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Shizuo Nakajin

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TOP 3
Masatada Watanabe; Shuji Ohno; Shizuo Nakajin
Effects of bisphenol A on the expression of cytochrome P450 aromatase (CYP19) in human fetal osteoblastic and granulosa cell-like cell lines.
Shuji Ohno; Shizuo Nakajin
Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.
Shuji Ohno; Masanori Ohta; Yoko Honda; Shizuo Nakajin
Sequence and expression of 11beta-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis.

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All Publications

2012: Masatada Watanabe; Shuji Ohno; Shizuo Nakajin
Effects of bisphenol A on the expression of cytochrome P450 aromatase (CYP19) in human fetal osteoblastic and granulosa cell-like cell lines.
Toxicology letters 2012;210(1):95-9.
2011: Shuji Ohno; Shizuo Nakajin
Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.
Drug metabolism letters 2011;5(3):202-8.
2010: Shuji Ohno; Masanori Ohta; Yoko Honda; Shizuo Nakajin
Sequence and expression of 11beta-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis.
Molecular and cellular biochemistry 2010;338(1-2):149-56.
2009: Shuji Ohno; Fumihiko Yukinawa; Mariko Noda; Shizuo Nakajin
Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN.
Toxicology letters 2009;191(2-3):353-9.
2008: Shuji Ohno; Kiyoshi Kawana; Shizuo Nakajin
Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(4):688-94.
2008: Shuji Ohno; Kouki Nishikawa; Yoko Honda; Shizuo Nakajin
Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8.
Molecular and cellular biochemistry 2008;309(1-2):209-15.
2008: Y Honda; Shuji Ohno; Shizuo Nakajin
Leydig cells from neonatal pig testis abundantly express 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2 and effectively inactivate cortisol to cortisone.
The Journal of steroid biochemistry and molecular biology 2008;108(1-2):91-101.
2007: Masatada Watanabe; Mariko Noda; Shizuo Nakajin
Aromatase expression in a human osteoblastic cell line increases in response to prostaglandin E(2) in a dexamethasone-dependent fashion.
Steroids 2007;72(9-10):686-92.
2007: Mariko Noda; Shuji Ohno; Shizuo Nakajin
Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP.
Molecular and cellular endocrinology 2007;274(1-2):8-18.
2006: Shuji Ohno; Yoko Honda; Yonako Nakajima; Shizuo Nakajin
Sequence of pig 17beta-hydroxysteroid dehydrogenase Type3 cDNA and its expression in mammalian cells.
The Journal of steroid biochemistry and molecular biology 2006;101(2-3):145-50.
2006: Masatada Watanabe; Mariko Noda; Shizuo Nakajin
Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.
The Journal of endocrinology 2006;188(1):59-68.
2005: Shuji Ohno; Yonako Nakajima; Shizuo Nakajin
Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis.
Steroids 2005;70(9):645-51.
2005: Yonako Nakajima; Shuji Ohno; Go Sato; Shizuo Nakajin
Tributyltin chloride suppresses the P450cl7 transcription involved in testosterone production induced by gonadotropin stimulation in cultured pig Leydig cells.
Environmental toxicology and pharmacology 2005;20(1):11-7.
2005: Masatada Watanabe; Shuji Ohno; Shizuo Nakajin
Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(4):619-24.
2005: Masayoshi Ohshima; Shuji Ohno; Shizuo Nakajin
Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands.
Environmental sciences : an international journal of environmental physiology and toxicology 2005;12(4):219-30.
2004: Takuya Sugiyama; Shuji Ohno; Debashis Ghosh; Shizuo Nakajin
3alpha/beta,20beta-hydroxysteroid dehydrogenase (porcine testicular carbonyl reductase) also has a cysteine residue that is involved in binding of cofactor NADPH.
The Journal of steroid biochemistry and molecular biology 2004;88(4-5):393-8.
2004: Shuji Ohno; Noriko Matsumoto; Masatada Watanabe; Shizuo Nakajin
Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II.
The Journal of steroid biochemistry and molecular biology 2004;88(2):175-82.
2004: Masatada Watanabe; Shizuo Nakajin
Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R.
