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John Bell

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Mi Kyung Kim; Seong-Geun Kim; David H Kirn; Jun Woo Lee; Yu Kyoung Lee; Anne Moon; Byeong Ho Park; John C Bell; Caroline J Breitbach; Mong Cho; Jeong Heo; Dae Hwan Kang; Tae-Ho Hwang
Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans.
Byram W Bridle; Alfredo Capretta; Lan Chen; Jean-Simon Diallo; Rongqiao He; Chantal G Lemay; Brian Lichty; Andrew Nguyen; Jonathan POL; John C Bell; Jonathan Bramson; Yonghong Wan
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Jeong Heo; Theresa Hickman; Tae-Ho Hwang; Chang Won Kim; Mi Kyeong Kim; John C Bell; Mark Bloomston; Caroline J Breitbach; James Burke; Mong Cho; Hyun Cheol Chung; Manijeh Daneshmand; Kara Dubois; Yeon Sook Lee; Riccardo Lencioni; Ho Yeong Lim; Lara Longpre; Anne Moon; Minhtran Ngo; Richard Patt; Tony Reid; Byung-Geon Rhee; Cliona Rooney; Steven Rose; Leyo Ruo; David H Kirn
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.

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All Publications

2013: Mi Kyung Kim; Seong-Geun Kim; David H Kirn; Jun Woo Lee; Yu Kyoung Lee; Anne Moon; Byeong Ho Park; John C Bell; Caroline J Breitbach; Mong Cho; Jeong Heo; Dae Hwan Kang; Tae-Ho Hwang
Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans.
Science translational medicine 2013;5(185):185ra63.
2013: Byram W Bridle; Alfredo Capretta; Lan Chen; Jean-Simon Diallo; Rongqiao He; Chantal G Lemay; Brian Lichty; Andrew Nguyen; Jonathan POL; John C Bell; Jonathan Bramson; Yonghong Wan
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(4):887-94.
2013: Jeong Heo; Theresa Hickman; Tae-Ho Hwang; Chang Won Kim; Mi Kyeong Kim; John C Bell; Mark Bloomston; Caroline J Breitbach; James Burke; Mong Cho; Hyun Cheol Chung; Manijeh Daneshmand; Kara Dubois; Yeon Sook Lee; Riccardo Lencioni; Ho Yeong Lim; Lara Longpre; Anne Moon; Minhtran Ngo; Richard Patt; Tony Reid; Byung-Geon Rhee; Cliona Rooney; Steven Rose; Leyo Ruo; David H Kirn
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.
Nature medicine 2013;19(3):329-36.
2013: Caroline J Breitbach; James Burke; Hannah Chen; Mong Cho; Manijeh Daneshmand; Naomi De Silva; Jeong Heo; Tae-Ho Hwang; Carolina Ilkow; Christina Addison; Fernando A Angarita; Rozanne Arulanandam; John C Bell; J Andrea McCart; Anne Moon; Richard Patt; Stephen H Thorne; David H Kirn
Oncolytic vaccinia virus disrupts tumor-associated vasculature in humans.
Cancer research 2013;73(4):1265-75.
2013: Markus J V Vähä-Koskela; Abhirami Ananth; Michelle Becker; Sophie Breton; Jan Brun; Youngmin Choi; Julie Cox; Naomi De Silva; Jean-Simon Diallo; Theresa J Falls; Akseli Hemminki; Ari E Hinkkanen; Fabrice Le Boeuf; Chantal Lemay; Dominic Roy; Clara Sellers; John C Bell
Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma.
Journal of virology 2013;87(4):2363-6.
2013: Lee-Hwa Tai; Jiqing Zhang; Almohanad A Alkayyal; Abhirami A Ananth; Simon Bélanger; John C Bell; Caroline J Breitbach; Christiano Tanese de Souza; Theresa J Falls; David H Kirn; Tiffany Lam; Lundi Ly; Andrew P Makrigiannis; Julia L Rintoul; Rebecca A Auer
Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells.
Cancer research 2013;73(1):97-107.
2012: Afnan Azizi; John C Bell; Gleb G Mironov; Darija Muharemagic; Mohamed Wehbe; Maxim V. Berezovski
Viral quantitative capillary electrophoresis for counting and quality control of RNA viruses.
Analytical chemistry 2012;84(21):9585-91.
2012: Darija Muharemagic; Anna S Zamay; John C Bell; Shahrokh M Ghobadloo; Mahmoud Labib; Maxim V. Berezovski
Anti-Fab aptamers for shielding virus from neutralizing antibodies.
