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Masao Naka

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Chemicals & Drugs

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Mami Takahashi; Tsukasa Kitahashi; Rikako Ishigamori; Michihiro Mutoh; Masami Komiya; Hidetaka Sato; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Takashi Sugimura; Keiji Wakabayashi
Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.
Hiroyuki Kohno; Mami Takahashi; Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Keiji Wakabayashi; Takuji Tanaka
A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.
Mami Takahashi; Michihiro Mutoh; Yutaka Shoji; Hidetaka Sato; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Takashi Sugimura; Keiji Wakabayashi
Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis.

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All Publications

2008: Mami Takahashi; Tsukasa Kitahashi; Rikako Ishigamori; Michihiro Mutoh; Masami Komiya; Hidetaka Sato; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Takashi Sugimura; Keiji Wakabayashi
Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.
Carcinogenesis 2008;29(8):1608-13.
2007: Hiroyuki Kohno; Mami Takahashi; Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Keiji Wakabayashi; Takuji Tanaka
A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.
International journal of cancer. Journal international du cancer 2007;121(3):506-13.
2006: Mami Takahashi; Michihiro Mutoh; Yutaka Shoji; Hidetaka Sato; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Takashi Sugimura; Keiji Wakabayashi
Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;14(2):130-6.
2003: Mami Takahashi; Michihiro Mutoh; Yutaka Shoji; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Takashi Sugimura; Keiji Wakabayashi
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Oncogene 2003;22(48):7667-76.
2003: Yasufumi Kawanaka; Kaoru Kobayashi; Shinya Kusuda; Tadashi Tatsumi; Masayuki Murota; Toshihiko Nishiyama; Katsuya Hisaichi; Atsuko Fujii; Keisuke Hirai; Masao Naka; Masaharu Komeno; Yoshihiko Odagaki; Hisao Nakai; Masaaki Toda
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Identification of 2-azabicyclo[4.1.0]heptan-3-imines.
Bioorganic & medicinal chemistry 2003;11(8):1723-43.
2003: Yasufumi Kawanaka; Kaoru Kobayashi; Shinya Kusuda; Tadashi Tatsumi; Masayuki Murota; Toshihiko Nishiyama; Katsuya Hisaichi; Atsuko Fujii; Keisuke Hirai; Minoru Nishizaki; Masao Naka; Masaharu Komeno; Hisao Nakai; Masaaki Toda
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.
Bioorganic & medicinal chemistry 2003;11(5):689-702.
2003: Yasufumi Kawanaka; Kaoru Kobayashi; Shinya Kusuda; Tadashi Tatsumi; Masayuki Murota; Toshihiko Nishiyama; Katsuya Hisaichi; Atsuko Fujii; Keisuke Hirai; Masao Naka; Masaharu Komeno; Hisao Nakai; Masaaki Toda
Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability.
European journal of medicinal chemistry 2003;38(3):277-88.
2002: Yasufumi Kawanaka; Kaoru Kobayashi; Shinya Kusuda; Tadashi Tatsumi; Masayuki Murota; Toshihiko Nishiyama; Katsuya Hisaichi; Atsuko Fujii; Keisuke Hirai; Masao Naka; Masaharu Komeno; Hisao Nakai; Masaaki Toda
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Bioorganic & medicinal chemistry letters 2002;12(17):2291-4.
2000: Masao Naka; T Nanbu; Kaoru Kobayashi; Yoshihisa Kamanaka; Masaharu Komeno; R Yanase; T Fukutomi; S Fujimura; H G Seo; N Fujiwara; Shuichi Ohuchida; K Suzuki; K Kondo; N Taniguchi
A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative.
Biochemical and biophysical research communications 2000;270(2):663-7.