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Hironobu Naiki

Research Profile

Chemicals & Drugs

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Kotaro Yanagi; Yuichi Yoshimura; Takahisa Ikegami; Tsuyoshi Konuma; Young-Ho Lee; Hironobu Naiki; Kazumasa Sakurai; Kenji Sugase; Yuji Goto
The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques.
Yuichi Yoshimura; Hiroki Kitayama; Young-Ho Lee; Yuxi Lin; Hironobu Naiki; Hirotsugu Ogi; Kazumasa Sakurai; Masatomo So; Hisashi Yagi; Yuji Goto
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.
Naoki Takahashi; Shouji Tsutaya; Minoru Yasujima; Seiji Yokoi; Masanori Hara; Yoshiaki Hirayama; Masayuki Iwano; Kenji Kasuno; Hideki Kimura; Hiroyuki Kurosawa; Daisuke Mikami; Shinichi Mizuno; Hironobu Naiki; Haruyoshi Yoshida
Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient.

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2012: Kotaro Yanagi; Yuichi Yoshimura; Takahisa Ikegami; Tsuyoshi Konuma; Young-Ho Lee; Hironobu Naiki; Kazumasa Sakurai; Kenji Sugase; Yuji Goto
The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques.
Journal of molecular biology 2012;422(3):390-402.
2012: Yuichi Yoshimura; Hiroki Kitayama; Young-Ho Lee; Yuxi Lin; Hironobu Naiki; Hirotsugu Ogi; Kazumasa Sakurai; Masatomo So; Hisashi Yagi; Yuji Goto
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14446-51.
2012: Naoki Takahashi; Shouji Tsutaya; Minoru Yasujima; Seiji Yokoi; Masanori Hara; Yoshiaki Hirayama; Masayuki Iwano; Kenji Kasuno; Hideki Kimura; Hiroyuki Kurosawa; Daisuke Mikami; Shinichi Mizuno; Hironobu Naiki; Haruyoshi Yoshida
Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient.
Clinical and experimental nephrology 2012;16(3):495-500.
2012: Akiko Kawakita; Mitsufumi Mayumi; Hironobu Naiki; Hisako Shirasaki; Shuko Tokuriki; Motoko Yasutomi; Yusei Ohshima
Immunotherapy with oligomannose-coated liposomes ameliorates allergic symptoms in a murine food allergy model.
Allergy 2012;67(3):371-9.
2012: Asako Ueno; Makoto Yoneda; Yuiti Kimura; Hironobu Naiki; Tadakazu Ookoshi; Masaru Kuriyama
[An autopsied case of zygomycosis invasing in the central nervous system and vessels, which is difficult in the differential diagnosis from aspergillosis].
Rinshō shinkeigaku = Clinical neurology 2012;52(2):84-9.
2011: Masatomo So; Hisashi Yagi; Hironobu Naiki; Hirotsugu Ogi; Kazumasa Sakurai; Yuji Goto
Ultrasonication-dependent acceleration of amyloid fibril formation.
Journal of molecular biology 2011;412(4):568-77.
2011: Naoki Takahashi; Haruyoshi Yoshida; Hideki Kimura; Hironobu Naiki
[III. Paraproteinemia: 2. Amyloidosis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(5):1282-8.
2011: Daisaku Ozawa; Yuichi Kaji; Hisashi Yagi; Kazumasa Sakurai; Toru Kawakami; Hironobu Naiki; Yuji Goto
Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T.
The Journal of biological chemistry 2011;286(12):10856-63.
2011: Daisaku Ozawa; Kazuhiro Hasegawa; Young-Ho Lee; Kazumasa Sakurai; Kotaro Yanagi; Tadakazu Ookoshi; Yuji Goto; Hironobu Naiki
Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin.
The Journal of biological chemistry 2011;286(11):9668-76.
2011: Tsuyoshi Konuma; Eri Chatani; Masanori Yagi; Kazumasa Sakurai; Takahisa Ikegami; Hironobu Naiki; Yuji Goto
Kinetic intermediates of β(2)-microglobulin fibril elongation probed by pulse-labeling H/D exchange combined with NMR analysis.
Journal of molecular biology 2011;405(3):851-62.
2010: Yuichi Yoshimura; Kazumasa Sakurai; Young-Ho Lee; Takahisa Ikegami; Eri Chatani; Hironobu Naiki; Yuji Goto
Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy.
