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Tomohiro Nakagaki

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Disorders

Thrombotic Thrombocytopenic Purpura

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Yasushi Nakatomi; Manami Tsuji; Soutaro Gokudan; Takayoshi Hamamoto; Takako Hanada-Dateki; Hiroki Miyazaki; Tomohiro Nakagaki; Teruhisa Nakashima; Kazuhiko Tomokiyo
Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin.
Hiroshi Nishiura; Sumio Tanase; Kenichi Tsujita; Seigo Sugiyama; Hisao Ogawa; Tomohiro Nakagaki; Umeko Semba; Tetsuro Yamamoto
Maintenance of ribosomal protein S19 in plasma by complex formation with prothrombin.
Shunichiro Fuchigami; Koichi Kaikita; Kenji Soejima; Masakazu Matsukawa; Tsuyoshi Honda; Kenichi Tsujita; Yasuhiro Nagayoshi; Sunao Kojima; Tomohiro Nakagaki; Seigo Sugiyama; Hisao Ogawa
Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina.

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All Publications

2012: Yasushi Nakatomi; Manami Tsuji; Soutaro Gokudan; Takayoshi Hamamoto; Takako Hanada-Dateki; Hiroki Miyazaki; Tomohiro Nakagaki; Teruhisa Nakashima; Kazuhiko Tomokiyo
Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin.
Journal of biochemistry 2012;152(5):463-70.
2011: Hiroshi Nishiura; Sumio Tanase; Kenichi Tsujita; Seigo Sugiyama; Hisao Ogawa; Tomohiro Nakagaki; Umeko Semba; Tetsuro Yamamoto
Maintenance of ribosomal protein S19 in plasma by complex formation with prothrombin.
European journal of haematology 2011;86(5):436-41.
2008: Shunichiro Fuchigami; Koichi Kaikita; Kenji Soejima; Masakazu Matsukawa; Tsuyoshi Honda; Kenichi Tsujita; Yasuhiro Nagayoshi; Sunao Kojima; Tomohiro Nakagaki; Seigo Sugiyama; Hisao Ogawa
Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina.
Thrombosis research 2008;122(5):618-23.
2007: Hiromichi Ishizashi; Hideo Yagi; Masanori Matsumoto; Kenji Soejima; Tomohiro Nakagaki; Yoshihiro Fujimura
Quantitative Western blot analysis of plasma ADAMTS13 antigen in patients with Upshaw-Schulman syndrome.
Thrombosis research 2007;120(3):381-6.
2006: Kenji Soejima; Hitomi Nakamura; Masaki Hirashima; Wataru Morikawa; Chikateru Nozaki; Tomohiro Nakagaki
Analysis on the molecular species and concentration of circulating ADAMTS13 in Blood.
Journal of biochemistry 2006;139(1):147-54.
2005: Kazuhiko Tomokiyo; Yuichi Kamikubo; Takako Hanada; Tatsuya Araki; Yasushi Nakatomi; Yoichi Ogata; Stephanie M Jung; Tomohiro Nakagaki; Masaaki Moroi
Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions.
Blood 2005;105(3):1078-84.
2005: Kenji Soejima; Tomohiro Nakagaki
Interplay between ADAMTS13 and von Willebrand factor in inherited and acquired thrombotic microangiopathies.
Seminars in hematology 2005;42(1):56-62.
2004: Hiroshi Yonemura; Takayuki Imamura; Kenji Soejima; Yo Nakahara; Wataru Morikawa; Yoshitaka Ushio; Yasuharu Kamachi; Hiroshi Nakatake; Keishin Sugawara; Tomohiro Nakagaki; Chikateru Nozaki
Preparation of recombinant alpha-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin.
Journal of biochemistry 2004;135(5):577-82.
2004: Masanori Matsumoto; Koichi Kokame; Kenji Soejima; Masayoshi Miura; Syuhei Hayashi; Yasuhiko Fujii; Asayuki Iwai; Etsuro Ito; Yoichiro Tsuji; Mayuko Takeda-Shitaka; Mitsuo Iwadate; Hideaki Umeyama; Hideo Yagi; Hiromichi Ishizashi; Fumiaki Banno; Tomohiro Nakagaki; Toshiyuki Miyata; Yoshihiro Fujimura
Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome.
Blood 2004;103(4):1305-10.
2003: Kazuhiko Tomokiyo; Yasushi Nakatomi; T Araki; K Teshima; H Nakano; Tomohiro Nakagaki; S Miyamoto; A Funatsu; Sadaaki Iwanaga
A novel therapeutic approach combining human plasma-derived Factors VIIa and X for haemophiliacs with inhibitors: evidence of a higher thrombin generation rate in vitro and more sustained haemostatic activity in vivo than obtained with Factor VIIa alone.
