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Stefan Nahorski

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Carl P Nelson; Stefan R Nahorski; R A John Challiss
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.
Elizabeth M Rosethorne; Stefan R Nahorski; R A John Challiss
Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.
Jonathon M Willets; Carl P Nelson; Stefan R Nahorski; R A John Challiss
The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons.

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2008: Carl P Nelson; Stefan R Nahorski; R A John Challiss
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.
Journal of neurochemistry 2008;107(3):602-15.
2008: Elizabeth M Rosethorne; Stefan R Nahorski; R A John Challiss
Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.
Biochemical pharmacology 2008;75(4):942-55.
2007: Jonathon M Willets; Carl P Nelson; Stefan R Nahorski; R A John Challiss
The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons.
Journal of neurochemistry 2007;103(6):2268-80.
2006: Daniela Billups; Brian Billups; R A John Challiss; Stefan R Nahorski
Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):9983-95.
2006: Mark R Dowling; Jonathon M Willets; David C Budd; Steven J Charlton; Stefan R Nahorski; R A John Challiss
A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1134-42.
2006: Stefan R Nahorski
Pharmacology of intracellular signalling pathways.
British journal of pharmacology 2006;147 Suppl 1():S38-45.
2006: Peter J Atkinson; Kenneth W Young; Steven J Ennion; James N C Kew; Stefan R Nahorski; R A John Challiss
Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling.
Molecular pharmacology 2006;69(1):174-84.
2006: Carl P Nelson; Stefan R Nahorski; R A John Challiss
Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
The Journal of pharmacology and experimental therapeutics 2006;316(1):279-88.
2005: Kenneth W Young; Daniela Billups; Carl P Nelson; Neil Johnston; Jonathon M Willets; Michael J Schell; R A John Challiss; Stefan R Nahorski
Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion.
Molecular and cellular neurosciences 2005;30(1):48-57.
2005: Paula J Bartlett; Kenneth W Young; Stefan R Nahorski; R A John Challiss
Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors.
The Journal of biological chemistry 2005;280(23):21837-46.
2005: Jonathon M Willets; Stefan R Nahorski; R A John Challiss
Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons.
The Journal of biological chemistry 2005;280(19):18950-8.
2005: Helen K Warwick; Stefan R Nahorski; R A John Challiss
Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+ - and protein kinase C-dependent pathway.
Journal of neurochemistry 2005;93(1):232-45.
2004: Mark S Nash; Jonathon M Willets; Brian Billups; RA John Challiss; Stefan R Nahorski
Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to facilitate Ca2+ release in hippocampal neurons.
The Journal of biological chemistry 2004;279(47):49036-44.
2004: Carl P Nelson; Paul Gupta; Carolyn M Napier; Stefan R Nahorski; R A John Challiss
Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1255-65.
2004: Kenneth W Young; M Asier Garro; R A John Challiss; Stefan R Nahorski
NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C activation in single cerebellar granule neurons.
Journal of neurochemistry 2004;89(6):1537-46.
2004: Jonathon M Willets; Mark S Nash; R A John Challiss; Stefan R Nahorski
Imaging of muscarinic acetylcholine receptor signaling in hippocampal neurons: evidence for phosphorylation-dependent and -independent regulation by G-protein-coupled receptor kinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(17):4157-62.
2004: Mark R Dowling; Stefan R Nahorski; R A John Challiss
Measurement of agonist-stimulated [35S]GTPgammaS binding to assess total G-protein and Galpha-subtype-specific activation by G-protein-coupled receptors.
Methods in molecular biology (Clifton, N.J.) 2004;259():197-206.
2003: Jonathon M Willets; R A John Challiss; Stefan R Nahorski
Non-visual GRKs: are we seeing the whole picture?
Trends in pharmacological sciences 2003;24(12):626-33.
2003: Jonathon M Willets; Rajendra Mistry; Stefan R Nahorski; R A John Challiss
Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling.
Molecular pharmacology 2003;64(5):1059-68.
2003: Stefan R Nahorski; Kenneth W Young; RA John Challiss; Mark S Nash
Visualizing phosphoinositide signalling in single neurons gets a green light.
Trends in neurosciences 2003;26(8):444-52.
2003: Kenneth W Young; Mark S Nash; R A John Challiss; Stefan R Nahorski
Role of Ca2+ feedback on single cell inositol 1,4,5-trisphosphate oscillations mediated by G-protein-coupled receptors.
The Journal of biological chemistry 2003;278(23):20753-60.
2003: Kenneth W Young; Jonathon M Willets; M Janine Parkinson; Paula Bartlett; Sarah Spiegel; Stefan R Nahorski; R A John Challiss
Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.
Cell calcium 2003;33(2):119-28.
2002: Kenneth W Young; Stefan R Nahorski
Sphingosine 1-phosphate: a Ca2+ release mediator in the balance.
Cell calcium 2002;32(5-6):335-41.
2002: Mark S Nash; Michael J Schell; Peter J Atkinson; Neil R Johnston; Stefan R Nahorski; R A John Challiss
Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration.
The Journal of biological chemistry 2002;277(39):35947-60.
2002: Jonathon M Willets; R A John Challiss; Stefan R Nahorski
Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells.
The Journal of biological chemistry 2002;277(18):15523-9.
2001: Mark S Nash; Kenneth W Young; R A John Challiss; Stefan R Nahorski
Intracellular signalling. Receptor-specific messenger oscillations.
Nature 2001;413(6854):381-2.
2001: R A Bundey; Stefan R Nahorski
Homologous and heterologous uncoupling of muscarinic M(3) and alpha(1B) adrenoceptors to Galpha(q/11) in SH-SY5Y human neuroblastoma cells.
British journal of pharmacology 2001;134(2):257-64.
