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Leonie Beljaars

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Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
Sabine Klein; Klaas Poelstra; Tilman Sauerbruch; Robert Schierwagen; Leonie Beljaars; Michaela Granzow; Iren Heidari; Sebastian Huss; Sibel Kilic; Marike Marjolijn Van Beuge; Jonel Trebicka
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.
Adriana Mattos; Leonie Beljaars; Marianne de Haan; Alie de Jager-Krikken; Klaas Poelstra
PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.

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All Publications

2013: Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
PloS one 2013;8(2):e56442.
2012: Sabine Klein; Klaas Poelstra; Tilman Sauerbruch; Robert Schierwagen; Leonie Beljaars; Michaela Granzow; Iren Heidari; Sebastian Huss; Sibel Kilic; Marike Marjolijn Van Beuge; Jonel Trebicka
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.
Journal of hepatology 2012;57(6):1220-7.
2012: Adriana Mattos; Leonie Beljaars; Marianne de Haan; Alie de Jager-Krikken; Klaas Poelstra
PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(1):84-91.
2012: Klaas Poelstra; Jai Prakash; Leonie Beljaars
Drug targeting to the diseased liver.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(2):188-97.
2011: Ruchi Bansal; Leonie Beljaars; Jai Prakash; Marieke de Ruijter; Klaas Poelstra
Peptide-modified albumin carrier explored as a novel strategy for a cell-specific delivery of interferon gamma to treat liver fibrosis.
Molecular pharmaceutics 2011;8(5):1899-909.
2011: Ruchi Bansal; Leonie Beljaars; Eduard Post; Jai Prakash; Detlef Schuppan; Klaas Poelstra
Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.
Hepatology (Baltimore, Md.) 2011;54(2):586-96.
2011: Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.
Pharmaceutical research 2011;28(8):2045-54.
2011: Heni Rachmawati; Leonie Beljaars; Catharina Reker-Smit; Hester I Bakker; Anne-miek Van Loenen-Weemaes; Marjolijn N Lub-de Hooge; Klaas Poelstra
Intravenous administration of recombinant human IL-10 suppresses the development of anti-thy 1-induced glomerulosclerosis in rats.
PDA journal of pharmaceutical science and technology / PDA 2011;65(2):116-30.
2010: Jai Prakash; Edwin de Jong; Eduard Post; Ara K Mohammad; Leonie Beljaars; Klaas Poelstra
Targeting tumor stromal cells through a PDGF-beta receptor binding carrier.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e116.
2010: Jai Prakash; Edwin de Jong; Eduard Post; Annette S H Gouw; Leonie Beljaars; Klaas Poelstra
A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier.
Journal of controlled release : official journal of the Controlled Release Society 2010;145(2):91-101.
2010: Jai Prakash; Leonie Beljaars; Akshay K Harapanahalli; Mieke Zeinstra-Smith; Alie de Jager-Krikken; Martin Hessing; Herman Steen; Klaas Poelstra
Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor.
International journal of cancer. Journal international du cancer 2010;126(8):1966-81.
2010: Montserrat Moreno; Teresa Gonzalo; Robbert J Kok; Pau Sancho-Bru; Marike van Beuge; Josine Swart; Jai Prakash; Kai Temming; Constantino Fondevila; Leonie Beljaars; Marie Lacombe; Paul van der Hoeven; Vicente Arroyo; Klaas Poelstra; David A Brenner; Pere Ginès; Ramón Bataller
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Hepatology (Baltimore, Md.) 2010;51(3):942-52.
2008: Marieke H Schoemaker; Marianne G Rots; Leonie Beljaars; Arjen Y Ypma; Peter L M Jansen; Klaas Poelstra; Han Moshage; Hidde J Haisma
PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.
Molecular pharmaceutics 2008;5(3):399-406.
2008: Werner I Hagens; Leonie Beljaars; D A Mann; Matthew C Wright; Boris Julien; Sophie Lotersztajn; Catharina Reker-Smit; Klaas Poelstra
Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.
The Journal of pharmacology and experimental therapeutics 2008;324(3):902-10.
2007: Teresa Gonzalo; Leonie Beljaars; Marja van de Bovenkamp; Kai Temming; Anne-Miek van Loenen; Catharina Reker-Smit; Dirk K F Meijer; Marie Lacombe; Frank Opdam; György Kéri; László Õrfi; Klaas Poelstra; Robbert J Kok
Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2007;321(3):856-65.
2007: Heni Rachmawati; Catharina Reker-Smit; Marjolijn N Lub-de Hooge; Anne-miek Van Loenen-Weemaes; Klaas Poelstra; Leonie Beljaars
Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):814-21.
2007: Rick Greupink; Catharina Reker-Smit; Johannes H Proost; Anne-miek Van Loenen-Weemaes; Marjolijn de Hooge; Klaas Poelstra; Leonie Beljaars
Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats.
Biochemical pharmacology 2007;73(9):1455-62.
2007: Werner I Hagens; Adriana mattos; Rick Greupink; Alie de Jager-Krikken; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; I Annette S H Gouw; Klaas Poelstra; Leonie Beljaars
Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated.
Pharmaceutical research 2007;24(3):566-74.
2007: Joost N Vermeulen; Dirk K F Meijer; Jan Over; Joep Lange; Johannes H Proost; Hester I Bakker; Leonie Beljaars; Ferdinand W N M Wit; Jan M Prins
A phase I/IIa study with succinylated human serum albumin (Suc-HSA), a candidate HIV-1 fusion inhibitor.
Antiviral therapy 2007;12(2):273-8.
2006: Rick Greupink; Hester I Bakker; Harry van Goor; Martin H de Borst; Leonie Beljaars; Klaas Poelstra