Protein science : a publication of the Protein Society 2010;19(12):2347-55.
2010: Kaori Yamamoto; Hisashi Yagi; Young-Ho Lee; József Kardos; Yoshihisa Hagihara; Hironobu Naiki; Yuji Goto
The amyloid fibrils of the constant domain of immunoglobulin light chain.
FEBS letters 2010;584(15):3348-53.
2010: Eri Chatani; Reina Ohnishi; Tsuyoshi Konuma; Kazumasa Sakurai; Hironobu Naiki; Yuji Goto
Pre-steady-state kinetic analysis of the elongation of amyloid fibrils of beta(2)-microglobulin with tryptophan mutagenesis.
Journal of molecular biology 2010;400(5):1057-66.
2010: Hisashi Yagi; Daisaku Ozawa; Kazumasa Sakurai; Toru Kawakami; Hiroki Kuyama; Osamu Nishimura; Toshinori Shimanouchi; Ryoichi Kuboi; Hironobu Naiki; Yuji Goto
Laser-induced propagation and destruction of amyloid beta fibrils.
The Journal of biological chemistry 2010;285(25):19660-7.
2010: Hironobu Naiki; Kazuhiro Hasegawa; Kenjiro Ono; Masahito Yamada
[Search for antiamyloidogenic compounds based on a nucleation-dependent polymerization model].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(4):503-9.
2010: Akiyoshi Morinaga; Kazuhiro Hasegawa; Ryo Nomura; Tadakazu Ookoshi; Daisaku Ozawa; Yuji Goto; Masahito Yamada; Hironobu Naiki
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Biochimica et biophysica acta 2010;1804(4):986-95.
2009: Hironobu Naiki; Yoshitaka Nagai
Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins.
Journal of biochemistry 2009;146(6):751-6.
2009: Masamichi Ikawa; Makoto Yoneda; Akiko Matsunaga; Hiroto Nakagawa; Asuka Kazama-Suzuki; Nobuo Miyashita; Hironobu Naiki; Tetsuyuki Kitamoto; Masaru Kuriyama
Unique clinicopathological features and PrP profiles in the first autopsied case of dura mater graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population.
Journal of the neurological sciences 2009;285(1-2):265-7.
2009: Satoshi Ikegaya; Kunihiro Inai; Hiromichi Iwasaki; Hironobu Naiki; Takanori Ueda
Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathway.
Journal of chemotherapy (Florence, Italy) 2009;21(4):396-402.
2009: Atsushi Kameda; Eugene Hayato Morita; Kazumasa Sakurai; Hironobu Naiki; Yuji Goto
NMR-based characterization of a refolding intermediate of beta2-microglobulin labeled using a wheat germ cell-free system.
Protein science : a publication of the Protein Society 2009;18(8):1592-601.
2009: Eri Chatani; Young-Ho Lee; Hisashi Yagi; Yuichi Yoshimura; Hironobu Naiki; Yuji Goto
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11119-24.
2009: Kenji Sasahara; Hisashi Yagi; Hironobu Naiki; Yuji Goto
Thermal response with exothermic effects of beta2-microglobulin amyloid fibrils and fibrillation.
Journal of molecular biology 2009;389(3):584-94.
2009: Hirofumi Misaki; Takahiro Yamauchi; Hajime Arai; Shuji Yamamoto; Hidemasa Sutoh; Akira Yoshida; Hiroshi Tsutani; Manabu Eguchi; Haruhisa Nagoshi; Hironobu Naiki; Hisatoshi Baba; Takanori Ueda; Mitsunori Yamakawa
Secondary malignant fibrous histiocytoma following refractory langerhans cell histiocytosis.
Journal of clinical and experimental hematopathology : JCEH 2009;49(1):33-7.
2009: Akiko Yamada; Yusei Ohshima; Motoko Yasutomi; Kazumasa Ogura; Shuko Tokuriki; Hironobu Naiki; Mitsufumi Mayumi
Antigen-primed splenic CD8+ T cells impede the development of oral antigen-induced allergic diarrhea.
The Journal of allergy and clinical immunology 2009;123(4):889-94.
2009: Young-Ho Lee; Eri Chatani; Kenji Sasahara; Hironobu Naiki; Yuji Goto
A comprehensive model for packing and hydration for amyloid fibrils of beta2-microglobulin.
