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Graeme Bell

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Chemicals & Drugs

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Type 2 Diabetes Mellitus

Genes & Molecular Sequences

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Publications

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D Savic; S Y Park; K A Bailey; Graeme I Bell; Marcelo A Nobrega
In vitro scan for enhancers at the TCF7L2 locus.
Anita S Chong; Graeme I Bell
Three Strikes and You're Cured.
Stefan Johansson; Inge Jonassen; Per M Knappskog; Shawn Levy; Kari Lima; Janne Molnes; Anders Molven; Jan Aerts; Graeme I Bell; Kishan K Chudasama; Henrik Irgens; Francisco S Roque; Pål R Njølstad
Exome sequencing and genetic testing for MODY.

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All Publications

2013: D Savic; S Y Park; K A Bailey; Graeme I Bell; Marcelo A Nobrega
In vitro scan for enhancers at the TCF7L2 locus.
Diabetologia 2013;56(1):121-5.
2012: Anita S Chong; Graeme I Bell
Three Strikes and You're Cured.
Science translational medicine 2012;4(133):133fs12.
2012: Stefan Johansson; Inge Jonassen; Per M Knappskog; Shawn Levy; Kari Lima; Janne Molnes; Anders Molven; Jan Aerts; Graeme I Bell; Kishan K Chudasama; Henrik Irgens; Francisco S Roque; Pål R Njølstad
Exome sequencing and genetic testing for MODY.
PloS one 2012;7(5):e38050.
2012: Daniel Savic; Graeme I Bell; Marcelo A Nobrega
An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.
PloS one 2012;7(5):e36501.
2011: Siri Atma W Greeley; Rochelle N Naylor; Louis H Philipson; Graeme I Bell
Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.
Current diabetes reports 2011;11(6):519-32.
2011: Daniel Savic; Honggang Ye; Ivy Aneas; Graeme I Bell; Soo-Young Park; Marcelo A Nobrega
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.
Genome research 2011;21(9):1417-25.
2011: Jennifer Below; Nancy J Cox; Miguel Cruz; S C Elbein; Eric Gamazon; D M Hallman; A Konkashbaev; Paul M McKeigue; J V Morrison; Dan L Nicolae; Esteban J Parra; Anna Pluzhnikov; Graeme I Bell; Craig L Hanis
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
Diabetologia 2011;54(8):2047-55.
2010: Siri Atma W Greeley; Susan E Tucker; Rochelle N Naylor; Graeme I Bell; Louis H Philipson
Neonatal diabetes mellitus: a model for personalized medicine.
Trends in endocrinology and metabolism: TEM 2010;21(8):464-72.
2010: Sindhu Rajan; Stefani C Eames; Soo-Young Park; Christine Labno; Graeme I Bell; Victoria E Prince; Louis H Philipson
In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E403-10.
2010: Siri Atma W Greeley; Susan E Tucker; Helen I Worrell; Kinga B Skowron; Graeme I Bell; Louis H Philipson
Update in neonatal diabetes.
Current opinion in endocrinology, diabetes, and obesity 2010;17(1):13-9.
2010: Soo-Young Park; Honggang Ye; Donald F Steiner; Graeme I Bell
Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
Biochemical and biophysical research communications 2010;391(3):1449-54.
2010: Yi-Ping Fu; D Michael Hallman; Victor H Gonzalez; Barbara E K Klein; Ronald Klein; M Geoffrey Hayes; Nancy J Cox; Graeme I Bell; Craig L Hanis
Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas.
Journal of ophthalmology 2010;2010():.
2010: Eric J Grossman; David D Lee; Jing Tao; Raphael A Wilson; Soo-Young Park; Graeme I Bell; Anita S Chong
Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice.
PloS one 2010;5(1):e8749.
2009: Toshihide Kawai; Maggie C Y Ng; M Geoffrey Hayes; Issei Yoshiuchi; Takafumi Tsuchiya; Heather Robertson; Nancy J Cox; Kenneth S Polonsky; Graeme I Bell; David A Ehrmann
Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Diabetes research and clinical practice 2009;86(3):186-92.
2009: Donald F Steiner; S-Y Park; J Støy; Louis H Philipson; Graeme I Bell
A brief perspective on insulin production.
Diabetes, obesity & metabolism 2009;11 Suppl 4():189-96.
2009: S-Y Park; Graeme I Bell
Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in MIP-luc transgenic mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2009;41(1):1-4.
2008: Julie Støy; Siri Atma W Greeley; Veronica P Paz; Honggang Ye; Ashley N Pastore; Kinga B Skowron; Rebecca B Lipton; Fran R Cogen; Graeme I Bell; Louis H Philipson
Diagnosis and treatment of neonatal diabetes: a United States experience.
Pediatric diabetes 2008;9(5):450-9.
2008: Anders Molven; Monika Ringdal; Anita M Nordbø; Helge Raeder; Julie Støy; Gregory M Lipkind; Donald F Steiner; Louis H Philipson; Ines Bergmann; Dagfinn Aarskog; DAG UNDLIEN; Geir Joner; Oddmund Søvik; Graeme I Bell; Pål R Njølstad
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
Diabetes 2008;57(4):1131-5.
2008: Emma L Edghill; Sarah Flanagan; Ann-Marie Patch; Chris Boustred; Andrew Parrish; Beverley Shields; Maggie H Shepherd; Khalid Hussain; Ritika R Kapoor; Maciej Malecki; Michael J MacDonald; Julie Støy; Donald F Steiner; Louis H Philipson; Graeme I Bell; Andrew T Hattersley; Sian Ellard
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
Diabetes 2008;57(4):1034-42.
2007: M Geoffrey Hayes; Anna Pluzhnikov; Kazuaki Miyake; Ying Sun; Maggie C Y Ng; Cheryl Roe; Jennifer Below; Raluca Nicolae; Anuar Konkashbaev; Graeme I Bell; Nancy J Cox; Craig L Hanis
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.
Diabetes 2007;56(12):3033-44.
2007: M Hara; J Shen; William Pugh; Kenneth S Polonsky; M M Le Beau; Graeme I Bell
Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(10):654-61.
2007: Julie Støy; Emma L Edghill; Sarah Flanagan; Honggang Ye; Veronica P Paz; Anna Pluzhnikov; Jennifer Below; M Geoffrey Hayes; Nancy J Cox; Gregory M Lipkind; Rebecca B Lipton; Siri Atma W Greeley; Ann-Marie Patch; Sian Ellard; Donald F Steiner; Andrew T Hattersley; Louis H Philipson; Graeme I Bell
Insulin gene mutations as a cause of permanent neonatal diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15040-4.
2006: Eba H Hathout; John W Mace; Graeme I Bell; Pål R Njølstad
Treatment of hyperglycemia in a 7-year-old child diagnosed with neonatal diabetes.
Diabetes care 2006;29(6):1458.
2006: Jørn V Sagen; Stella Odili; Lise Bjørkhaug; Dorothy Zelent; Carol Buettger; Jae Kwagh; Charles Stanley; Knut Dahl-Jørgensen; Carine de Beaufort; Graeme I Bell; Yi Han; Joseph Grimsby; Rebecca Taub; Anders Molven; Oddmund Søvik; Pål R Njølstad; Franz M Matschinsky
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
Diabetes 2006;55(6):1713-22.
2005: M Geoffrey Hayes; Laura Del Bosque-Plata; Takafumi Tsuchiya; Craig L Hanis; Graeme I Bell; Nancy J Cox
Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10.
Diabetes 2005;54(12):3573-6.
2005: Maggie C Y Ng; K Miyake; Wing-Yee So; E W M Poon; Vincent K L Lam; J K Y Li; Nancy J Cox; Graeme I Bell; J C N Chan
The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population.
Diabetologia 2005;48(10):2018-24.
2005: Soo-Young Park; Xiaoyu Wang; Zhongyi Chen; Alvin C Powers; Mark Magnuson; W Steven Head; David W Piston; Graeme I Bell
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
Genesis (New York, N.Y. : 2000) 2005;43(2):80-6.
2005: Helmut Grasberger; Graeme I Bell
Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.
