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James Naismith

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Escherichia coli

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Publications

TOP 3
Judith Reeks; Richard D Sokolowski; Shirley Graham; Huanting Liu; James H Naismith; Malcolm F White
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing.
Simon R Bushell; Hubing Lou; Iain L Mainprize; Martin A Wear; Chris Whitfield; James H Naismith
Wzi Is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia coli.
Jesko Koehnke; Falk Morawitz; Sally L Shirran; Iain A Smellie; Margaret C M Smith; Andrew F Bent; Catherine H Botting; Matthew A Fuszard; Wael E Houssen; Marcel Jaspars; James H Naismith
An enzymatic route to selenazolines.

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All Publications

2013: Judith Reeks; Richard D Sokolowski; Shirley Graham; Huanting Liu; James H Naismith; Malcolm F White
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing.
The Biochemical journal 2013;452(2):223-30.
2013: Simon R Bushell; Hubing Lou; Iain L Mainprize; Martin A Wear; Chris Whitfield; James H Naismith
Wzi Is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia coli.
Structure (London, England : 1993) 2013;21(5):844-53.
2013: Jesko Koehnke; Falk Morawitz; Sally L Shirran; Iain A Smellie; Margaret C M Smith; Andrew F Bent; Catherine H Botting; Matthew A Fuszard; Wael E Houssen; Marcel Jaspars; James H Naismith
An enzymatic route to selenazolines.
Chembiochem : a European journal of chemical biology 2013;14(5):564-7.
2013: Magnus S Alphey; Wassila Abdelli Boulkeroua; Ruth Brenk; Robert A Field; Mary Gardiner; David Gray; Marko Maringer; Michael McNeil; Wulf Oehlmann; Lisa Pirrie; Martin Rejzek; Aurijit Sarkar; Michael S Scherman; Mahavir Singh; Leah S Torrie; Nicholas J Westwood; James H Naismith
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS chemical biology 2013;8(2):387-96.
2013: Lucile Moynié; Andrew D Smith; James W Taylor; Magnus S Alphey; Ruth Brenk; Fraser G Duthie; Alessa Koehnke; Stuart M Leckie; Stephen McMahon; James H Naismith
Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa.
Journal of molecular biology 2013;425(2):365-77.
2013: Lucille Moynie; James H Naismith; Tatyana Sandalova; Jason W Schmidberger; Robert Schnell; Magnus S Alphey; Wassila Abdelli Boulkerou; Cyprian Cukier; Fraser Duthie; William N Hunter; Agata Jacewicz; Jolanta Kopec; Huanting Liu; Stephen McMahon; Gunter Schneider
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Acta crystallographica. Section F, Structural biology and crystallization communications 2013;69(Pt 1):25-34.
2012: Wael E Houssen; Jesko Koehnke; James H Naismith; Andrea Raab; Margaret C M Smith; Jeremie Vendome; David Zollman; Marcel Jaspars
The discovery of new cyanobactins from cyanothece PCC 7425 defines a new signature for processing of patellamides.
Chembiochem : a European journal of chemical biology 2012;13(18):2683-9.
2012: Gregor Hagelueken; Hexian Huang; Tomas Lebl; Bradley R Clarke; Chris Whitfield; James H Naismith
Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a.
Molecular microbiology 2012;86(3):730-42.
2012: Christos Pliotas; Akiko Rasmussen; Olav Schiemann; Richard Ward; Susan S Black; Ian R Booth; Emma Branigan; Gregor Hagelueken; Hexian Huang; James H Naismith
Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):E2675-82.
2012: Gregor Hagelueken; Karl Harlos; Hexian Huang; Bradley R Clarke; Chris Whitfield; James H Naismith
Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 10):1371-9.
2012: Anna Plechanovová; Michael H Tatham; Ellis Jaffray; James H Naismith; Ron Thomas Hay
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
Nature 2012;489(7414):115-20.
2012: Jesko Koehnke; Falk Morawitz; Andrew Bent; Catherine H Botting; Wael E Houssen; Marcel Jaspars; Ada F Nneoyiegbe; Sally Shirran; Margaret C M Smith; Laurent Trembleau; Jeremie Vendome; David Zollman; James H Naismith
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain.
Nature structural & molecular biology 2012;19(8):767-72.
2012: Xiaofeng Zhu; Xuan Yan; Lester G Carter; Peter J Coote; Shirley Graham; Huanting Liu; James H Naismith
A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 6):610-5.
2012: Jonathan Lowther; James H Naismith; Teresa M Dunn; Dominic J Campopiano
Structural, mechanistic and regulatory studies of serine palmitoyltransferase.
