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Akira Nakagawara

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Neuroblastoma

Chemicals & Drugs

Genes & Molecular Sequences

Tumor Suppressor Genes

Anatomy

Concepts & Ideas

Molecular Sequence Data

Physiology

Living Beings

Mice
Infant

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Co-Publications
Name
62
Ozaki, Toshinori
33
Sakiyama, Shigeru
31
Ohira, Miki
25
Nakamura, Yohko
15
Todo, Satoru
14
Takahashi, Masato
13
Shishikura, Tomotane
12
Kageyama, Hajime
11
Yamamoto, Hideki
10
Miyazaki, Kou
9
Nakagawa, Takahito
9
Hosoda, Mitsuchika
9
Takada, N
8
Takayasu, Hajime
8
Kaneko, Yasuhiko

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Publications

TOP 3
Ozaki Toshinori; Okoshi Rintaro; Ono Sayaka; Kubo Natsumi; Nakagawara Akira
Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity.
Ozaki Toshinori; Okoshi Rintaro; Sang Meixiang; Kubo Natsumi; Nakagawara Akira
Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73.
Sang Meixiang; Ando Kiyohiro; Okoshi Rintaro; Koida Nami; Li Yuanyuan; Zhu Yuyan; Shimozato Osamu; Geng Cuizhi; Shan Baoen; Nakagawara Akira; Ozaki Toshinori
Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.