The international journal of biochemistry & cell biology 2005;37(7):1421-37.
2005: Jing-Tian Xie; Sangeeta R Mehendale; Xinmin Li; Richard J Quigg; Xiaoyu Wang; Chong-Zhi Wang; Ji An Wu; Han H Aung; Paul A Rue; Graeme I Bell; Chun-Su Yuan
Anti-diabetic effect of ginsenoside Re in ob/ob mice.
Biochimica et biophysica acta 2005;1740(3):319-25.
2005: Chang-Zheng Wang; Yong Wang; Anke Di; Mark Magnuson; Honggang Ye; Michael W Roe; Deborah J Nelson; Graeme I Bell; Louis H Philipson
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Biochemical and biophysical research communications 2005;330(4):1073-9.
2005: Brian Cockburn; Giovanna Bermano; L L Boodram; Surujpal Teelucksingh; T Tsuchiya; D Mahabir; A B Allan; R Stein; Kevin Docherty; Graeme I Bell
Gene symbol: IPF1. Disease: MODY 4.
Human genetics 2005;116(6):538.
2005: Helmut Grasberger; Honggang Ye; Hirosato Mashima; Graeme I Bell
Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1.
Gene 2005;344():143-59.
2005: Subhadra C Gunawardana; Manami Hara; Graeme I Bell; W Steven Head; Mark Magnuson; David W Piston
Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.
In vitro cellular & developmental biology. Animal 2005;41(1-2):7-11.
2005: Naoko Iwasaki; Yukio Horikawa; Takafumi Tsuchiya; Yutaka Kitamura; Takahiro Nakamura; Yukio Tanizawa; Yoshitomo Oka; Kazuo Hara; Takashi Kadowaki; Takuya Awata; Masashi Honda; Katsuko Yamashita; Naohisa Oda; Li Yu; Norihiro Yamada; Makiko Ogata; Naoyuki Kamatani; Yasuhiko Iwamoto; Laura Del Bosque-Plata; M Geoffrey Hayes; Nancy J Cox; Graeme I Bell
Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population.
Journal of human genetics 2005;50(2):92-8.
2004: Jørn V Sagen; Helge Raeder; Eba H Hathout; Naim Shehadeh; Kolbeinn Gudmundsson; Halvor Baevre; Dianne Abuelo; Chanika Phornphutkul; Janne Molnes; Graeme I Bell; Anna L Gloyn; Andrew T Hattersley; Anders Molven; Oddmund Søvik; Pål R Njølstad
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
Diabetes 2004;53(10):2713-8.
2004: Maggie C Y Ng; Wing-Yee So; Vincent K L Lam; Clive S Cockram; Graeme I Bell; Nancy J Cox; Juliana C N Chan
Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.
Diabetes 2004;53(10):2676-83.
2004: Sergio Y Alcoser; Manami Hara; Graeme I Bell; David A Ehrmann
Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2004;89(6):2973-6.
2004: Maggie C Y Ng; Wing-Yee So; Nancy J Cox; Vincent K L Lam; Clive S Cockram; Julian A J H Critchley; Graeme I Bell; Juliana C N Chan
Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.
Diabetes 2004;53(6):1609-13.
2004: Brian Cockburn; Giovanna Bermano; Laura-Lee G Boodram; Surujpal Teelucksingh; Takafumi Tsuchiya; Deepak Mahabir; Andrew B Allan; Roland Stein; Kevin Docherty; Graeme I Bell
Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.
The Journal of clinical endocrinology and metabolism 2004;89(2):971-8.
2004: Nancy J Cox; M Geoffrey Hayes; Cheryl Roe; Takafumi Tsuchiya; Graeme I Bell
Linkage of calpain 10 to type 2 diabetes: the biological rationale.
Diabetes 2004;53 Suppl 1():S19-25.
2004: Laura Del Bosque-Plata; Carlos Aguilar Salinas; María Teresa Tusié-Luna; Salvador Ramírez-Jiménez; Maribel Rodríguez-Torres; Moisés Aurón-Gómez; Erika Ramírez; María Luisa Velasco-Pérez; Alfredo Ramírez-Silva; Francisco J Gómez Pérez; Craig L Hanis; Takafumi Tsuchiya; Issei Yoshiuchi; Nancy J Cox; Graeme I Bell
Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.
Molecular genetics and metabolism 2004;81(2):122-6.
2003: Wing-Yee So; Maggie C Y Ng; Yukio Horikawa; Pal R Njølstad; June K Y Li; Ronald Ma; Graeme I Bell; Juliana C N Chan
Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.
Journal of diabetes and its complications 2003;17(6):369-73.
2003: Michael Weedon; P E H Schwarz; Yukio Horikawa; Naoko Iwasaki; Thomas Illig; Rolf Holle; Wolfgang Rathmann; Thomas Selisko; Jan Schulze; Katharine R Owen; Julie Evans; Laura Del Bosque-Plata; Graham A Hitman; Mark Walker; Jonathan C Levy; Mike Sampson; Graeme I Bell; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
American journal of human genetics 2003;73(5):1208-12.
2003: Rossi P Naoumova; Stephanie A Bonney; Sophie Eichenbaum-Voline; Hetal N Patel; Bethan Jones; Emma L Jones; Joanna Amey; Susan Colilla; Clare Neuwirth; Rebecca Allotey; Mary Seed; D John Betteridge; David J Galton; Nancy J Cox; Graeme I Bell; James Scott; Carol C Shoulders
Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2070-7.
2003: Yun-Ping Zhou; Seamus Sreenan; Chien-Yuan Pan; Kevin P M Currie; Vytautas P Bindokas; Yukio Horikawa; Jean-Pyo Lee; Diane Ostrega; Noreen Ahmed; Aaron C Baldwin; Nancy J Cox; Aaron P Fox; Richard J Miller; Graeme I Bell; Kenneth S Polonsky
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
Metabolism: clinical and experimental 2003;52(5):528-34.
2003: Samuel Canizales-Quinteros; Carlos Aguilar Salinas; Eduardo Reyes-Rodríguez; Laura Riba; Maribel Rodríguez-Torres; Salvador Ramírez-Jiménez; Adriana Huertas-Vázquez; Verónica Fragoso-Ontiveros; Alejandro Zentella-Dehesa; José Luis Ventura-Gallegos; Gerardo Vega-Hernández; Angelina López-Estrada; Moisés Aurón-Gómez; Francisco J Gómez Pérez; Juan A Rull; Nancy J Cox; Graeme I Bell; María Teresa Tusié-Luna
Locus on chromosome 6p linked to elevated HDL cholesterol serum levels and to protection against premature atherosclerosis in a kindred with familial hypercholesterolemia.
Circulation research 2003;92(5):569-76.
2003: Naoko Iwasaki; Nancy J Cox; Yan-Qing Wang; P E H Schwarz; Graeme I Bell; Masashi Honda; Mitsuo Imura; Makiko Ogata; Masayuki Saito; Naoyuki Kamatani; Yasuhiko Iwamoto
Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.
Diabetes 2003;52(1):209-13.
2003: Manami Hara; Xiaoyu Wang; Toshihiko Kawamura; Vytautas P Bindokas; Restituto F Dizon; Sergio Y Alcoser; Mark Magnuson; Graeme I Bell
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
American journal of physiology. Endocrinology and metabolism 2003;284(1):E177-83.
2002: Søren K Rasmussen; Søren A Urhammer; Lars Berglund; Jan N Jensen; Lars Hansen; Søren M Echwald; Knut Borch-Johnsen; Yukio Horikawa; Hirosato Mashima; Hans Lithell; Nancy J Cox; Torben Hansen; Graeme I Bell; Oluf Pedersen
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Diabetes 2002;51(12):3561-7.
2002: David A Ehrmann; Xu Tang; Issei Yoshiuchi; Nancy J Cox; Graeme I Bell
Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(9):4297-300.
2002: Lema Haddad; Julie C Evans; Neda Gharani; Carole Robertson; Karen Rush; Steven Wiltshire; Timothy M Frayling; Terence J Wilkin; Andrew G Demaine; Ann Millward; Andrew T Hattersley; Gerry Conway; Nancy J Cox; Graeme I Bell; Stephen Franks; Mark I McCarthy
Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(6):2606-10.
