokines in Parkinson's disease.
Journal of neural transmission. Supplementum 2000;(58):143-51.
2000: Makio Mogi; Akifumi Togari; T Kondo; Yoshikuni Mizuno; O Komure; S Kuno; H Ichinose; Toshiharu Nagatsu
Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(3):335-41.
1999: Hiroshi Ichinose; T Suzuki; Hidehito Inagaki; Tamae Ohye; Toshiharu Nagatsu
Molecular genetics of dopa-responsive dystonia.
Biological chemistry 1999;380(12):1355-64.
1999: Takahiro Suzuki; Tamae Ohye; Hidehito Inagaki; Toshiharu Nagatsu; Hiroshi Ichinose
Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: relationship to etiology of dopa-responsive dystonia.
Journal of neurochemistry 1999;73(6):2510-6.
1999: Chiharu Itagaki; Toshiaki Isobe; Masato Taoka; Tohru Natsume; N Nomura; Tsuneyoshi Horigome; Saburo Omata; H Ichinose; Toshiharu Nagatsu; L A Greene; Tohru Ichimura
Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.
Biochemistry 1999;38(47):15673-80.
1999: Hideki Hida; M Hashimoto; I Fujimoto; K Nakajima; Yasunobu Shimano; Toshiharu Nagatsu; Katsuhiko Mikoshiba; Hoyoku Nishino
Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats.
Neuroscience research 1999;35(2):101-12.
1999: N Ichino; Hiroshi Ishiguro; Kiyofumi Yamada; Kazuhiro Nishii; Hirohide Sawada; Toshiharu Nagatsu
Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells.
Neuroscience research 1999;35(1):63-9.
1999: Nobuyuki Karasawa; Y Yamawaki; Toshiharu Nagatsu; T Kawase; K Nishiyama; K Watanabe; Minoru Onozuka; Ikuko Nagatsu
Age-associated changes in the dopamine synthesis as determined by GTP cyclohydrolase I inhibitor in the brain of senescence-accelerated mouse-prone inbred strains (SAMP8).
Neuroscience research 1999;35(1):31-6.
1999: Makio Mogi; Akifumi Togari; T Kondo; Yoshikuni Mizuno; O Komure; S Kuno; H Ichinose; Toshiharu Nagatsu
Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.
Neuroscience letters 1999;270(1):45-8.
1999: Hidehito Inagaki; Tamae Ohye; T Suzuki; M Segawa; Y Nomura; Toshiharu Nagatsu; Hiroshi Ichinose
Decrease in GTP cyclohydrolase I gene expression caused by inactivation of one allele in hereditary progressive dystonia with marked diurnal fluctuation.
Biochemical and biophysical research communications 1999;260(3):747-51.
1999: Makio Mogi; Akifumi Togari; K Tanaka; N Ogawa; H Ichinose; Toshiharu Nagatsu
Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction.
Neuroscience letters 1999;268(2):101-4.
1999: Kengo Fujimoto; H Ichinose; Toshiharu Nagatsu; T Nonaka; Y Mitsui; Setsuko Katoh
Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase.
Biochimica et biophysica acta 1999;1431(2):306-14.
1999: Akira Nakashima; Keiji Mori; T Suzuki; H Kurita; M Otani; Toshiharu Nagatsu; Akira Ota
Dopamine inhibition of human tyrosine hydroxylase type 1 is controlled by the specific portion in the N-terminus of the enzyme.
Journal of neurochemistry 1999;72(5):2145-53.
1999: Hiroshi Ichinose; Tamae Ohye; T Suzuki; Chiho Sumi-Ichinose; T Nomura; Yasumichi Hagino; Toshiharu Nagatsu
Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs.
Gene 1999;230(2):233-9.
1999: Hiroshi Ichinose; Tamae Ohye; T Suzuki; Hidehito Inagaki; Toshiharu Nagatsu
[The relation between metabolism of biopterin and dystonia-parkinsonism].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 1999;19(2):85-9.
1999: Toshiharu Nagatsu; Hiroshi Ichinose
Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin.
Molecular neurobiology 1999;19(1):79-96.
1999: Toshiharu Nagatsu; H Ichinose
Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease.
Cellular and molecular neurobiology 1999;19(1):57-66.
1999: Ikuko Nagatsu; Keiko Ikemoto; Kunio Kitahama; Akiyoshi Nishimura; H Ichinose; Toshiharu Nagatsu
Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(7-8):607-17.
1999: A Nakashima; K Mori; Toshiharu Nagatsu; A Ota
Expression of human tyrosine hydroxylase type I in Escherichia coli as a protease-cleavable fusion protein. Short communication.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(9-10):819-24.
1999: Hiroshi Ichinose; Toshiharu Nagatsu
Molecular genetics of DOPA-responsive dystonia.
Advances in neurology 1999;80():195-8.
1999: M Mogi; Toshiharu Nagatsu
Neurotrophins and cytokines in Parkinson's disease.
Advances in neurology 1999;80():135-9.
1998: D Fan; D Kang; M Ogawa; I Nakano; Toshiharu Nagatsu; G J Kurtzman; K Ozawa
Cotransduction of tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes into cultured striatal cells using adeno-associated virus vectors.
Chinese medical journal 1998;111(12):1111-3.
1998: DS Fan; M Ogawa; Ken-Ichi Fujimoto; Kunihiko Ikeguchi; Yoji Ogasawara; Masashi Urabe; Masatoyo Nishizawa; Imaharu Nakano; M Yoshida; Ikuko Nagatsu; Hiroshi Ichinose; Toshiharu Nagatsu; GJ Kurtzman; Keiya Ozawa
Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors.
Human gene therapy 1998;9(17):2527-35.
1998: Kazuhiro Nishii; Natsuki Matsushita; Hirohide Sawada; H Sano; Y Noda; T Mamiya; T Nabeshima; I Nagatsu; T Hata; K Kiuchi; H Yoshizato; K Nakashima; Toshiharu Nagatsu; Kazuto Kobayashi
Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission.
Journal of neuroscience research 1998;54(4):450-64.
1998: Tamae Ohye; T A Hori; S Katoh; Toshiharu Nagatsu; Hiroshi Ichinose
Genomic organization and chromosomal localization of the human sepiapterin reductase gene.
Biochemical and biophysical research communications 1998;251(2):597-602.
1998: Dai Watanabe; H Inokawa; K Hashimoto; N Suzuki; M Kano; R Shigemoto; T Hirano; K Toyama; Shuji Kaneko; M Yokoi; Koki Moriyoshi; Misao Suzuki; K Kobayashi; Toshiharu Nagatsu; R J Kreitman; Ira Pastan; Shigetada Nakanishi
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Cell 1998;95(1):17-27.
1998: Keiko Ikemoto; Ikuko Nagatsu; S Ito; R A King; Akiyoshi Nishimura; Toshiharu Nagatsu
Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
Neuroscience letters 1998;253(3):198-200.
1998: Hiroshi Ishiguro; Kiyofumi Yamada; N Ichino; Toshiharu Nagatsu
Identification and characterization of a novel phorbol ester-responsive DNA sequence in the 5'-flanking region of the human dopamine beta-hydroxylase gene.
The Journal of biological chemistry 1998;273(34):21941-9.
1998: Hiroshi Ishiguro; S Higashiyama; Kiyofumi Yamada; N Ichino; N Taniguchi; Toshiharu Nagatsu
[Structure and function of a novel ErbB ligand, NTAK].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 1998;18(4):137-42.
1998: Takahide Nomura; Masahiro Tazawa; Masatsugu Ohtsuki; Chiho Sumi-Ichinose; Yasumichi Hagino; A Ota; A Nakashima; K Mori; T Sugimoto; O Ueno; Y Nozawa; Hiroshi Ichinose; Toshiharu Nagatsu
Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1998;120(4):753-60.
1998: Makio Mogi; Akifumi Togari; M Ogawa; Kunihiko Ikeguchi; N Shizuma; D Fan; Imaharu Nakano; Toshiharu Nagatsu
Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.
Neuroscience letters 1998;250(1):25-8.
1998: Akifumi Togari; M Arai; Makio Mogi; Ayami Kondo; Toshiharu Nagatsu
Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines.
FEBS letters 1998;428(3):212-6.
1998: D Fan; M Ogawa; Kunihiko Ikeguchi; Ken-Ichi Fujimoto; Masashi Urabe; Akihiro Kume; Masatoyo Nishizawa; N Matsushita; K Kiuchi; Hiroshi Ichinose; Toshiharu Nagatsu; GJ Kurtzman; Imaharu Nakano; Keiya Ozawa
Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro.
Neuroscience letters 1998;248(1):61-4.
1998: Toshiharu Nagatsu; Hiroshi Ichinose
[Autosomal-dominant DOPA-responsive dystonia, caused by mutations in the GTP-cyclohydrolase I gene].
Voprosy medit͡sinskoĭ khimii 1998;44(3):225-8.
1998: T Imaoka; Isao Date; Takashi Ohmoto; Toshiharu Nagatsu
Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex.
Human gene therapy 1998;9(7):1093-102.
1998: Ikuko Nagatsu; Keiko Ikemoto; T Takeuchi; Ryohachi Arai; Nobuyuki Karasawa; T Fujii; Toshiharu Nagatsu
Phenylethanolamine-N-methyltransferase - immunoreactive nerve terminals afferent to the mouse substantia nigra.
Neuroscience letters 1998;245(1):41-4.
1998: Toshiharu Nagatsu; H Ichinose
[Molecular biology of hereditary dystonia].
No to hattatsu. Brain and development 1998;30(2):93-100.
1998: Hirohide Sawada; Kazuhiro Nishii; T Suzuki; K Hasegawa; T Hata; I Nagatsu; R J Kreitman; Ira Pastan; Toshiharu Nagatsu; Kazuto Kobayashi
Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system.
Journal of neuroscience research 1998;51(2):162-73.
1998: Ikuko Nagatsu; M Sakai; Nobuyuki Karasawa; T Takeuchi; Ryohachi Arai; K Yamada; Toshiharu Nagatsu
Immunocytochemical evidence of novel catecholamine- or biopterin-related neurons of mammalian brain.
Advances in pharmacology (San Diego, Calif.) 1998;42():859-62.
1998: Toshiharu Nagatsu; Hiroshi Ichinose
Genetic basis of dominant dystonia.
Advances in pharmacology (San Diego, Calif.) 1998;42():44-7.
1998: Toshiharu Nagatsu; L Stjärne
Catecholamine synthesis and release. Overview.