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All Publications

2009: Ozaki Toshinori; Okoshi Rintaro; Ono Sayaka; Kubo Natsumi; Nakagawara Akira
Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity.
Biochemical and biophysical research communications 2009;387(1):143-8.
2009: Ozaki Toshinori; Okoshi Rintaro; Sang Meixiang; Kubo Natsumi; Nakagawara Akira
Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73.
Biochemical and biophysical research communications 2009;386(1):207-11.
2009: Sang Meixiang; Ando Kiyohiro; Okoshi Rintaro; Koida Nami; Li Yuanyuan; Zhu Yuyan; Shimozato Osamu; Geng Cuizhi; Shan Baoen; Nakagawara Akira; Ozaki Toshinori
Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(7):775-88.
2009: Haraguchi Seiki; Nakagawara Akira
A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse.
PloS one 2009;4(9):e6902.
2008: Ando Kiyohiro; Ohira Miki; Ozaki Toshinori; Nakagawa Atsuko; Akazawa Kohei; Suenaga Yusuke; Nakamura Yohko; Koda Tadayuki; Kamijo Takehiko; Murakami Yoshinori; Nakagawara Akira
Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation.
International journal of cancer. Journal international du cancer 2008;123(9):2087-94.
2008: Hossain M S; Ozaki T; Wang H; Nakagawa A; Takenobu H; Ohira M; Kamijo T; Nakagawara A
N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma.
Oncogene 2008;27(46):6075-82.
2008: Munirajan Arasambattu K; Ando Kiyohiro; Mukai Akira; Takahashi Masato; Suenaga Yusuke; Ohira Miki; Koda Tadayuki; Hirota Toru; Ozaki Toshinori; Nakagawara Akira
KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.
The Journal of biological chemistry 2008;283(36):24426-34.
2008: Inoue Ken-Ichi; Nakanjishi Mitsuru; Kikuchi Hironobu; Yamamoto Hideki; Todo Satoru; Nakagawara Akira; Ozaki Toshinori
NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage.
Biochemical and biophysical research communications 2008;371(4):829-33.
2008: Arai Hiroshi; Ozaki Toshinori; Niizuma Hidetaka; Nakamura Yohko; Ohira Miki; Takano Kunio; Matsumoto Masahiko; Nakagawara Akira
ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid.
Oncology reports 2008;19(6):1381-8.
2008: Wang Hong; Ozaki Toshinori; Shamim Hossain M; Nakamura Yohko; Kamijo Takehiko; Xue Xindong; Nakagawara Akira
A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53.
Biochemical and biophysical research communications 2008;370(4):594-8.
2008: Li Y; Ozaki T; Kikuchi H; Yamamoto H; Ohira M; Nakagawara A
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner.
Oncogene 2008;27(26):3700-9.
2008: Ichikawa Tomoe; Suenaga Yusuke; Koda Tadayuki; Ozaki Toshinori; Nakagawara Akira
DeltaNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding.
Biochemical and biophysical research communications 2008;369(4):994-1000.
2008: Koida Nami; Ozaki Toshinori; Yamamoto Hideki; Ono Sayaka; Koda Tadayuki; Ando Kiyohiro; Okoshi Rintaro; Kamijo Takehiko; Omura Ken; Nakagawara Akira
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.
The Journal of biological chemistry 2008;283(13):8555-63.
2008: Okoshi Rintaro; Ozaki Toshinori; Yamamoto Hideki; Ando Kiyohiro; Koida Nami; Ono Sayaka; Koda Tadayuki; Kamijo Takehiko; Nakagawara Akira; Kizaki Harutoshi
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress.
The Journal of biological chemistry 2008;283(7):3979-87.
2008: Yoshida K; Ozaki T; Furuya K; Nakanishi M; Kikuchi H; Yamamoto H; Ono S; Koda T; Omura K; Nakagawara A
ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin.
Oncogene 2008;27(8):1183-8.
2008: Bu Youquan; Suenaga Yusuke; Ono Sayaka; Koda Tadayuki; Song Fangzhou; Nakagawara Akira; Ozaki Toshinori
Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(1):53-66.
2008: Ichikawa T; Suenaga Y; Koda T; Ozaki T; Nakagawara A
TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation.
Oncogene 2008;27(4):409-20.
2008: Tomioka N; Oba S; Ohira M; Misra A; Fridlyand J; Ishii S; Nakamura Y; Isogai E; Hirata T; Yoshida Y; Todo S; Kaneko Y; Albertson D G; Pinkel D; Feuerstein B G; Nakagawara A
Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature.
Oncogene 2008;27(4):441-9.
2007: Nakanishi Mitsuru; Ozaki Toshinori; Yamamoto Hideki; Hanamoto Takayuki; Kikuchi Hironobu; Furuya Kazushige; Asaka Masahiro; Delia Domenico; Nakagawara Akira
NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage.
The Journal of biological chemistry 2007;282(31):22993-3004.
2007: Takahashi M; Ozaki T; Takahashi A; Miyauchi M; Ono S; Takada N; Koda T; Todo S; Kamijo T; Nakagawara A
DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not DNA cleavage in DFF45-deficient neuroblastoma cells.
Oncogene 2007;26(38):5669-73.
2007: Nakanishi Hiroko; Ozaki Toshinori; Nakamura Youko; Hashizume Kohei; Iwanaka Tadashi; Nakagawara Akira
Purification of human primary neuroblastomas by magnetic beads and their in vitro culture.
Oncology reports 2007;17(6):1315-20.
2007: Nimura Yoshinori; Kawata Tetsuya; Uzawa Katsuhiro; Okamura Junko; Liu Cuihua; Saito Masayoshi; Shimada Hideaki; Seki Naohiko; Nakagawara Akira; Ito Hisao; Ochiai Takenori; Tanzawa Hideki
Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo.
International journal of oncology 2007;30(6):1477-84.
2007: Furuya Kazushige; Ozaki Toshinori; Hanamoto Takayuki; Hosoda Mitsuchika; Hayashi Syunji; Barker Philip A; Takano Kunio; Matsumoto Masahiko; Nakagawara Akira
Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.
The Journal of biological chemistry 2007;282(25):18365-78.
2007: Yamamoto Hideki; Ozaki Toshinori; Nakanishi Mitsuru; Kikuchi Hironobu; Yoshida Kaori; Horie Hiroshi; Kuwano Hiroyuki; Nakagawara Akira
Oxidative stress induces p53-dependent apoptosis in hepatoblastoma cell through its nuclear translocation.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(4):461-71.
2007: Nakamura Yohko; Ozaki Toshinori; Niizuma Hidetaka; Ohira Miki; Kamijo Takehiko; Nakagawara Akira
Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line.
Biochemical and biophysical research communications 2007;354(4):892-8.
2007: Tomizawa Minoru; Horie Hiroshi; Yamamoto Hideki; Matsunaga Tadashi; Sasaki Fumiaki; Hashizume Kohei; Hiyama Eiso; Kaneko Michio; Suita Sachiyo; Ando Hisami; Hayashi Yutaka; Ohnuma Naomi; Nakagawara Akira
Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance.
Oncology reports 2007;17(2):341-4.
2006: Ozaki Toshinori; Li Yuanyuan; Kikuchi Hironobu; Tomita Taisuke; Iwatsubo Takeshi; Nakagawara Akira
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
Biochemical and biophysical research communications 2006;351(1):57-63.
2006: Kikuchi H; Ozaki T; Furuya K; Hanamoto T; Nakanishi M; Yamamoto H; Yoshida K; Todo S; Nakagawara A
NF-kappaB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway.
Oncogene 2006;25(58):7608-17.
2006: Hayashi Syunji; Ozaki Toshinori; Yoshida Kaori; Hosoda Mitsuchika; Todo Satoru; Akiyama Shin-ichi; Nakagawara Akira
p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53.
Biochemical and biophysical research communications 2006;347(1):60-6.
2006: Sang Meixiang; Li Yuanyuan; Ozaki Toshinori; Ono Sayaka; Ando Kiyohiro; Yamamoto Hideki; Koda Tadayuki; Geng Cuizhi; Nakagawara Akira
p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers.
Biochemical and biophysical research communications 2006;347(1):327-33.
2006: Niizuma H; Nakamura Y; Ozaki T; Nakanishi H; Ohira M; Isogai E; Kageyama H; Imaizumi M; Nakagawara A
Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma.
Oncogene 2006;25(36):5046-55.
