Andriy Luzhetskyy

Research Profile

Living Beings

Chemicals & Drugs

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Physiology

Procedures

Disorders

Mutagenesis, Insertional

Phenomena

Glycosylation

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Publications

TOP 3
Simone Herrmann; Theresa Siegl; Marta Luzhetska; Lutz Petzke; Caroline Jilg; Elisabeth Welle; Annette Erb; Peter F Leadlay; Andreas Bechthold; Andriy Luzhetskyy
Site-specific recombination strategies for engineering actinomycete genomes.
Liliya Horbal; Yuriy Rebets; Mariya Rabyk; Roman Makitrynskyy; Andriy Luzhetskyy; Victor Fedorenko; Andreas Bechthold
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.
Maksym Myronovskyi; Elisabeth Welle; Viktor Fedorenko; Andriy Luzhetskyy
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes.

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All Publications

2012: Simone Herrmann; Theresa Siegl; Marta Luzhetska; Lutz Petzke; Caroline Jilg; Elisabeth Welle; Annette Erb; Peter F Leadlay; Andreas Bechthold; Andriy Luzhetskyy
Site-specific recombination strategies for engineering actinomycete genomes.
Applied and environmental microbiology 2012;78(6):1804-12.
2012: Liliya Horbal; Yuriy Rebets; Mariya Rabyk; Roman Makitrynskyy; Andriy Luzhetskyy; Victor Fedorenko; Andreas Bechthold
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.
AMB Express 2012;2(1):1.
2011: Maksym Myronovskyi; Elisabeth Welle; Viktor Fedorenko; Andriy Luzhetskyy
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes.
Applied and environmental microbiology 2011;77(15):5370-83.
2011: Johannes Härle; Stefan Günther; Benjamin Lauinger; Monika Weber; Bernd Kammerer; David L Zechel; Andriy Luzhetskyy; Andreas Bechthold
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase.
Chemistry & biology 2011;18(4):520-30.
2010: Theresa Siegl; Lutz Petzke; Elisabeth Welle; Andriy Luzhetskyy
I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomyces.
Applied microbiology and biotechnology 2010;87(4):1525-32.
2010: Liliya Horbal; Yuriy Rebets; Maria Rabyk; Andriy Luzhetskyy; Bogdan Ostash; Elisabeth Welle; Tatsunosuke Nakamura; Victor Fedorenko; Andreas Bechthold
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117.
Applied microbiology and biotechnology 2010;85(4):1069-79.
2009: Lutz Petzke; Andriy Luzhetskyy
In vivo Tn5-based transposon mutagenesis of Streptomycetes.
Applied microbiology and biotechnology 2009;83(5):979-86.
2009: Annette Erb; Christine Krauth; Andriy Luzhetskyy; Andreas Bechthold
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis.
Applied microbiology and biotechnology 2009;83(6):1067-76.
2009: Annette Erb; Andriy Luzhetskyy; Uwe Hardter; Andreas Bechthold
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains.
Chembiochem : a European journal of chemical biology 2009;10(8):1392-401.
2009: Christine Krauth; Marta Fedoryshyn; Christian Schleberger; Andriy Luzhetskyy; Andreas Bechthold
Engineering a function into a glycosyltransferase.
Chemistry & biology 2009;16(1):28-35.
2008: Andriy Luzhetskyy; Andreas Bechthold
Features and applications of bacterial glycosyltransferases: current state and prospects.
Applied microbiology and biotechnology 2008;80(6):945-52.
2008: Andriy Luzhetskyy; Jens Hoffmann; Stefan Pelzer; Sven-Eric Wohlert; Andreas Vente; Andreas Bechthold
Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity.
Applied microbiology and biotechnology 2008;80(1):15-9.
2008: Marta Fedoryshyn; Lutz Petzke; Elisabeth Welle; Andreas Bechthold; Andriy Luzhetskyy
Marker removal from actinomycetes genome using Flp recombinase.
Gene 2008;419(1-2):43-7.
2008: Iryna Ostash; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Suzanne Walker; Victor Fedorenko
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136.
FEMS microbiology letters 2008;285(2):195-202.
2008: Marta Fedoryshyn; Elisabeth Welle; Andreas Bechthold; Andriy Luzhetskyy
Functional expression of the Cre recombinase in actinomycetes.
Applied microbiology and biotechnology 2008;78(6):1065-70.
2008: Yuriy Rebets; Lilia Dutko; Bohdan Ostash; Andriy Luzhetskyy; Olexandr Kulachkovskyy; Toshio Yamaguchi; Tatsunosuke Nakamura; Andreas Bechthold; Victor Fedorenko
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes.
Archives of microbiology 2008;189(2):111-20.
2008: Carmen Méndez; Andriy Luzhetskyy; Andreas Bechthold; José A Salas
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern.
Current topics in medicinal chemistry 2008;8(8):710-24.
2008: Andriy Luzhetskyy; Carmen Méndez; Jose A Salas; Andreas Bechthold
Glycosyltransferases, important tools for drug design.
Current topics in medicinal chemistry 2008;8(8):680-709.
2007: Andriy Luzhetskyy; Stefan Pelzer; Andreas Bechthold
The future of natural products as a source of new antibiotics.
Current opinion in investigational drugs (London, England : 2000) 2007;8(8):608-13.
2007: Andriy Luzhetskyy; Holger Weiss; Annette Charge; Elisabeth Welle; Anton Linnenbrink; Andreas Vente; Andreas Bechthold
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.
Applied microbiology and biotechnology 2007;75(6):1367-75.
2007: M Fedoryshyn; M Nur-e-Alam; L Zhu; A Luzhetskyy; J Rohr; A Bechthold
Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.
Journal of biotechnology 2007;130(1):32-8.
2007: Andriy Luzhetskyy; Almuth Mayer; Jens Hoffmann; Stefan Pelzer; Meike Holzenkämper; Bettina Schmitt; Sven-Eric Wohlert; Andreas Vente; Andreas Bechthold
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase.
Chembiochem : a European journal of chemical biology 2007;8(6):599-602.
2007: Christian Hertweck; Andriy Luzhetskyy; Yuri Rebets; Andreas Bechthold
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
Natural product reports 2007;24(1):162-90.
2007: Lili Zhu; Andriy Luzhetskyy; Martha Luzhetska; Cynthia Mattingly; Val Adams; Andreas Bechthold; Jürgen Rohr
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.
Chembiochem : a European journal of chemical biology 2007;8(1):83-8.
2006: Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).
Angewandte Chemie (International ed. in English) 2006;45(46):7842-6.
2006: Giorgos Sianidis; Sven-Eric Wohlert; Charalambos Pozidis; Spyridoula Karamanou; Andriy Luzhetskyy; Andreas Vente; Anastassios Economou
Cloning, purification and characterization of a functional anthracycline glycosyltransferase.
Journal of biotechnology 2006;125(3):425-33.
2006: A Luzhetskyy; M Fedoryshyn; O Gromyko; B Ostash; Y Rebets; A Bechthold; V Fedorenko
IncP plasmids are most effective in mediating conjugation between Escherichia coli and streptomycetes.
Genetika 2006;42(5):595-601.
2006: Clemens Dürr; Hans-Jörg Schnell; Andriy Luzhetskyy; Renato Murillo; Monika Weber; Katrin Welzel; Andreas Vente; Andreas Bechthold
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives.
Chemistry & biology 2006;13(4):365-77.
2006: Lilia Dutko; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Tatsunosuke Nakamura; Victor Fedorenko
A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912.
FEMS microbiology letters 2006;255(2):280-5.
2005: Almuth Mayer; Takaaki Taguchi; Anton Linnenbrink; Carsten Hofmann; Andriy Luzhetskyy; Andreas Bechthold
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology 2005;6(12):2312-5.
2005: Andriy Luzhetskyy; Andreas Bechthold
It works: combinatorial biosynthesis for generating novel glycosylated compounds.
Molecular microbiology 2005;58(1):3-5.
2005: Andriy Luzhetskyy; Takaaki Taguchi; Marta Fedoryshyn; Clemens Dürr; Sven-Eric Wohlert; Volodymyr Novikov; Andreas Bechthold
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology 2005;6(8):1406-10.
2005: Andriy Luzhetskyy; Andreas Vente; Andreas Bechthold
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides.
Molecular bioSystems 2005;1(2):117-26.
2005: Andriy Luzhetskyy; Marta Fedoryshyn; Clemens Dürr; Takaaki Taguchi; Volodymyr Novikov; Andreas Bechthold
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.
Chemistry & biology 2005;12(7):725-9.
2005: Andriy Luzhetskyy; Lili Zhu; Miranda Gibson; Marta Fedoryshyn; Clemens Dürr; Carsten Hofmann; Dirk Hoffmeister; Bohdan Ostash; Cynthia Mattingly; Val Adams; et al.
Generation of novel landomycins M and O through targeted gene disruption.
Chembiochem : a European journal of chemical biology 2005;6(4):675-8.
2005: Lili Zhu; Bohdan Ostash; Uwe Rix; Mohammad Nur-E-Alam; Almuth Mayers; Andriy Luzhetskyy; Carmen Mendez; Jose A Salas; Andreas Bechthold; Victor Fedorenko; et al.
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
The Journal of organic chemistry 2005;70(2):631-8.
2005: A Bechthold; G Weitnauer; A Luzhetskyy; M Berner; C Bihlmeier; R Boll; C Dürr; A Frerich; C Hofmann; A Mayer; et al.
Glycosyltransferases and other tailoring enzymes as tools for the generation of novel compounds.
Ernst Schering Research Foundation workshop 2005;(51):147-63.
2005: Yu Rebets; B Ostash; A Luzhetskyy; S Kushnir; M Fukuhara; A Bechthold; M Nashimoto; T Nakamura; V Fedorenko
DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912.
Microbiology (Reading, England) 2005;151(Pt 1):281-90.
2004: Andriy Luzhetskyy; Tao Liu; Marta Fedoryshyn; Bohdan Ostash; Viktor Fedorenko; Jürgen Rohr; Andreas Bechthold
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology 2004;5(11):1567-70.
2004: Oleksandr Gromyko; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Masahiro Fukuhara; Andreas Bechthold; Tatsunosuke Nakamura; Victor Fedorenko
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization.
The Journal of antibiotics 2004;57(6):383-9.
2004: Bohdan Ostash; Uwe Rix; Lily L Remsing Rix; Tao Liu; Felipe Lombo; Andriy Luzhetskyy; Oleksandr Gromyko; Chenchen Wang; Alfredo F Braña; Carmen Méndez; et al.
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.
Chemistry & biology 2004;11(4):547-55.
2004: Ursula von Mulert; Andriy Luzhetskyy; Carsten Hofmann; Almuth Mayer; Andreas Bechthold
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene.
FEMS microbiology letters 2004;230(1):91-7.
2003: Y Rebets; B Ostash; A Luzhetskyy; D Hoffmeister; A Brana; C Mendez; J A Salas; A Bechthold; V Fedorenko
Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.
FEMS microbiology letters 2003;222(1):149-53.
2003: B Ostash; Y Rebets; V Yuskevich; A Luzhetskyy; V Tkachenko; V Fedorenko
Targeted disruption of Streptomyces globisporus lndF and lndL cyclase genes involved in landomycin E biosynthesis.
Folia microbiologica 2003;48(4):484-8.