Advances in pharmacology (San Diego, Calif.) 1998;42():1-14.
1997: K Mori; A Nakashima; Toshiharu Nagatsu; A Ota
Effect of lipopolysaccharide on the gene expression of the enzymes involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line N1E-115.
Neuroscience letters 1997;238(1-2):21-4.
1997: Toshiharu Nagatsu
Isoquinoline neurotoxins in the brain and Parkinson's disease.
Neuroscience research 1997;29(2):99-111.
1997: Akifumi Togari; Michitsugu Arai; S Mizutani; S Mizutani; Yasuko Koshihara; Toshiharu Nagatsu
Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells.
Neuroscience letters 1997;233(2-3):125-8.
1997: Shigeki Higashiyama; M Horikawa; Kiyofumi Yamada; N Ichino; N Nakano; Takatoshi Nakagawa; Jun-ichiro Miyagawa; N Matsushita; Toshiharu Nagatsu; Naoyuki Taniguchi; H Ishiguro
A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.
Journal of biochemistry 1997;122(3):675-80.
1997: A Ota; A Nakashima; K Mori; Toshiharu Nagatsu
Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli.
Neuroscience letters 1997;229(1):57-60.
1997: Ikuko Nagatsu; M Sakai; T Takeuchi; Ryohachi Arai; Nobuyuki Karasawa; K Yamada; Toshiharu Nagatsu
Tyrosine hydroxylase (TH)-only-immunoreactive non-catecholaminergic neurons in the brain of wild mice or the human TH transgenic mice do not contain GTP cyclohydrolase I.
Neuroscience letters 1997;228(1):55-7.
1997: Hiroshi Ishiguro; N Ichino; Kiyofumi Yamada; Toshiharu Nagatsu
Nicotine regulates mRNA level of tyrosine hydroxylase gene but not that of nicotinic acetylcholine receptor genes in PC12 cells.
Neuroscience letters 1997;228(1):37-40.
1997: M Hibiya; R Teradaira; K Shimpo; T Matsui; T Sugimoto; Toshiharu Nagatsu
Interference of a methotrexate derivative with urinary oncopterin [N2-(3-aminopropyl)biopterin] measurement by high-performance liquid chromatography with fluorimetric detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(1):223-7.
1997: Ikuko Nagatsu; Ryohachi Arai; M Sakai; Y Yamawaki; T Takeuchi; Nobuyuki Karasawa; Toshiharu Nagatsu
Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase.
Neuroscience letters 1997;224(3):185-8.
1997: Nobuyuki Karasawa; Ryohachi Arai; G Isomura; Toshiharu Nagatsu; Ikuko Nagatsu
Coexistence of tyrosine hydroxylase and serotonin in the raphe nucleus of the laboratory shrew (Suncus murinus) during postnatal life.
Brain research. Developmental brain research 1997;99(1):121-5.
1997: Nobuyuki Karasawa; Ikuko Nagatsu; K Sakai; Toshiharu Nagatsu; K Watanabe; Minoru Onozuka
Immunocytochemical study of catecholaminergic neurons in the senescence-accelerated mouse (SAM-P8) brain.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1267-75.
1997: Toshiharu Nagatsu; Hiroshi Ichinose
GTP cyclohydrolase I gene, dystonia, juvenile parkinsonism, and Parkinson's disease.
Journal of neural transmission. Supplementum 1997;49():203-9.
1997: H Ichinose; Toshiharu Nagatsu
Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene.
Brain research bulletin 1997;43(1):35-8.
1996: M Mogi; M Harada; T Kondo; Yoshikuni Mizuno; H Narabayashi; Peter Riederer; Toshiharu Nagatsu
The soluble form of Fas molecule is elevated in parkinsonian brain tissues.
Neuroscience letters 1996;220(3):195-8.
1996: A Ota; S Yoshida; T Nomura; S Matsui; Y Hagino; K Umezawa; S Katoh; Toshiharu Nagatsu
Tetrahydrobiopterin biosynthesis enhanced by lipopolysaccharide stimulation in murine neuroblastoma cell line N1E-115.
Journal of neurochemistry 1996;67(6):2540-8.
1996: Kazuto Kobayashi; Tamae Ohye; Ira Pastan; Toshiharu Nagatsu
A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting.
Nucleic acids research 1996;24(18):3653-5.
1996: M Mogi; M Harada; T Kondo; Yoshikuni Mizuno; H Narabayashi; Peter Riederer; Toshiharu Nagatsu
bcl-2 protein is increased in the brain from parkinsonian patients.
Neuroscience letters 1996;215(2):137-9.
1996: Ikuko Nagatsu; T Takeuchi; M Sakai; Ryohachi Arai; Nobuyuki Karasawa; Toshiharu Nagatsu
Transient appearance of GTP cyclohydrolase I--positive non-monoaminergic neurons in the ventral lateral geniculate nucleus of postnatal mice.
Neuroscience letters 1996;215(2):79-82.
1996: S Yoshida; A Ota; K Umezawa; Toshiharu Nagatsu
Dissociated release of tetrahydrobiopterin and nitric oxide by lipopolysaccharide from mouse neuroblastoma cells.
Neuroscience letters 1996;212(2):135-8.
1996: Ikuko Nagatsu; T Takeuchi; M Sakai; Nobuyuki Karasawa; Y Yamawaki; Ryohachi Arai; Toshiharu Nagatsu
Transient appearance of tyrosine hydroxylase-immunoreactive non-catecholaminergic neurons in the medial geniculate nucleus of postnatal mice.
Neuroscience letters 1996;211(3):183-6.
1996: M Mogi; M Harada; H Narabayashi; H Inagaki; M Minami; Toshiharu Nagatsu
Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.
Neuroscience letters 1996;211(1):13-6.
1996: K Shimpo; T Chihara; M Hibiya; S Ito; Toshiharu Nagatsu
[Amines and pteridines].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(6):1515-20.
1996: Hiroshi Ichinose; Toshiharu Nagatsu
[Molecular genetics of hereditary progressive dystonia (HPD/Segawa's disease)].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(5):1453-9.
1996: Toshiharu Nagatsu; H Ichinose
GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism.
Neurochemical research 1996;21(2):245-50.
1996: A Ota; S Yoshida; Toshiharu Nagatsu
Regulation of N-terminus-deleted human tyrosine hydroxylase type 1 by end products of catecholamine biosynthetic pathway.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(12):1415-28.
1996: Chiho Sumi-Ichinose; S Hasegawa; M Ohtsuki; H Nomura; Takahide Nomura; Yasumichi Hagino; K Fujita; Toshiharu Nagatsu
Analysis of an alternative promoter that regulates tissue-specific expression of the human aromatic L-amino acid decarboxylase gene in cultured cell lines.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(1-2):1-15.
1996: M Mogi; M Harada; T Kondo; Peter Riederer; Toshiharu Nagatsu
Interleukin-2 but not basic fibroblast growth factor is elevated in parkinsonian brain. Short communication.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(8-9):1077-81.
1996: K Shimpo; H Takahashi; H Tsuda; T Hibino; K Kawai; C Kimura; Toshiharu Nagatsu; K Fujita
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Cancer detection and prevention 1996;20(2):137-45.
1996: Toshiharu Nagatsu; Hiroshi Ichinose
Molecular biology of catecholamine neurons in relation to Parkinson's disease.
Advances in neurology 1996;69():147-52.
1995: Toshiharu Nagatsu; Kazuto Kobayashi; H Ichinose
Alterations in catecholamine system enzymes.
Annals of the New York Academy of Sciences 1995;771():159-65.
1995: Nobuyuki Karasawa; Ryohachi Arai; G Isomura; Toshiharu Nagatsu; Ikuko Nagatsu
Chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew (Suncus murinus) are changed by systemic administration of monoamine precursors.
Neuroscience research 1995;24(1):67-74.
1995: Kazuto Kobayashi; S Morita; Hirohide Sawada; T Mizuguchi; K Yamada; I Nagatsu; T Hata; Y Watanabe; K Fujita; Toshiharu Nagatsu
Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice.
The Journal of biological chemistry 1995;270(45):27235-43.
1995: T Suzuki; K Kobayashi; Toshiharu Nagatsu
Genomic structure and tissue distribution of the mouse dopamine D4 receptor.
Neuroscience letters 1995;199(1):69-72.
1995: M Hibiya; R Teradaira; T Sugimoto; K Fujita; Toshiharu Nagatsu
Simultaneous determination of N2-(3-aminopropyl)biopterin (oncopterin), biopterin and neopterin by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Biomedical applications 1995;672(1):143-8.
1995: A Ota; S Yoshida; Toshiharu Nagatsu
Deletion mutagenesis of human tyrosine hydroxylase type 1 regulatory domain.
Biochemical and biophysical research communications 1995;213(3):1099-106.
1995: Hiroshi Ichinose; Tamae Ohye; M Segawa; Y Nomura; K Endo; H Tanaka; S Tsuji; K Fujita; Toshiharu Nagatsu
GTP cyclohydrolase I gene in hereditary progressive dystonia with marked diurnal fluctuation.
Neuroscience letters 1995;196(1-2):5-8.
1995: M Kajita; Toshimitsu Niwa; M Fujisaki; M Ueki; K Niimura; M Sato; K Egami; Makoto Naoi; M Yoshida; Toshiharu Nagatsu
Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical applications 1995;669(2):345-51.
1995: M Mogi; M Harada; T Kondo; H Narabayashi; Peter Riederer; Toshiharu Nagatsu
Transforming growth factor-beta 1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease.
Neuroscience letters 1995;193(2):129-32.
1995: Hiroshi Ichinose; Tamae Ohye; M Yokochi; K Fujita; Toshiharu Nagatsu
GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism.
Neuroscience letters 1995;190(2):140-2.
1995: Hiroshi Ichinose; Tamae Ohye; Y Matsuda; T Hori; N Blau; A Burlina; Bobbye Rouse; R Matalon; K Fujita; Toshiharu Nagatsu
Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.
The Journal of biological chemistry 1995;270(17):10062-71.
1995: Nenad Blau; H Ichinose; Toshiharu Nagatsu; Claus W Heizmann; F Zacchello; A B Burlina
A missense mutation in a patient with guanosine triphosphate cyclohydrolase I deficiency missed in the newborn screening program.
The Journal of pediatrics 1995;126(3):401-5.
1995: T Ohye; H Ichinose; M Ogawa; M Yoshida; Toshiharu Nagatsu
Alterations in multiple tyrosine hydroxylase mRNAs in the substantia nigra, locus coeruleus and adrenal gland of MPTP-treated parkinsonian monkeys.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(1):81-5.