2006: Machida T; Fujita T; Ooo M L; Ohira M; Isogai E; Mihara M; Hirato J; Tomotsune D; Hirata T; Fujimori M; Adachi W; Nakagawara A
Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.
Oncogene 2006;25(13):1931-42.
2005: Ozaki Toshinori; Nakagawara Akira
p73, a sophisticated p53 family member in the cancer world.
Cancer science 2005;96(11):729-37.
2005: Hosoda Mitsuchika; Ozaki Toshinori; Miyazaki Kou; Hayashi Syunji; Furuya Kazushige; Watanabe Ken-Ichi; Nakagawa Takahito; Hanamoto Takayuki; Todo Satoru; Nakagawara Akira
UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination.
Oncogene 2005;24(48):7156-69.
2005: Ohira Miki; Oba Shigeyuki; Nakamura Yoko; Hirata Takahiro; Ishii Shin; Nakagawara Akira
A review of DNA microarray analysis of human neuroblastomas.
Cancer letters 2005;228(1-2):5-11.
2005: Ozaki Toshinori; Hosoda Mitsuchika; Miyazaki Kou; Hayashi Syunji; Watanabe Ken-Ichi; Nakagawa Takahito; Nakagawara Akira
Functional implication of p73 protein stability in neuronal cell survival and death.
Cancer letters 2005;228(1-2):29-35.
2005: Aoyama Mineyoshi; Ozaki Toshinori; Inuzuka Hiroyuki; Tomotsune Daihachiro; Hirato Junko; Okamoto Yoshiaki; Tokita Hisashi; Ohira Miki; Nakagawara Akira
LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
Cancer research 2005;65(11):4587-97.
2005: Lin Ling; Ozaki Toshinori; Takada Yuki; Kageyama Hajime; Nakamura Yoko; Hata Akira; Zhang Jian-Hua; Simonds William F; Nakagawara Akira; Koseki Haruhiko
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Oncogene 2005;24(21):3385-96.
2005: Ohira Miki; Oba Shigeyuki; Nakamura Yohko; Isogai Eriko; Kaneko Setsuko; Nakagawa Atsuko; Hirata Takahiro; Kubo Hiroyuki; Goto Takeshi; Yamada Saichi; Yoshida Yasuko; Fuchioka Misa; Ishii Shin; Nakagawara Akira
Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas.
Cancer cell 2005;7(4):337-50.
2005: Hanamoto Takayuki; Ozaki Toshinori; Furuya Kazushige; Hosoda Mitsuchika; Hayashi Syunji; Nakanishi Mitsuru; Yamamoto Hideki; Kikuchi Hironobu; Todo Satoru; Nakagawara Akira
Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function.
The Journal of biological chemistry 2005;280(17):16665-75.
2005: Kramer Sonja; Ozaki Toshinori; Miyazaki Kou; Kato Chiaki; Hanamoto Takayuki; Nakagawara Akira
Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.
Oncogene 2005;24(5):938-44.
2004: Kato Chiaki; Miyazaki Kou; Nakagawa Atsuko; Ohira Miki; Nakamura Yohko; Ozaki Toshinori; Imai Toshio; Nakagawara Akira
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
International journal of cancer. Journal international du cancer 2004;112(3):365-75.
2004: Takahashi Masato; Ozaki Toshinori; Todo Satoru; Nakagawara Akira
Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas.
Oncology reports 2004;12(4):811-6.
2004: Yamada Shin-ichi; Ohira Miki; Horie Hiroshi; Ando Kiyohiro; Takayasu Hajime; Suzuki Yutaka; Sugano Sumio; Hirata Takahiro; Goto Takeshi; Matsunaga Tadashi; Hiyama Eiso; Hayashi Yutaka; Ando Hisami; Suita Sachiyo; Kaneko Michio; Sasaki Fumiaki; Hashizume Kohei; Ohnuma Naomi; Nakagawara Akira
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
Oncogene 2004;23(35):5901-11.
2004: Wang Yanqing; Seimiya Mika; Kawamura Kiyoko; Yu Ling; Ogi Tomoo; Takenaga Keizo; Shishikura Tomotane; Nakagawara Akira; Sakiyama Shigeru; Tagawa Masatoshi; O-Wang Jiyang
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
International journal of oncology 2004;25(1):161-5.
2004: Hamano Shiho; Ohira Miki; Isogai Eriko; Nakada Kounosuke; Nakagawara Akira
Identification of novel human neuronal leucine-rich repeat (hNLRR) family genes and inverse association of expression of Nbla10449/hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas.
International journal of oncology 2004;24(6):1457-66.