Biochemical Society transactions 2012;40(3):547-54.
2012: James H Naismith
Tryptophan oxygenation: mechanistic considerations.
Biochemical Society transactions 2012;40(3):509-14.
2012: Sonia Paytubi; Catherine H Botting; Shirley Graham; Eugene V Koonin; Huanting Liu; Kira S Makarova; Stephen McMahon; James H Naismith; Malcolm F White
Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):E398-405.
2012: Jing Zhang; Sonja-Verena Albers; Kim Brugger; Giuseppe Cannone; Shirley Graham; Melina Kerou; Huanting Liu; James H Naismith; Judith Reeks; Julia Reimann; Christophe Rouillon; Laura Spagnolo; Malcolm F White
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.
Molecular cell 2012;45(3):303-13.
2012: Wenjian Wang; Tim Rasmussen; Ian R Booth; Nuala A Booth; Amanda J Harding; James H Naismith
Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function.
Journal of molecular biology 2012;415(3):538-46.
2012: James H Naismith; Ian R Booth
Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.
Annual review of biophysics 2012;41():157-77.
2011: Stefan Schmelz; Lijiang Song; Catherine H Botting; Gregory L Challis; Nadia F Kadi; James H Naismith
Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD.
Journal of molecular biology 2011;412(3):495-504.
2011: Anna Plechanovová; Ellis G Jaffray; Kenneth A Johnson; Stephen A McMahon; James H Naismith; Iva Navrátilová; Ronald T Hay
Mechanism of ubiquitylation by dimeric RING ligase RNF4.
Nature structural & molecular biology 2011;18(9):1052-9.
2011: Erin M Wilfong; Amber Bowie; Yu Du; Christopher M Hadad; Yuri Kogiso; Thomas Kowatz; Sivaramakrishnan Muthukrishnan; James H Naismith; Eric J Toone; Terry L Gustafson
A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model.
Journal of the American Chemical Society 2011;133(30):11515-23.
2011: Emma L R Compton; Frank Gabel; Eleni Karinou; James H Naismith; Arnaud Javelle
Low resolution structure of a bacterial SLC26 transporter reveals dimeric stoichiometry and mobile intracellular domains.
The Journal of biological chemistry 2011;286(30):27058-67.
2011: Alexander Lang; Stefan Polnick; Tristan Nicke; Peter William; Eugenio P Patallo; James H Naismith; Karl-Heinz van Pée
Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis.
Angewandte Chemie (International ed. in English) 2011;50(13):2951-3.
2011: Jennifer A Harrison; K P Ravindranathan Kartha; Eric J L Fournier; Todd L Lowary; Carles Malet; Ulf J Nilsson; Ole Hindsgaul; Sergio Schenkman; James H Naismith; Robert A Field
Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries.
Organic & biomolecular chemistry 2011;9(5):1653-60.
2011: Hubing Lou; Alison S Low; Tivadar Mach; Victoria A Bamford; Hagan Bayley; Konstantinos Beis; Susan S Black; Ian R Booth; Simon R Bushell; Matteo Ceccarelli; Min Chen; James H Naismith
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli.
PloS one 2011;6(10):e25825.
2011: Muse Oke; Melina Kerou; Huanting Liu; Xu Peng; Roger A Garrett; David Prangishvili; James H Naismith; Malcolm F White
A dimeric Rep protein initiates replication of a linear archaeal virus genome: implications for the Rep mechanism and viral replication.
Journal of virology 2011;85(2):925-31.
2010: Simon R Bushell; Hubing Lou; Gregor D Wallat; Konstantinos Beis; Chris Whitfield; James H Naismith
Crystallization and preliminary diffraction analysis of Wzi, a member of the capsule export and assembly pathway in Escherichia coli.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 12):1621-5.
2010: Robert M Hagan; Ragnar Björnsson; Stephen McMahon; Benjamin Schomburg; Vickie Braithwaite; Michael Bühl; James H Naismith; Ulrich Schwarz-Linek
NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond.
Angewandte Chemie (International ed. in English) 2010;49(45):8421-5.
2010: Marine C C Raman; Kenneth A Johnson; David J Clarke; James H Naismith; Dominic J Campopiano
The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.
Biopolymers 2010;93(9):811-22.
2010: Jonathan Lowther; Beverley A Yard; Kenneth A Johnson; Lester G Carter; Venugopal T Bhat; Marine C C Raman; David J Clarke; Britta Ramakers; Stephen McMahon; James H Naismith; Dominic J Campopiano
Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.
Molecular bioSystems 2010;6(9):1682-93.
