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Takahiko Nakagawa

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Waichi Sato; Katsuyuki Tanabe; Li Zhang; Charles E Alpers; Martha Campbell-Thompson; Kelly Hudkins; Tomoki Kosugi; Miguel A Lanaspa; Qiuhong Li; David A Long; Takahiko Nakagawa
Selective stimulation of VEGFR2 accelerates progressive renal disease.
Takahiro Nakayama; Waichi Sato; Ashio Yoshimura; Li Zhang; Tomoki Kosugi; Martha Campbell-Thompson; Hideto Kojima; Byron P Croker; Takahiko Nakagawa
Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.
Tomoki Kosugi; Marcelo Heinig; Takahiro Nakayama; Seiichi Matsuo; Takahiko Nakagawa
eNOS knockout mice with advanced diabetic nephropathy have less benefit from renin-angiotensin blockade than from aldosterone receptor antagonists.

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2011: Waichi Sato; Katsuyuki Tanabe; Li Zhang; Charles E Alpers; Martha Campbell-Thompson; Kelly Hudkins; Tomoki Kosugi; Miguel A Lanaspa; Qiuhong Li; David A Long; Takahiko Nakagawa
Selective stimulation of VEGFR2 accelerates progressive renal disease.
The American journal of pathology 2011;179(1):155-66.
2010: Takahiro Nakayama; Waichi Sato; Ashio Yoshimura; Li Zhang; Tomoki Kosugi; Martha Campbell-Thompson; Hideto Kojima; Byron P Croker; Takahiko Nakagawa
Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.
The American journal of pathology 2010;176(5):2198-208.
2010: Tomoki Kosugi; Marcelo Heinig; Takahiro Nakayama; Seiichi Matsuo; Takahiko Nakagawa
eNOS knockout mice with advanced diabetic nephropathy have less benefit from renin-angiotensin blockade than from aldosterone receptor antagonists.
The American journal of pathology 2010;176(2):619-29.
2010: Laura G Sánchez-Lozada; Wei Mu; Carlos Roncal; Sautin Yuri; Manal F Abdelmalek; Sirirat Reungjui; MyPhuong Le; Takahiko Nakagawa; Hui Y Lan; Xuequing Yu; Richard J Johnson
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver.
European journal of nutrition 2010;49(1):1-9.
2009: Tomoki Kosugi; Takahiro Nakayama; Marcelo Heinig; Li Zhang; Yukio Yuzawa; Laura Gabriela Sanchez-Lozada; Carlos Roncal; Richard J Johnson; Takahiko Nakagawa
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice.
American journal of physiology. Renal physiology 2009;297(2):F481-8.
2009: Richard J Johnson; Santos E Perez-Pozo; Sautin Yuri; Jacek Manitius; Laura Gabriela Sanchez-Lozada; Daniel I Feig; Mohamed Shafiu; Mark Segal; Richard J Glassock; Michiko Shimada; Carlos Roncal; Takahiko Nakagawa
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Endocrine reviews 2009;30(1):96-116.
2009: Richard J Johnson; Sautin Yuri; William J Oliver; Carlos Roncal; Wei Mu; L Gabriela Sanchez-Lozada; Bernardo Rodriguez-Iturbe; Takahiko Nakagawa; Steven A Benner
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2009;179(1):67-76.
2008: Takahiko Nakagawa; Pietro Cirillo; Waichi Sato; Michael S Gersch; Sautin Yuri; Carlos Roncal; Wei Mu; Laura G Sánchez-Lozada; Richard J Johnson
The conundrum of hyperuricemia, metabolic syndrome, and renal disease.
Internal and emergency medicine 2008;3(4):313-8.
2008: Takahiko Nakagawa
Uncoupling of VEGF with NO as a mechanism for diabetic nephropathy.
Diabetes research and clinical practice 2008;82 Suppl 1():S67-9.
2008: Sirirat Reungjui; Thongchai Pratipanawatr; Richard J Johnson; Takahiko Nakagawa
Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia.
Current opinion in nephrology and hypertension 2008;17(5):470-6.
2008: Waichi Sato; Tomoki Kosugi; Li Zhang; Carlos A Roncal; Marcelo Heinig; Martha Campbell-Thompson; Yukio Yuzawa; Mark A Atkinson; Maria B Grant; Byron P Croker; Takahiko Nakagawa
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology 2008;88(9):949-61.
2008: Sergio Li Calzi; Daniel L Purich; Kyung Hee Chang; Aqeela Afzal; Takahiko Nakagawa; Julia V Busik; Anupam Agarwal; Mark S Segal; Maria B Grant
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes 2008;57(9):2488-94.
2008: Olena Y Glushakova; Tomoki Kosugi; Carlos Roncal; Wei Mu; Marcelo Heinig; Pietro Cirillo; Laura G Sánchez-Lozada; Richard J Johnson; Takahiko Nakagawa
Fructose induces the inflammatory molecule ICAM-1 in endothelial cells.