2004: Ando Kiyohiro; Ozaki Toshinori; Yamamoto Hideki; Furuya Kazushige; Hosoda Mitsuchika; Hayashi Syunji; Fukuzawa Masahiro; Nakagawara Akira
Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.
The Journal of biological chemistry 2004;279(24):25549-61.
2004: Miyazaki Kou; Fujita Tomoyuki; Ozaki Toshinori; Kato Chiaki; Kurose Yuka; Sakamoto Maya; Kato Shinsuke; Goto Takeshi; Itoyama Yasuto; Aoki Masashi; Nakagawara Akira
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.
The Journal of biological chemistry 2004;279(12):11327-35.
2004: Nakagawara Akira; Ohira Miki
Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model.
Cancer letters 2004;204(2):213-24.
2004: Nakagawara Akira
Neural crest development and neuroblastoma: the genetic and biological link.
Progress in brain research 2004;146():233-42.
2003: Ohira Miki; Morohashi Aiko; Inuzuka Hiroyuki; Shishikura Tomotane; Kawamoto Takemasa; Kageyama Hajime; Nakamura Yohko; Isogai Eriko; Takayasu Hajime; Sakiyama Shigeru; Suzuki Yutaka; Sugano Sumio; Goto Takeshi; Sato Shuji; Nakagawara Akira
Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets.
Oncogene 2003;22(35):5525-36.
2003: Miyazaki Kou; Ozaki Toshinori; Kato Chiaki; Hanamoto Takayuki; Fujita Tomoyuki; Irino Shigemi; Watanabe Ken-ichi; Nakagawa Takahito; Nakagawara Akira
A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.
Biochemical and biophysical research communications 2003;308(1):106-13.
2003: Nakagawa Takahito; Takahashi Masato; Ozaki Toshinori; Watanabe Ken-ichi; Hayashi Shunji; Hosoda Mitsuchika; Todo Satoru; Nakagawara Akira
Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells.
Cancer letters 2003;197(1-2):105-9.
2003: Ohira Miki; Morohashi Aiko; Nakamura Yohko; Isogai Eriko; Furuya Kazushige; Hamano Shiho; Machida Taiichi; Aoyama Mineyoshi; Fukumura Masayuki; Miyazaki Kou; Suzuki Yutaka; Sugano Sumio; Hirato Junko; Nakagawara Akira
Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.
Cancer letters 2003;197(1-2):63-8.
2003: Okamoto Yoshiaki; Ozaki Toshinori; Miyazaki Kou; Aoyama Mineyoshi; Miyazaki Masaru; Nakagawara Akira
UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.
Cancer research 2003;63(14):4167-73.
2003: Nakamura Yohko; Ozaki Toshinori; Koseki Haruhiko; Nakagawara Akira; Sakiyama Shigeru
Accumulation of p27 KIP1 is associated with BMP2-induced growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines.
Biochemical and biophysical research communications 2003;307(1):206-13.
2003: Ozaki Toshinori; Watanabe Ken-ichi; Nakagawa Takahito; Miyazaki Kou; Takahashi Masato; Nakagawara Akira
Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.
Oncogene 2003;22(21):3231-42.
2003: Kawamoto T; Ohira M; Hamano S; Hori T; Nakagawara A
High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas.
International journal of oncology 2003;22(4):815-22.
2003: Tomioka Nobumoto; Kobayashi Hirofumi; Kageyama Hajime; Ohira Miki; Nakamura Yohko; Sasaki Fumiaki; Todo Satoru; Nakagawara Akira; Kaneko Yasuhiko
Chromosomes that show partial loss or gain in near-diploid tumors coincide with chromosomes that show whole loss or gain in near-triploid tumors: evidence suggesting the involvement of the same genes in the tumorigenesis of high- and low-risk neuroblastomas.
Genes, chromosomes & cancer 2003;36(2):139-50.
2003: Tomizawa Minoru; Watanabe Kazuo; Saisho Hiromitsu; Nakagawara Akira; Tagawa Masatoshi
Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker.
Anticancer research 2003;23(1A):351-4.
2002: Iuchi Toshihiko; Namba Hiroki; Iwadate Yasuo; Shishikura Tomotane; Kageyama Hajime; Nakamura Yoko; Ohira Miki; Yamaura Akira; Osato Katsunobu; Sakiyama Shigeru; Nakagawara Akira