2001: Jonathon M Willets; R A John Challiss; Eamonn Kelly; Stefan R Nahorski
G protein-coupled receptor kinases 3 and 6 use different pathways to desensitize the endogenous M3 muscarinic acetylcholine receptor in human SH-SY5Y cells.
Molecular pharmacology 2001;60(2):321-30.
2001: L M Wheldon; Stefan R Nahorski; Gary B Willars
Inositol 1,4,5-trisphosphate-independent calcium signalling by platelet-derived growth factor in the human SH-SY5Y neuroblastoma cell.
Cell calcium 2001;30(2):95-106.
2001: Mark S Nash; Julie V Selkirk; C E Gaymer; R A John Challiss; Stefan R Nahorski
Enhanced inducible mGlu1alpha receptor expression in Chinese hamster ovary cells.
Journal of neurochemistry 2001;77(6):1664-7.
2001: Mark S Nash; R Saunders; Kenneth W Young; R A John Challiss; Stefan R Nahorski
Reassessment of the Ca2+ sensing property of a type I metabotropic glutamate receptor by simultaneous measurement of inositol 1,4,5-trisphosphate and Ca2+ in single cells.
The Journal of biological chemistry 2001;276(22):19286-93.
2001: Mark S Nash; Kenneth W Young; Gary B Willars; R A John Challiss; Stefan R Nahorski
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.
The Biochemical journal 2001;356(Pt 1):137-42.
2001: Julie V Selkirk; Gary W Price; Stefan R Nahorski; R A John Challiss
Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populations.
Neuropharmacology 2001;40(5):645-56.
2001: Gary B Willars; J E Royall; Stefan R Nahorski; F El-Gehani; HM Everest; Craig A McArdle
Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropes.
The Journal of biological chemistry 2001;276(5):3123-9.
2001: E C Akam; R A John Challiss; Stefan R Nahorski
G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype.
British journal of pharmacology 2001;132(4):950-8.
2001: Kenneth W Young; Stefan R Nahorski
Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release.
Seminars in cell & developmental biology 2001;12(1):19-25.
2001: Roser Masgrau; Joan-Marc Servitja; Kenneth W Young; Raul Pardo; Elisabet Sarri; Stefan R Nahorski; Fernando Picatoste
Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium-dependence of the phospholipase C response.
The European journal of neuroscience 2001;13(2):248-56.
2000: Kenneth W Young; Martin D Bootman; D R Channing; Peter Lipp; Peter R Maycox; Jackie Meakin; R A John Challiss; Stefan R Nahorski
Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.
The Journal of biological chemistry 2000;275(49):38532-9.
2000: Kenneth W Young; D R Channing; Stefan R Nahorski
Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells.
European journal of pharmacology 2000;402(1-2):55-9.
2000: E Hermans; R Saunders; Julie V Selkirk; Rajendra Mistry; Stefan R Nahorski; R A John Challiss
Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells.
Molecular pharmacology 2000;58(2):352-60.
2000: Roser Masgrau; Joan-Marc Servitja; Elisabet Sarri; Kenneth W Young; Stefan R Nahorski; Fernando Picatoste
Intracellular Ca2+ stores regulate muscarinic receptor stimulation of phospholipase C in cerebellar granule cells.
Journal of neurochemistry 2000;74(2):818-26.
1999: Gary B Willars; W Müller-Esterl; Stefan R Nahorski
Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.
The American journal of physiology 1999;277(5 Pt 1):C859-69.
1999: Gary B Willars; Anders Heding; Milka Vrecl; Robin Sellar; Marion Blomenröhr; Stefan R Nahorski; Karin A Eidne
Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization.
The Journal of biological chemistry 1999;274(42):30146-53.
1999: N Mody; E Hermans; Stefan R Nahorski; R A John Challiss
Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function.
Neuropharmacology 1999;38(10):1485-92.
1999: Kenneth W Young; R A John Challiss; Stefan R Nahorski; John J Mackrill
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.
The Biochemical journal 1999;343 Pt 1():45-52.
1999: R J Davis; J Challiss; Stefan R Nahorski
Enhanced purinoceptor-mediated Ca2+ signalling in L-fibroblasts overexpressing type 1 inositol 1,4,5-trisphosphate receptors.
The Biochemical journal 1999;341 ( Pt 3)():813-20.
1999: M S Shockley; LM Tolbert; A B Tobin; Stefan R Nahorski; Wolfgang Sadée; J Lameh
Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.
European journal of pharmacology 1999;377(1):137-46.
1999: A K Martin; Stefan R Nahorski; Gary B Willars
Complex relationship between Ins(1,4,5)P3 accumulation and Ca2+ -signalling in a human neuroblastoma reveled by cellular differentiation.
British journal of pharmacology 1999;126(7):1559-66.
1999: M G Waugh; R A John Challiss; G Berstein; Stefan R Nahorski; Andrew B Tobin
Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors.
The Biochemical journal 1999;338 ( Pt 1)():175-83.
1999: E Hermans; R A John Challiss; Stefan R Nahorski
Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists.
British journal of pharmacology 1999;126(4):873-82.
1999: E Hermans; Stefan R Nahorski; R A John Challiss
Heterologous mammalian expression systems for investigating the properties of metabotropic glutamate receptors.
Biochemical Society transactions 1999;27(2):164-70.
1999: W Forrest-Owen; Gary B Willars; Stefan R Nahorski; D Assefa; James S Davidson; James N Hislop; Craig A McArdle
The lack of gonadotrophin-releasing hormone (GnRH) receptor desensitisation in alphaT3-1 cells is not due to GnRH receptor reserve or phosphatidylinositol 4,5-bis-phosphate pool size.
Molecular and cellular endocrinology 1999;147(1-2):161-73.