Journal of the American Chemical Society 2012;134(41):17168-77.
2012: Chantal G Lemay; Brian Lichty; Kelley A Parato; Jennifer M Paterson; Julia L Rintoul; David F Stojdl; Vera A Tang; Barbara C Vanderhyden; John C Bell; Byram W Bridle; David P Conrad; Jean-Simon Diallo; Theresa J Falls; Lisa Ferreira; Vanessa Garcia; Kenneth Garson; Agnieszka Kus; Fabrice Le Boeuf; Rozanne Arulanandam; Harold L Atkins; Rebecca C Auer
Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(9):1791-9.
2012: Fabrice Le Boeuf; Nima Niknejad; Jiahu Wang; Johanne I Weberpals; Rebecca Auer; John C Bell; Jim Dimitroulakos
Sensitivity of cervical carcinoma cells to vesicular stomatitis virus-induced oncolysis: potential role of human papilloma virus infection.
International journal of cancer. Journal international du cancer 2012;131(3):E204-15.
2012: Julia L Rintoul; Marianne M Stanford; Lee-Hwa Tai; Yonghong Wan; Harold L Atkins; Rebecca C Auer; Byram W Bridle; Manijeh Daneshmand; Christiano T de Souza; Theresa J Falls; Chantal G Lemay; Brian Lichty; Andrew A Mercer; Pamela S Ohashi; John C Bell
ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(6):1148-57.
2012: Kelley A Parato; Chris Storbeck; Barbara C Vanderhyden; Jiahu Wang; Rebecca Auer; Caroline J Breitbach; Joseph Burns; Jean-Simon Diallo; Laura Evgin; Theresa J Falls; Vanessa Garcia; Kang Hu; Tae-Ho Hwang; Carolina Ilkow; Femina Kanji; David H Kirn; Shane Knowles; Fabrice Le Boeuf; Francois Paradis; John C Bell
The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(4):749-58.
2012: Mahmoud Labib; Darija Muharemagic; Anna S Zamay; John C Bell; Alexey V Chechik; Maxim V. Berezovski
Electrochemical differentiation of epitope-specific aptamers.
Analytical chemistry 2012;84(5):2548-56.
2012: Mahmoud Labib; Darija Muharemagic; Anna S Zamay; John C Bell; Alexey V Chechik; Maxim V. Berezovski
Aptamer-based viability impedimetric sensor for viruses.
Analytical chemistry 2012;84(4):1813-6.
2012: Mahmoud Labib; Darija Muharemagic; Anna S Zamay; John C Bell; Alexey Chechik; Maxim V. Berezovski
Electrochemical sensing of aptamer-facilitated virus immunoshielding.
Analytical chemistry 2012;84(3):1677-86.
2011: Tae-Ho Hwang; John C Bell; Caroline J Breitbach; James Burke; Manijeh Daneshmand; Naomi De Silva; Jean-Simon Diallo; Yeon-Sook Lee; Ta-Chiang Liu; Anne Moon; Kelley A Parato; Antoni Ribas; Joe Stephenson; David H Kirn
A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1913-22.
2011: Gleb G Mironov; Rachel Ozer; John C Bell; Alexey V Chechik; Maxim V. Berezovski
Viral quantitative capillary electrophoresis for counting intact viruses.
Analytical chemistry 2011;83(13):5431-5.
2011: Cory Batenchuk; Simon St-Pierre; Lioudmila Tepliakova; Samyuktha Adiga; Anna Szuto; Nazir Kabbani; John C Bell; Kristin Baetz; Mads Kaern
Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.
Biophysical journal 2011;100(10):L56-8.
2011: Caroline J Breitbach; Naomi S De Silva; Theresa J Falls; Usaf Aladl; Laura Evgin; Jennifer Paterson; Yang Yang Sun; Dominic G Roy; Julia L Rintoul; Manijeh Daneshmand; Kelley Parato; Marianne M Stanford; Brian D Lichty; Aaron Fenster; David Kirn; Harold Atkins; John C Bell
Targeting tumor vasculature with an oncolytic virus.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(5):886-94.
2011: Julia L Rintoul; Nicholas J van Buuren; Jiahu Wang; Michele Barry; David H Evans; Don B Gammon; Kenneth Garson; Karen Jardine; John C Bell
A selectable and excisable marker system for the rapid creation of recombinant poxviruses.
PloS one 2011;6(9):e24643.