2010: Xiaofeng Zhu; Karl-Heinz van Pée; James H Naismith
The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily.
The Journal of biological chemistry 2010;285(27):21126-33.
2010: Thomas Kowatz; James P Morrison; Martin E Tanner; James H Naismith
The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism.
Protein science : a publication of the Protein Society 2010;19(7):1337-43.
2010: Jason W Schmidberger; Agata B James; Robert Edwards; James H Naismith; David O'Hagan
Halomethane biosynthesis: structure of a SAM-dependent halide methyltransferase from Arabidopsis thaliana.
Angewandte Chemie (International ed. in English) 2010;49(21):3646-8.
2010: Kerstin Steiner; Gregor Hagelueken; Paul Messner; Christina Schäffer; James H Naismith
Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus.
Journal of molecular biology 2010;397(2):436-47.
2009: Stefan Schmelz; James H Naismith
Adenylate-forming enzymes.
Current opinion in structural biology 2009;19(6):666-71.
2009: Hai Deng; Stephen A McMahon; Alessandra S Eustáquio; Bradley S Moore; James H Naismith; David O'Hagan
Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).
Chembiochem : a European journal of chemical biology 2009;10(15):2455-9.
2009: Gregor Hagelueken; Hexian Huang; Iain L Mainprize; Chris Whitfield; James H Naismith
Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly.
Journal of molecular biology 2009;392(3):678-88.
2009: Xiaofeng Zhu; Walter De Laurentis; Khim Leang; Julia Herrmann; Katja Ihlefeld; Karl-Heinz van Pée; James H Naismith
Structural insights into regioselectivity in the enzymatic chlorination of tryptophan.
Journal of molecular biology 2009;391(1):74-85.
2009: Hexian Huang; Gregor Hagelueken; Chris Whitfield; James H Naismith
Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):770-2.
2009: Stephen McMahon; Gareth A Roberts; Kenneth A Johnson; Laurie P Cooper; Huanting Liu; John H White; Lester G Carter; Bansi Sanghvi; Muse Oke; Malcolm D Walkinshaw; Garry W Blakely; James H Naismith; David T F Dryden
Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance.
Nucleic acids research 2009;37(15):4887-97.
2009: Anne-Marie McRobbie; Lester G Carter; Melina Kerou; Huanting Liu; Stephen McMahon; Kenneth Alan Johnson; Muse Oke; James H Naismith; Malcolm White
Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.
Journal of molecular biology 2009;389(4):661-73.
2009: Marine C C Raman; Kenneth Alan Johnson; Beverley A Yard; Jonathan Lowther; Lester G Carter; James H Naismith; Dominic J Campopiano
The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics.
The Journal of biological chemistry 2009;284(25):17328-39.
2009: Robert C Ford; Anne L Brunkan-LaMontagne; Richard F Collins; Bradley R Clarke; Robert Harris; James H Naismith; Chris Whitfield
Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis.
Journal of structural biology 2009;166(2):172-82.
2009: Martin Rejzek; Velupillai Sri Kannathasan; corin wing; Andrew Preston; Erin L Westman; Joseph S Lam; James H Naismith; Duncan J Maskell; Robert A Field
Chemical synthesis of UDP-Glc-2,3-diNAcA, a key intermediate in cell surface polysaccharide biosynthesis in the human respiratory pathogens B. pertussis and P. aeruginosa.
Organic & biomolecular chemistry 2009;7(6):1203-10.
2009: James Errey; Maretta C Mann; Shirley A Fairhurst; Lionel Hill; Mike R McNeil; James H Naismith; Jonathan M Percy; Chris Whitfield; Robert A Field
Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.
Organic & biomolecular chemistry 2009;7(5):1009-16.
2009: Leslie Cuthbertson; Iain L Mainprize; James H Naismith; Chris Whitfield
Pivotal roles of the outer membrane polysaccharide export and polysaccharide copolymerase protein families in export of extracellular polysaccharides in gram-negative bacteria.
Microbiology and molecular biology reviews : MMBR 2009;73(1):155-77.
2009: Stefan Schmelz; Nadia Kadi; Stephen McMahon; Lijiang Song; Daniel Oves-Costales; Muse Oke; Huanting Liu; Kenneth Alan Johnson; Lester G Carter; Catherine H Botting; Malcolm White; Gregory L Challis; James H Naismith
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.
Nature chemical biology 2009;5(3):174-82.
2009: Huanting Liu; James H Naismith
A simple and efficient expression and purification system using two newly constructed vectors.
Protein expression and purification 2009;63(2):102-11.
2009: Gregor Hagelueken; W John Ingledew; Hexian Huang; Biljana Petrovic-Stojanovska; Chris Whitfield; Hassane ElMkami; Olav Schiemann; James H Naismith
PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli.
