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Vasu Nair

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TOP 3
Vasu Nair; Fan Zhang; Xiaohui Ma; Eric Bonsu
Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity.
Vasu Nair; Guochen Chi; Qingning Shu; Justin Julander; Donald F Smee
A heterocyclic molecule with significant activity against dengue virus.
Qingning Shu; Vasu Nair
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery.

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All Publications

2009: Vasu Nair; Fan Zhang; Xiaohui Ma; Eric Bonsu
Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity.
Nucleosides, nucleotides & nucleic acids 2009;28(5):408-23.
2009: Vasu Nair; Guochen Chi; Qingning Shu; Justin Julander; Donald F Smee
A heterocyclic molecule with significant activity against dengue virus.
Bioorganic & medicinal chemistry letters 2009;19(5):1425-7.
2008: Qingning Shu; Vasu Nair
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery.
Medicinal research reviews 2008;28(2):219-32.
2008: Vasu Nair; Vinod Uchil; Xiaohui Ma; Qingning Zhu; Fan Zhang; Eric Bonsu
Ribonucleosides bearing Michael acceptors: synthesis, molecular docking, enzyme inhibition data and antiviral activity.
Nucleic acids symposium series (2004) 2008;(52):625-6.
2007: Vinod Uchil; Byung Seo; Vasu Nair
A novel strategy to assemble the beta-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds.
The Journal of organic chemistry 2007;72(22):8577-9.
2007: Vasu Nair; Guochen Chi
HIV integrase inhibitors as therapeutic agents in AIDS.
Reviews in medical virology 2007;17(4):277-95.
2007: Guochen Chi; Vasu Nair; Elena Semenova; Yves Pommier
A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity.
Bioorganic & medicinal chemistry letters 2007;17(5):1266-9.
2007: Vasu Nair; Dorota G Piotrowska; Maurice Okello; Jean Vadakkan
Isonucleosides: design and synthesis of new isomeric nucleosides with antiviral potential.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):687-90.
2007: Vasu Nair; Vinod Uchil; Guochen Chi; Iwona Dams; Arthur Cox; Byung Seo
Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):665-8.
2007: Vasu Nair; Xiaohui Ma; Qingning Shu; Fan Zhang; Vinod Uchil; Govardhan R Cherukupalli
IMPDH as a biological probe for RNA antiviral drug discovery: synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):651-4.
2007: Vasu Nair; Qingning Shu
Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.
Antiviral chemistry & chemotherapy 2007;18(5):245-58.
2006: Abdumalik Nishonov; Xiaohui Ma; Vasu Nair
Azadideoxyadenosine: synthesis, enzymology, and anti-HIV activity.
Bioorganic & medicinal chemistry letters 2006;16(15):4099-101.
2006: Vasu Nair; Vinod Uchil; Nouri Neamati
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.
Bioorganic & medicinal chemistry letters 2006;16(7):1920-3.
2006: Vasu Nair; Guochen Chi; Roger Ptak; Nouri Neamati
HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.
Journal of medicinal chemistry 2006;49(2):445-7.
2006: Arthur G Cox; Vasu Nair
Novel HIV integrase inhibitors with anti-HIV activity: insights into integrase inhibition from docking studies.
Antiviral chemistry & chemotherapy 2006;17(6):343-53.
2005: M Gary Newton; Charles F Campana; Guo Chen Chi; Doowon Lee; Zhi-Jie Liu; Vasu Nair; James Phillips; John P Rose; Bi-Cheng Wang
A non-natural dinucleotide containing an isomeric L-related deoxynucleoside: dinucleotide inhibitors of anti-HIV integrase activity.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 8):o518-20.
2005: Guochen Chi; Vasu Nair
Synthetic approaches to nuclease-resistant, nonnatural dinucleotides of anti-HIV integrase interest.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1449-68.
2005: Joel Melroy; Vasu Nair
The antiviral activity, mechanism of action, clinical significance and resistance of abacavir in the treatment of pediatric AIDS.
Current pharmaceutical design 2005;11(29):3847-52.
2005: AJR Chun; Jean John Vadakkan; Vasu Nair
Ring-expanded analogues of natural oxetanocin: (+) and (-) hydroxymethyl isodideoxyadenosine.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):725-8.
2005: Sherry Story; Mukta Gupta; Eric Bonsu; Vasu Nair
Inhibitors of inosine monophosphate dehydrogenase: probes for antiviral drug discovery.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):717-20.
2005: Guochen Chi; Byung I Seo; Vasu Nair
Design and synthesis of specific inhibitors of the 3'-processing step of HIV-1 integrase.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):481-4.
2005: Vasu Nair; Sanjib Bera
Acyclic nucleosides bearing a furanyl scaffold.
Nucleosides, nucleotides & nucleic acids 2005;24(1):37-43.
2004: Guochen Chi; Nouri Neamati; Vasu Nair
Inhibition of the strand transfer step of HIV-1 integrase by non-natural dinucleotides.
Bioorganic & medicinal chemistry letters 2004;14(19):4815-7.
2004: Vasu Nair; Suresh Pal
Resistance towards exonucleases of dinucleotides with stereochemically altered internucleotide phosphate bonds.
Bioorganic & medicinal chemistry letters 2004;14(1):289-91.
2004: Sven Guenther; Vasu Nair
A new approach for the synthesis of novel 5-substituted isodeoxyuridine analogs.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):183-93.
2003: Vasu Nair; Travis Mickle; Sanjib Bera
