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Takeo Nakanishi

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TOP 3
Yang Lu; Takeo Nakanishi; Ikumi Tamai
Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate.
Yoshiyuki Shirasaka; Takanori Mori; Yukiko Murata; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.
Yoshiyuki Shirasaka; Kazuyuki Hayashi; Taku Kasai; Takeo Nakanishi; Akio Nishiura; Yasuhiro Ohno; Megumi Shichiri; Ikumi Tamai
A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS.

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All Publications

2013: Yang Lu; Takeo Nakanishi; Ikumi Tamai
Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate.
Drug metabolism and pharmacokinetics 2013;28(2):153-8.
2013: Yoshiyuki Shirasaka; Takanori Mori; Yukiko Murata; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):615-21.
2013: Yoshiyuki Shirasaka; Kazuyuki Hayashi; Taku Kasai; Takeo Nakanishi; Akio Nishiura; Yasuhiro Ohno; Megumi Shichiri; Ikumi Tamai
A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS.
The Journal of endocrinology 2013;217(3):265-74.
2013: Yoshiyuki Shirasaka; Takanori Mori; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
Journal of pharmaceutical sciences 2013;102(1):280-8.
2012: Hiroshi Arakawa; Keiichi Kawai; Atsushi Mizokami; Takeo Nakanishi; Mikio Namiki; Tomohiro Nishimoto; Tomohiko Wakayama; Chihiro Yanagihara; Ikumi Tamai
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.
Biochemical pharmacology 2012;84(8):1070-7.
2012: Hiroshi Arakawa; Makoto Haga; Takeo Nakanishi; Yoshiyuki Shirasaka; Ikumi Tamai
Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.
Biopharmaceutics & drug disposition 2012;33(6):332-41.
2012: Takeo Nakanishi; Douglas Ross
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.
Chinese journal of cancer 2012;31(2):73-99.
2012: Atsushi Hosomi; Takeo Nakanishi; Takuya Fujita; Ikumi Tamai
Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2.
PloS one 2012;7(2):e30456.
2012: Yoshiyuki Shirasaka; Takanori Mori; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.
Drug metabolism and pharmacokinetics 2012;27(3):360-4.
2012: Takeo Nakanishi; Ikumi Tamai
Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs.
Drug metabolism and pharmacokinetics 2012;27(1):106-21.
2011: Takeo Nakanishi; Kazuyo Ohe; Masanobu Sato; Yoshiyuki Shirasaka; Akimasa Fukushi; Tomoka Gose; Keiichi Kawai; Masato Kobayashi; Mayuko Yoshifuji; Ikumi Tamai
Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.
Molecular pharmaceutics 2011;8(6):2142-50.
2011: Takeo Nakanishi; Ikumi Tamai
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy.
Journal of pharmaceutical sciences 2011;100(9):3731-50.
2011: Yoshiyuki Shirasaka; Kensuke Suzuki; Takeo Nakanishi; Ikumi Tamai
Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.
Journal of pharmaceutical sciences 2011;100(9):3843-53.
2011: Takeo Nakanishi; Yuta Shibue; Yoko Fukuyama; Kenji Yoshida; Hajime Fukuda; Yoshiyuki Shirasaka; Ikumi Tamai
Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):984-91.
2011: Masanobu Sato; Tomohiko Wakayama; Hideaki Mamada; Yoshiyuki Shirasaka; Takeo Nakanishi; Ikumi Tamai
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Biochimica et biophysica acta 2011;1808(6):1441-7.
2011: Masaya Mizutani; Fuyuhiko Inagaki; Takeo Nakanishi; Chihiro Yanagihara; Ikumi Tamai; Chisato Mukai
Total syntheses of (-)- and (+)-goniomitine.
Organic letters 2011;13(7):1796-9.
2011: Yoshiyuki Shirasaka; Kensuke Suzuki; Megumi Shichiri; Takeo Nakanishi; Ikumi Tamai
Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.
Drug metabolism and pharmacokinetics 2011;26(2):171-9.
2011: Takeo Nakanishi; Tsunemitsu Haruta; Yoshiyuki Shirasaka; Ikumi Tamai
Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):117-22.
2010: Leslie M Tompkins; Haishan Li; Linhao Li; Caitlin Lynch; Yi Xie; Takeo Nakanishi; Douglas Ross; Hongbing Wang
A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.
Biochemical pharmacology 2010;80(11):1754-61.
2010: Yoshiyuki Shirasaka; Kensuke Suzuki; Takeo Nakanishi; Ikumi Tamai
Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.
Pharmaceutical research 2010;27(10):2141-9.