Angewandte Chemie (International ed. in English) 2009;48(16):2904-6.
2008: Kerstin Steiner; Anna Wojciechowska; Christina Schäffer; James H Naismith
Purification, crystallization and preliminary crystallographic analysis of WsaF, an essential rhamnosyltransferase from Geobacillus stearothermophilus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 12):1163-5.
2008: Stephen McMahon; Muse Oke; Huanting Liu; Kenneth Alan Johnson; Lester Carter; Nadia Kadi; Malcolm White; Gregory L Challis; James H Naismith
Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 11):1052-5.
2008: Wenjian Wang; Susan S Black; Michelle D Edwards; Samantha Miller; Emma L Morrison; Wendy Bartlett; Changjiang Dong; James H Naismith; Ian R Booth
The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.
Science (New York, N.Y.) 2008;321(5893):1179-83.
2008: Wenjian Wang; Changjiang Dong; Michael McNeil; Devinder Kaur; Sebabrata Mahapatra; Dean Crick; James H Naismith
The structural basis of chain length control in Rv1086.
Journal of molecular biology 2008;381(1):129-40.
2008: Chris Whitfield; James H Naismith
Periplasmic export machines for outer membrane assembly.
Current opinion in structural biology 2008;18(4):466-74.
2008: Ian M Overton; C A Johannes van Niekerk; Lester G Carter; Alice Dawson; David M A Martin; Scott Cameron; Stephen McMahon; Malcolm White; William N Hunter; James H Naismith; Geoffrey J Barton
TarO: a target optimisation system for structural biology.
Nucleic acids research 2008;36(Web Server issue):W190-6.
2008: Huanting Liu; Jana Rudolf; Kenneth Alan Johnson; Stephen McMahon; Muse Oke; Lester Carter; Anne-Marie McRobbie; Sara E Brown; James H Naismith; Malcolm White
Structure of the DNA repair helicase XPD.
Cell 2008;133(5):801-12.
2008: Michael Fairhead; Kenneth Alan Johnson; Thomas Kowatz; Stephen McMahon; Lester G Carter; Muse Oke; Huanting Liu; James H Naismith; Christopher F van der Walle
Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras.
Chemical communications (Cambridge, England) 2008;(15):1765-7.
2008: Jodi D Richards; Kenneth Alan Johnson; Huanting Liu; Anne-Marie McRobbie; Stephen McMahon; Muse Oke; Lester Carter; James H Naismith; Malcolm White
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains.
The Journal of biological chemistry 2008;283(8):5118-26.
2008: Matthew J Walters; Velupillai Srikannathasan; Andrew R McEwan; James H Naismith; Carol A Fierke; Eric J Toone
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
Bioorganic & medicinal chemistry 2008;16(2):710-20.
2008: Huanting Liu; James H Naismith
An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol.
BMC biotechnology 2008;8():91.
2008: Silvana Flecks; Eugenio P Patallo; Xiaofeng Zhu; Aliz J Ernyei; Gotthard Seifert; Alexander Schneider; Changjiang Dong; James H Naismith; Karl-Heinz van Pée
New insights into the mechanism of enzymatic chlorination of tryptophan.
Angewandte Chemie (International ed. in English) 2008;47(49):9533-6.
2008: Muse Oke; Rosalind Tan Yan Ching; Lester G Carter; Kenneth Alan Johnson; Huanting Liu; Stephen McMahon; Malcolm White; Carlos Bloch; Catherine H Botting; Martin A Walsh; Aishah A Latiff; Malcolm W Kennedy; Alan Cooper; James H Naismith
Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog.
Angewandte Chemie (International ed. in English) 2008;47(41):7853-6.
2007: Xiaofeng Zhu; David A Robinson; Andrew R McEwan; David O'Hagan; James H Naismith
Mechanism of enzymatic fluorination in Streptomyces cattleya.
Journal of the American Chemical Society 2007;129(47):14597-604.
2007: Beverley A Yard; Lester G Carter; Kenneth Alan Johnson; Ian M Overton; Mark Dorward; Huanting Liu; Stephen McMahon; Muse Oke; Daphné Puech; Geoffrey J Barton; James H Naismith; Dominic J Campopiano
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.
Journal of molecular biology 2007;370(5):870-86.
2007: Jaldappagari Seetharamappa; Muse Oke; Huanting Liu; Stephen McMahon; Kenneth Alan Johnson; Lester Carter; Mark Dorward; Michal Zawadzki; Ian M Overton; C A Johannes van Niekirk; Shirley Graham; Catherine H Botting; Garry L Taylor; Malcolm White; Geoffrey J Barton; Peter J Coote; James H Naismith
Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 6):488-91.