Mannose-6-phosphate/insulin-Like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells.
Pharmaceutical research 2006;23(8):1827-34.
2006: Rick Greupink; Hester I Bakker; Wilma Bouma; Catharina Reker-Smit; Dirk K F Meijer; Leonie Beljaars; Klaas Poelstra
The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo.
The Journal of pharmacology and experimental therapeutics 2006;317(2):514-21.
2006: Teresa Gonzalo; Eduard Talman; Anke van de Ven; Kai Temming; Rick Greupink; Leonie Beljaars; Catharina Reker-Smit; Dirk K F Meijer; Grietje Molema; Klaas Poelstra; Robbert J Kok
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):193-203.
2006: Werner I Hagens; Peter Olinga; Dirk K F Meijer; Geny M M Groothuis; Leonie Beljaars; Klaas Poelstra
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(2):232-9.
2006: Johannes H Proost; Leonie Beljaars; Peter Olinga; Pieter J Swart; Mirjam E Kuipers; Catharina Reker-Smit; Geny M M Groothuis; Dirk K F Meijer
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(2-3):123-32.
2005: Rick Greupink; Hester I Bakker; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Robbert J Kok; Dirk K F Meijer; Leonie Beljaars; Klaas Poelstra
Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.
Journal of hepatology 2005;43(5):884-92.
2004: Heni Rachmawati; Leonie Beljaars; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Werner I Hagens; Dirk K F Meijer; Klaas Poelstra
Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis.
Pharmaceutical research 2004;21(11):2072-8.
2004: Leonie Beljaars; Barry W A van der Strate; Hester I Bakker; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Frouwke C Wiegmans; Martin C Harmsen; Grietje Molema; Dirk K F Meijer
Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo.
Antiviral research 2004;63(3):197-208.
2003: Barry W A van der Strate; Jan-Luuk Hillebrands; S S Lycklama à Nijeholt; Leonie Beljaars; Cathrien A Bruggeman; Marja J A van Luyn; Jan Rozing; T Hauw The; Dirk K F Meijer; Grietje Molema; Martin C Harmsen
Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo.
Journal of virology 2003;77(20):11274-8.
2003: Leonie Beljaars; Betty Weert; Albert Geerts; Dirk K F Meijer; Klaas Poelstra
The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue.
Biochemical pharmacology 2003;66(7):1307-17.
2002: Ben Berkhout; Jeroen L B van Wamel; Leonie Beljaars; Dirk K F Meijer; Servaas Visser; René Floris
Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides.
Antiviral research 2002;55(2):341-55.
2002: Leonie Beljaars; René Floris; Ben Berkhout; Catharina Smit; Dirk K F Meijer; Grietje Molema
The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins.
Biochemical pharmacology 2002;63(9):1663-73.
2002: Leonie Beljaars; Dirk K F Meijer; Klaas Poelstra
Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis.
Frontiers in bioscience : a journal and virtual library 2002;7():e214-22.
2002: Mirjam E Kuipers; Leonie Beljaars; N Van Beek; H G De Vries; J Heegsma; J J M Van Den Berg; Dirk K F Meijer; Pieter J Swart
Conditions influencing the in vitro antifungal activity of lactoferrin combined with antimycotics against clinical isolates of Candida. Impact on the development of buccal preparations of lactoferrin.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(4):290-8.
2002: Leonie Beljaars; Hester I Bakker; Barry W A van der Strate; Catharina Smit; Adrian M Duijvestijn; Dirk K F Meijer; Grietje Molema
The antiviral protein human lactoferrin is distributed in the body to cytomegalovirus (CMV) infection-prone cells and tissues.
Pharmaceutical research 2002;19(1):54-62.
2001: Barry W A van der Strate; Leonie Beljaars; Grietje Molema; Martin C Harmsen; Dirk K F Meijer
Antiviral activities of lactoferrin.
Antiviral research 2001;52(3):225-39.
2001: Leonie Beljaars; Peter Olinga; Grietje Molema; Pieter De Bleser; Albert Geerts; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).
Liver 2001;21(5):320-8.
2001: Dirk K F Meijer; Leonie Beljaars; Grietje Molema; Klaas Poelstra
Disease-induced drug targeting using novel peptide-ligand albumins.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):157-64.
2001: Pieter J Swart; Mirjam E Kuipers; Catharina Smit; Leonie Beljaars; J Ter Wiel; Dirk K F Meijer
The metabolic fate of the Anti-HIV active drug carrier succinylated human serum albumin after intravenous administration in rats.
Journal of drug targeting 2001;9(2):95-109.
2000: Leonie Beljaars; Grietje Molema; Detlef Schuppan; Albert Geerts; Pieter De Bleser; Betty Weert; Dirk K F Meijer; Klaas Poelstra
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.
The Journal of biological chemistry 2000;275(17):12743-51.
1999: Pieter J Swart; T Hirano; Mirjam E Kuipers; Y Ito; Catharina Smit; M Hashida; M Nishikawa; Leonie Beljaars; Dirk K F Meijer; Klaas Poelstra
Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.
Journal of hepatology 1999;31(6):1034-43.
1999: Pieter J Swart; Leonie Beljaars; Mirjam E Kuipers; Catharina Smit; P Nieuwenhuis; Dirk K F Meijer
Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs.
Biochemical pharmacology 1999;58(9):1425-35.
1999: Leonie Beljaars; Grietje Molema; Betty Weert; H Bonnema; Peter Olinga; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;29(5):1486-93.
1998: Leonie Beljaars; Klaas Poelstra; Grietje Molema; Dirk K F Meijer
Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.
Journal of hepatology 1998;29(4):579-88.