Identification of the small interstitial deletion at chromosome band 1p34-p35 and its association with poor outcome in oligodendroglial tumors.
Genes, chromosomes & cancer 2002;35(2):170-5.
2002: Shinbo Jun; Ozaki Toshinori; Nakagawa Takahito; Watanabe Ken-ichi; Nakamura Yohko; Yamazaki Masashi; Moriya Hideshige; Nakagawara Akira; Sakiyama Shigeru
p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation.
Biochemical and biophysical research communications 2002;295(2):501-7.
2002: Tomizawa Minoru; Wang Yan-Qing; Ebara Masaaki; Saisho Hiromitsu; Watanabe Kazuo; Nakagawara Akira; Tagawa Masatoshi
Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas.
International journal of molecular medicine 2002;9(6):597-600.
2002: Takahashi Masato; Seki Naohiko; Ozaki Toshinori; Kato Masaki; Kuno Tomoko; Nakagawa Takahito; Watanabe Ken-ichi; Miyazaki Koh; Ohira Miki; Hayashi Shunji; Hosoda Mitsuchika; Tokita Hisashi; Mizuguchi Hiroyuki; Hayakawa Takao; Todo Satoru; Nakagawara Akira
Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.
Cancer research 2002;62(8):2203-9.
2002: Nakagawa Takahito; Takahashi Masato; Ozaki Toshinori; Watanabe Ki Ken-ichi; Todo Satoru; Mizuguchi Hiroyuki; Hayakawa Takao; Nakagawara Akira
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.
Molecular and cellular biology 2002;22(8):2575-85.
2002: Watanabe Ken-ichi; Ozaki Toshinori; Nakagawa Takahito; Miyazaki Kou; Takahashi Masato; Hosoda Mitsuchika; Hayashi Syunji; Todo Satoru; Nakagawara Akira
Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.
The Journal of biological chemistry 2002;277(17):15113-23.
2001: Nakagawara A
Trk receptor tyrosine kinases: a bridge between cancer and neural development.
Cancer letters 2001;169(2):107-14.
2001: Naka M; Ozaki T; Takada N; Takahashi M; Shishikura T; Sakiyama S; Tada M; Todo S; Nakagawara A
Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer.
Oncogene 2001;20(27):3568-72.
2001: Takayasu H; Horie H; Hiyama E; Matsunaga T; Hayashi Y; Watanabe Y; Suita S; Kaneko M; Sasaki F; Hashizume K; Ozaki T; Furuuchi K; Tada M; Ohnuma N; Nakagawara A
Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):901-8.
2001: Miyauchi M; Yoshida Y; Tada Y; Narita M; Maeda T; Bahar R; Kadomatsu K; Muramatsu T; Matsubara S; Nakagawara A; Sakiyama S; Tagawa M
Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells.
International journal of cancer. Journal international du cancer 2001;91(5):723-7.
2001: Ichimiya S; Nimura Y; Kageyama H; Takada N; Sunahara M; Shishikura T; Nakamura Y; Sakiyama S; Seki N; Ohira M; Kaneko Y; McKeon F; Caput D; Nakagawara A
Genetic analysis of p73 localized at chromosome 1p36.3 in primary neuroblastomas.
Medical and pediatric oncology 2001;36(1):42-4.
2001: Ichimiya S; Nimura Y; Seki N; Ozaki T; Nagase T; Nakagawara A
Downregulation of hASH1 is associated with the retinoic acid-induced differentiation of human neuroblastoma cell lines.
Medical and pediatric oncology 2001;36(1):132-4.
2001: Takada N; Isogai E; Kawamoto T; Nakanishi H; Todo S; Nakagawara A
Retinoic acid-induced apoptosis of the CHP134 neuroblastoma cell line is associated with nuclear accumulation of p53 and is rescued by the GDNF/Ret signal.
Medical and pediatric oncology 2001;36(1):122-6.
2001: Kawamura K; O-Wang J; Bahar R; Koshikawa N; Shishikura T; Nakagawara A; Sakiyama S; Kajiwara K; Kimura M; Tagawa M
The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues.
International journal of oncology 2001;18(1):97-103.
2000: Kawamoto T; Shishikura T; Ohira M; Takayasu H; Morohashi A; Takada N; Takahashi M; Suzuki Y; Sugano S; Hori T; Nakagawara A
Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene, nbla3145/XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries.
Medical and pediatric oncology 2000;35(6):628-31.