2007: Jaldappagari Seetharamappa; Muse Oke; Huanting Liu; Stephen McMahon; Kenneth Alan Johnson; Lester Carter; Mark Dorward; Michal Zawadzki; Ian M Overton; C A Johannes van Niekirk; Shirley Graham; Catherine H Botting; Garry L Taylor; Malcolm White; Geoffrey J Barton; Peter J Coote; James H Naismith
Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 5):452-6.
2007: Richard F Collins; Konstantinos Beis; Changjiang Dong; Catherine H Botting; Catherine McDonnell; Robert C Ford; Bradley R Clarke; Chris Whitfield; James H Naismith
The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2390-5.
2007: Changjiang Dong; Louise L Major; Velupillai Srikannathasan; James Errey; Marie-France Giraud; Joseph S Lam; Michael Graninger; Paul Messner; Mike R McNeil; Robert A Field; Chris Whitfield; James H Naismith
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
Journal of molecular biology 2007;365(1):146-59.
2006: Linnan Shen; Michael H Tatham; Changjiang Dong; Anna Zagórska; James H Naismith; Ron Thomas Hay
SUMO protease SENP1 induces isomerization of the scissile peptide bond.
Nature structural & molecular biology 2006;13(12):1069-77.
2006: Changjiang Dong; Konstantinos Beis; Jutta Nesper; Anne L Brunkan-Lamontagne; Bradley R Clarke; Chris Whitfield; James H Naismith
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.
Nature 2006;444(7116):226-9.
2006: Walter De Laurentis; Khim Leang; Katrin Hahn; Bianca Podemski; Ariane Adam; Sonja Kroschwald; Lester G Carter; Karl-Heinz van Pee; James H Naismith
Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 11):1134-7.
2006: Stephen McMahon; Martin A Walsh; Rosalind Tan Yan Ching; Lester G Carter; Mark Dorward; Kenneth Alan Johnson; Huanting Liu; Muse Oke; Carlos Bloch; Malcolm W Kennedy; Aishah A Latiff; Alan Cooper; Garry L Taylor; Malcolm White; James H Naismith
Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 11):1124-6.
2006: Gareth Williams; Kenneth Johnson; Jana Rudolf; Stephen McMahon; Lester Carter; Muse Oke; Huanting Liu; Garry L Taylor; Malcolm White; James H Naismith
Structure of the heterotrimeric PCNA from Sulfolobus solfataricus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):944-8.
2006: James H Naismith
Inferring the chemical mechanism from structures of enzymes.
Chemical Society reviews 2006;35(9):763-70.
2006: Konstantinos Beis; Chris Whitfield; Ian Booth; James H Naismith
Two-step purification of outer membrane proteins.
International journal of biological macromolecules 2006;39(1-3):10-4.
2006: Lin-nan Shen; Changjiang Dong; Huanting Liu; James H Naismith; Ron Thomas Hay
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.
The Biochemical journal 2006;397(2):279-88.
2006: Stephen W B Fullerton; Jennifer S Griffiths; Alexandra B Merkel; Manoj Cheriyan; Nathan J Wymer; Michael J Hutchins; Carol A Fierke; Eric J Toone; James H Naismith
Mechanism of the Class I KDPG aldolase.
Bioorganic & medicinal chemistry 2006;14(9):3002-10.
2006: Steven L Cobb; Hai Deng; Andrew R McEwan; James H Naismith; David O'Hagan; David A Robinson
Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Organic & biomolecular chemistry 2006;4(8):1458-60.
2006: Andrew R McEwan; Huanting Liu; Muse Oke; Lester Carter; Helen Powers; Mark Dorward; Stephen McMahon; Malcolm White; James H Naismith
Overexpression, purification, crystallization and data collection of Sulfolobus solfataricus Sso6206, a novel highly conserved protein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):228-30.
2006: Richard F Collins; Konstantinos Beis; Bradley R Clarke; Robert C Ford; Martyn Hulley; James H Naismith; Chris Whitfield
Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules.
The Journal of biological chemistry 2006;281(4):2144-50.
2006: Hai Deng; Steven L Cobb; Andrew R McEwan; Ryan P McGlinchey; James H Naismith; David O'Hagan; David A Robinson; Jonathan B Spencer
The fluorinase from Streptomyces cattleya is also a chlorinase.
Angewandte Chemie (International ed. in English) 2006;45(5):759-62.
