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John Bell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Oncolytic Virotherapy

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Lun Xue Qing; Jang Ji-Hyun; Tang Nan; Deng Helen; Head Renee; Bell John C; Stojdl David F; Nutt Catherine L; Senger Donna L; Forsyth Peter A; McCart J Andrea
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide.
Parato Kelley A; Lichty Brian D; Bell John C
Diplomatic immunity: turning a foe into an ally.
Brown Christopher W; Stephenson Kyle B; Hanson Stephen; Kucharczyk Michael; Duncan Roy; Bell John C; Lichty Brian D
The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis.

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All Publications

2009: Lun Xue Qing; Jang Ji-Hyun; Tang Nan; Deng Helen; Head Renee; Bell John C; Stojdl David F; Nutt Catherine L; Senger Donna L; Forsyth Peter A; McCart J Andrea
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2777-88.
2009: Parato Kelley A; Lichty Brian D; Bell John C
Diplomatic immunity: turning a foe into an ally.
Current opinion in molecular therapeutics 2009;11(1):13-21.
2009: Brown Christopher W; Stephenson Kyle B; Hanson Stephen; Kucharczyk Michael; Duncan Roy; Bell John C; Lichty Brian D
The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis.
Journal of virology 2009;83(2):552-61.
2008: Nguyên Thi Lien-Anh; Abdelbary Hesham; Arguello Meztli; Breitbach Caroline; Leveille Simon; Diallo Jean-Simon; Yasmeen Amber; Bismar Tarek A; Kirn David; Falls Theresa; Snoulten Valerie E; Vanderhyden Barbara C; Werier Joel; Atkins Harold; Vähä-Koskela Markus J V; Stojdl David F; Bell John C; Hiscott John
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14981-6.
2008: Edge Robert E; Falls Theresa J; Brown Christopher W; Lichty Brian D; Atkins Harold; Bell John C
A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1437-43.
2008: Power A T; Bell J C
Taming the Trojan horse: optimizing dynamic carrier cell/oncolytic virus systems for cancer biotherapy.
Gene therapy 2008;15(10):772-9.
2008: Colina Rodney; Costa-Mattioli Mauro; Dowling Ryan J O; Jaramillo Maritza; Tai Lee-Hwa; Breitbach Caroline J; Martineau Yvan; Larsson Ola; Rong Liwei; Svitkin Yuri V; Makrigiannis Andrew P; Bell John C; Sonenberg Nahum
Translational control of the innate immune response through IRF-7.
Nature 2008;452(7185):323-8.
2008: Wu Yushui; Lun Xueqing; Zhou Hongyuan; Wang Limei; Sun Beichen; Bell John C; Barrett John W; McFadden Grant; Biegel Jaclyn A; Senger Donna L; Forsyth Peter A
Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1218-27.
2008: Stanford Marianne M; Breitbach Caroline J; Bell John C; McFadden Grant
Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes?
Current opinion in molecular therapeutics 2008;10(1):32-7.
2007: Goel Apollina; Carlson Stephanie K; Classic Kelly L; Greiner Suzanne; Naik Shruthi; Power Anthony T; Bell John C; Russell Stephen J
Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene.
Blood 2007;110(7):2342-50.
2007: Breitbach Caroline J; Paterson Jennifer M; Lemay Chantal G; Falls Theresa J; McGuire Allison; Parato Kelley A; Stojdl David F; Daneshmand Manijeh; Speth Kelly; Kirn David; McCart J Andrea; Atkins Harold; Bell John C
Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1686-93.
2007: Power Anthony T; Bell John C
Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):660-5.
2007: Power Anthony T; Wang Jiahu; Falls Theresa J; Paterson Jennifer M; Parato Kelley A; Lichty Brian D; Stojdl David F; Forsyth Peter A J; Atkins Harry; Bell John C
Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):123-30.
2006: Blais Jaime; Bell John C
Novel therapeutic target: the PERKs of inhibiting the integrated stress response.
Cell cycle (Georgetown, Tex.) 2006;5(24):2874-7.
2006: Blais Jaime D; Addison Christina L; Edge Robert; Falls Theresa; Zhao Huijun; Wary Kishore; Koumenis Costas; Harding Heather P; Ron David; Holcik Martin; Bell John C
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.
Molecular and cellular biology 2006;26(24):9517-32.
2006: Lun XueQing; Senger Donna L; Alain Tommy; Oprea Andra; Parato Kelley; Stojdl Dave; Lichty Brian; Power Anthony; Johnston Randal N; Hamilton Mark; Parney Ian; Bell John C; Forsyth Peter A
Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas.
Journal of the National Cancer Institute 2006;98(21):1546-57.
2006: Lichty Brian D; McBride Heidi; Hanson Stephen; Bell John C
Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif.