The Journal of biological chemistry 2009;284(4):2169-75.
2009: Daisaku Ozawa; Hisashi Yagi; Tadato Ban; Atsushi Kameda; Toru Kawakami; Hironobu Naiki; Yuji Goto
Destruction of amyloid fibrils of a beta2-microglobulin fragment by laser beam irradiation.
The Journal of biological chemistry 2009;284(2):1009-17.
2008: Kazuhiro Hasegawa; Shinobu Tsutsumi-Yasuhara; Tadakazu Ookoshi; Yumiko Ohhashi; Hideki Kimura; Naoki Takahashi; Haruyoshi Yoshida; Ryoichi Miyazaki; Yuji Goto; Hironobu Naiki
Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH.
The Biochemical journal 2008;416(2):307-15.
2008: Michiko Sakata; Eri Chatani; Atsushi Kameda; Kazumasa Sakurai; Hironobu Naiki; Yuji Goto
Kinetic coupling of folding and prolyl isomerization of beta2-microglobulin studied by mutational analysis.
Journal of molecular biology 2008;382(5):1242-55.
2008: Tadakazu Ookoshi; Kazuhiro Hasegawa; Yumiko Ohhashi; Hideki Kimura; Naoki Takahashi; Haruyoshi Yoshida; Ryoichi Miyazaki; Yuji Goto; Hironobu Naiki
Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(10):3247-55.
2008: Kunihiro Inai; Kazutaka Takagi; Nobuo Takimoto; Hiromi Okada; Yoshiaki Imamura; Takanori Ueda; Hironobu Naiki; Sakon Noriki
Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma.
Cancer science 2008;99(9):1778-84.
2008: Kenji Sasahara; Hisashi Yagi; Miyo Sakai; Hironobu Naiki; Yuji Goto
Amyloid nucleation triggered by agitation of beta2-microglobulin under acidic and neutral pH conditions.
Biochemistry 2008;47(8):2650-60.
2008: Kaori Yamamoto; Hisashi Yagi; Daisaku Ozawa; Kenji Sasahara; Hironobu Naiki; Yuji Goto
Thiol compounds inhibit the formation of amyloid fibrils by beta 2-microglobulin at neutral pH.
Journal of molecular biology 2008;376(1):258-68.
2007: Hisashi Yagi; Tadato Ban; Kenichi Morigaki; Hironobu Naiki; Yuji Goto
Visualization and classification of amyloid beta supramolecular assemblies.
Biochemistry 2007;46(51):15009-17.
2007: Kenji Sasahara; Hisashi Yagi; Hironobu Naiki; Yuji Goto
Heat-induced conversion of beta(2)-microglobulin and hen egg-white lysozyme into amyloid fibrils.
Journal of molecular biology 2007;372(4):981-91.
2007: Yoshitaka Nagai; Takashi Inui; H Akiko Popiel; Nobuhiro Fujikake; Kazuhiro Hasegawa; Yoshihiro Urade; Yuji Goto; Hironobu Naiki; Tatsushi Toda
A toxic monomeric conformer of the polyglutamine protein.
Nature structural & molecular biology 2007;14(4):332-40.
2007: Rumi Adachi; Kei-ichi Yamaguchi; Hisashi Yagi; Kazumasa Sakurai; Hironobu Naiki; Yuji Goto
Flow-induced alignment of amyloid protofilaments revealed by linear dichroism.
The Journal of biological chemistry 2007;282(12):8978-83.
2007: Kenji Sasahara; Hisashi Yagi; Hironobu Naiki; Yuji Goto
Heat-triggered conversion of protofibrils into mature amyloid fibrils of beta2-microglobulin.
Biochemistry 2007;46(11):3286-93.
2007: Mie Hirohata; Kazuhiro Hasegawa; Shinobu Tsutsumi-Yasuhara; Yumiko Ohhashi; Tadakazu Ookoshi; Kenjiro Ono; Masahito Yamada; Hironobu Naiki
The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure.
Biochemistry 2007;46(7):1888-99.
2006: Kentaro Iwata; Toshimichi Fujiwara; Yasushi Matsuki; Hideo Akutsu; Satoshi Takahashi; Hironobu Naiki; Yuji Goto
3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18119-24.