2010: Tomoji Maeda; Masanori Irokawa; Hiroshi Arakawa; Erika Kuraoka; Takashi Nozawa; Ryoko Tateoka; Yoshiharu Itoh; Takeo Nakanishi; Ikumi Tamai
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer.
The Journal of steroid biochemistry and molecular biology 2010;122(4):180-5.
2010: Xuetao Fan; Douglas Ross; Hiroshi Arakawa; Vadivel Ganapathy; Ikumi Tamai; Takeo Nakanishi
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors.
Biochemical pharmacology 2010;80(6):811-8.
2010: Toshimichi Nakamura; Takeo Nakanishi; Tsunemitsu Haruta; Yoshiyuki Shirasaka; John P Keogh; Ikumi Tamai
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.
Molecular pharmaceutics 2010;7(1):187-95.
2010: Takeo Nakanishi; Douglas Ross; Keisuke Mitsuoka
Methods to evaluate transporter activity in cancer.
Methods in molecular biology (Clifton, N.J.) 2010;637():105-20.
2010: Masanobu Sato; Hideaki Mamada; Naohiko Anzai; Yoshiyuki Shirasaka; Takeo Nakanishi; Ikumi Tamai
Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.
Biological & pharmaceutical bulletin 2010;33(3):498-503.
2010: Douglas Ross; Takeo Nakanishi
Impact of breast cancer resistance protein on cancer treatment outcomes.
Methods in molecular biology (Clifton, N.J.) 2010;596():251-90.
2010: Yoshiyuki Shirasaka; Erika Kuraoka; Hildegard Spahn-Langguth; Takeo Nakanishi; Peter Langguth; Ikumi Tamai
Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.
The Journal of pharmacology and experimental therapeutics 2010;332(1):181-9.
2009: Keisuke Mitsuoka; Yoshiyuki Shirasaka; Akimasa Fukushi; Masanobu Sato; Toshimichi Nakamura; Takeo Nakanishi; Ikumi Tamai
Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells.
Biopharmaceutics & drug disposition 2009;30(3):126-37.
2008: Yingqiu Xie; Kexin Xu; Douglas E Linn; Xi Yang; Zhiyong Guo; Hermela Shimelis; Takeo Nakanishi; Douglas Ross; Hegang Chen; Ladan Fazli; Martin E Gleave; Yun Qiu
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
The Journal of biological chemistry 2008;283(6):3349-56.
2007: Takeo Nakanishi
Drug transporters as targets for cancer chemotherapy.
Cancer genomics & proteomics 2007;4(3):241-54.
2006: Rachael Strong; Takeo Nakanishi; Douglas Ross; Catherine Fenselau
Alterations in the mitochondrial proteome of adriamycin resistant MCF-7 breast cancer cells.
Journal of proteome research 2006;5(9):2389-95.
2006: John P O'Neill; Chidambaram Natesa Velalar; Dong I Lee; Bin Zhang; Takeo Nakanishi; Yao Tang; Florin Selaru; Douglas Ross; Meltzer Stephen J.; Arif Hussain
Thapsigargin resistance in human prostate cancer cells.
Cancer 2006;107(3):649-59.
2006: Takeo Nakanishi; Ken Shiozawa; Bret A Hassel; Douglas Ross
Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression.
Blood 2006;108(2):678-84.
2006: Takeo Nakanishi; Kimberly J Bailey-Dell; Bret A Hassel; Ken Shiozawa; Daniel M Sullivan; Joel Turner; Douglas Ross
Novel 5' untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: implications for drug resistance, tissue-specific expression, and alternative promoter usage.
Cancer research 2006;66(10):5007-11.
2005: Yuexing Zhang; Xin-Wei Wang; Danijela Jelovac; Takeo Nakanishi; Myoung-Hee Yu; Damilola Akinmade; Olga Goloubeva; Douglas Ross; Angela Brodie; Anne W Hamburger
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9890-5.
2005: Tushar S Garimella; Douglas Ross; Julie L Eiseman; J T Mondick; Erin Joseph; Takeo Nakanishi; S E Bates; Kenneth S. Bauer
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors.
Cancer chemotherapy and pharmacology 2005;55(2):101-9.
2004: Attaya Suvannasankha; Hans Minderman; Kieran L O'Loughlin; Takeo Nakanishi; Laurie A Ford; William R Greco; Meir Wetzler; Douglas Ross; Maria R Baer
Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival.
British journal of haematology 2004;127(4):392-8.
2004: Attaya Suvannasankha; Hans Minderman; Kieran L O'Loughlin; Takeo Nakanishi; William R Greco; Douglas Ross; Maria R Baer
Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function.
Leukemia 2004;18(7):1252-7.