The Journal of general virology 2006;87(Pt 11):3379-84.
2006: Ungureanu Nicoleta Hosszu; Cloutier Mireille; Lewis Stephen M; de Silva Naomi; Blais Jaime D; Bell John C; Holcik Martin
Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.
The Journal of biological chemistry 2006;281(22):15155-63.
2006: Laurie Scott A; Bell John C; Atkins Harold L; Roach Joanne; Bamat Michael K; O'Neil James D; Roberts M Scot; Groene William S; Lorence Robert M
A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2555-62.
2005: Parato Kelley A; Senger Donna; Forsyth Peter A J; Bell John C
Recent progress in the battle between oncolytic viruses and tumours.
Nature reviews. Cancer 2005;5(12):965-76.
2005: Park Eun-Hee; Lee Joseph M; Blais Jaime D; Bell John C; Pelletier Jerry
Internal translation initiation mediated by the angiogenic factor Tie2.
The Journal of biological chemistry 2005;280(22):20945-53.
2004: Baltzis Dionissios; Qu Li-Ke; Papadopoulou Stavroula; Blais Jaime D; Bell John C; Sonenberg Nahum; Koromilas Antonis E
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Journal of virology 2004;78(23):12747-61.
2004: Lichty Brian D; Stojdl David F; Taylor Rebecca A; Miller Leigh; Frenkel Irina; Atkins Harold; Bell John C
Vesicular stomatitis virus: a potential therapeutic virus for the treatment of hematologic malignancy.
Human gene therapy 2004;15(9):821-31.
2004: Blais Jaime D; Filipenko Vasilisa; Bi Meixia; Harding Heather P; Ron David; Koumenis Costas; Wouters Bradly G; Bell John C
Activating transcription factor 4 is translationally regulated by hypoxic stress.
Molecular and cellular biology 2004;24(17):7469-82.
2004: Lichty Brian D; Power Anthony T; Stojdl David F; Bell John C
Vesicular stomatitis virus: re-inventing the bullet.
Trends in molecular medicine 2004;10(5):210-6.
2003: Stojdl David F; Lichty Brian D; tenOever Benjamin R; Paterson Jennifer M; Power Anthony T; Knowles Shane; Marius Ricardo; Reynard Jennifer; Poliquin Laurent; Atkins Harold; Brown Earl G; Durbin Russell K; Durbin Joan E; Hiscott John; Bell John C
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.
Cancer cell 2003;4(4):263-75.
2003: Tai Helen H; Geisterfer Margit; Bell John C; Moniwa Mariko; Davie James R; Boucher Lorrie; McBurney Michael W
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
Biochemical and biophysical research communications 2003;308(1):170-6.
2003: Bell John C; Lichty Brian; Stojdl David
Getting oncolytic virus therapies off the ground.
Cancer cell 2003;4(1):7-11.
2003: Harding Heather P; Zhang Yuhong; Zeng Huiquing; Novoa Isabel; Lu Phoebe D; Calfon Marcella; Sadri Navid; Yun Chi; Popko Brian; Paules Richard; Stojdl David F; Bell John C; Hettmann Thore; Leiden Jeffrey M; Ron David
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Molecular cell 2003;11(3):619-33.
2002: Bell J C; Garson K A; Lichty B D; Stojdl D F
Oncolytic viruses: programmable tumour hunters.
Current gene therapy 2002;2(2):243-54.
2001: Desforges M; Charron J; Bérard S; Beausoleil S; Stojdl D F; Despars G; Laverdière B; Bell J C; Talbot P J; Stanners C P; Poliquin L
Different host-cell shutoff strategies related to the matrix protein lead to persistence of vesicular stomatitis virus mutants on fibroblast cells.
Virus research 2001;76(1):87-102.
2000: Stojdl D F; Abraham N; Knowles S; Marius R; Brasey A; Lichty B D; Brown E G; Sonenberg N; Bell J C
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.
Journal of virology 2000;74(20):9580-5.
2000: Stojdl D F; Lichty B; Knowles S; Marius R; Atkins H; Sonenberg N; Bell J C
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus.
Nature medicine 2000;6(7):821-5.
1999: Cuddihy A R; Li S; Tam N W; Wong A H; Taya Y; Abraham N; Bell J C; Koromilas A E
Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.
Molecular and cellular biology 1999;19(4):2475-84.
1999: Abraham N; Stojdl D F; Duncan P I; Méthot N; Ishii T; Dubé M; Vanderhyden B C; Atkins H L; Gray D A; McBurney M W; Koromilas A E; Brown E G; Sonenberg N; Bell J C
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.
The Journal of biological chemistry 1999;274(9):5953-62.
1999: Stojdl D F; Bell J C
SR protein kinases: the splice of life.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1999;77(4):293-8.
1998: Abraham N; Jaramillo M L; Duncan P I; Méthot N; Icely P L; Stojdl D F; Barber G N; Bell J C
The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.
Experimental cell research 1998;244(2):394-404.
1998: Duncan P I; Stojdl D F; Marius R M; Scheit K H; Bell J C