2006: Karl-Heinz van Pée; Changjiang Dong; Silvana Flecks; James H Naismith; Eugenio P Patallo; Tobias Wage
Biological halogenation has moved far beyond haloperoxidases.
Advances in applied microbiology 2006;59():127-57.
2005: Louise L Major; Beata A Wolucka; James H Naismith
Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site.
Journal of the American Chemical Society 2005;127(51):18309-20.
2005: Changjiang Dong; Silvana Flecks; Susanne Unversucht; Caroline Haupt; Karl-Heinz van Pée; James H Naismith
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.
Science (New York, N.Y.) 2005;309(5744):2216-9.
2005: Gareth Williams; Steven D Breazeale; Christian R H Raetz; James H Naismith
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
The Journal of biological chemistry 2005;280(24):23000-8.
2005: Konstantinos Beis; Velupillai Srikannathasan; Huanting Liu; Stephen W B Fullerton; Vicki A Bamford; David A R Sanders; Chris Whitfield; Mike R McNeil; James H Naismith
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.
Journal of molecular biology 2005;348(4):971-82.
2005: Lin-nan Shen; Huanting Liu; Changjiang Dong; Dimitris P Xirodimas; James H Naismith; Ron Thomas Hay
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.
The EMBO journal 2005;24(7):1341-51.
2004: James H Naismith
Chemical insights from structural studies of enzymes.
Biochemical Society transactions 2004;32(Pt 5):647-54.
2004: Changjiang Dong; Alexander Kotzsch; Mark Dorward; Karl-Heinz van Pée; James H Naismith
Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1438-40.
2004: Alexandra B Merkel; Louise L Major; James Errey; Michael D Burkart; Robert A Field; Christopher T Walsh; James H Naismith
The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.
The Journal of biological chemistry 2004;279(31):32684-91.
2004: Konstantinos Beis; Richard F Collins; Robert C Ford; Alhaji Bukar Kamis; Chris Whitfield; James H Naismith
Three-dimensional structure of Wza, the protein required for translocation of group 1 capsular polysaccharide across the outer membrane of Escherichia coli.
The Journal of biological chemistry 2004;279(27):28227-32.
2004: Konstantinos Beis; Jutta Nesper; Chris Whitfield; James H Naismith
Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 3):558-60.
2004: Changjiang Dong; Fanglu Huang; Hai Deng; Christoph Schaffrath; Jonathan B Spencer; David O'Hagan; James H Naismith
Crystal structure and mechanism of a bacterial fluorinating enzyme.
Nature 2004;427(6974):561-5.
2003: Jutta Nesper; Chris M D Hill; Anne Paiment; George Harauz; Konstantinos Beis; James H Naismith; Chris Whitfield
Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza.
The Journal of biological chemistry 2003;278(50):49763-72.
2003: Changjiang Dong; Hai Deng; Mark Dorward; Christoph Schaffrath; David O'Hagan; James H Naismith
Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2292-3.
2003: Konstantinos Beis; Simon T M Allard; Adrian D Hegeman; Garib Murshudov; Douglas Philp; James H Naismith
The structure of NADH in the enzyme dTDP-d-glucose dehydratase (RmlB).
Journal of the American Chemical Society 2003;125(39):11872-8.
2003: Andrea Rahn; Konstantinos Beis; James H Naismith; Chris Whitfield
A novel outer membrane protein, Wzi, is involved in surface assembly of the Escherichia coli K30 group 1 capsule.
Journal of bacteriology 2003;185(19):5882-90.
2003: Rona R Ramsay; James H Naismith
A snapshot of carnitine acetyltransferase.
Trends in biochemical sciences 2003;28(7):343-6.
2003: Iain D Kerr; Ross I M Wadsworth; Liza Cubeddu; Wulf Blankenfeldt; James H Naismith; Malcolm White
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein.
The EMBO journal 2003;22(11):2561-70.
2003: Changjiang Dong; Louise L Major; Andrew Allen; Wulf Blankenfeldt; Duncan J Maskell; James H Naismith
High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme.
Structure (London, England : 1993) 2003;11(6):715-23.
2003: Changjiang Dong; Konstantinos Beis; Marie-France Giraud; Wulf Blankenfeldt; Simon T M Allard; Louise L Major; Iain D Kerr; Chris Whitfield; James H Naismith
A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose.
Biochemical Society transactions 2003;31(Pt 3):532-6.
2003: Stephen W B Fullerton; Simon Daff; David A R Sanders; W John Ingledew; Chris Whitfield; Stephen K Chapman; James H Naismith
Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate.
Biochemistry 2003;42(7):2104-9.
2002: Alexandra B Merkel; Genevieve K Temple; Michael D Burkart; Heather C Losey; Konstantinos Beis; Christopher T Walsh; James H Naismith
Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 7):1226-8.