The Journal of endocrinology 2004;180(1):125-33.
2003: Shuji Ohno; Yonako Nakajima; Koichi Inoue; Hiroyuki Nakazawa; Shizuo Nakajin
Genistein administration decreases serum corticosterone and testosterone levels in rats.
Life sciences 2003;74(6):733-42.
2003: Teruaki Oku; Saotomo Itoh; Masamitsu Okano; Akiko Suzuki; Kensuke Suzuki; Shizuo Nakajin; Tsutomu Tsuji; William M Nauseef; Satoshi Toyoshima
Two regions responsible for the actin binding of p57, a mammalian coronin family actin-binding protein.
Biological & pharmaceutical bulletin 2003;26(4):409-16.
2002: Masaya Itoda; Noriko Takase; Shizuo Nakajin
Inhibition of 3 alpha/beta,20 beta-hydroxysteroid dehydrogenase by dexamethasone, glycyrrhetinic acid and spironolactone is attenuated by deletion of 12 carboxyl-terminal residues.
Biological & pharmaceutical bulletin 2002;25(9):1220-2.
2002: Saotomo Itoh; Kensuke Suzuki; Jun Nishihata; Mitsusada Iwasa; Teruaki Oku; Shizuo Nakajin; William M Nauseef; Satoshi Toyoshima
The role of protein kinase C in the transient association of p57, a coronin family actin-binding protein, with phagosomes.
Biological & pharmaceutical bulletin 2002;25(7):837-44.
2002: Jun-Ichi Kashiwakura; Noboru Suzuki; Mitsuhiro Takeno; Saotomo Itoh; Teruaki Oku; Tsuyoshi Sakane; Shizuo Nakajin; Satoshi Toyoshima
Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.
Biological & pharmaceutical bulletin 2002;25(6):718-21.
2002: Minoru Tanaka; Shizuo Nakajin; Daisuke Kobayashi; Sachiko Fukada; Guijun Guan; Takashi Todo; Balasubramanian Senthilkumaran; Yoshitaka Nagahama
Teleost ovarian carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase: potential role in the production of maturation-inducing hormone during final oocyte maturation.
Biology of reproduction 2002;66(5):1498-504.
2002: Shuji Ohno; Satoshi Shinoda; Satoshi Toyoshima; Hiroyuki Nakazawa; Tsunehisa Makino; Shizuo Nakajin
Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells.
The Journal of steroid biochemistry and molecular biology 2002;80(3):355-63.
2001: Shizuo Nakajin; Masaya Itoda; Shuji Ohno; Noriko Takase; Satoshi Toyoshima; Michael E Baker
Deletion of 12 carboxyl-terminal residues from pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase affects steroid metabolism.
Biochimica et biophysica acta 2001;1550(2):175-82.
2001: Shizuo Nakajin; Hiroyuki Nakazawa; Shuji Ohno; S Shinoda; T Makino
Effect of phthalate esters and alkylphenols on steroidogenesis in human adrenocortical H295R cells.
Environmental toxicology and pharmacology 2001;10(3):103-10.
2000: Sciotti Michel Angelo; Shizuo Nakajin; Bendicht Wermuth; Michael E Baker
Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase.
The Biochemical journal 2000;350 Pt 1():89-92.
1998: Shizuo Nakajin; N Minamikawa; Michael E Baker; Satoshi Toyoshima
An NADPH-dependent reductase in neonatal pig testes that metabolizes androgens and xenobiotics.
Biological & pharmaceutical bulletin 1998;21(12):1356-60.
1998: Shizuo Nakajin; Noriko Takase; Shuji Ohno; Satoshi Toyoshima; Michael E Baker
Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase.
The Biochemical journal 1998;334 ( Pt 3)():553-7.
1997: Shizuo Nakajin; F Tamura; Noriko Takase; Satoshi Toyoshima
Carbonyl reductase activity exhibited by pig testicular 20 beta-hydroxysteroid dehydrogenase.
Biological & pharmaceutical bulletin 1997;20(11):1215-8.