2006: Tadato Ban; Kenichi Morigaki; Hisashi Yagi; Takashi Kawasaki; Atsuko Kobayashi; Shunsuke Yuba; Hironobu Naiki; Yuji Goto
Real-time and single fibril observation of the formation of amyloid beta spherulitic structures.
The Journal of biological chemistry 2006;281(44):33677-83.
2006: Kei-ichi Yamaguchi; Hironobu Naiki; Yuji Goto
Mechanism by which the amyloid-like fibrils of a beta 2-microglobulin fragment are induced by fluorine-substituted alcohols.
Journal of molecular biology 2006;363(1):279-88.
2006: Miho Kihara; Eri Chatani; Kentaro Iwata; Kaori Yamamoto; Takanori Matsuura; Atsushi Nakagawa; Hironobu Naiki; Yuji Goto
Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis.
The Journal of biological chemistry 2006;281(41):31061-9.
2006: Kenji Sasahara; Hironobu Naiki; Yuji Goto
Exothermic effects observed upon heating of beta2-microglobulin monomers in the presence of amyloid seeds.
Biochemistry 2006;45(29):8760-9.
2006: Eri Chatani; Hironobu Naiki; Yuji Goto
Seeding-dependent propagation and maturation of beta2-microglobulin amyloid fibrils under high pressure.
Journal of molecular biology 2006;359(4):1086-96.
2005: Bakthisaran Raman; Tadato Ban; Miyo Sakai; Saloni Yatin Pasta; Tangirala Ramakrishna; Hironobu Naiki; Yuji Goto; Ch Mohan Rao
AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin.
The Biochemical journal 2005;392(Pt 3):573-81.
2005: Kei-Ichi Yamaguchi; Satoshi Takahashi; Tomoji Kawai; Hironobu Naiki; Yuji Goto
Seeding-dependent propagation and maturation of amyloid fibril conformation.
Journal of molecular biology 2005;352(4):952-60.
2005: Eri Chatani; Michiko Kato; Tomoji Kawai; Hironobu Naiki; Yuji Goto
Main-chain dominated amyloid structures demonstrated by the effect of high pressure.
Journal of molecular biology 2005;352(4):941-51.
2005: Kenji Sasahara; Hironobu Naiki; Yuji Goto
Kinetically controlled thermal response of beta2-microglobulin amyloid fibrils.
Journal of molecular biology 2005;352(3):700-11.
2005: Yumiko Ohhashi; Miho Kihara; Hironobu Naiki; Yuji Goto
Ultrasonication-induced amyloid fibril formation of beta2-microglobulin.
The Journal of biological chemistry 2005;280(38):32843-8.
2005: Atsushi Kameda; Masaru Hoshino; Takashi Higurashi; Satoshi Takahashi; Hironobu Naiki; Yuji Goto
Nuclear magnetic resonance characterization of the refolding intermediate of beta2-microglobulin trapped by non-native prolyl peptide bond.
Journal of molecular biology 2005;348(2):383-97.
2005: Bakthisaran Raman; Tadato Ban; Kei-Ichi Yamaguchi; Miyo Sakai; Tomoji Kawai; Hironobu Naiki; Yuji Goto
Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide.
The Journal of biological chemistry 2005;280(16):16157-62.
2005: Miho Kihara; Eri Chatani; Miyo Sakai; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Seeding-dependent maturation of beta2-microglobulin amyloid fibrils at neutral pH.
The Journal of biological chemistry 2005;280(12):12012-8.
2005: Hironobu Naiki; Suguru Yamamoto; Kazuhiro Hasegawa; Itaru Yamaguchi; Yuji Goto; Fumitake Gejyo
Molecular interactions in the formation and deposition of beta2-microglobulin-related amyloid fibrils.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2005;12(1):15-25.
2005: Takashi Kanno; Keiichi Yamaguchi; Hironobu Naiki; Yuji Goto; Tomoji Kawai
Association of thin filaments into thick filaments revealing the structural hierarchy of amyloid fibrils.
Journal of structural biology 2005;149(2):213-8.
2005: Bakthisaran Raman; Eri Chatani; Miho Kihara; Tadato Ban; Miyo Sakai; Kazuhiro Hasegawa; Hironobu Naiki; Ch Mohan Rao; Yuji Goto
Critical balance of electrostatic and hydrophobic interactions is required for beta 2-microglobulin amyloid fibril growth and stability.
Biochemistry 2005;44(4):1288-99.