1995: A Ota; H Ichinose; Toshiharu Nagatsu
Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence.
Biochimica et biophysica acta 1995;1260(3):320-2.
1995: Kazuto Kobayashi; S Morita; Hirohide Sawada; T Mizuguchi; K Yamada; I Nagatsu; K Fujita; R J Kreitman; Ira Pastan; Toshiharu Nagatsu
Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1132-6.
1995: Ryohachi Arai; Nobuyuki Karasawa; Toshiharu Nagatsu; Ikuko Nagatsu
Exogenous L-5-hydroxytryptophan is decarboxylated in neurons of the substantia nigra pars compacta and locus coeruleus of the rat.
Brain research 1995;669(1):145-9.
1995: Toshiharu Nagatsu
Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology.
Essays in biochemistry 1995;30():15-35.
1995: Ikuko Nagatsu; H Ichinose; M Sakai; K Titani; M Suzuki; Toshiharu Nagatsu
Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice.
Journal of neural transmission. General section 1995;102(3):175-188.
1995: Takahide Nomura; M Ohtsuki; S Matsui; Chiho Sumi-Ichinose; H Nomura; Yasumichi Hagino; K Iwase; Hiroshi Ichinose; K Fujita; Toshiharu Nagatsu
Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma.
Journal of neural transmission. General section 1995;101(1-3):237-42.
1995: M Mogi; M Harada; T Kondo; Peter Riederer; Toshiharu Nagatsu
Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease.
Journal of neural transmission. Parkinson's disease and dementia section 1995;9(1):87-92.
1994: Ryohachi Arai; Nobuyuki Karasawa; M Geffard; Toshiharu Nagatsu; Ikuko Nagatsu
Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase.
Brain research 1994;667(2):295-9.
1994: Kazuto Kobayashi; S Morita; T Mizuguchi; Hirohide Sawada; K Yamada; I Nagatsu; K Fujita; Toshiharu Nagatsu
Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice.
The Journal of biological chemistry 1994;269(47):29725-31.
1994: Toshiharu Nagatsu; D Nakahara; K Kobayashi; S Morita; H Sawada; T Mizuguchi; K Kiuchi
Peripherally administered (6R)-tetrahydrobiopterin increases in vivo tyrosine hydroxylase activity in the striatum measured by microdialysis both in normal mice and in transgenic mice carrying human tyrosine hydroxylase.
Neuroscience letters 1994;182(1):44-6.
1994: M Mogi; M Harada; T Kondo; Peter Riederer; H Inagaki; M Minami; Toshiharu Nagatsu
Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients.
Neuroscience letters 1994;180(2):147-50.
1994: Nobuyuki Karasawa; Ryohachi Arai; G Isomura; K Yamada; K Sakai; M Sakai; Toshiharu Nagatsu; Ikuko Nagatsu
Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors.
Neuroscience letters 1994;179(1-2):65-70.
1994: S Nasrin; H Ichinose; H Hidaka; Toshiharu Nagatsu
Recombinant human tyrosine hydroxylase types 1-4 show regulatory kinetic properties for the natural (6R)-tetrahydrobiopterin cofactor.
Journal of biochemistry 1994;116(2):393-8.
1994: Mirande Candito; Toshiharu Nagatsu; P Chambon; Marcel Chatel
High-performance liquid chromatographic measurement of cerebrospinal fluid tetrahydrobiopterin, neopterin, homovanillic acid and 5-hydroxindoleacetic acid in neurological diseases.
Journal of chromatography. B, Biomedical applications 1994;657(1):61-6.
1994: M Kajita; Toshimitsu Niwa; Wakako Maruyama; D Nakahara; N Takeda; H Yoshizumi; A Tatematsu; Kazuyoshi Watanabe; Makoto Naoi; Toshiharu Nagatsu
Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine.
Journal of chromatography. B, Biomedical applications 1994;654(2):263-9.
1994: Katsumi Iwase; Akio Nagasaka; I Nagatsu; K Kiuchi; Toshiharu Nagatsu; H Funahashi; T Tsujimura; A Inagaki; Akira Nakai; T Kishikawa
Tyrosine hydroxylase indicates cell differentiation of catecholamine biosynthesis in neuroendocrine tumors.
Journal of endocrinological investigation 1994;17(4):235-9.
1994: Ryohachi Arai; Nobuyuki Karasawa; S Deura; K Kobayashi; Toshiharu Nagatsu; Ikuko Nagatsu
Protein products of the bacterial reporter gene are found within axon terminals in the brain of transgenic mice.
Neuroscience letters 1994;168(1-2):76-80.
1994: A Ota; H Ichinose; K Kobayashi; S Morita; H Sawada; T Mizuguchi; Toshiharu Nagatsu
Nicotine-induced regulation of tyrosine hydroxylase activity in adrenal gland of transgenic mouse carrying human tyrosine hydroxylase gene.
Neuroscience letters 1994;166(1):55-8.
1994: M Mogi; M Harada; Peter Riederer; H Narabayashi; K Fujita; Toshiharu Nagatsu
Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.
Neuroscience letters 1994;165(1-2):208-10.
1994: R Hashimoto; M Mizutani; T Ohta; K Nakazawa; Toshiharu Nagatsu
Changes in plasma tetrahydrobiopterin levels of depressives in depressive and remission phases: reconfirmed by measurement with an internal standard.
Neuropsychobiology 1994;29(2):57-60.
1994: M Mizutani; R Hashimoto; T Ohta; K Nakazawa; Toshiharu Nagatsu
The effect of exercise on plasma biopterin levels.
Neuropsychobiology 1994;29(2):53-6.
1994: Wakako Maruyama; A Ota; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.
Journal of neural transmission. Supplementum 1994;41():327-33.
1994: Makoto Naoi; Wakako Maruyama; T Niwa; Toshiharu Nagatsu
Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin.
Journal of neural transmission. Supplementum 1994;41():197-205.
1994: H Ichinose; T Ohye; K Fujita; F Pantucek; K Lange; Peter Riederer; Toshiharu Nagatsu
Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia.
Journal of neural transmission. Parkinson's disease and dementia section 1994;8(1-2):149-58.
1994: T Nabeshima; A Itoh; K Kobayashi; S Morita; T Mizuguchi; H Sawada; Atsumi Nitta; Takaaki Hasegawa; K Hayashi; Toshiharu Nagatsu
Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene.
Journal of neural transmission. General section 1994;97(1):41-9.
1994: Ikuko Nagatsu; Nobuyuki Karasawa; K Yamada; M Sakai; T Fujii; T Takeuchi; Ryohachi Arai; K Kobayashi; Toshiharu Nagatsu
Expression of human tyrosine hydroxylase-chloramphenicol acetyltransferase (CAT) fusion gene in the brains of transgenic mice as examined by CAT immunocytochemistry.
Journal of neural transmission. General section 1994;96(2):85-104.
1993: Ryohachi Arai; K Yamada; T Fujii; S Deura; K Kobayashi; Toshiharu Nagatsu; Ikuko Nagatsu
Evidence for localization of the transgene product within axon terminals in the dentate gyrus of transgenic mice expressing human phenylethanolamine N-methyltransferase. A light and electron microscopic immunocytochemical study.
Brain research 1993;621(1):141-4.
1993: Hiroshi Ichinose; Tamae Ohye; K Fujita; M Yoshida; S Ueda; Toshiharu Nagatsu
Increased heterogeneity of tyrosine hydroxylase in humans.
Biochemical and biophysical research communications 1993;195(1):158-65.
1993: D Nakahara; H Hashiguti; N Kaneda; T Sasaoka; Toshiharu Nagatsu
Normalization of tyrosine hydroxylase activity in vivo in the striatum of transgenic mice carrying human tyrosine hydroxylase gene: a microdialysis study.
Neuroscience letters 1993;158(1):44-6.
1993: A Ota; W Maruyama; T Takahashi; Makoto Naoi; Toshiharu Nagatsu
The effect of a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), on tyrosine hydroxylase mRNA in PC12h cells.
Neuroscience letters 1993;154(1-2):183-6.
1993: Takahide Nomura; Hiroshi Ichinose; Chiho Sumi-Ichinose; H Nomura; Yasumichi Hagino; K Fujita; Toshiharu Nagatsu
Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I.
Biochemical and biophysical research communications 1993;191(2):523-7.
1993: M Kajita; Toshimitsu Niwa; N Takeda; H Yoshizumi; A Tatematsu; Kazuyoshi Watanabe; Toshiharu Nagatsu
Presence of N-methyldopamine in parkinsonian and normal human brains.
Journal of chromatography 1993;613(1):1-8.
1993: K Kiuchi; K Kiuchi; N Kaneda; T Sasaoka; H Hidaka; Toshiharu Nagatsu
Regulatory mechanism of dopamine biosynthesis in the striatum of transgenic mice carrying human tyrosine hydroxylase gene.
Neuroscience letters 1993;151(1):55-8.
1993: Wakako Maruyama; D Nakahara; P Dostert; H Hashiguchi; S Ohta; M Hirobe; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study.
Neuroscience letters 1993;149(2):115-8.
1993: Kazuto Kobayashi; Toshiharu Nagatsu
[Genetic conversion of neurotransmitter phenotype in transgenic mice].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(1):223-32.
1993: Toshimitsu Niwa; N Takeda; H Yoshizumi; A Tatematsu; M Yoshida; P Dostert; Makoto Naoi; Toshiharu Nagatsu
Presence of tetrahydroisoquinoline-related compounds, possible MPTP-like neurotoxins, in parkinsonian brain.
Advances in neurology 1993;60():234-7.
1993: Makoto Naoi; P Dostert; M Yoshida; Toshiharu Nagatsu
N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins.
Advances in neurology 1993;60():212-7.
1993: S Ogiwara; H Hidaka; T Sugimoto; R Teradaira; K Fujita; Toshiharu Nagatsu
Elevated levels of oncopterin, N2-(3-aminopropyl)biopterin, a new pterin compound, in urine from patients with solid and blood cancers.
Journal of biochemistry 1993;113(1):1-3.
1993: M Minami; Wakako Maruyama; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.
Journal of neural transmission. General section 1993;92(2-3):125-35.
1993: Toshiharu Nagatsu
Enzymatic stimulation and enzymatic inhibition in Parkinson's disease.
Acta neurologica Scandinavica. Supplementum 1993;146():14-7.
1993: Wakako Maruyama; T Takahashi; M Minami; A Takahashi; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines.