2002: Stephanie M Fullerton; Angelika Bartoszewicz; Gustavo Ybazeta; Yukio Horikawa; Graeme I Bell; Kenneth K Kidd; Nancy J Cox; Richard R Hudson; Anna Di Rienzo
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
American journal of human genetics 2002;70(5):1096-106.
2002: David A Ehrmann; P E H Schwarz; Manami Hara; Xu Tang; Yukio Horikawa; Jacqueline Imperial; Graeme I Bell; Nancy J Cox
Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(4):1669-73.
2002: Makiko Ogata; Takeo Awaji; Naoko Iwasaki; Shunichi Miyazaki; Graeme I Bell; Yasuhiko Iwamoto
Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells.
Biochemical and biophysical research communications 2002;292(1):8-12.
2002: Sean M Forsythe; Paul Kogut; John McConville; Yiping Fu; Joel A McCauley; Andrew J Halayko; Hong Wei Liu; Allen Kao; Darren J Fernandes; Shashi Bellam; Elaine Fuchs; Satrajit Sinha; Graeme I Bell; Blanca Camoretti-Mercado; Julian Solway
Structure and transcription of the human m3 muscarinic receptor gene.
American journal of respiratory cell and molecular biology 2002;26(3):298-305.
2001: Seamus Sreenan; Yun-Ping Zhou; K Otani; Polly A Hansen; Kevin P M Currie; Chien-Yuan Pan; Jean-Pyo Lee; Diane Ostrega; William Pugh; Yukio Horikawa; Nancy J Cox; Craig L Hanis; Charles F Burant; Aaron P Fox; Graeme I Bell; Kenneth S Polonsky
Calpains play a role in insulin secretion and action.
Diabetes 2001;50(9):2013-20.
2001: Julie C Evans; Timothy M Frayling; Paul G Cassell; PJ Saker; Graham A Hitman; Mark Walker; Jonathan C Levy; Stephen O'Rahilly; PV Rao; A J Bennett; E C Jones; Stephan Menzel; P Prestwich; N Simecek; Marie Wishart; R Dhillon; C Fletcher; Ann Millward; Andrew G Demaine; T Wilkin; Y Horikawa; N J Cox; Graeme I Bell; Sian Ellard; Mark I McCarthy; Andrew T Hattersley
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
American journal of human genetics 2001;69(3):544-52.
2001: Pål R Njølstad; Oddmund Søvik; A Cuesta-Muñoz; Lise Bjørkhaug; Ornella Massa; Fabrizio Barbetti; DAG UNDLIEN; Chiyo Shiota; Mark Magnuson; Anders Molven; Franz M Matschinsky; Graeme I Bell
Neonatal diabetes mellitus due to complete glucokinase deficiency.
The New England journal of medicine 2001;344(21):1588-92.
2001: Laura Del Bosque-Plata; J Lin; Yukio Horikawa; P E H Schwarz; Nancy J Cox; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; Michael S German; Graeme I Bell
Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
Diabetes 2001;50(3):694-6.
2001: Manami Hara; X Wang; Veronica P Paz; Naoko Iwasaki; M Honda; Yasuhiko Iwamoto; Graeme I Bell
Identification of three missense mutations in the peroxisome proliferator-activated receptor alpha gene in Japanese subjects with maturity-onset diabetes of the young.
Journal of human genetics 2001;46(5):285-8.
2000: Yukio Horikawa; Y Horikawa; Nancy J Cox; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; VM Schwitzgebel; Michael S German; Graeme I Bell
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Diabetes 2000;49(11):1955-7.
2000: Yukio Horikawa; Naohisa Oda; Nancy J Cox; X Li; M Orho-Melander; Manami Hara; Y Hinokio; TH Lindner; H Mashima; P E H Schwarz; Laura Del Bosque-Plata; Y Horikawa; Y Oda; Issei Yoshiuchi; Susan Colilla; Kenneth S Polonsky; S Wei; Patrick Concannon; Naoko Iwasaki; Jan Schulze; Leslie J Baier; Clifton Bogardus; L Groop; E Boerwinkle; Craig L Hanis; Graeme I Bell
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Nature genetics 2000;26(2):163-75.
2000: Manami Hara; X Wang; Veronica P Paz; Nancy J Cox; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; Graeme I Bell
No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY.
Diabetologia 2000;43(8):1064-9.
2000: Lise Bjørkhaug; Oddmund Søvik; Graeme I Bell; Pål R Njølstad; Anders Molven
A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene.
Diabetologia 2000;43(6):818-9.
2000: Coralie Bingham; Sian Ellard; L Allen; Michael P Bulman; Maggie Shepherd; Timothy M Frayling; P J Berry; Penny M Clark; T Lindner; Graeme I Bell; Gerhart U Ryffel; Anthony J Nicholls; Andrew T Hattersley
Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.
Kidney international 2000;57(3):898-907.
2000: Y Hinokio; Yukio Horikawa; H Furuta; Nancy J Cox; Naoko Iwasaki; M Honda; Makiko Ogata; Yasuhiko Iwamoto; Graeme I Bell
Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young.
Diabetes 2000;49(2):302-5.
1999: Maggie C Y Ng; Brian Cockburn; TH Lindner; V T F Yeung; Chun Chung Chow; Wing-Yee So; June K Y Li; Y M Lo; Zoe S K Lee; Clive S Cockram; Julian A J H Critchley; Graeme I Bell; Juliana C N Chan
Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(11):956-63.
1999: TH Lindner; P R Njolstad; Yukio Horikawa; L Bostad; Graeme I Bell; O Sovik
A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta.
Human molecular genetics 1999;8(11):2001-8.
1999: M Rouard; J Bass; FLORIN GRIGORESCU; T P Garrett; Colin W Ward; Gregory M Lipkind; C Jaffiole; Donald F Steiner; Graeme I Bell
Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain.
The Journal of biological chemistry 1999;274(26):18487-91.
1999: Eba H Hathout; Brian Cockburn; John W Mace; J Sharkey; J Chen-Daniel; Graeme I Bell
A case of hepatocyte nuclear factor-1 alpha diabetes/MODY3 masquerading as type 1 diabetes in a Mexican-American adolescent and responsive to a low dose of sulfonylurea.
Diabetes care 1999;22(5):867-8.
1999: Nancy J Cox; Michael L Frigge; Dan L Nicolae; Patrick Concannon; Craig L Hanis; Graeme I Bell; Augustine Kong
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.
Nature genetics 1999;21(2):213-5.
1999: T H Lindner; Brian Cockburn; Graeme I Bell
Molecular genetics of MODY in Germany.
Diabetologia 1999;42(1):121-3.
1998: Seamus Sreenan; Brian Cockburn; Aaron C Baldwin; Diane Ostrega; Matteo G Levisetti; A Grupe; Graeme I Bell; T A Stewart; Michael W Roe; Kenneth S Polonsky
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
Diabetes 1998;47(12):1881-8.
1998: I D Dukes; Seamus Sreenan; Michael W Roe; Matteo G Levisetti; Yun-Ping Zhou; Diane Ostrega; Graeme I Bell; Marco Pontoglio; Moshe Yaniv; Louis H Philipson; Kenneth S Polonsky
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
The Journal of biological chemistry 1998;273(38):24457-64.
1998: Pål R Njølstad; Brian Cockburn; Graeme I Bell; Oddmund Søvik
A missense mutation, Val62Ala, in the glucokinase gene in a Norwegian family with maturity-onset diabetes of the young.
Acta paediatrica (Oslo, Norway : 1992) 1998;87(8):853-6.
1998: H Furuta; Yukio Horikawa; Naoko Iwasaki; Manami Hara; L Sussel; Michelle M Le Beau; Elizabeth M Davis; Makiko Ogata; Yasuhiko Iwamoto; Michael S German; Graeme I Bell
Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.
Diabetes 1998;47(8):1356-8.
1998: F Beards; Timothy M Frayling; Michael P Bulman; Y Horikawa; L Allen; M Appleton; Graeme I Bell; Sian Ellard; Andrew T Hattersley
Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.
