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Lex Nagelkerken

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Rob Mariman; Frits Koning; Bas Kremer; Tonny Lagerweij; Marjan van Erk; Lex Nagelkerken
Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics.
Bas Kremer; Tonny Lagerweij; Rob Mariman; Marjan van Erk; Lex Nagelkerken
Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes.
Fumio Tsuji; Masaaki Murai; Kenji Oki; Iwao Seki; Kenji Ueda; Hiroyuki Inoue; Lex Nagelkerken; Minoru Sasano; Hiroyuki Aono
Transient receptor potential vanilloid 1 agonists as candidates for anti-inflammatory and immunomodulatory agents.

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All Publications

2012: Rob Mariman; Frits Koning; Bas Kremer; Tonny Lagerweij; Marjan van Erk; Lex Nagelkerken
Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics.
Inflammatory bowel diseases 2012;18(8):1424-33.
2012: Bas Kremer; Tonny Lagerweij; Rob Mariman; Marjan van Erk; Lex Nagelkerken
Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes.
PloS one 2012;7(11):e50388.
2010: Fumio Tsuji; Masaaki Murai; Kenji Oki; Iwao Seki; Kenji Ueda; Hiroyuki Inoue; Lex Nagelkerken; Minoru Sasano; Hiroyuki Aono
Transient receptor potential vanilloid 1 agonists as candidates for anti-inflammatory and immunomodulatory agents.
European journal of pharmacology 2010;627(1-3):332-9.
2008: Junda M Kel; Bram Slütter; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells.
Journal of leukocyte biology 2008;84(1):182-90.
2008: Lex Nagelkerken; Perry Verzaal; Tonny Lagerweij; Carla Persoon-Deen; Jimmy F P Berbee; Errol P Prens; Louis M Havekes; Arnold P Oranje
Development of atopic dermatitis in mice transgenic for human apolipoprotein C1.
The Journal of investigative dermatology 2008;128(5):1165-72.
2008: Junda M Kel; Eveline De Geus; Marianne J van Stipdonk; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation.
International immunology 2008;20(1):117-27.
2007: A O Kraaijeveld; Saskia C A de Jager; Wilco de Jager; B J Prakken; S R McColl; Inge Haspels; Hein Putter; Theo Van berkel; Lex Nagelkerken; J Wouter Jukema; Erik A L Biessen
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.
Circulation 2007;116(17):1931-41.
2007: Junda M Kel; Judith Oldenampsen; Mariken E Luca; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis.
The American journal of pathology 2007;170(1):272-80.
2006: Luba Lopatinskaya; J Zwemmer; Bernard Uitdehaag; K Lucas; Chris H Polman; Lex Nagelkerken
Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years.
Multiple sclerosis (Houndmills, Basingstoke, England) 2006;12(6):704-9.
2005: Peter Rieckmann; N Kruse; Lex Nagelkerken; Karola Beckmann; D Miller; Chris H Polman; Frank Dahlke; K V Toyka; H P Hartung; S Stürzebecher
Soluble vascular cell adhesion molecule (VCAM) is associated with treatment effects of interferon beta-1b in patients with secondary progressive multiple sclerosis.
Journal of neurology 2005;252(5):526-33.
2005: Mariken E Luca; Junda M Kel; Wouter Van Rijs; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Mannosylated PLP(139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2005;160(1-2):178-87.
2004: Mario H J Vogt; Sarah Floris; Joep Killestein; Dirk L Knol; Monique Smits; Frederik Barkhof; Chris H Polman; Lex Nagelkerken
Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients.
Journal of neuroimmunology 2004;155(1-2):155-60.
2004: Lex Nagelkerken; Inge Haspels; Wouter Van Rijs; Bep Blauw; Janine L Ferrant; Donna M Hess; Ellen A Garber; Frederick R Taylor; Linda C Burkly
FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):993-9.
2003: Mario H J Vogt; Luba Lopatinskaya; Monique Smits; Chris H Polman; Lex Nagelkerken
Elevated osteopontin levels in active relapsing-remitting multiple sclerosis.
Annals of neurology 2003;53(6):819-22.
2003: Luba Lopatinskaya; Anette H H van Boxel-Dezaire; Frederik Barkhof; Chris H Polman; Cornelis J Lucas; Lex Nagelkerken
The development of clinical activity in relapsing-remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood.
Journal of neuroimmunology 2003;138(1-2):123-31.
2003: Joep Killestein; E L J Hoogervorst; Marcus Reif; Bep Blauw; Monique Smits; Bernard Uitdehaag; Lex Nagelkerken; Chris H Polman
Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis.
Journal of neuroimmunology 2003;137(1-2):140-3.