Journal of the American Society of Nephrology : JASN 2008;19(9):1712-20.
2008: Richard J Johnson; Daniel I Feig; Takahiko Nakagawa; L Gabriela Sanchez-Lozada; Bernardo Rodriguez-Iturbe
Pathogenesis of essential hypertension: historical paradigms and modern insights.
Journal of hypertension 2008;26(3):381-91.
2008: Sirirat Reungjui; Carlos Roncal; Waichi Sato; Olena Y Glushakova; Byron P Croker; Shin-Ichi Suga; Xiaosen Ouyang; Kriang Tungsanga; Takahiko Nakagawa; Richard J Johnson; Wei Mu
Hypokalemic nephropathy is associated with impaired angiogenesis.
Journal of the American Society of Nephrology : JASN 2008;19(1):125-34.
2007: Sirirat Reungjui; H Hu; Wei Mu; Carlos Roncal; Byron P Croker; Jawaharlal M Patel; Takahiko Nakagawa; Titte R Srinivas; Karen J Byer; J Simoni; D Wesson; V Sitprija; Richard J Johnson
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Kidney international 2007;72(12):1483-92.
2007: Richard J Johnson; Mark S Segal; Sautin Yuri; Takahiko Nakagawa; Daniel I Feig; Duk-Hee Kang; Michael S Gersch; Steven Benner; Laura G Sánchez-Lozada
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
The American journal of clinical nutrition 2007;86(4):899-906.
2007: Sirirat Reungjui; Carlos Roncal; Wei Mu; Titte R Srinivas; Dhavee Sirivongs; Richard J Johnson; Takahiko Nakagawa
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Journal of the American Society of Nephrology : JASN 2007;18(10):2724-31.
2007: Carlos Roncal; Wei Mu; Sirirat Reungjui; Kyung Mee Kim; George N Henderson; Xiaosen Ouyang; Takahiko Nakagawa; Richard J Johnson
Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease.
American journal of physiology. Renal physiology 2007;293(4):F1391-6.
2007: Michael S Gersch; Wei Mu; Pietro Cirillo; Sirirat Reungjui; Li Zhang; Carlos Roncal; Sautin Yuri; Richard J Johnson; Takahiko Nakagawa
Fructose, but not dextrose, accelerates the progression of chronic kidney disease.
American journal of physiology. Renal physiology 2007;293(4):F1256-61.
2007: Takahiko Nakagawa; Mark Segal; Byron P Croker; Richard J Johnson
A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(10):2775-7.
2007: Sautin Yuri; Takahiko Nakagawa; Sergey Zharikov; Richard J Johnson
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress.
American journal of physiology. Cell physiology 2007;293(2):C584-96.
2007: Takahiko Nakagawa
Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease.
American journal of physiology. Renal physiology 2007;292(6):F1665-72.
2007: Takahiko Nakagawa; Waichi Sato; Olena Y Glushakova; Marcelo Heinig; Tracy Clarke; Martha Campbell-Thompson; Yukio Yuzawa; Mark A Atkinson; Richard J Johnson; Byron P Croker
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2007;18(2):539-50.
2007: A Ahsan Ejaz; Wei Mu; Duk-Hee Kang; Carlos Roncal; Sautin Yuri; George Henderson; Isabelle Tabah-Fisch; Birgit Keller; Thomas M Beaver; Takahiko Nakagawa; Richard J Johnson
Could uric acid have a role in acute renal failure?
Clinical journal of the American Society of Nephrology : CJASN 2007;2(1):16-21.
2006: Pietro Cirillo; Waichi Sato; Sirirat Reungjui; Marcelo Heinig; Michael S Gersch; Sautin Yuri; Takahiko Nakagawa; Richard J Johnson
Uric acid, the metabolic syndrome, and renal disease.
Journal of the American Society of Nephrology : JASN 2006;17(12 Suppl 3):S165-8.
2006: Daniel I Feig; Duk-Hee Kang; Takahiko Nakagawa; Marilda Mazzali; Richard J Johnson
Uric acid and hypertension.
Current hypertension reports 2006;8(2):111-5.
2006: Takahiko Nakagawa; Duk-Hee Kang; Daniel I Feig; L G Sanchez-Lozada; Titte R Srinivas; Sautin Yuri; A Ahsan Ejaz; M Segal; Richard J Johnson
Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.
Kidney international 2006;69(10):1722-5.
2006: Daniel I Feig; Marilda Mazzali; Duk-Hee Kang; Takahiko Nakagawa; Karen Price; John Kannelis; Richard J Johnson
Serum uric acid: a risk factor and a target for treatment?
Journal of the American Society of Nephrology : JASN 2006;17(4 Suppl 2):S69-73.
2006: Takahiko Nakagawa; Waichi Sato; Sautin Yuri; Olena Y Glushakova; Byron P Croker; Mark A Atkinson; C Craig Tisher; Richard J Johnson
Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.