Advances in neurology 1993;60():224-30.
1993: M Yoshida; M Ogawa; K Suzuki; Toshiharu Nagatsu
Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues.
Advances in neurology 1993;60():207-11.
1993: Toshiharu Nagatsu
Biochemical aspects of Parkinson's disease.
Advances in neurology 1993;60():165-74.
1992: T Sasaoka; K Kobayashi; I Nagatsu; R Takahashi; M Kimura; M Yokoyama; T Nomura; M Katsuki; Toshiharu Nagatsu
Analysis of the human tyrosine hydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice.
Brain research. Molecular brain research 1992;16(3-4):274-86.
1992: Hiroshi Ichinose; Chiho Sumi-Ichinose; Tamae Ohye; Yasumichi Hagino; K Fujita; Toshiharu Nagatsu
Tissue-specific alternative splicing of the first exon generates two types of mRNAs in human aromatic L-amino acid decarboxylase.
Biochemistry 1992;31(46):11546-50.
1992: S Ogiwara; K Kiuchi; Toshiharu Nagatsu; R Teradaira; I Nagatsu; K Fujita; T Sugimoto
Highly sensitive, specific enzyme-linked immunosorbent assay of neopterin and biopterin in biological samples.
Clinical chemistry 1992;38(10):1954-8.
1992: Toshiharu Nagatsu
[Genes for human catecholamine-synthesizing enzymes: the structure, expression, and pathology].
Yakubutsu, seishin, kōdō = Japanese journal of psychopharmacology 1992;12(5):223-8.
1992: S Ogiwara; Toshiharu Nagatsu; R Teradaira; K Fujita; T Sugimoto
Diastereomers of neopterin and biopterin in human urine.
Biological chemistry Hoppe-Seyler 1992;373(10):1061-5.
1992: Akifumi Togari; H Ichinose; S Matsumoto; K Fujita; Toshiharu Nagatsu
Multiple mRNA forms of human GTP cyclohydrolase I.
Biochemical and biophysical research communications 1992;187(1):359-65.
1992: Wakako Maruyama; D Nakahara; M Ota; T Takahashi; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.
Journal of neurochemistry 1992;59(2):395-400.
1992: Toshimitsu Niwa; Wakako Maruyama; D Nakahara; N Takeda; H Yoshizumi; A Tatematsu; A Takahashi; P Dostert; Makoto Naoi; Toshiharu Nagatsu
Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry.
Journal of chromatography 1992;578(1):109-15.
1992: K Suzuki; Y Mizuno; Y Yamauchi; Toshiharu Nagatsu; Y Mitsuo
Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain.
Journal of the neurological sciences 1992;109(2):219-23.
1992: M Minami; T Takahashi; Wakako Maruyama; A Takahashi; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Inhibition of tyrosine hydroxylase by R and S enantiomers of salsolinol, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline.
Journal of neurochemistry 1992;58(6):2097-101.
1992: D Nakahara; K Fuchikami; N Ozaki; T Iwasaki; Toshiharu Nagatsu
Differential effect of self-stimulation on dopamine release and metabolism in the rat medial frontal cortex, nucleus accumbens and striatum studied by in vivo microdialysis.
Brain research 1992;574(1-2):164-70.
1992: N Iwata; Kazukiyo Kobayashi; T Sasaoka; H Hidaka; Toshiharu Nagatsu
Structure of the mouse tyrosine hydroxylase gene.
Biochemical and biophysical research communications 1992;182(1):348-54.
1992: K Uchida; N Tsuzaki; Toshiharu Nagatsu; Shinichi Kohsaka
Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA.
Developmental neuroscience 1992;14(2):173-80.
1992: M Minami; T Takahashi; Wakako Maruyama; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Allosteric effect of tetrahydrobiopterin cofactors on tyrosine hydroxylase activity.
Life sciences 1992;50(1):15-20.
1992: Toshiharu Nagatsu; Hiroshi Ichinose; S Katoh; K Fujita; K Titani
6R-tetrahydrobiopterin biosynthesis: structures of rat and human sepiapterin reductase.
Journal of nutritional science and vitaminology 1992;Spec No():510-3.
1991: M Sumi; K Kiuchi; T Ishikawa; A Ishii; Masatoshi Hagiwara; Toshiharu Nagatsu; H Hidaka
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.
Biochemical and biophysical research communications 1991;181(3):968-75.
1991: K Shimpo; Toshiharu Nagatsu; K Yamada; T Sato; H Niimi; Mikihiro Shamoto; T Takeuchi; H Umezawa; K Fujita
Ascorbic acid and adriamycin toxicity.
The American journal of clinical nutrition 1991;54(6 Suppl):1298S-1301S.
1991: K Kiuchi; K Kiuchi; K Titani; K Fujita; K Suzuki; Toshiharu Nagatsu
Limited proteolysis of tyrosine hydroxylase by Ca(2+)-activated neutral protease (calpain).
Biochemistry 1991;30(43):10416-9.
1991: Toshiharu Nagatsu
Genes for human catecholamine-synthesizing enzymes.
Neuroscience research 1991;12(2):315-45.
1991: Kazumasa Wakamatsu; Shosuke Ito; Toshiharu Nagatsu
Cysteinyldopamine is not incorporated into neuromelanin.
Neuroscience letters 1991;131(1):57-60.
1991: N Ochi; Kazukiyo Kobayashi; M Maehara; A Nakayama; T Negoro; H Shinohara; Kazuyoshi Watanabe; Toshiharu Nagatsu; K Kato
Increment of alpha B-crystallin mRNA in the brain of patient with infantile type Alexander's disease.
Biochemical and biophysical research communications 1991;179(2):1030-5.
1991: Makoto Naoi; Toshiharu Nagatsu
[Monoamine oxidase inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 1991;49(9):2040-5.
1991: H Ichinose; S Katoh; T Sueoka; K Titani; K Fujita; Toshiharu Nagatsu
Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis.
Biochemical and biophysical research communications 1991;179(1):183-9.
1991: S Ichikawa; S Nasrin; Toshiharu Nagatsu
Expression of mouse tyrosine hydroxylase in Escherichia coli.
Biochemical and biophysical research communications 1991;178(2):664-71.
1991: Toshimitsu Niwa; N Takeda; H Yoshizumi; A Tatematsu; M Yoshida; P Dostert; M Naoi; Toshiharu Nagatsu
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.
Biochemical and biophysical research communications 1991;177(2):603-9.
1991: S Ichikawa; T Sasaoka; Toshiharu Nagatsu
Primary structure of mouse tyrosine hydroxylase deduced from its cDNA.
Biochemical and biophysical research communications 1991;176(3):1610-6.
1991: A Ishii; K Kiuchi; R Kobayashi; M Sumi; H Hidaka; Toshiharu Nagatsu
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Biochemical and biophysical research communications 1991;176(3):1051-6.
1991: Wakako Maruyama; M Minami; A Ota; T Takahashi; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin.
Neuroscience letters 1991;125(1):85-8.
1991: Toshiharu Nagatsu; H Ichinose
Comparative studies on the structure of human tyrosine hydroxylase with those of the enzyme of various mammals.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;98(1):203-10.
1991: N Ochi; M Naoi; M Mogi; Y Ohya; N Mizutani; Kazuyoshi Watanabe; M Harada; Toshiharu Nagatsu
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in prenatal stage on the dopamine system in the postnatal mouse brain.
Life sciences 1991;48(3):217-23.
1990: S Ichikawa; H Ichinose; Toshiharu Nagatsu
Multiple mRNAs of monkey tyrosine hydroxylase.
Biochemical and biophysical research communications 1990;173(3):1331-6.
1990: R Oyama; S Katoh; T Sueoka; M Suzuki; Hiroshi Ichinose; Toshiharu Nagatsu; K Titani
The complete amino acid sequence of the mature form of rat sepiapterin reductase.
Biochemical and biophysical research communications 1990;173(2):627-31.
1990: Ikuko Nagatsu; K Kobayashi; T Fujii; K Komori; K Sekiguchi; K Titani; K Fujita; Toshiharu Nagatsu
Antibodies raised against different oligopeptide segments of human dopamine-beta-hydroxylase.
Neuroscience letters 1990;120(2):141-5.
1990: Toshimitsu Niwa; H Yoshizumi; A Tatematsu; S Matsuura; M Yoshida; M Kawachi; M Naoi; Toshiharu Nagatsu
Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of N-methylisoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline.
Journal of chromatography 1990;533():145-51.
1990: D Nakahara; N Ozaki; Toshiharu Nagatsu
[Microdialysis: a method to construct a microdialysis probe and its applications].
Yakubutsu, seishin, kōdō = Japanese journal of psychopharmacology 1990;10(4):393-9.
1990: M Yoshida; T Niwa; Toshiharu Nagatsu
Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioral and biochemical changes.
Neuroscience letters 1990;119(1):109-13.
1990: K Fujishiro; M Hagihara; A Takahashi; Toshiharu Nagatsu
Concentrations of neopterin and biopterin in the cerebrospinal fluid of patients with Parkinson's disease.
Biochemical medicine and metabolic biology 1990;44(2):97-100.
1990: R Hashimoto; N Ozaki; Tatsuro Ohta; Y Kasahara; N Kaneda; Toshiharu Nagatsu
The plasma tetrahydrobiopterin levels in patients with affective disorders.
Biological psychiatry 1990;28(6):526-8.
1990: M Ota; Makoto Naoi; T Hamanaka; Toshiharu Nagatsu
Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines.
Neuroscience letters 1990;116(3):372-8.
1990: N Alexander; N Kaneda; A Ishii; M Mogi; M Harada; Toshiharu Nagatsu
Right-left asymmetry of tyrosine hydroxylase in rat median eminence: influence of arterial baroreflex nerves.
Brain research 1990;523(2):195-8.
1990: Toshiharu Nagatsu
[Parkinson's disease--the molecular mechanism].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(7 Suppl):1341-52.
1990: M Hagihara; Toshiharu Nagatsu; M Ohhashi; T Miura
Concentrations of neopterin and biopterin in serum from patients with rheumatoid arthritis or systemic lupus erythematosus and in synovial fluid from patients with rheumatoid or osteoarthritis.
Clinical chemistry 1990;36(4):705-6.
1990: Toshiharu Nagatsu
Change of tyrosine hydroxylase in the parkinsonian brain and in the brain of MPTP-treated mice as revealed by homospecific activity.
Neurochemical research 1990;15(4):425-9.