2002: Wulf Blankenfeldt; Iain D Kerr; Marie-France Giraud; Helen J McMiken; Gordon Leonard; Chris Whitfield; Paul Messner; Michael Graninger; James H Naismith
Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode.
Structure (London, England : 1993) 2002;10(6):773-86.
2002: Miryam Asuncion; Wulf Blankenfeldt; John N Barlow; David Gani; James H Naismith
The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step.
The Journal of biological chemistry 2002;277(10):8306-11.
2002: Simon T M Allard; Konstantinos Beis; Marie-France Giraud; Adrian D Hegeman; Jeffrey W Gross; Rupert C Wilmouth; Chris Whitfield; Michael Graninger; Paul Messner; Andrew G Allen; Duncan J Maskell; James H Naismith
Toward a structural understanding of the dehydratase mechanism.
Structure (London, England : 1993) 2002;10(1):81-92.
2001: Simon T M Allard; Marie-France Giraud; James H Naismith
Epimerases: structure, function and mechanism.
Cellular and molecular life sciences : CMLS 2001;58(11):1650-65.
2001: David A R Sanders; AG Staines; Stephen McMahon; Mike R McNeil; Chris Whitfield; James H Naismith
UDP-galactopyranose mutase has a novel structure and mechanism.
Nature structural biology 2001;8(10):858-63.
2001: David A R Sanders; Stephen McMahon; G L Leonard; James H Naismith
Molecular placement of experimental electron density: a case study on UDP-galactopyranose mutase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 10):1415-20.
2001: Michael H Tatham; Ellis Jaffray; Owen A Vaughan; Joana M P Desterro; Catherine H Botting; James H Naismith; Ron Thomas Hay
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
The Journal of biological chemistry 2001;276(38):35368-74.
2001: Iain D Kerr; R I Wadsworth; Wulf Blankenfeldt; AG Staines; Malcolm White; James H Naismith
Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1290-2.
2001: David A R Sanders; DN Moothoo; J Raftery; A J Howard; J R Helliwell; James H Naismith
The 1.2 A resolution structure of the Con A-dimannose complex.
Journal of molecular biology 2001;310(4):875-84.
2001: Miryam Asuncion; J N Barlow; J Pollard; AG Staines; Stephen McMahon; Wulf Blankenfeldt; David Gani; James H Naismith
Overexpression, purification, crystallization and data collection of 3-methylaspartase from Clostridium tetanomorphum.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 5):731-3.
2001: Simon T M Allard; Marie-France Giraud; Chris Whitfield; Michael Graninger; Paul Messner; James H Naismith
The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway.
Journal of molecular biology 2001;307(1):283-95.
2001: J A Harrison; K P Ravindranathan Kartha; W B Turnbull; S L Scheuerl; James H Naismith; Sergio Schenkman; Robert A Field
Hydrolase and sialyltransferase activities of trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-gal-Gal-beta-O-PNP.
Bioorganic & medicinal chemistry letters 2001;11(2):141-4.
2001: Nathan J Wymer; LV Buchanan; D Henderson; N Mehta; Catherine H Botting; Luka Pocivavsek; Carol A Fierke; Eric J Toone; James H Naismith
Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
Structure (London, England : 1993) 2001;9(1):1-9.
2000: Wulf Blankenfeldt; Miryam Asuncion; Joseph S Lam; James H Naismith
The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).
The EMBO journal 2000;19(24):6652-63.
2000: Wulf Blankenfeldt; Marie-France Giraud; G Leonard; R Rahim; C Creuzenet; Joseph S Lam; James H Naismith
The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1501-4.
2000: Marie-France Giraud; GA Leonard; Robert A Field; C Berlind; James H Naismith
RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase.
Nature structural biology 2000;7(5):398-402.
2000: Simon T M Allard; Marie-France Giraud; Chris Whitfield; Paul Messner; James H Naismith
The purification, crystallization and structural elucidation of dTDP-D-glucose 4,6-dehydratase (RmlB), the second enzyme of the dTDP-L-rhamnose synthesis pathway from Salmonella enterica serovar typhimurium.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 2):222-5.
1999: Marie-France Giraud; H J McMiken; GA Leonard; Paul Messner; Chris Whitfield; James H Naismith
Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 12):2043-6.
1999: LV Buchanan; N Mehta; Luka Pocivavsek; Somashekarappa Niranjanakumari; Eric J Toone; James H Naismith
Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 11):1946-8.