Journal of the American Society of Nephrology : JASN 2006;17(3):736-45.
2006: Takahiko Nakagawa; Hanbo Hu; Sergey Zharikov; Katherine R Tuttle; Robert A Short; Olena Y Glushakova; Xiaosen Ouyang; Daniel I Feig; Edward R Block; Jaime Herrera-Acosta; Jawaharlal M Patel; Richard J Johnson
A causal role for uric acid in fructose-induced metabolic syndrome.
American journal of physiology. Renal physiology 2006;290(3):F625-31.
2006: Takahiko Nakagawa; Marilda Mazzali; Duk-Hee Kang; Laura G Sánchez-Lozada; Jaime Herrera-Acosta; Richard J Johnson
Uric acid--a uremic toxin?
Blood purification 2006;24(1):67-70.
2005: Takahiko Nakagawa; Katherine R Tuttle; Robert A Short; Richard J Johnson
Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome.
Nature clinical practice. Nephrology 2005;1(2):80-6.
2005: Uday M Khosla; Sergey Zharikov; Jennifer L Finch; Takahiko Nakagawa; Carlos Roncal; Wei Mu; Karina Y Krotova; Edward R Block; Sharma Prabhakar; Richard J Johnson
Hyperuricemia induces endothelial dysfunction.
Kidney international 2005;67(5):1739-42.
2005: Takahiko Nakagawa; Hui Y Lan; Olena Y Glushakova; Hong J Zhu; Duk-Hee Kang; George F Schreiner; Erwin P Böttinger; Richard J Johnson; Sautin Yuri
Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.
Journal of the American Society of Nephrology : JASN 2005;16(4):899-904.
2005: Richard J Johnson; Bernardo Rodriguez-Iturbe; Takahiko Nakagawa; Duk-Hee Kang; Daniel I Feig; Jaime Herrera-Acosta
Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension.
Hypertension 2005;45(3):326-30.
2004: Takahiko Nakagawa; Hui Y Lan; Hong J Zhu; Duk-Hee Kang; George F Schreiner; Richard J Johnson
Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells.
American journal of physiology. Renal physiology 2004;287(4):F658-64.
2004: Takahiko Nakagawa; Jin H Li; Gabriela Garcia; Wei Mu; Ester Piek; Erwin P Böttinger; Yan Chen; Hong-Jian Zhu; Duk-Hee Kang; George F Schreiner; Hui Y Lan; Richard J Johnson
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways.
Kidney international 2004;66(2):605-13.
2004: Daniel I Feig; Takahiko Nakagawa; S Ananth Karumanchi; William J Oliver; Duk-Hee Kang; Jennifer Finch; Richard J Johnson
Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension.
Kidney international 2004;66(1):281-7.
2004: Ryuji Ohashi; Takahiko Nakagawa; Susumu Watanabe; John Kanellis; Ramona G Almirez; George F Schreiner; Richard J Johnson
Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway.
The American journal of pathology 2004;164(2):477-85.
2003: John Kanellis; Susumu Watanabe; Jin H Li; Duk Hee Kang; Ping Li; Takahiko Nakagawa; Ann Wamsley; David Sheikh-Hamad; Hui Y Lan; Lili Feng; Richard J Johnson
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.
Hypertension 2003;41(6):1287-93.
2003: Takahiko Nakagawa; Duk-Hee Kang; Ryuji Ohashi; Shin-ichi Suga; Jaime Herrera-Acosta; Bernardo Rodriguez-Iturbe; Richard J Johnson
Tubulointerstitial disease: role of ischemia and microvascular disease.
Current opinion in nephrology and hypertension 2003;12(3):233-41.
2002: Duk-Hee Kang; Takahiko Nakagawa; Lili Feng; Susumu Watanabe; Lin Han; Marilda Mazzali; Luan Truong; Raymond Harris; Richard J Johnson
A role for uric acid in the progression of renal disease.
Journal of the American Society of Nephrology : JASN 2002;13(12):2888-97.
2002: Susumu Watanabe; Duk-Hee Kang; Lili Feng; Takahiko Nakagawa; John Kanellis; Hui Lan; Marilda Mazzali; Richard J Johnson
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity.
Hypertension 2002;40(3):355-60.
2002: Duk-Hee Kang; Takahiko Nakagawa; Lili Feng; Richard J Johnson
Nitric oxide modulates vascular disease in the remnant kidney model.
The American journal of pathology 2002;161(1):239-48.
2002: Marilda Mazzali; John Kanellis; Lin Han; Lili Feng; Yi-Yang Xia; Qiang Chen; Duk-Hee Kang; Katherine L Gordon; Susumu Watanabe; Takahiko Nakagawa; Hui Y Lan; Richard J Johnson
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
American journal of physiology. Renal physiology 2002;282(6):F991-7.