1998: E Hermans; Stefan R Nahorski; R A John Challiss
Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor.
Neuropharmacology 1998;37(12):1645-7.
1998: Robert A Wilcox; W U Primrose; Stefan R Nahorski; R A Challiss
New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.
Trends in pharmacological sciences 1998;19(11):467-75.
1998: D K Boxall; anthony ford; Agnes Choppin; Stefan R Nahorski; R A John Challiss; Richard M Eglen
Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus.
British journal of pharmacology 1998;124(8):1615-22.
1998: Gary B Willars; Craig A McArdle; Stefan R Nahorski
Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitization.
The Biochemical journal 1998;333 ( Pt 2)():301-8.
1998: Kenneth W Young; RD Pinnock; Stefan R Nahorski
Determination of the inositol (1,4,5) trisphosphate requirement for histamine- and substance P-induced Ca2+ mobilisation in human U373 MG astrocytoma cells.
Cell calcium 1998;24(1):59-70.
1998: Nigel J Brunskill; J Stuart; A B Tobin; John Walls; Stefan R Nahorski
Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase.
The Journal of clinical investigation 1998;101(10):2140-50.
1998: E Hermans; Kenneth W Young; R A John Challiss; Stefan R Nahorski
Effects of human type 1alpha metabotropic glutamate receptor expression level on phosphoinositide and Ca2+ signalling in an inducible cell expression system.
Journal of neurochemistry 1998;70(4):1772-5.
1998: Gary B Willars; Stefan R Nahorski; R A John Challiss
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
The Journal of biological chemistry 1998;273(9):5037-46.
1998: R Saunders; Stefan R Nahorski; R A John Challiss
A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
Neuropharmacology 1998;37(2):273-6.
1997: John J Mackrill; R A John Challiss; D A O'connell; F Anthony Lai; Stefan R Nahorski
Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines.
The Biochemical journal 1997;327 ( Pt 1)():251-8.
1997: Alan Carruthers; R A John Challiss; Rajendra Mistry; R Saunders; C Thomsen; Stefan R Nahorski
Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment.
Molecular pharmacology 1997;52(3):406-14.
1997: Andrew B Tobin; N F Totty; A E Sterlin; Stefan R Nahorski
Stimulus-dependent phosphorylation of G-protein-coupled receptors by casein kinase 1alpha.
The Journal of biological chemistry 1997;272(33):20844-9.
1997: E C Akam; Alan Carruthers; Stefan R Nahorski; R A John Challiss
Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding.
British journal of pharmacology 1997;121(6):1203-9.
1997: N T Burford; Stefan R Nahorski; S K Chung; Y T Chang; Robert A Wilcox
Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor.
Cell calcium 1997;21(4):301-10.
1997: Robert A Wilcox; A Fauq; Alan P Kozikowski; Stefan R Nahorski
Defining the minimal structural requirements for partial agonism at the type I myo-inositol 1,4,5-trisphosphate receptor.
FEBS letters 1997;402(2-3):241-5.
1997: Nigel J Brunskill; Stefan R Nahorski; John Walls
Characteristics of albumin binding to opossum kidney cells and identification of potential receptors.
Pflügers Archiv : European journal of physiology 1997;433(4):497-504.
1997: Stefan R Nahorski; Andrew B Tobin; Gary B Willars
Muscarinic M3 receptor coupling and regulation.
Life sciences 1997;60(13-14):1039-45.
1996: Craig A McArdle; Gary B Willars; R C Fowkes; Stefan R Nahorski; James S Davidson; W Forrest-Owen
Desensitization of gonadotropin-releasing hormone action in alphaT3-1 cells due to uncoupling of inositol 1,4,5-trisphosphate generation and Ca2+ mobilization.
The Journal of biological chemistry 1996;271(39):23711-7.
1996: John J Mackrill; Robert A Wilcox; A Miyawaki; K Mikoshiba; Stefan R Nahorski; R A John Challiss
Stable overexpression of the type-1 inositol 1,4,5-trisphosphate receptor in L fibroblasts: subcellular distribution and functional consequences.
The Biochemical journal 1996;318 ( Pt 3)():871-8.
1996: Gary B Willars; R A John Challiss; Stefan R Nahorski
Acute regulation of the receptor-mediated phosphoinositide signal transduction pathway.
Journal of lipid mediators and cell signalling 1996;14(1-3):157-68.
1996: Robert A Wilcox; J Strupish; Stefan R Nahorski
Quantal calcium release in electropermeabilized SH-SY5Y neuroblastoma cells perfused with myo-inositol 1,4,5-trisphosphate.
Cell calcium 1996;20(3):243-55.
1996: Nigel J Brunskill; N Cockcroft; Stefan R Nahorski; John Walls
Albumin endocytosis is regulated by heterotrimeric GTP-binding protein G alpha i-3 in opossum kidney cells.
The American journal of physiology 1996;271(2 Pt 2):F356-64.
1996: P B Simpson; Stefan R Nahorski; R A John Challiss
Agonist-evoked Ca2+ mobilization from stores expressing inositol 1,4,5-trisphosphate receptors and ryanodine receptors in cerebellar granule neurones.
Journal of neurochemistry 1996;67(1):364-73.
1996: Gary B Willars; R A John Challiss; J A Stuart; Stefan R Nahorski
Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma.
The Biochemical journal 1996;316 ( Pt 3)():905-13.
1996: N T Burford; Stefan R Nahorski
Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation.
The Biochemical journal 1996;315 ( Pt 3)():883-8.
1996: Robert A Wilcox; Stefan R Nahorski
Inositol 1,4,5-trisphosphate perfusion of electropermeabilised SH-SY5Y neuroblastoma cells produces quantal calcium uptake and release.
