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Janice Nagy

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Basel Sitohy; Shou-Ching Shih Jaminet; Janice A Nagy; Harold F Dvorak
Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.
Yineng Fu; Janice A Nagy; Lawrence F Brown; Shou-Ching Shih; Pamela Y Johnson; Christina K Chan; Harold F Dvorak; Thomas N Wight
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis.
Mien V Hoang; Janice A Nagy; Donald R Senger
Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.

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2011: Basel Sitohy; Shou-Ching Shih Jaminet; Janice A Nagy; Harold F Dvorak
Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.
Cancer research 2011;71(22):7021-8.
2011: Yineng Fu; Janice A Nagy; Lawrence F Brown; Shou-Ching Shih; Pamela Y Johnson; Christina K Chan; Harold F Dvorak; Thomas N Wight
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2011;59(5):463-73.
2011: Mien V Hoang; Janice A Nagy; Donald R Senger
Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.
Blood 2011;117(5):1751-60.
2011: Mien V Hoang; Janice A Nagy; Donald R Senger
Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis.
Microvascular research 2011;81(1):34-43.
2010: Mien V Hoang; Janice A Nagy; Joan E B Fox; Donald R Senger
Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis.
PloS one 2010;5(10):e13612.
2009: Qi Xue; Janice A Nagy; Eleanor J Manseau; Thuy L Phung; Harold F Dvorak; Laura E Benjamin
Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(8):1172-8.
2008: Janice A Nagy; Laura Benjamin; Huiyan Zeng; Ann M Dvorak; Harold F Dvorak
Vascular permeability, vascular hyperpermeability and angiogenesis.
Angiogenesis 2008;11(2):109-19.
2007: Maria Wirzenius; Tuomas Tammela; Marko Uutela; Yulong He; Teresa Odorisio; Giovanna Zambruno; Janice A Nagy; Harold F Dvorak; Seppo Ylä-Herttuala; Masabumi Shibuya; Kari Alitalo
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
The Journal of experimental medicine 2007;204(6):1431-40.
2007: Janice A Nagy; Ann M Dvorak; Harold F Dvorak
VEGF-A and the induction of pathological angiogenesis.
Annual review of pathology 2007;2():251-75.
2006: Liuliang Qin; Dezheng Zhao; Xin Liu; Janice A Nagy; Mien Van Hoang; Lawrence F Brown; Harold F Dvorak; Huiyan Zeng
Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.
Molecular cancer research : MCR 2006;4(11):811-20.
2006: Thuy L Phung; Keren Ziv; Donnette Dabydeen; Godfred Eyiah-Mensah; Marcela Riveros; Carole Perruzzi; Jingfang Sun; Rita A Monahan-Earley; Ichiro Shiojima; Janice A Nagy; Michelle I Lin; Kenneth Walsh; Ann M Dvorak; David M Briscoe; Michal Neeman; William C Sessa; Harold F Dvorak; Laura E Benjamin
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Cancer cell 2006;10(2):159-70.
2006: Janice A Nagy; Dian Feng; Eliza Vasile; Wendy H Wong; Shu-Ching Shih; Ann M Dvorak; Harold F Dvorak
Permeability properties of tumor surrogate blood vessels induced by VEGF-A.
Laboratory investigation; a journal of technical methods and pathology 2006;86(8):767-80.
2006: Huiyan Zeng; Liuliang Qin; Dezheng Zhao; Xiaolian Tan; Eleanor J Manseau; Mien Van Hoang; Donald R Senger; Lawrence F Brown; Janice A Nagy; Harold F Dvorak
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.
The Journal of experimental medicine 2006;203(3):719-29.
2006: Janice A Nagy; Donald R Senger
VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype.
Experimental cell research 2006;312(5):538-48.
2005: Ronit Satchi-Fainaro; Roni Mamluk; Ling Wang; Sarah M Short; Janice A Nagy; Dian Feng; Ann M Dvorak; Harold F Dvorak; Mark Puder; Debabrata Mukhopadhyay; Judah Folkman
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
Cancer cell 2005;7(3):251-61.