2000: Islam A; Kageyama H; Hashizume K; Kaneko Y; Nakagawara A
Role of survivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform, survivin-beta/2B.
Medical and pediatric oncology 2000;35(6):550-3.
2000: Ohira M; Shishikura T; Kawamoto T; Inuzuka H; Morohashi A; Takayasu H; Kageyama H; Takada N; Takahashi M; Sakiyama S; Suzuki Y; Sugano S; Kuma H; Nozawa I; Nakagawara A
Hunting the subset-specific genes of neuroblastoma: expression profiling and differential screening of the full-length-enriched oligo-capping cDNA libraries.
Medical and pediatric oncology 2000;35(6):547-9.
2000: Nakagawara A; Ohira M; Kageyama H; Mihara M; Furuta S; Machida T; Takayasu H; Islam A; Nakamura Y; Takahashi M; Shishikura T; Kaneko Y; Toyoda A; Hattori M; Sakaki Y; Ohki M; Horii A; Soeda E; Inazawa J; Seki N; Kuma H; Nozawa I; Sakiyama S
Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma.
Medical and pediatric oncology 2000;35(6):516-21.
2000: Hanaoka E; Ozaki T; Nakamura Y; Moriya H; Nakagawara A; Sakiyama S
Overexpression of DAN causes a growth suppression in p53-deficient SAOS-2 cells.
Biochemical and biophysical research communications 2000;278(1):20-6.
2000: Ozaki T; Nakamura Y; Hanaoka E; Nakagawara A; Sakiyama S
Overexpression of DA41 in v-Ha-ras-3Y1 cells causes growth suppression.
Japanese journal of cancer research : Gann 2000;91(10):987-93.
2000: Ohira M; Kageyama H; Mihara M; Furuta S; Machida T; Shishikura T; Takayasu H; Islam A; Nakamura Y; Takahashi M; Tomioka N; Sakiyama S; Kaneko Y; Toyoda A; Hattori M; Sakaki Y; Ohki M; Horii A; Soeda E; Inazawa J; Seki N; Kuma H; Nozawa I; Nakagawara A
Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line.
Oncogene 2000;19(37):4302-7.
2000: Ozaki T; Nagase T; Ichimiya S; Seki N; Ohiri M; Nomura N; Takada N; Sakiyama S; Weber B L; Nakagawara A
NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain.
DNA and cell biology 2000;19(8):475-85.
2000: Nagai M; Ichimiya S; Ozaki T; Seki N; Mihara M; Furuta S; Ohira M; Tomioka N; Nomura N; Sakiyama S; Kubo O; Takakura K; Hori T; Nakagawara A
Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2.
International journal of oncology 2000;16(5):907-16.
2000: Islam A; Kageyama H; Takada N; Kawamoto T; Takayasu H; Isogai E; Ohira M; Hashizume K; Kobayashi H; Kaneko Y; Nakagawara A
High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma.
Oncogene 2000;19(5):617-23.
2000: Hanaoka E; Ozaki T; Ohira M; Nakamura Y; Suzuki M; Takahashi E; Moriya H; Nakagawara A; Sakiyama S
Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3.
Journal of human genetics 2000;45(3):188-91.
1999: Ozaki T; Naka M; Takada N; Tada M; Sakiyama S; Nakagawara A
Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells.
Cancer research 1999;59(23):5902-7.
1999: Sunahara M; Shishikura T; Takahashi M; Todo S; Yamamoto N; Kimura H; Kato S; Ishioka C; Ikawa S; Ikawa Y; Nakagawara A
Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer.
Oncogene 1999;18(25):3761-5.
1999: Ozaki T; Hanaoka E; Naka M; Nakagawara A; Sakiyama S
Cloning and characterization of rat BAT3 cDNA.
DNA and cell biology 1999;18(6):503-12.
1999: Takada N; Ozaki T; Ichimiya S; Todo S; Nakagawara A
Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas.
Cancer research 1999;59(12):2810-4.
1999: Shishikura T; Ichimiya S; Ozaki T; Nimura Y; Kageyama H; Nakamura Y; Sakiyama S; Miyauchi M; Yamamoto N; Suzuki M; Nakajima N; Nakagawara A
Mutational analysis of the p73 gene in human breast cancers.
International journal of cancer. Journal international du cancer 1999;84(3):321-5.
1999: Ichimiya S; Nimura Y; Kageyama H; Takada N; Sunahara M; Shishikura T; Nakamura Y; Sakiyama S; Seki N; Ohira M; Kaneko Y; McKeon F; Caput D; Nakagawara A