Diabetes 1998;47(7):1152-4.
1998: Marco Pontoglio; Seamus Sreenan; M Roe; William Pugh; Diane Ostrega; Antonia Doyen; AJ Pick; A Baldwin; G Velho; philippe froguel; Matteo G Levisetti; S Bonner-Weir; Graeme I Bell; Moshe Yaniv; Kenneth S Polonsky
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
The Journal of clinical investigation 1998;101(10):2215-22.
1998: Oddmund Søvik; Pål R Njølstad; Ivar Følling; Jørn V Sagen; Brian Cockburn; Graeme I Bell
Hyperexcitability to sulphonylurea in MODY3.
Diabetologia 1998;41(5):607-8.
1998: Manami Hara; TH Lindner; Veronica P Paz; X Wang; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; Graeme I Bell
Mutations in the coding region of the insulin promoter factor 1 gene are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
Diabetes 1998;47(5):845-6.
1998: Pål R Njølstad; Oddmund Søvik; Graeme I Bell; Brian Cockburn; Ivar Følling; Jørn V Sagen
[Non-insulin dependent diabetes in children and adolescents].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1998;118(7):1054-7.
1997: Yukio Horikawa; Naoko Iwasaki; Manami Hara; H Furuta; Y Hinokio; Brian Cockburn; TH Lindner; K Yamagata; Makiko Ogata; Osamu Tomonaga; H Kuroki; T Kasahara; Yasuhiko Iwamoto; Graeme I Bell
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.
Nature genetics 1997;17(4):384-5.
1997: H Furuta; Naoko Iwasaki; Naohisa Oda; Y Hinokio; Yukio Horikawa; K Yamagata; N Yano; J Sugahiro; Makiko Ogata; H Ohgawara; Yasue Omori; Yasuhiko Iwamoto; Graeme I Bell
Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY.
Diabetes 1997;46(10):1652-7.
1997: Claudia Gragnoli; TH Lindner; Brian Cockburn; Pamela J Kaisaki; F Gragnoli; G Marozzi; Graeme I Bell
Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene.
Diabetes 1997;46(10):1648-51.
1997: TH Lindner; Claudia Gragnoli; H Furuta; Brian Cockburn; C Petzold; H Rietzsch; U Weiss; Jan Schulze; Graeme I Bell
Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
The Journal of clinical investigation 1997;100(6):1400-5.
1997: Edward K Chien; Y Tokuyama; M Rouard; Mark Phillippe; Graeme I Bell
Identification of gestationally regulated genes in rat myometrium by use of messenger ribonucleic acid differential display.
American journal of obstetrics and gynecology 1997;177(3):645-52.
1997: Naoko Iwasaki; Naohisa Oda; Makiko Ogata; Manami Hara; Y Hinokio; Y Oda; K Yamagata; S Kanematsu; H Ohgawara; Yasue Omori; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM.
Diabetes 1997;46(9):1504-8.
1997: Brian Cockburn; Diane Ostrega; Jeppe Sturis; C Kubstrup; Kenneth S Polonsky; Graeme I Bell
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Diabetes 1997;46(9):1434-9.
1997: Edward K Chien; M Hara; M Rouard; H Yano; Mark Phillippe; Kenneth S Polonsky; Graeme I Bell
Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats.
Biochemical and biophysical research communications 1997;237(2):476-80.
1997: TH Lindner; Claudia Gragnoli; Jan Schulze; H Rietzsch; C Petzold; H E Schröder; Nancy J Cox; Graeme I Bell
The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships.
Diabetes 1997;46(7):1227-9.
1997: Søren A Urhammer; Søren K Rasmussen; P J Kaisaki; N Oda; K Yamagata; AM Møller; M Fridberg; Lars Hansen; Torben Hansen; Graeme I Bell; Oluf Pedersen
Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.
Diabetologia 1997;40(4):473-5.
1997: Martine Vaxillaire; M Rouard; K Yamagata; Naohisa Oda; Pamela J Kaisaki; V V Boriraj; J C Chevre; V Boccio; R D Cox; G Mark Lathrop; P Dussoix; Jacques Philippe; José Timsit; Guillaume Charpentier; Gilberto Velho; Graeme I Bell; philippe froguel
Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
Human molecular genetics 1997;6(4):583-6.
1997: Torben Hansen; H Eiberg; M Rouard; Martine Vaxillaire; AM Møller; Søren K Rasmussen; M Fridberg; Søren A Urhammer; J J Holst; Katrine Almind; Søren M Echwald; Lars Hansen; Graeme I Bell; Oluf Pedersen
Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
Diabetes 1997;46(4):726-30.
1997: Timothy M Frayling; M P Bulamn; Sian Ellard; M Appleton; MJ Dronsfield; A D Mackie; J D Baird; P J Kaisaki; K Yamagata; Graeme I Bell; Stephen C Bain; Andrew T Hattersley
Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
Diabetes 1997;46(4):720-5.
1997: Pamela J Kaisaki; Stephan Menzel; TH Lindner; Naohisa Oda; Ilona Rjasanowski; J Sahm; G Meincke; Jan Schulze; H Schmechel; C Petzold; H M Ledermann; G Sachse; V V Boriraj; R Menzel; Wolfgang Kerner; R C Turner; K Yamagata; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.
Diabetes 1997;46(3):528-35.
1996: K Yamagata; H Furuta; Naohisa Oda; Pamela J Kaisaki; Stephan Menzel; Nancy J Cox; SS Fajans; STEFANO SIGNORINI; M Stoffel; Graeme I Bell
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Nature 1996;384(6608):458-60.
1996: K Yamagata; Naohisa Oda; Pamela J Kaisaki; Stephan Menzel; H Furuta; Martine Vaxillaire; L Southam; R D Cox; G Mark Lathrop; V V Boriraj; X Chen; Nancy J Cox; Y Oda; H Yano; Michelle M Le Beau; S Yamada; H Nishigori; J Takeda; SS Fajans; Andrew T Hattersley; Naoko Iwasaki; Torben Hansen; Oluf Pedersen; Kenneth S Polonsky; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: Elena V Semina; N A Datson; N J Leysens; B U Zabel; J C Carey; Graeme I Bell; P Bitoun; C Lindgren; T Stevenson; Rune R Frants; Gert-Jan B van Ommen; Jeffrey C Murray
Exclusion of epidermal growth factor and high-resolution physical mapping across the Rieger syndrome locus.
American journal of human genetics 1996;59(6):1288-96.
1996: Maria M Byrne; Jeppe Sturis; Stephan Menzel; K Yamagata; SS Fajans; MJ Dronsfield; S C Bain; Andrew T Hattersley; Gilberto Velho; philippe froguel; Graeme I Bell; Kenneth S Polonsky
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
Diabetes 1996;45(11):1503-10.
1996: A Hino; Y Tokuyama; Bryce Weir; J Takeda; H Yano; Graeme I Bell; R Loch Macdonald
Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys.
Neurosurgery 1996;39(3):562-7; discussion 567-8.
1996: H Furuta; S Nishi; Michelle M Le Beau; A A Fernald; H Yano; Graeme I Bell
Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization.
Genomics 1996;36(1):206-9.
1996: S R Glaum; M Hara; Vytautas P Bindokas; C C Lee; Kenneth S Polonsky; Graeme I Bell; Richard J Miller
Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus.
Molecular pharmacology 1996;50(2):230-5.
1996: A Hino; Y Tokuyama; M Kobayashi; M Yano; Bryce Weir; J Takeda; X Wang; Graeme I Bell; R Loch Macdonald
Increased expression of endothelin B receptor mRNA following subarachnoid hemorrhage in monkeys.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(4):688-97.
1996: K Yamagata; J Takeda; Stephan Menzel; X Chen; S Eng; L R Lim; Patrick Concannon; Craig L Hanis; Richard S Spielman; Nancy J Cox; Graeme I Bell
Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.
Diabetologia 1996;39(6):725-30.