2004: Dian Feng; Janice A Nagy; Kathryn Pyne; Harold F Dvorak; Ann M Dvorak
Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(1):87-101.
2003: Liesbeth Hekking; V Susan Harvey; Carin E G Havenith; Jacob Van Den Born; Robert H J Beelen; Robert Jackman; Janice A Nagy
Mesothelial cell transplantation in models of acute inflammation and chronic peritoneal dialysis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2003;23(4):323-30.
2003: Janice A Nagy; Ann M Dvorak; Harold F Dvorak
VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.
Trends in cardiovascular medicine 2003;13(5):169-75.
2002: Janice A Nagy; Eliza Vasile; Dian Feng; Christian Sundberg; Lawrence F Brown; Michael Detmar; Joel Lawitts; Laura Benjamin; Xiaolian Tan; Eleanor J Manseau; Ann M Dvorak; Harold F Dvorak
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
The Journal of experimental medicine 2002;196(11):1497-506.
2002: Aernout Luttun; Marc Tjwa; Lieve Moons; Yan Wu; Anne Angelillo-Scherrer; Fang Liao; Janice A Nagy; Andrea Hooper; Josef Priller; Bert De Klerck; Veerle Compernolle; Evis Daci; Peter Bohlen; Mieke Dewerchin; Jean-Marc Herbert; Roy Fava; Patrick Matthys; Geert Carmeliet; Désiré Collen; Harold F Dvorak; Daniel J Hicklin; Peter Carmeliet
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.
Nature medicine 2002;8(8):831-40.
2002: Dian Feng; Janice A Nagy; Harold F Dvorak; Ann M Dvorak
Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals.
Microscopy research and technique 2002;57(5):289-326.
2002: Janice A Nagy; Eliza Vasile; Dian Feng; Christian Sundberg; Lawrence F Brown; Eleanor J Manseau; Ann M Dvorak; Harold F Dvorak
VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations.
Cold Spring Harbor symposia on quantitative biology 2002;67():227-37.
2001: S Basu; Janice A Nagy; S Pal; Eliza Vasile; IA Eckelhoefer; V S Bliss; Eleanor J Manseau; Partha Sarathi Dasgupta; Harold F Dvorak; Debabrata Mukhopadhyay
The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor.
Nature medicine 2001;7(5):569-74.
2001: Christian Sundberg; Janice A Nagy; Lawrence F Brown; Dian Feng; IA Eckelhoefer; Eleanor J Manseau; Ann M Dvorak; Harold F Dvorak
Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery.
The American journal of pathology 2001;158(3):1145-60.
2000: S Pal; M Luisa Iruela-Arispe; V Susan Harvey; Huiyan Zeng; Janice A Nagy; Harold F Dvorak; Debabrata Mukhopadhyay
Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade.
Microvascular research 2000;60(2):112-20.
2000: Dian Feng; Janice A Nagy; Rolf Brekken; A Pettersson; Eleanor J Manseau; Kathryn Pyne; R Mulligan; P E Thorpe; Harold F Dvorak; Ann M Dvorak
Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(4):545-56.
2000: A Pettersson; Janice A Nagy; Lawrence F Brown; Christian Sundberg; E Morgan; S Jungles; R Carter; J E Krieger; Eleanor J Manseau; V Susan Harvey; IA Eckelhoefer; Dian Feng; Ann M Dvorak; R C Mulligan; Harold F Dvorak
Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor.
Laboratory investigation; a journal of technical methods and pathology 2000;80(1):99-115.
2000: D Feng; Janice A Nagy; A M Dvorak; Harold F Dvorak
Different pathways of macromolecule extravasation from hyperpermeable tumor vessels.
Microvascular research 2000;59(1):24-37.
1999: Dian Feng; Janice A Nagy; Kathryn Pyne; Ilan Hammel; Harold F Dvorak; Ann M Dvorak
Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators.
Microcirculation (New York, N.Y. : 1994) 1999;6(1):23-44.
1999: Harold F Dvorak; Janice A Nagy; Dian Feng; Lawrence F Brown; Ann M Dvorak
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.
Current topics in microbiology and immunology 1999;237():97-132.