p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent.
Oncogene 1999;18(4):1061-6.
1998: Nimura Y; Mihara M; Ichimiya S; Sakiyama S; Seki N; Ohira M; Nomura N; Fujimori M; Adachi W; Amano J; He M; Ping Y M; Nakagawara A
p73, a gene related to p53, is not mutated in esophageal carcinomas.
International journal of cancer. Journal international du cancer 1998;78(4):437-40.
1998: Nakagawara A
Molecular basis of spontaneous regression of neuroblastoma: role of neurotrophic signals and genetic abnormalities.
Human cell : official journal of Human Cell Research Society 1998;11(3):115-24.
1998: Hiwasa T; Nakagawara A
Suppression of transformed phenotypes of Ha-ras-transformed NIH3T3 cells by caspase-2.
Biochemical and biophysical research communications 1998;250(3):741-6.
1998: Enomoto H; Nakamura Y; Kondo K; Hirose M; Kaneko Y; Horie H; Takahashi H; Ohnuma N; Tanabe M; Nakagawara A
In vivo karyotypic evolution with altered biological characteristics in a case of neuroblastoma.
Journal of pediatric surgery 1998;33(9):1404-7.
1998: Nakagawara A
The NGF story and neuroblastoma.
Medical and pediatric oncology 1998;31(2):113-5.
1998: Sunahara M; Ichimiya S; Nimura Y; Takada N; Sakiyama S; Sato Y; Todo S; Adachi W; Amano J; Nakagawara A
Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.
International journal of oncology 1998;13(2):319-23.
1998: Kimura M; Tagawa M; Takenaga K; Kondo F; Yamaguchi T; Saisho H; Nakagawara A; Sakiyama S
Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interleukin-2 or interleukin-4 in nude mice: a potentiality for cancer gene therapy.
Cancer letters 1998;128(1):47-53.
1998: Hishiki T; Nimura Y; Isogai E; Kondo K; Ichimiya S; Nakamura Y; Ozaki T; Sakiyama S; Hirose M; Seki N; Takahashi H; Ohnuma N; Tanabe M; Nakagawara A
Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2.
Cancer research 1998;58(10):2158-65.
1998: Hiwasa T; Kondo K; Nakagawara A; Ohkoshi M
Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.
Cancer letters 1998;126(2):221-5.
1998: Nakamura Y; Ozaki T; Ichimiya S; Nakagawara A; Sakiyama S
Ectopic expression of DAN enhances the retinoic acid-induced neuronal differentiation in human neuroblastoma cell lines.
Biochemical and biophysical research communications 1998;243(3):722-6.
1998: Kageyama H; Seki N; Yamada S; Sakiyama S; Nakagawara A
DPC4 splice variants in neuroblastoma.
Cancer letters 1998;122(1-2):187-93.
1997: Hiwasa T; Kondo K; Hishiki T; Koshizawa S; Umezawa K; Nakagawara A
GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors.
Neuroscience letters 1997;238(3):115-8.
1997: Ikeda H; Nakamura Y; Hiwasa T; Sakiyama S; Kuida K; Su M S; Nakagawara A
Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2081-3.
1997: Nakagawara A; Nakamura Y; Ikeda H; Hiwasa T; Kuida K; Su M S; Zhao H; Cnaan A; Sakiyama S
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
Cancer research 1997;57(20):4578-84.
1997: Ozaki T; Enomoto H; Nakamura Y; Kondo K; Seki N; Ohira M; Nomura N; Ohki M; Nakagawara A; Sakiyama S
The genomic analysis of human DAN gene.
DNA and cell biology 1997;16(9):1031-9.
1997: Ozaki T; Hishiki T; Toyama Y; Yuasa S; Nakagawara A; Sakiyama S
Identification of a new cellular protein that can interact specifically with DAN.
DNA and cell biology 1997;16(8):985-91.
1997: Ozaki T; Kondo K; Nakamura Y; Ichimiya S; Nakagawara A; Sakiyama S
Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5).
Biochemical and biophysical research communications 1997;237(2):245-50.
1997: Kimura M; Tagawa M; Takenaga K; Yamaguchi T; Saisho H; Nakagawara A; Sakiyama S
Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene.
Anticancer research 1997;17(2A):879-83.

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