2010: Xueqing Lun; Jennifer Chan; Hongyuan Zhou; Beichen Sun; John J P Kelly; Owen Owen Stechishin; John C Bell; Kelley A Parato; Kang Hu; Dominique Vaillant; Jiahu Wang; Ta-Chiang Liu; Caroline Breitbach; David Kirn; Donna L Senger; Peter A Forsyth
Efficacy and safety/toxicity study of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(11):1927-36.
2010: Jan Brun; Dan McManus; Charles Lefebvre; Kang Hu; Theresa Falls; Harold Atkins; John C Bell; J Andrea McCart; Douglas Mahoney; David F Stojdl
Identification of genetically modified Maraba virus as an oncolytic rhabdovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(8):1440-9.
2010: Jean-Simon Diallo; Fabrice Le Boeuf; Frances Lai; Julie Cox; Markus Vaha-Koskela; Hesham Abdelbary; Heather MacTavish; Katherine Waite; Theresa J Falls; Jenny Wang; Ryan Brown; Jan E Blanchard; Eric D Brown; David H Kirn; John Hiscott; Harry Atkins; Brian Lichty; John C Bell
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(6):1123-9.
2010: Fabrice Le Boeuf; Jean-Simon Diallo; J Andrea McCart; Steve Thorne; Theresa Falls; Marianne Stanford; Femina Kanji; Rebecca Auer; Christopher W Brown; Brian D Lichty; Kelley Parato; Harold Atkins; David Kirn; John C Bell
Synergistic interaction between oncolytic viruses augments tumor killing.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(5):888-95.
2010: Laura Evgin; Markus Vähä-Koskela; Julia Rintoul; Theresa J Falls; Fabrice Le Boeuf; John W Barrett; John C Bell; Marianne M Stanford
Potent oncolytic activity of raccoonpox virus in the absence of natural pathogenicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(5):896-902.
2010: Naomi De Silva; Harold Atkins; David H Kirn; John C Bell; Caroline J Breitbach
Double trouble for tumours: exploiting the tumour microenvironment to enhance anticancer effect of oncolytic viruses.
Cytokine & growth factor reviews 2010;21(2-3):135-41.
2010: Marianne M Stanford; John C Bell; Markus J V Vähä-Koskela
Novel oncolytic viruses: riding high on the next wave?
Cytokine & growth factor reviews 2010;21(2-3):177-83.
2010: Tommy Alain; XueQing Lun; Yvan Martineau; Polen Sean; Bali Pulendran; Emmanuel Petroulakis; Franz J Zemp; Chantal G Lemay; Dominic Roy; John C Bell; George Thomas; Sara C Kozma; Peter A Forsyth; Mauro Costa-Mattioli; Nahum Sonenberg
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1576-81.
2010: Heather MacTavish; Jean-Simon Diallo; Baocheng Huang; Marianne Stanford; Fabrice Le Boeuf; Naomi De Silva; Julie Cox; John Graydon Simmons; Tanya Guimond; Theresa Falls; J Andrea McCart; Harry Atkins; Caroline Breitbach; David Kirn; Stephen Thorne; John C Bell
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.
PloS one 2010;5(12):e14462.
2010: Jari E Heikkilä; Markus J V Vähä-Koskela; Janne J Ruotsalainen; Miika W Martikainen; Marianne M Stanford; J Andrea McCart; John C Bell; Ari E Hinkkanen
Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice.
PloS one 2010;5(1):e8603.
2010: Kilian Guse; Marta Sloniecka; Iulia Diaconu; Kathryn Ottolino-Perry; Nan Tang; Calvin Ng; Fabrice Le Boeuf; John C Bell; J Andrea McCart; Ari Ristimäki; Sari Pesonen; Vincenzo Cerullo; Akseli Hemminki
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Journal of virology 2010;84(2):856-66.
2009: Xue Qing Lun; Ji-Hyun Jang; Nan Tang; Helen Deng; Renee Head; John C Bell; David F Stojdl; Catherine L Nutt; Donna L Senger; Peter A Forsyth; J Andrea McCart
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2777-88.
2009: Kelley A Parato; Brian Lichty; John C Bell
Diplomatic immunity: turning a foe into an ally.
Current opinion in molecular therapeutics 2009;11(1):13-21.
2009: Christopher Brown; Kyle B Stephenson; Stephen Hanson; Michael Kucharczyk; Roy Duncan; John C Bell; Brian Lichty
The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis.
Journal of virology 2009;83(2):552-61.