1996: K Kobayashi; S Ohno; M Shinoda; Satoshi Toyoshima; Shizuo Nakajin
Immunochemical distribution and immunohistochemical localization of 20beta-hydroxysteroid dehydrogenase in neonatal pig tissues.
The Journal of steroid biochemistry and molecular biology 1996;59(5-6):485-93.
1996: M Uchida; Shizuo Nakajin; Satoshi Toyoshima; M Shinoda
Antioxidative effect of sesamol and related compounds on lipid peroxidation.
Biological & pharmaceutical bulletin 1996;19(4):623-26.
1995: Shizuo Nakajin; T Nakajima; M Uchida; S Ohno; M Shinoda
Direct expression of pig testicular 3 alpha/beta (20 beta)-hydroxysteroid dehydrogenase in Escherichia coli.
The Journal of steroid biochemistry and molecular biology 1995;54(5-6):257-64.
1995: Shizuo Nakajin; T Nakajima; M Uchida; M Shinoda
[Direct expression of the pig testicular 3 alpha/beta(20 beta)- hydroxysteroid dehydrogenase cDNA using baculovirus expression system].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(4):344-50.
1994: Shizuo Nakajin; A Ishii; M Shinoda
Purification and characterization of 5 alpha-dihydrotestosterone 3 beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol.
Biological & pharmaceutical bulletin 1994;17(9):1155-60.
1994: Shizuo Nakajin; Y Fujita; S Ohno; M Uchida; M Aoki; M Shinoda
Purification and characterization of 3 alpha/beta-hydroxysteroid dehydrogenase from mature porcine testicular cytosol.
The Journal of steroid biochemistry and molecular biology 1994;48(2-3):249-56.
1993: Shizuo Nakajin; H Shin; M Shinoda
[Purification of pig adrenal 3 beta-hydroxysteroid dehydrogenase/isomerase and influence on microsomal membrane destruction on its enzyme activity].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1993;113(3):243-55.
1992: S Ohno; Shizuo Nakajin; M Shinoda
Ontogeny of testicular steroid dehydrogenase enzymes in pig (3 alpha/beta-, 20 alpha- and 20 beta-): evidence for two forms of 3 alpha/beta-hydroxysteroid dehydrogenase.
The Journal of steroid biochemistry and molecular biology 1992;42(1):17-21.
1992: Shizuo Nakajin; S Fujii; S Ohno; M Shinoda
3 alpha-hydroxysteroid dehydrogenase activity catalyzed by purified pig adrenal 20 alpha-hydroxysteroid dehydrogenase.
The Journal of steroid biochemistry and molecular biology 1992;41(2):179-84.
1991: Shizuo Nakajin; S Fujii; S Ohno; M Shinoda
[Purification and some properties of 3 alpha-hydroxysteroid dehydrogenase from pig adrenal cytosol].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1991;111(12):775-82.
1991: S Ohno; Shizuo Nakajin; M Shinoda
20 beta-hydroxysteroid dehydrogenase of neonatal pig testis: 3 alpha/beta-hydroxysteroid dehydrogenase activities catalyzed by highly purified enzyme.
The Journal of steroid biochemistry and molecular biology 1991;38(6):787-94.
1991: S Ohno; Shizuo Nakajin; M Shinoda
20 beta-hydroxysteroid dehydrogenase of neonatal pig testis: reverse catalytic (oxidation) reaction.
Chemical & pharmaceutical bulletin 1991;39(4):972-5.
1991: Shizuo Nakajin; K Takahashi; M Shinoda
Inhibitory effect of some imidazole antifungal compounds on the synthesis of 16-ene-C19-steroid catalyzed by pig testicular microsomes.
The Journal of steroid biochemistry and molecular biology 1991;38(1):95-9.
1989: Shizuo Nakajin; Y Kawai; S Ohno; M Shinoda
Purification and characterization of pig adrenal 20 alpha-hydroxysteroid dehydrogenase.
Journal of steroid biochemistry 1989;33(6):1181-9.
1988: Shizuo Nakajin; S Ohno; M Shinoda
20 beta-hydroxysteroid dehydrogenase of neonatal pig testis: purification and some properties.
Journal of biochemistry 1988;104(4):565-9.