2005: Hiromasa Wadai; Kei-ichi Yamaguchi; Satoshi Takahashi; Takashi Kanno; Tomoji Kawai; Hironobu Naiki; Yuji Goto
Stereospecific amyloid-like fibril formation by a peptide fragment of beta2-microglobulin.
Biochemistry 2005;44(1):157-64.
2004: József Kardos; Kaori Yamamoto; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Direct measurement of the thermodynamic parameters of amyloid formation by isothermal titration calorimetry.
The Journal of biological chemistry 2004;279(53):55308-14.
2004: Tadato Ban; Masaru Hoshino; Satoshi Takahashi; Daizo Hamada; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Direct observation of Abeta amyloid fibril growth and inhibition.
Journal of molecular biology 2004;344(3):757-67.
2004: Takashi Konno; Shigetoshi Oiki; Kazuhiro Hasegawa; Hironobu Naiki
Anionic contribution for fibrous maturation of protofibrillar assemblies of the human tau repeat domain in a fluoroalcohol solution.
Biochemistry 2004;43(42):13613-20.
2004: Takehiro Narimoto; Kazumasa Sakurai; Azusa Okamoto; Eri Chatani; Masaru Hoshino; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Conformational stability of amyloid fibrils of beta2-microglobulin probed by guanidine-hydrochloride-induced unfolding.
FEBS letters 2004;576(3):313-9.
2004: Suguru Yamamoto; Kazuhiro Hasegawa; Itaru Yamaguchi; Shinobu Tsutsumi; József Kardos; Yuji Goto; Fumitake Gejyo; Hironobu Naiki
Low concentrations of sodium dodecyl sulfate induce the extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH.
Biochemistry 2004;43(34):11075-82.
2004: Kei-ichi Yamaguchi; Hidenori Katou; Masaru Hoshino; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Core and heterogeneity of beta2-microglobulin amyloid fibrils as revealed by H/D exchange.
Journal of molecular biology 2004;338(3):559-71.
2004: Yumiko Ohhashi; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Optimum amyloid fibril formation of a peptide fragment suggests the amyloidogenic preference of beta2-microglobulin under physiological conditions.
The Journal of biological chemistry 2004;279(11):10814-21.
2004: James Villanueva; Masaru Hoshino; Hidenori Katou; József Kardos; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Increase in the conformational flexibility of beta 2-microglobulin upon copper binding: a possible role for copper in dialysis-related amyloidosis.
Protein science : a publication of the Protein Society 2004;13(3):797-809.
2004: Suguru Yamamoto; Itaru Yamaguchi; Kazuhiro Hasegawa; Shinobu Tsutsumi; Yuji Goto; Fumitake Gejyo; Hironobu Naiki
Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH.
Journal of the American Society of Nephrology : JASN 2004;15(1):126-33.
2003: Takeshi Chiba; Yoshihisa Hagihara; Takashi Higurashi; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin.
The Journal of biological chemistry 2003;278(47):47016-24.
2003: Itaru Yamaguchi; Hironori Suda; Naoki Tsuzuike; Kouichi Seto; Masaharu Seki; Yukiya Yamaguchi; Kazuhiro Hasegawa; Naoki Takahashi; Suguru Yamamoto; Fumitake Gejyo; Hironobu Naiki
Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro.
Kidney international 2003;64(3):1080-8.
2003: Nami Hirota-Nakaoka; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Dissolution of beta2-microglobulin amyloid fibrils by dimethylsulfoxide.
Journal of biochemistry 2003;134(1):159-64.
2003: Masayo Gozu; Young Ho Lee; Yumiko Ohhashi; Masaru Hoshino; Hironobu Naiki; Yuji Goto
Conformational dynamics of beta(2)-microglobulin analyzed by reduction and reoxidation of the disulfide bond.
Journal of biochemistry 2003;133(6):731-6.
2003: Tadato Ban; Daizo Hamada; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence.
The Journal of biological chemistry 2003;278(19):16462-5.
2003: Masaki Mori; Yoshiaki Imamura; Hideki Maegawa; Haruyoshi Yoshida; Hironobu Naiki; Masaru Fukuda
Cytology of pleural effusion associated with disseminated infection caused by varicella-zoster virus in an immunocompromised patient. A case report.
Acta cytologica 2003;47(3):480-4.