Biochemical Society transactions 1996;24(1):58S.
1995: Andrew B Tobin; Gary B Willars; N T Burford; Stefan R Nahorski
Relationship between agonist binding, phosphorylation and immunoprecipitation of the m3-muscarinic receptor, and second messenger responses.
British journal of pharmacology 1995;116(2):1723-8.
1995: M Godwin; S Jenkinson; Stefan R Nahorski; R A John Challiss
Effect of lithium on muscarinic cholinoceptor-stimulated phosphoinositide-specific phospholipase C substrate selectivity in CHO-m1 cells.
Biochemical Society transactions 1995;23(3):421S.
1995: Robert A Wilcox; C Erneux; WU Primrose; R Gigg; Stefan R Nahorski
2-Hydroxyethyl alpha-D-glucopyranoside 2,3',4'-trisphosphate: a novel metabolically resistant adenophostin A and myo-inositol 1,4,5-trisphosphate analogue potently interacts with the myo-inositol 1,4,5-trisphosphate receptor.
Biochemical Society transactions 1995;23(3):420S.
1995: N T Burford; Andrew B Tobin; Stefan R Nahorski
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
The Journal of pharmacology and experimental therapeutics 1995;274(1):134-42.
1995: P B Simpson; R A John Challiss; Stefan R Nahorski
Neuronal Ca2+ stores: activation and function.
Trends in neurosciences 1995;18(7):299-306.
1995: Robert A Wilcox; C Erneux; WU Primrose; R Gigg; Stefan R Nahorski
2-Hydroxyethyl-alpha-D-glucopyranoside-2,3',4'-trisphosphate, a novel, metabolically resistant, adenophostin A and myo-inositol-1,4,5-trisphosphate analogue, potently interacts with the myo-inositol-1,4,5-trisphosphate receptor.
Molecular pharmacology 1995;47(6):1204-11.
1995: P B Simpson; R A John Challiss; Stefan R Nahorski
Divalent cation entry in cultured rat cerebellar granule cells measured using Mn2+ quench of fura 2 fluorescence.
The European journal of neuroscience 1995;7(5):831-40.
1995: N T Burford; Andrew B Tobin; Stefan R Nahorski
Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins.
European journal of pharmacology 1995;289(2):343-51.
1995: John R Traynor; Stefan R Nahorski
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Molecular pharmacology 1995;47(4):848-54.
1995: J R Purkiss; Stefan R Nahorski; Gary B Willars
Mobilization of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores supports bradykinin- and muscarinic-evoked release of [3H] noradrenaline from SH-SY5Y cells.
Journal of neurochemistry 1995;64(3):1175-82.
1995: D W Gray; E M Whitham; R A John Challiss; Stefan R Nahorski
Muscarinic cholinoceptor-stimulated synthesis and degradation of inositol 1,4,5-trisphosphate in the rat cerebellar granule cell.
Journal of neurochemistry 1995;64(3):1143-51.
1995: Gary B Willars; Stefan R Nahorski
Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?
Molecular pharmacology 1995;47(3):509-16.
1995: Gary B Willars; Stefan R Nahorski
Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells.
British journal of pharmacology 1995;114(6):1133-42.
1995: Robert A Wilcox; J Strupish; Stefan R Nahorski
Measurement of Ca2+ fluxes in permeabilized cells using 45Ca2+ and fluo-3.
Methods in molecular biology (Clifton, N.J.) 1995;41():215-27.
1994: P B Simpson; R A John Challiss; Stefan R Nahorski
Chronic activation of muscarinic and metabotropic glutamate receptors down-regulates type I inositol 1,4,5-trisphosphate receptor expression in cerebellar granule cells.
Journal of neurochemistry 1994;63(6):2369-72.
1994: S Jenkinson; Stefan R Nahorski; R A John Challiss
Disruption by lithium of phosphatidylinositol-4,5-bisphosphate supply and inositol-1,4,5-trisphosphate generation in Chinese hamster ovary cells expressing human recombinant m1 muscarinic receptors.
Molecular pharmacology 1994;46(6):1138-48.
1994: Stefan R Nahorski; Robert A Wilcox; John J Mackrill; R A John Challiss
Phosphoinositide-derived second messengers and the regulation of Ca2+ in vascular smooth muscle.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1994;12(10):S133-43.
1994: Edwin R Chilvers; M A Giembycz; R A John Challiss; G J Offer; Stefan R Nahorski
Effect of temperature on muscarinic cholinoceptor-mediated phosphoinositide metabolism and tension generation in bovine tracheal smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(6):585-91.
1994: J R Purkiss; Gary B Willars; Stefan R Nahorski
Mobilisation of intracellular Ca2+ triggers [3H]-noradrenaline release from SH-SY5Y cells.
Biochemical Society transactions 1994;22(4):417S.
1994: Robert A Wilcox; R A John Challiss; John R Traynor; Abdul Fauq; V I Ognayanov; Alan P Kozikowski; Stefan R Nahorski
Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1994;269(43):26815-21.
1994: D W Gray; R A John Challiss; Stefan R Nahorski
Differential effects of lithium on muscarinic cholinoceptor-stimulated CMP-phosphatidate accumulation in cerebellar granule cells, CHO-M3 cells, and SH-SY5Y neuroblastoma cells.
Journal of neurochemistry 1994;63(4):1354-60.
1994: Steve Safrany; S J Mills; C Liu; D Lampe; N J Noble; Stefan R Nahorski; B V Potter
Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase.
Biochemistry 1994;33(35):10763-9.
1994: R J Wojcikiewicz; Andrew B Tobin; Stefan R Nahorski
Muscarinic receptor-mediated inositol 1,4,5-trisphosphate formation in SH-SY5Y neuroblastoma cells is regulated acutely by cytosolic Ca2+ and by rapid desensitization.