2008: Thi Lien-Anh Nguyên; Hesham Abdelbary; Meztli Arguello; Caroline Breitbach; Simon Leveille; Jean-Simon Diallo; Amber Yasmeen; Tarek A Bismar; David H Kirn; Theresa Falls; Valerie E Snoulten; Barbara C Vanderhyden; Joel Werier; Harold Atkins; Markus J V Vähä-Koskela; David F Stojdl; John C Bell; John Hiscott
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14981-6.
2008: Robert E Edge; Theresa J Falls; Christopher Brown; Brian Lichty; Harold Atkins; John C Bell
A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1437-43.
2008: Anthony T Power; John C Bell
Taming the Trojan horse: optimizing dynamic carrier cell/oncolytic virus systems for cancer biotherapy.
Gene therapy 2008;15(10):772-9.
2008: Rodney Colina; Mauro Costa-Mattioli; Ryan J O Dowling; Maritza Jaramillo; Lee-Hwa Tai; Caroline J Breitbach; Yvan Martineau; Ola Larsson; Liwei Rong; Yuri V Svitkin; Andrew P Makrigiannis; John C Bell; Nahum Sonenberg
Translational control of the innate immune response through IRF-7.
Nature 2008;452(7185):323-8.
2008: Yushui Wu; Xueqing Lun; Hongyuan Zhou; Limei Wang; Beichen Sun; John C Bell; John W Barrett; Grant McFadden; Jaclyn A Biegel; Donna L Senger; Peter A Forsyth
Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1218-27.
2008: Marianne M Stanford; Caroline J Breitbach; John C Bell; Grant McFadden
Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes?
Current opinion in molecular therapeutics 2008;10(1):32-7.
2007: Apollina Goel; Stephanie K Carlson; Kelly L Classic; Suzanne Greiner; Shruthi Naik; Anthony T Power; John C Bell; stephen russell
Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene.
Blood 2007;110(7):2342-50.
2007: Caroline J Breitbach; Jennifer M Paterson; Chantal G Lemay; Theresa J Falls; Allison McGuire; Kelley A Parato; David F Stojdl; Manijeh Daneshmand; Kelly Speth; David Kirn; J Andrea McCart; Harold Atkins; John C Bell
Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1686-93.
2007: Anthony T Power; John C Bell
Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):660-5.
2007: Anthony T Power; Jiahu Wang; Theresa J Falls; Jennifer M Paterson; Kelley A Parato; Brian Lichty; David F Stojdl; Peter A Forsyth; Harold Atkins; John C Bell
Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):123-30.
2006: Jaime Blais; John C Bell
Novel therapeutic target: the PERKs of inhibiting the integrated stress response.
Cell cycle (Georgetown, Tex.) 2006;5(24):2874-7.
2006: Jaime D Blais; Christina L Addison; Robert Edge; Theresa J Falls; Huijun Zhao; Kishore K Wary; Constantinos Koumenis; Heather P Harding; David Ron; Martin Holcik; John C Bell
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.
Molecular and cellular biology 2006;26(24):9517-32.
2006: Xueqing Lun; Donna L Senger; Tommy Alain; Andra Oprea; Kelley A Parato; David F Stojdl; Brian Lichty; Anthony T Power; Randal Johnston; Mark Hamilton; Ian F Parney; John C Bell; Peter A Forsyth
Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas.
Journal of the National Cancer Institute 2006;98(21):1546-57.
2006: Brian Lichty; Heidi McBride; Stephen Hanson; John C Bell
Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif.
The Journal of general virology 2006;87(Pt 11):3379-84.
2006: Nicoleta Hosszu Ungureanu; Mireille Cloutier; Stephen Lewis; Naomi de Silva; Jaime D Blais; John C Bell; Martin Holcik
Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.
The Journal of biological chemistry 2006;281(22):15155-63.
2006: Scott A Laurie; John C Bell; Harold Atkins; Joanne Roach; Michael K Bamat; James D O'Neil; M Scot Roberts; William S Groene; Robert M Lorence
A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2555-62.
2005: Kelley A Parato; Donna L Senger; Peter A Forsyth; John C Bell
Recent progress in the battle between oncolytic viruses and tumours.
Nature reviews. Cancer 2005;5(12):965-76.
2005: Eun-Hee Park; Joseph M Lee; Jaime D Blais; John C Bell; Jerry Pelletier
Internal translation initiation mediated by the angiogenic factor Tie2.
The Journal of biological chemistry 2005;280(22):20945-53.
2004: Dionissios Baltzis; Like Qu; Stavroula Papadopoulou; Jaime D Blais; John C Bell; Nahum Sonenberg; Antonis E Koromilas
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Journal of virology 2004;78(23):12747-61.