2003: Satoshi Ikegaya; Akira Yoshida; Hiromichi Iwasaki; Hironobu Naiki; Takanori Ueda
Esophageal erosion as a possible bacterial entry site in an acute lymphoblastic leukemia patient with sepsis.
International journal of hematology 2003;77(4):395-8.
2003: Kazuhiro Hasegawa; Yumiko Ohhashi; Itaru Yamaguchi; Naoki Takahashi; Shinobu Tsutsumi; Yuji Goto; Fumitake Gejyo; Hironobu Naiki
Amyloidogenic synthetic peptides of beta2-microglobulin--a role of the disulfide bond.
Biochemical and biophysical research communications 2003;304(1):101-6.
2003: Momoyo Asahi; Yukie Tanaka; Toshimasa Izumi; Yoshiyuki Ito; Hironobu Naiki; Dangeruta Kersulyte; Kazutake Tsujikawa; Masakazu Saito; Kiyonao Sada; Shigeru Yanagi; Akihiro Fujikawa; Masaharu Noda; Yoshinori Itokawa
Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo.
Helicobacter 2003;8(1):1-14.
2002: Isamu Mori; Beixing Liu; Md Jaber Hossain; Hiroki Takakuwa; Tohru Daikoku; Yukihiro Nishiyama; Hironobu Naiki; Kazuo Matsumoto; Takashi Yokochi; Yoshinobu Kimura
Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice.
Virology 2002;303(2):287-96.
2002: Naoki Takahashi; Kazuhiro Hasegawa; Itaru Yamaguchi; Hiromi Okada; Takanori Ueda; Fumitake Gejyo; Hironobu Naiki
Establishment of a first-order kinetic model of light chain-associated amyloid fibril extension in vitro.
Biochimica et biophysica acta 2002;1601(1):110-20.
2002: Kazuhiro Hasegawa; Kenjiro Ono; Masahito Yamada; Hironobu Naiki
Kinetic modeling and determination of reaction constants of Alzheimer's beta-amyloid fibril extension and dissociation using surface plasmon resonance.
Biochemistry 2002;41(46):13489-98.
2002: Kenjiro Ono; Kazuhiro Hasegawa; Masahito Yamada; Hironobu Naiki
Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro.
Biological psychiatry 2002;52(9):880-6.
2002: Hidenori Katou; Takashi Kanno; Masaru Hoshino; Yoshihisa Hagihara; Hiroyuki Tanaka; Tomoji Kawai; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR.
Protein science : a publication of the Protein Society 2002;11(9):2218-29.
2002: Dong-Pyo Hong; Masayo Gozu; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Conformation of beta 2-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond.
The Journal of biological chemistry 2002;277(24):21554-60.
2002: Kenjiro Ono; Kazuhiro Hasegawa; Yuji Yoshiike; Akihiko Takashima; Masahito Yamada; Hironobu Naiki
Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.
Journal of neurochemistry 2002;81(3):434-40.
2002: Masaru Hoshino; Hidenori Katou; Yoshihisa Hagihara; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange.
Nature structural biology 2002;9(5):332-6.
2002: Takahiro Yamauchi; Hirofumi Misaki; Hajime Arai; Hiromichi Iwasaki; Hironobu Naiki; Takanori Ueda
An autopsy case of disseminated mucormycosis in a neutropenic patient receiving chemotherapy for the underlying solid malignancy.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2002;8(1):103-5.
2002: Gennady V Kozhukh; Yoshihisa Hagihara; Toru Kawakami; Kazuhiro Hasegawa; Hironobu Naiki; Yuji Goto
Investigation of a peptide responsible for amyloid fibril formation of beta 2-microglobulin by achromobacter protease I.
The Journal of biological chemistry 2002;277(2):1310-5.
2002: Yumiko Ohhashi; Yoshihisa Hagihara; Gennady V Kozhukh; Masaru Hoshino; Kazuhiro Hasegawa; Itaru Yamaguchi; Hironobu Naiki; Yuji Goto
The intrachain disulfide bond of beta(2)-microglobulin is not essential for the immunoglobulin fold at neutral pH, but is essential for amyloid fibril formation at acidic pH.
Journal of biochemistry 2002;131(1):45-52.
2001: Itaru Yamaguchi; Kazuhiro Hasegawa; Naoki Takahashi; Fumitake Gejyo; Hironobu Naiki
Apolipoprotein E inhibits the depolymerization of beta 2-microglobulin-related amyloid fibrils at a neutral pH.