1998: Dian Feng; Janice A Nagy; Kathryn Pyne; Harold F Dvorak; Ann M Dvorak
Platelets exit venules by a transcellular pathway at sites of F-met peptide-induced acute inflammation in guinea pigs.
International archives of allergy and immunology 1998;116(3):188-95.
1998: C M Hoff; J L Cusick; E M Masse; Robert Jackman; Janice A Nagy; Ty R Shockley
Modulation of transgene expression in mesothelial cells by activation of an inducible promoter.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(6):1420-9.
1998: Robert Jackman; T D Stapleton; E M Masse; V Susan Harvey; M S Meyers; Ty R Shockley; Janice A Nagy
Enhancement of the functional repertoire of the rat parietal peritoneal mesothelium in vivo: directed expression of the anticoagulant and antiinflammatory molecule thrombomodulin.
Human gene therapy 1998;9(7):1069-81.
1998: Dian Feng; Janice A Nagy; Kathryn Pyne; Harold F Dvorak; Ann M Dvorak
Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP.
The Journal of experimental medicine 1998;187(6):903-15.
1998: Debabrata Mukhopadhyay; Janice A Nagy; Eleanor J Manseau; Harold F Dvorak
Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium.
Cancer research 1998;58(6):1278-84.
1997: Dian Feng; Janice A Nagy; J Hipp; Kathryn Pyne; Harold F Dvorak; Ann M Dvorak
Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: many are transcellular pores.
The Journal of physiology 1997;504 ( Pt 3)():747-61.
1997: Lawrence F Brown; Michael Detmar; Kevin P Claffey; Janice A Nagy; D Feng; Ann M Dvorak; Harold F Dvorak
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
EXS 1997;79():233-69.
1996: Janice A Nagy; I A Eckelhoefer; E M Masse; Ann M Dvorak; Harold F Dvorak
Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor.
European journal of cancer (Oxford, England : 1990) 1996;32A(14):2467-73.
1996: Janice A Nagy
Peritoneal membrane morphology and function.
Kidney international. Supplement 1996;56():S2-11.
1996: T K Yeo; Janice A Nagy; K T Yeo; Harold F Dvorak; Bryan P Toole
Increased hyaluronan at sites of attachment to mesentery by CD44-positive mouse ovarian and breast tumor cells.
The American journal of pathology 1996;148(6):1733-40.
1996: Dian Feng; Janice A Nagy; J Hipp; Harold F Dvorak; Ann M Dvorak
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.
The Journal of experimental medicine 1996;183(5):1981-6.
1996: Ann M Dvorak; S Kohn; Ellen S Morgan; P Fox; Janice A Nagy; Harold F Dvorak
The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation.
Journal of leukocyte biology 1996;59(1):100-15.
1995: Janice A Nagy; Ty R Shockley; E M Masse; V S Harvey; C M Hoff; Robert Jackman
Systemic delivery of a recombinant protein by genetically modified mesothelial cells reseeded on the parietal peritoneal surface.
Gene therapy 1995;2(6):402-10.
1995: Janice A Nagy; Ty R Shockley; E M Masse; V S Harvey; Robert Jackman
Mesothelial cell-mediated gene therapy: feasibility of an ex vivo strategy.
Gene therapy 1995;2(6):393-401.
1995: Michael Detmar; K T Yeo; Janice A Nagy; Livingston Van De Water; Lawrence F Brown; Brygida Berse; B M Elicker; S Ledbetter; Harold F Dvorak
Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells.
The Journal of investigative dermatology 1995;105(1):44-50.
1995: Harold F Dvorak; Michael Detmar; Kevin P Claffey; Janice A Nagy; Livingston Van De Water; D R Senger
Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation.
International archives of allergy and immunology 1995;107(1-3):233-5.
1995: Janice A Nagy; D R Senger; Harold F Dvorak; Ann M Dvorak
Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(4):381-9.
1995: Janice A Nagy; M S Meyers; E M Masse; K T Herzberg; Harold F Dvorak
Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity.
Cancer research 1995;55(2):369-75.