1996: Craig L Hanis; Eric Boerwinkle; R Chakraborty; D L Ellsworth; Patrick Concannon; B Stirling; V A Morrison; B Wapelhorst; Richard S Spielman; K J Gogolin-Ewens; J M Shepard; S R Williams; N Risch; D Hinds; Naoko Iwasaki; Makiko Ogata; Y Omori; C Petzold; H Rietzch; H E Schröder; J Schulze; Nancy J Cox; Stephan Menzel; V V Boriraj; X Chen; L R Lim; TH Lindner; L E Mereu; Y Q Wang; Kun-san Xiang; K Yamagata; Y Yang; Graeme I Bell
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.
Nature genetics 1996;13(2):161-6.
1996: Richard J Miller; Graeme I Bell
JAK/STAT eats the fat.
Trends in neurosciences 1996;19(5):159-61.
1996: M Stoffel; Michelle M Le Beau; Rafael Espinosa; S F Bohlander; D Le Paslier; D Cohen; Kun-san Xiang; Nancy J Cox; SS Fajans; Graeme I Bell
A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3937-41.
1996: Y Tokuyama; Z Fan; H Furuta; Jonathan C Makielski; Kenneth S Polonsky; Graeme I Bell; H Yano
Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1996;220(3):532-8.
1996: V Gambino; Stephan Menzel; J B Trabb; Kun-san Xiang; TH Lindner; A Louït; E Chen; L E Mereu; H Furuta; Naoko Iwasaki; M Kawamura; Yasue Omori; H Rietzsch; Jan Schulze; H E Schröder; Patrick Concannon; Craig L Hanis; Richard S Spielman; K Yamagata; Nancy J Cox; Graeme I Bell
An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM.
Diabetes 1996;45(3):291-4.
1996: Naoko Iwasaki; M Kawamura; K Yamagata; N J Cox; S Karibe; H Ohgawara; N Inagaki; S Seino; Graeme I Bell; Yasue Omori
Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese.
Diabetes 1996;45(2):267-9.
1996: Graeme I Bell; S J Pilkis; Irene T Weber; Kenneth S Polonsky
Glucokinase mutations, insulin secretion, and diabetes mellitus.
Annual review of physiology 1996;58():171-86.
1996: Michael W Roe; J F Worley; Y Tokuyama; Louis H Philipson; Jeppe Sturis; J Tang; I D Dukes; Graeme I Bell; Kenneth S Polonsky
NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.
The American journal of physiology 1996;270(1 Pt 1):E133-40.
1995: B Stirling; Nancy J Cox; Graeme I Bell; Craig L Hanis; Richard S Spielman; Patrick Concannon
Linkage studies in NIDDM with markers near the sulphonylurea receptor gene.
Diabetologia 1995;38(12):1479-81.
1995: Y Tokuyama; Jeppe Sturis; A M DePaoli; J Takeda; M Stoffel; J Tang; X Sun; Kenneth S Polonsky; Graeme I Bell
Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
Diabetes 1995;44(12):1447-57.
1995: J Takeda; Rafael Espinosa; S Eng; Michelle M Le Beau; Graeme I Bell
Chromosomal assignment and tissue distribution of novel expressed sequence tags from a human pancreatic islet cDNA library.
Genomics 1995;29(1):276-81.
1995: M Stoffel; A A Fernald; Michelle M Le Beau; Graeme I Bell
Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization.
Genomics 1995;28(3):607-9.
1995: Terry Reisine; Graeme I Bell
Molecular biology of somatostatin receptors.
Endocrine reviews 1995;16(4):427-42.
1995: Terry Reisine; Graeme I Bell
Molecular properties of somatostatin receptors.
Neuroscience 1995;67(4):777-90.
1995: B Stirling; Nancy J Cox; Graeme I Bell; Craig L Hanis; Richard S Spielman; Patrick Concannon
Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.
Diabetes 1995;44(8):999-1001.
1995: M Stoffel; Y Tokuyama; J B Trabb; Michael S German; M L Tsaar; Lily Yeh Jan; Kenneth S Polonsky; Graeme I Bell
Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1995;212(3):894-9.
1995: M Stoffel; R Stein; C V Wright; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
Genomics 1995;28(1):125-6.
1995: M Raafat El-Maghrabi; A J Lange; W Jiang; K Yamagata; M Stoffel; J Takeda; A A Fernald; Michelle M Le Beau; Graeme I Bell; L Baker
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
Genomics 1995;27(3):520-5.
1995: Y Tokuyama; M Hara; E M Jones; Z Fan; Graeme I Bell
Cloning of rat and mouse P2Y purinoceptors.
Biochemical and biophysical research communications 1995;211(1):211-8.
1995: Maria M Byrne; Jeppe Sturis; SS Fajans; F J Ortiz; Anjanette Michel Stoltz; M Stoffel; M J Smith; Graeme I Bell; Jeffrey B Halter; Kenneth S Polonsky
Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
Diabetes 1995;44(6):699-704.
1995: R E Rowe; B Wapelhorst; Graeme I Bell; N Risch; Richard S Spielman; Patrick Concannon
Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.
Nature genetics 1995;10(2):240-2.
1995: J Takeda; A A Fernald; K Yamagata; Michelle M Le Beau; Graeme I Bell
Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.
Genomics 1995;26(3):638-9.
1995: Naoko Iwasaki; H Ohgawara; H Nagahara; M Kawamura; Graeme I Bell; Yasue Omori
Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.
Acta diabetologica 1995;32(1):17-22.
1995: B Wapelhorst; Graeme I Bell; N Risch; R S Spielman; Patrick Concannon
Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.
Autoimmunity 1995;21(2):127-30.
1995: Graeme I Bell; K Yasuda; H Kong; S F Law; K Raynor; Terry Reisine
Molecular biology of somatostatin receptors.
Ciba Foundation symposium 1995;190():65-79; discussion 80-8.
1995: E M Jones; A Fernald; Graeme I Bell; Michelle M Le Beau
Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization.
Cytogenetics and cell genetics 1995;71(3):211.
1994: A M DePaoli; Graeme I Bell; M Stoffel
G protein-activated inwardly rectifying potassium channel (GIRK1/KGA) mRNA in adult rat heart and brain by in situ hybridization histochemistry.
Molecular and cellular neurosciences 1994;5(6):515-22.
1994: M Tallent; Marc A Dichter; Graeme I Bell; Terry Reisine
The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells.
Neuroscience 1994;63(4):1033-40.
1994: O Blondel; Graeme I Bell; M Moody; Richard J Miller; S J Gibbons
Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells.
The Journal of biological chemistry 1994;269(44):27167-70.
1994: M Stoffel; Rafael Espinosa; J B Trabb; Michelle M Le Beau; Graeme I Bell
Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.
Genomics 1994;23(3):697-9.
1994: E M Jones; Stephan Menzel; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell; J Takeda
Localization of the gene encoding a neutral amino acid transporter-like protein to human chromosome band 19q13.3 and characterization of a simple sequence repeat DNA polymorphism.
Genomics 1994;23(2):490-1.
1994: S J Pilkis; Irene T Weber; Robert W Harrison; Graeme I Bell
Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.
The Journal of biological chemistry 1994;269(35):21925-8.
1994: K Raynor; H Kong; John Hines; G Kong; J Benovic; K Yasuda; Graeme I Bell; Terry Reisine
Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1381-6.
1994: H Kong; K Raynor; H Yano; J Takeda; Graeme I Bell; Terry Reisine
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8042-6.
1994: O Blondel; M M Moody; A M Depaoli; Alan H Sharp; Christopher A Ross; Hewson H Swift; Graeme I Bell
Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7777-81.
1994: M A Theveniau; K Yasuda; Graeme I Bell; Terry Reisine
Immunological detection of isoforms of the somatostatin receptor subtype, SSTR2.
Journal of neurochemistry 1994;63(2):447-55.
1994: H Yano; Louis H Philipson; J L Kugler; Y Tokuyama; Elizabeth M Davis; Michelle M Le Beau; Deborah J Nelson; Graeme I Bell; J Takeda
Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.
Molecular pharmacology 1994;45(5):854-60.
1994: Jeppe Sturis; Irwin Kurland; Maria M Byrne; E Mosekilde; philippe froguel; S J Pilkis; Graeme I Bell; Kenneth S Polonsky
Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
Diabetes 1994;43(5):718-23.