2004: Partha Krishnamurthy; Douglas Ross; Takeo Nakanishi; Kimberly J Bailey-Dell; Sheng Zhou; Kelly E Mercer; Balázs Sarkadi; Brian P Sorrentino; John D Schuetz
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
The Journal of biological chemistry 2004;279(23):24218-25.
2004: Ikumi Tamai; Takeo Nakanishi; Daisuke Kobayashi; Kayoko China; Yohei Kosugi; Jun-ichi Nezu; Yoshimichi Sai; Akira Tsuji
Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.
Molecular pharmaceutics 2004;1(1):57-66.
2003: Takeo Nakanishi; L Austin Doyle; Bret A Hassel; Yuetong Wei; Kenneth S. Bauer; Suhlan Wu; David W Pumplin; Hongbin Fang; Douglas Ross
Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis.
Molecular pharmacology 2003;64(6):1452-62.
2003: Takeo Nakanishi; Judith E Karp; Ming Tan; L Austin Doyle; Todd Peters; Weidong Yang; David Wei; Douglas Ross
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3320-8.
2003: Judith E Karp; Douglas Ross; Weidong Yang; Michael L Tidwell; Yuetong Wei; Jacqueline Greer; Dean L Mann; Takeo Nakanishi; John J Wright; A Dimitrios Colevas
Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):307-15.
2002: Yasuto Kido; Ikumi Tamai; Takeo Nakanishi; Toru Kagami; Iori Hirosawa; Yoshimichi Sai; Akira Tsuji
Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.
Drug metabolism and pharmacokinetics 2002;17(1):34-41.
2001: Takeo Nakanishi; Takahiro Hatanaka; Wei Huang; Puttur D Prasad; Fred H Leibach; Malliga E Ganapathy; Vadivel Ganapathy
Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes.
The Journal of physiology 2001;532(Pt 2):297-304.
2001: Takahiro Hatanaka; Takeo Nakanishi; Wei Huang; Fred H Leibach; Puttur D Prasad; Vadivel Ganapathy; Malliga E Ganapathy
Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+).
The Journal of clinical investigation 2001;107(8):1035-43.
2000: Takeo Nakanishi; Ikumi Tamai; A Takaki; Akira Tsuji
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity.
International journal of cancer. Journal international du cancer 2000;88(2):274-80.
1999: Ryoichi Kizu; Takeo Nakanishi; K Hayakawa; A Matsuzawa; Masazumi Eriguchi; Yasutaka Takeda; Nachio Akiyama; T Tashiro; Yoko Kidani
A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: trans-(n-valerato)chloro(1R,2R-cyclohexanediamine) (oxalato)platinum(IV).
Cancer chemotherapy and pharmacology 1999;43(2):97-105.
1998: Ikumi Tamai; Takeo Nakanishi; H Nakahara; Yoshimichi Sai; Vadivel Ganapathy; F H Leibach; Akira Tsuji
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.
Journal of pharmaceutical sciences 1998;87(12):1542-6.
1998: Ryoichi Kizu; Takeo Nakanishi; S Yamamoto; K Hayakawa; A Matsuzawa; Masazumi Eriguchi; Yasutaka Takeda; Nachio Akiyama; Yoko Kidani
Significance of water solubility in the gastrointestinal absorption of trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)platinum(IV), an orally active antitumor platinum complex, and its analogs.
Anti-cancer drugs 1998;9(2):167-74.
1997: Takeo Nakanishi; I Tamai; Y Sai; Takuma Sasaki; A Tsuji
Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.
Cancer research 1997;57(18):4118-22.
1997: Ikumi Tamai; Takeo Nakanishi; K Hayashi; T Terao; Yoshimichi Sai; T Shiraga; Ken-ichi Miyamoto; E Takeda; H Higashida; Akira Tsuji
The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.
The Journal of pharmacy and pharmacology 1997;49(8):796-801.
1996: Yoshimichi Sai; Ikumi Tamai; H Sumikawa; K Hayashi; Takeo Nakanishi; Osamu Amano; M Numata; Shoichi Iseki; A Tsuji
Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics.
FEBS letters 1996;392(1):25-9.
1996: Ryoichi Kizu; Takeo Nakanishi; M Miyazaki; T Tashiro; M Noji; A Matsuzawa; Masazumi Eriguchi; Yasutaka Takeda; Nachio Akiyama; Yoko Kidani
An orally active antitumor cyclohexanediamine-Pt(IV) complex: trans,cis,cis-bis(n-valerato)(oxalato)(1R,2R-cyclohexane diamine)Pt(IV).
Anti-cancer drugs 1996;7(3):248-56.