2002: Jeroen Visser; Lex Nagelkerken
Expression of the IL-10 receptor on human monocytes is moderately suppressed by glucocorticoids.
International immunopharmacology 2002;2(10):1491-3.
2001: Anette H H van Boxel-Dezaire; Monique Smits; S C van Trigt-Hoff; Joep Killestein; Johannes C van Houwelingen; Chris H Polman; Lex Nagelkerken
Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis.
Journal of neuroimmunology 2001;120(1-2):152-60.
2001: J Visser; W Graffelman; Bep Blauw; Inge Haspels; E Lentjes; Ron de Kloet; Lex Nagelkerken
LPS-induced IL-10 production in whole blood cultures from chronic fatigue syndrome patients is increased but supersensitive to inhibition by dexamethasone.
Journal of neuroimmunology 2001;119(2):343-9.
2001: C L Karp; Anette H H van Boxel-Dezaire; Adriana A Byrnes; Lex Nagelkerken
Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?
Current opinion in neurology 2001;14(3):361-8.
2001: J Visser; E Lentjes; Inge Haspels; W Graffelman; Bep Blauw; Ron de Kloet; Lex Nagelkerken
Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2001;49(2):195-204.
2000: Anette H H van Boxel-Dezaire; S C van Trigt-Hoff; Joep Killestein; Hans M Schrijver; Johannes C van Houwelingen; Chris H Polman; Lex Nagelkerken
Contrasting responses to interferon beta-1b treatment in relapsing-remitting multiple sclerosis: does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment?
Annals of neurology 2000;48(3):313-22.
2000: J T Visser; Ron de Kloet; Lex Nagelkerken
Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.
Annals of the New York Academy of Sciences 2000;917():868-75.
1999: Mariken E Luca; Lizette Visser; C J Lucas; Lex Nagelkerken
IFN-beta modulates specific T cell responses in vitro but does not affect Experimental Autoimmune Encephalomyelitis in the SJL mouse.
Journal of neuroimmunology 1999;100(1-2):190-6.
1999: Anette H H van Boxel-Dezaire; S C Hoff; Bob W van Oosten; Cornelis L Verweij; A M Dräger; H J Adèr; Johannes C van Houwelingen; Frederik Barkhof; Chris H Polman; Lex Nagelkerken
Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis.
Annals of neurology 1999;45(6):695-703.
1998: J Visser; Anette H H van Boxel-Dezaire; D Methorst; T Brunt; Ron de Kloet; Lex Nagelkerken
Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro.
Blood 1998;91(11):4255-64.
1998: J Visser; Bep Blauw; B Hinloopen; E Brommer; Ron de Kloet; Cornelis Kluft; Lex Nagelkerken
CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone.
The Journal of infectious diseases 1998;177(2):451-4.
1998: Lex Nagelkerken
Role of Th1 and Th2 cells in autoimmune demyelinating disease.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1998;31(1):55-60.
1997: Lex Nagelkerken; Bep Blauw; M Tielemans
IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice.
International immunology 1997;9(9):1243-51.
1996: E W Nijhuis; F Oostervink; B Hinloopen; Jan Rozing; Lex Nagelkerken
Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia.
Brain, behavior, and immunity 1996;10(2):115-25.
1996: Edmond J Remarque; E W Nijhuis; B Hinloopen; Lex Nagelkerken; E A van der Velde; Gerard Ligthart
Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy aging.
Vaccine 1996;14(2):127-30.
1995: R Dobber; M Tielemans; Lex Nagelkerken
Enrichment for Th1 cells in the Mel-14+ CD4+ T cell fraction in aged mice.
Cellular immunology 1995;162(2):321-5.
1995: E W Nijhuis; B Hinloopen; R A van Lier; Lex Nagelkerken
Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone.
International immunology 1995;7(4):591-5.
1995: R Dobber; M Tielemans; Lex Nagelkerken
The in vivo effects of neutralizing antibodies against IFN-gamma, IL-4, or IL-10 on the humoral immune response in young and aged mice.
Cellular immunology 1995;160(2):185-92.
1994: E Nijhuis; B Hinloopen; C.M. Duijn; Albert Hofman; Jan Rozing; Lex Nagelkerken
Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease.
Clinical immunology and immunopathology 1994;73(1):45-52.
1994: R Dobber; M Tielemans; H de Weerd; Lex Nagelkerken
Mel14+ CD4+ T cells from aged mice display functional and phenotypic characteristics of memory cells.
International immunology 1994;6(8):1227-34.
1994: E W Nijhuis; B Hinloopen; J Odding; Lex Nagelkerken
Abrogation of the suppressive effects of dexamethasone by PKC activation or CD28 triggering.
Cellular immunology 1994;156(2):438-47.