2004: Brian Lichty; David F Stojdl; Rebecca A Taylor; Leigh Miller; Irina Frenkel; Harold Atkins; John C Bell
Vesicular stomatitis virus: a potential therapeutic virus for the treatment of hematologic malignancy.
Human gene therapy 2004;15(9):821-31.
2004: Jaime D Blais; Vasilisa Filipenko; Meixia Bi; Heather P Harding; David Ron; Constantinos Koumenis; Bradly G Wouters; John C Bell
Activating transcription factor 4 is translationally regulated by hypoxic stress.
Molecular and cellular biology 2004;24(17):7469-82.
2004: Brian Lichty; Anthony T Power; David F Stojdl; John C Bell
Vesicular stomatitis virus: re-inventing the bullet.
Trends in molecular medicine 2004;10(5):210-6.
2003: David F Stojdl; Brian Lichty; Benjamin R Tenoever; Jennifer M Paterson; Anthony T Power; Shane Knowles; Ricardo Marius; Jennifer Reynard; Laurent Poliquin; Harold Atkins; Earl G Brown; Russell K Durbin; Joan E Durbin; John Hiscott; John C Bell
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.
Cancer cell 2003;4(4):263-75.
2003: Helen H Tai; Margit Geisterfer; John C Bell; Mariko Moniwa; James Davie; Lorrie Boucher; Michael W McBurney
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
Biochemical and biophysical research communications 2003;308(1):170-6.
2003: John C Bell; Brian Lichty; David F Stojdl
Getting oncolytic virus therapies off the ground.
Cancer cell 2003;4(1):7-11.
2003: Heather P Harding; Yuhong Zhang; Huiquing Zeng; Isabel Novoa; Phoebe D Lu; Marcella Calfon; Navid Sadri; Chi Yun; Brian Popko; Richard S Paules; David F Stojdl; John C Bell; Thore Hettmann; Jeffrey M Leiden; David Ron
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Molecular cell 2003;11(3):619-33.
2002: John C Bell; K A Garson; Brian Lichty; David F Stojdl
Oncolytic viruses: programmable tumour hunters.
Current gene therapy 2002;2(2):243-54.
2001: marc desforges; Jean-Benoit Frenette Charron; S Bérard; S Beausoleil; David F Stojdl; Geneviève Despars; B Laverdière; John C Bell; Pierre J Talbot; C P Stanners; Laurent Poliquin
Different host-cell shutoff strategies related to the matrix protein lead to persistence of vesicular stomatitis virus mutants on fibroblast cells.
Virus research 2001;76(1):87-102.
2000: David F Stojdl; Neena Abraham; Shane Knowles; Ricardo Marius; A Brasey; Brian Lichty; Earl G Brown; N Sonenberg; John C Bell
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.
Journal of virology 2000;74(20):9580-5.
2000: David F Stojdl; Brian Lichty; Shane Knowles; Ricardo Marius; Harold Atkins; N Sonenberg; John C Bell
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus.
Nature medicine 2000;6(7):821-5.
1999: Andrew R Cuddihy; Suiyang Li; NW Tam; Andrew Hoi-Tao Wong; Yoichi Taya; Neena Abraham; John C Bell; Antonis E Koromilas
Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.
Molecular and cellular biology 1999;19(4):2475-84.
1999: Neena Abraham; David F Stojdl; Peter Duncan; N Méthot; T Ishii; Manon Dubé; Barbara C Vanderhyden; Harold Atkins; Douglas A Gray; Michael W McBurney; Antonis E Koromilas; Earl G Brown; N Sonenberg; John C Bell
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.
The Journal of biological chemistry 1999;274(9):5953-62.
1999: David F Stojdl; John C Bell
SR protein kinases: the splice of life.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1999;77(4):293-8.
1998: Neena Abraham; M L Jaramillo; Peter Duncan; N Méthot; P L Icely; David F Stojdl; Glen N Barber; John C Bell
The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.
Experimental cell research 1998;244(2):394-404.
1998: Peter Duncan; David F Stojdl; Ricardo Marius; K H Scheit; John C Bell
The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.
Experimental cell research 1998;241(2):300-8.
1997: Peter Duncan; David F Stojdl; Ricardo Marius; John C Bell
In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.
Molecular and cellular biology 1997;17(10):5996-6001.