Journal of neurochemistry 1994;63(1):177-85.
1994: Robert A Wilcox; Steve Safrany; D Lampe; S J Mills; Stefan R Nahorski; B V Potter
Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities.
European journal of biochemistry / FEBS 1994;223(1):115-24.
1994: Steve Safrany; Stefan R Nahorski
A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells.
Neuropharmacology 1994;33(7):837-46.
1994: P C Wood; R J Wojcikiewicz; J Burgess; C M Castleden; Stefan R Nahorski
Aluminium inhibits muscarinic agonist-induced inositol 1,4,5-trisphosphate production and calcium mobilization in permeabilized SH-SY5Y human neuroblastoma cells.
Journal of neurochemistry 1994;62(6):2219-23.
1994: R A John Challiss; Rajendra Mistry; D W Gray; Stefan R Nahorski
Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.
British journal of pharmacology 1994;112(1):231-9.
1994: R J Wojcikiewicz; Teiichi Furuichi; S Nakade; K Mikoshiba; Stefan R Nahorski
Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.
The Journal of biological chemistry 1994;269(11):7963-9.
1994: P B Simpson; R A John Challiss; Stefan R Nahorski
Potentiation of N-methyl-D-aspartate-evoked elevation of intracellular Ca2+ concentrations by exogenous glycine in cerebellar granule cells.
European journal of pharmacology 1994;266(3):309-15.
1994: R A Challis; Rajendra Mistry; D W Gray; Stefan R Nahorski
Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex.
Neuropharmacology 1994;33(1):15-25.
1993: Robert A Wilcox; E M Whitham; C Liu; B V Potter; Stefan R Nahorski
Myo-inositol 1,3,4,5-tetrakisphosphate can independently mobilise intracellular calcium, via the inositol 1,4,5-trisphosphate receptor: studies with myo-inositol 1,4,5-trisphosphate-3-phosphorothioate and myo-inositol hexakisphosphate.
FEBS letters 1993;336(2):267-71.
1993: R J Wojcikiewicz; Stefan R Nahorski
Modulation of signalling initiated by phosphoinositidase-C-linked receptors.
The Journal of experimental biology 1993;184():145-59.
1993: Robert A Wilcox; R A John Challiss; C Liu; B V Potter; Stefan R Nahorski
Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells.
Molecular pharmacology 1993;44(4):810-7.
1993: S Jenkinson; N Patel; Stefan R Nahorski; R A John Challiss
Comparative effects of lithium on the phosphoinositide cycle in rat cerebral cortex, hippocampus, and striatum.
Journal of neurochemistry 1993;61(3):1082-90.
1993: Robert A Wilcox; R A John Challiss; G Baudin; A Vasella; B V Potter; Stefan R Nahorski
Stereoselectivity of Ins(1,3,4,5)P4 recognition sites: implications for the mechanism of the Ins(1,3,4,5)P4-induced Ca2+ mobilization.
The Biochemical journal 1993;294 ( Pt 1)():191-4.
1993: P B Simpson; R A John Challiss; Stefan R Nahorski
Involvement of intracellular stores in the Ca2+ responses to N-Methyl-D-aspartate and depolarization in cerebellar granule cells.
Journal of neurochemistry 1993;61(2):760-3.
1993: R J Wojcikiewicz; Andrew B Tobin; Stefan R Nahorski
Desensitization of cell signalling mediated by phosphoinositidase C.
Trends in pharmacological sciences 1993;14(7):279-85.
1993: Andrew B Tobin; Stefan R Nahorski
Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation.
The Journal of biological chemistry 1993;268(13):9817-23.
1993: S M Smith; Stefan R Nahorski
Characterisation and distribution of inositol polyphosphate and Ryanodine receptors in the rat brain.
Journal of neurochemistry 1993;60(5):1605-14.
1993: Steve Safrany; Robert A Wilcox; C Liu; D Dubreuil; B V Potter; Stefan R Nahorski
Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor.
Molecular pharmacology 1993;43(4):499-503.
1992: I H Batty; Stefan R Nahorski
Analysis of [3H]inositol phosphate formation and metabolism in cerebral-cortical slices. Evidence for a dual metabolism of inositol 1,4-bisphosphate.
The Biochemical journal 1992;288 ( Pt 3)():807-15.
1992: Andrew B Tobin; David G Lambert; Stefan R Nahorski
Rapid desensitization of muscarinic m3 receptor-stimulated polyphosphoinositide responses.
Molecular pharmacology 1992;42(6):1042-8.
1992: S Jenkinson; R A John Challiss; Stefan R Nahorski
Evidence for lithium-sensitive inositol 4,5-bisphosphate accumulation in muscarinic cholinoceptor-stimulated cerebral-cortex slices.
The Biochemical journal 1992;287 ( Pt 2)():437-42.
1992: Robert A Wilcox; Stefan R Nahorski; D A Sawyer; C Liu; B V Potter
The role of the 2- and 3-hydroxyl groups of 1D-myo-inositol 1,4,5-trisphosphate in the mobilisation of calcium from permeabilised human 1321N1 astrocytoma cells.
Carbohydrate research 1992;234():237-46.
1992: I D Forsythe; David G Lambert; Stefan R Nahorski; P Lindsdell
Elevation of cytosolic calcium by cholinoceptor agonists in SH-SY5Y human neuroblastoma cells: estimation of the contribution of voltage-dependent currents.
British journal of pharmacology 1992;107(1):207-14.
1992: Steve Safrany; Robert A Wilcox; C Liu; B V Potter; Stefan R Nahorski
3-position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition.
European journal of pharmacology 1992;226(3):265-72.