1994: E W Nijhuis; Edmond J Remarque; B Hinloopen; T Van der Pouw-Kraan; R A Van Lier; Gerard Ligthart; Lex Nagelkerken
Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo.
Clinical and experimental immunology 1994;96(3):528-34.
1994: P Van den Bergh; Jan Rozing; Lex Nagelkerken
Identification of distinct sites of beta-endorphin that stimulate lymphokine production by murine CD4+ T cells.
Lymphokine and cytokine research 1994;13(2):63-9.
1994: P van den Bergh; R Dobber; S Ramlal; Jan Rozing; Lex Nagelkerken
Role of opioid peptides in the regulation of cytokine production by murine CD4+ T cells.
Cellular immunology 1994;154(1):109-22.
1993: F J Tielen; A C van Vliet; B de Geus; Lex Nagelkerken; Jan Rozing
Age-related changes in CD4+ T-cell subsets associated with prolonged skin graft survival in aging rats.
Transplantation proceedings 1993;25(5):2872-4.
1993: Kenneth Gollob; Lex Nagelkerken; Robert L Coffman
Endogenous retroviral superantigen presentation by B cells induces the development of type 1 CD4+ T helper lymphocytes.
European journal of immunology 1993;23(10):2565-71.
1993: Lex Nagelkerken; Kenneth Gollob; M Tielemans; Robert L Coffman
Role of transforming growth factor-beta in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B.
European journal of immunology 1993;23(9):2306-10.
1993: R Dobber; P van den Bergh; M Tielemans; J Schuitemaker; Lex Nagelkerken
The sensitivity of IL-4 production for cAMP inducers is lost in CD4+ T cells from aged mice.
International immunology 1993;5(9):1167-76.
1993: P van den Bergh; Jan Rozing; Lex Nagelkerken
Beta-endorphin stimulates Ia expression on mouse B cells by inducing interleukin-4 secretion by CD4+ T cells.
Cellular immunology 1993;149(1):180-92.
1993: P van den Bergh; Jan Rozing; Lex Nagelkerken
Identification of two moieties of beta-endorphin with opposing effects on rat T-cell proliferation.
Immunology 1993;79(1):18-23.
1993: Edmond J Remarque; W C van Beek; Gerard Ligthart; R J Borst; Lex Nagelkerken; Abraham M Palache; M J Sprenger; N Masurel
Improvement of the immunoglobulin subclass response to influenza vaccine in elderly nursing-home residents by the use of high-dose vaccines.
Vaccine 1993;11(6):649-54.
1992: R Dobber; A Hertogh-Huijbregts; Jan Rozing; K Bottomly; Lex Nagelkerken
The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery.
Developmental immunology 1992;2(2):141-50.
1992: Lex Nagelkerken; A Hertogh-Huijbregts
The acquisition of a memory phenotype by murine CD4+ T cells is accompanied by a loss in their capacity to increase intracellular calcium.
Developmental immunology 1992;3(1):25-34.
1992: E W Nijhuis; Lex Nagelkerken
Age-related changes in immune reactivity: the influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment.
Experimental and clinical immunogenetics 1992;9(4):195-202.
1991: H J Schuurman; Lex Nagelkerken; R A De Weger; Jan Rozing
Age-associated involution: significance of a physiologic process.
Thymus 1991;18(1):1-6.
1991: P van den Bergh; Jan Rozing; Lex Nagelkerken
Two opposing modes of action of beta-endorphin on lymphocyte function.
Immunology 1991;72(4):537-43.
1991: Lex Nagelkerken; A Hertogh-Huijbregts; R Dobber; A Dräger
Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells.
European journal of immunology 1991;21(2):273-81.
1990: A Hertogh-Huijbregts; C Vissinga; Jan Rozing; Lex Nagelkerken
Impairment of CD3-dependent and CD3-independent activation pathways in CD4+ and in CD8+ T cells from old CBA/RIJ mice.
Mechanisms of ageing and development 1990;53(2):141-55.
1990: C Vissinga; Lex Nagelkerken; J Zijlstra; A Hertogh-Huijbregts; W Boersma; Jan Rozing
A decreased functional capacity of CD4+ T cells underlies the impaired DTH reactivity in old mice.
Mechanisms of ageing and development 1990;53(2):127-39.
1990: C Vissinga; A Hertogh-Huijbregts; Jan Rozing; Lex Nagelkerken
Analysis of the age-related decline in alloreactivity of CD4+ and CD8+ T cells in CBA/RIJ mice.
Mechanisms of ageing and development 1990;51(2):179-94.
1990: B De Geus; M Van den Enden; C Coolen; Lex Nagelkerken; P Van der Heijden; Jan Rozing
Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated gamma delta T cell receptor.
European journal of immunology 1990;20(2):291-8.