1994: M Stoffel; Rafael Espinosa; K L Powell; Louis H Philipson; Michelle M Le Beau; Graeme I Bell
Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism.
Genomics 1994;21(1):254-6.
1994: S F Law; S Zaina; R Sweet; K Yasuda; Graeme I Bell; J Stadel; Terry Reisine
Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.
Molecular pharmacology 1994;45(4):587-90.
1994: Stephan Menzel; M Stoffel; Rafael Espinosa; A A Fernald; Michelle M Le Beau; Graeme I Bell
Localization of the glucagon receptor gene to human chromosome band 17q25.
Genomics 1994;20(2):327-8.
1994: H Kong; A M DePaoli; Christopher Breder; K Yasuda; Graeme I Bell; Terry Reisine
Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry.
Neuroscience 1994;59(1):175-84.
1994: Maria M Byrne; Jeppe Sturis; Karine Clément; Nathalie Vionnet; M E Pueyo; M Stoffel; J Takeda; Philippe Passa; D Cohen; Graeme I Bell
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
The Journal of clinical investigation 1994;93(3):1120-30.
1994: K Yasuda; Rafael Espinosa; J Takeda; Michelle M Le Beau; Graeme I Bell
Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.
Genomics 1994;19(3):596-7.
1994: K Raynor; H Kong; Yan Chen; K Yasuda; Lei Yu; Graeme I Bell; Terry Reisine
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Molecular pharmacology 1994;45(2):330-4.
1994: J Takeda; C L Blackburn; Stephan Menzel; H Yano; Graeme I Bell
Dinucleotide repeat polymorphism at D9S328E (EST hbc220).
Human molecular genetics 1994;3(2):387.
1993: M Lehto; Kun-san Xiang; M Stoffel; Rafael Espinosa; L C Groop; Michelle M Le Beau; Graeme I Bell
Human hexokinase II: localization of the polymorphic gene to chromosome 2.
Diabetologia 1993;36(12):1299-302.
1993: Diane Roulston; Rafael Espinosa; M Stoffel; Graeme I Bell; Michelle M Le Beau
Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20.
Blood 1993;82(11):3424-9.
1993: Terry Reisine; Graeme I Bell
Molecular biology of opioid receptors.
Trends in neurosciences 1993;16(12):506-10.
1993: H Kong; K Raynor; K Yasuda; S T Moe; P S Portoghese; Graeme I Bell; Terry Reisine
A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.
The Journal of biological chemistry 1993;268(31):23055-8.
1993: T S Seo; Tadashi Hanabusa; S Ohagi; Donald F Steiner; Graeme I Bell
Dinucleotide repeat polymorphism in the NEC2 gene.
Human molecular genetics 1993;2(11):1983.
1993: Terry Reisine; H Kong; K Raynor; H Yano; J Takeda; K Yasuda; Graeme I Bell
Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.
Molecular pharmacology 1993;44(5):1016-20.
1993: J Takeda; H Yano; S Eng; Y Zeng; Graeme I Bell
A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones.
Human molecular genetics 1993;2(11):1793-8.
1993: Graeme I Bell; Charles F Burant; J Takeda; G W Gould
Structure and function of mammalian facilitative sugar transporters.
The Journal of biological chemistry 1993;268(26):19161-4.
1993: K Yasuda; Rafael Espinosa; Elizabeth M Davis; Michelle M Le Beau; Graeme I Bell
Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.
Genomics 1993;17(3):785-6.
1993: M Stoffel; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6.
Diabetes 1993;42(8):1215-8.
1993: Y Hayashi; Y Mori; Onno Eilard Janssen; T Sunthornthepvarakul; Roy E Weiss; K Takeda; M Weinberg; H Seo; Graeme I Bell; Samuel Refetoff
Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.
Molecular endocrinology (Baltimore, Md.) 1993;7(8):1049-60.
1993: K Raynor; Anne-Marie O'Carroll; H Kong; K Yasuda; L C Mahan; Graeme I Bell; Terry Reisine
Characterization of cloned somatostatin receptors SSTR4 and SSTR5.
Molecular pharmacology 1993;44(2):385-92.
1993: H Kong; K Raynor; K Yasuda; Graeme I Bell; Terry Reisine
Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.
Molecular pharmacology 1993;44(2):380-4.
1993: K Yasuda; K Raynor; H Kong; Christopher Breder; J Takeda; Terry Reisine; Graeme I Bell
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6736-40.
1993: Y Iwashima; William Pugh; A M Depaoli; J Takeda; S Seino; Graeme I Bell; Kenneth S Polonsky
Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
Diabetes 1993;42(7):948-55.
1993: Nathalie Vionnet; Graeme I Bell
Identification of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and linkage to five markers on chromosome 19q.
Diabetes 1993;42(6):930-2.
1993: E B Rand; A M Depaoli; Nicholas O Davidson; Graeme I Bell; Charles F Burant
Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5.
The American journal of physiology 1993;264(6 Pt 1):G1169-76.
1993: K Raynor; W A Murphy; D H Coy; J E Taylor; J P Moreau; K Yasuda; Graeme I Bell; Terry Reisine
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
Molecular pharmacology 1993;43(6):838-44.
1993: O Blondel; J Takeda; H Janssen; S Seino; Graeme I Bell
Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.
The Journal of biological chemistry 1993;268(15):11356-63.
1993: S F Law; K Yasuda; Graeme I Bell; Terry Reisine
Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2.
The Journal of biological chemistry 1993;268(15):10721-7.
1993: Ann Louise Olson; M L Liu; W Scott Moye-Rowley; John B Buse; Graeme I Bell; Jeffrey Pessin
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
The Journal of biological chemistry 1993;268(13):9839-46.
1993: M Stoffel; Rafael Espinosa; Susanna R Keller; G E Lienhard; Michelle M Le Beau; Graeme I Bell
Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism.
Diabetologia 1993;36(4):335-7.
1993: M Stoffel; Graeme I Bell
Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene.
Diabetologia 1993;36(2):170-1.
1993: Louis H Philipson; R L Eddy; TB Shows; Graeme I Bell
Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1.
Genomics 1993;15(2):463-4.
1993: M Lehto; M Stoffel; L Groop; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Assignment of the gene encoding glycogen synthase (GYS) to human chromosome 19, band q13.3.
Genomics 1993;15(2):460-1.
1993: Yoshihiko Yamada; M Stoffel; Rafael Espinosa; K S Xiang; M Seino; S Seino; Michelle M Le Beau; Graeme I Bell
Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.
Genomics 1993;15(2):449-52.
1993: M Stoffel; Kun-san Xiang; Rafael Espinosa; Nancy J Cox; Michelle M Le Beau; Graeme I Bell
cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
Human molecular genetics 1993;2(1):1-4.
1993: Graeme I Bell; Terry Reisine
Molecular biology of somatostatin receptors.
Trends in neurosciences 1993;16(1):34-8.
1992: Y Yamada; T Reisine; S F Law; Yu Ihara; A Kubota; S Kagimoto; M Seino; Yutaka Seino; Graeme I Bell; S Seino
Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2136-42.
1992: John B Buse; K Yasuda; T P Lay; T S Seo; Ann Louise Olson; Jeffrey Pessin; J H Karam; S Seino; Graeme I Bell
Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
Diabetes 1992;41(11):1436-45.
1992: M Stoffel; Kun-san Xiang; Graeme I Bell
Dinucleotide repeat polymorphism at the human ribophorin II locus (RPN2) on chromosome 20q.
Human molecular genetics 1992;1(8):656.
1992: Charles F Burant; Graeme I Bell
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins.
Biochemistry 1992;31(42):10414-20.
1992: K Yasuda; S Rens-Domiano; Christopher Breder; S F Law; Clifford B Saper; Terry Reisine; Graeme I Bell
Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
The Journal of biological chemistry 1992;267(28):20422-8.
1992: Christopher Breder; Yoshihiko Yamada; K Yasuda; S Seino; Clifford B Saper; Graeme I Bell
Differential expression of somatostatin receptor subtypes in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(10):3920-34.
1992: A Sakurai; Graeme I Bell; Leslie J DeGroot
Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA1) on chromosome 17.