1990: M Hagihara; A Togari; S Matsumoto; Toshiharu Nagatsu
Dietary calcium deprivation increased the levels of plasma catecholamines and catecholamine-synthesizing enzymes of adrenal glands in rats.
Biochemical pharmacology 1990;39(7):1229-31.
1990: Toshiharu Nagatsu
[Brain aging and Parkinson's disease].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1990;27(2):115-22.
1990: K Uchida; A Ishii; N Kaneda; S Toya; Toshiharu Nagatsu; Shinichi Kohsaka
Tetrahydrobiopterin-dependent production of L-dopa in NRK fibroblasts transfected with tyrosine hydroxylase cDNA: future use for intracerebral grafting.
Neuroscience letters 1990;109(3):282-6.
1990: A Ishii; M Hagihara; S Matsuura; K Uchida; K Kiuchi; N Kaneda; S Toya; S Kohsaka; Toshiharu Nagatsu
Effect of (6R)- and (6S)-tetrahydrobiopterin on L-3,4-dihydroxyphenylalanine (DOPA) formation in NRK fibroblasts transfected with human tyrosine hydroxylase type 2 cDNA.
Neurochemistry international 1990;17(4):625-32.
1990: A Ishii; K Kiuchi; M Matsuyama; T Satake; Toshiharu Nagatsu
Ferrous ion activates the less active form of human adrenal tyrosine hydroxylase.
Neurochemistry international 1990;16(1):59-64.
1990: T Kojima; Makoto Naoi; K Wakabayashi; T Sugimura; Toshiharu Nagatsu
3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomes.
Neurochemistry international 1990;16(1):51-7.
1990: Akifumi Togari; S Shintani; M Arai; S Matsumoto; Toshiharu Nagatsu
Acute effect of parathyroid hormone-(1-34) fragment on blood pressure in rats fed a low calcium diet.
General pharmacology 1990;21(4):547-9.
1990: R Hashimoto; N Ozaki; T Ohta; Y Kasahara; N Kaneda; Toshiharu Nagatsu
Plasma tetrahydrobiopterin levels in patients with psychiatric disorders.
Neuropsychobiology 1990;23(3):140-3.
1990: Toshiharu Nagatsu
Changes of tyrosine hydroxylase in parkinsonian brains and in the brains of MPTP-treated mice.
Advances in neurology 1990;53():207-14.
1990: Y Hirata; M Sawada; M Minami; Heii Arai; R Iizuka; Toshiharu Nagatsu
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brain of anorexia nervosa.
Journal of neural transmission. General section 1990;80(2):145-50.
1990: Y Ohya; M Naoi; N Ochi; N Mizutani; Kazuyoshi Watanabe; Toshiharu Nagatsu
Transplacentally-transported 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the catecholamine and indoleamine levels in the fetal mouse brain.
Journal of neural transmission. Parkinson's disease and dementia section 1990;2(4):277-83.
1989: N Ozaki; D Nakahara; H Miura; Y Kasahara; Toshiharu Nagatsu
Effects of apomorphine on in vivo release of dopamine and its metabolites in the prefrontal cortex and the striatum, studied by a microdialysis method.
Journal of neurochemistry 1989;53(6):1861-4.
1989: N Kaneda; Toshiharu Nagatsu
[Pathogenesis of Parkinson's disease, a molecular genetic approach].
Rinshō shinkeigaku = Clinical neurology 1989;29(12):1510-3.
1989: H Ichinose; Yoshikazu Kurosawa; K Titani; K Fujita; Toshiharu Nagatsu
Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase.
Biochemical and biophysical research communications 1989;164(3):1024-30.
1989: M Mogi; M Harada; T Adachi; K Kojima; Toshiharu Nagatsu
Selective removal of beta 2-microglobulin from human plasma by high-performance immunoaffinity chromatography.
Journal of chromatography 1989;496(1):194-200.
1989: Y Ohya; M Naoi; N Ochi; N Mizutani; Kazuyoshi Watanabe; Toshiharu Nagatsu
Uptake of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the N-methyl-4-phenylpyridinium ion (MPP+) into fetal mouse brain through the placenta.
Neuroscience letters 1989;105(1-2):221-6.
1989: D Nakahara; N Ozaki; V Kapoor; Toshiharu Nagatsu
The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: a microdialysis study.
Neuroscience letters 1989;104(1-2):136-40.
1989: M Mogi; M Harada; K Kojima; T Adachi; H Narabayashi; K Fujita; M Naoi; Toshiharu Nagatsu
Beta 2-microglobulin decrease in cerebrospinal fluid from parkinsonian patients.
Neuroscience letters 1989;104(1-2):241-6.
1989: Toshimitsu Niwa; H Yoshizumi; A Tatematsu; S Matsuura; Toshiharu Nagatsu
Presence of tetrahydroisoquinoline, a parkinsonism-related compound, in foods.
Journal of chromatography 1989;493(2):347-52.
1989: Toshiharu Nagatsu
The human tyrosine hydroxylase gene.
Cellular and molecular neurobiology 1989;9(3):313-21.
1989: K Uchida; K Takamatsu; N Kaneda; S Toya; Y Tsukada; Y Kurosawa; K Fujita; Toshiharu Nagatsu; S Kohsaka
Synthesis of L-3,4-dihydroxyphenylalanine by tyrosine hydroxylase cDNA-transfected C6 cells: application for intracerebral grafting.
Journal of neurochemistry 1989;53(3):728-32.
1989: D Nakahara; N Ozaki; Y Miura; H Miura; Toshiharu Nagatsu
Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis.
Brain research 1989;495(1):178-81.
1989: K Maruta; R Teradaira; N Watanabe; Toshiharu Nagatsu; M Asano; K Yamamoto; T Matsumoto; Y Shionoya; K Fujita
Simple, sensitive assay of polyamines by high-performance liquid chromatography with electrochemical detection after post-column reaction with immobilized polyamine oxidase.
Clinical chemistry 1989;35(8):1694-6.
1989: Toshimitsu Niwa; N Takeda; T Sasaoka; N Kaneda; Y Hashizume; H Yoshizumi; A Tatematsu; Toshiharu Nagatsu
Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry.
Journal of chromatography 1989;491(2):397-403.
1989: M Naoi; T Takahashi; H Ichinose; K Wakabayashi; T Sugimura; Toshiharu Nagatsu
Uptake of heterocyclic amines, Trp-P-1 and Trp-P-2, into clonal rat pheochromocytoma PC12h cells by dopamine uptake system.
Neuroscience letters 1989;99(3):317-22.
1989: H Ishiguro; Y Ichihara; T Namikawa; Toshiharu Nagatsu; Yoshikazu Kurosawa
Nucleotide sequence of Suncus murinus immunoglobulin mu gene and comparison with mouse and human mu genes.
FEBS letters 1989;247(2):317-22.
1989: Akifumi Togari; M Arai; T Shamoto; S Matsumoto; Toshiharu Nagatsu
Elevation of blood pressure in young rats fed a low calcium diet. Effects of nifedipine and captopril.
Biochemical pharmacology 1989;38(6):889-93.
1989: K Kobayashi; Yoshikazu Kurosawa; K Fujita; Toshiharu Nagatsu
Human dopamine beta-hydroxylase gene: two mRNA types having different 3'-terminal regions are produced through alternative polyadenylation.
Nucleic acids research 1989;17(3):1089-102.
1989: T Sasaoka; N Kaneda; Yoshikazu Kurosawa; K Fujita; Toshiharu Nagatsu
Structure of human phenylethanolamine n-methyltransferase gene: existence of two types of mRNA with different transcription initiation sites.
Neurochemistry international 1989;15(4):555-65.
1989: Makoto Naoi; T Takahashi; H Parvez; R Kabeya; E Taguchi; K Yamaguchi; Y Hirata; M Minami; Toshiharu Nagatsu
N-methylisoquinolinium ion as an inhibitor of tyrosine hydroxylase, aromatic l-amino acid decarboxylase and monoamine oxidase.
Neurochemistry international 1989;15(3):315-20.
1989: M Hagihara; K Fujishiro; A Takahashi; Makoto Naoi; Toshiharu Nagatsu
Cyclosporin A, an immune suppressor, enhanced neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice.
Neurochemistry international 1989;15(2):249-54.
1989: Toshiharu Nagatsu; S Matsuura; T Sugimoto
Physiological and clinical chemistry of biopterin.
Medicinal research reviews 1989;9(1):25-44.
1989: Toshiharu Nagatsu; K Kiuchi; H Hidaka; K Suzuki
Roles of calcium in the regulation of tyrosine hydroxylase.
Advances in experimental medicine and biology 1989;255():425-33.
1988: M Naoi; T Takahashi; H Ichinose; K Wakabayashi; T Sugimura; Toshiharu Nagatsu
Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines.
Biochemical and biophysical research communications 1988;157(2):494-9.
1988: Ikuko Nagatsu; M Sakai; M Yoshida; Toshiharu Nagatsu
Aromatic L-amino acid decarboxylase-immunoreactive neurons in and around the cerebrospinal fluid-contacting neurons of the central canal do not contain dopamine or serotonin in the mouse and rat spinal cord.
Brain research 1988;475(1):91-102.
1988: Toshimitsu Niwa; N Takeda; A Tatematsu; S Matsuura; M Yoshida; Toshiharu Nagatsu
Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry.
Journal of chromatography 1988;452():85-91.
1988: T Saitoh; Y Mizuno; Toshiharu Nagatsu; M Yoshida
Effect of long-term administration of 1,2,3,4-tetrahydroisoquinoline (TIQ) on striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) content in mice.
Neuroscience letters 1988;92(3):321-4.
1988: K Kobayashi; K Kiuchi; A Ishii; N Kaneda; Yoshikazu Kurosawa; K Fujita; Toshiharu Nagatsu
Expression of four types of human tyrosine hydroxylase in COS cells.
FEBS letters 1988;238(2):431-4.
1988: Toshiharu Nagatsu
[Pathogenic substances in Parkinson disease and new therapeutics considering the etiologic mechanism].
Nihon rinsho. Japanese journal of clinical medicine 1988;46(9):2086-97.
1988: H Ichinose; N Ozaki; D Nakahara; M Naoi; K Wakabayashi; T Sugimura; Toshiharu Nagatsu
Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons.
Biochemical pharmacology 1988;37(17):3289-95.
1988: K Kiuchi; Masatoshi Hagiwara; H Hidaka; Toshiharu Nagatsu
Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells.
Neuroscience letters 1988;89(2):209-15.
