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Masaki Nakane

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Publications

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J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger
Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.
Ryan M Fryer; Jason A Segreti; Deborah L Widomski; Pamela H Franklin; Patricia N Banfor; Kristin A Koch; Masaki Nakane; J Ruth Wu-Wong; Bryan Cox; Glenn A Reinhart
Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet.
J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger
VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells.

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All Publications

2007: J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger
Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.
American journal of physiology. Renal physiology 2007;293(5):F1592-604.
2007: Ryan M Fryer; Jason A Segreti; Deborah L Widomski; Pamela H Franklin; Patricia N Banfor; Kristin A Koch; Masaki Nakane; J Ruth Wu-Wong; Bryan Cox; Glenn A Reinhart
Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet.
The Journal of pharmacology and experimental therapeutics 2007;323(1):217-26.
2007: J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger
VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells.
Journal of cellular biochemistry 2007;100(6):1395-405.
2007: Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger; Ruth Wu-Wong
Mechanistic analysis of VDR-mediated renin suppression.
Nephron. Physiology 2007;107(2):p35-44.
2007: Ryan M Fryer; Pamela A Rakestraw; Masaki Nakane; Doug Dixon; Patricia N Banfor; Kristin A Koch; J Ruth Wu-Wong; Glenn A Reinhart
Differential inhibition of renin mRNA expression by paricalcitol and calcitriol in C57/BL6 mice.
Nephron. Physiology 2007;106(4):p76-81.
2007: J Ruth Wu-Wong; Masaki Nakane; Junli Ma
Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells.
Journal of vascular research 2007;44(1):11-8.
2007: Masaki Nakane; Junli Ma; Andrew E Rose; Mark A Osinski; J Ruth Wu-Wong
Differential effects of Vitamin D analogs on calcium transport.
The Journal of steroid biochemistry and molecular biology 2007;103(1):84-9.
2006: Meena V Patel; Teodozyi Kolasa; Kathleen H Mortell; Mark A Matulenko; Ahmed A Hakeem; Jeffrey J Rohde; Sherry L Nelson; Marlon D Cowart; Masaki Nakane; Loan N Miller; Marie E Uchic; Marc A Terranova; Odile F El-Kouhen; Diana L Donnelly-Roberts; Marian T Namovic; Peter R Hollingsworth; Renjie Chang; Brenda Martino; Jill M Wetter; Kennan Marsh; Ruth Martin; John F Darbyshire; Gary Gintant; Gin C Hsieh; Robert B Moreland; James P Sullivan; Jorge D Brioni; Andrew O Stewart
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Journal of medicinal chemistry 2006;49(25):7450-65.
2006: Masaki Nakane; Teodozyi Kolasa; Renjie Chang; Loan N Miller; Robert B Moreland; Jorge D Brioni
Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator.
Journal of pharmacological sciences 2006;102(2):231-8.
2006: Teodozyi Kolasa; Mark A Matulenko; Ahmed A Hakeem; Meena V Patel; Kathleen H Mortell; Pramila Bhatia; Rodger Henry; Masaki Nakane; Gin C Hsieh; Marc A Terranova; Marie E Uchic; Loan N Miller; Renjie Chang; Diana L Donnelly-Roberts; Marian T Namovic; Peter R Hollingsworth; Brenda Martino; Odile F El-Kouhen; Kennan Marsh; Jill M Wetter; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Journal of medicinal chemistry 2006;49(17):5093-109.
2006: J Ruth Wu-Wong; William Noonan; Junli Ma; Doug Dixon; Masaki Nakane; Antoinette L Bolin; Kristin A Koch; Steve P Postl; Sherry J Morgan; Glenn A Reinhart
Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification.
The Journal of pharmacology and experimental therapeutics 2006;318(1):90-8.
2006: J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Xiaoan Ruan; Paul Kroeger
Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells.
Atherosclerosis 2006;186(1):20-8.
2006: J Ruth Wu-Wong; Masaki Nakane; Junli Ma; Doug Dixon; Gerard Gagne
Vitamin D receptor (VDR) localization in human promyelocytic leukemia cells.
Leukemia & lymphoma 2006;47(4):727-32.
2006: J Ruth Wu-Wong; Jin Tian; Masaki Nakane; Junli Ma; Thomas A Fey; Paul Kroeger; Ryan M Fryer; Glenn A Reinhart
Cardiovascular disease in chronic kidney failure: the role of VDR activators.
Current opinion in investigational drugs (London, England : 2000) 2006;7(3):206-13.
2006: J Ruth Wu-Wong; Masaki Nakane; Junli Ma
Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells.
Thrombosis research 2006;118(6):709-14.