Biochemistry 2001;40(29):8499-507.
2001: Itaru Yamaguchi; Kazuhiro Hasegawa; Hironobu Naiki; T Mitsu; Y Matuo; Fumitake Gejyo
Extension of A beta2M amyloid fibrils with recombinant human beta2-microglobulin.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(1):30-40.
2000: Shinji Kishi; Akira Yoshida; Takahiro Yamauchi; Hiroshi Tsutani; J D Lee; Toshiaki Nakamura; Hironobu Naiki; Takanori Ueda
Torsade de pointes associated with hypokalemia after anthracycline treatment in a patient with acute lymphocytic leukemia.
International journal of hematology 2000;71(2):172-9.
1999: N Hashimoto; Hironobu Naiki; Fumitake Gejyo
Modification of beta 2-microglobulin with D-glucose or 3-deoxyglucosone inhibits A beta 2M amyloid fibril extension in vitro.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(4):256-64.
1999: Kazuhiro Hasegawa; Itaru Yamaguchi; S Omata; Fumitake Gejyo; Hironobu Naiki
Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.
Biochemistry 1999;38(47):15514-21.
1999: Hiroshi Tsutani; Kunihiro Inai; Shinji Kishi; Kenji Morinaga; Hironobu Naiki; Takanori Ueda
Hepatic tumor rupture following effectual treatment with irinotecan in a patient with highly refractory malignant lymphoma.
International journal of hematology 1999;70(3):178-80.
1999: Hironobu Naiki; F Gejyo
Kinetic analysis of amyloid fibril formation.
Methods in enzymology 1999;309():305-18.
1998: Hironobu Naiki; Kazuhiro Hasegawa; Itaru Yamaguchi; H Nakamura; Fumitake Gejyo; K Nakakuki
Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro.
Biochemistry 1998;37(51):17882-9.
1998: Hiroshi Tada; K Asazuma; Hironobu Naiki; T Nakai; K Nakakuki
Metastatic tumor thrombus attached to a pacemaker electrode.
Pacing and clinical electrophysiology : PACE 1998;21(11 Pt 1):2143-6.
1997: Fumitake Gejyo; Hideki Kimura; Satoru Suzuki; Ryoichi Miyazaki; Hironobu Naiki; K Nakakuki
Apolipoprotein E and alpha 1-antichymotrypsin in dialysis-related amyloidosis.
Kidney international. Supplement 1997;62():S75-8.
1997: Hironobu Naiki; Fumitake Gejyo; K Nakakuki
Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro.
Biochemistry 1997;36(20):6243-50.
1996: Hironobu Naiki; K Nakakuki
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
Laboratory investigation; a journal of technical methods and pathology 1996;74(2):374-83.
1995: Y Koshimoto; M Maeda; Hironobu Naiki; K Nakakuki; Y Ishii
MR of pituitary metastasis in a patient with diabetes insipidus.
AJNR. American journal of neuroradiology 1995;16(4 Suppl):971-4.
1993: K Anwar; K Nakakuki; H Imai; Hironobu Naiki; Manabu Inuzuka
Over-expression of p53 protein in human laryngeal carcinoma.
International journal of cancer. Journal international du cancer 1993;53(6):952-6.
1993: Hironobu Naiki; K Higuchi; A Shimada; T Takeda; K Nakakuki
Genetic analysis of murine senile amyloidosis.
Laboratory investigation; a journal of technical methods and pathology 1993;68(3):332-7.
1993: K Anwar; K Nakakuki; Hironobu Naiki; Manabu Inuzuka
ras gene mutations and HPV infection are common in human laryngeal carcinoma.
International journal of cancer. Journal international du cancer 1993;53(1):22-8.
1992: K Anwar; K Nakakuki; T Shiraishi; Hironobu Naiki; R Yatani; Manabu Inuzuka
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Cancer research 1992;52(21):5991-6.
1992: K Anwar; Hironobu Naiki; K Nakakuki; Manabu Inuzuka
High frequency of human papillomavirus infection in carcinoma of the urinary bladder.
Cancer 1992;70(7):1967-73.
1991: Hironobu Naiki; K Higuchi; K Nakakuki; T Takeda
Kinetic analysis of amyloid fibril polymerization in vitro.
Laboratory investigation; a journal of technical methods and pathology 1991;65(1):104-10.