1996: Karen Colwill; Tony Pawson; Brenda Andrews; J Prasad; James L Manley; John C Bell; Peter Duncan
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Peter Duncan; B W Howell; Ricardo Marius; S Drmanic; E M Douville; John C Bell
Alternative splicing of STY, a nuclear dual specificity kinase.
The Journal of biological chemistry 1995;270(37):21524-31.
1995: M L Jaramillo; Neena Abraham; John C Bell
The interferon system: a review with emphasis on the role of PKR in growth control.
Cancer investigation 1995;13(3):327-38.
1994: M L Jaramillo; Daniel E H Afar; Guillermina Almazan; John C Bell
Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.
The Journal of biological chemistry 1994;269(44):27240-5.
1994: E Douville; Peter Duncan; N Abraham; John C Bell
Dual specificity kinases--a new family of signal transducers.
Cancer metastasis reviews 1994;13(1):1-7.
1993: Guillermina Almazan; Daniel E H Afar; John C Bell
Phosphorylation and disruption of intermediate filament proteins in oligodendrocyte precursor cultures treated with calyculin A.
Journal of neuroscience research 1993;36(2):163-72.
1992: E M Douville; Daniel E H Afar; B W Howell; K Letwin; L Tannock; Y Ben-David; Tony Pawson; John C Bell
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Molecular and cellular biology 1992;12(6):2681-9.
1992: Daniel E H Afar; C P Stanners; John C Bell
Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen.
Biochimica et biophysica acta 1992;1134(1):46-52.
1991: P L Icely; P Gros; J J Bergeron; A Devault; Daniel E H Afar; John C Bell
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine.
The Journal of biological chemistry 1991;266(24):16073-7.
1991: Daniel E H Afar; Ricardo Marius; J L Salzer; C P Stanners; Peter E Braun; John C Bell
Cell adhesion properties of myelin-associated glycoprotein in L cell fibroblasts.
Journal of neuroscience research 1991;29(4):429-36.
1991: B W Howell; Daniel E H Afar; J Lew; E M Douville; P L Icely; D A Gray; John C Bell
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Molecular and cellular biology 1991;11(1):568-72.
1990: Daniel E H Afar; J L Salzer; J Roder; Peter E Braun; John C Bell
Differential phosphorylation of myelin-associated glycoprotein isoforms in cell culture.
Journal of neurochemistry 1990;55(4):1418-26.
1989: E Horvath; A M Edwards; John C Bell; Peter E Braun
Chemical deglycosylation on a micro-scale of membrane glycoproteins with retention of phosphoryl-protein linkages.
Journal of neuroscience research 1989;24(3):398-401.
1989: W H Colledge; A Gebhardt; M D Edge; John C Bell
Analysis of A-MuLV transformed fibroblast lines for amplification of the c-myc, p53 and c-fos nuclear proto-oncogenes.
Oncogene 1989;4(6):753-7.
1989: A M Edwards; Peter E Braun; John C Bell
Phosphorylation of myelin-associated glycoprotein in vivo and in vitro occurs only in the cytoplasmic domain of the large isoform.
Journal of neurochemistry 1989;52(1):317-20.
1988: A M Edwards; M Arquint; Peter E Braun; J C Roder; Robert J Dunn; T Pawson; John C Bell
Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain.
Molecular and cellular biology 1988;8(6):2655-8.
1988: John C Bell
Oncogenes.
Cancer letters 1988;40(1):1-5.
1988: Michael W McBurney; K R Reuhl; A I Ally; S Nasipuri; John C Bell; J Craig
Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(3):1063-73.
1988: John C Bell; L Mahadevan; W H Colledge; M J Fry; A Raymond Frackelton; M G Sargent; J G Foulkes
Mechanisms of transformation by protein-tyrosine kinases.
Advances in experimental medicine and biology 1988;231():475-80.
1987: John C Bell; L C Mahadevan; W H Colledge; A Raymond Frackelton; M G Sargent; J G Foulkes
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA.
Nature 1987;325(6104):552-4.
1987: John C Bell; J Campione-Piccardo; J Craig; K R Reuhl; M W McBurney
Restricted replication of herpes simplex virus type 1 in murine embryonal carcinoma cells.
The Journal of general virology 1987;68 ( Pt 2)():555-68.
1986: A Gebhardt; John C Bell; J G Foulkes
Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice.
The EMBO journal 1986;5(9):2191-5.
1986: M W McBurney; J Campione-Piccardo; S C Smith; John C Bell
The mechanism of chemically-induced differentiation of a mouse embryonal carcinoma cell line.
Progress in clinical and biological research 1986;226():175-9.