1992: R J Wojcikiewicz; S Nakade; K Mikoshiba; Stefan R Nahorski
Inositol 1,4,5-trisphosphate receptor immunoreactivity in SH-SY5Y human neuroblastoma cells is reduced by chronic muscarinic receptor activation.
Journal of neurochemistry 1992;59(1):383-6.
1992: B V Potter; Stefan R Nahorski
Synthesis and biology of inositol polyphosphate analogues.
Biochemical Society transactions 1992;20(2):434-42.
1992: Stefan R Nahorski; S Jenkinson; R A John Challiss
Disruption of phosphoinositide signalling by lithium.
Biochemical Society transactions 1992;20(2):430-4.
1992: S Jenkinson; N Patel; Stefan R Nahorski; R A John Challiss
Quantitation of the lithium-sensitive component of the muscarinic receptor-stimulated inositol 1,3,4,5-tetrakisphosphate response in rat cerebral cortex.
Biochemical Society transactions 1992;20(2):137S.
1992: David G Lambert; R J Wojcikiewicz; Steve Safrany; E M Whitham; Stefan R Nahorski
Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells.
Progress in neuro-psychopharmacology & biological psychiatry 1992;16(3):253-70.
1992: David G Lambert; N T Burford; Stefan R Nahorski
Muscarinic receptor subtypes: inositol phosphates and intracellular calcium.
Biochemical Society transactions 1992;20(1):130-5.
1992: David G Lambert; Stefan R Nahorski
Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route?
Journal of physiology, Paris 1992;86(1-3):77-82.
1992: Stefan R Nahorski; S Jenkinson; R A John Challiss
Lithium-induced disruption of cell signalling in brain: evidence implicating the phosphoinositide cycle.
Pharmacology & toxicology 1992;71 Suppl 1():42-8.
1992: Steve Safrany; D A Sawyer; Stefan R Nahorski; B V Potter
Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: identification of a potent small molecule 3-kinase inhibitor.
Chirality 1992;4(7):415-22.
1991: R J Wojcikiewicz; Stefan R Nahorski
Chronic muscarinic stimulation of SH-SY5Y neuroblastoma cells suppresses inositol 1,4,5-trisphosphate action. Parallel inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ mobilization and inositol 1,4,5-trisphosphate binding.
The Journal of biological chemistry 1991;266(33):22234-41.
1991: R A John Challiss; Steve Safrany; B V Potter; Stefan R Nahorski
Intracellular recognition sites for inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate.
Biochemical Society transactions 1991;19(4):888-93.
1991: David G Lambert; R J Wojcikiewicz; Stefan R Nahorski
Generation and metabolism of Ins(1,4,5)P3 in SH-SY5Y human neuroblastoma cells: the regulatory role of Ca2+.
Biochemical Society transactions 1991;19(4):424S.
1991: R A John Challiss; Stefan R Nahorski
Depolarization and agonist-stimulated changes in inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate mass accumulation in rat cerebral cortex.
Journal of neurochemistry 1991;57(3):1042-51.
1991: E M Whitham; R A John Challiss; Stefan R Nahorski
Inositol 1,4,5-triphosphate-stimulated calcium release from permeabilized cerebellar granule cells.
British journal of pharmacology 1991;104(1):202-6.
1991: J G Baird; Stefan R Nahorski
Stimulatory and inhibitory effects of N-methyl-D-aspartate on 3H-inositol polyphosphate accumulation in rat cortical slices.
Journal of neurochemistry 1991;57(2):629-35.
1991: Stefan R Nahorski; C I Ragan; R A John Challiss
Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences.
Trends in pharmacological sciences 1991;12(8):297-303.
1991: G J Offer; Edwin R Chilvers; Stefan R Nahorski
Beta-adrenoceptor induced inhibition of muscarinic receptor-stimulated phosphoinositide metabolism is agonist specific in bovine tracheal smooth muscle.
European journal of pharmacology 1991;207(3):243-8.
1991: J Strupish; R J Wojcikiewicz; R A John Challiss; Steve Safrany; A L Willcocks; B V Potter; Stefan R Nahorski
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist?
The Biochemical journal 1991;277 ( Pt 1)():294.
1991: Steve Safrany; R J Wojcikiewicz; J Strupish; J McBain; A M Cooke; B V Potter; Stefan R Nahorski
Synthetic phosphorothioate-containing analogues of inositol 1,4,5-trisphosphate mobilize intracellular Ca2+ stores and interact differentially with inositol 1,4,5-trisphosphate 5-phosphatase and 3-kinase.
Molecular pharmacology 1991;39(6):754-61.
1991: J G Baird; R A John Challiss; Stefan R Nahorski
Role for ionotropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat cerebral cortex.
Molecular pharmacology 1991;39(6):745-53.
1991: D J Gawler; B V Potter; R Gigg; Stefan R Nahorski
Interactions between inositol tris- and tetrakis-phosphates. Effects on intracellular Ca2+ mobilization in SH-SY5Y cells.
The Biochemical journal 1991;276 ( Pt 1)():163-7.
1991: Edwin R Chilvers; M A Giembycz; R A John Challiss; B J Barnes; Stefan R Nahorski
Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle.
British journal of pharmacology 1991;103(1):1119-25.
1991: Edwin R Chilvers; I H Batty; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle.
The Biochemical journal 1991;275 ( Pt 2)():373-9.
1991: R A John Challiss; S M Smith; B V Potter; Stefan R Nahorski
D-[35S(U)]inositol 1,4,5-trisphosphorothioate, a novel radioligand for the inositol 1,4,5-trisphosphate receptor. Complex binding to rat cerebellar membranes.
FEBS letters 1991;281(1-2):101-4.