Vox sanguinis 2003;85(4):290-9.
2003: Kenji Soejima; Masanori Matsumoto; Koichi Kokame; Hideo Yagi; Hiromichi Ishizashi; Hiroaki Maeda; Chikateru Nozaki; Toshiyuki Miyata; Yoshihiro Fujimura; Tomohiro Nakagaki
ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.
Blood 2003;102(9):3232-7.
2003: Masaaki Moroi; Jun Mizuguchi; Sachiko Kawashima; Michiko Nagamatsu; Yoshiki Miura; Tomohiro Nakagaki; Katsuaki Ito; Stephanie M Jung
A new monoclonal antibody, mAb 204-11, that influences the binding of platelet GPVI to fibrous collagen.
Thrombosis and haemostasis 2003;89(6):996-1003.
2003: Kazuhiko Tomokiyo; H Yano; M Imamura; Y Nakano; Tomohiro Nakagaki; Y Ogata; T Terano; S Miyamoto; A Funatsu
Large-scale production and properties of human plasma-derived activated Factor VII concentrate.
Vox sanguinis 2003;84(1):54-64.
2002: Kenji Soejima; Masato Yuguchi; Jun Mizuguchi; Kazuhiko Tomokiyo; Toshihiro Nakashima; Tomohiro Nakagaki; Sadaaki Iwanaga
The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor.
The Journal of biological chemistry 2002;277(50):49027-35.
2001: Kenji Soejima; N Mimura; Masaki Hirashima; Hiroaki Maeda; T Hamamoto; Tomohiro Nakagaki; Chikateru Nozaki
A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?
Journal of biochemistry 2001;130(4):475-80.
2001: Kenji Soejima; Jun Mizuguchi; M Yuguchi; Tomohiro Nakagaki; S Higashi; Sadaaki Iwanaga
Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property.
The Journal of biological chemistry 2001;276(20):17229-35.
2001: Kazuhiko Tomokiyo; K Teshima; Yasushi Nakatomi; T Watanabe; Jun Mizuguchi; Chikateru Nozaki; Tomohiro Nakagaki; S Miyamoto; A Funatsu; Sadaaki Iwanaga
Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.
Thrombosis research 2001;102(4):363-74.
1998: H Kaetsu; Jun Mizuguchi; T Hamamoto; K Kamimura; Y Yoshida; Tomohiro Nakagaki; Y Ogata; S Miyamoto; A Funatsu
Large-scale preparation of human thrombin: polyethylene glycol potentiates the factor Xa-mediated activation of prothrombin.
Thrombosis research 1998;90(3):101-9.
1998: Yuichi Kamikubo; Tsutomu Hamuro; S Takemoto; Yo Nakahara; S Kamei; Tomohiro Nakagaki; S Miyamoto; A Funatsu; H Kato
A kinetic analysis of the interaction of human recombinant tissue factor pathway inhibitor with factor Xa utilizing and immunoassay and the effect of antithrombin III/heparin on the complex formation.
Thrombosis research 1998;89(4):179-86.
1996: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; M Johno; Tomohiro Nakagaki; H Okabe; Kiyoshi Takatsuki
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Blood 1996;87(2):642-7.
1994: M M Khan; Yoko Shibuya; Tomohiro Nakagaki; T Kambara; T Yamamoto
Alpha-2-macroglobulin as the major defence in acute pseudomonal septic shock in the guinea-pig model.
International journal of experimental pathology 1994;75(4):285-93.
1994: S Nomura; S Fukuhara; Y Komiyama; H Takahashi; E Matsuura; Tomohiro Nakagaki; A Funatsu; T Sugo; M Matsuda; T Koike
beta 2-Glycoprotein I and anticardiolipin antibody influence factor Xa generation but not factor Xa binding to platelet-derived microparticles.
Thrombosis and haemostasis 1994;71(4):526-7.
1992: P Wildgoose; T Jørgensen; Y Komiyama; Tomohiro Nakagaki; A Pedersen; W Kisiel
The role of phospholipids and the factor VII Gla-domain in the interaction of factor VII with tissue factor.
Thrombosis and haemostasis 1992;67(6):679-85.
1990: Kenji Okajima; S Koga; M Kaji; M Inoue; Tomohiro Nakagaki; A Funatsu; H Okabe; Kiyoshi Takatsuki; N Aoki
Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects.
Thrombosis and haemostasis 1990;63(1):48-53.
1989: Kenji Okajima; S Koga; Tomohiro Nakagaki; H Okabe; A Funatsu; Kiyoshi Takatsuki
[Role of protein C in endotoxin-induced release of plasminogen activator inhibitor from endothelial cell].
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society 1989;52(7):1159-64.