1988: T Sasaoka; N Kaneda; Toshimitsu Niwa; Y Hashizume; Toshiharu Nagatsu
Analysis of salsolinol in human brain using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography 1988;428(1):152-5.
1988: N Kaneda; H Ichinose; K Kobayashi; K Oka; F Kishi; A Nakazawa; Yoshikazu Kurosawa; K Fujita; Toshiharu Nagatsu
Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis.
The Journal of biological chemistry 1988;263(16):7672-7.
1988: M Naoi; T Takahashi; Toshiharu Nagatsu
Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation.
Journal of chromatography 1988;427(2):229-38.
1988: Kazukiyo Kobayashi; Norio Kaneda; H Ichinose; F Kishi; A Nakazawa; Yoshikazu Kurosawa; K Fujita; Toshiharu Nagatsu
Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types.
Journal of biochemistry 1988;103(6):907-12.
1988: Toshiharu Nagatsu
[Biochemistry of Parkinson's disease].
Seikagaku. The Journal of Japanese Biochemical Society 1988;60(5):358-66.
1988: M Naoi; T Takahashi; S Ito; K Fujita; Toshiharu Nagatsu
Accumulation of N-methyl-4-phenylpyridinium ion (MPP+) in human melanoma cell line, HMV-I and -II.
Neuroscience letters 1988;87(1-2):57-62.
1988: Toshiharu Nagatsu; M Yoshida
An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.
Neuroscience letters 1988;87(1-2):178-82.
1988: A Togari; H Ichinose; K Kojima; Y Hirata; Toshiharu Nagatsu
Centrally mediated activation of tyrosine hydroxylation in rat adrenals by thyrotropin-releasing hormone.
Biochemical pharmacology 1988;37(8):1637-9.
1988: M Mogi; M Harada; K Kojima; K Kiuchi; Toshiharu Nagatsu
Effects of systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to mice on tyrosine hydroxylase, L-3,4-dihydroxyphenylalanine decarboxylase, dopamine beta-hydroxylase, and monoamine oxidase activities in the striatum and hypothalamus.
Journal of neurochemistry 1988;50(4):1053-6.
1988: N Ozaki; D Nakahara; M Mogi; M Harada; K Kiuchi; N Kaneda; Y Miura; Y Kasahara; Toshiharu Nagatsu
Inactivation of tyrosine hydroxylase in rat striatum by 1-methyl-4-phenylpyridinium ion (MPP+).
Neuroscience letters 1988;85(2):228-32.
1988: N Alexander; D Nakahara; N Ozaki; N Kaneda; T Sasaoka; N Iwata; Toshiharu Nagatsu
Striatal dopamine release and metabolism in sinoaortic-denervated rats by in vivo microdialysis.
The American journal of physiology 1988;254(2 Pt 2):R396-9.
1988: Makoto Naoi; T Iwashita; Toshiharu Nagatsu
Uptake of glycosylated ?-galactosidase into human brain synaptosomes: Occurrence of two different systems for specific glycosides.
Neurochemistry international 1988;13(1):75-9.
1988: M Mogi; M Harada; K Kojima; H Inagaki; T Kondo; H Narabayashi; T Arai; R Teradaira; K Fujita; K Kiuchi; Toshiharu Nagatsu
Sandwich enzyme immunoassay of dopamine-?-hydroxylase in cerebrospinal fluid from control and parkinsonian patients.
Neurochemistry international 1988;12(2):187-91.
1988: R Hashimoto; N Ozaki; Tatsuro Ohta; Y Kasahara; N Kaneda; Toshiharu Nagatsu
Plasma biopterin levels of patients with affective disorders.
Neuropsychobiology 1988;19(2):61-3.
1988: M Naoi; T Takahashi; Toshiharu Nagatsu
Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on catecholamine levels and activity of related enzymes in clonal rat pheochromocytoma PC12h cells.
Life sciences 1988;43(18):1485-91.
1988: M Mogi; M Harada; K Kiuchi; K Kojima; T Kondo; H Narabayashi; D Rausch; Peter Riederer; Kurt A Jellinger; Toshiharu Nagatsu
Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain.
Journal of neural transmission 1988;72(1):77-82.
1988: K Kiuchi; Y Hirata; M Minami; Toshiharu Nagatsu
Effect of 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)- 2(1H)-quinolinone (OPC-4392), a newly synthesized agonist for presynaptic dopamine D2 receptor, on tyrosine hydroxylation in rat striatal slices.
Life sciences 1988;42(3):343-9.
1988: Wolf-Dieter Rausch; Y Hirata; Toshiharu Nagatsu; Peter Riederer; Kurt A Jellinger
Tyrosine hydroxylase activity in caudate nucleus from Parkinson's disease: effects of iron and phosphorylating agents.
Journal of neurochemistry 1988;50(1):202-8.
1987: M Sawada; Y Hirata; M Minami; Toshiharu Nagatsu
Effects of thyrotropin releasing hormone and its analogue, DN 1417, on biopterin concentration and tryptophan hydroxylation in rat raphe slices.
Life sciences 1987;41(25):2733-7.
1987: M Hagihara; Toshiharu Nagatsu
Post-proline cleaving enzyme in human cerebrospinal fluid from control patients and parkinsonian patients.
Biochemical medicine and metabolic biology 1987;38(3):387-91.
1987: K Kiuchi; K Kiuchi; A Togari; Toshiharu Nagatsu
Effect of spermine on tyrosine hydroxylase activity before and after phosphorylation by cyclic AMP-dependent protein kinase.
Biochemical and biophysical research communications 1987;148(3):1460-7.
1987: Shinichi Koizumi; T Suzuki; S Takahashi; K Satake; T Takeuchi; H Umezawa; Toshiharu Nagatsu
Sulfhydryl modification and activation of phenylalanine hydroxylase by dinitrophenyl alkyl disulfide.
Biochemistry 1987;26(20):6461-5.
1987: M Mogi; M Harada; K Kojima; K Kiuchi; I Nagatsu; Toshiharu Nagatsu
Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase activity in vitro and tyrosine hydroxylase content.
Neuroscience letters 1987;80(2):213-8.
1987: Toshiharu Nagatsu; M Sawada; S Matsuura; T Sugimoto
[Polarization fluoroimmunoassay of biopterin and neopterin].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1987;(31 Suppl):280-5.
1987: H Ichinose; A Togari; H Suzuki; H Kumagai; Toshiharu Nagatsu
Increase of catecholamines in mouse brain by systemic administration of gamma-glutamyl L-3,4-dihydroxyphenylalanine.
Journal of neurochemistry 1987;49(3):928-32.
1987: K Kobayashi; N Kaneda; H Ichinose; F Kishi; A Nakazawa; Y Kurosawa; K Fujita; Toshiharu Nagatsu
Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3.
Nucleic acids research 1987;15(16):6733.
1987: N Kaneda; K Kobayashi; H Ichinose; F Kishi; A Nakazawa; Y Kurosawa; K Fujita; Toshiharu Nagatsu
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
Biochemical and biophysical research communications 1987;146(3):971-5.
1987: M Hagihara; R Mihara; A Togari; Toshiharu Nagatsu
Dipeptidyl-aminopeptidase II in human cerebrospinal fluid: changes in patients with Parkinson's disease.
Biochemical medicine and metabolic biology 1987;37(3):360-5.
1987: M Naoi; H Suzuki; K Kiuchi; T Takahashi; Toshiharu Nagatsu
Effect of N-methyl-4-phenylpyridinium ion on monoamine oxidase in a clonal rat pheochromocytoma cell line, PC12h.
Journal of neurochemistry 1987;48(6):1912-6.
1987: T Niwa; N Takeda; N Kaneda; Y Hashizume; Toshiharu Nagatsu
Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.
Biochemical and biophysical research communications 1987;144(2):1084-9.
1987: Toshiharu Nagatsu; H Suzuki; K Kiuchi; M Saitoh; H Hidaka
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells.
Biochemical and biophysical research communications 1987;143(3):1045-8.
1987: M Sawada; Y Hirata; Heii Arai; R Iizuka; Toshiharu Nagatsu
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of Alzheimer type.
Journal of neurochemistry 1987;48(3):760-4.
1987: Toshiharu Nagatsu
MPTP and its relevance to parkinson's disease.
Neurochemistry international 1987;11(4):375-7.
1987: T Takahashi; Makoto Naoi; Toshiharu Nagatsu
Uptake of N-methyl-4-phenylpyridinium ion (MPP(+)) into PC12h pheochromocytoma cells.
Neurochemistry international 1987;11(1):89-93.
1987: Toshiharu Nagatsu; T Horikoshi; M Sawada; I Nagatsu; T Kondo; R Iizuka; H Narabayashi
Biosynthesis of tetrahydrobiopterin in parkinsonian human brain.
Advances in neurology 1987;45():223-6.
1987: T Kondo; H Narabayashi; Toshiharu Nagatsu; T Yamaguchi; M Sawada
Effects of tyrosine administration on plasma biopterin in patients with juvenile parkinsonism and their relatives.
Advances in neurology 1987;45():217-22.
1987: Christine Konradi; Kurt A Jellinger; Peter Riederer; Toshiharu Nagatsu
Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil.
Journal of neural transmission 1987;70(3-4):369-76.
1987: N Ozaki; D Nakahara; N Kaneda; K Kiuchi; T Okada; Y Kasahara; Toshiharu Nagatsu
Acute effects of 1-methyl-4-phenylpyridinium ion (MPP+) on dopamine and serotonin metabolism in rat striatum as assayed in vivo by a micro-dialysis technique.
Journal of neural transmission 1987;70(3-4):241-50.
1987: R Hashimoto; N Ozaki; Tatsuro Ohta; Y Kasahara; N Kaneda; Toshiharu Nagatsu
Total biopterin levels of plasma in patients with depression.
Neuropsychobiology 1987;17(4):176-7.
1987: H Narabayashi; T Kondo; F Yokochi; Toshiharu Nagatsu
Clinical effects of L-threo-3,4-dihydroxyphenylserine in cases of parkinsonism and pure akinesia.
Advances in neurology 1987;45():593-602.
1987: Toshiharu Nagatsu; K Oka
Tyrosine 3-monooxygenase from bovine adrenal medulla.
Methods in enzymology 1987;142():56-62.
1987: Toshiharu Nagatsu; Y Hirata
Inhibition of the tyrosine hydroxylase system by MPTP, 1-methyl-4-phenylpyridinium ion (MPP+) and the structurally related compounds in vitro and in vivo.
European neurology 1987;26 Suppl 1():11-5.