Cyclopropyl and related analogs of the anti-HIV compound, isodideoxyadenosine.
Nucleosides, nucleotides & nucleic acids 2003;22(3):239-47.
2003: Vasu Nair; Ramesh C Kamboj
Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate.
Bioorganic & medicinal chemistry letters 2003;13(4):645-7.
2003: Vasu Nair; Bindu Bera; Earl R Kern
Synthesis and biological activities of 2-functionalized purine nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(2):115-27.
2003: Vasu Nair
Novel inhibitors of HIV integrase: the discovery of potential anti-HIV therapeutic agents.
Current pharmaceutical design 2003;9(31):2553-65.
2002: Sven Guenther; Jan Balzarini; Erik De Clercq; Vasu Nair
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
Journal of medicinal chemistry 2002;45(25):5426-9.
2002: Suresh Pal; Bindu Bera; Vasu Nair
Inhibition of inosine monophosphate dehydrogenase (IMPDH) by the antiviral compound, 2-vinylinosine monophosphate.
Bioorganic & medicinal chemistry 2002;10(11):3615-8.
2002: Sven Guenther; Vasu Nair
Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.
Bioorganic & medicinal chemistry letters 2002;12(16):2233-6.
2002: Vasu Nair
HIV integrase as a target for antiviral chemotherapy.
Reviews in medical virology 2002;12(3):179-93.
2001: M Taktakishvili; N Neamati; Y Pommier; Vasu Nair
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.
Bioorganic & medicinal chemistry letters 2001;11(11):1433-5.
2001: Vasu Nair; M Taktakishvili
A new procedure for the phosphorylation of nucleosides: application to the discovery of inhibitors of HIV integrase.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):739-42.
2001: Vasu Nair; D S Sosnouski; Q Zhu
Isonucleosides incorporating universal bases.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):735-8.
2000: S Pal; Vasu Nair
Phosphorylation of the anti-HIV compound (S,S)-isodideoxyadenosine by human recombinant deoxycytidine kinase.
Biochemical pharmacology 2000;60(10):1505-8.
2000: Travis Mickle; Vasu Nair
Anti-human immunodeficiency virus activities of nucleosides and nucleotides: correlation with molecular electrostatic potential data.
Antimicrobial agents and chemotherapy 2000;44(11):2939-47.
2000: P K Sharma; Vasu Nair
Synthesis of 3'-trifluoromethyl nucleosides as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids 2000;19(4):757-74.
2000: M Taktakishvili; N Neamati; Y Pommier; Vasu Nair
Recognition and inhibition of HIV integrase by a novel dinucleotide.
Bioorganic & medicinal chemistry letters 2000;10(3):249-51.
2000: N Nishizono; Vasu Nair
Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):283-95.
1999: Sanjib Bera; Travis Mickle; Vasu Nair
Synthesis and antiviral studies of unsaturated analogues of isomeric dideoxynucleosides.
Nucleosides & nucleotides 1999;18(11-12):2379-95.
1999: X Zheng; Vasu Nair
Homologues of isomeric dideoxynucleosides as potential antiviral agents: synthesis of isodideoxynucleosides with a furanethanol sugar moiety.
Nucleosides & nucleotides 1999;18(9):1961-76.
1999: Travis Mickle; Vasu Nair
Correlation of anti-HIV activity with structure: use of electrostatic potential and conformational analysis.
Bioorganic & medicinal chemistry letters 1999;9(14):1963-8.
1999: S Van Calenbergh; Vasu Nair
Synthesis of a nucleoside bioconjugate system as a potential anti-HIV agent.
Nucleosides & nucleotides 1999;18(4-5):737-8.
1999: C Mathé; Vasu Nair
Potential inhibitors of HIV integrase.
Nucleosides & nucleotides 1999;18(4-5):681-2.
1999: Vasu Nair; Sanjib Bera; Travis Mickle; S Van Calenbergh
Synthesis of novel isomeric dideoxydidehydronucleosides.
Nucleosides & nucleotides 1999;18(4-5):577-9.
1998: T Wenzel; Vasu Nair
Self-complementary oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: synthesis, physical characterization, enzymology, and CD studies.
Bioconjugate chemistry 1998;9(6):683-90.
1998: J Zhang; N Neamati; Y Pommier; Vasu Nair
Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.
Bioorganic & medicinal chemistry letters 1998;8(14):1887-90.
1995: Vasu Nair; Marty St Clair; J E Reardon; H C Krasny; R J Hazen; M T Paff; L R Boone; M Tisdale; I Najera; R E Dornsife
Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol.
Antimicrobial agents and chemotherapy 1995;39(9):1993-9.
1995: Vasu Nair; T S Jahnke
Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.
Antimicrobial agents and chemotherapy 1995;39(5):1017-29.
1992: Vasu Nair; M A Ussery
New hypoxanthine nucleosides with RNA antiviral activity.
Antiviral research 1992;19(2):173-8.
1992: Vasu Nair; T B Sells
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.
Biochimica et biophysica acta 1992;1119(2):201-4.
1991: Vasu Nair; G S Buenger; T B Sells
Inhibition of mammalian adenosine deaminase by novel functionalized 2',3'-dideoxyadenosines.
Biochimica et biophysica acta 1991;1078(1):121-3.
1986: Vasu Nair; C S Cooper; D E Vietti; G A Turner
The chemistry of lipid peroxidation metabolites: crosslinking reactions of malondialdehyde.
Lipids 1986;21(1):6-10.
1977: B H Jo; Vasu Nair; L Davis
Carbon-13 nuclear magnetic resonance studies of vitamin B6 Schiff base and carbinolamine formation in aqueous solution.1 1. The adduct of pyridoxal 5'-phosphate and DL-alanine.
Journal of the American Chemical Society 1977;99(13):4467-71.