Human molecular genetics 1992;1(7):553.
1992: M Stoffel; P Patel; Y M Dennis Lo; Andrew T Hattersley; A M Lucassen; R Page; J I Bell; Graeme I Bell; RC Turner; james wainscoat
Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
Nature genetics 1992;2(2):153-6.
1992: Jeffrey C Murray; S R Bennett; A E Kwitek; K W Small; A Schinzel; Wallace L M Alward; J L Weber; Graeme I Bell; K H Buetow
Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4.
Nature genetics 1992;2(1):46-9.
1992: S Nishi; M Stoffel; Kun-san Xiang; TB Shows; Graeme I Bell; J Takeda
Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13.
Diabetologia 1992;35(8):743-7.
1992: S Seino; Yoshihiko Yamada; Rafael Espinosa; Michelle M Le Beau; Graeme I Bell
Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3.
Genomics 1992;13(4):1375-7.
1992: I A Drummond; S L Madden; P Rohwer-Nutter; Graeme I Bell; Vikas P Sukhatme; Frank J Rauscher
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
Science (New York, N.Y.) 1992;257(5070):674-8.
1992: Charles F Burant; J Takeda; Edith Brot-Laroche; Graeme I Bell; Nicholas O Davidson
Fructose transporter in human spermatozoa and small intestine is GLUT5.
The Journal of biological chemistry 1992;267(21):14523-6.
1992: S Rens-Domiano; S F Law; Y Yamada; S Seino; Graeme I Bell; Terry Reisine
Pharmacological properties of two cloned somatostatin receptors.
Molecular pharmacology 1992;42(1):28-34.
1992: M L Liu; Ann Louise Olson; W Scott Moye-Rowley; John B Buse; Graeme I Bell; Jeffrey Pessin
Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
The Journal of biological chemistry 1992;267(17):11673-6.
1992: Nathalie Vionnet; M Stoffel; J Takeda; K Yasuda; Graeme I Bell; Habib Zouali; Suzanne Lesage; Gilberto Velho; F Iris; Philippe Passa
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
Nature 1992;356(6371):721-2.
1992: Nancy J Cox; Kun-san Xiang; SS Fajans; Graeme I Bell
Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young.
Diabetes 1992;41(4):401-7.
1992: M Stoffel; Graeme I Bell
Microsatellite polymorphism in the human platelet glycoprotein IIIa gene (GP3A) on chromosome 17.
Nucleic acids research 1992;20(5):1172.
1992: S Seino; Graeme I Bell; W H Li
Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys.
Molecular biology and evolution 1992;9(2):193-203.
1992: Nicholas O Davidson; A M Hausman; C A Ifkovits; John B Buse; G W Gould; Charles F Burant; Graeme I Bell
Human intestinal glucose transporter expression and localization of GLUT5.
The American journal of physiology 1992;262(3 Pt 1):C795-800.
1992: S Seino; L Chen; M Seino; O Blondel; J Takeda; J H Johnson; Graeme I Bell
Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):584-8.
1992: S Nagamatsu; Jon M Kornhauser; Charles F Burant; S Seino; K E Mayo; Graeme I Bell
Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.
The Journal of biological chemistry 1992;267(1):467-72.
1992: Jeffrey Pessin; Graeme I Bell
Mammalian facilitative glucose transporter family: structure and molecular regulation.
Annual review of physiology 1992;54():911-30.
1992: Yoshihiko Yamada; S R Post; K Wang; H S Tager; Graeme I Bell; S Seino
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):251-5.
1991: N Iwasaki; Kun-san Xiang; M Seino; Graeme I Bell
Dinucleotide repeat polymorphism in D20S17 (CRI-L127).
Nucleic acids research 1991;19(24):6970.
1991: Kun-san Xiang; G Phillippe; M Seino; K Bonham; D J Fugita; Graeme I Bell
Dinucleotide repeat polymorphism in the human SRC gene on chromosome 20.
Nucleic acids research 1991;19(24):6967.
1991: A Sakurai; Graeme I Bell; Leslie J DeGroot
Dinucleotide repeat polymorphism in the human thyroid hormone receptor beta gene (THRB) on chromosome 3.
Nucleic acids research 1991;19(23):6661.
1991: Kun-san Xiang; M Granqvist; M Seino; S Seino; Graeme I Bell
Microsatellite polymorphism in human insulin receptor gene (INSR) on chromosome 19.
Nucleic acids research 1991;19(18):5094.
1991: M Granqvist; Kun-san Xiang; M Seino; H Fukumoto; Graeme I Bell
Dinucleotide repeat polymorphism in human GLUT2/liver facilitative glucose transporter gene on chromosome 3.
Nucleic acids research 1991;19(17):4791.
1991: M Granqvist; Kun-san Xiang; M Seino; Graeme I Bell
Dinucleotide repeat polymorphism in Gs-alpha subunit gene (GNAS1) on chromosome 20.
Nucleic acids research 1991;19(16):4569.
1991: S Ohagi; M Nishi; Graeme I Bell; J W Ensinck; Donald F Steiner
Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris).
Diabetologia 1991;34(8):555-8.
1991: Yoshihiko Yamada; Kun-san Xiang; Graeme I Bell; S Seino; M Nishi
Dinucleotide repeat polymorphism in a gene on chromosome 20 encoding a G-protein coupled receptor (D20S32e).
Nucleic acids research 1991;19(9):2519.
1991: Graeme I Bell
Lilly lecture 1990. Molecular defects in diabetes mellitus.
Diabetes 1991;40(4):413-22.
1991: S Wu; Kun-san Xiang; Graeme I Bell
Dinucleotide repeat polymorphism in the human glucagon gene (GCG).
Nucleic acids research 1991;19(5):1163.
1991: Donald F Steiner; S Ohagi; S Nagamatsu; Graeme I Bell; M Nishi
Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes?
Diabetes 1991;40(3):305-9.
1991: Graeme I Bell; Kun-san Xiang; M V Newman; S H Wu; L G Wright; SS Fajans; Richard S Spielman; Nancy J Cox
Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1484-8.
1991: Louis H Philipson; R E Hice; K Schaefer; J LaMendola; Graeme I Bell; D J Nelson; Donald F Steiner
Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):53-7.
1991: Charles F Burant; William I Sivitz; H Fukumoto; T Kayano; S Nagamatsu; S Seino; Jeffrey Pessin; Graeme I Bell
Mammalian glucose transporters: structure and molecular regulation.
Recent progress in hormone research 1991;47():349-87; discussion 387-8.
1990: Louis H Philipson; K Schaefer; J LaMendola; Graeme I Bell; Donald F Steiner
Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4.
Nucleic acids research 1990;18(23):7160.
1990: M Nishi; Graeme I Bell; Donald F Steiner
Sequence of a cDNA encoding Syrian hamster islet amyloid polypeptide precursor.
Nucleic acids research 1990;18(22):6726.
1990: Michael A Becker; S A Heidler; Graeme I Bell; S Seino; Michelle M Le Beau; Carol A Westbrook; W Neuman; Lawrence J Shapiro; Thuluvancheri K Mohandas; Blake J Roessler
Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.
Genomics 1990;8(3):555-61.
1990: M Nishi; Graeme I Bell; Donald F Steiner
Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1990;33(10):628-30.
1990: T Kayano; Charles F Burant; H Fukumoto; G W Gould; Yao-Shan Fan; R L Eddy; M G Byers; TB Shows; S Seino; Graeme I Bell
Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).
The Journal of biological chemistry 1990;265(22):13276-82.
1990: S Wu; S Seino; Graeme I Bell
Human collagen, type II, alpha 1, (COL2A1) gene: VNTR polymorphism detected by gene amplification.
Nucleic acids research 1990;18(10):3102.
1990: E T Shapiro; Graeme I Bell; Kenneth S Polonsky; Arthur H Rubenstein; M C Kew; H S Tager
Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II.
The Journal of clinical investigation 1990;85(5):1672-9.
1990: William I Sivitz; S L DeSautel; T Kayano; Graeme I Bell; Jeffrey Pessin
Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin.
Molecular endocrinology (Baltimore, Md.) 1990;4(4):583-8.