1986: M Sawada; T Sugimoto; S Matsuura; Toshiharu Nagatsu
(6R)-tetrahydrobiopterin increases the activity of tryptophan hydroxylase in rat raphe slices.
Journal of neurochemistry 1986;47(5):1544-7.
1986: Y Hirata; Toshiharu Nagatsu
Early and late effects of systemically administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on tyrosine hydroxylase activity in vitro and on tyrosine hydroxylation in tissue slices of mouse striatum.
Neuroscience letters 1986;68(2):245-8.
1986: N Kaneda; M Asano; Toshiharu Nagatsu
Simple method for the simultaneous determination of acetylcholine, choline, noradrenaline, dopamine and serotonin in brain tissue by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography 1986;360(1):211-8.
1986: M Sawada; T Horikoshi; M Masada; M Akino; T Sugimoto; S Matsuura; Toshiharu Nagatsu
A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin.
Analytical biochemistry 1986;154(1):361-6.
1986: Y Hirata; Toshiharu Nagatsu
[Mechanism of induction of parkinsonism by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a dopaminergic neurotoxin].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1986;31(5):398-409.
1986: A Togari; S Ichikawa; Toshiharu Nagatsu
Activation of tyrosine hydroxylase by Ca2+-dependent neutral protease, calpain.
Biochemical and biophysical research communications 1986;134(2):749-54.
1985: A Togari; K Kojima; Toshiharu Nagatsu
Molecular and physiological properties of tyrosine hydroxylase induced by reserpine in rat adrenal gland.
Life sciences 1985;37(17):1605-11.
1985: I Nagatsu; M Ito; Y Kawakami; N Karasawa; H Takahashi; K Fujita; Toshiharu Nagatsu
Quantitative immunofluorescence of tyrosine hydroxylase in the adrenal medulla of spontaneously hypertensive rats.
Experientia 1985;41(8):1054-5.
1985: Y Hirata; Toshiharu Nagatsu
Evidence for the involvement of Ca2+-calmodulin and cyclic AMP in the regulation of the tyrosine hydroxylase system in rat striatal tissue slices.
Biochemical pharmacology 1985;34(15):2637-43.
1985: Y Hirata; Toshiharu Nagatsu
Inhibition of tyrosine hydroxylation in tissue slices of the rat striatum by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Brain research 1985;337(1):193-6.
1985: M Sawada; Toshiharu Nagatsu; I Nagatsu; K Ito; R Iizuka; T Kondo; H Narabayashi
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Journal of neural transmission 1985;62(1-2):107-15.
1984: Toshiharu Nagatsu
[Parkinson's disease].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1984;29(14):1801-14.
1984: Shinichi Koizumi; Y Matsushima; Toshiharu Nagatsu; H Iinuma; T Takeuchi; H Umezawa
3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases.
Biochimica et biophysica acta 1984;789(2):111-8.
1984: Toshiharu Nagatsu; M Sawada; T Yamaguchi; T Sugimoto; S Matsuura; M Akino; N Nakazawa; H Ogawa
Radioimmunoassay for neopterin in body fluids and tissues.
Analytical biochemistry 1984;141(2):472-80.
1984: N Alexander; Y Hirata; Toshiharu Nagatsu
Reduced tyrosine hydroxylase activity in nigrostriatal system of sinoaortic-denervated rats.
Brain research 1984;299(2):380-2.
1984: M Sawada; T Yamaguchi; T Sugimoto; S Matsuura; Toshiharu Nagatsu
Polarization fluoroimmunoassay of biopterin and neopterin in human urine.
Clinica chimica acta; international journal of clinical chemistry 1984;138(3):275-82.
1984: H Matsui; N Kato; C Yamamoto; K Fujita; H Sakai; Toshiharu Nagatsu
A sensitive fluorometric assay for dopamine-beta-hydroxylase activity by high-performance liquid chromatography.
Biochemical medicine 1984;31(2):140-6.
1984: Toshiharu Nagatsu; K Fujita; K Kawai; K Shinpo; M Shinzato
[Schizophrenia and neurotransmitters].
Nihon rinsho. Japanese journal of clinical medicine 1984;42(4):891-901.
1984: M Mogi; K Kojima; Toshiharu Nagatsu
Detection of inactive or less active forms of tyrosine hydroxylase in human adrenals by a sandwich enzyme immunoassay.
Analytical biochemistry 1984;138(1):125-32.
1984: H Narabayashi; T Kondo; Toshiharu Nagatsu; A Hayashi; T Suzuki
DL-threo-3,4-dihydroxyphenylserine for freezing symptom in parkinsonism.
Advances in neurology 1984;40():497-502.
1984: Toshiharu Nagatsu; T Yamaguchi; M K Rahman; J Trocewicz; K Oka; Y Hirata; I Nagatsu; H Narabayashi; T Kondo; R Iizuka
Catecholamine-related enzymes and the biopterin cofactor in Parkinson's disease and related extrapyramidal diseases.
Advances in neurology 1984;40():467-73.
1984: M Yokochi; H Narabayashi; R Iizuka; Toshiharu Nagatsu
Juvenile parkinsonism--some clinical, pharmacological, and neuropathological aspects.
Advances in neurology 1984;40():407-13.
1983: K Oka; K Kojima; Toshiharu Nagatsu
Characterization of tyrosine hydroxylase from bovine adrenal medulla.
Biochemistry international 1983;7(3):387-93.
1983: A Togari; H Kano; K Oka; Toshiharu Nagatsu
Simultaneous simple purification of tyrosine hydroxylase and dihydropteridine reductase.
Analytical biochemistry 1983;132(1):183-9.
1983: K Shinpo; K Fujita; K Maruta; R Teradaira; Toshiharu Nagatsu
Comparative measurements of urinary polyamines in early morning and 24-hour urine specimens.
Clinica chimica acta; international journal of clinical chemistry 1983;131(1-2):143-8.
1983: Y Hirata; A Togari; Toshiharu Nagatsu
Studies on tyrosine hydroxylase system in rat brain slices using high-performance liquid chromatography with electrochemical detection.
Journal of neurochemistry 1983;40(6):1585-9.
1983: T Yamaguchi; Toshiharu Nagatsu; T Sugimoto; S Matsuura; T Kondo; R Iizuka; H Narabayashi
Effects of tyrosine administration on serum biopterin in normal controls and patients with Parkinson's disease.
Science (New York, N.Y.) 1983;219(4580):75-7.
1983: Y Kondo; I Nagatsu; M Yoshida; N Karasawa; Toshiharu Nagatsu
Existence of noradrenalin cells and serotonin cells in the pituitary gland of Rana catesbeiana.
Cell and tissue research 1983;228(2):405-8.
1982: K Fujita; R Teradaira; T Inoue; H Takahashi; H Beppu; K Kawai; K Maruta; S Yagyu; Toshiharu Nagatsu
Stress-induced changes in in vivo and in vitro dopamine-beta-hydroxylase activity in spontaneously hypertensive rats.
Biochemical medicine 1982;28(3):340-6.
1982: M Yoshida; I Nagatsu; Y Kondo; N Karasawa; T Ohno; M Spatz; Toshiharu Nagatsu
Two cell types in monoamine-containing "liquor contacting' neuron system of the frog brain.
Experientia 1982;38(9):1097-9.
1982: K Oka; G Ashiba; T Sugimoto; S Matsuura; Toshiharu Nagatsu
Kinetic properties of tyrosine hydroxylase purified from bovine adrenal medulla and bovine caudate nucleus.
Biochimica et biophysica acta 1982;706(2):188-96.
1982: J Trocewicz; K Oka; Toshiharu Nagatsu; I Nagatsu; R Iizuka; H Narabayashi
Phenylethanolamine N-methyltransferase activity in human brains.
Biochemical medicine 1982;27(3):317-24.
1982: K Fujita; K Maruta; R Teradaira; H Beppu; M Ikegame; K Kawai; Toshiharu Nagatsu
Dopamine beta-hydroxylase activity in human cerebrospinal fluid from various age groups.
Clinical chemistry 1982;28(6):1403-4.
1982: A Togari; T Kato; Toshiharu Nagatsu
Studies on the regulatory mechanism of the tyrosine hydroxylase system in adrenal slices by using high-performance liquid chromatography with electrochemical detection.
Biochemical pharmacology 1982;31(9):1729-34.
1982: K Oka; M Sekiya; H Osada; K Fujita; T Kato; Toshiharu Nagatsu
Simultaneous fluorometry of urinary dopamine, norepinephrine, and epinephrine compared with liquid chromatography with electrochemical detection.
Clinical chemistry 1982;28(4 Pt 1):646-9.
1982: T Kato; T Yamaguchi; A Togari; Toshiharu Nagatsu; T Yajima; N Maeda; M Kumegawa
Ontogenesis of monoamine-synthesizing enzyme activities and biopterin levels in rat brain or salivary glands, and the effects of thyroxine administration.
Journal of neurochemistry 1982;38(4):896-901.
1981: K Oka; T Kato; T Sugimoto; S Matsuura; Toshiharu Nagatsu
Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor.
Biochimica et biophysica acta 1981;661(1):45-53.
1981: H Matsui; T Kato; C Yamamoto; K Fujita; Toshiharu Nagatsu
Highly sensitive assay for dopamine-beta-hydroxylase activity in human cerebrospinal fluid by high performance liquid chromatography-electrochemical detection: properties of the enzyme.
Journal of neurochemistry 1981;37(2):289-96.
1981: Toshiharu Nagatsu
[Abnormalities of catecholamine metabolism in Parkinson's disease (author's transl)].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1981;26(11):1781-8.
1981: Toshiharu Nagatsu; T Yamaguchi; T Kato; T Sugimoto; S Matsuura; M Akino; I Nagatsu; R Iizuka; H Narabayashi
Biopterin in human brain and urine from controls and parkinsonian patients: application of a new radioimmunoassay.
Clinica chimica acta; international journal of clinical chemistry 1981;109(3):305-11.
1981: Toshiharu Nagatsu; T Yamaguchi; T Kato; T Sugimoto; S Matsuura; M Akino; S Tsushima; N Nakazawa; H Ogawa
Radioimmunoassay for biopterin in body fluids and tissues.
Analytical biochemistry 1981;110(1):182-9.
1981: T Kato; S Horiuchi; A Togari; Toshiharu Nagatsu
A sensitive and inexpensive high-performance liquid chromatographic assay for tyrosine hydroxylase.
Experientia 1981;37(8):809-11.