The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.
Experimental cell research 1998;241(2):300-8.
1997: Duncan P I; Stojdl D F; Marius R M; Bell J C
In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.
Molecular and cellular biology 1997;17(10):5996-6001.
1996: Colwill K; Pawson T; Andrews B; Prasad J; Manley J L; Bell J C; Duncan P I
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Duncan P I; Howell B W; Marius R M; Drmanic S; Douville E M; Bell J C
Alternative splicing of STY, a nuclear dual specificity kinase.
The Journal of biological chemistry 1995;270(37):21524-31.
1995: Jaramillo M L; Abraham N; Bell J C
The interferon system: a review with emphasis on the role of PKR in growth control.
Cancer investigation 1995;13(3):327-38.
1994: Jaramillo M L; Afar D E; Almazan G; Bell J C
Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.
The Journal of biological chemistry 1994;269(44):27240-5.
1994: Douville E; Duncan P; Abraham N; Bell J C
Dual specificity kinases--a new family of signal transducers.
Cancer metastasis reviews 1994;13(1):1-7.
1993: Almazan G; Afar D E; Bell J C
Phosphorylation and disruption of intermediate filament proteins in oligodendrocyte precursor cultures treated with calyculin A.
Journal of neuroscience research 1993;36(2):163-72.
1992: Douville E M; Afar D E; Howell B W; Letwin K; Tannock L; Ben-David Y; Pawson T; Bell J C
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Molecular and cellular biology 1992;12(6):2681-9.
1992: Afar D E; Stanners C P; Bell J C
Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen.
Biochimica et biophysica acta 1992;1134(1):46-52.
1991: Afar D E; Marius R M; Salzer J L; Stanners C P; Braun P E; Bell J C
Cell adhesion properties of myelin-associated glycoprotein in L cell fibroblasts.
Journal of neuroscience research 1991;29(4):429-36.
1991: Icely P L; Gros P; Bergeron J J; Devault A; Afar D E; Bell J C
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine.
The Journal of biological chemistry 1991;266(24):16073-7.
1991: Howell B W; Afar D E; Lew J; Douville E M; Icely P L; Gray D A; Bell J C
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Molecular and cellular biology 1991;11(1):568-72.
1990: Afar D E; Salzer J L; Roder J; Braun P E; Bell J C
Differential phosphorylation of myelin-associated glycoprotein isoforms in cell culture.
Journal of neurochemistry 1990;55(4):1418-26.
1989: Horvath E; Edwards A M; Bell J C; Braun P E
Chemical deglycosylation on a micro-scale of membrane glycoproteins with retention of phosphoryl-protein linkages.
Journal of neuroscience research 1989;24(3):398-401.
1989: Colledge W H; Gebhardt A; Edge M D; Bell J C
Analysis of A-MuLV transformed fibroblast lines for amplification of the c-myc, p53 and c-fos nuclear proto-oncogenes.
Oncogene 1989;4(6):753-7.
1989: Edwards A M; Braun P E; Bell J C
Phosphorylation of myelin-associated glycoprotein in vivo and in vitro occurs only in the cytoplasmic domain of the large isoform.
Journal of neurochemistry 1989;52(1):317-20.
1988: Edwards A M; Arquint M; Braun P E; Roder J C; Dunn R J; Pawson T; Bell J C
Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain.
Molecular and cellular biology 1988;8(6):2655-8.
1988: Bell J C
Oncogenes.
Cancer letters 1988;40(1):1-5.
1988: McBurney M W; Reuhl K R; Ally A I; Nasipuri S; Bell J C; Craig J
Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(3):1063-73.
1988: Bell J C; Mahadevan L; Colledge W H; Fry M J; Frackelton A R; Sargent M G; Foulkes J G
Mechanisms of transformation by protein-tyrosine kinases.
Advances in experimental medicine and biology 1988;231():475-80.
1987: Bell J C; Campione-Piccardo J; Craig J; Reuhl K R; McBurney M W
Restricted replication of herpes simplex virus type 1 in murine embryonal carcinoma cells.
The Journal of general virology 1987;68 ( Pt 2)():555-68.
1987: Bell J C; Mahadevan L C; Colledge W H; Frackelton A R; Sargent M G; Foulkes J G
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA.
Nature 1987;325(6104):552-4.
1986: Gebhardt A; Bell J C; Foulkes J G
Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice.
The EMBO journal 1986;5(9):2191-5.
1986: McBurney M W; Campione-Piccardo J; Smith S C; Bell J C
The mechanism of chemically-induced differentiation of a mouse embryonal carcinoma cell line.
Progress in clinical and biological research 1986;226():175-9.

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John Bell

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