1991: R A John Challiss; A L Willcocks; B V Potter; Stefan R Nahorski
Comparison of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in cerebellum.
Biochemical Society transactions 1991;19(2):151S.
1991: R J Wojcikiewicz; Stefan R Nahorski
Prolonged stimulation of SH-SY5Y cells with carbachol inhibits inositol 1,4,5-trisphosphate (InsP3) binding and InsP3-induced Ca2+ mobilisation.
Biochemical Society transactions 1991;19(2):97S.
1991: Edwin R Chilvers; R A John Challiss; Stefan R Nahorski
Detection of sustained mass increases in inositol 1,3,4,5-tetrakisphosphate in agonist-stimulated airway smooth muscle.
Biochemical Society transactions 1991;19(2):76S.
1991: E M Whitham; R A John Challiss; Stefan R Nahorski
M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells.
European journal of pharmacology 1991;206(3):181-9.
1991: R A John Challiss; A L Willcocks; B Mulloy; B V Potter; Stefan R Nahorski
Characterization of inositol 1,4,5-trisphosphate- and inositol 1,3,4,5-tetrakisphosphate-binding sites in rat cerebellum.
The Biochemical journal 1991;274 ( Pt 3)():861-7.
1991: David G Lambert; R A John Challiss; Stefan R Nahorski
Accumulation and metabolism of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in muscarinic-receptor-stimulated SH-SY5Y neuroblastoma cells.
The Biochemical journal 1991;273 ( Pt 3)():791-4.
1991: Steve Safrany; R J Wojcikiewicz; J Strupish; Stefan R Nahorski; D Dubreuil; J Cleophax; S D Gero; B V Potter
Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2(+)-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase.
FEBS letters 1991;278(2):252-6.
1990: Steve Safrany; D Sawyer; R J Wojcikiewicz; Stefan R Nahorski; B V Potter
Ca2(+)-mobilising properties of synthetic fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction with myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase.
FEBS letters 1990;276(1-2):91-4.
1990: D J Gawler; B V Potter; Stefan R Nahorski
Inositol 1,3,4,5-tetrakisphosphate-induced release of intracellular Ca2+ in SH-SY5Y neuroblastoma cells.
The Biochemical journal 1990;272(2):519-24.
1990: R J Wojcikiewicz; Steve Safrany; R A John Challiss; J Strupish; Stefan R Nahorski
Coupling of muscarinic receptors to the mobilization of intracellular Ca2+ stores in permeabilized SH-SY5Y human neuroblastoma cells.
The Biochemical journal 1990;272(1):269-72.
1990: David G Lambert; Stefan R Nahorski
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
Biochemical pharmacology 1990;40(10):2291-5.
1990: A L Willcocks; R A John Challiss; Stefan R Nahorski
Characteristics of inositol 1,4,5-trisphosphate binding to rat cerebellar and bovine adrenal cortical membranes: evidence for the heterogeneity of binding sites.
European journal of pharmacology 1990;189(2-3):185-93.
1990: R J Wojcikiewicz; A M Cooke; B V Potter; Stefan R Nahorski
Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate.
European journal of biochemistry / FEBS 1990;192(2):459-67.
1990: David G Lambert; E M Whitham; J G Baird; Stefan R Nahorski
Different mechanisms of Ca2+ entry induced by depolarization and muscarinic receptor stimulation in SH-SY5Y human neuroblastoma cells.
Brain research. Molecular brain research 1990;8(3):263-6.
1990: R A John Challiss; Stefan R Nahorski
Neurotransmitter and depolarization-stimulated accumulation of inositol 1,3,4,5-tetrakisphosphate mass in rat cerebral cortex slices.
Journal of neurochemistry 1990;54(6):2138-41.
1990: J G Baird; Stefan R Nahorski
Differences between muscarinic-receptor- and Ca2(+)-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices.
The Biochemical journal 1990;267(3):835-8.
1990: E D Kennedy; R A John Challiss; C I Ragan; Stefan R Nahorski
Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices.
The Biochemical journal 1990;267(3):781-6.
1990: Edwin R Chilvers; Stefan R Nahorski
Phosphoinositide metabolism in airway smooth muscle.
The American review of respiratory disease 1990;141(3 Pt 2):S137-40.
1990: Edwin R Chilvers; I H Batty; Peter J Barnes; Stefan R Nahorski
Formation of inositol polyphosphates in airway smooth muscle after muscarinic receptor stimulation.
The Journal of pharmacology and experimental therapeutics 1990;252(2):786-91.
1990: J G Baird; Stefan R Nahorski
Increased intracellular calcium stimulates 3H-inositol polyphosphate accumulation in rat cerebral cortical slices.
Journal of neurochemistry 1990;54(2):555-61.
1990: Edwin R Chilvers; R A John Challiss; A L Willcocks; B V Potter; Peter J Barnes; Stefan R Nahorski
Characterisation of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle.
British journal of pharmacology 1990;99(2):297-302.
1990: R J Wojcikiewicz; David G Lambert; Stefan R Nahorski
Regulation of muscarinic agonist-induced activation of phosphoinositidase C in electrically permeabilized SH-SY5Y human neuroblastoma cells by guanine nucleotides.
Journal of neurochemistry 1990;54(2):676-85.
1990: David G Lambert; Stefan R Nahorski
Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y.
The Biochemical journal 1990;265(2):555-62.
1990: R A John Challiss; Edwin R Chilvers; A L Willcocks; Stefan R Nahorski
Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay.
The Biochemical journal 1990;265(2):421-7.
1990: Stefan R Nahorski
Receptors, inositol polyphosphates and intracellular Ca2+.
British journal of clinical pharmacology 1990;30 Suppl 1():23S-26S.