1995: Janice A Nagy; E M Masse; K T Herzberg; M S Meyers; K T Yeo; T K Yeo; T M Sioussat; Harold F Dvorak
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation.
Cancer research 1995;55(2):360-8.
1995: Janice A Nagy; Ellen S Morgan; K T Herzberg; Eleanor J Manseau; A M Dvorak; Harold F Dvorak
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.
Cancer research 1995;55(2):376-85.
1994: K Lin; Janice A Nagy; H Xu; Ty R Shockley; Martin L Yarmush; Harold F Dvorak
Compartmental distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.
Cancer research 1994;54(8):2269-77.
1993: D R Senger; Livingston Van De Water; Lawrence F Brown; Janice A Nagy; K T Yeo; T K Yeo; Brygida Berse; Robert Jackman; Ann M Dvorak; Harold F Dvorak
Vascular permeability factor (VPF, VEGF) in tumor biology.
Cancer metastasis reviews 1993;12(3-4):303-24.
1993: K T Yeo; H H Wang; Janice A Nagy; T M Sioussat; S R Ledbetter; A J Hoogewerf; Y Zhou; E M Masse; D R Senger; Harold F Dvorak
Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.
Cancer research 1993;53(12):2912-8.
1993: Janice A Nagy; K T Herzberg; J M Dvorak; Harold F Dvorak
Pathogenesis of malignant ascites formation: initiating events that lead to fluid accumulation.
Cancer research 1993;53(11):2631-43.
1992: Harold F Dvorak; Janice A Nagy; Brygida Berse; Lawrence F Brown; K T Yeo; T K Yeo; Ann M Dvorak; Livingston Van De Water; T M Sioussat; D R Senger
Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma formation.
Annals of the New York Academy of Sciences 1992;667():101-11.
1992: S Kohn; Janice A Nagy; Harold F Dvorak; Ann M Dvorak
Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.
Laboratory investigation; a journal of technical methods and pathology 1992;67(5):596-607.
1992: Ty R Shockley; K Lin; Janice A Nagy; Ronald G Tompkins; Martin L Yarmush; Harold F Dvorak
Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.
Cancer research 1992;52(2):367-76.
1992: Ty R Shockley; K Lin; Cynthia Sung; Janice A Nagy; Ronald G Tompkins; Robert L Dedrick; Harold F Dvorak; Martin L Yarmush
A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels.
Cancer research 1992;52(2):357-66.
1992: Janice A Nagy
Lymphatic and nonlymphatic pathways of peritoneal absorption in mice: physiology versus pathology.
Blood purification 1992;10(3-4):148-62.
1991: Harold F Dvorak; T M Sioussat; Lawrence F Brown; Brygida Berse; Janice A Nagy; A Sotrel; Eleanor J Manseau; Livingston Van De Water; D R Senger
Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.
The Journal of experimental medicine 1991;174(5):1275-8.
1991: Harold F Dvorak; Janice A Nagy; A M Dvorak
Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(3):77-85.
1991: Ty R Shockley; K Lin; Janice A Nagy; Ronald G Tompkins; Harold F Dvorak; Martin L Yarmush
Penetration of tumor tissue by antibodies and other immunoproteins.
Annals of the New York Academy of Sciences 1991;618():367-82.
1989: Janice A Nagy; K T Herzberg; E M Masse; G P Zientara; Harold F Dvorak
Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice.
Cancer research 1989;49(19):5448-58.
1989: Janice A Nagy; Lawrence F Brown; D R Senger; N Lanir; Livingston Van De Water; Ann M Dvorak; Harold F Dvorak
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition.
Biochimica et biophysica acta 1989;948(3):305-26.
1988: Harold F Dvorak; Janice A Nagy; J T Dvorak; Ann M Dvorak
Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.
The American journal of pathology 1988;133(1):95-109.
1988: Janice A Nagy; R L Kradin; J McDonagh
Biosynthesis of factor XIII A and B subunits.
Advances in experimental medicine and biology 1988;231():29-49.
1986: Janice A Nagy; P Henriksson; J McDonagh
Biosynthesis of factor XIII B subunit by human hepatoma cell lines.
Blood 1986;68(6):1272-9.