2006: Masaki Nakane; Thomas A Fey; Douglas B Dixon; Junli Ma; Michael E Brune; Yan Chun Li; J Ruth Wu-Wong
Differential effects of Vitamin D analogs on bone formation and resorption.
The Journal of steroid biochemistry and molecular biology 2006;98(1):72-7.
2006: Mark G Anderson; Masaki Nakane; Xiaoan Ruan; Paul Kroeger; J Ruth Wu-Wong
Expression of VDR and CYP24A1 mRNA in human tumors.
Cancer chemotherapy and pharmacology 2006;57(2):234-40.
2005: Guo Zhu Zheng; Pramila Bhatia; Jerome F Daanen; Teodozyi Kolasa; Meena Patel; Steven P Latshaw; Odile F El-Kouhen; Renjie Chang; Marie E Uchic; Loan Miller; Masaki Nakane; Sonya G Lehto; Marie P Honore; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
Journal of medicinal chemistry 2005;48(23):7374-88.
2005: Xueqing Wang; Pramila Bhatia; Jerome F Daanen; Steve P Latsaw; Jeffrey J Rohde; Teodozyi Kolasa; Ahmed A Hakeem; Mark A Matulenko; Masaki Nakane; Marie E Uchic; Loan N Miller; Renjie Chang; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.
Bioorganic & medicinal chemistry 2005;13(15):4667-78.
2005: Masaki Nakane; Marlon D Cowart; Gin C Hsieh; Loan Miller; Marie E Uchic; Renjie Chang; Marc A Terranova; Diana L Donnelly-Roberts; Marian T Namovic; Thomas R Miller; Jill M Wetter; Kennan Marsh; Andrew O Stewart; Jorge D Brioni; Robert B Moreland
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Neuropharmacology 2005;49(1):112-21.
2005: Mark A Osinski; Marie E Uchic; Terese R Seifert; Thomas K Shaughnessy; Loan N Miller; Masaki Nakane; Bryan Cox; Jorge D Brioni; Robert B Moreland
Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets.
Pharmacology, biochemistry, and behavior 2005;81(1):211-9.
2005: J Ruth Wu-Wong; Masaki Nakane; Linda Traylor; Xiaoan Ruan; Paul Kroeger; Jin Tian
Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs?
Current opinion in investigational drugs (London, England : 2000) 2005;6(3):245-54.
2004: Mark A Matulenko; Bruce W Surber; Leimin Fan; Teodozyi Kolasa; Masaki Nakane; Marc A Terranova; Marie E Uchic; Loan N Miller; Renjie Chang; Diana L Donnelly-Roberts; Marian T Namovic; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.
Bioorganic & medicinal chemistry letters 2004;14(20):5095-8.
2004: Robert B Moreland; Masaki Nakane; Diana L Donnelly-Roberts; Loan N Miller; Renjie Chang; Marie E Uchic; Marc A Terranova; Earl J Gubbins; Rosalind J Helfrich; Marian T Namovic; Odile F El-Kouhen; Jeffrey N Masters; Jorge D Brioni
Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5).
Biochemical pharmacology 2004;68(4):761-72.
2004: Marlon D Cowart; Steven P Latshaw; Pramila Bhatia; Jerome F Daanen; Jeffrey J Rohde; Sherry L Nelson; Meena Patel; Teodozyi Kolasa; Masaki Nakane; Marie E Uchic; Loan N Miller; Marc A Terranova; Renjie Chang; Diana L Donnelly-Roberts; Marian T Namovic; Peter R Hollingsworth; Brenda Martino; James J Lynch; James P Sullivan; Gin C Hsieh; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
Journal of medicinal chemistry 2004;47(15):3853-64.
2004: Mark A Matulenko; Ahmed A Hakeem; Teodozyi Kolasa; Masaki Nakane; Marc A Terranova; Marie E Uchic; Loan N Miller; Renjie Chang; Diana L Donnelly-Roberts; Marian T Namovic; Robert B Moreland; Jorge D Brioni; Andrew O Stewart
Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists.
Bioorganic & medicinal chemistry 2004;12(13):3471-83.
2004: Jorge D Brioni; Robert B Moreland; Marlon D Cowart; Gin C Hsieh; Andrew O Stewart; Petter Hedlund; Diana L Donnelly-Roberts; Masaki Nakane; James J Lynch; Teodozyi Kolasa; James S Polakowski; Mark A Osinski; Kennan Marsh; Karl-Erik Andersson; James P Sullivan
Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6758-63.