1990: David G Lambert; Stefan R Nahorski
Second-messenger responses associated with stimulation of neuronal muscarinic receptors expressed by a human neuroblastoma SH-SY5Y.
Progress in brain research 1990;84():31-42.
1990: Johan Zaagsma; Stefan R Nahorski
Is the adipocyte beta-adrenoceptor a prototype for the recently cloned atypical 'beta 3-adrenoceptor'?
Trends in pharmacological sciences 1990;11(1):3-7.
1989: T A Rooney; Stefan R Nahorski
Developmental aspects of muscarinic-induced inositol polyphosphate accumulation in rat cerebral cortex.
European journal of pharmacology 1989;172(6):425-34.
1989: Edwin R Chilvers; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Characterization of stereospecific binding sites for [3H]-inositol (1,4,5)-trisphosphate in airway smooth muscle.
British journal of pharmacology 1989;98 Suppl():787P.
1989: J G Baird; David G Lambert; J McBain; Stefan R Nahorski
Muscarinic receptors coupled to phosphoinositide hydrolysis and elevated cytosolic calcium in a human neuroblastoma cell line SK-N-SH.
British journal of pharmacology 1989;98(4):1328-34.
1989: E D Kennedy; R A John Challiss; Stefan R Nahorski
Lithium reduces the accumulation of inositol polyphosphate second messengers following cholinergic stimulation of cerebral cortex slices.
Journal of neurochemistry 1989;53(5):1652-5.
1989: Edwin R Chilvers; Peter J Barnes; Stefan R Nahorski
Characterization of agonist-stimulated incorporation of myo-[3H]inositol into inositol phospholipids and [3H]inositol phosphate formation in tracheal smooth muscle.
The Biochemical journal 1989;262(3):739-46.
1989: J G Baird; Stefan R Nahorski
Dual effects of K+ depolarisation on inositol polyphosphate production in rat cerebral cortex.
Journal of neurochemistry 1989;53(3):681-5.
1989: David G Lambert; A S Ghataorre; Stefan R Nahorski
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
European journal of pharmacology 1989;165(1):71-7.
1989: Edwin R Chilvers; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Mass changes of inositol(1,4,5)trisphosphate in trachealis muscle following agonist stimulation.
European journal of pharmacology 1989;164(3):587-90.
1989: E D Kennedy; I H Batty; Edwin R Chilvers; Stefan R Nahorski
A simple enzymic method to separate [3H]inositol 1,4,5- and 1,3,4-trisphosphate isomers in tissue extracts.
The Biochemical journal 1989;260(1):283-6.
1989: I H Batty; Stefan R Nahorski
Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation.
The Biochemical journal 1989;260(1):237-41.
1989: R J Wojcikiewicz; Stefan R Nahorski
Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan.
FEBS letters 1989;247(2):341-4.
1989: J G Baird; Edwin R Chilvers; E D Kennedy; Stefan R Nahorski
Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(3):247-51.
1989: I H Batty; A J Letcher; Stefan R Nahorski
Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations.
The Biochemical journal 1989;258(1):23-32.
1989: A M Cooke; Stefan R Nahorski; B V Potter
myo-inositol 1,4,5-trisphosphorothioate is a potent competitive inhibitor of human erythrocyte 5-phosphatase.
FEBS letters 1989;242(2):373-7.
1989: A L Willcocks; J Strupish; R F Irvine; Stefan R Nahorski
Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors.
The Biochemical journal 1989;257(1):297-300.
1988: R A John Challiss; I H Batty; Stefan R Nahorski
Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization.
Biochemical and biophysical research communications 1988;157(2):684-91.
1988: M Keen; Stefan R Nahorski
Muscarinic acetylcholine receptors linked to the inhibition of adenylate cyclase activity in membranes from the rat striatum and myocardium can be distinguished on the basis of agonist efficacy.
Molecular pharmacology 1988;34(6):769-78.
1988: B Ek; Stefan R Nahorski
Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle.
Biochemical pharmacology 1988;37(23):4461-7.
1988: A L Willcocks; B V Potter; A M Cooke; Stefan R Nahorski
Myo-inositol(1,4,5)trisphosphorothioate binds to specific [3H]inositol(1,4,5)trisphosphate sites in rat cerebellum and is resistant to 5-phosphatase.
European journal of pharmacology 1988;155(1-2):181-3.
1988: E Kelly; I Batty; Stefan R Nahorski
Dopamine receptor stimulation does not affect phosphoinositide hydrolysis in slices of rat striatum.
Journal of neurochemistry 1988;51(3):918-24.
1988: J Strupish; A M Cooke; B V Potter; R Gigg; Stefan R Nahorski
Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-triphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate.
The Biochemical journal 1988;253(3):901-5.
1988: N Cook; Stefan R Nahorski; C Jagger; D B Barnett
Is the human platelet beta 2 adrenoceptor coupled to adenylate cyclase?
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(2):238-40.
1987: I Batty; Stefan R Nahorski
Lithium inhibits muscarinic-receptor-stimulated inositol tetrakisphosphate accumulation in rat cerebral cortex.
The Biochemical journal 1987;247(3):797-800.
1987: N Cook; Stefan R Nahorski; D B Barnett
Human platelet beta 2-adrenoceptors: agonist-induced internalisation and down-regulation in intact cells.
British journal of pharmacology 1987;92(3):587-96.
1987: T A Rooney; Stefan R Nahorski
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
The Journal of pharmacology and experimental therapeutics 1987;243(1):333-41.
1987: A L Willcocks; A M Cooke; B V Potter; Stefan R Nahorski
Stereospecific recognition sites for [3H]inositol(1,4,5)-triphosphate in particulate preparations of rat cerebellum.
Biochemical and biophysical research communications 1987;146(3):1071-8.