1999: DN Moothoo; B Canan; Robert A Field; James H Naismith
Man alpha1-2 Man alpha-OMe-concanavalin A complex reveals a balance of forces involved in carbohydrate recognition.
Glycobiology 1999;9(6):539-45.
1999: Marie-France Giraud; F M Gordon; Chris Whitfield; Paul Messner; Stephen McMahon; James H Naismith
Purification, crystallization and preliminary structural studies of dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC), the third enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):706-8.
1999: Stephen McMahon; GA Leonard; LV Buchanan; Marie-France Giraud; James H Naismith
Initiating a crystallographic study of UDP-galactopyranose mutase from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):399-402.
1999: DN Moothoo; James H Naismith
A general method for co-crystallization of concanavalin A with carbohydrates.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):353-5.
1998: DN Moothoo; Stephen McMahon; S M Dimick; Eric J Toone; James H Naismith
Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):1023-5.
1998: M F Giraud; Joana M P Desterro; James H Naismith
Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):891-8.
1998: James H Naismith; S R Sprang
Modularity in the TNF-receptor family.
Trends in biochemical sciences 1998;23(2):74-9.
1998: DN Moothoo; James H Naismith
Concanavalin A distorts the beta-GlcNAc-(1-->2)-Man linkage of beta-GlcNAc-(1-->2)-alpha-Man-(1-->3)-[beta-GlcNAc-(1-->2)-alpha-Man- (1-->6)]-Man upon binding.
Glycobiology 1998;8(2):173-81.
1997: J A Harrison; K P Ravindranathan Kartha; S L Smith; James H Naismith; Sergio Schenkman; Robert A Field
Development of a high through-put spectrophotometric assay to monitor Trypanosoma cruzi trans-sialidase.
Biochemical Society transactions 1997;25(3):424S.
1996: S J Cooper; G A Leonard; S M McSweeney; A W Thompson; James H Naismith; S Qamar; A Plater; A Berry; William N Hunter
The crystal structure of a class II fructose-1,6-bisphosphate aldolase shows a novel binuclear metal-binding active site embedded in a familiar fold.
Structure (London, England : 1993) 1996;4(11):1303-15.
1996: James H Naismith; T Q Devine; T Kohno; Stephen R Sprang
Structures of the extracellular domain of the type I tumor necrosis factor receptor.
Structure (London, England : 1993) 1996;4(11):1251-62.
1996: James H Naismith; B J Brandhuber; T Q Devine; Stephen R Sprang
Seeing double: crystal structures of the type I TNF receptor.
Journal of molecular recognition : JMR 1996;9(2):113-7.
1996: James H Naismith; Robert A Field
Structural basis of trimannoside recognition by concanavalin A.
The Journal of biological chemistry 1996;271(2):972-6.
1995: James H Naismith; T Q Devine; B J Brandhuber; Stephen R Sprang
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
The Journal of biological chemistry 1995;270(22):13303-7.
1995: James H Naismith; Stephen R Sprang
Tumor necrosis factor receptor superfamily.
Journal of inflammation 1995;47(1-2):1-7.
1994: James H Naismith; C Emmerich; J Habash; S J Harrop; John R Helliwell; William N Hunter; James Raftery; A J Kalb; J Yariv
Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 6):847-58.
1994: C Emmerich; John R Helliwell; M Redshaw; James H Naismith; S J Harrop; James Raftery; A J Kalb; J Yariv; Z Dauter; K S Wilson
High-resolution structures of single-metal-substituted concanavalin A: the Co,Ca-protein at 1.6 A and the Ni,Ca-protein at 2.0 A.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 5):749-56.
1994: L E Rodseth; B Brandhuber; T Q Devine; Michael J Eck; K Hale; James H Naismith; Stephen R Sprang
Two crystal forms of the extracellular domain of type I tumor necrosis factor receptor.
Journal of molecular biology 1994;239(2):332-5.
1993: James H Naismith; J Habash; S Harrop; John R Helliwell; William N Hunter; T C Wan; S Weisgerber; A J Kalb; J Yariv
Refined structure of cadmium-substituted concanavalin A at 2.0 A resolution.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 6):561-71.
1993: Y Zhang; S Bailey; James H Naismith; Charles Bond; J Habash; P McLaughlin; M Z Papiz; A Borges; M Cunningham; Alan H Fairlamb
Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.
Journal of molecular biology 1993;232(4):1217-20.
1992: James H Naismith; J D Ferrara; S Bailey; K Marshall; Z Dauter; K S Wilson; J Habash; S J Harrop; A J Berry; William N Hunter
Initiating a crystallographic study of a class II fructose-1,6-bisphosphate aldolase.
Journal of molecular biology 1992;225(4):1137-41.