2004: Andrew O Stewart; Marlon D Cowart; Robert B Moreland; Steven P Latshaw; Mark A Matulenko; Pramila Bhatia; Xueqing Wang; Jerome F Daanen; Sherry L Nelson; Marc A Terranova; Marian T Namovic; Diana L Donnelly-Roberts; Loan N Miller; Masaki Nakane; James P Sullivan; Jorge D Brioni
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
Journal of medicinal chemistry 2004;47(9):2348-55.
2004: Steven W Elmore; John K Pratt; Michael J Coghlan; Yue Mao; Brian E Green; David D Anderson; Michael Stashko; Chun W Lin; Doug H Falls; Masaki Nakane; Loan Miller; Curtis Tyree; Jeffrey N Miner; Ben Lane
Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.
Bioorganic & medicinal chemistry letters 2004;14(7):1721-7.
2003: Masaki Nakane
Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(7):865-70.
2003: Michael J Coghlan; Peer B Jacobson; Ben Lane; Masaki Nakane; Chun W Lin; Steven W Elmore; Philip R Kym; Jay R Luly; George W Carter; Russell Turner; Curtis Tyree; Junlian Hu; Marc Elgort; Jon Rosen; Jeffrey N Miner
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):860-9.
2003: Philip R Kym; Michael E Kort; Michael J Coghlan; Jimmie L Moore; Rui Tang; James D Ratajczyk; Daniel P Larson; Steven W Elmore; John K Pratt; Michael Stashko; H Douglas Falls; Chun W Lin; Masaki Nakane; Loan Miller; Curtis Tyree; Jeffrey N Miner; Peer B Jacobson; Denise M Wilcox; Phong Nguyen; Benjamin C Lane
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Journal of medicinal chemistry 2003;46(6):1016-30.
2003: Loan N Miller; Masaki Nakane; Gin C Hsieh; Renjie Chang; Teodozyi Kolasa; Robert B Moreland; Jorge D Brioni
A-350619: a novel activator of soluble guanylyl cyclase.
Life sciences 2003;72(9):1015-25.
2003: Jeffrey N Miner; Curtis Tyree; Junlian Hu; Elaine Berger; Keith B Marschke; Masaki Nakane; Michael J Coghlan; Dave Clemm; Ben Lane; Jon Rosen
A nonsteroidal glucocorticoid receptor antagonist.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):117-27.
2002: Yung- Wu Chen; Morey L Smith; Grace X Chiou; Stephen J Ballaron; Michael P Sheets; Earl J Gubbins; Usha Warrior; Julie Wilkins; Carol S Surowy; Masaki Nakane; George W Carter; James M Trevillyan; Karl W Mollison; Stevan W Djuric
TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators.
Cellular immunology 2002;220(2):134-42.
2002: Robert J Altenbach; Albert Khilevich; Michael D Meyer; Steven A Buckner; Ivan Milicic; Anthony V Daza; Michael E Brune; Alyssa B O'Neill; Donna M Gauvin; John C Cain; Masaki Nakane; Mark W Holladay; Michael Williams; Jorge D Brioni; James P Sullivan
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
Journal of medicinal chemistry 2002;45(20):4395-7.
2002: Chun W Lin; Masaki Nakane; Michael Stashko; Doug H Falls; Jane Kuk; Loan Miller; Ruth Huang; Curtis Tyree; Jeffrey N Miner; Jon Rosen; Philip R Kym; Michael J Coghlan; George Carter; Benjamin C Lane
trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers.
Molecular pharmacology 2002;62(2):297-303.
2002: Masaki Nakane; Gin C Hsieh; Loan N Miller; Renjie Chang; Marc A Terranova; Robert B Moreland; Teodozyi Kolasa; Jorge D Brioni
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.
International journal of impotence research 2002;14(2):121-7.
2002: Jorge D Brioni; Masaki Nakane; Gin C Hsieh; Robert B Moreland; Teodozyi Kolasa; James P Sullivan
Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction.
International journal of impotence research 2002;14(1):8-14.
2001: Steven A Buckner; Ivan Milicic; Anthony V Daza; James J Lynch; Teodozyi Kolasa; Masaki Nakane; James P Sullivan; Jorge D Brioni
A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity.
European journal of pharmacology 2001;433(1):123-7.
2001: Michael J Coghlan; Philip R Kym; Steven W Elmore; AX Wang; Jay R Luly; Denise Wilcox; Michael Stashko; Chun W Lin; J Miner; Curtis Tyree; Masaki Nakane; Peer Jacobson; Benjamin C Lane
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Journal of medicinal chemistry 2001;44(18):2879-85.
2001: Robert B Moreland; Gin C Hsieh; Masaki Nakane; Jorge D Brioni
The biochemical and neurologic basis for the treatment of male erectile dysfunction.
The Journal of pharmacology and experimental therapeutics 2001;296(2):225-34.