1981: Kenji Kosaka; R Iizuka; Y Mizutani; T Kondo; Toshiharu Nagatsu
Striatonigral degeneration combined with Alzheimer's disease.
Acta neuropathologica 1981;54(3):253-6.
1980: K Fujita; Toshiharu Nagatsu; K Shinpo; K Maruta; R Teradaira; M Nakamura
Improved analysis for urinary polyamines by use of high-voltage electrophoresis on paper.
Clinical chemistry 1980;26(11):1577-82.
1980: K Oka; T Kato; T Takita; T Takeuchi; H Umezawa; Toshiharu Nagatsu
Inhibition of tyrosine hydroxylase, a Fe(II)-stimulated monooxygenase, by bleomycin.
The Journal of antibiotics 1980;33(9):1043-7.
1980: T Kato; K Oka; Toshiharu Nagatsu; T Sugimoto; S Matsuura
Effects of structures of tetrahydropterin cofactors on tyrosine hydroxylase.
Biochimica et biophysica acta 1980;612(1):226-32.
1980: T Kato; T Yamaguchi; Toshiharu Nagatsu; T Sugimoto; S Matsuura
Effects of structures of tetrahydropterin cofactors on rat brain tryptophan hydroxylase.
Biochimica et biophysica acta 1980;611(2):241-50.
1979: Toshiharu Nagatsu; T Yamamoto; T Kato
A new and highly sensitive voltammetric assay for aromatic L-amino acid decarboxylase activity by high-performance liquid chromatography.
Analytical biochemistry 1979;100(1):160-5.
1979: Toshiharu Nagatsu; K Oka; T Kato
Highly sensitive assay for tyrosine hydroxylase activity by high-performance liquid chromatography.
Journal of chromatography 1979;163(3):247-52.
1979: I Nagatsu; Y Kondo; S Inagaki; H Kojima; Toshiharu Nagatsu
Immunofluorescent and biochemical studies on tyrosine hydroxylase and dopamine-beta-hydroxylase of the bullfrog sciatic nerves.
Histochemistry 1979;61(2):103-9.
1979: T Kato; Toshiharu Nagatsu; R Iizuka; H Narabayashi
Cyclic AMP-dependent protein kinase activity in the human brain: values in Parkinsonism.
Biochemical medicine 1979;21(2):141-5.
1979: Toshiharu Nagatsu; K Oka; Y Numata(Sudo); T Kato
A simple and sensitive fluorescence assay for tyrosine hydroxylase activity.
Analytical biochemistry 1979;93(1):82-7.
1978: Toshiharu Nagatsu; T Kanamori; T Kato; R Iizuka; H Narabayashi
Dopamine-stimulated adenylate cyclase activity in the human brain: changes in Parkinsonism.
Biochemical medicine 1978;19(3):360-5.
1978: Toshiharu Nagatsu; Y Numata(Sudo); T Kato; K Sugiyama; M Akino
Effects of melanin on tyrosine hydroxylase and phenylalanine hydroxylase.
Biochimica et biophysica acta 1978;523(1):47-52.
1977: Toshiharu Nagatsu; T Kato; Y Numata(sudo); K Ikuta; M Sano
Norepinephrine-synthesizing enzymes in brain, adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats.
Japanese journal of pharmacology 1977;27(4):531-5.
1977: Toshiharu Nagatsu; T Kato; Y Numata; K Ikuta; M Sano
Noradrenaline-synthesizing enzymes in brain, serum, sympathetically innervated tissues, and adrenals of spontaneously hypertensive rats [proceedings].
Japanese heart journal 1977;18(4):583.
1977: Toshiharu Nagatsu; T Kato; Y Numata; K Ikuta; M Sano; I Nagatsu; T Takeuchi; M Matsuzaki; H Umezawa
Correlation between serum dopamine-beta-hydroxylase activity and dopamine-beta-hydroxylase and tyrosine hydroxylase activities in central and peripheral adrenergic neurons and adrenal glands.
Experientia 1977;33(5):581-3.
1977: Toshiharu Nagatsu; T Kato; Y Numata; K Ikuta; M Sano
Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain.
Clinica chimica acta; international journal of clinical chemistry 1977;75(2):221-32.
1977: Y Numata; T Kato; Toshiharu Nagatsu; T Sugimoto; S Matsuura
Effects of stereochemical structures of tetrahydrobiopterin on tyrosine hydroxylase.
Biochimica et biophysica acta 1977;480(1):104-12.
1977: Toshiharu Nagatsu
[Induction of the enzymes related to neurogenic amines (author's transl)].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1977;22(6):530-4.
1976: S Hosoda; H Suzuki; T Oguri; K Ikuta; Toshiharu Nagatsu
Adrenal pheochromocytoma with both benign and malignant components.
Acta pathologica japonica 1976;26(4):519-31.
1976: Toshiharu Nagatsu
[Tyrosine hydroxylase (author's transl)].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1976;21(3):161-73.
1976: Toshiharu Nagatsu; K Ikuta; Y Numata; T Kato; M Sano
Vascular and brain dopamine beta-hydroxylase activity in young spontaneously hypertensive rats.
Science (New York, N.Y.) 1976;191(4224):290-1.
1975: Y Numata; K Ikuta; T Kato; Toshiharu Nagatsu; T Sugimoto; S Matsuura
Effects of stereochemical structures of tetrahydropterins on tyrosine hydroxylase.
Biochemical pharmacology 1975;24(21):1998-2000.
1975: Toshiharu Nagatsu; T Kato; Y Numata; K Ikuta; H Kuzuya
Dopamine beta-hydroxylase and tyrosine hydroxylase activities in spontaneously hypertensive rats after NaCl administration.
Experientia 1975;31(7):767-8.
1975: Y Numata; Toshiharu Nagatsu
Properties of tyrosine hydroxylase in peripheral nerves.
Journal of neurochemistry 1975;24(2):317-22.
1973: H Kuzuya; K Ikuta; Toshiharu Nagatsu
Inhibition of dopamine-beta-hydroxylase by spinochrome A and echinochrome A, naphthoquinone pigments of echinoids.
Biochemical pharmacology 1973;22(21):2722-4.
1973: Toshiharu Nagatsu; K Mizutani; I Nagatsu; H Umezawa; M Matsuzaki
Catecholamine synthetic enzymes of spontaneously hypertensive rats and microbial hypotensive products.
Molecular and cellular biochemistry 1973;1(1):107-13.
1973: V Dequattro; Toshiharu Nagatsu; A Mendez; J Verska
Determinants of cardiac noradrenaline depletion in human congestive failure.
Cardiovascular research 1973;7(3):344-50.
1972: K Mizutani; Toshiharu Nagatsu; M Asashima; S Kinoshita
Inhibition of tyrosine hydroxylase by naphthoquinone pigments of echinoids.
Biochemical pharmacology 1972;21(18):2463-8.
1972: I Nagatsu; Y Sudo; Toshiharu Nagatsu
Tyrosine hydroxylation in the banana plant.
Enzymologia 1972;43(1):25-31.
1972: Toshiharu Nagatsu; K Mizutani; I Nagatsu; S Matsuura; T Sugimoto
Pteridines as cofactor or inhibitor of tyrosine hydroxylase.
Biochemical pharmacology 1972;21(14):1945-53.
1972: Toshiharu Nagatsu; K Mizutani; Y Sudo; I Nagatsu
Tyrosine hydroxylase in human adrenal glands and human pheochromocytoma.
Clinica chimica acta; international journal of clinical chemistry 1972;39(2):417-24.
1971: Toshiharu Nagatsu; Y Sudo; I Nagatsu
Tyrosine hydroxylase in bovine caudate nucleus.
Journal of neurochemistry 1971;18(11):2179-89.
1971: Toshiharu Nagatsu; I Nagatsu; H Umezawa; T Takeuchi
Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations.
Biochemical pharmacology 1971;20(9):2505-7.
1971: I Nagatsu; Toshiharu Nagatsu; K Mizutani; H Umezawa; M Matsuzaki; T Takeuchi
Adrenal tyrosine hydroxylase and dopamine beta-hydroxylase in spontaneously hypertensive rats.
Nature 1971;230(5293):381-2.
1970: Toshiharu Nagatsu; T Yamamoto; I Nagatsu
Partial separation and properties of tyrosine hydroxylase from the human pheochromocytoma: effect of norepinephrine.
Biochimica et biophysica acta 1970;198(2):210-8.
1970: Toshiharu Nagatsu; H Hidaka; H Kuzuya; K Takeya; H Umezawa
Inhibition of dopamine beta-hydroxylase by fusaric acid (5-butylpicolinic acid) in vitro and in vivo.
Biochemical pharmacology 1970;19(1):35-44.
1969: H Suda; T Takeuchi; Toshiharu Nagatsu; M Matsuzaki; I Matsumoto; H Umezawa
Inhibition of dopamine beta-hydroxylase by 5-alkylpicolinic acid and their hypotensive effects.
Chemical & pharmaceutical bulletin 1969;17(11):2377-80.
1969: H Hidaka; Toshiharu Nagatsu; K Takeya; T Takeuchi; H Suda
Fusaric acid, a hypotensive agent produced by fungi.
The Journal of antibiotics 1969;22(5):228-30.
1969: H Kuzuya; Toshiharu Nagatsu
A simple assay of dopamine beta-hydroxylase activity in the homogenate of the adrenal medulla.
Enzymologia 1969;36(1):31-8.
1968: Toshiharu Nagatsu; J B van der Schoot; M Levitt; S Udenfriend
Factors influencing dopamine beta-hydroxylase activity and epinephrine levels in guinea pig adrenal gland.
Journal of biochemistry 1968;64(1):39-43.
1968: Toshiharu Nagatsu; S Ayukawa; H Umezawa
Inhibition of dopamine beta-hydroxylase by aquayamycin.
The Journal of antibiotics 1968;21(5):354-7.
1967: Toshiharu Nagatsu; H Kuzuya; H Hidaka
Inhibition of dopamine beta-hydroxylase by sulfhydryl compounds and the nature of the natural inhibitors.
Biochimica et biophysica acta 1967;139(2):319-27.
1964: Toshiharu Nagatsu; M LEVITT; S UDENFRIEND
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
The Journal of biological chemistry 1964;239():2910-7.
1963: J VAN DER SCHOOT; C R CREVELING; Toshiharu Nagatsu; S UDENFRIEND
On the mechanism of inhibition of dopamine-beta-oxidase by benzyloxyamines.
The Journal of pharmacology and experimental therapeutics 1963;141():74-8.