1990: M Nishi; T Sanke; S Nagamatsu; Graeme I Bell; Donald F Steiner
Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits.
The Journal of biological chemistry 1990;265(8):4173-6.
1990: Graeme I Bell; T Kayano; John B Buse; Charles F Burant; J Takeda; D Lin; H Fukumoto; S Seino
Molecular biology of mammalian glucose transporters.
Diabetes care 1990;13(3):198-208.
1990: S Seino; M Seino; Graeme I Bell
Human insulin-receptor gene.
Diabetes 1990;39(2):129-33.
1990: S Seino; M Seino; Graeme I Bell
Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.
Diabetes 1990;39(1):123-8.
1989: M Nishi; T Sanke; S Seino; R L Eddy; Yao-Shan Fan; M G Byers; TB Shows; Graeme I Bell; Donald F Steiner
Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1775-81.
1989: A Sakurai; K Takeda; K Ain; P Ceccarelli; A Nakai; S Seino; Graeme I Bell; Samuel Refetoff; Leslie J DeGroot
Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8977-81.
1989: S Nishi; M Newman; Graeme I Bell
HincII RFLP at the human hexokinase I (HK1) locus on chromosome 10.
Nucleic acids research 1989;17(18):7547.
1989: H H Ardinger; K H Buetow; Graeme I Bell; J Bardach; D R VanDemark; Jeffrey C Murray
Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.
American journal of human genetics 1989;45(3):348-53.
1989: S Wu; S Seino; Graeme I Bell
Human antithrombin II (AT3) gene length polymorphism revealed by the polymerase chain reaction.
Nucleic acids research 1989;17(15):6433.
1989: M Nishi; S J Chan; S Nagamatsu; Graeme I Bell; Donald F Steiner
Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5738-42.
1989: Nancy J Cox; Graeme I Bell
Disease associations. Chance, artifact, or susceptibility genes?
Diabetes 1989;38(8):947-50.
1989: Graeme I Bell; J C Murray; Y Nakamura; T Kayano; R L Eddy; Yao-Shan Fan; M G Byers; TB Shows
Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13.
Diabetes 1989;38(8):1072-5.
1989: William I Sivitz; S L DeSautel; T Kayano; Graeme I Bell; Jeffrey Pessin
Regulation of glucose transporter messenger RNA in insulin-deficient states.
Nature 1989;340(6228):72-4.
1989: H Yano; Yutaka Seino; J Fujita; Y Yamada; N Inagaki; J Takeda; Graeme I Bell; R L Eddy; Yao-Shan Fan; M G Byers
Exon-intron organization, expression, and chromosomal localization of the human motilin gene.
FEBS letters 1989;249(2):248-52.
1989: N Inagaki; Yutaka Seino; J Takeda; H Yano; Y Yamada; Graeme I Bell; R L Eddy; Y Fukushima; M G Byers; T B Shows
Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.
Molecular endocrinology (Baltimore, Md.) 1989;3(6):1014-21.
1989: H Fukumoto; T Kayano; John B Buse; Y Edwards; P F Pilch; Graeme I Bell; S Seino
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.
The Journal of biological chemistry 1989;264(14):7776-9.
1989: N Leysens; Jeffrey C Murray; Graeme I Bell
A KpnI polymorphism for the human insulin-responsive glucose transporter gene (GLUT4) on chromosome 17.
Nucleic acids research 1989;17(9):3621.
1989: K Takeda; Y Mori; S Sobieszczyk; H Seo; M Dick; F Watson; Irwin L Flink; S Seino; Graeme I Bell; Samuel Refetoff
Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.
The Journal of clinical investigation 1989;83(4):1344-8.
1989: Y Mori; S Seino; K Takeda; Irwin L Flink; Y Murata; Graeme I Bell; Samuel Refetoff
A mutation causing reduced biological activity and stability of thyroxine-binding globulin probably as a result of abnormal glycosylation of the molecule.
Molecular endocrinology (Baltimore, Md.) 1989;3(3):575-9.
1989: S Seino; Graeme I Bell
Alternative splicing of human insulin receptor messenger RNA.
Biochemical and biophysical research communications 1989;159(1):312-6.
1989: Kun-san Xiang; Nancy J Cox; N Sanz; P Huang; J H Karam; Graeme I Bell
Insulin-receptor and apolipoprotein genes contribute to development of NIDDM in Chinese Americans.
Diabetes 1989;38(1):17-23.
1988: S Nishi; S Seino; Graeme I Bell
Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.
Biochemical and biophysical research communications 1988;157(3):937-43.
1988: T Sanke; Graeme I Bell; C Sample; Arthur H Rubenstein; Donald F Steiner
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.
The Journal of biological chemistry 1988;263(33):17243-6.
1988: A Nakai; A Sakurai; Graeme I Bell; Leslie J DeGroot
Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1087-92.
1988: T Kayano; H Fukumoto; R L Eddy; Yao-Shan Fan; M G Byers; TB Shows; Graeme I Bell
Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
The Journal of biological chemistry 1988;263(30):15245-8.
1988: Nancy J Cox; Graeme I Bell; Kun-san Xiang
Linkage disequilibrium in the human insulin/insulin-like growth factor II region of human chromosome II.
American journal of human genetics 1988;43(4):495-501.
1988: H H Ardinger; R H Ardinger; Graeme I Bell; Jeffrey C Murray
RFLP for the human transforming growth factor beta-1 gene (TGFB) on chromosome 19.
Nucleic acids research 1988;16(16):8202.
1988: S Seino; C D Blackstone; S J Chan; J Whittaker; Graeme I Bell; Donald F Steiner
Appalachian spring: variations on ancient gastro-entero-pancreatic themes in New World mammals.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):430-5.
1988: Yasunao Yoshimasa; S Seino; J Whittaker; T Kakehi; A Kosaki; Hideshi Kuzuya; Hiroshi Imura; Graeme I Bell; Donald F Steiner
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
Science (New York, N.Y.) 1988;240(4853):784-7.
1988: H Fukumoto; S Seino; Hiroshi Imura; Y Seino; Graeme I Bell
Characterization and expression of human HepG2/erythrocyte glucose-transporter gene.
Diabetes 1988;37(5):657-61.
1988: V McCreary; Sreedharan Kartha; Graeme I Bell; F Gary Toback
Sequence of a human kidney cDNA clone encoding thymosin beta 10.
Biochemical and biophysical research communications 1988;152(2):862-6.
1988: Kun-san Xiang; Nancy J Cox; Graeme I Bell
Apa I and Sst I RFLPs at the insulin-like growth factor II (IGF2) locus on chromosome 11.
Nucleic acids research 1988;16(8):3599.
1988: A Nakai; S Seino; A Sakurai; I Szilak; Graeme I Bell; Leslie J DeGroot
Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2781-5.
1987: Kun-san Xiang; Nancy J Cox; J H Karam; Graeme I Bell
Bgl II RFLP at the human erythrocyte/HepG2-type glucose transporter (GLUT) locus on chromosome 1.
Nucleic acids research 1987;15(21):9101.
1987: S Seino; Donald F Steiner; Graeme I Bell
Sequence of a New World primate insulin having low biological potency and immunoreactivity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7423-7.
1987: Kun-san Xiang; J H Karam; Graeme I Bell
BamHI RFLP at the insulin-like growth factor II (IGF2) locus on chromosome 11.
Nucleic acids research 1987;15(18):7655.
1987: Kun-san Xiang; Nancy J Cox; R A Hallewell; Graeme I Bell
Multiple Taq I RFLPs at the human manganese superoxide dismutase (S0D2) locus on chromosome 6.
Nucleic acids research 1987;15(18):7654.
1987: Graeme I Bell; Kun-san Xiang; S Horita; N Sanz; J H Karam
The molecular genetics of diabetes mellitus.
Ciba Foundation symposium 1987;130():167-83.
1985: S Elbein; Peter Rotwein; M A Permutt; Graeme I Bell; N Sanz; J H Karam
Lack of association of the polymorphic locus in the 5'-flanking region of the human insulin gene and diabetes in American blacks.
Diabetes 1985;34(5):433-9.